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Aliases for AK5 Gene

Aliases for AK5 Gene

  • Adenylate Kinase 5 2 3 5
  • ATP-AMP Transphosphorylase 5 3 4
  • AK 5 3 4
  • Adenylate Kinase 6 3
  • EC 2.7.4.3 4
  • EC 2.7.4.6 4
  • AK6 3

External Ids for AK5 Gene

Previous GeneCards Identifiers for AK5 Gene

  • GC01P078086
  • GC01P076692
  • GC01P077152
  • GC01P077170
  • GC01P077459
  • GC01P077747
  • GC01P075878

Summaries for AK5 Gene

Entrez Gene Summary for AK5 Gene

  • This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for AK5 Gene

AK5 (Adenylate Kinase 5) is a Protein Coding gene. Diseases associated with AK5 include Limbic Encephalitis and Connective Tissue Cancer. Among its related pathways are Purine metabolism and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include nucleoside diphosphate kinase activity and nucleoside kinase activity. An important paralog of this gene is CMPK1.

UniProtKB/Swiss-Prot for AK5 Gene

  • Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AK5 Gene

Genomics for AK5 Gene

Regulatory Elements for AK5 Gene

Enhancers for AK5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AK5 on UCSC Golden Path with GeneCards custom track

Promoters for AK5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AK5 on UCSC Golden Path with GeneCards custom track

Genomic Location for AK5 Gene

Chromosome:
1
Start:
77,281,977 bp from pter
End:
77,559,969 bp from pter
Size:
277,993 bases
Orientation:
Plus strand

Genomic View for AK5 Gene

Genes around AK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AK5 Gene

Proteins for AK5 Gene

  • Protein details for AK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6K8-KAD5_HUMAN
    Recommended name:
    Adenylate kinase isoenzyme 5
    Protein Accession:
    Q9Y6K8
    Secondary Accessions:
    • Q5U622
    • Q6FH66
    • Q7Z4T5
    • Q86YS0
    • Q8N464
    • Q96EC9

    Protein attributes for AK5 Gene

    Size:
    562 amino acids
    Molecular mass:
    63333 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for AK5 Gene

    Alternative splice isoforms for AK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AK5 Gene

Proteomics data for AK5 Gene at MOPED

Post-translational modifications for AK5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AK5 Gene

No data available for DME Specific Peptides for AK5 Gene

Domains & Families for AK5 Gene

Gene Families for AK5 Gene

Protein Domains for AK5 Gene

Suggested Antigen Peptide Sequences for AK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6K8

UniProtKB/Swiss-Prot:

KAD5_HUMAN :
  • Belongs to the adenylate kinase family.
Family:
  • Belongs to the adenylate kinase family.
genes like me logo Genes that share domains with AK5: view

Function for AK5 Gene

Molecular function for AK5 Gene

GENATLAS Biochemistry:
adenylate kinase 5,located in the cytosol,expressed exclusively in brain
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + AMP = 2 ADP.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function:
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.

Enzyme Numbers (IUBMB) for AK5 Gene

Gene Ontology (GO) - Molecular Function for AK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with AK5: view
genes like me logo Genes that share phenotypes with AK5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AK5

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AK5 Gene

Localization for AK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AK5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AK5 Gene COMPARTMENTS Subcellular localization image for AK5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
mitochondrion 2
golgi apparatus 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for AK5 Gene

Pathways & Interactions for AK5 Gene

genes like me logo Genes that share pathways with AK5: view

Interacting Proteins for AK5 Gene

Gene Ontology (GO) - Biological Process for AK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process IEA --
GO:0006165 nucleoside diphosphate phosphorylation IDA 23416111
GO:0009220 pyrimidine ribonucleotide biosynthetic process TAS 10215863
GO:0016310 phosphorylation IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with AK5: view

No data available for SIGNOR curated interactions for AK5 Gene

Drugs & Compounds for AK5 Gene

(3) Drugs for AK5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Guanosine triphosphate Experimental Pharma 0

(4) Additional Compounds for AK5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
2793-06-8
Deoxyadenosine monophosphate
  • 2'-dAMP
  • 2'-Deoxy-5'-adenylate
  • 2'-Deoxy-5'-adenylic acid
  • 2'-Deoxy-Adenosine 5'-phosphorate
  • 2'-Deoxy-Adenosine 5'-phosphoric acid
653-63-4
genes like me logo Genes that share compounds with AK5: view

Transcripts for AK5 Gene

Unigene Clusters for AK5 Gene

Adenylate kinase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AK5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for AK5 Gene

GeneLoc Exon Structure for
AK5
ECgene alternative splicing isoforms for
AK5

Expression for AK5 Gene

mRNA expression in normal human tissues for AK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AK5 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.3), Brain - Anterior cingulate cortex (BA24) (x7.5), Brain - Hippocampus (x5.9), Brain - Amygdala (x5.4), Brain - Cortex (x5.4), and Brain - Nucleus accumbens (basal ganglia) (x5.3).

Protein differential expression in normal tissues from HIPED for AK5 Gene

This gene is overexpressed in Brain (42.8) and Frontal cortex (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AK5 Gene



SOURCE GeneReport for Unigene cluster for AK5 Gene Hs.559718

mRNA Expression by UniProt/SwissProt for AK5 Gene

Q9Y6K8-KAD5_HUMAN
Tissue specificity: Brain specific.
genes like me logo Genes that share expression patterns with AK5: view

Protein tissue co-expression partners for AK5 Gene

- Elite partner

Orthologs for AK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AK5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AK5 35
  • 92.65 (n)
  • 94.31 (a)
AK5 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AK5 35
  • 93.29 (n)
  • 95.9 (a)
AK5 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ak5 35
  • 86.36 (n)
  • 91.46 (a)
Ak5 16
Ak5 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AK5 35
  • 99.76 (n)
  • 99.47 (a)
AK5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC365985 35
  • 85.59 (n)
  • 91.28 (a)
oppossum
(Monodelphis domestica)
Mammalia AK5 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AK5 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves AK5 35
  • 75.94 (n)
  • 77.36 (a)
AK5 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AK5 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ak5 35
  • 71.14 (n)
  • 72.33 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100003595 35
  • 65.77 (n)
  • 64.64 (a)
ak5 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Adk1 37
  • 46 (a)
Adk1 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F38B2.4 37
  • 49 (a)
F13E6.2 35
  • 45.12 (n)
  • 28.87 (a)
F38B2.4 36
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes URA6 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4395 36
  • 38 (a)
OneToMany
Species with no ortholog for AK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AK5 Gene

ENSEMBL:
Gene Tree for AK5 (if available)
TreeFam:
Gene Tree for AK5 (if available)

Paralogs for AK5 Gene

Paralogs for AK5 Gene

(4) SIMAP similar genes for AK5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AK5: view

Variants for AK5 Gene

Sequence variations from dbSNP and Humsavar for AK5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2803140 - 77,521,909(-) CCTCC(C/T)GAGGA reference, missense
rs3509 -- 77,559,866(-) GCACA(A/G)CCATT utr-variant-3-prime
rs6485 -- 77,558,664(-) CAGAA(-/AAT/T)AATAG reference, frameshift-variant, cds-indel
rs721514 -- 77,330,234(-) TTAAA(A/C)TAGAG intron-variant
rs1010061 -- 77,346,523(+) ATAGG(A/G)TCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AK5 Gene

Variant ID Type Subtype PubMed ID
esv272326 CNV Insertion 20981092
esv270640 CNV Insertion 20981092
nsv517088 CNV Loss 19592680
nsv818234 CNV Loss 17921354
nsv470719 CNV Gain 18288195
esv2676174 CNV Deletion 23128226
esv22538 CNV Loss 19812545
nsv441697 CNV CNV 18776908
essv9537 CNV CNV 17122850
dgv63e1 CNV Complex 17122850
nsv1522 CNV Insertion 18451855
esv2657556 CNV Deletion 23128226
nsv823254 CNV Loss 20364138
esv9520 OTHER Inversion 19470904
nsv871605 CNV Loss 21882294
nsv521371 CNV Loss 19592680
nsv462095 CNV Loss 19166990
esv2670780 CNV Deletion 23128226
esv1440178 CNV Deletion 17803354
esv2659731 CNV Deletion 23128226
esv2750152 CNV Deletion 23290073
esv1179842 CNV Deletion 17803354
nsv871143 CNV Gain 21882294
esv2656843 CNV Deletion 23128226
nsv1533 CNV Loss 18451855
nsv870709 CNV Loss 21882294
esv268641 CNV Insertion 20981092

Variation tolerance for AK5 Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AK5 Gene

Human Gene Mutation Database (HGMD)
AK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AK5 Gene

Disorders for AK5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for AK5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
limbic encephalitis
connective tissue cancer
  • connective tissue neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search AK5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AK5

Genetic Association Database (GAD)
AK5
Human Genome Epidemiology (HuGE) Navigator
AK5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AK5
genes like me logo Genes that share disorders with AK5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AK5 Gene

Publications for AK5 Gene

  1. Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein. (PMID: 10215863) Van Rompay A.R. … Karlsson A. (Eur. J. Biochem. 1999) 2 3 4 67
  2. Identification of two active functional domains of human adenylate kinase 5. (PMID: 19647735) Solaroli N. … Karlsson A. (FEBS Lett. 2009) 3 23
  3. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. (PMID: 23416111) Amiri M. … Solaroli N. (Int. J. Biochem. Cell Biol. 2013) 3
  4. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. (PMID: 23898208) Johnson T.P. … Nath A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for AK5 Gene

Sources for AK5 Gene

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