Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



AIMP2 Gene

protein-coding   GIFtS: 58
GCID: GC07P006016

Aminoacyl TRNA Synthetase Complex-Interacting Multifunctional...

  Search for AIMP2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Aminoacyl TRNA Synthetase Complex-Interacting Multifunctional Protein
21 2
     P382
JTV12 3 5     Aminoacyl TRNA Synthase Complex-Interacting Multifunctional Protein 22
Multisynthase Complex Auxiliary Component P382 3     ARS-Interacting Multi-Functional Protein 22
Protein JTV-12 3     Multisynthetase Complex Auxiliary Component P382
JTV-12     

External Ids:    HGNC: 206091   Entrez Gene: 79652   Ensembl: ENSG000001063057   OMIM: 6008595   UniProtKB: Q131553   

Export aliases for AIMP2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for AIMP2 Gene:
The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and
are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are
arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of
the JTV1 gene product is unknown. (provided by RefSeq, Jul 2008)

GeneCards Summary for AIMP2 Gene:
AIMP2 (aminoacyl tRNA synthetase complex-interacting multifunctional protein 2) is a protein-coding gene.

UniProtKB/Swiss-Prot: AIMP2_HUMAN, Q13155
Function: Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and
degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for
aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions
as a proapoptotic factor

Gene Wiki entry for AIMP2 (Multisynthetase complex auxiliary component p38) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for AIMP2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAIMP2 promoter sequence
   Search Chromatin IP Primers for AIMP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AIMP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.1

AIMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AIMP2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P006016:  view genomic region     (about GC identifiers)

Start:
6,048,876 bp from pter      End:
6,063,465 bp from pter
Size:
14,590 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 6,095,227-6,109,810     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AIMP2_HUMAN, Q13155 (See protein sequence)
Recommended Name: Aminoacyl tRNA synthase complex-interacting multifunctional protein 2  
Size: 320 amino acids; 35349 Da
Subunit: Component of the aminoacyl-tRNA synthase complex which is comprised of a bifunctional
glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and
aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Binds FUBP1 (via
C-terminus). Interacts in both its unphosphorylated and phosphorylated forms with p53/TP53 (via N-terminus) in
the nucleus following UV irradiation. Interacts (via N-terminus) with KARS and PARK2/parkin (via first RING-type
domain)
Miscellaneous: Accumulates in brains affected by autosomal-recessive juvenile parkinsonism, idiopathic Parkinson
disease and diffuse Lewy body disease
Sequence caution: Sequence=AAC50391.1; Type=Frameshift; Positions=312;
1 PDB 3D structure from and Proteopedia for AIMP2:
4DPG (3D)    
Secondary accessions: Q75MR1 Q96CZ5 Q9P1L2

Explore the universe of human proteins at neXtProt for AIMP2: NX_Q13155

Explore proteomics data for AIMP2 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine residues in response to UV irradiation (By similarity)1
  • Ubiquitinated by PARK2, leading to its degradation by the proteasome. Mutant PARK2 fails to ubiquitinate AIMP2
    efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson
    disease1
  • Ubiquitination2 at Lys7
  • Modification sites at PhosphoSitePlus

  • See AIMP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006294.2  
    ENSEMBL proteins: 
     ENSP00000223029   ENSP00000383327   ENSP00000392519   ENSP00000378658  
    Reactome Protein details: Q13155

    AIMP2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for AIMP2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for AIMP2
    GenScript Custom Purified and Recombinant Proteins Services for AIMP2
    Novus Biologicals AIMP2 Proteins
    Novus Biologicals AIMP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AIMP2

     
    Search eBioscience for Proteins for AIMP2 

    AIMP2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for AIMP2
    OriGene Custom Antibody Services for AIMP2
    Novus Biologicals AIMP2 Antibodies
    Abcam antibodies for AIMP2
    Cloud-Clone Corp. Antibodies for AIMP2
    ThermoFisher Antibody for AIMP2
    LSBio Antibodies in human, mouse, rat for AIMP2

    AIMP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AIMP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AIMP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AIMP2
    Cloud-Clone Corp. CLIAs for AIMP2
    Search eBioscience for ELISAs for AIMP2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry Q13155

    ProtoNet protein and cluster: Q13155

    UniProtKB/Swiss-Prot: AIMP2_HUMAN, Q13155
    Similarity: Contains 1 GST C-terminal domain


    Find genes that share domains with AIMP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AIMP2_HUMAN, Q13155
    Function: Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and
    degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for
    aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions
    as a proapoptotic factor

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with AIMP2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Aimp2):
     mortality/aging 

    Find genes that share phenotypes with AIMP2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AIMP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AIMP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AIMP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AIMP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target AIMP2:
    hsa-mir-365a-3p (MIRT044033), hsa-mir-193b-3p (MIRT016291), hsa-mir-744-5p (MIRT037437), hsa-mir-34a-5p (MIRT025288)

    Block miRNA regulation of human, mouse, rat AIMP2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate AIMP2
    SwitchGear 3'UTR luciferase reporter plasmidAIMP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AIMP2
    Predesigned siRNA for gene silencing in human, mouse, rat AIMP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AIMP2

    Clone
    Products:
         
    OriGene clones in human, mouse for AIMP2 (see all 7)
    OriGene ORF clones in mouse, rat for AIMP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AIMP2 (NM_006303)
    Sino Biological Human cDNA Clone for AIMP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AIMP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIMP2
    Addgene plasmids for AIMP2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AIMP2
    Browse ESI BIO Cell Lines and PureStem Progenitors for AIMP2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIMP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    AIMP2_HUMAN, Q13155: Cytoplasm, cytosol (By similarity). Nucleus (By similarity). Note=Following DNA damage,
    dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with AIMP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for AIMP2 About    
    See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Cytosolic tRNA aminoacylation0.57
    2Gene Expression
    Gene Expression0.40
    3Osteoclast Signaling
    Osteoclast Signaling
    4Keap1-Nrf2 Pathway
    Keap1-Nrf2 Pathway


    Find genes that share SuperPaths with AIMP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for AIMP2
        Keap1-Nrf2 Pathway
    Osteoclast Signaling


    1 Reactome Pathway for AIMP2
        Cytosolic tRNA aminoacylation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AIMP2
    Interactions:

        GeneGlobe Interaction Network for AIMP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AIMP2 (Q131551, 2, 3 ENSP000002230294) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FUBP1Q96AE41, 2, 3, ENSP000003598044EBI-745226,EBI-711404 MINT-8145530 MINT-8145585 MINT-8145599 I2D: score=3 STRING: ENSP00000359804
    KARSQ150461, 2, 3, ENSP000003254484EBI-745226,EBI-356367 MINT-66634 MINT-8258901 I2D: score=7 STRING: ENSP00000325448
    DARSP148682, 3, ENSP000002641614MINT-8258842 MINT-66813 I2D: score=5 STRING: ENSP00000264161
    QARSP478972, 3, ENSP000003075674MINT-8145506 MINT-8145517 I2D: score=2 STRING: ENSP00000307567
    EPS8Q129292, 3, ENSP000002811724MINT-67317 I2D: score=5 STRING: ENSP00000281172
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006915apoptotic process IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0010467gene expression TAS--
    GO:0031398positive regulation of protein ubiquitination IEA--

    Find genes that share ontologies with AIMP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AIMP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for AIMP2 gene: 
    NM_006303.3  

    Unigene Cluster for AIMP2:

    Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
    Hs.301613  [show with all ESTs]
    Unigene Representative Sequence: BQ065837
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000223029(uc003spo.3) ENST00000400479 ENST00000415999 ENST00000395236

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AIMP2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate AIMP2
    SwitchGear 3'UTR luciferase reporter plasmidAIMP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AIMP2
    Predesigned siRNA for gene silencing in human, mouse, rat AIMP2
    Clone
    Products:
         
    OriGene clones in human, mouse for AIMP2 (see all 7)
    OriGene ORF clones in mouse, rat for AIMP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AIMP2 (NM_006303)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AIMP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIMP2
    Addgene plasmids for AIMP2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AIMP2
    OriGene qSTAR qPCR primer pairs in human, mouse for AIMP2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat AIMP2
      QuantiTect SYBR Green Assays in human, mouse, rat AIMP2
      QuantiFast Probe-based Assays in human, mouse, rat AIMP2

    Additional mRNA sequence: 

    AK313037.1 BC002853.1 BC010156.1 BC013630.1 U24169.1 

    11 DOTS entries:

    DT.100678744  DT.100678754  DT.92466975  DT.100678743  DT.95352077  DT.95367171  DT.211931  DT.121093621 
    DT.121093649  DT.449929  DT.92467022 

    Selected AceView cDNA sequences (see all 600):

    AA307415 BQ430712 BQ214229 BM142543 AA284810 AA583713 CN484916 AA868035 
    F07068 BI256453 BU165745 AA773441 BM908371 BC006524 BU626736 BQ940896 
    AF085994 BX380291 AW615009 AI358265 BU155504 BQ066667 CA433568 AA486430 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for AIMP2    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
    SP1:                                -     -     -     -                                 
    SP2:                          -     -     -     -                                       
    SP3:                                -           -     -                                 
    SP4:                          -     -     -     -     -                                 
    SP5:                                                  -                                 


    ECgene alternative splicing isoforms for AIMP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    AIMP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATTTAAAA
    AIMP2 Expression
    About this image


    AIMP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    AIMP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AIMP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.301613
        Custom PCR Arrays for AIMP2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AIMP2
    OriGene qSTAR qPCR primer pairs in human, mouse for AIMP2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat AIMP2
    QuantiTect SYBR Green Assays in human, mouse, rat AIMP2
    QuantiFast Probe-based Assays in human, mouse, rat AIMP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIMP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for AIMP2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aimp21 , 5 aminoacyl tRNA synthetase complex-interacting multifunctional more1, 5 83.65(n)1
    86.87(a)1
      5 (82.80 cM)5
    2318721  NM_001172146.11  NP_001165617.11 
     1439027045 
    chicken
    (Gallus gallus)
    Aves AIMP21 aminoacyl tRNA synthetase complex-interacting multifunctional more 71.9(n)
    76.79(a)
      769030  XM_001232212.3  XP_001232213.3 
    lizard
    (Anolis carolinensis)
    Reptilia AIMP26
    aminoacyl tRNA synthetase complex-interacting mult...
    63(a)
    1 ↔ 1
    GL343507.1(222032-230316)
    African clawed frog
    (Xenopus laevis)
    Amphibia jtv1-prov2 JTV1 gene 75.19(n)    BC043832.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc09d042 Danio rerio cDNA clone MGC63976 IMAGE6792283, complete more 70.86(n)    BC053178.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG123046
    --
    23(a)
    1 ↔ 1
    3L(15576738-15578447)


    ENSEMBL Gene Tree for AIMP2 (if available)
    TreeFam Gene Tree for AIMP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for AIMP2 gene

    Find genes that share paralogs with AIMP2           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for AIMP2
    PGOHUM00000242860 PGOHUM00000232873 PGOHUM00000233402 PGOHUM00000233430 PGOHUM00000262534


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for AIMP2 (see all 329)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0583924
    A lung cancer cell line4--see VAR_0583922 I V mis40--------
    VAR_0583944
    A lung cancer cell line4--see VAR_0583942 G S mis40--------
    rs1143046611,2
    C,F--6050791(+) TTATAC/TAGAGG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs771992181,2
    C--6050796(+) CAGAGG/TAGCAG 1 -- int13Minor allele frequency- T:0.20NA EA 242
    rs132401381,2
    C,F--6050825(+) TGAATG/AGGACT 1 -- int15Minor allele frequency- A:0.15NA EA 246
    rs1156977521,2
    C,F--6050882(+) CCAAAG/ATTATA 1 -- int11Minor allele frequency- A:0.03WA 118
    rs752852431,2
    C--6050909(+) CTCACC/AGCTCA 1 -- int12Minor allele frequency- A:0.04NA 122
    rs1840118751,2
    --6050990(+) GGTAGG/TTTTAG 1 -- int10--------
    rs624561841,2
    C,F--6051110(+) CAAACG/ATACAT 1 -- int12Minor allele frequency- A:0.50NA WA 4
    rs1885596301,2
    --6051162(+) CACAAG/TATGGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for AIMP2 (6048876 - 6063465 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for AIMP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436904CNV Insertion17901297
    nsv830894CNV Loss17160897
    esv1914954OTHER Inversion16254605
    nsv7392OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AIMP2
    DNA2.0 Custom Variant and Variant Library Synthesis for AIMP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600859    OMIM disorders: --


    Find genes that share disorders with AIMP2           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: AIMP2 (5 documents)

    Export disorders for AIMP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for AIMP2 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with AIMP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53. (PubMed id 18695251)1, 2, 3 Han J.M.... Kim S. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    2. Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene. (PubMed id 8666379)1, 2, 3 Nicolaides N.C.... Vogelstein B. (Genomics 1995)
    3. Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. (PubMed id 9878398)1, 2, 9 Quevillon S.... Mirande M. (J. Mol. Biol. 1999)
    4. Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. (PubMed id 16135753)1, 2 Ko H.S.... Dawson T.M. (J. Neurosci. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    8. Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation. (PubMed id 12819782)1, 2 Kim M.J.... Kim S. (Nat. Genet. 2003)
    9. Chemical suppression of an oncogenic splicing variant of AIMP2 induces tumour regression. (PubMed id 23815603)1 Lee H.S....Kim S. (Biochem. J. 2013)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7965 HGNC: 20609 AceView: HRI Ensembl:ENSG00000106305 euGenes: HUgn7965
    ECgene: AIMP2 H-InvDB: AIMP2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for AIMP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AIMP2 gene:
    Search GeneIP for patents involving AIMP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for AIMP2   OriGene RNAi products in human, mouse, rat for AIMP2  
     OriGene qPCR primer pairs and template standards for AIMP2   OriGene Protein Over-expression Lysate for AIMP2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for AIMP2  
     OriGene qSTAR qPCR primer pairs in human, mouse for AIMP2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for AIMP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AIMP2   OriGene Custom Protein Services for AIMP2  

     
     
     Block miRNA regulation of human, mouse, rat AIMP2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AIMP2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AIMP2 Predesigned siRNA for gene silencing in human, mouse, rat AIMP2
     QuantiFast Probe-based Assays in human, mouse, rat AIMP2 QuantiTect SYBR Green Assays in human, mouse, rat AIMP2
     Custom PCR Arrays for AIMP2 Search Chromatin IP Primers for AIMP2
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat AIMP2  GeneGlobe Interaction Network for AIMP2
     Search Regulatory tfbs for AIMP2
     GenScript Custom Purified and Recombinant Proteins Services for AIMP2 GenScript cDNA clones with any tag delivered in your preferred vector for AIMP2
     GenScript Custom Assay Services for AIMP2 GenScript Custom overexpressing Cell Line Services for AIMP2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for AIMP2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for AIMP2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     AIMP2 antibodies
     AIMP2 proteins
     AIMP2 lysates
     Antibodies for AIMP2
     See all of Abcam's Antibodies, Kits and Proteins for AIMP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for AIMP2
     Antibodies for AIMP2
     ELISAs for AIMP2
     CLIAs for AIMP2



     Browse ESI BIO Cell Lines and PureStem Progenitors for AIMP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIMP2
     SwitchGear 3'UTR luciferase reporter plasmids for AIMP2
     SwitchGear Promoter luciferase reporter plasmids for AIMP2
     ThermoFisher Antibody for AIMP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIMP2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AIMP2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AIMP2
     LSBio Antibodies in human, mouse, rat for AIMP2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for AIMP2
      Search eBioscience for proteins for AIMP2
      Search eBioscience for elisas for AIMP2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AIMP2 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4