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Aliases for AK3 Gene

Aliases for AK3 Gene

  • Adenylate Kinase 3 2 3 4 5
  • Adenylate Kinase 3 Alpha-Like 1 3 4
  • EC 2.7.4.10 4 63
  • AK3L1 3 4
  • AKL3L 3 4
  • AK6 3 4
  • Adenylate Kinase 6, Adenylate Kinase 3 Like 1 3
  • GTP:AMP Phosphotransferase, Mitochondrial 3
  • Adenylate Kinase 3 Like 1 2
  • Adenylate Kinase 6 2
  • EC 2.7.4 63
  • AKL3L1 3
  • AK 3 4
  • FIX 3

External Ids for AK3 Gene

Previous HGNC Symbols for AK3 Gene

  • AK6
  • AK3L1

Previous GeneCards Identifiers for AK3 Gene

  • GC01P065564
  • GC01P064533
  • GC01P064970
  • GC01P064983
  • GC01P065326

Summaries for AK3 Gene

Entrez Gene Summary for AK3 Gene

  • The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for AK3 Gene

AK3 (Adenylate Kinase 3) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Gene Expression. GO annotations related to this gene include GTP binding and phosphotransferase activity, phosphate group as acceptor. An important paralog of this gene is AK4.

UniProtKB/Swiss-Prot for AK3 Gene

  • Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AK3 Gene

Genomics for AK3 Gene

Regulatory Elements for AK3 Gene

Promoters for AK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for AK3 Gene

Chromosome:
9
Start:
4,709,556 bp from pter
End:
4,742,043 bp from pter
Size:
32,488 bases
Orientation:
Minus strand

Genomic View for AK3 Gene

Genes around AK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AK3 Gene

Proteins for AK3 Gene

  • Protein details for AK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIJ7-KAD3_HUMAN
    Recommended name:
    GTP:AMP phosphotransferase AK3, mitochondrial
    Protein Accession:
    Q9UIJ7
    Secondary Accessions:
    • B4DP58
    • D3DRI1
    • E7ET30
    • Q5VYW6
    • Q9H576
    • Q9HC01
    • Q9NPB4

    Protein attributes for AK3 Gene

    Size:
    227 amino acids
    Molecular mass:
    25565 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for AK3 Gene

    Alternative splice isoforms for AK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AK3 Gene

Proteomics data for AK3 Gene at MOPED

Post-translational modifications for AK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for AK3 Gene

Gene Families for AK3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UIJ7

UniProtKB/Swiss-Prot:

KAD3_HUMAN :
  • Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
  • Belongs to the adenylate kinase family. AK3 subfamily.
Domain:
  • Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
Family:
  • Belongs to the adenylate kinase family. AK3 subfamily.
genes like me logo Genes that share domains with AK3: view

Function for AK3 Gene

Molecular function for AK3 Gene

GENATLAS Biochemistry:
adenylate kinase 3,mitochondrial matrix adenine nucleotide catabolic pathway and guanine nucleotide pools homeostasis
UniProtKB/Swiss-Prot CatalyticActivity:
NTP + AMP = NDP + ADP.
UniProtKB/Swiss-Prot Function:
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.

Enzyme Numbers (IUBMB) for AK3 Gene

Gene Ontology (GO) - Molecular Function for AK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019205 nucleobase-containing compound kinase activity IEA --
genes like me logo Genes that share ontologies with AK3: view
genes like me logo Genes that share phenotypes with AK3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AK3

miRNA for AK3 Gene

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AK3 Gene

Localization for AK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AK3 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AK3 Gene COMPARTMENTS Subcellular localization image for AK3 gene
Compartment Confidence
mitochondrion 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for AK3 Gene

Pathways & Interactions for AK3 Gene

genes like me logo Genes that share pathways with AK3: view

Pathways by source for AK3 Gene

Gene Ontology (GO) - Biological Process for AK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
GO:0046039 GTP metabolic process IDA 11485571
GO:0046041 ITP metabolic process IDA 11485571
genes like me logo Genes that share ontologies with AK3: view

No data available for SIGNOR curated interactions for AK3 Gene

Drugs & Compounds for AK3 Gene

(3) Drugs for AK3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Uridine triphosphate Experimental Pharma 0
Uridine-5'-Diphosphate Experimental Pharma 0

(3) Additional Compounds for AK3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
NTP
genes like me logo Genes that share compounds with AK3: view

Transcripts for AK3 Gene

Unigene Clusters for AK3 Gene

Adenylate kinase 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AK3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7:

Relevant External Links for AK3 Gene

GeneLoc Exon Structure for
AK3
ECgene alternative splicing isoforms for
AK3

Expression for AK3 Gene

mRNA expression in normal human tissues for AK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AK3 Gene

This gene is overexpressed in Liver, secretome (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AK3 Gene



SOURCE GeneReport for Unigene cluster for AK3 Gene Hs.732022

mRNA Expression by UniProt/SwissProt for AK3 Gene

Q9UIJ7-KAD3_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle and liver, moderately expressed in pancreas and kidney, and weakly expressed in placenta, brain and lung.
genes like me logo Genes that share expression patterns with AK3: view

Protein tissue co-expression partners for AK3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for AK3 Gene

Orthologs for AK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AK3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AK3 35
  • 89.87 (n)
  • 92.51 (a)
AK3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC480491 35
  • 91.19 (n)
  • 93.83 (a)
AK3 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ak3 35
  • 88.84 (n)
  • 92.51 (a)
Ak3 16
Ak3 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AK3 35
  • 99.63 (n)
  • 99.45 (a)
AK3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ak3 35
  • 87.81 (n)
  • 90.75 (a)
oppossum
(Monodelphis domestica)
Mammalia AK3 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AK3 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves AK3 35
  • 74.67 (n)
  • 73.33 (a)
AK3 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AK3 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15233 35
zebrafish
(Danio rerio)
Actinopterygii ak3 35
  • 65.27 (n)
  • 67.44 (a)
wufc20h08 35
ak3 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Adk3 37
  • 48 (a)
Adk3 35
  • 55.61 (n)
  • 50.71 (a)
Adk3 36
  • 50 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009660 35
  • 56.7 (n)
  • 56.19 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK673.2 37
  • 31 (a)
CELE_ZK673.2 35
  • 47.26 (n)
  • 37.81 (a)
ZK673.2 36
  • 33 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR115C 35
  • 47.51 (n)
  • 41.59 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C17754g 35
  • 51.27 (n)
  • 46.67 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADK2 35
  • 49.16 (n)
  • 46.46 (a)
ADK2 36
  • 41 (a)
OneToMany
ADK2 38
bread mold
(Neurospora crassa)
Ascomycetes NCU03216 35
  • 49.42 (n)
  • 44.28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8262 36
  • 49 (a)
OneToMany
Species with no ortholog for AK3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AK3 Gene

ENSEMBL:
Gene Tree for AK3 (if available)
TreeFam:
Gene Tree for AK3 (if available)

Paralogs for AK3 Gene

Paralogs for AK3 Gene

(2) SIMAP similar genes for AK3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AK3: view

Variants for AK3 Gene

Sequence variations from dbSNP and Humsavar for AK3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs6915 -- 4,711,440(+) CTATA(A/T)TTCTT utr-variant-3-prime
rs7839 -- 4,711,224(+) AAAGG(A/C)AGGTG utr-variant-3-prime
rs8525 -- 4,712,269(-) GATTT(A/C/G/T)TGTCA utr-variant-3-prime
rs10262 -- 4,712,245(+) TGTAA(A/G)AGCAC utr-variant-3-prime
rs12256 -- 4,711,367(+) TTTTT(C/T)AGAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for AK3 Gene

Variant ID Type Subtype PubMed ID
nsv892127 CNV Gain 21882294
nsv892128 CNV Gain 21882294
dgv8016n71 CNV Loss 21882294
esv2606673 CNV Insertion 19546169
nsv892131 CNV Loss 21882294
esv22952 CNV Gain 19812545
nsv892132 CNV Gain 21882294
nsv466096 CNV Loss 19166990
esv2669659 CNV Deletion 23128226
nsv824823 CNV Loss 20364138
esv2678066 CNV Deletion 23128226

Variation tolerance for AK3 Gene

Residual Variation Intolerance Score: 29.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 39.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AK3 Gene

HapMap Linkage Disequilibrium report
AK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AK3 Gene

Disorders for AK3 Gene

Relevant External Links for AK3

Genetic Association Database (GAD)
AK3
Human Genome Epidemiology (HuGE) Navigator
AK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AK3

No disorders were found for AK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AK3 Gene

Publications for AK3 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. Cloning and functional characterization of the promoter region of the gene encoding human adenylate kinase isozyme 3. (PMID: 10544043) Noma T. … Nakazawa A. (Biochem. Biophys. Res. Commun. 1999) 3 23
  3. Evidence for the assignment of the loci AK1, AK3 and ACONs to chromosome 9 in man. (PMID: 182062) Povey S. … Bobrow M. (Ann. Hum. Genet. 1976) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for AK3 Gene

Sources for AK3 Gene

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