Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AJUBA Gene

protein-coding   GIFtS: 49
GCID: GC14M023441

Ajuba LIM Protein

(Previous names: jub, ajuba homolog (Xenopus laevis))
(Previous symbol: JUB)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ajuba LIM Protein1 2
JUB1 2 3
Jub, Ajuba Homolog (Xenopus Laevis)1
Jub, Ajuba Homolog2
LIM Domain-Containing Protein Ajuba2
Protein Ajuba2

External Ids:    HGNC: 202501   Entrez Gene: 849622   Ensembl: ENSG000001294747   OMIM: 6090665   UniProtKB: Q96IF13   

Export aliases for AJUBA gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AJUBA Gene: 
AJUBA (ajuba LIM protein) is a protein-coding gene. Diseases associated with AJUBA include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. GO annotations related to this gene include chromatin binding and actin filament binding. An important paralog of this gene is LPP.

UniProtKB/Swiss-Prot: AJUBA_HUMAN, Q96IF1
Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is
involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of
gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes
to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the
actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an
important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1
signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the
PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of
GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of
E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases
and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing.
Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1

Gene Wiki entry for AJUBA (JUB) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for AJUBA
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAJUBA promoter sequence
   Search SABiosciences Chromatin IP Primers for AJUBA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AJUBA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

AJUBA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AJUBA gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M023441:  view genomic region     (about GC identifiers)

Start:
23,440,383 bp from pter      End:
23,451,851 bp from pter
Size:
11,469 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AJUBA_HUMAN, Q96IF1 (See protein sequence)
Recommended Name: LIM domain-containing protein ajuba  
Size: 538 amino acids; 56934 Da
Subunit: Interacts with GRB2, PIP5K1B and SLC1A2 (By similarity). Interacts with AURKA; the interaction occurs
during mitosis and both proteins are phosphorylated as they form a complex. Interacts with CTNNA1 and with
F-actin. Interacts with LATS2; the interaction occurs during mitosis and the complex regulates organization of
the spindle apparatus through recruitment of TUBG to the centrosome. Forms a complex with SQSTM1, PRKCZ and
TRAF6. Component of the GFI1-AJUBA-HDAC1 repressor complex. Interacts directly (via the LIM domains) with GFI1;
the interaction results in the HDAC-dependent corepression of a subset of GFI1 target genes, and is independent
of the GFI1 SNAG domain. Interacts with HDAC1, HDAC2 and HDAC3. Interacts with SNAI2/SLUG (via SNAG domain) and
SCRT1 (via SNAG domain) (By similarity). Interacts with EIF4E, AGO1, AGO2, DCP2, DDX6, LATS1, LATS2, SAV1,
EGLN2/PHD1 and EGLN3/PHD3. Interacts (via LIM domains) with isoform 1 and isoform 3 of VHL. Interacts (via LIM
domains) with SNAI1 (via SNAG domain)
Subcellular location: Cytoplasm, cytoskeleton. Cell membrane. Cell junction. Nucleus. Cytoplasm, cytoskeleton,
microtubule organizing center, centrosome. Cytoplasm, P-body. Note=Shuttles between the cytoplasm and the
nucleus. Localizes on centrosomes during G2-M phase. Preferentially co- localizes with cadherin-adhesive
complexes at sites of cell-cell contacts. Colocalizes with GFI1 in the nucleus
Miscellaneous: 'Ajuba' means 'curiosity' in Urdu, an Indian dialect
Secondary accessions: A8MX18 D3DS37
Alternative splicing: 2 isoforms:  Q96IF1-1   Q96IF1-2   

Explore the universe of human proteins at neXtProt for AJUBA: NX_Q96IF1

Explore proteomics data for AJUBA at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by LATS2 during mitosis. Phosphorylated by AURKA
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96IF1

  • AJUBA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AJUBA Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_116265.1  NP_932352.1  

    ENSEMBL proteins: 
     ENSP00000262713   ENSP00000380543   ENSP00000452369   ENSP00000451649   ENSP00000452325  
     ENSP00000451772   ENSP00000354491  

    Human Recombinant Protein Products for AJUBA: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for AJUBA
    OriGene Protein Over-expression Lysate for AJUBA
    OriGene MassSpec for AJUBA 
    OriGene Custom Protein Services for AJUBA
    GenScript Custom Purified and Recombinant Proteins Services for AJUBA
    Novus Biologicals AJUBA Protein
    Novus Biologicals AJUBA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA--
    GO:0005634nucleus IDA18805794
    GO:0005667transcription factor complex IEA--
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol IEA--

    AJUBA for ontologies           About GeneDecksing



    AJUBA Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for AJUBA
    Cell Signaling Technology (CST) Antibodies for AJUBA  (JUB)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for AJUBA
    GenScript Custom Superior Antibodies Services for AJUBA
    Novus Biologicals AJUBA Antibodies
    Abcam antibodies for AJUBA
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for AJUBA
    LSBio Antibodies in human, mouse, rat for AJUBA 

    Assay Products for AJUBA: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AJUBA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AJUBA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q96IF1

    ProtoNet protein and cluster: Q96IF1

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: AJUBA_HUMAN, Q96IF1
    Domain: LIM region interacts with CTNNA1. The preLIM region binds directly actin filaments
    Domain: LIM-2 and LIM-3 domains mediate the interaction with the N-terminal region of AURKA. The association
    between LATS2 and AJUBA required the second LIM domain of AJUBA
    Similarity: Belongs to the zyxin/ajuba family
    Similarity: Contains 3 LIM zinc-binding domains


    AJUBA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AJUBA_HUMAN, Q96IF1
    Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is
    involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of
    gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes
    to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the
    actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an
    important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1
    signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the
    PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of
    GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of
    E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases
    and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing.
    Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003714transcription corepressor activity IDA18805794
    GO:0005515protein binding IPI15778465
    GO:0008270zinc ion binding IEA--
    GO:0045294alpha-catenin binding IDA12417594
         
    AJUBA for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ajuba):
     cellular 

    AJUBA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ajubatm1Gdl for AJUBA

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AJUBA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AJUBA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AJUBA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AJUBA 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AJUBA
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AJUBA
    SwitchGear 3'UTR luciferase reporter plasmidAJUBA 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AJUBA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AJUBA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AJUBA
    Sirion Biotech Customized adenovirus for overexpression of AJUBA

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for AJUBA (see all 12)
    OriGene ORF clones in mouse, rat for AJUBA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for AJUBA
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AJUBA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AJUBA
    Sirion Biotech Customized lentivirus for stable overexpression of AJUBA 
                         Customized lentivirus expression plasmids for stable overexpression of AJUBA 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AJUBA
    Search LifeMap BioReagents cell lines for AJUBA
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AJUBA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AJUBA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Hippo signaling pathway
    Hippo signaling pathway
    2Cytoskeletal Signaling
    Cytoskeletal Signaling
    3Aurora A signaling
    Aurora A signaling
    4Adhesion
    Adhesion
    5E-cadherin signaling in keratinocytes
    E-cadherin signaling in keratinocytes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for AJUBA
        Cytoskeletal Signaling
    Adhesion

    2 BioSystems Pathways for AJUBA
        E-cadherin signaling in keratinocytes
    Aurora A signaling


    1         Kegg Pathway  (Kegg details for AJUBA):
        Hippo signaling pathway


    AJUBA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AJUBA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/25 Interacting proteins for AJUBA (Q96IF12, 3 ENSP000002627134) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2877712 I2D: score=3 STRING: ENSP00000344782
    SFNP319472, 3MINT-3975697 MINT-3976673 I2D: score=2 
    LATS2Q9NRM72, 3, ENSP000003720354MINT-1772128 MINT-1778030 MINT-1772055 MINT-1790017 MINT-1771993 MINT-1772097 I2D: score=2 STRING: ENSP00000372035
    AURKAIP1Q9NWT83, ENSP000003197784I2D: score=1 STRING: ENSP00000319778
    CTNNA1P352213, ENSP000003046694I2D: score=1 STRING: ENSP00000304669
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001666response to hypoxia IDA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007049cell cycle IEA--
    GO:0016339calcium-dependent cell-cell adhesion IEA--

    AJUBA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AJUBA

    Search CenterWatch for drugs/clinical trials and news about AJUBA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AJUBA gene (2 alternative transcripts): 
    NM_032876.4  NM_198086.1  

    Unigene Cluster for AJUBA:

    Ajuba LIM protein
    Hs.655832  [show with all ESTs]
    Unigene Representative Sequence: NM_032876
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262713(uc001why.3 uc001whz.3) ENST00000397388 ENST00000553592
    ENST00000556731 ENST00000553911 ENST00000555479 ENST00000553736 ENST00000361265

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AJUBA
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AJUBA
    SwitchGear 3'UTR luciferase reporter plasmidAJUBA 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AJUBA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AJUBA
    Clone
    Products:
         
    OriGene clones in human, mouse for AJUBA (see all 12)
    OriGene ORF clones in mouse, rat for AJUBA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for AJUBA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AJUBA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AJUBA
    Sirion Biotech Customized lentivirus for stable overexpression of AJUBA 
                         Customized lentivirus expression plasmids for stable overexpression of AJUBA 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AJUBA
    OriGene qSTAR qPCR primer pairs in human, mouse for AJUBA
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat AJUBA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AJUBA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AJUBA

    Additional mRNA sequence: 

    AK025567.1 AK096128.1 AY169959.1 BC007580.1 BC016733.1 BC034968.2 

    10 DOTS entries:

    DT.100775739  DT.455766  DT.120777830  DT.92426492  DT.102836338  DT.100775734  DT.100737442  DT.40129291 
    DT.120777678  DT.100775735 

    24/146 AceView cDNA sequences (see all 146):

    CA442366 BQ439546 AI918246 BQ958701 NM_198086 BC007580 NM_032876 BM680549 
    BU149830 BI260853 BU543883 CB135297 AY169959 D12422 BM718100 BM479543 
    CN482905 BQ232031 BU163376 BM800674 CB106031 BU678010 AK096128 CB143855 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AJUBA expression in normal human tissues (normalized intensities)      AJUBA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTGGATAT
    AJUBA Expression
    About this image


    AJUBA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Uterus (Reproductive System)
             endometrial endothelial cell   
     
     Skeletal Muscle (Muscoskeletal System)
             tongue squamous cells   
     
     Eye (Sensory Organs)
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Oral Cavity (Muscoskeletal System)
             tongue squamous cells   

    See AJUBA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AJUBA

    SOURCE GeneReport for Unigene cluster: Hs.655832
        SABiosciences Custom PCR Arrays for AJUBA
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AJUBA
    OriGene qSTAR qPCR primer pairs in human, mouse for AJUBA
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat AJUBA
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AJUBA
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AJUBA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AJUBA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for AJUBA gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ajuba5
    Jub1
    ajuba1, 5 88.27(n)1
    93.67(a)1
      14 (27.84 cM)5
    164751  NM_010590.51  NP_034720.21 
     545674695 
    zebrafish
    (Danio rerio)
    Actinopterygii ajuba1 ajuba LIM protein 56.34(n)
    53.85(a)
      572549  XM_696274.5  XP_701366.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta jub6
    Ajuba LIM protein
    23(a)
    1 → many
    X(13720363-13724347)


    ENSEMBL Gene Tree for AJUBA (if available)
    TreeFam Gene Tree for AJUBA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AJUBA gene
    LPP2  TRIP62  FBLIM12  WTIP2  ZYX2  LIMD12  
    8 SIMAP similar genes for AJUBA using alignment to 4 protein entries:     AJUBA_HUMAN (see all proteins):
    WTIP    CSRP1    DKFZp686P2249    LIMD1    FHL2    LIMS2
    ABLIM1    PDLIM5

    AJUBA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/260 SNPs in AJUBA are shown (see all 260)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1849698691,2
    --23439954(+) AACCCA/GGGAGA 2 -- ds50010--------
    rs1115392601,2
    C,F--23439961(+) GAGACG/TGAGGT 2 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1890346011,2
    --23440038(+) AAAAAA/CCCTGA 2 -- ds50010--------
    rs598410881,2
    C--23440049(+) GAGCCG/AGGCAC 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs118443621,2
    H--23440080(+) ccagcA/Cctttg 2 -- ds50010--------
    rs346153461,2
    C,F--23440281(+) GATAGC/TGCCAC 2 -- ds50013Minor allele frequency- T:0.33NA 6
    rs21808341,2
    C,F,H--23440404(+) TCATAG/AGGCCT 2 -- ds500125Minor allele frequency- A:0.18NA NS EA WA 2902
    rs121470251,2
    C,F,H--23440742(+) AAACCA/GATTAG 2 -- ut3117Minor allele frequency- G:0.11NS EA NA 2224
    rs1389763251,2
    --23441018(+) ATACAA/CAAAAT 2 -- ut310--------
    rs1428779271,2
    --23441041(+) TGTATC/TTATTG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for AJUBA (23440383 - 23451851 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AJUBA: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AJUBA
    DNA2.0 Custom Variant and Variant Library Synthesis for AJUBA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609066    OMIM disorders: --

    4 diseases for AJUBA:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    hypoxia    breast cancer


    AJUBA for disorders           About GeneDecksing


    Export disorders for AJUBA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AJUBA gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with AJUBA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. (PubMed id 22286099)1, 2 Foxler D.E.... Sharp T.V. (2012)
    2. Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. (PubMed id 18331720)1, 2 Langer E.M....Longmore G.D. (2008)
    3. Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor. (PubMed id 18805794)1, 2 Montoya-Durango D.E....Grimes H.L. (2008)
    4. LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. (PubMed id 16413547)1, 2 Abe Y.... Yamamoto T. (2006)
    5. The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex. (PubMed id 15870274)1, 2 Feng Y. and Longmore G.D. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. (PubMed id 12417594)1, 2 Marie H.... Braga V.M. (2003)
    8. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. (PubMed id 13678582)1, 2 Hirota T.... Saya H. (2003)
    9. Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. (PubMed id 10330178)1, 3 Goyal R.K....Longmore G.D. (1999)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84962 HGNC: 20250 AceView: JUB Ensembl:ENSG00000129474 euGenes: HUgn84962
    ECgene: AJUBA Kegg: 84962 H-InvDB: AJUBA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AJUBA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AJUBA gene:
    Search GeneIP for patents involving AJUBA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for AJUBA (Ajuba)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for AJUBA  
     OriGene qPCR primer pairs and template standards for AJUBA   OriGene Protein Over-expression Lysate for AJUBA  
     OriGene MassSpec something-or-other for AJUBA   OriGene clones in human, mouse for AJUBA  
     OriGene qSTAR qPCR primer pairs in human, mouse for AJUBA   OriGene Purified Protein for AJUBA  
     OriGene ORF clones in mouse, rat for AJUBA   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AJUBA   OriGene Custom Protein Services for AJUBA  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AJUBA
     QIAGEN SeqTarget long-range PCR primers for resequencing AJUBA
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AJUBA
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AJUBA
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AJUBA
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AJUBA
     GenScript Custom Purified and Recombinant Proteins Services for AJUBA GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for AJUBA
     GenScript Custom Assay Services for AJUBA GenScript Custom Superior Antibodies Services for AJUBA
     GenScript Custom overexpressing Cell Line Services for AJUBA CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for AJUBA  (JUB)

     Search Regulatory tfbs for AJUBA
     Search Chromatin IP Primers for AJUBA
     Search RT2 qPCR Primer Assays in human, mouse, rat AJUBA
     Search GNC Networks for AJUBA
     SABiosciences Custom PCR Arrays for AJUBA
     Search Tocris compounds for AJUBA
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     AJUBA antibodies
     AJUBA proteins
     AJUBA lysates
     Antibodies for AJUBA
     See all of Abcam's Antibodies, Kits and Proteins for AJUBA
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for AJUBA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AJUBA
     SwitchGear 3'UTR luciferase reporter plasmids for AJUBA
     SwitchGear Promoter luciferase reporter plasmids for AJUBA
     Search ThermoFisher Antibodies for AJUBA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AJUBA
     inGenious Targeting Laboratory - Custom generated mouse model solutions for AJUBA
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AJUBA
    Customized:
     lentivirus for stable overexpression of AJUBA
     lentivirus expression plasmids for stable overexpression of AJUBA
     adenovirus for overexpression of AJUBA
     LSBio Antibodies in human, mouse, rat for AJUBA
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AJUBA gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4