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Aliases for AJUBA Gene

Aliases for AJUBA Gene

  • Ajuba LIM Protein 2 3
  • JUB 3 4
  • Jub, Ajuba Homolog (Xenopus Laevis) 2
  • LIM Domain-Containing Protein Ajuba 3
  • Jub, Ajuba Homolog 3

External Ids for AJUBA Gene

Previous Symbols for AJUBA Gene

  • JUB

Summaries for AJUBA Gene

GeneCards Summary for AJUBA Gene

AJUBA (Ajuba LIM Protein) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include chromatin binding and actin filament binding. An important paralog of this gene is ABLIM3.

UniProtKB/Swiss-Prot for AJUBA Gene

  • Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.

Gene Wiki entry for AJUBA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AJUBA Gene

Genomics for AJUBA Gene

Genomic Location for AJUBA Gene

Start:
22,971,174 bp from pter
End:
22,982,642 bp from pter
Size:
11,469 bases
Orientation:
Minus strand

Genomic View for AJUBA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AJUBA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AJUBA Gene

No data available for Regulatory Elements for AJUBA Gene

Proteins for AJUBA Gene

  • Protein details for AJUBA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IF1-AJUBA_HUMAN
    Recommended name:
    LIM domain-containing protein ajuba
    Protein Accession:
    Q96IF1
    Secondary Accessions:
    • A8MX18
    • D3DS37

    Protein attributes for AJUBA Gene

    Size:
    538 amino acids
    Molecular mass:
    56934 Da
    Quaternary structure:
    • Interacts with GRB2, PIP5K1B and SLC1A2 (By similarity). Interacts with AURKA; the interaction occurs during mitosis and both proteins are phosphorylated as they form a complex. Interacts with CTNNA1 and with F-actin. Interacts with LATS2; the interaction occurs during mitosis and the complex regulates organization of the spindle apparatus through recruitment of TUBG to the centrosome. Forms a complex with SQSTM1, PRKCZ and TRAF6. Component of the GFI1-AJUBA-HDAC1 repressor complex. Interacts directly (via the LIM domains) with GFI1; the interaction results in the HDAC-dependent corepression of a subset of GFI1 target genes, and is independent of the GFI1 SNAG domain. Interacts with HDAC1, HDAC2 and HDAC3. Interacts with SNAI2/SLUG (via SNAG domain) and SCRT1 (via SNAG domain) (By similarity). Interacts with EIF4E, AGO1, AGO2, DCP2, DDX6, LATS1, LATS2, SAV1, EGLN2/PHD1 and EGLN3/PHD3. Interacts (via LIM domains) with isoform 1 and isoform 3 of VHL. Interacts (via LIM domains) with SNAI1 (via SNAG domain).
    Miscellaneous:
    • Ajuba means curiosity in Urdu, an Indian dialect

    Alternative splice isoforms for AJUBA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AJUBA Gene

Proteomics data for AJUBA Gene at MOPED

Post-translational modifications for AJUBA Gene

  • Phosphorylated by LATS2 during mitosis. Phosphorylated by AURKA
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AJUBA Gene

No data available for DME Specific Peptides for AJUBA Gene

Domains for AJUBA Gene

Protein Domains for AJUBA Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96IF1

UniProtKB/Swiss-Prot:

AJUBA_HUMAN
Domain:
  • LIM region interacts with CTNNA1. The preLIM region binds directly actin filaments:
    • Q96IF1
  • LIM-2 and LIM-3 domains mediate the interaction with the N-terminal region of AURKA. The association between LATS2 and AJUBA required the second LIM domain of AJUBA:
    • Q96IF1
  • Contains 3 LIM zinc-binding domains.:
    • Q96IF1
Family:
  • Belongs to the zyxin/ajuba family.:
    • Q96IF1
genes like me logo Genes that share domains with AJUBA: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for AJUBA Gene

Function for AJUBA Gene

Molecular function for AJUBA Gene

UniProtKB/Swiss-Prot Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.

Gene Ontology (GO) - Molecular Function for AJUBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003714 transcription corepressor activity IDA 18805794
GO:0005515 protein binding IPI 15778465
GO:0008270 zinc ion binding IEA --
GO:0045294 alpha-catenin binding IDA 12417594
genes like me logo Genes that share ontologies with AJUBA: view

Phenotypes for AJUBA Gene

MGI mutant phenotypes for AJUBA:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with AJUBA: view

Animal Models for AJUBA Gene

MGI Knock Outs for AJUBA:

miRNA for AJUBA Gene

miRTarBase miRNAs that target AJUBA

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AJUBA Gene

Localization for AJUBA Gene

Subcellular locations from UniProtKB/Swiss-Prot for AJUBA Gene

Cytoplasm, cytoskeleton. Cell membrane. Cell junction. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, P-body. Note=Shuttles between the cytoplasm and the nucleus. Localizes on centrosomes during G2-M phase. Preferentially co- localizes with cadherin-adhesive complexes at sites of cell-cell contacts. Colocalizes with GFI1 in the nucleus.

Gene Ontology (GO) - Cellular Components for AJUBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IDA 20616046
GO:0005634 nucleus IDA 18805794
GO:0005667 transcription factor complex IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with AJUBA: view

No data available for Subcellular locations from COMPARTMENTS for AJUBA Gene

Pathways for AJUBA Gene

genes like me logo Genes that share pathways with AJUBA: view

Pathways by source for AJUBA Gene

2 Cell Signaling Technology pathways for AJUBA Gene
2 BioSystems pathways for AJUBA Gene

Gene Ontology (GO) - Biological Process for AJUBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0000278 mitotic cell cycle TAS --
GO:0001666 response to hypoxia IDA 22286099
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with AJUBA: view

Transcripts for AJUBA Gene

Unigene Clusters for AJUBA Gene

Ajuba LIM protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AJUBA Gene

No ASD Table

Relevant External Links for AJUBA Gene

GeneLoc Exon Structure for
AJUBA
ECgene alternative splicing isoforms for
AJUBA

Expression for AJUBA Gene

mRNA expression in normal human tissues for AJUBA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AJUBA Gene

This gene is overexpressed in Liver (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AJUBA Gene

SOURCE GeneReport for Unigene cluster for AJUBA Gene Hs.655832

genes like me logo Genes that share expressions with AJUBA: view

No data available for mRNA Expression by UniProt/SwissProt for AJUBA Gene

Orthologs for AJUBA Gene

This gene was present in the common ancestor of animals.

Orthologs for AJUBA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AJUBA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AJUBA 35
  • 91.64 (n)
  • 95.91 (a)
AJUBA 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AJUBA 35
  • 91.95 (n)
  • 96.78 (a)
AJUBA 36
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ajuba 35
  • 88.27 (n)
  • 93.67 (a)
Ajuba 16
Ajuba 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AJUBA 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ajuba 35
  • 88.17 (n)
  • 93.12 (a)
zebrafish
(Danio rerio)
Actinopterygii ajuba 36
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta jub 36
  • 25 (a)
OneToMany
Species with no ortholog for AJUBA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AJUBA Gene

ENSEMBL:
Gene Tree for AJUBA (if available)
TreeFam:
Gene Tree for AJUBA (if available)

Paralogs for AJUBA Gene

Paralogs for AJUBA Gene

Selected SIMAP similar genes for AJUBA Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AJUBA: view

Variants for AJUBA Gene

Sequence variations from dbSNP and Humsavar for AJUBA Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1923 -- 22,971,970(+) TAATA(A/G)CTCAG utr-variant-3-prime
rs941720 -- 22,974,673(+) CGGAT(A/G)TTAGG intron-variant
rs941721 -- 22,974,753(+) ACTTC(C/T)GGCAG intron-variant
rs941722 -- 22,978,929(+) ACGAG(A/C)TGTTC utr-variant-3-prime, intron-variant, upstream-variant-2KB
rs941723 -- 22,979,322(+) CGGGC(C/T)TGCCC intron-variant

Relevant External Links for AJUBA Gene

HapMap Linkage Disequilibrium report
AJUBA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AJUBA Gene

Disorders for AJUBA Gene

No disorders were found for AJUBA Gene.

No data available for UniProtKB/Swiss-Prot for AJUBA Gene

Publications for AJUBA Gene

  1. Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. (PMID: 10330178) Goyal R.K. … Longmore G.D. (Mol. Cell. Biol. 1999) 2 3
  2. The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. (PMID: 12417594) Marie H. … Braga V.M. (J. Biol. Chem. 2003) 3 4
  3. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. (PMID: 13678582) Hirota T. … Saya H. (Cell 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex. (PMID: 15870274) Feng Y. … Longmore G.D. (Mol. Cell. Biol. 2005) 3 4

Products for AJUBA Gene

Sources for AJUBA Gene

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