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Aliases for AJAP1 Gene

Aliases for AJAP1 Gene

  • Adherens Junctions Associated Protein 1 2 3
  • SHREW1 3 4 6
  • Transmembrane Protein SHREW1 2 3
  • Membrane Protein Shrew-1 3 4
  • MOT8 3 4
  • Adherens Junction Associated Protein 1 3
  • Adherens Junction-Associated Protein 1 3
  • SHREW-1 3

External Ids for AJAP1 Gene

Previous GeneCards Identifiers for AJAP1 Gene

  • GC01P004626
  • GC01P003862

Summaries for AJAP1 Gene

GeneCards Summary for AJAP1 Gene

AJAP1 (Adherens Junctions Associated Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for AJAP1 Gene

  • Plays a role in cell adhesion and cell migration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AJAP1 Gene

Genomics for AJAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AJAP1 Gene

4,654,732 bp from pter
4,792,534 bp from pter
137,803 bases
Plus strand

Genomic View for AJAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AJAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AJAP1 Gene

No data available for Regulatory Elements for AJAP1 Gene

Proteins for AJAP1 Gene

  • Protein details for AJAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adherens junction-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • Q9Y229

    Protein attributes for AJAP1 Gene

    411 amino acids
    Molecular mass:
    44536 Da
    Quaternary structure:
    • Forms a complex with CDH1 and CTNNB1; interacts directly with CTNNB1. Interacts with AP1M2 and BSG/CD147.
    • Sequence=CAB41245.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB41246.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for AJAP1 Gene

Proteomics data for AJAP1 Gene at MOPED

Post-translational modifications for AJAP1 Gene

  • Thr-237 and Ser-239 may be phosphorylated; however as this position is probably extracellular, the in vivo relevance is not proven
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AJAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for AJAP1 (Shrew-1/AJAP1)

No data available for DME Specific Peptides for AJAP1 Gene

Domains for AJAP1 Gene

Protein Domains for AJAP1 Gene


Suggested Antigen Peptide Sequences for AJAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AJAP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for AJAP1 Gene

Function for AJAP1 Gene

Molecular function for AJAP1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell adhesion and cell migration.
genes like me logo Genes that share phenotypes with AJAP1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AJAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AJAP1 Gene

Localization for AJAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AJAP1 Gene

Basolateral cell membrane; Single-pass type III membrane protein. Apical cell membrane; Single-pass type III membrane protein. Cell junction, adherens junction. Note=Mainly basolateral. Localization is mediated by AP1M2.

Subcellular locations from

Jensen Localization Image for AJAP1 Gene COMPARTMENTS Subcellular localization image for AJAP1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for AJAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0005912 adherens junction IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with AJAP1: view

Pathways for AJAP1 Gene

SuperPathways for AJAP1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for AJAP1 Gene

Gene Ontology (GO) - Biological Process for AJAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with AJAP1: view

No data available for Pathways by source for AJAP1 Gene

Transcripts for AJAP1 Gene

Unigene Clusters for AJAP1 Gene

Adherens junctions associated protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AJAP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AJAP1 Gene

No ASD Table

Relevant External Links for AJAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AJAP1 Gene

mRNA expression in normal human tissues for AJAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AJAP1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.0), Brain - Anterior cingulate cortex (BA24) (4.9), Brain - Cortex (4.9), and Brain - Nucleus accumbens (basal ganglia) (4.4).

Protein differential expression in normal tissues for AJAP1 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AJAP1 Gene

SOURCE GeneReport for Unigene cluster for AJAP1 Gene Hs.25924

mRNA Expression by UniProt/SwissProt for AJAP1 Gene

Tissue specificity: Expressed in uterus and pancreas (at protein level).
genes like me logo Genes that share expressions with AJAP1: view

Expression partners for AJAP1 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for AJAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AJAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AJAP1 35
  • 85.61 (n)
  • 85.85 (a)
AJAP1 36
  • 83 (a)
(Canis familiaris)
Mammalia AJAP1 35
  • 84.47 (n)
  • 82.44 (a)
AJAP1 36
  • 83 (a)
(Mus musculus)
Mammalia Ajap1 35
  • 81.94 (n)
  • 80.39 (a)
Ajap1 16
Ajap1 36
  • 80 (a)
(Pan troglodytes)
Mammalia AJAP1 35
  • 99.03 (n)
  • 99.51 (a)
AJAP1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ajap1 35
  • 80.34 (n)
  • 79.61 (a)
(Monodelphis domestica)
Mammalia AJAP1 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia AJAP1 36
  • 44 (a)
(Gallus gallus)
Aves AJAP1 35
  • 68.53 (n)
  • 62.42 (a)
AJAP1 36
  • 60 (a)
(Anolis carolinensis)
Reptilia AJAP1 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ajap1 35
  • 66.33 (n)
  • 68.47 (a)
Str.12381 35
(Danio rerio)
Actinopterygii LOC101887016 35
  • 55.26 (n)
  • 48.13 (a)
ajap1 36
  • 46 (a)
Species with no ortholog for AJAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AJAP1 Gene

Gene Tree for AJAP1 (if available)
Gene Tree for AJAP1 (if available)

Paralogs for AJAP1 Gene

No data available for Paralogs for AJAP1 Gene

Variants for AJAP1 Gene

Sequence variations from dbSNP and Humsavar for AJAP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs171380 -- 4,692,218(+) CAGGC(A/G)GGCTC intron-variant
rs187148 -- 4,689,953(+) AGGCT(C/G)CCTGG intron-variant
rs242040 -- 4,719,228(+) AATGA(A/G)CCATC intron-variant
rs242041 -- 4,719,637(+) CTCCC(C/G)GCAGC intron-variant
rs242042 -- 4,725,471(+) GTACA(C/T)GTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AJAP1 Gene

Variant ID Type Subtype PubMed ID
nsv871137 CNV Gain 21882294
nsv871520 CNV Loss 21882294
nsv825475 CNV Gain 20364138
esv2734250 CNV Deletion 23290073
esv2734361 CNV Deletion 23290073
nsv871046 CNV Loss 21882294
esv1009421 CNV Deletion 20482838
nsv460505 CNV Loss 19166990
nsv520031 CNV Loss 19592680
nsv521535 CNV Loss 19592680
nsv460617 CNV Loss 19166990
nsv830870 CNV Loss 17160897
esv2651800 CNV Insertion 19546169
nsv830981 CNV Gain 17160897

Relevant External Links for AJAP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AJAP1 Gene

Disorders for AJAP1 Gene

Relevant External Links for AJAP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for AJAP1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for AJAP1 Gene

Publications for AJAP1 Gene

  1. Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells. (PMID: 14595118) Bharti S. … Starzinski-Powitz A. (Mol. Biol. Cell 2004) 2 3 4
  2. junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147. (PMID: 17267690) Schreiner A. … Starzinski-Powitz A. (Mol. Biol. Cell 2007) 3 4
  3. The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration. (PMID: 16410724) McDonald J.M. … Zhang W. (Cancer Biol. Ther. 2006) 3 4
  4. Targeting of transmembrane protein shrew-1 to adherens junctions is controlled by cytoplasmic sorting motifs. (PMID: 16707570) Jakob V. … Starzinski-Powitz A. (Mol. Biol. Cell 2006) 3 4
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48

Products for AJAP1 Gene

Sources for AJAP1 Gene

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