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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AK5 Gene

protein-coding GIFtS: 61
GCID: GC01P077747

adenylate kinase 5

Explore 5 diseases affiliated with
AK5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adenylate Kinase 5¹ ²		Adenylate Kinase 6²
AK 5² ³		Adenylate Kinase Isoenzyme 5²
ATP-AMP Transphosphorylase 5² ³		EC 2.7.4.3³
AK6²

External Ids:	HGNC: 365¹	Entrez Gene: 26289²	Ensembl: ENSG00000154027⁷	OMIM: 608009⁵	UniProtKB: Q9Y6K8³

Export aliases for AK5 gene to outside databases

Previous GC identifers: GC01P078086 GC01P076692 GC01P077152 GC01P077170 GC01P077459 GC01P075878

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AK5:

This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide

composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This

member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in

brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KAD5_HUMAN, Q9Y6K8

Function: Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates

AMP, CMP, and to a small extent dCMP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AK5 gene promoter:
AREB6 Pax-5 NF-kappaB2 NF-kappaB1 NF-kappaB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AK5 promoter sequence

Search SABiosciences Chromatin IP Primers for AK5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AK5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31 Ensembl cytogenetic band: 1p31.1 HGNC cytogenetic band: 1p31

AK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AK5 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P077747: view genomic region (about GC identifiers)

Start:	77,747,736 bp from pter	End:	78,025,654 bp from pter
Size:	277,919 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KAD5_HUMAN, Q9Y6K8 (See protein sequence)

Recommended Name: Adenylate kinase isoenzyme 5

Size: 562 amino acids; 63333 Da

Subunit: Monomer (By similarity)

Subcellular location: Cytoplasm

1 PDB 3D structure from and Proteopedia for AK5:

2BWJ (3D)

Secondary accessions: Q5U622 Q6FH66 Q7Z4T5 Q86YS0 Q8N464 Q96EC9

Alternative splicing: 3 isoforms: Q9Y6K8-1 Q9Y6K8-2 Q9Y6K8-3 (It is unsure whether Met-1 or Met-5 is the initiator)

Explore the universe of human proteins at neXtProt for AK5: NX_Q9Y6K8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y6K8

AK5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_036225.2 NP_777283.1

ENSEMBL proteins:

ENSP00000346577 ENSP00000341430 ENSP00000434409 ENSP00000436859 ENSP00000433915

Reactome Protein details: Q9Y6K8
Human Recombinant Protein Products:

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	Novus Biologicals AK5 Proteins Novus Biologicals AK5 Lysates
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	ProSpec Recombinant Protein for AK5
	Uscn Proteins for AK5

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005813	centrosome	IDA	--
GO:0005829	cytosol	TAS	--

AK5 for ontologies About GeneDecksing

AK5 Antibody Products:

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	Novus Biologicals AK5 Antibodies
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	ThermoFisher Antibody for AK5

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	Uscn ELISAs and CLIAs for AK5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AK5 for domains About GeneDecksing

4 InterPro domains/families:

IPR003117 cAMP_dep_PK_reg_su_I/II_a/b

IPR000850 Adenylate_kin

IPR006267 Adenylate_kin1

IPR007858 Dpy-30_motif

Graphical View of Domain Structure for InterPro Entry Q9Y6K8

ProtoNet protein and cluster: Q9Y6K8

1 Blocks protein family: IPB000850 Adenylate kinase

UniProtKB/Swiss-Prot: KAD5_HUMAN, Q9Y6K8

Similarity: Belongs to the adenylate kinase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KAD5_HUMAN, Q9Y6K8

Function: Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates

AMP, CMP, and to a small extent dCMP

Catalytic activity: ATP + AMP = 2 ADP

Genatlas biochemistry entry for AK5:

adenylate kinase 5,located in the cytosol,expressed exclusively in brain

Enzyme Number (IUBMB): EC 2.7.4.3¹

miRNA Products:		OriGene 3'-UTR Clone (see all 2): AK5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AK5
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate AK5 (see all 9):
		hsa-miR-4303 hsa-miR-3166 hsa-miR-520a-5p hsa-miR-888* hsa-miR-525-5p hsa-miR-494 hsa-miR-302f hsa-miR-493*

		SwitchGear 3'UTR luciferase reporter plasmid: AK5 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AK5 (see all 3) OriGene shRNA RFP: AK5 OriGene siRNA: AK5
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for AK5

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		GenScript: all cDNA clones in your preferred vector (see all 2): AK5 (NM_012093)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AK5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for AK5
		Search LifeMap BioReagents cell lines for AK5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AK5

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004017	adenylate kinase activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0008603	cAMP-dependent protein kinase regulator activity	IEA	--
GO:0019205	nucleobase-containing compound kinase activity	--	--
GO:0019206	nucleoside kinase activity	EXP	--

AK5 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for AK5:

Increased Salmonella enterica

Increased apoptosis

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

ATP/ITP metabolism

ATP/ITP metabolism

1.00

ATP/ITP metabolism

0.98

G-protein signaling_G-Protein alpha-i signaling cascades

G-protein signaling G-Protein alpha-s signaling cascades

0.44

G-protein signaling_G-Protein alpha-s signaling cascades

0.44

Synthesis and interconversion of nucleotide di- and triphosphates

Synthesis and interconversion of nucleotide di- and triphosphates

1.00

AMPK Enzyme Complex Pathway

AMPK Enzyme Complex Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for AK5

	G-protein signaling G-Protein alpha-s signaling cascades
	ATP/ITP metabolism

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AK5

	Cholera Infection
	AMPK Enzyme Complex Pathway

2 GeneGo (Thomson Reuters) Pathways for AK5

	G-protein signaling G-Protein alpha-s signaling cascades
	ATP/ITP metabolism

3 Reactome Pathways for AK5

	Metabolism of nucleotides
	Synthesis and interconversion of nucleotide di- and triphosphates
	Metabolism

2 Kegg Pathways (Kegg details for AK5):

	Purine metabolism
	Metabolic pathways

AK5 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for AK5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/60 Interacting proteins for AK5 (Q9Y6K8³ ENSP00000346577⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 60)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BUD13	Q9BRD0³	I2D: score=5
C7orf26	Q96N11³	I2D: score=4
CPNE6	O95741³	I2D: score=4
NUCKS1	Q9H1E3³	I2D: score=4
RNF114	Q9Y508³	I2D: score=4

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006139	nucleobase-containing compound metabolic process	--	--
GO:0006172	ADP biosynthetic process	TAS	10215863
GO:0006173	dADP biosynthetic process	TAS	10215863
GO:0007165	signal transduction	IEA	--
GO:0009165	nucleotide biosynthetic process	--	--

AK5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

AK5 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AK5

6 HMDB Compounds for AK5 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Deoxyadenosine monophosphate	2'-Deoxy-5'-adenylate (see all 24)	653-63-4	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--
dADP	2'-deoxyadenosine-5'-diphosphate (see all 3)	2793-06-8	--

1 Novoseek chemical compound relationship for AK5 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
adenylate	62.8	7	19647735 (2), 17462746 (2), 20035430 (1), 18793766 (1) (see all 6)

Search CenterWatch for drugs/clinical trials and news about AK5 / KAD5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AK5 gene (2 alternative transcripts):

NM_012093.3 NM_174858.2

Unigene Cluster for AK5:

Adenylate kinase 5

Hs.559718 [show with all ESTs]

Unigene Representative Sequence: NM_012093

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000354567(uc001dhn.3) ENST00000317704(uc001dhm.2) ENST00000344720(uc001dho.3)

ENST00000478407 ENST00000469394 ENST00000466114 ENST00000524494 ENST00000465146

ENST00000530826 ENST00000527263 ENST00000478255 ENST00000466393 ENST00000531672

miRNA Products:		OriGene 3'-UTR Clone (see all 2): AK5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AK5
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate AK5 (see all 9):
		hsa-miR-4303 hsa-miR-3166 hsa-miR-520a-5p hsa-miR-888* hsa-miR-525-5p hsa-miR-494 hsa-miR-302f hsa-miR-493*

		SwitchGear 3'UTR luciferase reporter plasmid: AK5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AK5 (see all 3) OriGene shRNA RFP: AK5 OriGene siRNA: AK5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AK5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AK5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AK5 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): AK5 (NM_012093)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AK5

Additional cDNA sequence:

AF062595.1 AF445193.1 AK090967.1 AK127119.1 AY171600.2 BC012467.2 BC033896.1 BC036666.1

CR541890.1

13 DOTS entries:

DT.100752390 DT.40131945 DT.86852643 DT.86852644 DT.95288555 DT.101967524 DT.101956187 DT.92428135

DT.92031837 DT.92428134 DT.92428136 DT.95156699 DT.95268081

24/89 AceView cDNA sequences (see all 89):

BG253115 AA448527 NM_174858 BQ014349 CR541890 BM853550 NM_012093 R34922

BC012467 BM825361 BU627320 BF056865 AA319811 AI336847 AI990820 BM704448

AI206647 BI549439 BC033896 AW665223 AF445193 BX645048 AI699896 BG682889

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for AK5 About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b
SP1:			-				-												-
SP2:							-												-
SP3:			-				-		-
SP4:

ECgene alternative splicing isoforms for AK5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AK5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

AK5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See AK5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AK5

SOURCE GeneReport for Unigene cluster: Hs.559718

UniProtKB/Swiss-Prot: KAD5_HUMAN, Q9Y6K8

Tissue specificity: Brain specific

SABiosciences Custom PCR Arrays for AK5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AK5 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AK5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AK5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for AK5 gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	AK5¹	adenylate kinase 5	76.01(n) 77.5(a)		424555 XM_422391.3 XP_422391.2
lizard (Anolis carolinensis)	Reptilia	AK5⁶	--	76(a)	1 ↔ 1	GL343194.1(4413542-4542205)
zebrafish (Danio rerio)	Actinopterygii	LOC100003595¹	novel protein similar to vertebrate adenylate cyclase more	65.83(n) 64.64(a)		100003595 NM_001100084.1 NP_001093554.1
fruit fly (Drosophila melanogaster)	Insecta	Adk1³	adenylate kinase	46(a)		69A2 --
worm (Caenorhabditis elegans)	Secernentea	F38B2.4³ F13E6.2¹	adenylate kinase³ Protein F13E6.2¹	49(a)³ 43.65(n)¹ 28.66(a)¹		X(11321946-11322944)³ 181264¹ NM_077385.3¹ NP_509786.2¹

ENSEMBL Gene Tree for AK5 (if available)
TreeFam Gene Tree for AK5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for AK5 gene

AK1² LOC390877² CMPK1²

4 SIMAP similar genes for AK5 using alignment to 4 protein entries: KAD5_HUMAN (see all proteins):

AK1 AK2 CMPK1 CMPK

AK5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113619910^1,2	C	--	76157042(+)	`TGTATG/TTNNNN`	1	--	ut3¹		1		CSA	1
rs191619462^1,2		--	77745717(+)	`ATTTAC/GTGTTC`	1	--	us2k¹		0	--	--	--	--
rs184150872^1,2		--	77745826(+)	`TGCAAA/GAGTAA`	1	--	us2k¹		0	--	--	--	--
rs140280640^1,2		--	77745964(+)	`TACAAC/TTTTTA`	1	--	us2k¹		0	--	--	--	--
rs188820097^1,2		--	77746220(+)	`TACTTC/TTCAAG`	1	--	us2k¹		0	--	--	--	--
rs2004962^1,2	C,F,H,	--	77746245(-)	`AGTGTC/GTCTTC`	1	--	us2k¹ trp³		22		NS EA NA WA	2490
rs11807469^1,2	C,F,H,	--	77746265(+)	`ACTGCC/TATAGC`	1	--	us2k¹ tfbs³		8		NS NA WA	914
rs2799568^1,2	C,F,A,	--	77746521(+)	`AAAGAT/AGCACT`	2	--	us2k¹		10		NA WA CSA EA	371
rs181538959^1,2		--	77746549(+)	`CTCTAC/TAGTTT`	2	--	us2k¹		0	--	--	--	--
rs185382092^1,2		--	77746578(+)	`TTGCTC/TCTTTC`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for AK5 (77747736 - 77997736 bp, first 250kb of AK5)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for AK5
6 CNVs: 9885 2311 64059 48364 38184 84312
1 Inversion: 59655

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AK5

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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AK5 for disorders           About GeneDecksing

OMIM gene information: 608009    OMIM disorders: --

5 diseases for AK5:    About MalaCards

limbic encephalitis encephalitis histiocytoma noma

neuronitis

1 disease from the University of Copenhagen DISEASES database for AK5:

Histiocytoma

Human Genome Epidemiology (HuGE) Navigator: AK5 (2 documents)

Export disorders for AK5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for AK5 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with AK5)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein. (PubMed id 10215863)^{1, 2, 3} Van Rompay A.R.... Karlsson A. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of two active functional domains of hu man adenylate kinase 5. (PubMed id 19647735)^{1, 9} Solaroli N....Karlsson A. (2009)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPalpha. (PubMed id 18239623)¹ Bararia D....Behre G. (2008)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Dynamics of nucleotide metabolism as a supporter of life phenomena. (PubMed id 16167529)⁹ Noma T. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26289	HGNC: 365	AceView: AK5	Ensembl:ENSG00000154027	euGenes: HUgn26289
ECgene: AK5	Kegg: 26289	H-InvDB: AK5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for AK5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for AK5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for AK5 gene:
Search GeneIP for patents involving AK5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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