AIMP1 Gene
protein-coding GIFtS: 55
GCID: GC04P107236
|
|
aminoacyl tRNA synthetase complex-interacting multifunctional...(Previous names: small inducible cytokine subfamily E, member 1 (endothelial...)
(Previous symbol: SCYE1)
| |
Aliases
for AIMP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Aminoacyl TRNA Synthetase Complex-Interacting Multifunctional Protein 11 2 | | EMAP-21 | | SCYE11 2 3 5 | | HLD32 | | EMAPII1 2 5 | | Aminoacyl TRNA Synthase Complex-Interacting Multifunctional Protein 12 | | EMAP22 3 5 | | ARS-Interacting Multifunctional Protein 12 | | P431 | | Endothelial Monocyte-Activating Polypeptide 22 | | Small Inducible Cytokine Subfamily E, Member 1 (EndothelialMonocyte-Activating)1 2 | | Endothelial-Monocyte Activating Polypeptide II2 | | Multisynthase Complex Auxiliary Component P432 3 | | Multisynthetase Complex Auxiliary Component P432 |
Export aliases for AIMP1 gene to outside databasesPrevious GC identifers: GC04P107458 GC04P102971 |
Summaries
for AIMP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for AIMP1:
The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in thecontrol of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associatedvasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which isassociated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase innormal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage intumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene hasbeen identified on chromosome 20. (provided by RefSeq, Dec 2008)
UniProtKB/Swiss-Prot: AIMP1_HUMAN, Q12904Function: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmicarginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signalingthrough stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved inglucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblastproliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum.Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cellapoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulatesendothelial cell responses by degrading HIF-1A through interaction with PSMA7
Gene Wiki entry for AIMP1 (SCYE1)
|
Genomic Views
for AIMP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for AIMP1
Other transcription factors
Search SABiosciences Chromatin IP Primers for AIMP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AIMP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q24 Ensembl cytogenetic band: 4q24 HGNC cytogenetic band: 4q24AIMP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P107236: view genomic region
(about GC identifiers)
Start:
|
107,236,701 bp from pter |
End:
|
107,270,383 bp from pter |
Size:
|
33,683 bases |
Orientation:
|
plus strand |
|
Proteins
for AIMP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AIMP1_HUMAN, Q12904 (See
protein sequence)Recommended Name: Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 Size: 312 amino acids; 34353 Da
Subunit: Homodimer. Component of the multisynthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNAsynthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, andthree auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Interacts (via N-terminus) with RARS (via N-terminus).Interacts (via C-terminus) with SMURF2. Interacts (via N-terminus) with HSP90B1/gp96 (via C-terminus). Interacts withPSMA7
Subcellular location: Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle, secretory vesicle (By similarity). Secreted (Bysimilarity). Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity). Note=Enriched in secretoryvesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity).Also secreted in response to hypoxia and both apoptotic and necrotic cell death
3 PDB 3D structures from  and Proteopedia  for AIMP1:1E7Z (3D)
1EUJ (3D)
1FL0 (3D)
Secondary accessions: B3KTR2 B4E1S7 Q6FG28 Q96CQ9Alternative splicing: 2 isoforms: Q12904-1 Q12904-2 Explore the universe of human proteins at neXtProt for AIMP1: NX_Q12904
Post-translational modifications:
Cleaved by caspase-7 in response to apoptosis to produce EMAP-II1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q12904
AIMP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001135887.1 NP_001135888.1 NP_004748.2
ENSEMBL proteins: ENSP00000423681 ENSP00000350699 ENSP00000378191 ENSP00000405248 Reactome Protein details: Q12904
Human Recombinant Protein Products for AIMP1:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
AIMP1 for ontologies About GeneDecksing
AIMP1 Antibody Products:
Assay Products for AIMP1: |
Protein
Domains /
Families
for AIMP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AIMP1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q12904ProtoNet protein and cluster: Q12904 UniProtKB/Swiss-Prot: AIMP1_HUMAN, Q12904Similarity: Contains 1 tRNA-binding domain |
Function
for AIMP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: AIMP1_HUMAN, Q12904Function: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmicarginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signalingthrough stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved inglucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblastproliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum.Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cellapoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulatesendothelial cell responses by degrading HIF-1A through interaction with PSMA7 Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
AIMP1 for ontologies About GeneDecksing
Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Aimp1):
AIMP1 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AIMP1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AIMP1 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): AIMP1 (NM_004757) | |  | Sino Biological Human cDNA Clone for AIMP1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AIMP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIMP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIMP1 |
|
Pathways & Interactions
for AIMP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | tRNA Aminoacylation | | | 2 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for AIMP1
AIMP1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AIMP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/71 Interacting proteins for AIMP1 (Q129041, 3 ENSP000003781914) via UniProtKB, MINT, STRING, and/or I2D (see all 71)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
AIMP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for AIMP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
AIMP1 for compounds About GeneDecksing
 Browse Tocris compounds for AIMP1
4 Novoseek chemical compound relationships for AIMP1 gene About this table
Search CenterWatch for drugs/clinical trials and news about AIMP1
|
Transcripts
for AIMP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AIMP1 gene (3 alternative transcripts): NM_001142415.1 NM_001142416.1 NM_004757.3 Unigene Cluster for AIMP1: Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 Hs.591680 [show with all ESTs]Unigene Representative Sequence: NM_0047574 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000510207 ENST00000358008 ENST00000394701(uc003hyg.3 uc003hyh.3)
ENST00000442366(uc011cfg.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AIMP1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AIMP1 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): AIMP1 (NM_004757) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AIMP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIMP1 |
Additional cDNA sequence: AK095951.1 AK297950.1 AK303965.1 BC014051.2 CR542281.1 U10117.1 16 DOTS entries: DT.95130846 DT.100041912 DT.316751 DT.91978020 DT.310987 DT.121258679 DT.92389212 DT.97864692 DT.121258669 DT.121258672 DT.97863146 DT.87014099 DT.95225503 DT.100667687 DT.121258696 DT.414340 24/308 AceView cDNA sequences (see all 308): AU132717 NM_004757 CR602436 CA487163 AA455165 AI479525 AA828405 AA503544 AA566076 BE538179 W57697 AA485242 BF436271 U10117 BQ014955 BU625554 CD619284 AI458348 CR604744 CB242243 CD619292 AA204880 BM973427 BG677406
GeneLoc Exon Structure
|
Expression
for AIMP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AIMP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCAACAGTG
About this image
See AIMP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AIMP1
SOURCE GeneReport for Unigene cluster: Hs.591680
SABiosciences Expression via Pathway-Focused PCR Arrays including AIMP1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AIMP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AIMP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AIMP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AIMP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIMP1 |
Orthologs
for AIMP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for AIMP1 gene from 9/32 species (see all 32) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Aimp11 , 5 |
aminoacyl tRNA synthetase complex-interacting multifunctional more1, 5 |
84.38(n)1
85.85(a)1 |
|
3 (61.48 cM)5
137221 NM_007926.21 NP_031952.21
1326604985 |
chicken
(Gallus gallus) |
Aves |
AIMP11 |
aminoacyl tRNA synthetase complex-interacting multifunctional more |
78.55(n)
79.81(a) |
|
422533 XM_420496.3 XP_420496.3 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
82(a) |
1 ↔ 1 |
GL343384.1(946699-962572) |
African clawed frog
(Xenopus laevis) |
Amphibia |
scye1-prov2 |
small inducible cytokine subfamily E, member 1 |
76.62(n) |
|
BC046580.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufa95a052 |
Transcribed sequence with moderate similarity to protein more |
76.03(n) |
|
AL912984.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG82351 |
CG8235 |
50.22(n)
46.05(a) |
|
35892 NM_136582.3 NP_610426.2 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G599806AT2G406606 |
Nucleic acid-binding, OB-fold-like proteinOB-fold nucleic acid binding domain-containing pro... |
29(a)24(a) |
possible ortholog1 ↔ 1 |
3(22154244-22155641) 2(16965933-16969035) |
rice
(Oryza sativa) |
Liliopsida |
---- |
methionyl-tRNA synthetase, putative, expressed |
31(a)23(a) |
possible ortholog1 ↔ 1 |
4(13598671-13601147) 1(35068203-35073448) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
ygjH6 |
conserved tRNA binding protein |
34(a) |
1 ↔ 1 |
Chromosome(3218937-3219269) |
ENSEMBL Gene Tree for AIMP1 (if available)
TreeFam Gene Tree for AIMP1 (if available) |
Paralogs
for AIMP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AIMP1 gene
AIMP1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for AIMP1
PGOHUM00000244338 PGOHUM00000247596
|
Genomic Variants
for AIMP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AIMP1 (107236701 - 107270383 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for AIMP1
1 CNV: 34436
Human Gene Mutation Database (HGMD): AIMP1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AIMP1 |
|
Disorders
/ Diseases
for AIMP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AIMP1 for disorders About GeneDecksing
OMIM gene information: 603605
OMIM disorders: --
UniProtKB/Swiss-Prot: AIMP1_HUMAN, Q12904
Defects in AIMP1 are the cause of leukodystrophy hypomyelinating type 3 (HLD3) [MIM:260600]. A severeautosomal recessive hypomyelinating leukodystrophy characterized by early infantile onset of global developmentaldelay, lack of development, lack of speech acquisition, and peripheral spasticity associated with decreasedmyelination in the central nervous system
20/33  diseases for AIMP1 (see all 33): About MalaCardspelizaeus-merzbacher-like disease spinal cord injury pelizaeus-merzbacher disease traumatic brain injury
soft tissue sarcoma type 1 diabetes mellitus brain injury diabetes mellitus
alcohol dependence appendicitis fibrosarcoma leukodystrophy
neuritis keratitis emphysema sarcoma
colorectal cancer vaccinia spasticity prostate adenocarcinoma
9 Novoseek disease relationships for AIMP1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
36.9 |
11 |
10880244 (2), 11292833 (1), 18281491 (1), 14982944 (1) (see all 8) |
| neovascularization |
33.8 |
2 |
19565673 (1), 11549594 (1) |
| fibrosarcoma |
30.2 |
1 |
11527006 (1) |
| tumors |
26.1 |
47 |
12374666 (4), 11527006 (4), 10873516 (4), 14688335 (3) (see all 15) |
| melanoma |
25.1 |
15 |
16615114 (5), 10493523 (3), 10873516 (2), 18281491 (1) (see all 5) |
| sarcoma |
23.5 |
2 |
12374666 (1), 16615114 (1) |
| inflammation |
19.6 |
7 |
20469692 (2), 15627054 (1), 11001545 (1), 11527006 (1) (see all 5) |
| colorectal cancer |
10.9 |
2 |
14688335 (1), 14982944 (1) |
| cancer |
2.98 |
2 |
16945568 (1), 11527006 (1) |
Human Genome Epidemiology (HuGE) Navigator: AIMP1 (1 document)
Export disorders for AIMP1 gene to outside databases
|
Publications
for AIMP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AIMP1 gene, integrated from 9 sources (see all 107):
(articles sorted by number of sources associating them with AIMP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of a novel tumor-derived cytokine. Endothelial- monocyte activating polypeptide II. (PubMed id 7929199)1, 2, 3 Kao J.... Stern D.M. (1994)
- Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome. (PubMed id 19362550)1, 2, 9 Tandle A.T....Libutti S.K. (2009)
- Proteasomes and RARS modulate AIMP1/EMAP II secretion in human cancer cell lines. (PubMed id 17443684)1, 2, 9 Bottoni A....Uberti E.C. (2007)
- Pelizaeus-Merzbacher-like disease caused by AIMP1/p43 homozygous mutation. (PubMed id 21092922)1, 2 Feinstein M....Birk O.S. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Isolation and characterization of human nuclear and cytosolic multisynthetase complexes and the intracellular distribution of p43/EMAPII. (PubMed id 14500886)1, 2 Wolfe C.L.... Norcum M.T. (2003)
- Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry. (PubMed id 11157763)1, 2 Renault L.... Cherfils J. (2001)
- The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component. (PubMed id 11306575)1, 2 Shalak V....Mirande M. (2001)
- A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases. (PubMed id 10852899)1, 2 Kim Y.... Kim S. (2000)
|
External Searches for AIMP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AIMP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AIMP1 gene
(According to HUGE)
About This Section
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Specialized Databases showing AIMP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for AIMP1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for AIMP1 gene:
Search GeneIP for patents involving AIMP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for AIMP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for AIMP1 | | OriGene shRNA RFP for AIMP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AIMP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AIMP1 | | | OriGene Protein Over-expression Lysate for AIMP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AIMP1 | | OriGene 3'-UTR Clone for AIMP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AIMP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AIMP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for AIMP1 | | OriGene Custom Protein Services for AIMP1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AIMP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AIMP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AIMP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AIMP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AIMP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AIMP1 |
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| | | | Search Tocris compounds for AIMP1 |
| |  |  |  |  | | | | | | Recombinant Protein for AIMP1 |
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 | | | AIMP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIMP1 |
|  |  |  |  | | | | ThermoFisher Antibodies for AIMP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIMP1 |
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