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Aliases for AIRN Gene

Subcategory (RNA class) for AIRN Gene

antisense

Quality Score for this RNA gene is

3

Aliases for AIRN Gene

  • Antisense Of IGF2R Non-Protein Coding RNA 2 3 5
  • IGF2R Antisense RNA 1 (Non-Protein Coding) 2 3
  • Antisense Of IGF2R RNA (Non-Protein Coding) 2
  • Non-Protein Coding RNA 88 2
  • NCRNA00088 3
  • IGF2R-AS1 3
  • IGF2R-AS 3
  • IGF2RAS 3
  • AIR 3

External Ids for AIRN Gene

ORGUL Members for AIRN Gene

Previous GeneCards Identifiers for AIRN Gene

  • GC00U922835
  • GC06U901606
  • GC06M160424

Summaries for AIRN Gene

Entrez Gene Summary for AIRN Gene

  • Both spliced and un-spliced long non-coding RNAs are transcribed from this gene. This gene overlaps on the opposite strand the second intron of the insulin-like growth factor 2 receptor gene; a CpG island associated with the second intron denotes an active promoter that drives the expression of this gene. The related mouse gene is responsible for silencing the insulin-like growth factor 2 receptor gene and flanking genes in the imprinted gene cluster of mice. This gene may be expressed in Wilms tumors. [provided by RefSeq, Feb 2013]

GeneCards Summary for AIRN Gene

AIRN (Antisense Of IGF2R Non-Protein Coding RNA) is an RNA Gene, and is affiliated with the antisense RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AIRN Gene

Genomics for AIRN Gene

Regulatory Elements for AIRN Gene

Enhancers for AIRN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F160006 1.2 FANTOM5 Ensembl 0.8 +1.4 1364 0.6 ZNF202 CBX3 SIN3A MNT REST RAD21 CHAMP1 NR2F2 ATF3 HNF4G MAS1 ENSG00000236823 SLC22A1 AIRN IGF2R
GH06F160009 0.7 ENCODE 0.8 -2.9 -2864 1.9 DIDO1 RAD51 USF2 KLF8 WT1 IGF2R SLC22A3 AIRN GC06P160073
GH06F159999 1.1 Ensembl ENCODE 0.4 +8.2 8191 0.5 BCOR HDAC1 CBX3 DDX20 TAL1 ETV1 ZNF175 NCOR1 STAT2 TRIM24 IGF2R LOC729603 SLC22A1 AIRN
GH06F160013 0.4 ENCODE 0.4 -7.8 -7836 3.1 ELF3 FOXA3 MAFG MAFF ZNF316 ZBTB33 MAFK EMSY HOMEZ IGF2R LOC729603 SLC22A1 AIRN GC06P160073
GH06F159996 0.4 ENCODE 0.4 +10.7 10721 0.2 CEBPB CEBPG IGF2R AIRN
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around AIRN on UCSC Golden Path with GeneCards custom track

Genomic Location for AIRN Gene

Chromosome:
6
Start:
160,003,291 bp from pter
End:
160,007,664 bp from pter
Size:
4,374 bases
Orientation:
Minus strand

Genomic View for AIRN Gene

Genes around AIRN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AIRN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AIRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AIRN Gene

Proteins for AIRN Gene

Post-translational modifications for AIRN Gene

No Post-translational modifications

No data available for DME Specific Peptides for AIRN Gene

Domains & Families for AIRN Gene

Gene Families for AIRN Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AIRN: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for AIRN Gene

Function for AIRN Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AIRN Gene

Localization for AIRN Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for AIRN Gene

Pathways & Interactions for AIRN Gene

SuperPathways for AIRN Gene

No Data Available

Interacting Proteins for AIRN Gene

Gene Ontology (GO) - Biological Process for AIRN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for AIRN Gene

Transcripts for AIRN Gene

mRNA/cDNA for AIRN Gene

(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AIRN Gene

Antisense of IGF2R non-protein coding RNA:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AIRN Gene

No ASD Table

Relevant External Links for AIRN Gene

GeneLoc Exon Structure for
AIRN
ECgene alternative splicing isoforms for
AIRN

Expression for AIRN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AIRN Gene

mRNA differential expression in normal tissues according to GTEx for AIRN Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.7), Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Cortex (x6.0), and Brain - Hypothalamus (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of AIRN Gene:

AIRN

SOURCE GeneReport for Unigene cluster for AIRN Gene:

Hs.742166
genes like me logo Genes that share expression patterns with AIRN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for AIRN Gene

Orthologs for AIRN Gene

Evolution for AIRN Gene

ENSEMBL:
Gene Tree for AIRN (if available)
TreeFam:
Gene Tree for AIRN (if available)

No data available for Orthologs for AIRN Gene

Paralogs for AIRN Gene

No data available for Paralogs for AIRN Gene

Variants for AIRN Gene

Sequence variations from dbSNP and Humsavar for AIRN Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1003737 -- 160,009,624(-) ACAAT(G/T)ATGTC intron-variant, upstream-variant-2KB
rs10945647 -- 160,006,479(+) CACTG(A/T)CCTTG intron-variant, nc-transcript-variant, splice-donor-variant
rs10945648 -- 160,006,612(+) CAGAA(C/G)AACCA intron-variant, nc-transcript-variant
rs10945649 -- 160,007,529(+) ATGTC(A/T)TGTTC intron-variant, nc-transcript-variant
rs111320777 -- 160,004,515(+) GCAAG(C/T)GCTAT intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for AIRN Gene

Variant ID Type Subtype PubMed ID
esv2759484 CNV gain+loss 17122850
esv35098 CNV gain 17911159
nsv1074441 CNV deletion 25765185

Relevant External Links for AIRN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AIRN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for AIRN Gene

Disorders for AIRN Gene

Relevant External Links for AIRN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AIRN

No disorders were found for AIRN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AIRN Gene

Publications for AIRN Gene

  1. Identification of the human homolog of the imprinted mouse Air non-coding RNA. (PMID: 18789384) Yotova I.Y. … Barlow D.P. (Genomics 2008) 2 3 64
  2. Silencing and transcriptional properties of the imprinted Airn ncRNA are independent of the endogenous promoter. (PMID: 19008856) Stricker S.H. … Barlow D.P. (EMBO J. 2008) 2 3 64
  3. A downstream CpG island controls transcript initiation and elongation and the methylation state of the imprinted Airn macro ncRNA promoter. (PMID: 22396659) Koerner M.V. … Barlow D.P. (PLoS Genet. 2012) 3 64
  4. Long non-coding RNA modifies chromatin: epigenetic silencing by long non-coding RNAs. (PMID: 21915889) Saxena A. … Carninci P. (Bioessays 2011) 3 64
  5. Kcnq1ot1: a chromatin regulatory RNA. (PMID: 21345374) Kanduri C. (Semin. Cell Dev. Biol. 2011) 3 64

Products for AIRN Gene

Sources for AIRN Gene

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