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Aliases for AIMP2 Gene

Aliases for AIMP2 Gene

  • Aminoacyl TRNA Synthetase Complex-Interacting Multifunctional Protein 2 2 3 5
  • Multisynthase Complex Auxiliary Component P38 3 4
  • Protein JTV-1 3 4
  • JTV1 3 4
  • Multisynthetase Complex Auxiliary Component P38 3
  • ARS-Interacting Multi-Functional Protein 2 3
  • PRO0992 3
  • JTV-1 3
  • P38 3

External Ids for AIMP2 Gene

Summaries for AIMP2 Gene

Entrez Gene Summary for AIMP2 Gene

  • The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for AIMP2 Gene

AIMP2 (Aminoacyl TRNA Synthetase Complex-Interacting Multifunctional Protein 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism.

UniProtKB/Swiss-Prot for AIMP2 Gene

  • Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.

Gene Wiki entry for AIMP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AIMP2 Gene

Genomics for AIMP2 Gene

Regulatory Elements for AIMP2 Gene

Promoters for AIMP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AIMP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for AIMP2 Gene

Chromosome:
7
Start:
6,009,245 bp from pter
End:
6,023,834 bp from pter
Size:
14,590 bases
Orientation:
Plus strand

Genomic View for AIMP2 Gene

Genes around AIMP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AIMP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AIMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AIMP2 Gene

Proteins for AIMP2 Gene

  • Protein details for AIMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13155-AIMP2_HUMAN
    Recommended name:
    Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Protein Accession:
    Q13155
    Secondary Accessions:
    • Q75MR1
    • Q96CZ5
    • Q9P1L2

    Protein attributes for AIMP2 Gene

    Size:
    320 amino acids
    Molecular mass:
    35349 Da
    Quaternary structure:
    • Component of the aminoacyl-tRNA synthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Binds FUBP1 (via C-terminus). Interacts in both its unphosphorylated and phosphorylated forms with p53/TP53 (via N-terminus) in the nucleus following UV irradiation. Interacts (via N-terminus) with KARS and PARK2/parkin (via first RING-type domain).
    Miscellaneous:
    • Accumulates in brains affected by autosomal-recessive juvenile parkinsonism, idiopathic Parkinson disease and diffuse Lewy body disease.
    SequenceCaution:
    • Sequence=AAC50391.1; Type=Frameshift; Positions=312; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AIMP2 Gene

neXtProt entry for AIMP2 Gene

Proteomics data for AIMP2 Gene at MOPED

Post-translational modifications for AIMP2 Gene

  • Phosphorylated on serine residues in response to UV irradiation.
  • Ubiquitinated by PARK2, leading to its degradation by the proteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.
  • Ubiquitination at Lys 7
  • Modification sites at PhosphoSitePlus

Other Protein References for AIMP2 Gene

Antibody Products

No data available for DME Specific Peptides for AIMP2 Gene

Domains & Families for AIMP2 Gene

Protein Domains for AIMP2 Gene

Suggested Antigen Peptide Sequences for AIMP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13155

UniProtKB/Swiss-Prot:

AIMP2_HUMAN :
  • Contains 1 GST C-terminal domain.
Domain:
  • Contains 1 GST C-terminal domain.
genes like me logo Genes that share domains with AIMP2: view

No data available for Gene Families for AIMP2 Gene

Function for AIMP2 Gene

Molecular function for AIMP2 Gene

UniProtKB/Swiss-Prot Function:
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
genes like me logo Genes that share phenotypes with AIMP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AIMP2

CRISPR Products

miRNA for AIMP2 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AIMP2 Gene

Localization for AIMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AIMP2 Gene

Cytoplasm, cytosol. Nucleus. Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AIMP2 Gene COMPARTMENTS Subcellular localization image for AIMP2 gene
Compartment Confidence
cytosol 5
nucleus 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for AIMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with AIMP2: view

Pathways & Interactions for AIMP2 Gene

genes like me logo Genes that share pathways with AIMP2: view

Pathways by source for AIMP2 Gene

Gene Ontology (GO) - Biological Process for AIMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0031398 positive regulation of protein ubiquitination IEA --
GO:1901216 positive regulation of neuron death IEA --
genes like me logo Genes that share ontologies with AIMP2: view

No data available for SIGNOR curated interactions for AIMP2 Gene

Drugs & Compounds for AIMP2 Gene

No Compound Related Data Available

Transcripts for AIMP2 Gene

Unigene Clusters for AIMP2 Gene

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AIMP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: -

Relevant External Links for AIMP2 Gene

GeneLoc Exon Structure for
AIMP2
ECgene alternative splicing isoforms for
AIMP2

Expression for AIMP2 Gene

mRNA expression in normal human tissues for AIMP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AIMP2 Gene

This gene is overexpressed in Muscle - Skeletal (x6.7).

Protein differential expression in normal tissues from HIPED for AIMP2 Gene

This gene is overexpressed in Breast (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AIMP2 Gene



SOURCE GeneReport for Unigene cluster for AIMP2 Gene Hs.301613

genes like me logo Genes that share expression patterns with AIMP2: view

Protein tissue co-expression partners for AIMP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AIMP2 Gene

Orthologs for AIMP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for AIMP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AIMP2 35
  • 82.5 (n)
  • 82.81 (a)
AIMP2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AIMP2 35
  • 87.71 (n)
  • 90.31 (a)
-- 36
  • 73 (a)
OneToMany
AIMP2 36
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Aimp2 35
  • 83.65 (n)
  • 86.87 (a)
Aimp2 16
Aimp2 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AIMP2 35
  • 98.75 (n)
  • 97.5 (a)
AIMP2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aimp2 35
  • 82.92 (n)
  • 88.12 (a)
oppossum
(Monodelphis domestica)
Mammalia AIMP2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AIMP2 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves AIMP2 35
  • 71.9 (n)
  • 76.79 (a)
AIMP2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AIMP2 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aimp2 35
  • 67.52 (n)
  • 70.74 (a)
Str.1365 35
African clawed frog
(Xenopus laevis)
Amphibia jtv1-prov 35
zebrafish
(Danio rerio)
Actinopterygii aimp2 35
  • 58.41 (n)
  • 57.78 (a)
wufc09d04 35
aimp2 36
  • 55 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9061 35
fruit fly
(Drosophila melanogaster)
Insecta CG12304 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2526 36
  • 30 (a)
OneToOne
Species with no ortholog for AIMP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AIMP2 Gene

ENSEMBL:
Gene Tree for AIMP2 (if available)
TreeFam:
Gene Tree for AIMP2 (if available)

Paralogs for AIMP2 Gene

genes like me logo Genes that share paralogs with AIMP2: view

No data available for Paralogs for AIMP2 Gene

Variants for AIMP2 Gene

Sequence variations from dbSNP and Humsavar for AIMP2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17855441 - 6,017,857(+) CCCGG(C/G)CTCCC reference, missense
rs34525431 - 6,017,967(-) CTTGA(G/T)AAGGT reference, missense
VAR_058392 A lung cancer cell line
VAR_058394 A lung cancer cell line
rs1860459 -- 6,016,988(-) AGTGC(C/T)AGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AIMP2 Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv830894 CNV Loss 17160897
nsv7392 OTHER Inversion 18451855
esv1914954 OTHER Inversion 16254605

Variation tolerance for AIMP2 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AIMP2 Gene

HapMap Linkage Disequilibrium report
AIMP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AIMP2 Gene

Disorders for AIMP2 Gene

Relevant External Links for AIMP2

Human Genome Epidemiology (HuGE) Navigator
AIMP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AIMP2

No disorders were found for AIMP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AIMP2 Gene

Publications for AIMP2 Gene

  1. AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53. (PMID: 18695251) Han J.M. … Kim S. (Proc. Natl. Acad. Sci. U.S.A. 2008) 2 3 4 67
  2. Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. (PMID: 9878398) Quevillon S. … Mirande M. (J. Mol. Biol. 1999) 3 23
  3. Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene. (PMID: 8666379) Nicolaides N.C. … Vogelstein B. (Genomics 1995) 2 3
  4. Interaction of NS2 with AIMP2 facilitates the switch from ubiquitination to SUMOylation of M1 in influenza A virus-infected cells. (PMID: 25320310) Gao S. … Huang W. (J. Virol. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for AIMP2 Gene

Sources for AIMP2 Gene

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