Aliases for AK4 Gene
External Ids for AK4 Gene
Previous HGNC Symbols for AK4 Gene
Previous GeneCards Identifiers for AK4 Gene
This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]
GeneCards Summary for AK4 Gene
AK4 (Adenylate Kinase 4) is a Protein Coding gene. Among its related pathways are Tenofovir/Adefovir Pathway, Pharmacokinetics and Thiamine metabolism. GO annotations related to this gene include GTP binding and adenylate kinase activity. An important paralog of this gene is AK3.
UniProtKB/Swiss-Prot for AK4 Gene
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.