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AIP Gene

protein-coding   GIFtS: 62
GCID: GC11P067251

Aryl Hydrocarbon Receptor Interacting Protein

(Previous name: aryl hydrocarbon receptor-interacting protein)
  See AIP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aryl Hydrocarbon Receptor Interacting Protein1 2     Aryl Hydrocarbon Receptor-Interacting Protein1
XAP22 3 5     FKBP162
Immunophilin Homolog ARA92 3     FKBP372
XAP-22 3     SMTPHN2
HBV X-Associated Protein 22 3     AH Receptor-Interacting Protein2
ARA92 5     Aryl-Hydrocarbon Receptor-Interacting Protein3

External Ids:    HGNC: 3581   Entrez Gene: 90492   Ensembl: ENSG000001107117   OMIM: 6055555   UniProtKB: O001703   

Export aliases for AIP gene to outside databases

Previous GC identifers: GC11P069773 GC11P068946 GC11P067500 GC11P067026 GC11P067027 GC11P067007 GC11P063579


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AIP Gene:
The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor.
The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is
transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes.
Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. (provided by
RefSeq, Sep 2008)

GeneCards Summary for AIP Gene:
AIP (aryl hydrocarbon receptor interacting protein) is a protein-coding gene. Diseases associated with AIP include familial isolated pituitary adenoma, and aip-related familial isolated pituitary adenomas. GO annotations related to this gene include transcription coactivator activity and transcription factor binding. An important paralog of this gene is AIPL1.

UniProtKB/Swiss-Prot: AIP_HUMAN, O00170
Function: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by
influencing its receptivity for ligand and/or its nuclear targeting
Function: Cellular negative regulator of the hepatitis B virus (HBV) X protein

Gene Wiki entry for AIP (AH receptor-interacting protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AIP gene promoter:
         PPAR-alpha   AhR   FAC1   PPAR-gamma1   Pax-5   PPAR-gamma2   Pax-4a   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAIP promoter sequence
   Search Chromatin IP Primers for AIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.3

AIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AIP gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P067251:  view genomic region     (about GC identifiers)

Start:
67,250,505 bp from pter      End:
67,258,579 bp from pter
Size:
8,075 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AIP_HUMAN, O00170 (See protein sequence)
Recommended Name: AH receptor-interacting protein  
Size: 330 amino acids; 37636 Da
Subunit: Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin
complex
3 PDB 3D structures from and Proteopedia for AIP:
2LKN (3D)        4AIF (3D)        4APO (3D)    
Secondary accessions: A0SZW3 A0SZW4 A0SZW5 A0SZW6 Q2M3Q2 Q99606

Explore the universe of human proteins at neXtProt for AIP: NX_O00170

Explore proteomics data for AIP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys33, Lys69, Lys103, Lys112, Lys177, Lys210, Lys273, Lys290
  • Modification sites at PhosphoSitePlus

  • See AIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003968.2  
    ENSEMBL proteins: 
     ENSP00000434982   ENSP00000279146   ENSP00000476993  

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    Cloud-Clone Corp. Proteins for AIP

     
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    antibodies-online peptides for AIP

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR001179 PPIase_FKBP_dom
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry O00170

    ProtoNet protein and cluster: O00170

    UniProtKB/Swiss-Prot: AIP_HUMAN, O00170
    Similarity: Contains 1 PPIase FKBP-type domain
    Similarity: Contains 2 TPR repeats


    Find genes that share domains with AIP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AIP_HUMAN, O00170
    Function: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by
    influencing its receptivity for ligand and/or its nuclear targeting
    Function: Cellular negative regulator of the hepatitis B virus (HBV) X protein

         Genatlas biochemistry entry for AIP:
    arylhydrocarbon receptor associated protein,immunophilin homolog,interacting with HSP90-AHR complex,homologous to
    the 52kDa,FK506 binding protein (FKBP52)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003712transcription cofactor activity ----
    GO:0003713transcription coactivator activity TAS9447995
    GO:0004871signal transducer activity TAS9111057
    GO:0005515protein binding IPI14557246
    GO:0008134transcription factor binding TAS9447995
         
    Find genes that share ontologies with AIP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for AIP:
     Decreased homologous recombina 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Aip):
     cardiovascular system  embryogenesis  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     integument  liver/biliary system  mortality/aging  tumorigenesis 

    Find genes that share phenotypes with AIP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Aiptm1Bra for AIP

       genOway: Develop your customized and physiologically relevant rodent model for AIP

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    Browse Sino Biological Human cDNA Clones
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    Addgene plasmids for AIP 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AIP_HUMAN, O00170: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus4
    chloroplast2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS14557246
    GO:0005886colocalizes with plasma membrane IDA17329248

    Find genes that share ontologies with AIP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AIP About    
    See pathways by source

    SuperPathContained pathways About
    1AhR pathway (WikiPathways)
    AhR pathway
    2AHR Pathway (Qiagen)
    AHR Pathway

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for AIP
        AHR Pathway

    1 BioSystems Pathway for AIP
        AhR pathway


        Pathway & Disease-focused RT2 Profiler PCR Array including AIP: 
              Mitochondria in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for AIP (O001701, 2, 3 ENSP000002791464) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRF7Q929851, 3, ENSP000003294114EBI-704197,EBI-968267 I2D: score=1 STRING: ENSP00000329411
    HSP90AB1P082382, 3, ENSP000003258754MINT-7021862 I2D: score=1 STRING: ENSP00000325875
    PDE2AO004081, 3, ENSP000003349104EBI-704197,EBI-1785967 I2D: score=1 STRING: ENSP00000334910
    AHRP358693, ENSP000002420574I2D: score=8 STRING: ENSP00000242057
    PPARAQ078693, ENSP000002627354I2D: score=2 STRING: ENSP00000262735
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding ----
    GO:0006626protein targeting to mitochondrion IDA14557246
    GO:0006805xenobiotic metabolic process IEA--
    GO:0007165signal transduction TAS9111057
    GO:0010738regulation of protein kinase A signaling IEA--

    Find genes that share ontologies with AIP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AIP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AIP gene: 
    NM_003977.2  

    Unigene Cluster for AIP:

    Aryl hydrocarbon receptor interacting protein
    Hs.412433  [show with all ESTs]
    Unigene Representative Sequence: BG913006
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528641 ENST00000279146(uc001olv.3) ENST00000529797 ENST00000525341

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate AIP:
    hsa-miR-194* hsa-miR-577 hsa-miR-3142
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AIP
      QuantiTect SYBR Green Assays in human, mouse, rat AIP
      QuantiFast Probe-based Assays in human, mouse, rat AIP

    Additional mRNA sequence: 

    BC104797.1 BC104827.1 U31913.1 U78521.1 

    12 DOTS entries:

    DT.75147837  DT.100796850  DT.100796855  DT.100796857  DT.120759409  DT.91757342  DT.95371818  DT.95371806 
    DT.91757336  DT.95279473  DT.95342429  DT.95371808 

    Selected AceView cDNA sequences (see all 451):

    CK430631 CN481851 BQ709140 CR601003 AL134984 CB119764 BM710808 BI763490 
    CR604647 CF454390 BM757004 CR601190 BG036053 BE559496 BU558013 BE886805 
    BQ927863 BI834098 BQ108633 CD674822 BU190162 BM012082 CR594744 BE378867 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for AIP    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
    SP1:                                                  -               
    SP2:              -                                                   
    SP3:                                                                  
    SP4:              -                 -                                 
    SP5:              -     -     -     -                                 


    ECgene alternative splicing isoforms for AIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AIP Expression
    About this image

    AIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AIP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.412433

    UniProtKB/Swiss-Prot: AIP_HUMAN, O00170
    Tissue specificity: Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed
    in the liver

        Pathway & Disease-focused RT2 Profiler PCR Array including AIP: 
              Mitochondria in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AIP gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aip1 , 5 aryl-hydrocarbon receptor-interacting protein1, 5 88.59(n)1
    94.24(a)1
      19 (3.82 cM)5
    116321  NM_016666.31  NP_057875.11 
     41144465 
    chicken
    (Gallus gallus)
    Aves AIP1 aryl hydrocarbon receptor interacting protein 80.04(n)
    79.94(a)
      395123  NM_204469.1  NP_989800.1 
    lizard
    (Anolis carolinensis)
    Reptilia AIP6
    aryl hydrocarbon receptor interacting protein
    81(a)
    1 ↔ 1
    1(94169271-94177527)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.80542 Xenopus laevis transcribed sequence with weak similarity to protein refNP_003968.1 (H.sapiens) aryl hydrocarbon receptor-interacting protein; HBV-X associated protein [Homo sapiens] less 74.97(n)    BX848099.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF274877.12   -- 79.15(n)    AF274877.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG18471 , 3 aryl hydrocarbon-receptor binding3
    CG18471
    39(a)3
    51.88(n)1
    39.87(a)1
      10F23
    321441  NM_167311.21  NP_727574.21 
    worm
    (Caenorhabditis elegans)
    Secernentea C56C10.101 , 3 TPR domain3
    C56C10.101
    34(a)3
    44.62(n)1
    36.39(a)1
      II(6592533-6594197)3
    1740921  NM_062938.31  NP_495339.11 


    ENSEMBL Gene Tree for AIP (if available)
    TreeFam Gene Tree for AIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AIP gene
    AIPL12  
    2 SIMAP similar genes for AIP using alignment to 34 protein entries:     AIP_HUMAN (see all proteins):
    AIPL1    DKFZp686O2183

    Find genes that share paralogs with AIP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AIP (see all 315)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048941941,2
    Cpathogenic167170281(+) GGATCC/TAAAAA 2 Q * stg10--------
    rs2676065731,2
    Cpathogenic167177475(+) AGTGCA/G/TAGCTG 3 K E * mis1 stg10--------
    rs1219083561,2
    Cpathogenic167177888(+) GCCTAA/CTTCAA 2 * Y stg10--------
    rs1394075671,2
    C,Fpathogenic167177891(+) TACTTC/TAAGCG 2 F syn11Minor allele frequency- T:0.00NA 4492
    rs1048941951,2
    Cpathogenic167177994(+) TGAGCC/TGAGAG 2 R * stg10--------
    rs1048941901,2
    Cpathogenic167177995(+) GAGCCG/AAGAGC 2 /Q /R mis12Minor allele frequency- A:0.00NA EU 4709
    rs1819690661,2
    Cprobable-non-pathogenic167174121(+) GACGAC/TGAGGG 2 D syn10--------
    rs1048950721,2
    Cprobable-pathogenic167174235(+) GAAGGG/TGAGAT 2 G syn10--------
    rs1048950731,2
    Cprobable-pathogenic167177143(+) CGTACC/TAGCAG 2 Q * stg10--------
    rs2676065611,2
    Cprobable-pathogenic167177237(+) GCATGC/TGAAGG 2 A V mis10--------

    HapMap Linkage Disequilibrium report for AIP (67250505 - 67258579 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for AIP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422195CNV Duplication17116639
    nsv368CNV Insertion18451855
    nsv468604CNV Loss19166990
    nsv527056CNV Loss19592680
    nsv897797CNV Loss21882294
    nsv521723CNV Loss19592680
    dgv1194n71CNV Loss21882294
    dgv1193n71CNV Loss21882294
    nsv897801CNV Loss21882294
    nsv825960CNV Gain20364138

    Human Gene Mutation Database (HGMD): AIP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AIP
    DNA2.0 Custom Variant and Variant Library Synthesis for AIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605555   
    OMIM disorders: 102200  600634  219090  
    UniProtKB/Swiss-Prot: AIP_HUMAN, O00170
  • Growth hormone-secreting pituitary adenoma (GHSPA) [MIM:102200]: Pituitary adenomas include
    somatotropinoma and prolactinoma. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • ACTH-secreting pituitary adenoma (ASPA) [MIM:219090]: A pituitary adenoma resulting in excessive
    production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and
    ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and truncal obesity,
    abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Prolactin-secreting pituitary adenoma (PSPA) [MIM:600634]: Most common type of hormonally active
    pituitary adenoma. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 15 diseases for AIP:    
    About MalaCards
    familial isolated pituitary adenoma    aip-related familial isolated pituitary adenomas    growth hormone secreting pituitary adenoma    hormone producing pituitary cancer
    pituitary adenoma    prolactinoma    myh9-related disorders    acromegaly
    acth-secreting pituitary adenoma    hepatitis b    gigantism    carney complex
    wermer syndrome    pituitary apoplexy    hepatitis

    6 diseases from the University of Copenhagen DISEASES database for AIP:
    Hormone producing pituitary cancer     Pituitary adenoma     Carney complex     Wermer syndrome
    Adenoma     Acromegaly

    Find genes that share disorders with AIP           About GenesLikeMe

    10 Novoseek inferred disease relationships for AIP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary adenoma 85.6 35 17916996 (5), 18381572 (3), 19684062 (3), 17893250 (3) (see all 16)
    acromegaly 81.4 9 17371465 (1), 18381572 (1), 17916996 (1), 19883897 (1) (see all 6)
    prolactinoma 81.2 1 17244780 (1)
    gigantism 77.6 2 17371465 (1), 17609395 (1)
    pituitary tumors 73 15 19188737 (4), 17893251 (2), 17916996 (2), 18787049 (1) (see all 6)
    adenoma 53.5 10 17371465 (3), 18381572 (2), 19883897 (2), 17916996 (1) (see all 6)
    hepatitis b 41.3 9 14730974 (2), 9447995 (1), 10777214 (1), 11955954 (1) (see all 8)
    somatic mutations 27.3 1 17371465 (1)
    shock 18.7 2 9837941 (1), 11093792 (1)
    tumors 0 17 17244780 (3), 20454499 (3), 17609395 (2), 18381572 (2) (see all 7)

    Genetic Association Database (GAD): AIP
    Human Genome Epidemiology (HuGE) Navigator: AIP (31 documents)

    Export disorders for AIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AIP gene, integrated from 10 sources (see all 127):
    (articles sorted by number of sources associating them with AIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation. (PubMed id 8972861)1, 2, 3, 9 Kuzhandaivelu N.... Seto E. (Nucleic Acids Res. 1996)
    2. Mutations in the aryl hydrocarbon receptor interacting protein gene are not highly prevalent among subjects with sporadic pituitary adenomas. (PubMed id 17299063)1, 2, 4 Barlier A.... Beckers A. (J. Clin. Endocrinol. Metab. 2007)
    3. Pituitary adenoma predisposition caused by germline mutations in the AIP gene. (PubMed id 16728643)1, 2, 4 Vierimaa O....Aaltonen L.A. (Science 2006)
    4. Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo. (PubMed id 9111057)1, 2, 3 Carver L.A. and Bradfield C.A. (J. Biol. Chem. 1997)
    5. Aryl hydrocarbon receptor-interacting protein gene mutations in familial isolated pituitary adenomas: analysis in 73 families. (PubMed id 17244780)1, 2, 9 Daly A.F.... Beckers A. (J. Clin. Endocrinol. Metab. 2007)
    6. Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations. (PubMed id 17360484)1, 2, 9 Georgitsi M.... Aaltonen L.A. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    7. Assessment of p27 (cyclin-dependent kinase inhibitor 1B) and aryl hydrocarbon receptor-interacting protein (AIP) genes in multiple endocrine neoplasia (MEN1) syndrome patients without any detectable MEN1 gene mutations. (PubMed id 18710468)1, 4, 9 Igreja S....Korbonits M. (Clin. Endocrinol. (Oxf) 2009)
    8. Germline inactivating mutations of the aryl hydrocarbon receptor- interacting protein gene in a large cohort of sporadic acromegaly: mutations are found in a subset of young patients with macroadenomas. (PubMed id 17609395)1, 4, 9 Cazabat L.... Raffin-Sanson M.L. (Eur. J. Endocrinol. 2007)
    9. Mutation analysis of MEN1, HRPT2, CASR, CDKN1B, and AIP genes in primary hyperparathyroidism patients with features of genetic predisposition. (PubMed id 19474519)1, 4, 9 Vierimaa O....Salmela P.I. (J. Endocrinol. Invest. 2009)
    10. The tyrosine kinase receptor RET interacts in vivo with aryl hydrocarbon receptor-interacting protein to alter survivin availability. (PubMed id 19366855)1, 2, 9 Vargiolu M.... Bonora E. (J. Clin. Endocrinol. Metab. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9049 HGNC: 358 AceView: AIP Ensembl:ENSG00000110711 euGenes: HUgn9049
    ECgene: AIP H-InvDB: AIP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AIP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AIP Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=AIP[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AIP gene:
    Search GeneIP for patents involving AIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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