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Aliases for AK5 Gene

Aliases for AK5 Gene

  • Adenylate Kinase 5 2 3 5
  • ATP-AMP Transphosphorylase 5 3 4
  • AK 5 3 4
  • Adenylate Kinase Isoenzyme 5 3
  • Adenylate Kinase 6 3
  • EC 2.7.4.3 4
  • EC 2.7.4.6 4
  • AK6 3

External Ids for AK5 Gene

Previous GeneCards Identifiers for AK5 Gene

  • GC01P078086
  • GC01P076692
  • GC01P077152
  • GC01P077170
  • GC01P077459
  • GC01P077747
  • GC01P075878

Summaries for AK5 Gene

Entrez Gene Summary for AK5 Gene

  • This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for AK5 Gene

AK5 (Adenylate Kinase 5) is a Protein Coding gene. Diseases associated with AK5 include Anterograde Amnesia and Prosopagnosia. Among its related pathways are Metabolism and purine nucleotides de novo biosynthesis. GO annotations related to this gene include nucleoside diphosphate kinase activity and nucleoside kinase activity. An important paralog of this gene is AK1.

UniProtKB/Swiss-Prot for AK5 Gene

  • Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AK5 Gene

Genomics for AK5 Gene

Regulatory Elements for AK5 Gene

Enhancers for AK5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F077509 1.7 FANTOM5 Ensembl ENCODE 16.5 +230.9 230942 7.1 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 AK5 ENSG00000233099 RNU7-8P RPL17P6 ZZZ3 GIPC2 FUBP1 GC01P077502 GC01P077577
GH01F077321 1.3 FANTOM5 Ensembl ENCODE 20 +40.1 40133 2.0 BACH1 ZNF316 ZNF766 NFE2 FOSL2 FOS MAFK NFE2L2 BHLHE40 MAFG AK5 ENSG00000233099 RNU7-8P FUBP1 LOC100131495
GH01F077429 0.7 Ensembl ENCODE 31.4 +149.6 149647 4.4 GATA3 CEBPB AK5 ENSG00000233099 GIPC2 GC01P077421 GC01P077502
GH01F077533 1.4 Ensembl ENCODE 13.4 +255.7 255690 8.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 AK5 ZZZ3 RPL17P6 FUBP1 GC01P077502 GC01P077577
GH01F077369 0.8 Ensembl ENCODE 17.4 +89.0 89026 2.4 JUND BHLHE40 SIN3A FOS MAFK AK5 ENSG00000233099 RNU7-8P GC01P077416
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AK5 on UCSC Golden Path with GeneCards custom track

Promoters for AK5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000539256 523 2201 CTCF SUZ12 ZIC2 HIC1 ZFHX2 GLIS2 ZBTB48 POLR2A PATZ1 SCRT2

Genomic Location for AK5 Gene

Chromosome:
1
Start:
77,281,977 bp from pter
End:
77,559,969 bp from pter
Size:
277,993 bases
Orientation:
Plus strand

Genomic View for AK5 Gene

Genes around AK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AK5 Gene

Proteins for AK5 Gene

  • Protein details for AK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6K8-KAD5_HUMAN
    Recommended name:
    Adenylate kinase isoenzyme 5
    Protein Accession:
    Q9Y6K8
    Secondary Accessions:
    • Q5U622
    • Q6FH66
    • Q7Z4T5
    • Q86YS0
    • Q8N464
    • Q96EC9

    Protein attributes for AK5 Gene

    Size:
    562 amino acids
    Molecular mass:
    63333 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for AK5 Gene

    Alternative splice isoforms for AK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AK5 Gene

Post-translational modifications for AK5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AK5 Gene

Domains & Families for AK5 Gene

Gene Families for AK5 Gene

Suggested Antigen Peptide Sequences for AK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6K8

UniProtKB/Swiss-Prot:

KAD5_HUMAN :
  • Belongs to the adenylate kinase family.
Family:
  • Belongs to the adenylate kinase family.
genes like me logo Genes that share domains with AK5: view

Function for AK5 Gene

Molecular function for AK5 Gene

GENATLAS Biochemistry:
adenylate kinase 5,located in the cytosol,expressed exclusively in brain
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + AMP = 2 ADP.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function:
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.

Enzyme Numbers (IUBMB) for AK5 Gene

Gene Ontology (GO) - Molecular Function for AK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004017 adenylate kinase activity IEA,TAS --
GO:0004550 nucleoside diphosphate kinase activity IEA,IDA 23416111
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with AK5: view
genes like me logo Genes that share phenotypes with AK5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AK5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AK5 Gene

Localization for AK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AK5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AK5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
mitochondrion 2
plasma membrane 1
peroxisome 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for AK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with AK5: view

Pathways & Interactions for AK5 Gene

genes like me logo Genes that share pathways with AK5: view

Gene Ontology (GO) - Biological Process for AK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process IEA --
GO:0006165 nucleoside diphosphate phosphorylation IDA 23416111
GO:0006172 ADP biosynthetic process TAS 10215863
GO:0006173 dADP biosynthetic process TAS 10215863
GO:0009142 nucleoside triphosphate biosynthetic process IDA 23416111
genes like me logo Genes that share ontologies with AK5: view

No data available for SIGNOR curated interactions for AK5 Gene

Drugs & Compounds for AK5 Gene

(3) Drugs for AK5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Guanosine triphosphate Experimental Pharma 0

(4) Additional Compounds for AK5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
2793-06-8
Deoxyadenosine monophosphate
  • 2'-dAMP
  • 2'-Deoxy-5'-adenylate
  • 2'-Deoxy-5'-adenylic acid
  • 2'-Deoxy-Adenosine 5'-phosphorate
  • 2'-Deoxy-Adenosine 5'-phosphoric acid
653-63-4
genes like me logo Genes that share compounds with AK5: view

Transcripts for AK5 Gene

Unigene Clusters for AK5 Gene

Adenylate kinase 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AK5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for AK5 Gene

GeneLoc Exon Structure for
AK5
ECgene alternative splicing isoforms for
AK5

Expression for AK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AK5 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.3), Brain - Anterior cingulate cortex (BA24) (x7.5), Brain - Hippocampus (x5.9), Brain - Amygdala (x5.4), Brain - Cortex (x5.4), and Brain - Nucleus accumbens (basal ganglia) (x5.3).

Protein differential expression in normal tissues from HIPED for AK5 Gene

This gene is overexpressed in Brain (42.8) and Frontal cortex (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AK5 Gene



Protein tissue co-expression partners for AK5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AK5 Gene:

AK5

SOURCE GeneReport for Unigene cluster for AK5 Gene:

Hs.559718

mRNA Expression by UniProt/SwissProt for AK5 Gene:

Q9Y6K8-KAD5_HUMAN
Tissue specificity: Brain specific.
genes like me logo Genes that share expression patterns with AK5: view

Orthologs for AK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AK5 34 35
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia AK5 34 35
  • 93.29 (n)
cow
(Bos Taurus)
Mammalia AK5 34 35
  • 92.65 (n)
mouse
(Mus musculus)
Mammalia Ak5 34 16 35
  • 86.36 (n)
rat
(Rattus norvegicus)
Mammalia LOC365985 34
  • 85.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AK5 35
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AK5 35
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves AK5 34 35
  • 75.94 (n)
lizard
(Anolis carolinensis)
Reptilia AK5 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ak5 34
  • 71.14 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100003595 34
  • 65.77 (n)
ak5 35
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Adk1 36 35
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea F38B2.4 36 35
  • 49 (a)
F13E6.2 34
  • 45.12 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes URA6 35
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4395 35
  • 38 (a)
OneToMany
Species where no ortholog for AK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AK5 Gene

ENSEMBL:
Gene Tree for AK5 (if available)
TreeFam:
Gene Tree for AK5 (if available)

Paralogs for AK5 Gene

Paralogs for AK5 Gene

(4) SIMAP similar genes for AK5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AK5: view

Variants for AK5 Gene

Sequence variations from dbSNP and Humsavar for AK5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1010061 -- 77,346,523(+) ATAGG(A/G)TCTGG intron-variant
rs1010195 -- 77,349,834(+) CGAAC(A/G)TAAAA intron-variant
rs1010196 -- 77,349,881(+) CTTGT(C/T)TCCCT intron-variant
rs10127564 -- 77,470,875(+) tatat(A/T)ttttt intron-variant
rs1013399 -- 77,529,308(+) cttaa(C/T)aggtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AK5 Gene

Variant ID Type Subtype PubMed ID
nsv823254 CNV loss 20364138
nsv818234 CNV loss 17921354
nsv546592 CNV loss 21841781
nsv546591 CNV gain 21841781
nsv521371 CNV loss 19592680
nsv517088 CNV loss 19592680
nsv470719 CNV gain 18288195
nsv462095 CNV loss 19166990
nsv441697 CNV loss 18776908
nsv1533 CNV deletion 18451855
nsv1522 CNV insertion 18451855
nsv1133132 CNV tandem duplication 24896259
nsv1122369 CNV deletion 24896259
esv9520 OTHER inversion 19470904
esv3893745 CNV gain 25118596
esv3586526 CNV loss 21293372
esv3586524 CNV loss 21293372
esv3586522 CNV loss 21293372
esv3586521 CNV loss 21293372
esv3586520 CNV loss 21293372
esv3577974 CNV loss 25503493
esv3564482 CNV deletion 23714750
esv3336566 CNV insertion 20981092
esv2764210 CNV loss 21179565
esv2762157 CNV loss 21179565
esv2758945 CNV loss 17122850
esv2750152 CNV deletion 23290073
esv2676174 CNV deletion 23128226
esv2670780 CNV deletion 23128226
esv2659731 CNV deletion 23128226
esv2657556 CNV deletion 23128226
esv2656843 CNV deletion 23128226
esv22538 CNV loss 19812545
esv1440178 CNV deletion 17803354
esv1179842 CNV deletion 17803354

Variation tolerance for AK5 Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AK5 Gene

Human Gene Mutation Database (HGMD)
AK5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AK5 Gene

Disorders for AK5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for AK5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
anterograde amnesia
  • amnesia, anterograde
prosopagnosia
limbic encephalitis
connective tissue cancer
  • connective tissue neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search AK5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AK5

Genetic Association Database (GAD)
AK5
Human Genome Epidemiology (HuGE) Navigator
AK5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AK5
genes like me logo Genes that share disorders with AK5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AK5 Gene

Publications for AK5 Gene

  1. Identification of two active functional domains of human adenylate kinase 5. (PMID: 19647735) Solaroli N. … Karlsson A. (FEBS Lett. 2009) 3 4 22 64
  2. Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein. (PMID: 10215863) Van Rompay A.R. … Karlsson A. (Eur. J. Biochem. 1999) 2 3 4 64
  3. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. (PMID: 23416111) Amiri M. … Solaroli N. (Int. J. Biochem. Cell Biol. 2013) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for AK5 Gene

Sources for AK5 Gene

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