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Aliases for AIMP1 Gene

Aliases for AIMP1 Gene

  • Aminoacyl TRNA Synthetase Complex-Interacting Multifunctional Protein 1 2 3
  • EMAP2 3 4 6
  • SCYE1 3 4 6
  • Small Inducible Cytokine Subfamily E, Member 1 (Endothelial Monocyte-Activating) 2 3
  • Multisynthase Complex Auxiliary Component P43 3 4
  • ARS-Interacting Multifunctional Protein 1 2 3
  • EMAPII 3 6
  • HLD3 3 6
  • Aminoacyl TRNA Synthase Complex-Interacting Multifunctional Protein 1 3
  • Multisynthetase Complex Auxiliary Component P43 3
  • Endothelial-Monocyte Activating Polypeptide II 3
  • Endothelial Monocyte-Activating Polypeptide 2 3
  • EMAP II 2
  • P43 3

External Ids for AIMP1 Gene

Previous Symbols for AIMP1 Gene

  • SCYE1

Summaries for AIMP1 Gene

Entrez Gene Summary for AIMP1 Gene

  • The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]

GeneCards Summary for AIMP1 Gene

AIMP1 (Aminoacyl TRNA Synthetase Complex-Interacting Multifunctional Protein 1) is a Protein Coding gene. Diseases associated with AIMP1 include leukodystrophy, hypomyelinating, 3 and pelizaeus-merzbacher-like disease due to aimp1 mutation. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include protein homodimerization activity and tRNA binding.

UniProtKB/Swiss-Prot for AIMP1 Gene

  • Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.

Gene Wiki entry for AIMP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AIMP1 Gene

Genomics for AIMP1 Gene

Genomic Location for AIMP1 Gene

Start:
106,315,544 bp from pter
End:
106,349,226 bp from pter
Size:
33,683 bases
Orientation:
Plus strand

Genomic View for AIMP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AIMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AIMP1 Gene

No data available for Regulatory Elements for AIMP1 Gene

Proteins for AIMP1 Gene

  • Protein details for AIMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12904-AIMP1_HUMAN
    Recommended name:
    Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
    Protein Accession:
    Q12904
    Secondary Accessions:
    • B3KTR2
    • B4E1S7
    • Q6FG28
    • Q96CQ9

    Protein attributes for AIMP1 Gene

    Size:
    312 amino acids
    Molecular mass:
    34353 Da
    Quaternary structure:
    • Homodimer. Component of the multisynthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Interacts (via N-terminus) with RARS (via N-terminus). Interacts (via C-terminus) with SMURF2. Interacts (via N-terminus) with HSP90B1/gp96 (via C-terminus). Interacts with PSMA7.

    Three dimensional structures from OCA and Proteopedia for AIMP1 Gene

    Alternative splice isoforms for AIMP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AIMP1 Gene

Proteomics data for AIMP1 Gene at MOPED

Post-translational modifications for AIMP1 Gene

  • Cleaved by caspase-7 in response to apoptosis to produce EMAP-II
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys9 and Lys24

Other Protein References for AIMP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for AIMP1 Gene

Domains for AIMP1 Gene

Protein Domains for AIMP1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q12904

UniProtKB/Swiss-Prot:

AIMP1_HUMAN
Domain:
  • Contains 1 tRNA-binding domain.:
    • Q12904
genes like me logo Genes that share domains with AIMP1: view

No data available for Gene Families for AIMP1 Gene

Function for AIMP1 Gene

Molecular function for AIMP1 Gene

UniProtKB/Swiss-Prot Function: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.

Gene Ontology (GO) - Molecular Function for AIMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IDA 11306575
GO:0004825 NOT methionine-tRNA ligase activity IBA --
GO:0005125 cytokine activity ISS 11306575
GO:0005515 protein binding IPI 11741979
GO:0042803 protein homodimerization activity IDA 11306575
genes like me logo Genes that share ontologies with AIMP1: view

Phenotypes for AIMP1 Gene

genes like me logo Genes that share phenotypes with AIMP1: view

miRNA for AIMP1 Gene

miRTarBase miRNAs that target AIMP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for AIMP1 Gene

Localization for AIMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AIMP1 Gene

Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle, secretory vesicle. Secreted. Endoplasmic reticulum. Golgi apparatus. Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AIMP1 Gene COMPARTMENTS Subcellular localization image for AIMP1 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 4
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AIMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with AIMP1: view

Pathways for AIMP1 Gene

genes like me logo Genes that share pathways with AIMP1: view

Pathways by source for AIMP1 Gene

Gene Ontology (GO) - Biological Process for AIMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001937 negative regulation of endothelial cell proliferation IDA 11741979
GO:0006006 glucose metabolic process IEA --
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006431 NOT methionyl-tRNA aminoacylation IBA --
genes like me logo Genes that share ontologies with AIMP1: view

Compounds for AIMP1 Gene

(4) Novoseek inferred chemical compound relationships for AIMP1 Gene

Compound -log(P) Hits PubMed IDs
aminoacyl-trna 78.3 9
trna 62.4 5
rapamycin 32.2 11
atp 0 1
genes like me logo Genes that share compounds with AIMP1: view

Transcripts for AIMP1 Gene

Unigene Clusters for AIMP1 Gene

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AIMP1 Gene

No ASD Table

Relevant External Links for AIMP1 Gene

GeneLoc Exon Structure for
AIMP1
ECgene alternative splicing isoforms for
AIMP1

Expression for AIMP1 Gene

mRNA expression in normal human tissues for AIMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AIMP1 Gene

SOURCE GeneReport for Unigene cluster for AIMP1 Gene Hs.591680

genes like me logo Genes that share expressions with AIMP1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AIMP1 Gene

Orthologs for AIMP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AIMP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AIMP1 35
  • 99.48 (n)
  • 98.75 (a)
AIMP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AIMP1 35
  • 88.79 (n)
  • 85.98 (a)
SCYE1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
AIMP1 35
  • 90.86 (n)
  • 90.34 (a)
mouse
(Mus musculus)
Mammalia Aimp1 35
  • 81.97 (n)
  • 82.7 (a)
Aimp1 16
Aimp1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AIMP1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AIMP1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aimp1 35
  • 83.92 (n)
  • 87.3 (a)
chicken
(Gallus gallus)
Aves AIMP1 35
  • 78.55 (n)
  • 79.81 (a)
AIMP1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia scye1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia aimp1 35
  • 71.4 (n)
  • 72.61 (a)
zebrafish
(Danio rerio)
Actinopterygii aimp1 35
  • 64.51 (n)
  • 65.05 (a)
aimp1 36
  • 66 (a)
OneToMany
AIMP1 (1 of 2) 36
  • 40 (a)
OneToMany
wufa95a05 35
fruit fly
(Drosophila melanogaster)
Insecta CG8235 35
  • 49.12 (n)
  • 45.72 (a)
CG8235 36
  • 44 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARC1 36
  • 29 (a)
OneToOne
ARC1 38
barley
(Hordeum vulgare)
Liliopsida Hv.3244 35
Species with no ortholog for AIMP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AIMP1 Gene

ENSEMBL:
Gene Tree for AIMP1 (if available)
TreeFam:
Gene Tree for AIMP1 (if available)

Paralogs for AIMP1 Gene

Pseudogenes.org Pseudogenes for AIMP1 Gene

genes like me logo Genes that share paralogs with AIMP1: view

No data available for Paralogs for AIMP1 Gene

Variants for AIMP1 Gene

Sequence variations from dbSNP and Humsavar for AIMP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs13534 -- 106,348,870(+) GTATA(A/G)ACATT utr-variant-3-prime
rs478730 -- 106,321,393(+) cctgg(A/C)cgcaa intron-variant
rs676773 -- 106,321,394(-) gttgc(A/G)gccag intron-variant
rs677692 -- 106,321,203(-) ATGGG(C/T)GGCCA intron-variant
rs1134648 - 106,328,087(+) AAATA(C/G)CATTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for AIMP1 Gene

Variant ID Type Subtype PubMed ID
nsv830029 CNV Gain 17160897

Relevant External Links for AIMP1 Gene

HapMap Linkage Disequilibrium report
AIMP1
Human Gene Mutation Database (HGMD)
AIMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AIMP1 Gene

Disorders for AIMP1 Gene

(1) OMIM Diseases for AIMP1 Gene (603605)

UniProtKB/Swiss-Prot

AIMP1_HUMAN
  • Leukodystrophy, hypomyelinating, 3 (HLD3) [MIM:260600]: A severe autosomal recessive hypomyelinating leukodystrophy characterized by early infantile onset of global developmental delay, lack of development, lack of speech acquisition, and peripheral spasticity associated with decreased myelination in the central nervous system. {ECO:0000269 PubMed:21092922}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(9) Novoseek inferred disease relationships for AIMP1 Gene

Disease -log(P) Hits PubMed IDs
necrosis 36.9 9
neovascularization 33.8 2
fibrosarcoma 30.2 1
tumors 26.1 32
melanoma 25.1 12

Relevant External Links for AIMP1

Genetic Association Database (GAD)
AIMP1
Human Genome Epidemiology (HuGE) Navigator
AIMP1
genes like me logo Genes that share disorders with AIMP1: view

Publications for AIMP1 Gene

  1. Proteasomes and RARS modulate AIMP1/EMAP II secretion in human cancer cell lines. (PMID: 17443684) Bottoni A. … Uberti E.C. (J. Cell. Physiol. 2007) 3 4 23
  2. Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome. (PMID: 19362550) Tandle A.T. … Libutti S.K. (Exp. Cell Res. 2009) 3 4 23
  3. Characterization of a novel tumor-derived cytokine. Endothelial- monocyte activating polypeptide II. (PMID: 7929199) Kao J. … Stern D.M. (J. Biol. Chem. 1994) 2 3 4
  4. The significance of EMAP-II after allogeneic stem cell transplantation. (PMID: 19565673) Nomura S. … Hayashi K. (Transpl. Immunol. 2009) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for AIMP1 Gene

Sources for AIMP1 Gene

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