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Aliases for AK4 Gene

Aliases for AK4 Gene

  • Adenylate Kinase 4 2 3 5
  • Adenylate Kinase 3-Like 1 2 3
  • AK3L1 3 4
  • AK 4 3 4
  • AK3 3 4
  • GTP:AMP Phosphotransferase AK4, Mitochondrial 3
  • Adenylate Kinase Isoenzyme 4, Mitochondrial 3
  • Nucleoside-Triphosphate-Adenylate Kinase 3
  • Mitochondrial Adenylate Kinase-3 3
  • GTP:AMP Phosphotransferase AK4 4
  • ATP-AMP Transphosphorylase 3
  • Adenylate Kinase 3-Like 4
  • Adenylate Kinase 3 2
  • EC 2.7.4.10 4
  • EC 2.7.4.3 63
  • EC 2.7.4.6 4
  • EC 2.7.4 63
  • AK3L2 3

External Ids for AK4 Gene

Previous HGNC Symbols for AK4 Gene

  • AK3
  • AK3L1

Previous GeneCards Identifiers for AK4 Gene

  • GC01P065614

Summaries for AK4 Gene

Entrez Gene Summary for AK4 Gene

  • This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for AK4 Gene

AK4 (Adenylate Kinase 4) is a Protein Coding gene. Among its related pathways are Purine metabolism and Metabolism. GO annotations related to this gene include GTP binding and adenylate kinase activity. An important paralog of this gene is AK3.

UniProtKB/Swiss-Prot for AK4 Gene

  • Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.

Gene Wiki entry for AK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AK4 Gene

Genomics for AK4 Gene

Regulatory Elements for AK4 Gene

Enhancers for AK4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AK4 on UCSC Golden Path with GeneCards custom track

Promoters for AK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AK4 on UCSC Golden Path with GeneCards custom track

Genomic Location for AK4 Gene

Chromosome:
1
Start:
65,147,549 bp from pter
End:
65,232,145 bp from pter
Size:
84,597 bases
Orientation:
Plus strand

Genomic View for AK4 Gene

Genes around AK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AK4 Gene

Proteins for AK4 Gene

  • Protein details for AK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27144-KAD4_HUMAN
    Recommended name:
    Adenylate kinase 4, mitochondrial
    Protein Accession:
    P27144
    Secondary Accessions:
    • B2R927
    • D3DQ62
    • Q6IBH4
    • Q6NXQ5
    • Q8IUU9

    Protein attributes for AK4 Gene

    Size:
    223 amino acids
    Molecular mass:
    25268 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for AK4 Gene

neXtProt entry for AK4 Gene

Proteomics data for AK4 Gene at MOPED

Post-translational modifications for AK4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AK4 Gene

Domains & Families for AK4 Gene

Gene Families for AK4 Gene

Suggested Antigen Peptide Sequences for AK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P27144

UniProtKB/Swiss-Prot:

KAD4_HUMAN :
  • Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
  • Belongs to the adenylate kinase family. AK3 subfamily.
Domain:
  • Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
Family:
  • Belongs to the adenylate kinase family. AK3 subfamily.
genes like me logo Genes that share domains with AK4: view

Function for AK4 Gene

Molecular function for AK4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=5.3 uM for AMP with ATP as phosphate donor {ECO:0000269 PubMed:19766732}; KM=1.4 uM for AMP with GTP as phosphate donor {ECO:0000269 PubMed:19766732}; KM=507 uM for dAMP with ATP as phosphate donor {ECO:0000269 PubMed:19766732}; Vmax=90 pmol/min/ug enzyme with AMP as substrate and ATP as phosphate donor {ECO:0000269 PubMed:19766732}; Vmax=80 pmol/min/ug enzyme with AMP as substrate and GTP as phosphate donor {ECO:0000269 PubMed:19766732}; Vmax=88 pmol/min/ug enzyme with dAMP as substrate and ATP as phosphate donor {ECO:0000269 PubMed:19766732};
UniProtKB/Swiss-Prot CatalyticActivity:
NTP + AMP = NDP + ADP.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function:
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.

Enzyme Numbers (IUBMB) for AK4 Gene

genes like me logo Genes that share phenotypes with AK4: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AK4 Gene

Localization for AK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AK4 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AK4 Gene COMPARTMENTS Subcellular localization image for AK4 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 2
chloroplast 1
nucleus 1

Gene Ontology (GO) - Cellular Components for AK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with AK4: view

Pathways & Interactions for AK4 Gene

genes like me logo Genes that share pathways with AK4: view

Pathways by source for AK4 Gene

Gene Ontology (GO) - Biological Process for AK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IDA 23416111
GO:0006172 ADP biosynthetic process IEA --
GO:0009142 nucleoside triphosphate biosynthetic process IDA 23416111
GO:0046034 ATP metabolic process IDA 19766732
GO:0046039 GTP metabolic process IDA 19766732
genes like me logo Genes that share ontologies with AK4: view

No data available for SIGNOR curated interactions for AK4 Gene

Drugs & Compounds for AK4 Gene

(5) Drugs for AK4 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adefovir Dipivoxil Approved, Investigational Pharma Enzyme, substrate 131
Tenofovir Approved, Investigational Pharma Enzyme, substrate HIV reverse transcriptase inhibitor 701
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(4) Additional Compounds for AK4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
2793-06-8
Deoxyadenosine monophosphate
  • 2'-dAMP
  • 2'-Deoxy-5'-adenylate
  • 2'-Deoxy-5'-adenylic acid
  • 2'-Deoxy-Adenosine 5'-phosphorate
  • 2'-Deoxy-Adenosine 5'-phosphoric acid
653-63-4
genes like me logo Genes that share compounds with AK4: view

Transcripts for AK4 Gene

mRNA/cDNA for AK4 Gene

Unigene Clusters for AK4 Gene

Adenylate kinase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AK4 Gene

No ASD Table

Relevant External Links for AK4 Gene

GeneLoc Exon Structure for
AK4
ECgene alternative splicing isoforms for
AK4

Expression for AK4 Gene

mRNA expression in normal human tissues for AK4 Gene

mRNA differential expression in normal tissues according to GTEx for AK4 Gene

This gene is overexpressed in Kidney - Cortex (x5.8).

Protein differential expression in normal tissues from HIPED for AK4 Gene

This gene is overexpressed in Kidney (17.1) and Heart (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AK4 Gene



SOURCE GeneReport for Unigene cluster for AK4 Gene Hs.10862

mRNA Expression by UniProt/SwissProt for AK4 Gene

P27144-KAD4_HUMAN
Tissue specificity: Highly expressed in kidney, moderately expressed in heart and liver and weakly expressed in brain.
genes like me logo Genes that share expression patterns with AK4: view

Protein tissue co-expression partners for AK4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for AK4 Gene

Orthologs for AK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AK4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AK4 35
  • 89.24 (n)
  • 93.72 (a)
AK4 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AK4 35
  • 92.08 (n)
  • 95.52 (a)
-- 36
  • 53 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ak4 35
  • 87.74 (n)
  • 90.13 (a)
Ak4 16
Ak4 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AK4 35
  • 99.55 (n)
  • 99.55 (a)
AK4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ak4 35
  • 85.2 (n)
  • 89.24 (a)
oppossum
(Monodelphis domestica)
Mammalia AK4 36
  • 40 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AK4 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves AK4 35
  • 75.64 (n)
  • 80.72 (a)
AK4 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AK4 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ak4 35
  • 71.92 (n)
  • 77.93 (a)
zebrafish
(Danio rerio)
Actinopterygii ak4 35
  • 66.51 (n)
  • 66.36 (a)
ak4 36
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4221 35
fruit fly
(Drosophila melanogaster)
Insecta Adk3 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZK673.2 36
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADK2 36
  • 40 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8262 36
  • 45 (a)
OneToMany
Species with no ortholog for AK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AK4 Gene

ENSEMBL:
Gene Tree for AK4 (if available)
TreeFam:
Gene Tree for AK4 (if available)

Paralogs for AK4 Gene

Paralogs for AK4 Gene

(2) SIMAP similar genes for AK4 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for AK4 Gene

genes like me logo Genes that share paralogs with AK4: view

Variants for AK4 Gene

Sequence variations from dbSNP and Humsavar for AK4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs9092 -- 65,226,873(+) TTGCT(C/T)TTATC utr-variant-3-prime
rs11016 -- 65,231,784(-) TCTGT(C/T)CATCT utr-variant-3-prime
rs13483 -- 65,228,397(+) TCCCT(C/T)TTCCC utr-variant-3-prime
rs1109374 -- 65,167,814(+) TTTTT(C/T)CCCCT intron-variant
rs1125091 -- 65,174,656(+) GAATT(A/T)CGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AK4 Gene

Variant ID Type Subtype PubMed ID
esv2676423 CNV Deletion 23128226
nsv522027 CNV Loss 19592680
nsv871049 CNV Gain 21882294
esv2446769 CNV Deletion 19546169
esv2230166 CNV Deletion 18987734
esv2658072 CNV Deletion 23128226

Variation tolerance for AK4 Gene

Residual Variation Intolerance Score: 48.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.29; 81.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AK4 Gene

Disorders for AK4 Gene

Relevant External Links for AK4

Human Genome Epidemiology (HuGE) Navigator
AK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AK4

No disorders were found for AK4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AK4 Gene

Publications for AK4 Gene

  1. Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix. (PMID: 11485571) Noma T. … Yoshinobu K. (Biochem. J. 2001) 2 3 4 23 67
  2. Cloning and functional characterization of the promoter region of the gene encoding human adenylate kinase isozyme 3. (PMID: 10544043) Noma T. … Nakazawa A. (Biochem. Biophys. Res. Commun. 1999) 3 23
  3. Identification of a novel adenylate kinase system in the brain: cloning of the fourth adenylate kinase. (PMID: 9813319) Yoneda T. … Takagi H. (Brain Res. Mol. Brain Res. 1998) 3 23
  4. Characterization of human adenylate kinase 3 (AK3) cDNA and mapping of the AK3 pseudogene to an intron of the NF1 gene. (PMID: 1639383) Xu G. … White R. (Genomics 1992) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for AK4 Gene

Sources for AK4 Gene

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