AK1 Gene
protein-coding GIFtS: 68
GCID: GC09M130628
|
|
adenylate kinase 1
| |
Aliases
for AK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adenylate Kinase 11 2 | | Adenylate Kinase Isoenzyme 12 | | AK 12 3 | | Myokinase3 | | ATP-AMP Transphosphorylase 12 3 | | Myokinase3 | | EC 2.7.4.33 8 | | EC 2.7.48 |
Export aliases for AK1 gene to outside databasesPrevious GC identifers: GC09M121743 GC09M122275 GC09M124082 GC09M126004 GC09M127708 GC09M129668 GC09M100246 |
Summaries
for AK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for AK1:
Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing thereversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have beenidentified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletalmuscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver andheart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolyticanemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. (provided by RefSeq,Jul 2008)
UniProtKB/Swiss-Prot: KAD1_HUMAN, P00568Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitousenzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth
|
Genomic Views
for AK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AK1 gene promoter:
c-Fos p53 AP-2alpha isoform 3 AP-1 AP-2alpha isoform 2 AP-2alpha isoform 4 c-Jun AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for AK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AK1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.1 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.1AK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M130628: view genomic region
(about GC identifiers)
Start:
|
130,628,759 bp from pter |
End:
|
130,640,022 bp from pter |
Size:
|
11,264 bases |
Orientation:
|
minus strand |
|
Proteins
for AK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KAD1_HUMAN, P00568 (See
protein sequence)Recommended Name: Adenylate kinase isoenzyme 1 Size: 194 amino acids; 21635 Da
Subunit: Monomer
Subcellular location: Cytoplasm
2 PDB 3D structures from  and Proteopedia  for AK1:1Z83 (3D)
2C95 (3D)
Secondary accessions: Q9BVK9 Q9UQC7Explore the universe of human proteins at neXtProt for AK1: NX_P00568
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P00568
4/9 DME Specific Peptides for AK1 (P00568) (see all 9)
AK1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000467.1
ENSEMBL proteins: ENSP00000362271 ENSP00000449130 ENSP00000392314 ENSP00000362249 ENSP00000223836 ENSP00000448741 Reactome Protein details: P00568
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
AK1 for ontologies About GeneDecksing
AK1 Antibody Products:
Assay Products for AK1: |
Protein
Domains /
Families
for AK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AK1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P00568ProtoNet protein and cluster: P00568 1 Blocks protein family: IPB000850 Adenylate kinase
UniProtKB/Swiss-Prot: KAD1_HUMAN, P00568Similarity: Belongs to the adenylate kinase family |
Function
for AK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KAD1_HUMAN, P00568Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitousenzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growthCatalytic activity: ATP + AMP = 2 ADP Genatlas biochemistry entry for AK1:adenylate kinase 1,cytosolic,expressed in erythrocyte,skeletal muscle,brain, responsible of the phosphorylation of AMPin RBC and production of ADP,adenine nucleotide catabolic pathway and guanine nucleotide pools homeostasis
Enzyme Numbers (IUBMB): EC 2.7.4.31 2 EC 2.7.42
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AK1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AK1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: AK1 (NM_000476) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AK1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AK1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004017 | adenylate kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- | | GO:0019205 | nucleobase-containing compound kinase activity |
-- | -- |
AK1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for AK1:
Animal Models:
Mouse knock-out Ak1tm1Bew for AK1
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ak1):
AK1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for AK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | | | 2 | ATP/ITP metabolism | | | 3 | G-protein signaling_G-Protein alpha-i signaling cascades | | | 4 | Synthesis and interconversion of nucleotide di- and triphosphates | | | 5 | AMPK Enzyme Complex Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for AK1
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AK1
2  GeneGo (Thomson Reuters) Pathways for AK1
3 
Reactome Pathways for AK1
2 
Kegg Pathways (Kegg details for AK1):
AK1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AK1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/62 Interacting proteins for AK1 (P005683 ENSP000003622494) via UniProtKB, MINT, STRING, and/or I2D (see all 62)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006139 | nucleobase-containing compound metabolic process |
-- | -- | | GO:0007050 | cell cycle arrest |
IEA | -- | | GO:0015949 | nucleobase-containing small molecule interconversion |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- | | GO:0046034 | ATP metabolic process |
IEA | -- |
AK1 for ontologies About GeneDecksing
|
Drugs & Compounds
for AK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
AK1 for compounds About GeneDecksing
 Browse Tocris compounds for AK1
5 HMDB Compounds for AK1 About this table
1 DrugBank Compound for AK1 About this table
10/14 Novoseek chemical compound relationships for AK1 gene (see all 14) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ddamp |
90.8 |
1 |
7945403 (1) |
| adenylate |
79.8 |
39 |
17704060 (2), 2018038 (2), 2168054 (2), 18446060 (2) (see all 28) |
| 6-phosphogluconate |
71 |
3 |
2129617 (1), 2129611 (1), 9463796 (1) |
| prpp |
58.4 |
2 |
7945403 (1) |
| adp |
51.3 |
7 |
1470606 (1), 9239671 (1), 17242488 (1), 1369982 (1) (see all 5) |
| citrate |
48.4 |
5 |
9694316 (1), 2289498 (1), 1400042 (1), 8036909 (1) (see all 5) |
| phosphocreatine |
47.9 |
4 |
9239671 (1), 2082717 (1), 11735686 (1) |
| atp |
43.6 |
13 |
18446060 (3), 1470606 (1), 17704060 (1), 9239671 (1) (see all 7) |
| creatinine |
36.4 |
7 |
9925374 (1), 11006295 (1), 2289498 (1), 2082717 (1) (see all 6) |
| lactate |
33.3 |
5 |
1455165 (1), 2289498 (1), 1400042 (1), 8036909 (1) (see all 5) |
Search CenterWatch for drugs/clinical trials and news about AK1 / KAD1
|
Transcripts
for AK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AK1 gene: NM_000476.2 Unigene Cluster for AK1: Adenylate kinase 1 Hs.175473 [show with all ESTs]Unigene Representative Sequence: NM_0004766 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373176(uc004bsm.4) ENST00000550143 ENST00000413016 ENST00000373156
ENST00000223836 ENST00000550992
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AK1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AK1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AK1 (NM_000476) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AK1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AK1 |
Additional cDNA sequence: AB021871.1 AK223501.1 AK313758.1 BC001116.2 BC100022.1 BT019580.1 CR541977.1 CR542004.1 12 DOTS entries: DT.100730360 DT.100790419 DT.218227 DT.91966343 DT.95149471 DT.115492 DT.95149458 DT.100790420 DT.121209927 DT.40220836 DT.92471369 DT.75176378 24/583 AceView cDNA sequences (see all 583): W94376 BU500844 T11171 CD365075 BM545641 AA992533 BQ719379 AI471209 CA428733 BI966037 AI420202 AW963484 AB035173 BI260659 AA401021 BP362196 AJ507293 BQ072504 AU102582 BQ129959 BM547386 CR592171 BM674642 F29391
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for AK1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for AK1
|
Expression
for AK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACAGCTGAG
About this image
See AK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AK1
SOURCE GeneReport for Unigene cluster: Hs.175473
SABiosciences Custom PCR Arrays for AK1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AK1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AK1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AK1 |
Orthologs
for AK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for AK1 gene from 6/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
AK11 |
adenylate kinase 1 |
78.71(n)
84.29(a) |
|
396002 NM_205109.1 NP_990440.1 |
lizard
(Anolis carolinensis) |
Reptilia |
AK16 |
-- |
86(a) |
1 ↔ 1 |
AAWZ02036994(7723-14274) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BQ733375.12 |
-- |
73.34(n) |
|
BQ733375.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.142832 |
Transcribed sequence with moderate similarity to protein more |
75.41(n) |
|
CF998824.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Adk11 , 3 |
adenylate kinase3
Adenylate kinase-11 |
48(a)3
56.32(n)1
50.53(a)1 |
|
69A23
393961 NM_168493.11 NP_729792.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
F38B2.41 , 3 |
adenylate kinase3
Protein F38B2.41 |
59(a)3
57.88(n)1
59.89(a)1 |
|
X(11321946-11322944)3
1813171 NM_077483.41 NP_509884.11 |
ENSEMBL Gene Tree for AK1 (if available)
TreeFam Gene Tree for AK1 (if available) |
Paralogs
for AK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AK1 gene
- AK52 LOC3908772 CMPK12
4 SIMAP similar genes for AK1 using alignment to 6 protein entries: KAD1_HUMAN (see all proteins):AK5 CMPK CMPK1 AK2
AK1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for AK1
PGOHUM00000234471
|
Genomic Variants
for AK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: KAD1_HUMAN, P00568Polymorphism: This enzyme represents the most common of at least five alleles
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AK1 (130628759 - 130640022 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for AK1
2 CNVs: 52728 65523
2 Indels: 65524 52727
Human Gene Mutation Database (HGMD): AK1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AK1 |
|
Disorders
/ Diseases
for AK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AK1 for disorders About GeneDecksing
OMIM gene information: 103000
OMIM disorders: 612631
UniProtKB/Swiss-Prot: KAD1_HUMAN, P00568
Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency (HAAKD) [MIM:612631]
18  diseases for AK1: About MalaCardshemolytic anemia hemolytic anemia due to adenylate kinase deficiency dystonia musculorum deformans nail-patella syndrome
anemia reticular dysgenesis familial dystonia morbid obesity
tuberous sclerosis noma obesity cervical cancer
cervicitis retinoblastoma ischemia hypertension
schizophrenia immunodeficiency
3 diseases from the University of Copenhagen DISEASES database for AK1:nail-patella syndrome Dystonia musculorum deformans Familial dystonia 1 Novoseek disease relationship for AK1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
1 |
15717328 (1) |
Genatlas disease: AK1 hemolytic anemia
Genetic Association Database (GAD): AK1
Human Genome Epidemiology (HuGE) Navigator: AK1 (1 document)
Export disorders for AK1 gene to outside databases
|
Publications
for AK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AK1 gene, integrated from 9 sources (see all 95):
(articles sorted by number of sources associating them with AK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Red cell adenylate kinase deficiency: molecular study of 3 new mutations (118G>A, 190G>A, and GAC deletion) associated with hereditary nonspherocytic hemolytic anemia. (PubMed id 12649162)1, 2 Corrons J.-L....Beutler E. (2003)
- A case of complete adenylate kinase deficiency due to a nonsense mutation in AK-1 gene (Arg 107 --> Stop, CGA --> TGA) associated with chronic haemolytic anaemia. (PubMed id 10233365)1, 4 Bianchi P....Zanella A. (1999)
- Severe erythrocyte adenylate kinase deficiency due to homozygous A-->G substitution at codon 164 of human AK1 gene associated with chronic haemolytic anaemia. (PubMed id 9432020)2, 4 Qualtieri A.... Brancati C. (1997)
- Human adenylate kinase deficiency associated with hemolytic anemia. A single base substitution affecting solubility and catalytic activity of the cytosolic adenylate kinase. (PubMed id 2542324)1, 2 Matsuura S.... Nakazawa A. (1989)
- Primary and tertiary structure of the principal human adenylate kinase. (PubMed id 183954)1, 2 von Zabern I....Pai E.F. (1976)
- wt p53 dependent expression of a membrane-associated isoform of adenylate kinase. (PubMed id 10557075)1, 9 Collavin L....Schneider C. (1999)
- Cloning and expression of human adenylate kinase 2 isozymes: differential expression of adenylate kinase 1 and 2 in human muscle tissues. (PubMed id 9504408)1, 9 Lee Y.... Choe I.S. (1998)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Neuropathogenic role of adenylate kinase-1 in Ab-media ted tau phosphorylation via AMPK and GSK3b. (PubMed id 22419736)1 Park H....Jung Y.K. (2012)
|
External Searches for AK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AK1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AK1 | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/Adenylate_kinase |
|
| | |
About This Section
| Patent Information for AK1 gene:
Search GeneIP for patents involving AK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for AK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for AK1 | | OriGene shRNA RFP for AK1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AK1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AK1 | | | OriGene Protein Over-expression Lysate for AK1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AK1 | | OriGene 3'-UTR Clone for AK1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AK1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AK1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for AK1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for AK1 | | OriGene Custom Protein Services for AK1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AK1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AK1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AK1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AK1 |
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| | | | Search Tocris compounds for AK1 |
| |  |  |  |  | | | | | | Recombinant Protein for AK1 |
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 | | | AK1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AK1 |
|  |  |  | | | | ThermoFisher Antibodies for AK1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AK1 |
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