Aliases for AIP Gene
External Ids for AIP Gene
Previous GeneCards Identifiers for AIP Gene
The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
GeneCards Summary for AIP Gene
AIP (Aryl Hydrocarbon Receptor Interacting Protein) is a Protein Coding gene. Diseases associated with AIP include Pituitary Adenoma 1, Multiple Types and Acroleukopathy, Symmetric. Among its related pathways are Aryl Hydrocarbon Receptor and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include transcription factor binding and transcription coactivator activity. An important paralog of this gene is AIPL1.
UniProtKB/Swiss-Prot for AIP Gene
May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
Cellular negative regulator of the hepatitis B virus (HBV) X protein.