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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AIMP1 Gene

protein-coding   GIFtS: 55
GCID: GC04P107236

aminoacyl tRNA synthetase complex-interacting multifunctional...

(Previous names: small inducible cytokine subfamily E, member 1 (endothelial...)
(Previous symbol: SCYE1)
 Explore 33 diseases affiliated with
AIMP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AIMP1    

Aliases
for AIMP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Aminoacyl TRNA Synthetase Complex-Interacting Multifunctional Protein 11 2     EMAP-21
SCYE11 2 3 5     HLD32
EMAPII1 2 5     Aminoacyl TRNA Synthase Complex-Interacting Multifunctional Protein 12
EMAP22 3 5     ARS-Interacting Multifunctional Protein 12
P431     Endothelial Monocyte-Activating Polypeptide 22
Small Inducible Cytokine Subfamily E, Member 1 (Endothelial
Monocyte-Activating)1 2
     Endothelial-Monocyte Activating Polypeptide II2
Multisynthase Complex Auxiliary Component P432 3     Multisynthetase Complex Auxiliary Component P432

External Ids:    HGNC: 106481   Entrez Gene: 92552   Ensembl: ENSG000001640227   OMIM: 6036055   UniProtKB: Q129043   

Export aliases for AIMP1 gene to outside databases

Previous GC identifers: GC04P107458 GC04P102971


Summaries
for AIMP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AIMP1:
The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the
control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated
vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is
associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in
normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in
tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has
been identified on chromosome 20. (provided by RefSeq, Dec 2008)

UniProtKB/Swiss-Prot: AIMP1_HUMAN, Q12904
Function: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic
arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling
through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in
glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast
proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum.
Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell
apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates
endothelial cell responses by degrading HIF-1A through interaction with PSMA7

Gene Wiki entry for AIMP1 (SCYE1)


Genomic Views
for AIMP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for AIMP1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AIMP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AIMP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AIMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q24

AIMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AIMP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P107236:  view genomic region     (about GC identifiers)

Start:
 107,236,701 bp from pter      End:
 107,270,383 bp from pter
Size:
 33,683 bases      Orientation:
 plus strand

Proteins
for AIMP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AIMP1_HUMAN, Q12904 (See protein sequence)
Recommended Name: Aminoacyl tRNA synthase complex-interacting multifunctional protein 1  
Size: 312 amino acids; 34353 Da
Subunit: Homodimer. Component of the multisynthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA
synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and
three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Interacts (via N-terminus) with RARS (via N-terminus).
Interacts (via C-terminus) with SMURF2. Interacts (via N-terminus) with HSP90B1/gp96 (via C-terminus). Interacts with
PSMA7
Subcellular location: Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle, secretory vesicle (By similarity). Secreted (By
similarity). Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity). Note=Enriched in secretory
vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity).
Also secreted in response to hypoxia and both apoptotic and necrotic cell death
3 PDB 3D structures from and Proteopedia for AIMP1:
1E7Z (3D)        1EUJ (3D)        1FL0 (3D)    
Secondary accessions: B3KTR2 B4E1S7 Q6FG28 Q96CQ9
Alternative splicing: 2 isoforms:  Q12904-1   Q12904-2   

Explore the universe of human proteins at neXtProt for AIMP1: NX_Q12904

Post-translational modifications:

  • Cleaved by caspase-7 in response to apoptosis to produce EMAP-II1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q12904

    • AIMP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001135887.1  NP_001135888.1  NP_004748.2  

    ENSEMBL proteins: 
     ENSP00000423681   ENSP00000350699   ENSP00000378191   ENSP00000405248  
    Reactome Protein details: Q12904
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: AIMP1
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    Novus Biologicals AIMP1 Proteins
    Sino Biological Recombinant Protein for AIMP1
    ProSpec Recombinant Protein for AIMP1
    Uscn Proteins for AIMP1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0005829cytosol TAS--


    AIMP1 for ontologies           About GeneDecksing



    AIMP1 Antibody Products: 
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    Uscn ELISAs and CLIAs for AIMP1

    Protein Domains /
    Families
    for AIMP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AIMP1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR012340 NA-bd_OB-fold
     IPR002547 tRNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q12904

    ProtoNet protein and cluster: Q12904

    UniProtKB/Swiss-Prot: AIMP1_HUMAN, Q12904
    Similarity: Contains 1 tRNA-binding domain


    Function
    for AIMP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AIMP1_HUMAN, Q12904
    Function: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic
    arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling
    through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in
    glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast
    proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum.
    Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell
    apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates
    endothelial cell responses by degrading HIF-1A through interaction with PSMA7

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AIMP1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate AIMP1 (see all 10):
    hsa-miR-3140-3p hsa-miR-101* hsa-miR-340 hsa-miR-1248 hsa-miR-338-5p hsa-miR-514 hsa-miR-3662 hsa-miR-514b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: AIMP1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AIMP1 (see all 4)
    OriGene shRNA RFP: AIMP1
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AIMP1 (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): AIMP1 (NM_004757)
    Sino Biological Human cDNA Clone for AIMP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AIMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIMP1 

    Cell Line
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    Search LifeMap BioReagents cell lines for AIMP1

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IDA11306575
    GO:0005125cytokine activity ISS11306575
    GO:0005515protein binding IPI--
    GO:0042803protein homodimerization activity IDA11306575
    GO:0043498cell surface binding IDA11741979


    AIMP1 for ontologies           About GeneDecksing


    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Aimp1):
     homeostasis/metabolism  immune system 

    AIMP1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for AIMP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1tRNA Aminoacylation
    		tRNA Aminoacylation1.00
    		Cytosolic tRNA aminoacylation0.57
    2Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for AIMP1
        Cytosolic tRNA aminoacylation
    tRNA Aminoacylation
    Gene Expression



    AIMP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AIMP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/71 Interacting proteins for AIMP1 (Q129041, 3 ENSP000003781914) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP5A1P257053, ENSP000002820504I2D: score=2 STRING: ENSP00000282050
    KARSQ150463, ENSP000003254484I2D: score=1 STRING: ENSP00000325448
    RARSP541363, ENSP000002315724I2D: score=4 STRING: ENSP00000231572
    IQGAP1P469403, ENSP000002681824I2D: score=1 STRING: ENSP00000268182
    AIMP2Q131553, ENSP000002230294I2D: score=2 STRING: ENSP00000223029
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001937negative regulation of endothelial cell proliferation IDA11741979
    GO:0006006glucose metabolic process IEA--
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006915apoptotic process IEA--


    AIMP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AIMP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AIMP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AIMP1
    4 Novoseek chemical compound relationships for AIMP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aminoacyl-trna 78.3 9 11818442 (2), 12543078 (2), 16169847 (1), 15627054 (1) (see all 7)
    trna 62.4 8 11292833 (1), 16945568 (1), 19775078 (1), 10801842 (1) (see all 5)
    rapamycin 32.2 12 18029408 (8), 15044617 (3)
    atp 0 1 15710745 (1)

    Search CenterWatch for drugs/clinical trials and news about AIMP1 

    Transcripts
    for AIMP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AIMP1 gene (3 alternative transcripts): 
    NM_001142415.1  NM_001142416.1  NM_004757.3  

    Unigene Cluster for AIMP1:

    Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
    Hs.591680  [show with all ESTs]
    Unigene Representative Sequence: NM_004757
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510207 ENST00000358008 ENST00000394701(uc003hyg.3 uc003hyh.3)
    ENST00000442366(uc011cfg.2)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AIMP1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate AIMP1 (see all 10):
    hsa-miR-3140-3p hsa-miR-101* hsa-miR-340 hsa-miR-1248 hsa-miR-338-5p hsa-miR-514 hsa-miR-3662 hsa-miR-514b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: AIMP1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AIMP1 (see all 4)
    OriGene shRNA RFP: AIMP1
    OriGene siRNA: AIMP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AIMP1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): AIMP1 (NM_004757)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AIMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIMP1 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AIMP1

    Additional cDNA sequence: 

    AK095951.1 AK297950.1 AK303965.1 BC014051.2 CR542281.1 U10117.1 

    16 DOTS entries:

    DT.95130846  DT.100041912  DT.316751  DT.91978020  DT.310987  DT.121258679  DT.92389212  DT.97864692 
    DT.121258669  DT.121258672  DT.97863146  DT.87014099  DT.95225503  DT.100667687  DT.121258696  DT.414340 

    24/308 AceView cDNA sequences (see all 308):

    AU132717 NM_004757 CR602436 CA487163 AA455165 AI479525 AA828405 AA503544 
    AA566076 BE538179 W57697 AA485242 BF436271 U10117 BQ014955 BU625554 
    CD619284 AI458348 CR604744 CB242243 CD619292 AA204880 BM973427 BG677406 

    GeneLoc Exon Structure


    Expression
    for AIMP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AIMP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCAACAGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See AIMP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AIMP1

    SOURCE GeneReport for Unigene cluster: Hs.591680
        SABiosciences Expression via Pathway-Focused PCR Arrays including AIMP1: 
              Inflammatory Cytokines & Receptors in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIMP1

    Orthologs
    for AIMP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for AIMP1 gene from 9/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Aimp11 , 5 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 less1, 5 84.38(n)1
    85.85(a)1    		   3 (61.48 cM)5
    137221  NM_007926.21  NP_031952.21 
     1326604985 
    chicken
    (Gallus gallus)    		 Aves AIMP11 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 less 78.55(n)
    79.81(a)    		   422533  XM_420496.3  XP_420496.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 82(a)
    		 1 ↔ 1
    		 GL343384.1(946699-962572)
    African clawed frog
    (Xenopus laevis)    		 Amphibia scye1-prov2 small inducible cytokine subfamily E, member 1 76.62(n)    BC046580.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufa95a052 Transcribed sequence with moderate similarity to protein pirB55053 (H.sapiens) B55053 endothelial monocyte-activating protein II precursor - human less 76.03(n)    AL912984.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG82351 CG8235 50.22(n)
    46.05(a)    		   35892  NM_136582.3  NP_610426.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G599806
    AT2G406606
    		 Nucleic acid-binding, OB-fold-like protein
    OB-fold nucleic acid binding domain-containing pro...
    		 29(a)
    24(a)
    		 possible ortholog
    1 ↔ 1
    		 3(22154244-22155641)
    2(16965933-16969035)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 methionyl-tRNA synthetase, putative, expressed
    		 31(a)
    23(a)
    		 possible ortholog
    1 ↔ 1
    		 4(13598671-13601147)
    1(35068203-35073448)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria ygjH6
    		 conserved tRNA binding protein
    		 34(a)
    		 1 ↔ 1
    		 Chromosome(3218937-3219269)


    ENSEMBL Gene Tree for AIMP1 (if available)
    TreeFam Gene Tree for AIMP1 (if available) 

    Paralogs
    for AIMP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AIMP1 gene

    AIMP1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for AIMP1
    PGOHUM00000244338 PGOHUM00000247596


    Genomic Variants
    for AIMP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for AIMP1
         1 CNV: 34436
    Human Gene Mutation Database (HGMD): AIMP1
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AIMP1
    DNA2.0 Custom Variant and Variant Library Synthesis for AIMP1

    Disorders / Diseases
    for AIMP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AIMP1 for disorders           About GeneDecksing

    OMIM gene information: 603605    OMIM disorders: --

    UniProtKB/Swiss-Prot: AIMP1_HUMAN, Q12904
  • Defects in AIMP1 are the cause of leukodystrophy hypomyelinating type 3 (HLD3) [MIM:260600]. A severe
    • autosomal recessive hypomyelinating leukodystrophy characterized by early infantile onset of global developmental
    delay, lack of development, lack of speech acquisition, and peripheral spasticity associated with decreased
    myelination in the central nervous system

    20/33 diseases for AIMP1 (see all 33):    About MalaCards
    pelizaeus-merzbacher-like disease    spinal cord injury    pelizaeus-merzbacher disease    traumatic brain injury
    soft tissue sarcoma    type 1 diabetes mellitus    brain injury    diabetes mellitus
    alcohol dependence    appendicitis    fibrosarcoma    leukodystrophy
    neuritis    keratitis    emphysema    sarcoma
    colorectal cancer    vaccinia    spasticity    prostate adenocarcinoma

    9 Novoseek disease relationships for AIMP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 36.9 11 10880244 (2), 11292833 (1), 18281491 (1), 14982944 (1) (see all 8)
    neovascularization 33.8 2 19565673 (1), 11549594 (1)
    fibrosarcoma 30.2 1 11527006 (1)
    tumors 26.1 47 12374666 (4), 11527006 (4), 10873516 (4), 14688335 (3) (see all 15)
    melanoma 25.1 15 16615114 (5), 10493523 (3), 10873516 (2), 18281491 (1) (see all 5)
    sarcoma 23.5 2 12374666 (1), 16615114 (1)
    inflammation 19.6 7 20469692 (2), 15627054 (1), 11001545 (1), 11527006 (1) (see all 5)
    colorectal cancer 10.9 2 14688335 (1), 14982944 (1)
    cancer 2.98 2 16945568 (1), 11527006 (1)

    Human Genome Epidemiology (HuGE) Navigator: AIMP1 (1 document)

    Export disorders for AIMP1 gene to outside databases

    Publications
    for AIMP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AIMP1 gene, integrated from 9 sources (see all 107):
    (articles sorted by number of sources associating them with AIMP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a novel tumor-derived cytokine. Endothelial- monocyte activating polypeptide II. (PubMed id 7929199)1, 2, 3 Kao J.... Stern D.M. (1994)
    2. Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome. (PubMed id 19362550)1, 2, 9 Tandle A.T....Libutti S.K. (2009)
    3. Proteasomes and RARS modulate AIMP1/EMAP II secretion in human cancer cell lines. (PubMed id 17443684)1, 2, 9 Bottoni A....Uberti E.C. (2007)
    4. Pelizaeus-Merzbacher-like disease caused by AIMP1/p43 homozygous mutation. (PubMed id 21092922)1, 2 Feinstein M....Birk O.S. (2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Isolation and characterization of human nuclear and cytosolic multisynthetase complexes and the intracellular distribution of p43/EMAPII. (PubMed id 14500886)1, 2 Wolfe C.L.... Norcum M.T. (2003)
    8. Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry. (PubMed id 11157763)1, 2 Renault L.... Cherfils J. (2001)
    9. The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component. (PubMed id 11306575)1, 2 Shalak V....Mirande M. (2001)
    10. A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases. (PubMed id 10852899)1, 2 Kim Y.... Kim S. (2000)

    External Searches for AIMP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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    Genome Databases showing AIMP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9255 HGNC: 10648 AceView: SCYE1 Ensembl:ENSG00000164022 euGenes: HUgn9255
    ECgene: AIMP1 H-InvDB: AIMP1

    Other Databases showing AIMP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AIMP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AIMP1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for AIMP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AIMP1 gene:
    Search GeneIP for patents involving AIMP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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