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AIMP1 Gene

protein-coding   GIFtS: 59
GCID: GC04P107236

Aminoacyl TRNA Synthetase Complex-Interacting Multifunctional...

(Previous names: small inducible cytokine subfamily E, member 1 (endothelial...)
(Previous symbol: SCYE1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aminoacyl TRNA Synthetase Complex-Interacting Multifunctional Protein
11 2
     HLD32 5
SCYE11 2 3 5     EMAP II1
EMAP22 3 5     Aminoacyl TRNA Synthase Complex-Interacting Multifunctional Protein 12
Small Inducible Cytokine Subfamily E, Member 1 (Endothelial
Monocyte-Activating)1 2
     Endothelial Monocyte-Activating Polypeptide 22
ARS-Interacting Multifunctional Protein 11 2     Endothelial-Monocyte Activating Polypeptide II2
Multisynthase Complex Auxiliary Component P432 3     Multisynthetase Complex Auxiliary Component P432
EMAPII2 5     p432

External Ids:    HGNC: 106481   Entrez Gene: 92552   Ensembl: ENSG000001640227   OMIM: 6036055   UniProtKB: Q129043   

Export aliases for AIMP1 gene to outside databases

Previous GC identifers: GC04P107458 GC04P102971


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AIMP1 Gene:
The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in
the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the
tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43
subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of
tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after
proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for
this gene. A pseudogene has been identified on chromosome 20. (provided by RefSeq, Dec 2008)

GeneCards Summary for AIMP1 Gene:
AIMP1 (aminoacyl tRNA synthetase complex-interacting multifunctional protein 1) is a protein-coding gene. Diseases associated with AIMP1 include leukodystrophy, hypomyelinating 3, and stromal keratitis. GO annotations related to this gene include tRNA binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: AIMP1_HUMAN, Q12904
Function: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic
arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta
signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation.
Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal
fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic
reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and
endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell
adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7

Gene Wiki entry for AIMP1 (SCYE1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Search for regulatory transcription factor binding sites for AIMP1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAIMP1 promoter sequence
   Search Chromatin IP Primers for AIMP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AIMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q24

AIMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AIMP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P107236:  view genomic region     (about GC identifiers)

Start:
107,236,701 bp from pter      End:
107,270,383 bp from pter
Size:
33,683 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AIMP1_HUMAN, Q12904 (See protein sequence)
Recommended Name: Aminoacyl tRNA synthase complex-interacting multifunctional protein 1  
Size: 312 amino acids; 34353 Da
Subunit: Homodimer. Component of the multisynthase complex which is comprised of a bifunctional
glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and
aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Interacts (via
N-terminus) with RARS (via N-terminus). Interacts (via C-terminus) with SMURF2. Interacts (via N-terminus) with
HSP90B1/gp96 (via C-terminus). Interacts with PSMA7
3 PDB 3D structures from and Proteopedia for AIMP1:
1E7Z (3D)        1EUJ (3D)        1FL0 (3D)    
Secondary accessions: B3KTR2 B4E1S7 Q6FG28 Q96CQ9
Alternative splicing: 2 isoforms:  Q12904-1   Q12904-2   

Explore the universe of human proteins at neXtProt for AIMP1: NX_Q12904

Explore proteomics data for AIMP1 at MOPED

Post-translational modifications: 

  • Cleaved by caspase-7 in response to apoptosis to produce EMAP-II1
  • Ubiquitination2 at Lys9
  • Modification sites at PhosphoSitePlus

  • See AIMP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001135887.1  NP_001135888.1  NP_004748.2  

    ENSEMBL proteins: 
     ENSP00000423681   ENSP00000350699   ENSP00000378191   ENSP00000405248  
    Reactome Protein details: Q12904

    AIMP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for AIMP1
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    Novus Biologicals AIMP1 Proteins
    Sino Biological Recombinant Protein for AIMP1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for AIMP1
    Cloud-Clone Corp. Proteins for AIMP1

    AIMP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for AIMP1 (EMAP-II)
    OriGene Antibodies for AIMP1
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    Novus Biologicals AIMP1 Antibodies
    Abcam antibodies for AIMP1
    Cloud-Clone Corp. Antibodies for AIMP1
    ThermoFisher Antibody for AIMP1
    LSBio Antibodies in human, mouse, rat for AIMP1

    AIMP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AIMP1
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    GenScript Custom Assay Services for AIMP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AIMP1
    Cloud-Clone Corp. CLIAs for AIMP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002547 tRNA-bd_dom
     IPR012340 NA-bd_OB-fold

    Graphical View of Domain Structure for InterPro Entry Q12904

    ProtoNet protein and cluster: Q12904

    UniProtKB/Swiss-Prot: AIMP1_HUMAN, Q12904
    Similarity: Contains 1 tRNA-binding domain


    AIMP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AIMP1_HUMAN, Q12904
    Function: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic
    arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta
    signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation.
    Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal
    fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic
    reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and
    endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell
    adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IDA11306575
    GO:0005125cytokine activity ISS11306575
    GO:0005515protein binding IPI--
    GO:0042803protein homodimerization activity IDA11306575
         
    AIMP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Aimp1):
     homeostasis/metabolism  immune system 

    AIMP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AIMP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AIMP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AIMP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AIMP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target AIMP1:
    hsa-mir-16-5p (MIRT031610), hsa-mir-155-5p (MIRT020704)

    Block miRNA regulation of human, mouse, rat AIMP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AIMP1 (see all 10):
    hsa-miR-3140-3p hsa-miR-101* hsa-miR-340 hsa-miR-1248 hsa-miR-338-5p hsa-miR-514 hsa-miR-3662 hsa-miR-514b-3p
    SwitchGear 3'UTR luciferase reporter plasmidAIMP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AIMP1
    Predesigned siRNA for gene silencing in human, mouse, rat AIMP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AIMP1

    Clone
    Products:
         
    OriGene clones in human, mouse for AIMP1 (see all 18)
    OriGene ORF clones in mouse, rat for AIMP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): AIMP1 (NM_004757)
    Sino Biological Human cDNA Clone for AIMP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AIMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIMP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AIMP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for AIMP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIMP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AIMP1_HUMAN, Q12904: Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle, secretory vesicle (By similarity).
    Secreted (By similarity). Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity). Note=Enriched
    in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels
    (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    extracellular4
    endoplasmic reticulum2
    golgi apparatus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0005829cytosol TAS--

    AIMP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AIMP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Cytosolic tRNA aminoacylation0.57
    2Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for AIMP1
        Cytosolic tRNA aminoacylation



    AIMP1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AIMP1: 
              Inflammatory Cytokines & Receptors in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AIMP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AIMP1 (Q129041, 3 ENSP000003781914) via UniProtKB, MINT, STRING, and/or I2D (see all 158)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP5A1P257053, ENSP000002820504I2D: score=2 STRING: ENSP00000282050
    KARSQ150463, ENSP000003254484I2D: score=1 STRING: ENSP00000325448
    RARSP541363, ENSP000002315724I2D: score=4 STRING: ENSP00000231572
    IQGAP1P469403, ENSP000002681824I2D: score=1 STRING: ENSP00000268182
    AIMP2Q131553, ENSP000002230294I2D: score=2 STRING: ENSP00000223029
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001937negative regulation of endothelial cell proliferation IDA11741979
    GO:0006006glucose metabolic process IEA--
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006915apoptotic process IEA--

    AIMP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AIMP1

    4 Novoseek inferred chemical compound relationships for AIMP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aminoacyl-trna 78.3 9 11818442 (2), 12543078 (2), 16169847 (1), 15627054 (1) (see all 7)
    trna 62.4 8 11292833 (1), 16945568 (1), 19775078 (1), 10801842 (1) (see all 5)
    rapamycin 32.2 12 18029408 (8), 15044617 (3)
    atp 0 1 15710745 (1)



    AIMP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AIMP1 gene (3 alternative transcripts): 
    NM_001142415.1  NM_001142416.1  NM_004757.3  

    Unigene Cluster for AIMP1:

    Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
    Hs.591680  [show with all ESTs]
    Unigene Representative Sequence: NM_004757
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510207 ENST00000358008 ENST00000394701(uc003hyg.3 uc003hyh.3)
    ENST00000442366(uc011cfg.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AIMP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AIMP1 (see all 10):
    hsa-miR-3140-3p hsa-miR-101* hsa-miR-340 hsa-miR-1248 hsa-miR-338-5p hsa-miR-514 hsa-miR-3662 hsa-miR-514b-3p
    SwitchGear 3'UTR luciferase reporter plasmidAIMP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AIMP1
    Predesigned siRNA for gene silencing in human, mouse, rat AIMP1
    Clone
    Products:
         
    OriGene clones in human, mouse for AIMP1 (see all 18)
    OriGene ORF clones in mouse, rat for AIMP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): AIMP1 (NM_004757)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AIMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIMP1
    Primer
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    OriGene qPCR primer pairs and template standards for AIMP1
    OriGene qSTAR qPCR primer pairs in human, mouse for AIMP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AIMP1
      QuantiTect SYBR Green Assays in human, mouse, rat AIMP1
      QuantiFast Probe-based Assays in human, mouse, rat AIMP1

    Additional mRNA sequence: 

    AK095951.1 AK297950.1 AK303965.1 BC014051.2 CR542281.1 U10117.1 

    16 DOTS entries:

    DT.95130846  DT.100041912  DT.316751  DT.91978020  DT.310987  DT.121258679  DT.92389212  DT.97864692 
    DT.121258669  DT.121258672  DT.97863146  DT.87014099  DT.95225503  DT.100667687  DT.121258696  DT.414340 

    Selected AceView cDNA sequences (see all 308):

    AL542578 AA187233 BM973427 AW016119 CB241101 BM676151 BC014051 BU619302 
    BG386696 BQ014417 CR604744 CR624995 AA397977 BM974384 AY527272 AL710316 
    BM973663 AA455908 AA204880 BQ014955 AA621953 CD619292 AI708187 BM911854 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AIMP1 expression in normal human tissues (normalized intensities)      AIMP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCAACAGTG
    AIMP1 Expression
    About this image


    AIMP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Coronary Vessels
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephros
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    AIMP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AIMP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591680
        Pathway & Disease-focused RT2 Profiler PCR Arrays including AIMP1: 
              Inflammatory Cytokines & Receptors in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AIMP1
    OriGene qSTAR qPCR primer pairs in human, mouse for AIMP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AIMP1
    QuantiTect SYBR Green Assays in human, mouse, rat AIMP1
    QuantiFast Probe-based Assays in human, mouse, rat AIMP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIMP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AIMP1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aimp11 , 5 aminoacyl tRNA synthetase complex-interacting multifunctional more1, 5 81.97(n)1
    82.7(a)1
      3 (61.48 cM)5
    137221  NM_007926.21  NP_031952.21 
     1326604985 
    chicken
    (Gallus gallus)
    Aves AIMP11 aminoacyl tRNA synthetase complex-interacting multifunctional more 78.55(n)
    79.81(a)
      422533  XM_420496.4  XP_420496.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    83(a)
    82(a)
    many → 1
    many → 1
    GL343375.1(583-18080)
    GL343384.1(946696-993356)
    African clawed frog
    (Xenopus laevis)
    Amphibia scye1-prov2 small inducible cytokine subfamily E, member 1 76.62(n)    BC046580.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa95a052 Transcribed sequence with moderate similarity to protein more 76.03(n)    AL912984.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG82351 CG8235 49.12(n)
    45.72(a)
      35892  NM_136582.4  NP_610426.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARC1(YGL105W)4 Protein that binds tRNA and methionyl- and glutamyl-tRNA more   --   7(307437-308567) 852773  NP_011410.1 
    soybean
    (Glycine max)
    eudicotyledons CA853507.12   -- 71.25(n)    CA853507.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.32442 Transcribed sequence with weak similarity to protein more 74.5(n)    AV917358.1 


    ENSEMBL Gene Tree for AIMP1 (if available)
    TreeFam Gene Tree for AIMP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AIMP1 gene

    AIMP1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for AIMP1
    PGOHUM00000244338 PGOHUM00000247596


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AIMP1 (see all 580)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs738394321,2
    C,F--102986478(+) TATACA/TTATAC 3 -- int12Minor allele frequency- T:0.06WA 120
    rs1408645471,2
    --107041965(+) TAATAA/GGAAAG 3 -- int10--------
    rs1815653851,2
    --107042018(+) CATAAA/TATAAT 3 -- int10--------
    rs1447170591,2
    --107042304(+) GCTTTC/TTCAAA 3 -- int10--------
    rs1857257431,2
    --107042345(+) GGGGAA/GGACTA 3 -- int10--------
    rs1386695471,2
    --107042410(+) AATCAC/TCTTTT 3 -- int10--------
    rs783462751,2
    C,F--107042499(+) ATTAAT/CGGCTT 3 -- int11Minor allele frequency- C:0.05NA 120
    rs779590061,2
    C--107042506(+) GCTTTG/TTAGGT 3 -- int10--------
    rs1901861111,2
    --107042542(+) GAGAAA/GGACAA 3 -- int10--------
    rs38054071,2
    C--107042583(+) TAATAT/AGTTTC 3 -- int13Minor allele frequency- A:0.21CSA NA EA 241

    HapMap Linkage Disequilibrium report for AIMP1 (107236701 - 107270383 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for AIMP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830029CNV Gain17160897

    Human Gene Mutation Database (HGMD): AIMP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AIMP1
    DNA2.0 Custom Variant and Variant Library Synthesis for AIMP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603605   
    OMIM disorders: 260600  
    UniProtKB/Swiss-Prot: AIMP1_HUMAN, Q12904
  • Leukodystrophy, hypomyelinating, 3 (HLD3) [MIM:260600]: A severe autosomal recessive hypomyelinating
    leukodystrophy characterized by early infantile onset of global developmental delay, lack of development, lack of
    speech acquisition, and peripheral spasticity associated with decreased myelination in the central nervous
    system. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for AIMP1 (see all 42):    About MalaCards
    leukodystrophy, hypomyelinating 3    stromal keratitis    appendicitis    keratitis
    pelizaeus-merzbacher disease    fibrosarcoma    soft tissue sarcoma    leukodystrophy
    traumatic brain injury    brain injury    spinal cord injury    type 1 diabetes mellitus
    neuritis    vaccinia    endotheliitis    alcohol dependence
    type 1 diabetes    prostate adenocarcinoma    colorectal cancer    peritonitis


    AIMP1 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for AIMP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 36.9 11 10880244 (2), 11292833 (1), 18281491 (1), 14982944 (1) (see all 8)
    neovascularization 33.8 2 19565673 (1), 11549594 (1)
    fibrosarcoma 30.2 1 11527006 (1)
    tumors 26.1 47 12374666 (4), 11527006 (4), 10873516 (4), 14688335 (3) (see all 15)
    melanoma 25.1 15 16615114 (5), 10493523 (3), 10873516 (2), 18281491 (1) (see all 5)
    sarcoma 23.5 2 12374666 (1), 16615114 (1)
    inflammation 19.6 7 20469692 (2), 15627054 (1), 11001545 (1), 11527006 (1) (see all 5)
    colorectal cancer 10.9 2 14688335 (1), 14982944 (1)
    cancer 2.98 2 16945568 (1), 11527006 (1)

    Genetic Association Database (GAD): AIMP1
    Human Genome Epidemiology (HuGE) Navigator: AIMP1 (1 document)

    Export disorders for AIMP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AIMP1 gene, integrated from 10 sources (see all 114):
    (articles sorted by number of sources associating them with AIMP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a novel tumor-derived cytokine. Endothelial- monocyte activating polypeptide II. (PubMed id 7929199)1, 2, 3 Kao J.... Stern D.M. (J. Biol. Chem. 1994)
    2. Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome. (PubMed id 19362550)1, 2, 9 Tandle A.T....Libutti S.K. (Exp. Cell Res. 2009)
    3. Proteasomes and RARS modulate AIMP1/EMAP II secretion in human cancer cell lines. (PubMed id 17443684)1, 2, 9 Bottoni A.... Uberti E.C. (J. Cell. Physiol. 2007)
    4. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    5. Pelizaeus-Merzbacher-like disease caused by AIMP1/p43 homozygous mutation. (PubMed id 21092922)1, 2 Feinstein M....Birk O.S. (Am. J. Hum. Genet. 2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Isolation and characterization of human nuclear and cytosolic multisynthetase complexes and the intracellular distribution of p43/EMAPII. (PubMed id 14500886)1, 2 Wolfe C.L.... Norcum M.T. (Protein Sci. 2003)
    9. Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry. (PubMed id 11157763)1, 2 Renault L.... Cherfils J. (EMBO J. 2001)
    10. The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component. (PubMed id 11306575)1, 2 Shalak V....Mirande M. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9255 HGNC: 10648 AceView: SCYE1 Ensembl:ENSG00000164022 euGenes: HUgn9255
    ECgene: AIMP1 H-InvDB: AIMP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AIMP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AIMP1 gene:
    Search GeneIP for patents involving AIMP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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