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Aliases for AIMP2 Gene

Aliases for AIMP2 Gene

  • Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2 2 3 5
  • Multisynthase Complex Auxiliary Component P38 3 4
  • Protein JTV-1 3 4
  • JTV1 3 4
  • Aminoacyl TRNA Synthase Complex-Interacting Multifunctional Protein 2 3
  • Multisynthetase Complex Auxiliary Component P38 3
  • ARS-Interacting Multi-Functional Protein 2 3
  • JTV-1 3
  • P38 3

External Ids for AIMP2 Gene

Summaries for AIMP2 Gene

Entrez Gene Summary for AIMP2 Gene

  • The protein encoded by this gene is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the complex. [provided by RefSeq, May 2016]

GeneCards Summary for AIMP2 Gene

AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Gene Expression.

UniProtKB/Swiss-Prot for AIMP2 Gene

  • Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.

Gene Wiki entry for AIMP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AIMP2 Gene

Genomics for AIMP2 Gene

Regulatory Elements for AIMP2 Gene

Enhancers for AIMP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G005454 1 dbSUPER 5.5 -553.7 -553740 2.6 ATF1 CREB3L1 ARID4B SIN3A ZNF48 ZNF2 ZNF143 ZNF207 KLF7 ZNF263 FBXL18 AIMP2 GC07P005444 ENSG00000230733
GH07G005591 1.8 FANTOM5 ENCODE dbSUPER 1.3 -413.8 -413793 8.6 HDGF PKNOX1 ARNT CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 C7orf26 AP5Z1 CCZ1 USP42 FSCN1 ACTB FBXL18 AIMP2 RNF216-IT1
GH07G006854 0.4 Ensembl 4.5 +845.9 845927 2.1 ZNF366 ZNF512 CCZ1B CCZ1 AIMP2 UNC93B2 PIR56080
GH07G006007 1.2 ENCODE 0.7 +1.4 1382 6.3 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A RCOR2 EIF2AK1 PMS2 PMS2CL CCZ1 RSPH10B ZDHHC4 AIMP2 ENSG00000207217
GH07G006014 1.3 Ensembl ENCODE 0.4 +7.1 7149 3.1 FOXA2 PKNOX1 ARNT SIN3A ARID4B DMAP1 ZNF766 FOS KLF13 JUNB EIF2AK1 PMS2 PMS2CL ENSG00000198580 CCZ1 RSPH10B ZDHHC4 ENSG00000207217 AIMP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AIMP2 on UCSC Golden Path with GeneCards custom track

Promoters for AIMP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000208164 -45 2001 PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for AIMP2 Gene

Chromosome:
7
Start:
6,009,245 bp from pter
End:
6,023,834 bp from pter
Size:
14,590 bases
Orientation:
Plus strand

Genomic View for AIMP2 Gene

Genes around AIMP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AIMP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AIMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AIMP2 Gene

Proteins for AIMP2 Gene

  • Protein details for AIMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13155-AIMP2_HUMAN
    Recommended name:
    Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Protein Accession:
    Q13155
    Secondary Accessions:
    • Q75MR1
    • Q96CZ5
    • Q9P1L2

    Protein attributes for AIMP2 Gene

    Size:
    320 amino acids
    Molecular mass:
    35349 Da
    Quaternary structure:
    • Component of the aminoacyl-tRNA synthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Binds FUBP1 (via C-terminus). Interacts in both its unphosphorylated and phosphorylated forms with p53/TP53 (via N-terminus) in the nucleus following UV irradiation. Interacts (via N-terminus) with KARS and PARK2/parkin (via first RING-type domain).
    Miscellaneous:
    • Accumulates in brains affected by autosomal-recessive juvenile parkinsonism, idiopathic Parkinson disease and diffuse Lewy body disease.
    SequenceCaution:
    • Sequence=AAC50391.1; Type=Frameshift; Positions=312; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AIMP2 Gene

neXtProt entry for AIMP2 Gene

Post-translational modifications for AIMP2 Gene

  • Phosphorylated on serine residues in response to UV irradiation.
  • Ubiquitinated by PARK2, leading to its degradation by the proteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.
  • Ubiquitination at Lys7
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for AIMP2 Gene

Domains & Families for AIMP2 Gene

Protein Domains for AIMP2 Gene

Suggested Antigen Peptide Sequences for AIMP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AIMP2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for AIMP2 Gene

Function for AIMP2 Gene

Molecular function for AIMP2 Gene

UniProtKB/Swiss-Prot Function:
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.

Gene Ontology (GO) - Molecular Function for AIMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0032947 protein complex scaffold IEA --
genes like me logo Genes that share ontologies with AIMP2: view
genes like me logo Genes that share phenotypes with AIMP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AIMP2

CRISPR Products

miRNA for AIMP2 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for AIMP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AIMP2 Gene

Localization for AIMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AIMP2 Gene

Cytoplasm, cytosol. Nucleus. Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AIMP2 gene
Compartment Confidence
cytosol 5
nucleus 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for AIMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex IEA --
genes like me logo Genes that share ontologies with AIMP2: view

Pathways & Interactions for AIMP2 Gene

genes like me logo Genes that share pathways with AIMP2: view

Gene Ontology (GO) - Biological Process for AIMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006461 protein complex assembly IEA --
GO:0006915 apoptotic process IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with AIMP2: view

No data available for SIGNOR curated interactions for AIMP2 Gene

Drugs & Compounds for AIMP2 Gene

No Compound Related Data Available

Transcripts for AIMP2 Gene

Unigene Clusters for AIMP2 Gene

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for AIMP2

Alternative Splicing Database (ASD) splice patterns (SP) for AIMP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: -

Relevant External Links for AIMP2 Gene

GeneLoc Exon Structure for
AIMP2
ECgene alternative splicing isoforms for
AIMP2

Expression for AIMP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AIMP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AIMP2 Gene

This gene is overexpressed in Muscle - Skeletal (x6.7).

Protein differential expression in normal tissues from HIPED for AIMP2 Gene

This gene is overexpressed in Breast (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AIMP2 Gene



Protein tissue co-expression partners for AIMP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AIMP2 Gene:

AIMP2

SOURCE GeneReport for Unigene cluster for AIMP2 Gene:

Hs.301613

Evidence on tissue expression from TISSUES for AIMP2 Gene

  • Liver(4.2)
  • Nervous system(2.7)
  • Intestine(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with AIMP2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AIMP2 Gene

Orthologs for AIMP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for AIMP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AIMP2 34 35
  • 98.75 (n)
dog
(Canis familiaris)
Mammalia AIMP2 34 35
  • 87.71 (n)
-- 35
  • 73 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Aimp2 34 16 35
  • 83.65 (n)
rat
(Rattus norvegicus)
Mammalia Aimp2 34
  • 82.92 (n)
cow
(Bos Taurus)
Mammalia AIMP2 34 35
  • 82.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AIMP2 35
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AIMP2 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves AIMP2 34 35
  • 71.9 (n)
lizard
(Anolis carolinensis)
Reptilia AIMP2 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aimp2 34
  • 67.52 (n)
Str.1365 34
African clawed frog
(Xenopus laevis)
Amphibia jtv1-prov 34
zebrafish
(Danio rerio)
Actinopterygii aimp2 34 35
  • 58.41 (n)
wufc09d04 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9061 34
fruit fly
(Drosophila melanogaster)
Insecta CG12304 35
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2526 35
  • 30 (a)
OneToOne
Species where no ortholog for AIMP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AIMP2 Gene

ENSEMBL:
Gene Tree for AIMP2 (if available)
TreeFam:
Gene Tree for AIMP2 (if available)

Paralogs for AIMP2 Gene

genes like me logo Genes that share paralogs with AIMP2: view

No data available for Paralogs for AIMP2 Gene

Variants for AIMP2 Gene

Sequence variations from dbSNP and Humsavar for AIMP2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_058392 A lung cancer cell line
VAR_058394 A lung cancer cell line
rs587779333 Pathogenic 6,009,019(-) CATCC(A/G/T)TGGAG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs587780059 Pathogenic 6,009,018(-) ATCCA(A/C/G/T)GGAGC nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs763939668 Pathogenic 6,009,013(+) AGCTC(A/C/G)CTCCA nc-transcript-variant, upstream-variant-2KB, reference, missense, stop-gained, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for AIMP2 Gene

Variant ID Type Subtype PubMed ID
dgv6241n100 CNV gain 25217958
esv1914954 OTHER inversion 16254605
esv3541116 CNV deletion 23714750
esv3612008 CNV loss 21293372
esv3612009 CNV gain 21293372
esv3891031 CNV loss 25118596
nsv1018388 CNV gain 25217958
nsv1034916 CNV gain 25217958
nsv436904 CNV insertion 17901297
nsv605998 CNV loss 21841781
nsv7392 OTHER inversion 18451855
nsv830894 CNV loss 17160897

Variation tolerance for AIMP2 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AIMP2 Gene

Human Gene Mutation Database (HGMD)
AIMP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AIMP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AIMP2 Gene

Disorders for AIMP2 Gene

Relevant External Links for AIMP2

Human Genome Epidemiology (HuGE) Navigator
AIMP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AIMP2

No disorders were found for AIMP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AIMP2 Gene

Publications for AIMP2 Gene

  1. AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53. (PMID: 18695251) Han J.M. … Kim S. (Proc. Natl. Acad. Sci. U.S.A. 2008) 2 3 4 64
  2. Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. (PMID: 9878398) Quevillon S. … Mirande M. (J. Mol. Biol. 1999) 3 4 22 64
  3. Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene. (PMID: 8666379) Nicolaides N.C. … Vogelstein B. (Genomics 1995) 2 3 4 64
  4. Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. (PMID: 16135753) Ko H.S. … Dawson T.M. (J. Neurosci. 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for AIMP2 Gene

  • Addgene plasmids for AIMP2

Sources for AIMP2 Gene

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