Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AIP Gene

protein-coding   GIFtS: 62
GCID: GC11P067251

Aryl Hydrocarbon Receptor Interacting Protein

(Previous name: aryl hydrocarbon receptor-interacting protein)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Aryl Hydrocarbon Receptor Interacting Protein1 2     Aryl Hydrocarbon Receptor-Interacting Protein1
XAP22 3 5     FKBP162
Immunophilin Homolog ARA92 3     FKBP372
XAP-22 3     SMTPHN2
HBV X-Associated Protein 22 3     AH Receptor-Interacting Protein2
ARA92 5     Aryl-Hydrocarbon Receptor-Interacting Protein3

External Ids:    HGNC: 3581   Entrez Gene: 90492   Ensembl: ENSG000001107117   OMIM: 6055555   UniProtKB: O001703   

Export aliases for AIP gene to outside databases

Previous GC identifers: GC11P069773 GC11P068946 GC11P067500 GC11P067026 GC11P067027 GC11P067007 GC11P063579


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AIP Gene:
The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor.
The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is
transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes.
Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. (provided by
RefSeq, Sep 2008)

GeneCards Summary for AIP Gene: 
AIP (aryl hydrocarbon receptor interacting protein) is a protein-coding gene. Diseases associated with AIP include familial isolated pituitary adenoma, and aip-related familial isolated pituitary adenomas. GO annotations related to this gene include transcription coactivator activity and transcription factor binding. An important paralog of this gene is AIPL1.

UniProtKB/Swiss-Prot: AIP_HUMAN, O00170
Function: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by
influencing its receptivity for ligand and/or its nuclear targeting
Function: Cellular negative regulator of the hepatitis B virus (HBV) X protein

Gene Wiki entry for AIP (AH receptor-interacting protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AIP gene promoter:
         PPAR-alpha   AhR   FAC1   PPAR-gamma1   Pax-5   PPAR-gamma2   Pax-4a   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAIP promoter sequence
   Search SABiosciences Chromatin IP Primers for AIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.3

AIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AIP gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P067251:  view genomic region     (about GC identifiers)

Start:
67,250,505 bp from pter      End:
67,258,579 bp from pter
Size:
8,075 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AIP_HUMAN, O00170 (See protein sequence)
Recommended Name: AH receptor-interacting protein  
Size: 330 amino acids; 37636 Da
Subunit: Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin
complex
Subcellular location: Cytoplasm
3 PDB 3D structures from and Proteopedia for AIP:
2LKN (3D)        4AIF (3D)        4APO (3D)    
Secondary accessions: A0SZW3 A0SZW4 A0SZW5 A0SZW6 Q2M3Q2 Q99606

Explore the universe of human proteins at neXtProt for AIP: NX_O00170

Explore proteomics data for AIP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00170

  • AIP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AIP Protein Expression
    REFSEQ proteins: NP_003968.2  
    ENSEMBL proteins: 
     ENSP00000434982   ENSP00000279146   ENSP00000434580  

    Human Recombinant Protein Products for AIP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for AIP
    OriGene Protein Over-expression Lysate for AIP
    OriGene MassSpec for AIP 
    OriGene Custom Protein Services for AIP
    GenScript Custom Purified and Recombinant Proteins Services for AIP
    Novus Biologicals AIP Proteins
    Novus Biologicals AIP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for AIP
    Cloud-Clone Corp. Proteins for AIP 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS14557246
    GO:0005886colocalizes with plasma membrane IDA17329248

    AIP for ontologies           About GeneDecksing



    AIP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for AIP
    OriGene Custom Antibody Services for AIP
    GenScript Superior Antibodies for AIP
    Novus Biologicals AIP Antibodies
    Abcam antibodies for AIP
    Cloud-Clone Corp. Antibodies for AIP 
    ThermoFisher Antibody for AIP
    LSBio Antibodies in human, mouse, rat for AIP 

    Assay Products for AIP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AIP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AIP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AIP 
    Cloud-Clone Corp. CLIAs for AIP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR001179 PPIase_FKBP_dom
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry O00170

    ProtoNet protein and cluster: O00170

    UniProtKB/Swiss-Prot: AIP_HUMAN, O00170
    Similarity: Contains 1 PPIase FKBP-type domain
    Similarity: Contains 2 TPR repeats


    AIP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AIP_HUMAN, O00170
    Function: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by
    influencing its receptivity for ligand and/or its nuclear targeting
    Function: Cellular negative regulator of the hepatitis B virus (HBV) X protein

         Genatlas biochemistry entry for AIP:
    arylhydrocarbon receptor associated protein,immunophilin homolog,interacting with HSP90-AHR complex,homologous to
    the 52kDa,FK506 binding protein (FKBP52)

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003712transcription cofactor activity ----
    GO:0003713transcription coactivator activity TAS9447995
    GO:0003755peptidyl-prolyl cis-trans isomerase activity ----
    GO:0004871signal transducer activity TAS9111057
    GO:0005515protein binding IPI14557246
         
    AIP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AIP:
     Decreased homologous recombina 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Aip):
     cardiovascular system  embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     integument  liver/biliary system  mortality/aging  tumorigenesis 

    AIP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Aiptm1Bra for AIP

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AIP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AIP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AIP 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AIP
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate AIP:
    hsa-miR-194* hsa-miR-577 hsa-miR-3142
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AIP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AIP
    Sirion Biotech Customized adenovirus for overexpression of AIP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for AIP (see all 7)
    OriGene ORF clones in mouse, rat for AIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): AIP (NM_004536)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIP
    Sirion Biotech Customized lentivirus for stable overexpression of AIP 
                         Customized lentivirus expression plasmids for stable overexpression of AIP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AIP
    Search LifeMap BioReagents cell lines for AIP
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AIP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1AhR pathway
    AhR pathway
    2AHR Pathway
    AHR Pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AIP
        AHR Pathway

    1 BioSystems Pathway for AIP
        AhR pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/25 Interacting proteins for AIP (O001701, 2, 3 ENSP000002791464) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRF7Q929851, 3, ENSP000003294114EBI-704197,EBI-968267 I2D: score=1 STRING: ENSP00000329411
    HSP90AB1P082382, 3, ENSP000003258754MINT-7021862 I2D: score=1 STRING: ENSP00000325875
    PDE2AO004081, 3, ENSP000003349104EBI-704197,EBI-1785967 I2D: score=1 STRING: ENSP00000334910
    AHRP358693, ENSP000002420574I2D: score=8 STRING: ENSP00000242057
    PPARAQ078693, ENSP000002627354I2D: score=2 STRING: ENSP00000262735
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding ----
    GO:0006626protein targeting to mitochondrion IDA14557246
    GO:0006805xenobiotic metabolic process IEA--
    GO:0007165signal transduction TAS9111057
    GO:0010738regulation of protein kinase A signaling cascade IEA--

    AIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AIP

    Search CenterWatch for drugs/clinical trials and news about AIP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AIP gene: 
    NM_003977.2  

    Unigene Cluster for AIP:

    Aryl hydrocarbon receptor interacting protein
    Hs.412433  [show with all ESTs]
    Unigene Representative Sequence: BG913006
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528641 ENST00000279146(uc001olv.3) ENST00000529797 ENST00000525341

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AIP
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate AIP:
    hsa-miR-194* hsa-miR-577 hsa-miR-3142
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AIP
    Clone
    Products:
         
    OriGene clones in human, mouse for AIP (see all 7)
    OriGene ORF clones in mouse, rat for AIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): AIP (NM_004536)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIP
    Sirion Biotech Customized lentivirus for stable overexpression of AIP 
                         Customized lentivirus expression plasmids for stable overexpression of AIP 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AIP
    OriGene qSTAR qPCR primer pairs in human, mouse for AIP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AIP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AIP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AIP

    Additional mRNA sequence: 

    BC104797.1 BC104827.1 U31913.1 U78521.1 

    12 DOTS entries:

    DT.75147837  DT.100796850  DT.100796855  DT.100796857  DT.120759409  DT.91757342  DT.95371818  DT.95371806 
    DT.91757336  DT.95279473  DT.95342429  DT.95371808 

    24/451 AceView cDNA sequences (see all 451):

    BI834098 BQ062331 BM756022 BM016514 BQ944609 BG821308 BE795399 BE791743 
    CR620315 BE267706 AL548094 BG477719 BQ674196 CR601190 CR600563 CR601003 
    BQ694050 BE378867 BI859906 BI763490 BU785030 BU190162 CR600666 BG024960 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for AIP    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
    SP1:                                                  -               
    SP2:              -                                                   
    SP3:                                                                  
    SP4:              -                 -                                 
    SP5:              -     -     -     -                                 


    ECgene alternative splicing isoforms for AIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AIP Expression
    About this image


    See AIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AIP

    SOURCE GeneReport for Unigene cluster: Hs.412433

    UniProtKB/Swiss-Prot: AIP_HUMAN, O00170
    Tissue specificity: Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed
    in the liver

        SABiosciences Expression via Pathway-Focused PCR Array including AIP: 
              Mitochondria in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AIP
    OriGene qSTAR qPCR primer pairs in human, mouse for AIP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AIP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AIP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AIP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for AIP gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aip1 , 5 aryl-hydrocarbon receptor-interacting protein1, 5 88.59(n)1
    94.24(a)1
      19 (3.82 cM)5
    116321  NM_016666.21  NP_057875.11 
     41144465 
    chicken
    (Gallus gallus)
    Aves AIP1 aryl hydrocarbon receptor interacting protein 80.08(n)
    80.19(a)
      395123  NM_204469.1  NP_989800.1 
    lizard
    (Anolis carolinensis)
    Reptilia AIP6
    Uncharacterized protein
    81(a)
    1 ↔ 1
    1(94169271-94177527)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.80542 Xenopus laevis transcribed sequence with weak similarity to protein refNP_003968.1 (H.sapiens) aryl hydrocarbon receptor-interacting protein; HBV-X associated protein [Homo sapiens] less 74.97(n)    BX848099.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF274877.12   -- 79.15(n)    AF274877.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG18471 , 3 aryl hydrocarbon-receptor binding3
    CG18471
    39(a)3
    51.89(n)1
    40.13(a)1
      10F23
    321441  NM_132530.31  NP_572758.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C56C10.101 , 3 TPR domain3
    Protein C56C10.101
    34(a)3
    44.62(n)1
    36.39(a)1
      II(6592533-6594197)3
    1740921  NM_062938.21  NP_495339.11 


    ENSEMBL Gene Tree for AIP (if available)
    TreeFam Gene Tree for AIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AIP gene
    AIPL12  
    2 SIMAP similar genes for AIP using alignment to 34 protein entries:     AIP_HUMAN (see all proteins):
    AIPL1    DKFZp686O2183

    AIP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/315 SNPs in AIP are shown (see all 315)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048941941,2
    Cpathogenic167170281(+) GGATCC/TAAAAA 2 Q * stg10--------
    rs2676065731,2
    Cpathogenic167177475(+) AGTGCA/G/TAGCTG 3 K E * mis1 stg10--------
    rs1219083561,2
    Cpathogenic167177888(+) GCCTAA/CTTCAA 2 * Y stg10--------
    rs1394075671,2
    C,Fpathogenic167177891(+) TACTTC/TAAGCG 2 F syn11Minor allele frequency- T:0.00NA 4492
    rs1048941951,2
    Cpathogenic167177994(+) TGAGCC/TGAGAG 2 R * stg10--------
    rs1048941901,2
    Cpathogenic167177995(+) GAGCCG/AAGAGC 2 /Q /R mis12Minor allele frequency- A:0.00NA EU 4709
    rs1819690661,2
    Cprobable-non-pathogenic167174121(+) GACGAC/TGAGGG 2 D syn10--------
    rs1048950721,2
    Cprobable-pathogenic167174235(+) GAAGGG/TGAGAT 2 G syn10--------
    rs1048950731,2
    Cprobable-pathogenic167177143(+) CGTACC/TAGCAG 2 Q * stg10--------
    rs2676065611,2
    Cprobable-pathogenic167177237(+) GCATGC/TGAAGG 2 A V mis10--------

    HapMap Linkage Disequilibrium report for AIP (67250505 - 67258579 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for AIP:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422195CNV Duplication17116639
    nsv368CNV Insertion18451855
    nsv468604CNV Loss19166990
    nsv527056CNV Loss19592680
    nsv897797CNV Loss21882294
    nsv521723CNV Loss19592680
    dgv1194n71CNV Loss21882294
    dgv1193n71CNV Loss21882294
    nsv897801CNV Loss21882294
    nsv825960CNV Gain20364138


    Human Gene Mutation Database (HGMD): AIP
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AIP
    DNA2.0 Custom Variant and Variant Library Synthesis for AIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605555   
    OMIM disorders: 102200  600634  219090  
    UniProtKB/Swiss-Prot: AIP_HUMAN, O00170
  • Growth hormone-secreting pituitary adenoma (GHSPA) [MIM:102200]: Pituitary adenomas include
    somatotropinoma and prolactinoma. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • ACTH-secreting pituitary adenoma (ASPA) [MIM:219090]: A pituitary adenoma resulting in excessive
    production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and
    ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and truncal obesity,
    abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Prolactin-secreting pituitary adenoma (PSPA) [MIM:600634]: Most common type of hormonally active
    pituitary adenoma. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/29 diseases for AIP (see all 29):    About MalaCards
    familial isolated pituitary adenoma    aip-related familial isolated pituitary adenomas    pituitary adenoma    hepatitis b
    acromegaly    prolactin producing pituitary tumor    acth-secreting pituitary adenoma    wermer syndrome
    growth hormone secreting pituitary adenoma    gigantism    carney complex    prolactinoma
    pituitary tumors    primary hyperparathyroidism    adenoma    noma
    hepatitis    cushing's syndrome    hyperparathyroidism    multiple endocrine neoplasia

    6 diseases from the University of Copenhagen DISEASES database for AIP:
    Hormone producing pituitary cancer     Pituitary adenoma     Carney complex     Wermer syndrome
    Adenoma     Acromegaly

    AIP for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for AIP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary adenoma 85.6 35 17916996 (5), 18381572 (3), 19684062 (3), 17893250 (3) (see all 16)
    acromegaly 81.4 9 17371465 (1), 18381572 (1), 17916996 (1), 19883897 (1) (see all 6)
    prolactinoma 81.2 1 17244780 (1)
    gigantism 77.6 2 17371465 (1), 17609395 (1)
    pituitary tumors 73 15 19188737 (4), 17893251 (2), 17916996 (2), 18787049 (1) (see all 6)
    adenoma 53.5 10 17371465 (3), 18381572 (2), 19883897 (2), 17916996 (1) (see all 6)
    hepatitis b 41.3 9 14730974 (2), 9447995 (1), 10777214 (1), 11955954 (1) (see all 8)
    somatic mutations 27.3 1 17371465 (1)
    shock 18.7 2 9837941 (1), 11093792 (1)
    tumors 0 17 17244780 (3), 20454499 (3), 17609395 (2), 18381572 (2) (see all 7)

    Genetic Association Database (GAD): AIP
    Human Genome Epidemiology (HuGE) Navigator: AIP (31 documents)

    Export disorders for AIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AIP gene, integrated from 9 sources (see all 119):
    (articles sorted by number of sources associating them with AIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation. (PubMed id 8972861)1, 2, 3, 9 Kuzhandaivelu N.... Seto E. (1996)
    2. Mutations in the aryl hydrocarbon receptor interacting protein gene are not highly prevalent among subjects with sporadic pituitary adenomas. (PubMed id 17299063)1, 2, 4 Barlier A.... Beckers A. (2007)
    3. Pituitary adenoma predisposition caused by germline mutations in the AIP gene. (PubMed id 16728643)1, 2, 4 Vierimaa O....Aaltonen L.A. (2006)
    4. Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo. (PubMed id 9111057)1, 2, 3 Carver L.A. and Bradfield C.A. (1997)
    5. Aryl hydrocarbon receptor-interacting protein gene mutations in familial isolated pituitary adenomas: analysis in 73 families. (PubMed id 17244780)1, 2, 9 Daly A.F.... Beckers A. (2007)
    6. Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations. (PubMed id 17360484)1, 2, 9 Georgitsi M.... Aaltonen L.A. (2007)
    7. Assessment of p27 (cyclin-dependent kinase inhibitor 1B) and AIP (aryl hydrocarbon receptor-interacting protein) genes in MEN1 syndrome patients without any detectable MEN1 gene mutations. (PubMed id 18710468)1, 4, 9 Igreja S....Korbonits M. (2008)
    8. Germline inactivating mutations of the aryl hydrocarbon receptor- interacting protein gene in a large cohort of sporadic acromegaly: mutations are found in a subset of young patients with macroadenomas. (PubMed id 17609395)1, 4, 9 Cazabat L.... Raffin-Sanson M.L. (2007)
    9. Mutation analysis of MEN1, HRPT2, CASR, CDKN1B, and A IP genes in primary hyperparathyroidism patients with features of genetic predi sposition. (PubMed id 19474519)1, 4, 9 Vierimaa O....Salmela P.I. (2009)
    10. The tyrosine kinase receptor RET interacts in vivo wi th aryl hydrocarbon receptor-interacting protein to alter survivin availability . (PubMed id 19366855)1, 2, 9 Vargiolu M....Bonora E. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9049 HGNC: 358 AceView: AIP Ensembl:ENSG00000110711 euGenes: HUgn9049
    ECgene: AIP H-InvDB: AIP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AIP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AIP Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/AIP

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AIP gene:
    Search GeneIP for patents involving AIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for AIP   OriGene RNAi products in human, mouse, rat for AIP  
     OriGene qPCR primer pairs and template standards for AIP   OriGene Protein Over-expression Lysate for AIP  
     OriGene MassSpec something-or-other for AIP   OriGene clones in human, mouse for AIP  
     OriGene qSTAR qPCR primer pairs in human, mouse for AIP   OriGene Purified Protein for AIP  
     OriGene ORF clones in mouse, rat for AIP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AIP   OriGene Custom Protein Services for AIP  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AIP
     QIAGEN SeqTarget long-range PCR primers for resequencing AIP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AIP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AIP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AIP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AIP
     GenScript Custom Purified and Recombinant Proteins Services for AIP GenScript cDNA clones with any tag delivered in your preferred vector for AIP
     GenScript Custom Assay Services for AIP GenScript Superior Antibodies for AIP
     GenScript Custom overexpressing Cell Line Services for AIP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in AIP promoter
     Search Chromatin IP Primers for AIP
     RT2 qPCR Primer Assay in human, mouse, rat AIP
     GNC Network for AIP
     SABiosciences PCR Arrays including human, mouse, rat AIP
     Search Tocris compounds for AIP
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     AIP antibodies
     AIP proteins
     AIP lysates
     Antibodies for AIP
     See all of Abcam's Antibodies, Kits and Proteins for AIP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for AIP




     Proteins for AIP
     Antibodies for AIP
     ELISAs for AIP
     CLIAs for AIP
     Search LifeMap BioReagents cell lines for AIP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIP
     Browse SwitchGear 3'UTR luciferase reporter plasmids for AIP
     SwitchGear Promoter luciferase reporter plasmids for AIP
     ThermoFisher Antibody for AIP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIP
     inGenious Targeting Laboratory - Custom generated mouse model solutions for AIP
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AIP
    Customized:
     lentivirus for stable overexpression of AIP
     lentivirus expression plasmids for stable overexpression of AIP
     adenovirus for overexpression of AIP
     LSBio Antibodies in human, mouse, rat for AIP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AIP gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4