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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AK3 Gene

protein-coding   GIFtS: 63
GCID: GC09M004703

adenylate kinase 3

(Previous names: adenylate kinase 6, adenylate kinase 3 like 1 )
(Previous symbols: AK6, AK3L1)
 Explore 9 diseases affiliated with
AK3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AK3    

Aliases
for AK3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Adenylate Kinase 31 2 3     Adenylate Kinase 3 Like 11
AK3L11 2 3     Adenylate Kinase 61
AK61 2 3     FIX2
AKL3L11 2     Adenylate Kinase 6, Adenylate Kinase 3 Like 12
Adenylate Kinase 3 Alpha-Like 12 3     GTP:AMP Phosphotransferase, Mitochondrial2
AKL3L2 3     AK 33
EC 2.7.4.103 8     EC 2.7.48

External Ids:    HGNC: 173761   Entrez Gene: 508082   Ensembl: ENSG000001478537   OMIM: 6092905   UniProtKB: Q9UIJ73   

Export aliases for AK3 gene to outside databases

Previous GC identifers: GC01P065564 GC01P064533 GC01P064970 GC01P064983 GC01P065326


Summaries
for AK3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AK3:
The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several
transcript variants encoding a few different isoforms have been found for this gene. (provided by RefSeq, Dec 2010)




Genomic Views
for AK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AK3 gene promoter:
         AP-2alpha isoform 3   AML1a   Pax-2   AP-2alpha isoform 2   Pax-2a   Evi-1   CREB   AP-2alpha isoform 4   Pax-4a   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for AK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24.1

AK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AK3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M004703:  view genomic region     (about GC identifiers)

Start:
 4,711,155 bp from pter      End:
 4,742,043 bp from pter
Size:
 30,889 bases      Orientation:
 minus strand

Proteins
for AK3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KAD3_HUMAN, Q9UIJ7 (See protein sequence)
Recommended Name: GTP:AMP phosphotransferase, mitochondrial  
Size: 227 amino acids; 25565 Da
Subunit: Monomer (By similarity)
Subcellular location: Mitochondrion matrix (By similarity)
1 PDB 3D structure from and Proteopedia for AK3:
1ZD8 (3D)    
Secondary accessions: B4DP58 D3DRI1 E7ET30 Q5VYW6 Q9H576 Q9HC01 Q9NPB4
Alternative splicing: 3 isoforms:  Q9UIJ7-1   Q9UIJ7-2   Q9UIJ7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AK3: NX_Q9UIJ7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UIJ7

    • 4/10 DME Specific Peptides for AK3 (Q9UIJ7) (see all 10)
     FSGTETN  DDKPETV  SSGDLLR  LDGFPRT 

    AK3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001186781.1  NP_001186782.1  NP_001186784.1  NP_001186785.1  NP_057366.2  

    ENSEMBL proteins: 
     ENSP00000371230   ENSP00000352948   ENSP00000413933   ENSP00000439177  
    Reactome Protein details: Q9UIJ7
    Human Recombinant Protein Products: 
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    Novus Biologicals AK3 Proteins
    Novus Biologicals AK3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for AK3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS--
    GO:0005759mitochondrial matrix TAS--


    AK3 for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for AK3

    Assay Products for AK3: 
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    Uscn ELISAs and CLIAs for AK3

    Protein Domains /
    Families
    for AK3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AK3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006259 Adenyl_kin_sub
     IPR000850 Adenylate_kin
     IPR007862 Adenylate_kinase_lid-dom

    Graphical View of Domain Structure for InterPro Entry Q9UIJ7

    ProtoNet protein and cluster: Q9UIJ7

    1 Blocks protein family: IPB000850 Adenylate kinase

    UniProtKB/Swiss-Prot: KAD3_HUMAN, Q9UIJ7
    Similarity: Belongs to the adenylate kinase family


    Function
    for AK3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KAD3_HUMAN, Q9UIJ7
    Catalytic activity: NTP + AMP = NDP + ADP

         Genatlas biochemistry entry for AK3:
    adenylate kinase 3,mitochondrial matrix adenine nucleotide catabolic pathway and guanine nucleotide pools homeostasis

    Enzyme Numbers (IUBMB): EC 2.7.4.101 2 EC 2.7.42

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AK3
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate AK3 (see all 41):
    hsa-miR-579 hsa-miR-607 hsa-miR-3607-3p hsa-miR-449a hsa-miR-124 hsa-miR-186 hsa-miR-506 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmid: AK3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AK3 (see all 7)
    OriGene shRNA RFP: AK3
    OriGene siRNA: AK3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AK3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for AK3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AK3 (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AK3 

    Cell Line
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    Search LifeMap BioReagents cell lines for AK3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AK3

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004017NOT adenylate kinase activity IDA11485571
    GO:0005524ATP binding IEA--
    GO:0005525GTP binding IEA--
    GO:0042802identical protein binding ----
    GO:0046899nucleoside triphosphate adenylate kinase activity IDA11485571


    AK3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for AK3:
     Decreased CYP1A1 activity afte  Increased cell number in G1, s 


    Pathways & Interactions
    for AK3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Factors involved in megakaryocyte development and platelet production
    		Factors involved in megakaryocyte development and platelet production1.00
    2Platelet activation, signaling and aggregation
    		Hemostasis0.43
    3Purine metabolism
    		Pyrimidine metabolism0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for AK3
        Hemostasis
    Factors involved in megakaryocyte development and platelet production


    1         Kegg Pathway  (Kegg details for AK3):
        Pyrimidine metabolism


    AK3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for AK3 (Q9UIJ73 ENSP000003712304) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOT1P171743I2D: score=1 
    CMPK1ENSP000003609394STRING: ENSP00000360939
    CMPK2ENSP000002567224STRING: ENSP00000256722
    CTPS1ENSP000003616994STRING: ENSP00000361699
    CTPS2ENSP000003522224STRING: ENSP00000352222
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006756AMP phosphorylation ----
    GO:0007596blood coagulation TAS--
    GO:0046033AMP metabolic process IDA11485571
    GO:0046039GTP metabolic process IDA11485571
    GO:0046041ITP metabolic process IDA11485571


    AK3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AK3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AK3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AK3

    4 HMDB Compounds for AK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine triphosphate5'-UTP (see all 7)63-39-8--
    1 Novoseek chemical compound relationship for AK3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 61.5 8 1639383 (2), 10544043 (2), 19278812 (1), 17203974 (1)

    Search CenterWatch for drugs/clinical trials and news about AK3 / KAD3 

    Transcripts
    for AK3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AK3 gene (6 alternative transcripts): 
    NM_001199852.1  NM_001199853.1  NM_001199855.1  NM_001199856.1  NM_016282.3  NM_001199854.1  

    Unigene Cluster for AK3:

    Adenylate kinase 3
    Hs.493362  [show with all ESTs]
    Unigene Representative Sequence: NM_016282
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381809(uc022bcz.1 uc011lma.2 uc003ziq.2 uc022bda.1 uc003zir.2)
    ENST00000359883 ENST00000447596 ENST00000474822

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AK3
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate AK3 (see all 41):
    hsa-miR-579 hsa-miR-607 hsa-miR-3607-3p hsa-miR-449a hsa-miR-124 hsa-miR-186 hsa-miR-506 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmid: AK3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AK3 (see all 7)
    OriGene shRNA RFP: AK3
    OriGene siRNA: AK3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AK3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AK3 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: AK3 (NM_000215)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AK3 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AK3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AK3

    Additional cDNA sequence: 

    AB021870.1 AF086913.1 AF100785.1 AF183419.1 AK001553.1 AK001951.1 AK027534.1 AK098205.1 
    AK124824.1 AK298200.1 BC013771.1 BX640794.1 

    21 DOTS entries:

    DT.97847612  DT.447231  DT.100687541  DT.100829000  DT.100667601  DT.92444498  DT.95271318  DT.121153150 
    DT.100839344  DT.121153154  DT.100645587  DT.121153156  DT.121153212  DT.95271339  DT.100829001  DT.100829005 
    DT.121153146  DT.121153168  DT.40258542  DT.75155943  DT.95349058 

    24/390 AceView cDNA sequences (see all 390):

    BE504414 BC013771 AI476266 BQ270605 CA944515 AI052134 BQ023459 NM_016282 
    BQ719719 BM272607 BX461238 AV727814 BM506713 CB123834 AV695155 CA393732 
    AU130170 BM142463 BP342636 AA431256 BM798749 AA564981 AL138385 AW959521 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AK3 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                                                              
    SP2:              -     -     -     -     -     -                                 
    SP3:                    -     -     -     -     -                                 
    SP4:                                -     -     -                                 
    SP5:                                -     -     -     -                           


    ECgene alternative splicing isoforms for AK3

    Expression
    for AK3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGAGACACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    AK3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See AK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AK3

    SOURCE GeneReport for Unigene cluster: Hs.493362
        SABiosciences Expression via Pathway-Focused PCR Array including AK3: 
              Cardiotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AK3

    Orthologs
    for AK3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for AK3 gene from 7/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves AK31 adenylate kinase 3 74.81(n)
    74.21(a)    		   426534  XM_424173.3  XP_424173.3 
    lizard
    (Anolis carolinensis)    		 Reptilia AK36
    		 --
    		 69(a)
    		 1 ↔ 1
    		 2(52100619-52112933)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.152332 Transcribed sequence with weak similarity to protein more 75.38(n)    BX702100.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc20h082 Danio rerio cDNA clone MGC64135 IMAGE6796870, complete more 75.24(n)    BC053273.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Adk31 , 3 adenylate kinase3
    Adenylate kinase-31    		 48(a)3
    55.61(n)1
    50.71(a)1    		   86C73
    413181  NM_079588.31  NP_524312.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea ZK673.23
    CELE_ZK673.21    		 adenylate kinase3
    Protein ZK673.21    		 31(a)3
    47.43(n)1
    37.81(a)1    		   II(10447856-10450117)3
    1746081  NM_063844.31  NP_496245.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes ADK2(YER170W)4
    ADK21    		 Mitochondrial adenylate kinase, catalyzes the reversible more4
    Adk2p1    		 50(n)1
    47.96(a)1    		   5(525974-526651)4
    8569171, 4  NP_011097.31  NP_011097.14 


    ENSEMBL Gene Tree for AK3 (if available)
    TreeFam Gene Tree for AK3 (if available) 

    Paralogs
    for AK3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AK3 gene
    AK82  AK42  
    2 SIMAP similar genes for AK3 using alignment to 1 protein entry:     KAD3_HUMAN:
    AK4    AK2

    AK3 for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for AK3 (see all 7)
    PGOHUM00000238717 PGOHUM00000239611 PGOHUM00000238040 PGOHUM00000235732 PGOHUM00000233148


    Genomic Variants
    for AK3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1091 NCBI SNPs in AK3 are shown (see all 1091)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs755244941,2
    		C,F,--4664471(+) GTACTT/CGTCTG 5 -- ds50011Minor allele frequency- C:0.09WA 118
    rs120033841,2
    		C,F,H,--4664724(+) ATGAAG/ATGAAA 5 -- ds50016Minor allele frequency- A:0.01NS EA NA CSA 404
    rs10480201,2
    		C,F,O,A,H,--4665129(-) AGAAAT/CAGCTT 5 -- ut3121Minor allele frequency- C:0.09MN NS EA NA WA 2160
    rs3014921,2
    		C,F,A,--4665206(-) AGAATA/GTGTTG 5 -- ut318Minor allele frequency- G:0.43MN WA NA CSA EA 549
    rs70287111,2
    		C,--4665592(+) ctgtcG/Tcccag 5 -- ut310--------
    rs78575821,2
    		C,F--4665755(+) agagaC/Tggggt 5 -- ut312Minor allele frequency- T:0.50NA 4
    rs3014911,2
    		A,--4665800(-) atcacG/Aaggtc 5 -- ut311Minor allele frequency- A:0.00NA 2
    rs714964891,2
    		C,F,--4665808(+) GATCCG/ACCCGC 5 -- ut314Minor allele frequency- A:0.50NA WA 8
    rs714964901,2
    		C,F,--4665811(+) CCGCCC/TGCCTC 5 -- ut313Minor allele frequency- T:0.50NA WA 6
    rs714964911,2
    		C,F,--4665814(+) CCCGCC/TTCGGC 5 -- ut314Minor allele frequency- T:0.50NA WA 8

    HapMap Linkage Disequilibrium report for AK3 (4711155 - 4742043 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for AK3
         1 CNV: 70511
         1 Indel: 100567

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    Disorders / Diseases
    for AK3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AK3 for disorders           About GeneDecksing

    OMIM gene information: 609290    OMIM disorders: --

    9 diseases for AK3:    About MalaCards
    nail-patella syndrome    astigmatism    noma    hepatocellular carcinoma
    pneumonia    tuberculosis    carcinoma    leukemia
    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: AK3 (3 documents)

    Export disorders for AK3 gene to outside databases

    Publications
    for AK3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AK3 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with AK3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Evidence for the assignment of the loci AK1, AK3 and ACONs to chromosome 9 in man. (PubMed id 182062)1, 3 Povey S....Bobrow M. (1976)
    5. Cloning and functional characterization of the promoter region of the gene encoding human adenylate kinase isozyme 3. (PubMed id 10544043)1, 9 Noma T....Nakazawa A. (1999)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. New gene functions in megakaryopoiesis and platelet fo rmation. (PubMed id 22139419)1 Gieger C....Soranzo N. (2011)
    10. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)

    External Searches for AK3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing AK3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50808 HGNC: 17376 AceView: AK3L1 Ensembl:ENSG00000147853 euGenes: HUgn50808
    ECgene: AK3 Kegg: 50808 H-InvDB: AK3

    Other Databases showing AK3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AK3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AK3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for AK3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AK3 gene:
    Search GeneIP for patents involving AK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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