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Aliases for AK4 Gene

Aliases for AK4 Gene

  • Adenylate Kinase 4 2 3
  • AK3 3 4 6
  • Adenylate Kinase 3-Like 1 2 3
  • AK3L1 3 4
  • AK 4 3 4
  • GTP:AMP Phosphotransferase AK4, Mitochondrial 3
  • Adenylate Kinase Isoenzyme 4, Mitochondrial 3
  • Nucleoside-Triphosphate-Adenylate Kinase 3
  • Adenylate Kinase 4, Mitochondrial 3
  • Mitochondrial Adenylate Kinase-3 3
  • GTP:AMP Phosphotransferase AK4 4
  • ATP-AMP Transphosphorylase 3
  • Adenylate Kinase 3-Like 4
  • Adenylate Kinase 3 2
  • EC 2.7.4.10 4
  • EC 2.7.4.3 63
  • EC 2.7.4.6 4
  • EC 2.7.4 63
  • AK3L2 3

External Ids for AK4 Gene

Previous HGNC Symbols for AK4 Gene

  • AK3
  • AK3L1

Previous GeneCards Identifiers for AK4 Gene

  • GC01P065614

Summaries for AK4 Gene

Entrez Gene Summary for AK4 Gene

  • This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for AK4 Gene

AK4 (Adenylate Kinase 4) is a Protein Coding gene. Among its related pathways are Hemostasis and Metabolism. GO annotations related to this gene include GTP binding and adenylate kinase activity. An important paralog of this gene is AK8.

UniProtKB/Swiss-Prot for AK4 Gene

  • Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.

Gene Wiki entry for AK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AK4 Gene

Genomics for AK4 Gene

Genomic Location for AK4 Gene

Start:
65,147,549 bp from pter
End:
65,232,145 bp from pter
Size:
84,597 bases
Orientation:
Plus strand

Genomic View for AK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AK4 Gene

No data available for Regulatory Elements for AK4 Gene

Proteins for AK4 Gene

  • Protein details for AK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27144-KAD4_HUMAN
    Recommended name:
    Adenylate kinase 4, mitochondrial
    Protein Accession:
    P27144
    Secondary Accessions:
    • B2R927
    • D3DQ62
    • Q6IBH4
    • Q6NXQ5
    • Q8IUU9

    Protein attributes for AK4 Gene

    Size:
    223 amino acids
    Molecular mass:
    25268 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for AK4 Gene

neXtProt entry for AK4 Gene

Proteomics data for AK4 Gene at MOPED

Post-translational modifications for AK4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AK4 Gene

Domains for AK4 Gene

Gene Families for AK4 Gene

HGNC:
  • AK :Adenylate kinases

Suggested Antigen Peptide Sequences for AK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P27144

UniProtKB/Swiss-Prot:

KAD4_HUMAN :
  • P27144
Domain:
  • Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis
Family:
  • Belongs to the adenylate kinase family. AK3 subfamily.
genes like me logo Genes that share domains with AK4: view

Function for AK4 Gene

Molecular function for AK4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=5.3 uM for AMP with ATP as phosphate donor {ECO:0000269 PubMed:19766732}; KM=1.4 uM for AMP with GTP as phosphate donor {ECO:0000269 PubMed:19766732}; KM=507 uM for dAMP with ATP as phosphate donor {ECO:0000269 PubMed:19766732}; Vmax=90 pmol/min/ug enzyme with AMP as substrate and ATP as phosphate donor {ECO:0000269 PubMed:19766732}; Vmax=80 pmol/min/ug enzyme with AMP as substrate and GTP as phosphate donor {ECO:0000269 PubMed:19766732}; Vmax=88 pmol/min/ug enzyme with dAMP as substrate and ATP as phosphate donor {ECO:0000269 PubMed:19766732};
UniProtKB/Swiss-Prot CatalyticActivity: NTP + AMP = NDP + ADP.
UniProtKB/Swiss-Prot CatalyticActivity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.

Enzyme Numbers (IUBMB) for AK4 Gene

Gene Ontology (GO) - Molecular Function for AK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004017 NOT adenylate kinase activity IDA 11485571
GO:0004550 nucleoside diphosphate kinase activity IDA 23416111
GO:0005524 ATP binding IEA --
GO:0005525 GTP binding IEA --
GO:0016776 phosphotransferase activity, phosphate group as acceptor --
genes like me logo Genes that share ontologies with AK4: view

Animal Model Products

CRISPR Products

miRNA for AK4 Gene

miRTarBase miRNAs that target AK4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AK4

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AK4 Gene

Localization for AK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AK4 Gene

Mitochondrion matrix.

Gene Ontology (GO) - Cellular Components for AK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005759 mitochondrial matrix ISS 11485571
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with AK4: view

No data available for Subcellular locations from COMPARTMENTS for AK4 Gene

Pathways for AK4 Gene

genes like me logo Genes that share pathways with AK4: view

Pathways by source for AK4 Gene

Gene Ontology (GO) - Biological Process for AK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0006165 nucleoside diphosphate phosphorylation IDA 23416111
GO:0006172 ADP biosynthetic process IEA --
GO:0007420 brain development IEA --
GO:0009142 nucleoside triphosphate biosynthetic process IDA 23416111
genes like me logo Genes that share ontologies with AK4: view

Compounds for AK4 Gene

(5) HMDB Compounds for AK4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
dADP
  • 2'-deoxyadenosine-5'-diphosphate
2793-06-8
Deoxyadenosine monophosphate
  • 2'-Deoxy-5'-adenylate
653-63-4

(2) Novoseek inferred chemical compound relationships for AK4 Gene

Compound -log(P) Hits PubMed IDs
adenylate 68.5 8
adenine 49.9 2
genes like me logo Genes that share compounds with AK4: view

Transcripts for AK4 Gene

mRNA/cDNA for AK4 Gene

Unigene Clusters for AK4 Gene

Adenylate kinase 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AK4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AK4 Gene

No ASD Table

Relevant External Links for AK4 Gene

GeneLoc Exon Structure for
AK4
ECgene alternative splicing isoforms for
AK4

Expression for AK4 Gene

mRNA expression in normal human tissues for AK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AK4 Gene

This gene is overexpressed in Kidney - Cortex (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AK4 Gene

SOURCE GeneReport for Unigene cluster for AK4 Gene Hs.10862

mRNA Expression by UniProt/SwissProt for AK4 Gene

P27144-KAD4_HUMAN
Tissue specificity: Highly expressed in kidney, moderately expressed in heart and liver and weakly expressed in brain.
genes like me logo Genes that share expressions with AK4: view

In Situ Assay Products

Orthologs for AK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AK4 35
  • 99.55 (n)
  • 99.55 (a)
AK4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AK4 35
  • 89.24 (n)
  • 93.72 (a)
AK4 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 53 (a)
ManyToMany
AK4 35
  • 92.08 (n)
  • 95.52 (a)
mouse
(Mus musculus)
Mammalia Ak4 35
  • 87.74 (n)
  • 90.13 (a)
Ak4 16
Ak4 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AK4 36
  • 40 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AK4 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ak4 35
  • 85.2 (n)
  • 89.24 (a)
chicken
(Gallus gallus)
Aves AK4 35
  • 75.64 (n)
  • 80.72 (a)
AK4 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AK4 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ak4 35
  • 71.92 (n)
  • 77.93 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4221 35
zebrafish
(Danio rerio)
Actinopterygii ak4 35
  • 66.51 (n)
  • 66.36 (a)
ak4 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Adk3 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZK673.2 36
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADK2 36
  • 40 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8262 36
  • 45 (a)
OneToMany
Species with no ortholog for AK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AK4 Gene

ENSEMBL:
Gene Tree for AK4 (if available)
TreeFam:
Gene Tree for AK4 (if available)

Paralogs for AK4 Gene

Paralogs for AK4 Gene

Selected SIMAP similar genes for AK4 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for AK4 Gene

genes like me logo Genes that share paralogs with AK4: view

Variants for AK4 Gene

Sequence variations from dbSNP and Humsavar for AK4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9092 -- 65,226,873(+) TTGCT(C/T)TTATC utr-variant-3-prime
rs11016 -- 65,231,784(-) TCTGT(C/T)CATCT utr-variant-3-prime
rs1062445 -- 65,229,136(+) CTCCA(A/G)CCCAG utr-variant-3-prime
rs1072864 -- 65,232,159(-) AGCTA(C/T)ACAAA downstream-variant-500B
rs1109374 -- 65,167,814(+) TTTTT(C/T)CCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AK4 Gene

Variant ID Type Subtype PubMed ID
esv2676423 CNV Deletion 23128226
nsv522027 CNV Loss 19592680
nsv871049 CNV Gain 21882294
esv2446769 CNV Deletion 19546169
esv2230166 CNV Deletion 18987734
esv2658072 CNV Deletion 23128226

Relevant External Links for AK4 Gene

HapMap Linkage Disequilibrium report
AK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AK4 Gene

Disorders for AK4 Gene

Relevant External Links for AK4

Human Genome Epidemiology (HuGE) Navigator
AK4
genes like me logo Genes that share disorders with AK4: view

No data available for UniProtKB/Swiss-Prot for AK4 Gene

Publications for AK4 Gene

  1. Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix. (PMID: 11485571) Noma T. … Yoshinobu K. (Biochem. J. 2001) 2 3 4 23
  2. Characterization of human adenylate kinase 3 (AK3) cDNA and mapping of the AK3 pseudogene to an intron of the NF1 gene. (PMID: 1639383) Xu G. … White R. (Genomics 1992) 3 4 23
  3. Identification of a novel adenylate kinase system in the brain: cloning of the fourth adenylate kinase. (PMID: 9813319) Yoneda T. … Takagi H. (Brain Res. Mol. Brain Res. 1998) 3 23
  4. Cloning and functional characterization of the promoter region of the gene encoding human adenylate kinase isozyme 3. (PMID: 10544043) Noma T. … Nakazawa A. (Biochem. Biophys. Res. Commun. 1999) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for AK4 Gene

  • Addgene plasmids for AK4

Sources for AK4 Gene

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