Aliases for AIMP2 Gene
External Ids for AIMP2 Gene
The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown. [provided by RefSeq, Jul 2008]
GeneCards Summary for AIMP2 Gene
AIMP2 (Aminoacyl TRNA Synthetase Complex-Interacting Multifunctional Protein 2) is a Protein Coding gene. Diseases associated with AIMP2 include lung cancer. Among its related pathways are Gene Expression and Osteoclast Signaling.
UniProtKB/Swiss-Prot for AIMP2 Gene
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.