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Aliases for AK5 Gene

Aliases for AK5 Gene

  • Adenylate Kinase 5 2 3
  • ATP-AMP Transphosphorylase 5 3 4
  • AK 5 3 4
  • Adenylate Kinase Isoenzyme 5 3
  • Adenylate Kinase 6 3
  • EC 2.7.4.3 4
  • EC 2.7.4.6 4
  • AK6 3

External Ids for AK5 Gene

Summaries for AK5 Gene

Entrez Gene Summary for AK5 Gene

  • This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for AK5 Gene

AK5 (Adenylate Kinase 5) is a Protein Coding gene. Diseases associated with AK5 include limbic encephalitis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include cAMP-dependent protein kinase regulator activity and adenylate kinase activity. An important paralog of this gene is CMPK1.

UniProtKB/Swiss-Prot for AK5 Gene

  • Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AK5 Gene

Genomics for AK5 Gene

Genomic Location for AK5 Gene

Start:
77,281,977 bp from pter
End:
77,559,969 bp from pter
Size:
277,993 bases
Orientation:
Plus strand

Genomic View for AK5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AK5 Gene

Regulatory Elements for AK5 Gene

Proteins for AK5 Gene

  • Protein details for AK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6K8-KAD5_HUMAN
    Recommended name:
    Adenylate kinase isoenzyme 5
    Protein Accession:
    Q9Y6K8
    Secondary Accessions:
    • Q5U622
    • Q6FH66
    • Q7Z4T5
    • Q86YS0
    • Q8N464
    • Q96EC9

    Protein attributes for AK5 Gene

    Size:
    562 amino acids
    Molecular mass:
    63333 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for AK5 Gene

    Alternative splice isoforms for AK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AK5 Gene

Proteomics data for AK5 Gene at MOPED

Post-translational modifications for AK5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AK5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for AK5 Gene

Domains for AK5 Gene

Gene Families for AK5 Gene

HGNC:
  • AK :Adenylate kinases

Protein Domains for AK5 Gene

UniProtKB/Swiss-Prot:

KAD5_HUMAN
Family:
  • Belongs to the adenylate kinase family.:
    • Q9Y6K8
genes like me logo Genes that share domains with AK5: view

Function for AK5 Gene

Molecular function for AK5 Gene

GENATLAS Biochemistry: adenylate kinase 5,located in the cytosol,expressed exclusively in brain
UniProtKB/Swiss-Prot CatalyticActivity: ATP + AMP = 2 ADP
UniProtKB/Swiss-Prot CatalyticActivity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
UniProtKB/Swiss-Prot Function: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.

Enzyme Numbers (IUBMB) for AK5 Gene

Gene Ontology (GO) - Molecular Function for AK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004017 adenylate kinase activity IEA --
GO:0004550 nucleoside diphosphate kinase activity IDA 23416111
GO:0005524 ATP binding IEA --
GO:0019205 nucleobase-containing compound kinase activity --
GO:0019206 nucleoside kinase activity EXP --
genes like me logo Genes that share ontologies with AK5: view

Phenotypes for AK5 Gene

genes like me logo Genes that share phenotypes with AK5: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AK5 Gene

Localization for AK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AK5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AK5 Gene COMPARTMENTS Subcellular localization image for AK5 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with AK5: view

Pathways for AK5 Gene

genes like me logo Genes that share pathways with AK5: view

Interacting Proteins for AK5 Gene

Gene Ontology (GO) - Biological Process for AK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process --
GO:0006165 nucleoside diphosphate phosphorylation IDA 23416111
GO:0006172 ADP biosynthetic process TAS 10215863
GO:0006173 dADP biosynthetic process TAS 10215863
GO:0009142 nucleoside triphosphate biosynthetic process IDA 23416111
genes like me logo Genes that share ontologies with AK5: view

Compounds for AK5 Gene

(6) HMDB Compounds for AK5 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
dADP
  • 2'-deoxyadenosine-5'-diphosphate
2793-06-8
Deoxyadenosine monophosphate
  • 2'-Deoxy-5'-adenylate
653-63-4

(1) Novoseek inferred chemical compound relationships for AK5 Gene

Compound -log(P) Hits PubMed IDs
adenylate 62.8 8
genes like me logo Genes that share compounds with AK5: view

Transcripts for AK5 Gene

Unigene Clusters for AK5 Gene

Adenylate kinase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AK5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for AK5 Gene

GeneLoc Exon Structure for
AK5
ECgene alternative splicing isoforms for
AK5

Expression for AK5 Gene

mRNA expression in normal human tissues for AK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AK5 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (8.3), Brain - Anterior cingulate cortex (BA24) (7.5), Brain - Hippocampus (5.9), Brain - Amygdala (5.4), Brain - Cortex (5.4), and Brain - Nucleus accumbens (basal ganglia) (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AK5 Gene

SOURCE GeneReport for Unigene cluster for AK5 Gene Hs.559718

mRNA Expression by UniProt/SwissProt for AK5 Gene

Q9Y6K8-KAD5_HUMAN
Tissue specificity: Brain specific
genes like me logo Genes that share expressions with AK5: view

Orthologs for AK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AK5 36
  • 99.76 (n)
  • 99.47 (a)
AK5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AK5 36
  • 92.65 (n)
  • 94.31 (a)
AK5 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AK5 36
  • 93.29 (n)
  • 95.9 (a)
AK5 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ak5 36
  • 86.36 (n)
  • 91.46 (a)
Ak5 16
Ak5 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AK5 37
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AK5 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC365985 36
  • 85.59 (n)
  • 91.28 (a)
chicken
(Gallus gallus)
Aves AK5 36
  • 75.94 (n)
  • 77.36 (a)
AK5 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AK5 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ak5 36
  • 71.14 (n)
  • 72.33 (a)
zebrafish
(Danio rerio)
Actinopterygii ak5 37
  • 64 (a)
OneToOne
LOC100003595 36
  • 65.77 (n)
  • 64.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta Adk1 37
  • 41 (a)
OneToMany
Adk1 38
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea F13E6.2 36
  • 45.12 (n)
  • 28.87 (a)
F38B2.4 37
  • 48 (a)
OneToMany
F38B2.4 38
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes URA6 37
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4395 37
  • 38 (a)
OneToMany
Species with no ortholog for AK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AK5 Gene

ENSEMBL:
Gene Tree for AK5 (if available)
TreeFam:
Gene Tree for AK5 (if available)

Paralogs for AK5 Gene

Paralogs for AK5 Gene

Selected SIMAP similar genes for AK5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AK5: view

Variants for AK5 Gene

Sequence variations from dbSNP and Humsavar for AK5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3509 -- 77,559,866(-) GCACA(A/G)CCATT utr-variant-3-prime
rs6485 -- 77,558,664(-) CAGAA(-/AAT/T)AATAG reference, frameshift-variant, cds-indel
rs721514 -- 77,330,234(-) TTAAA(A/C)TAGAG intron-variant
rs936001 -- 77,340,826(+) TAGTC(C/G)TCAAG intron-variant
rs936004 -- 77,316,897(-) TACAC(A/C)AAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AK5 Gene

Variant ID Type Subtype PubMed ID
esv272326 CNV Insertion 20981092
esv270640 CNV Insertion 20981092
nsv517088 CNV Loss 19592680
nsv818234 CNV Loss 17921354
nsv470719 CNV Gain 18288195
esv2676174 CNV Deletion 23128226
esv22538 CNV Loss 19812545
nsv441697 CNV CNV 18776908
essv9537 CNV CNV 17122850
dgv63e1 CNV Complex 17122850
nsv1522 CNV Insertion 18451855
esv2657556 CNV Deletion 23128226
nsv823254 CNV Loss 20364138
esv9520 OTHER Inversion 19470904
nsv871605 CNV Loss 21882294
nsv521371 CNV Loss 19592680
nsv462095 CNV Loss 19166990
esv2670780 CNV Deletion 23128226
esv1440178 CNV Deletion 17803354
esv2659731 CNV Deletion 23128226
esv2750152 CNV Deletion 23290073
esv1179842 CNV Deletion 17803354
nsv871143 CNV Gain 21882294
esv2656843 CNV Deletion 23128226
nsv1533 CNV Loss 18451855
nsv870709 CNV Loss 21882294
esv268641 CNV Insertion 20981092

Relevant External Links for AK5 Gene

HapMap Linkage Disequilibrium report
AK5

Disorders for AK5 Gene

(1) MalaCards Diseases for AK5 Gene

Search for AK5 Gene in MalaCards »

(1) University of Copenhagen DISEASES for AK5 Gene

Relevant External Links for AK5

Genetic Association Database (GAD)
AK5
Human Genome Epidemiology (HuGE) Navigator
AK5
genes like me logo Genes that share disorders with AK5: view

No data available for UniProtKB/Swiss-Prot for AK5 Gene

Publications for AK5 Gene

  1. Identification of two active functional domains of human adenylate kinase 5. (PMID: 19647735) Solaroli N. … Karlsson A. (FEBS Lett. 2009) 3 4 23
  2. Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein. (PMID: 10215863) Van Rompay A.R. … Karlsson A. (Eur. J. Biochem. 1999) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. (PMID: 23416111) Amiri M. … Solaroli N. (Int. J. Biochem. Cell Biol. 2013) 3 4

Products for AK5 Gene

Sources for AK5 Gene

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