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AJUBA Gene

protein-coding   GIFtS: 49
GCID: GC14M023441

Ajuba LIM Protein

(Previous names: jub, ajuba homolog (Xenopus laevis))
(Previous symbol: JUB)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ajuba LIM Protein1 2
JUB1 2 3
Jub, Ajuba Homolog (Xenopus Laevis)1
Jub, Ajuba Homolog2
LIM Domain-Containing Protein Ajuba2

External Ids:    HGNC: 202501   Entrez Gene: 849622   Ensembl: ENSG000001294747   OMIM: 6090665   UniProtKB: Q96IF13   

Export aliases for AJUBA gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AJUBA Gene:
AJUBA (ajuba LIM protein) is a protein-coding gene. GO annotations related to this gene include chromatin binding and actin filament binding. An important paralog of this gene is LPP.

UniProtKB/Swiss-Prot: AJUBA_HUMAN, Q96IF1
Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is
involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of
gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes
to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the
actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an
important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1
signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the
PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of
GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of
E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases
and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing.
Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1

Gene Wiki entry for AJUBA (JUB) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for AJUBA
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAJUBA promoter sequence
   Search Chromatin IP Primers for AJUBA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AJUBA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

AJUBA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AJUBA gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M023441:  view genomic region     (about GC identifiers)

Start:
23,440,383 bp from pter      End:
23,451,851 bp from pter
Size:
11,469 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AJUBA_HUMAN, Q96IF1 (See protein sequence)
Recommended Name: LIM domain-containing protein ajuba  
Size: 538 amino acids; 56934 Da
Subunit: Interacts with GRB2, PIP5K1B and SLC1A2 (By similarity). Interacts with AURKA; the interaction occurs
during mitosis and both proteins are phosphorylated as they form a complex. Interacts with CTNNA1 and with
F-actin. Interacts with LATS2; the interaction occurs during mitosis and the complex regulates organization of
the spindle apparatus through recruitment of TUBG to the centrosome. Forms a complex with SQSTM1, PRKCZ and
TRAF6. Component of the GFI1-AJUBA-HDAC1 repressor complex. Interacts directly (via the LIM domains) with GFI1;
the interaction results in the HDAC-dependent corepression of a subset of GFI1 target genes, and is independent
of the GFI1 SNAG domain. Interacts with HDAC1, HDAC2 and HDAC3. Interacts with SNAI2/SLUG (via SNAG domain) and
SCRT1 (via SNAG domain) (By similarity). Interacts with EIF4E, AGO1, AGO2, DCP2, DDX6, LATS1, LATS2, SAV1,
EGLN2/PHD1 and EGLN3/PHD3. Interacts (via LIM domains) with isoform 1 and isoform 3 of VHL. Interacts (via LIM
domains) with SNAI1 (via SNAG domain)
Miscellaneous: 'Ajuba' means 'curiosity' in Urdu, an Indian dialect
Secondary accessions: A8MX18 D3DS37
Alternative splicing: 2 isoforms:  Q96IF1-1   Q96IF1-2   

Explore the universe of human proteins at neXtProt for AJUBA: NX_Q96IF1

Explore proteomics data for AJUBA at MOPED

Post-translational modifications: 

  • Phosphorylated by LATS2 during mitosis. Phosphorylated by AURKA1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AJUBA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001276026.1  NP_116265.1  NP_932352.1  

    ENSEMBL proteins: 
     ENSP00000262713   ENSP00000380543   ENSP00000452369   ENSP00000451649   ENSP00000452325  
     ENSP00000451772   ENSP00000354491  
    Reactome Protein details: Q96IF1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q96IF1

    ProtoNet protein and cluster: Q96IF1

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: AJUBA_HUMAN, Q96IF1
    Domain: LIM region interacts with CTNNA1. The preLIM region binds directly actin filaments
    Domain: LIM-2 and LIM-3 domains mediate the interaction with the N-terminal region of AURKA. The association
    between LATS2 and AJUBA required the second LIM domain of AJUBA
    Similarity: Belongs to the zyxin/ajuba family
    Similarity: Contains 3 LIM zinc-binding domains


    Find genes that share domains with AJUBA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AJUBA_HUMAN, Q96IF1
    Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is
    involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of
    gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes
    to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the
    actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an
    important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1
    signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the
    PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of
    GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of
    E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases
    and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing.
    Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003714transcription corepressor activity IDA18805794
    GO:0005515protein binding IPI15778465
    GO:0008270zinc ion binding IEA--
    GO:0045294alpha-catenin binding IDA12417594
         
    Find genes that share ontologies with AJUBA           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ajuba):
     cellular 

    Find genes that share phenotypes with AJUBA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ajubatm1Gdl for AJUBA

       genOway: Develop your customized and physiologically relevant rodent model for AJUBA

    miRNA
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    miRTarBase miRNAs that target AJUBA:
    hsa-mir-10a-5p (MIRT025601), hsa-mir-196b-5p (MIRT042680), hsa-mir-128-3p (MIRT021880)

    Block miRNA regulation of human, mouse, rat AJUBA using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AJUBA_HUMAN, Q96IF1: Cytoplasm, cytoskeleton. Cell membrane. Cell junction. Nucleus. Cytoplasm, cytoskeleton,
    microtubule organizing center, centrosome. Cytoplasm, P-body. Note=Shuttles between the cytoplasm and the
    nucleus. Localizes on centrosomes during G2-M phase. Preferentially co- localizes with cadherin-adhesive
    complexes at sites of cell-cell contacts. Colocalizes with GFI1 in the nucleus

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA--
    GO:0005634nucleus IDA18805794
    GO:0005667transcription factor complex IEA--
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with AJUBA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AJUBA About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Regulation of PLK1 Activity at G2/M Transition0.77
    Mitotic G2-G2/M phases0.69
    G2/M Transition0.70
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    3Hippo signaling pathway
    Hippo signaling pathway
    4E-cadherin signaling in keratinocytes
    E-cadherin signaling in keratinocytes
    5Cytoskeletal Signaling
    Cytoskeletal Signaling


    Find genes that share SuperPaths with AJUBA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for AJUBA
        Cytoskeletal Signaling
    Adhesion

    2 BioSystems Pathways for AJUBA
        Aurora A signaling
    E-cadherin signaling in keratinocytes

    1 Reactome Pathway for AJUBA
        Regulation of PLK1 Activity at G2/M Transition


    1 Kegg Pathway  (Kegg details for AJUBA):
        Hippo signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AJUBA
    Interactions:

        Search GeneGlobe Interaction Network for AJUBA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AJUBA (Q96IF11, 2, 3 ENSP000002627134) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319471, 2, 3EBI-949782,EBI-476295 MINT-3975697 MINT-3976673 I2D: score=2 
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2877712 I2D: score=3 STRING: ENSP00000344782
    LATS2Q9NRM71, 2, 3, ENSP000003720354EBI-949782,EBI-3506895 MINT-1772128 MINT-1778030 MINT-1772055 MINT-1790017 MINT-1771993 MINT-1772097 I2D: score=2 STRING: ENSP00000372035
    AURKAIP1Q9NWT83, ENSP000003197784I2D: score=1 STRING: ENSP00000319778
    CTNNA1P352213, ENSP000003046694I2D: score=1 STRING: ENSP00000304669
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0000278mitotic cell cycle TAS--
    GO:0001666response to hypoxia IDA--
    GO:0006351transcription, DNA-templated IEA--

    Find genes that share ontologies with AJUBA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for AJUBA



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AJUBA gene (3 alternative transcripts): 
    NM_001289097.1  NM_032876.5  NM_198086.2  

    Unigene Cluster for AJUBA:

    Ajuba LIM protein
    Hs.655832  [show with all ESTs]
    Unigene Representative Sequence: NM_032876
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262713(uc001why.3 uc001whz.3) ENST00000397388 ENST00000553592
    ENST00000556731 ENST00000553911 ENST00000555479 ENST00000553736 ENST00000361265

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    Additional mRNA sequence: 

    AK025567.1 AK096128.1 AY169959.1 BC007580.1 BC016733.1 BC034968.2 

    10 DOTS entries:

    DT.100775739  DT.455766  DT.120777830  DT.92426492  DT.102836338  DT.100775734  DT.100737442  DT.40129291 
    DT.120777678  DT.100775735 

    Selected AceView cDNA sequences (see all 146):

    BQ958701 BM680549 BQ439546 D12422 BI260853 NM_032876 BC007580 BM479543 
    CN482905 AY169959 CA442366 NM_198086 BU543883 BM718100 CB135297 BQ232031 
    BU149830 AI918246 BU163376 AA909473 AW014157 CB106008 BG113736 AW340355 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AJUBA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTGGATAT
    AJUBA Expression
    About this image


    AJUBA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Eye (Sensory Organs)
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    AJUBA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AJUBA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655832
        Custom PCR Arrays for AJUBA
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AJUBA gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ajuba1 , 5 ajuba5
    ajuba LIM protein1
    88.27(n)1
    93.67(a)1
      14 (27.84 cM)5
    164751  NM_010590.51  NP_034720.21 
     545674695 
    zebrafish
    (Danio rerio)
    Actinopterygii ajuba6
    ajuba LIM protein
    35(a)
    1 ↔ 1
    7(25267250-25278340) ENSDARG00000077842
    fruit fly
    (Drosophila melanogaster)
    Insecta jub6
    Ajuba LIM protein
    25(a)
    1 → many
    X(13720363-13724347)


    ENSEMBL Gene Tree for AJUBA (if available)
    TreeFam Gene Tree for AJUBA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AJUBA gene
    LPP2  FBLIM12  TRIP62  ABLIM32  WTIP2  DMTN2  ZYX2  ABLIM22  
    LIMD12  ABLIM12  
    8 SIMAP similar genes for AJUBA using alignment to 4 protein entries:     AJUBA_HUMAN (see all proteins):
    WTIP    CSRP1    DKFZp686P2249    LIMD1    FHL2    LIMS2
    ABLIM1    PDLIM5

    Find genes that share paralogs with AJUBA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AJUBA (see all 260)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1849698691,2
    --23439954(+) AACCCA/GGGAGA 2 -- ds50010--------
    rs1115392601,2
    C,F--23439961(+) GAGACG/TGAGGT 2 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1890346011,2
    --23440038(+) AAAAAA/CCCTGA 2 -- ds50010--------
    rs598410881,2
    C--23440049(+) GAGCCG/AGGCAC 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs118443621,2
    H--23440080(+) ccagcA/Cctttg 2 -- ds50010--------
    rs346153461,2
    C,F--23440281(+) GATAGC/TGCCAC 2 -- ds50013Minor allele frequency- T:0.33NA 6
    rs21808341,2
    C,F,H--23440404(+) TCATAG/AGGCCT 2 -- ds500125Minor allele frequency- A:0.18NA NS EA WA 2902
    rs121470251,2
    C,F,H--23440742(+) AAACCA/GATTAG 2 -- ut3117Minor allele frequency- G:0.11NS EA NA 2224
    rs1389763251,2
    --23441018(+) ATACAA/CAAAAT 2 -- ut310--------
    rs1428779271,2
    --23441041(+) TGTATC/TTATTG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for AJUBA (23440383 - 23451851 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AJUBA: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AJUBA
    DNA2.0 Custom Variant and Variant Library Synthesis for AJUBA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609066    OMIM disorders: --


    Find genes that share disorders with AJUBA           About GenesLikeMe


    Export disorders for AJUBA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AJUBA gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with AJUBA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. (PubMed id 22286099)1, 2 Foxler D.E.... Sharp T.V. (Nat. Cell Biol. 2012)
    2. Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. (PubMed id 18331720)1, 2 Langer E.M....Longmore G.D. (Dev. Cell 2008)
    3. Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor. (PubMed id 18805794)1, 2 Montoya-Durango D.E.... Grimes H.L. (J. Biol. Chem. 2008)
    4. LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. (PubMed id 16413547)1, 2 Abe Y.... Yamamoto T. (FEBS Lett. 2006)
    5. The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex. (PubMed id 15870274)1, 2 Feng Y. and Longmore G.D. (Mol. Cell. Biol. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. (PubMed id 12417594)1, 2 Marie H.... Braga V.M. (J. Biol. Chem. 2003)
    8. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. (PubMed id 13678582)1, 2 Hirota T.... Saya H. (Cell 2003)
    9. Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. (PubMed id 10330178)1, 3 Goyal R.K....Longmore G.D. (Mol. Cell. Biol. 1999)
    10. Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances. (PubMed id 23704328)1 Fatemifar G....Evans D.M. (Hum. Mol. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84962 HGNC: 20250 AceView: JUB Ensembl:ENSG00000129474 euGenes: HUgn84962
    ECgene: AJUBA Kegg: 84962 H-InvDB: AJUBA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AJUBA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AJUBA gene:
    Search GeneIP for patents involving AJUBA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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