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Aliases for AJUBA Gene

Aliases for AJUBA Gene

  • Ajuba LIM Protein 2 3 5
  • JUB 3 4
  • Jub, Ajuba Homolog (Xenopus Laevis) 2
  • Jub, Ajuba Homolog 3

External Ids for AJUBA Gene

Previous HGNC Symbols for AJUBA Gene

  • JUB

Previous GeneCards Identifiers for AJUBA Gene

  • GC14M023441

Summaries for AJUBA Gene

GeneCards Summary for AJUBA Gene

AJUBA (Ajuba LIM Protein) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Developmental Biology. GO annotations related to this gene include chromatin binding and actin filament binding. An important paralog of this gene is ABLIM3.

UniProtKB/Swiss-Prot for AJUBA Gene

  • Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.

Gene Wiki entry for AJUBA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AJUBA Gene

Genomics for AJUBA Gene

Regulatory Elements for AJUBA Gene

Promoters for AJUBA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AJUBA on UCSC Golden Path with GeneCards custom track

Genomic Location for AJUBA Gene

Chromosome:
14
Start:
22,971,174 bp from pter
End:
22,982,642 bp from pter
Size:
11,469 bases
Orientation:
Minus strand

Genomic View for AJUBA Gene

Genes around AJUBA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AJUBA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AJUBA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AJUBA Gene

Proteins for AJUBA Gene

  • Protein details for AJUBA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IF1-AJUBA_HUMAN
    Recommended name:
    LIM domain-containing protein ajuba
    Protein Accession:
    Q96IF1
    Secondary Accessions:
    • A8MX18
    • D3DS37

    Protein attributes for AJUBA Gene

    Size:
    538 amino acids
    Molecular mass:
    56934 Da
    Quaternary structure:
    • Interacts with GRB2, PIP5K1B and SLC1A2 (By similarity). Interacts with AURKA; the interaction occurs during mitosis and both proteins are phosphorylated as they form a complex. Interacts with CTNNA1 and with F-actin. Interacts with LATS2; the interaction occurs during mitosis and the complex regulates organization of the spindle apparatus through recruitment of TUBG to the centrosome. Forms a complex with SQSTM1, PRKCZ and TRAF6. Component of the GFI1-AJUBA-HDAC1 repressor complex. Interacts directly (via the LIM domains) with GFI1; the interaction results in the HDAC-dependent corepression of a subset of GFI1 target genes, and is independent of the GFI1 SNAG domain. Interacts with HDAC1, HDAC2 and HDAC3. Interacts with SNAI2/SLUG (via SNAG domain) and SCRT1 (via SNAG domain) (By similarity). Interacts with EIF4E, AGO1, AGO2, DCP2, DDX6, LATS1, LATS2, SAV1, EGLN2/PHD1 and EGLN3/PHD3. Interacts (via LIM domains) with isoform 1 and isoform 3 of VHL. Interacts (via LIM domains) with SNAI1 (via SNAG domain).
    Miscellaneous:
    • Ajuba means curiosity in Urdu, an Indian dialect.

    Alternative splice isoforms for AJUBA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AJUBA Gene

Proteomics data for AJUBA Gene at MOPED

Post-translational modifications for AJUBA Gene

  • Phosphorylated by LATS2 during mitosis. Phosphorylated by AURKA.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for AJUBA (JUB)

No data available for DME Specific Peptides for AJUBA Gene

Domains & Families for AJUBA Gene

Gene Families for AJUBA Gene

Protein Domains for AJUBA Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96IF1

UniProtKB/Swiss-Prot:

AJUBA_HUMAN :
  • LIM region interacts with CTNNA1. The preLIM region binds directly actin filaments.
  • Belongs to the zyxin/ajuba family.
Domain:
  • LIM region interacts with CTNNA1. The preLIM region binds directly actin filaments.
  • LIM-2 and LIM-3 domains mediate the interaction with the N-terminal region of AURKA. The association between LATS2 and AJUBA required the second LIM domain of AJUBA.
  • Contains 3 LIM zinc-binding domains.
Family:
  • Belongs to the zyxin/ajuba family.
genes like me logo Genes that share domains with AJUBA: view

Function for AJUBA Gene

Molecular function for AJUBA Gene

UniProtKB/Swiss-Prot Function:
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.

Gene Ontology (GO) - Molecular Function for AJUBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with AJUBA: view
genes like me logo Genes that share phenotypes with AJUBA: view

Animal Models for AJUBA Gene

MGI Knock Outs for AJUBA:

Animal Model Products

miRNA for AJUBA Gene

miRTarBase miRNAs that target AJUBA

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AJUBA Gene

Localization for AJUBA Gene

Subcellular locations from UniProtKB/Swiss-Prot for AJUBA Gene

Cytoplasm, cytoskeleton. Cell membrane. Cell junction. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, P-body. Note=Shuttles between the cytoplasm and the nucleus. Localizes on centrosomes during G2-M phase. Preferentially co- localizes with cadherin-adhesive complexes at sites of cell-cell contacts. Colocalizes with GFI1 in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AJUBA Gene COMPARTMENTS Subcellular localization image for AJUBA gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
plasma membrane 5
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for AJUBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with AJUBA: view

Pathways & Interactions for AJUBA Gene

genes like me logo Genes that share pathways with AJUBA: view

Pathways by source for AJUBA Gene

Gene Ontology (GO) - Biological Process for AJUBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0001666 response to hypoxia IDA 22286099
GO:0006351 transcription, DNA-templated IEA --
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
GO:0030032 lamellipodium assembly IEA --
genes like me logo Genes that share ontologies with AJUBA: view

No data available for SIGNOR curated interactions for AJUBA Gene

Drugs & Compounds for AJUBA Gene

No Compound Related Data Available

Transcripts for AJUBA Gene

Unigene Clusters for AJUBA Gene

Ajuba LIM protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AJUBA Gene

No ASD Table

Relevant External Links for AJUBA Gene

GeneLoc Exon Structure for
AJUBA
ECgene alternative splicing isoforms for
AJUBA

Expression for AJUBA Gene

mRNA expression in normal human tissues for AJUBA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AJUBA Gene

This gene is overexpressed in Liver (x4.2).

Protein differential expression in normal tissues from HIPED for AJUBA Gene

This gene is overexpressed in Heart (26.4), Fetal Liver (22.7), Placenta (10.6), and Fetal heart (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AJUBA Gene



SOURCE GeneReport for Unigene cluster for AJUBA Gene Hs.655832

genes like me logo Genes that share expression patterns with AJUBA: view

Protein tissue co-expression partners for AJUBA Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AJUBA Gene

Orthologs for AJUBA Gene

This gene was present in the common ancestor of animals.

Orthologs for AJUBA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AJUBA 35
  • 91.64 (n)
  • 95.91 (a)
AJUBA 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AJUBA 35
  • 91.95 (n)
  • 96.78 (a)
AJUBA 36
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ajuba 35
  • 88.27 (n)
  • 93.67 (a)
Ajuba 16
Ajuba 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ajuba 35
  • 88.17 (n)
  • 93.12 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia AJUBA 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AJUBA 36
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ajuba 36
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta jub 36
  • 25 (a)
OneToMany
Species with no ortholog for AJUBA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AJUBA Gene

ENSEMBL:
Gene Tree for AJUBA (if available)
TreeFam:
Gene Tree for AJUBA (if available)

Paralogs for AJUBA Gene

Paralogs for AJUBA Gene

(8) SIMAP similar genes for AJUBA Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AJUBA: view

Variants for AJUBA Gene

Sequence variations from dbSNP and Humsavar for AJUBA Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1923 -- 22,971,970(+) TAATA(A/G)CTCAG utr-variant-3-prime
rs1048652 -- 22,972,186(-) ATACT(A/G)GTCAG utr-variant-3-prime
rs1048654 -- 22,972,170(-) TTGAA(A/G)CTAGT utr-variant-3-prime
rs1048655 -- 22,972,167(-) AAACT(A/G)GTTCA utr-variant-3-prime
rs941720 -- 22,974,673(+) CGGAT(A/G)TTAGG intron-variant

Variation tolerance for AJUBA Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AJUBA Gene

HapMap Linkage Disequilibrium report
AJUBA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AJUBA Gene

Disorders for AJUBA Gene

Relevant External Links for AJUBA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AJUBA

No disorders were found for AJUBA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AJUBA Gene

Publications for AJUBA Gene

  1. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. (PMID: 22286099) Foxler D.E. … Sharp T.V. (Nat. Cell Biol. 2012) 3 4 67
  2. Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. (PMID: 10330178) Goyal R.K. … Longmore G.D. (Mol. Cell. Biol. 1999) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. LIM protein JUB promotes epithelial-mesenchymal transition in colorectal cancer. (PMID: 24673742) Liang X.H. … Zeng X.C. (Cancer Sci. 2014) 3
  5. A novel mechanism for activation of Aurora-A kinase by Ajuba. (PMID: 24680704) Bai M. … Yu L. (Gene 2014) 3

Products for AJUBA Gene

Sources for AJUBA Gene

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