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Aliases for AIMP2 Gene

Aliases for AIMP2 Gene

  • Aminoacyl TRNA Synthetase Complex-Interacting Multifunctional Protein 2 2 3
  • JTV1 3 4 6
  • Multisynthase Complex Auxiliary Component P38 3 4
  • Protein JTV-1 3 4
  • Aminoacyl TRNA Synthase Complex-Interacting Multifunctional Protein 2 3
  • Multisynthetase Complex Auxiliary Component P38 3
  • ARS-Interacting Multi-Functional Protein 2 3
  • PRO0992 3
  • JTV-1 3
  • P38 3

External Ids for AIMP2 Gene

Summaries for AIMP2 Gene

Entrez Gene Summary for AIMP2 Gene

  • The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for AIMP2 Gene

AIMP2 (Aminoacyl TRNA Synthetase Complex-Interacting Multifunctional Protein 2) is a Protein Coding gene. Diseases associated with AIMP2 include lung cancer. Among its related pathways are Gene Expression and Osteoclast Signaling.

UniProtKB/Swiss-Prot for AIMP2 Gene

  • Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.

Gene Wiki entry for AIMP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AIMP2 Gene

Genomics for AIMP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AIMP2 Gene

Start:
6,009,245 bp from pter
End:
6,023,834 bp from pter
Size:
14,590 bases
Orientation:
Plus strand

Genomic View for AIMP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AIMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AIMP2 Gene

No data available for Regulatory Elements for AIMP2 Gene

Proteins for AIMP2 Gene

  • Protein details for AIMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13155-AIMP2_HUMAN
    Recommended name:
    Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Protein Accession:
    Q13155
    Secondary Accessions:
    • Q75MR1
    • Q96CZ5
    • Q9P1L2

    Protein attributes for AIMP2 Gene

    Size:
    320 amino acids
    Molecular mass:
    35349 Da
    Quaternary structure:
    • Component of the aminoacyl-tRNA synthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Binds FUBP1 (via C-terminus). Interacts in both its unphosphorylated and phosphorylated forms with p53/TP53 (via N-terminus) in the nucleus following UV irradiation. Interacts (via N-terminus) with KARS and PARK2/parkin (via first RING-type domain).
    Miscellaneous:
    • Accumulates in brains affected by autosomal-recessive juvenile parkinsonism, idiopathic Parkinson disease and diffuse Lewy body disease
    SequenceCaution:
    • Sequence=AAC50391.1; Type=Frameshift; Positions=312; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AIMP2 Gene

neXtProt entry for AIMP2 Gene

Proteomics data for AIMP2 Gene at MOPED

Post-translational modifications for AIMP2 Gene

  • Phosphorylated on serine residues in response to UV irradiation.
  • Ubiquitinated by PARK2, leading to its degradation by the proteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.
  • Ubiquitination at Lys7
  • Modification sites at PhosphoSitePlus

Other Protein References for AIMP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for AIMP2 Gene

Domains for AIMP2 Gene

Protein Domains for AIMP2 Gene

Suggested Antigen Peptide Sequences for AIMP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13155

UniProtKB/Swiss-Prot:

AIMP2_HUMAN :
  • Q13155
Domain:
  • Contains 1 GST C-terminal domain.
genes like me logo Genes that share domains with AIMP2: view

No data available for Gene Families for AIMP2 Gene

Function for AIMP2 Gene

Molecular function for AIMP2 Gene

UniProtKB/Swiss-Prot Function: Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.

Gene Ontology (GO) - Molecular Function for AIMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with AIMP2: view

Phenotypes for AIMP2 Gene

MGI mutant phenotypes for AIMP2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with AIMP2: view

Animal Model Products

CRISPR Products

miRNA for AIMP2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AIMP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for AIMP2 Gene

Localization for AIMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AIMP2 Gene

Cytoplasm, cytosol. Nucleus. Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AIMP2 Gene COMPARTMENTS Subcellular localization image for AIMP2 gene
Compartment Confidence
cytosol 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for AIMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with AIMP2: view

Pathways for AIMP2 Gene

genes like me logo Genes that share pathways with AIMP2: view

Pathways by source for AIMP2 Gene

2 BioSystems pathways for AIMP2 Gene

Gene Ontology (GO) - Biological Process for AIMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006915 apoptotic process IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0010467 gene expression TAS --
GO:0031398 positive regulation of protein ubiquitination IEA --
genes like me logo Genes that share ontologies with AIMP2: view

Transcripts for AIMP2 Gene

Unigene Clusters for AIMP2 Gene

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AIMP2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AIMP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: -

Relevant External Links for AIMP2 Gene

GeneLoc Exon Structure for
AIMP2
ECgene alternative splicing isoforms for
AIMP2

Expression for AIMP2 Gene

mRNA expression in normal human tissues for AIMP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AIMP2 Gene

This gene is overexpressed in Muscle - Skeletal (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AIMP2 Gene

SOURCE GeneReport for Unigene cluster for AIMP2 Gene Hs.301613

genes like me logo Genes that share expressions with AIMP2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AIMP2 Gene

Orthologs for AIMP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for AIMP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AIMP2 35
  • 98.75 (n)
  • 97.5 (a)
AIMP2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AIMP2 35
  • 82.5 (n)
  • 82.81 (a)
AIMP2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 73 (a)
OneToMany
AIMP2 35
  • 87.71 (n)
  • 90.31 (a)
AIMP2 36
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Aimp2 35
  • 83.65 (n)
  • 86.87 (a)
Aimp2 16
Aimp2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AIMP2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AIMP2 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aimp2 35
  • 82.92 (n)
  • 88.12 (a)
chicken
(Gallus gallus)
Aves AIMP2 35
  • 71.9 (n)
  • 76.79 (a)
AIMP2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AIMP2 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia jtv1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia aimp2 35
  • 67.52 (n)
  • 70.74 (a)
Str.1365 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9061 35
zebrafish
(Danio rerio)
Actinopterygii aimp2 35
  • 58.41 (n)
  • 57.78 (a)
aimp2 36
  • 55 (a)
OneToOne
wufc09d04 35
fruit fly
(Drosophila melanogaster)
Insecta CG12304 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2526 36
  • 30 (a)
OneToOne
Species with no ortholog for AIMP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AIMP2 Gene

ENSEMBL:
Gene Tree for AIMP2 (if available)
TreeFam:
Gene Tree for AIMP2 (if available)

Paralogs for AIMP2 Gene

genes like me logo Genes that share paralogs with AIMP2: view

No data available for Paralogs for AIMP2 Gene

Variants for AIMP2 Gene

Sequence variations from dbSNP and Humsavar for AIMP2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1860459 -- 6,016,988(-) AGTGC(C/T)AGTGG intron-variant
rs1860460 -- 6,013,655(-) CCATT(C/T)TTCAC intron-variant
rs1860461 -- 6,013,633(-) CACCT(C/T)GCACC intron-variant
rs1986625 -- 6,012,797(+) TCCAC(C/T)CGCCT intron-variant, utr-variant-5-prime
rs2009115 -- 6,012,925(+) CTGAC(A/G)TTTGA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for AIMP2 Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv830894 CNV Loss 17160897
nsv7392 OTHER Inversion 18451855
esv1914954 OTHER Inversion 16254605

Relevant External Links for AIMP2 Gene

HapMap Linkage Disequilibrium report
AIMP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AIMP2 Gene

Disorders for AIMP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for AIMP2 Gene including...

Search for AIMP2 Gene in MalaCards »

Relevant External Links for AIMP2

Human Genome Epidemiology (HuGE) Navigator
AIMP2
genes like me logo Genes that share disorders with AIMP2: view

No data available for UniProtKB/Swiss-Prot for AIMP2 Gene

Publications for AIMP2 Gene

  1. AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53. (PMID: 18695251) Han J.M. … Kim S. (Proc. Natl. Acad. Sci. U.S.A. 2008) 2 3 4
  2. Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. (PMID: 9878398) Quevillon S. … Mirande M. (J. Mol. Biol. 1999) 3 4 23
  3. Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene. (PMID: 8666379) Nicolaides N.C. … Vogelstein B. (Genomics 1995) 2 3 4
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  5. Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation. (PMID: 12819782) Kim M.J. … Kim S. (Nat. Genet. 2003) 3 4

Products for AIMP2 Gene

  • Addgene plasmids for AIMP2

Sources for AIMP2 Gene

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