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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AIM2 Gene

protein-coding   GIFtS: 61
GCID: GC01M159032

Absent In Melanoma 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Absent In Melanoma 21 2 3
PYHIN42
Interferon-Inducible Protein AIM22

External Ids:    HGNC: 3571   Entrez Gene: 94472   Ensembl: ENSG000001635687   OMIM: 6045785   UniProtKB: O148623   

Export aliases for AIM2 gene to outside databases

Previous GC identifers: GC01M156824 GC01M154764 GC01M155810 GC01M156249 GC01M155845 GC01M157298 GC01M130389


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AIM2 Gene:
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control
cell proliferation. Interferon-gamma induces expression of AIM2. (provided by RefSeq, Jul 2008)

GeneCards Summary for AIM2 Gene: 
AIM2 (absent in melanoma 2) is a protein-coding gene. Diseases associated with AIM2 include melanoma, and gingivitis, and among its related super-pathways are NOD1/2 Signaling Pathway and Immune System. GO annotations related to this gene include double-stranded DNA binding and identical protein binding. An important paralog of this gene is IFI16.

UniProtKB/Swiss-Prot: AIM2_HUMAN, O14862
Function: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing
caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo
oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of
interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a
non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves
caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity

Gene Wiki entry for AIM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AIM2 gene promoter:
         GATA-3   POU6F1 (c2)   Evi-1   GATA-1   GATA-2   S8   FOXO4   FOXJ2 (long isoform)   FOXJ2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AIM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for AIM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AIM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q22

AIM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AIM2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M159032:  view genomic region     (about GC identifiers)

Start:
159,032,274 bp from pter      End:
159,116,886 bp from pter
Size:
84,613 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AIM2_HUMAN, O14862 (See protein sequence)
Recommended Name: Interferon-inducible protein AIM2  
Size: 343 amino acids; 38954 Da
Subunit: Self-associates; forms homooligomers in response to cytosolic dsDNA and the dsDNA seems to serve as
oligomerization platform. Component of the AIM2 inflammasome. Interacts with PYCARD, IFI16, EIF2AK2/PKR and
MAPRE1
Subcellular location: Nucleus. Cytoplasm. Note=Activated inflammasomes can aggregate in the cytosol as speck-like
particles
Miscellaneous: Defects in AIM2 may be a cause of microsatellite unstable colon cancers
Sequence caution: Sequence=AAH10940.1; Type=Frameshift; Positions=340;
3 PDB 3D structures from and Proteopedia for AIM2:
3RN2 (3D)        3RN5 (3D)        3VD8 (3D)    
Secondary accessions: A8K7M7 Q5T3V9 Q96FG9

Explore the universe of human proteins at neXtProt for AIM2: NX_O14862

Explore proteomics data for AIM2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14862

  • AIM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AIM2 Protein Expression
    REFSEQ proteins: NP_004824.1  
    ENSEMBL proteins: 
     ENSP00000357112   ENSP00000357111   ENSP00000405197  
    Reactome Protein details: O14862
    Human Recombinant Protein Products for AIM2: 
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    Sino Biological Recombinant Protein for AIM2
    Sino Biological Cell Lysate for AIM2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AIM2 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA19158676
    GO:0005739mitochondrion IDA--
    GO:0005829cytosol TAS--

    AIM2 for ontologies           About GeneDecksing



    AIM2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for AIM2 

    Assay Products for AIM2: 
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    Cloud-Clone Corp. CLIAs for AIM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR004021 HIN200/IF120x
     IPR012340 NA-bd_OB-fold
     IPR004020 DAPIN
     IPR011029 DEATH-like_dom

    Graphical View of Domain Structure for InterPro Entry O14862

    ProtoNet protein and cluster: O14862

    2 Blocks protein domains:
    IPB004020 Pyrin domain
    IPB004021 HIN-200/IF120x domain


    UniProtKB/Swiss-Prot: AIM2_HUMAN, O14862
    Domain: The DAPIN domain mediates homotypic interaction with PYCARD (PubMed=19158676 and PubMed:19158675)
    Domain: The HIN-20 domain mediates dsDNA binding via electrostatic interactions (PubMed:22483801)
    Similarity: Belongs to the HIN-200 family
    Similarity: Contains 1 DAPIN domain
    Similarity: Contains 1 HIN-200 domain


    AIM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AIM2_HUMAN, O14862
    Function: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing
    caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo
    oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of
    interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a
    non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves
    caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity
    Enzyme regulation: In absence of dsDNA DAPIN and HIN-20 domain can interact inducing a closed conformation; an
    autoinhibitory mechanism is proposed in which binding to dsDNA liberates the DAPIN domain for homotypic
    downstream signaling interactions with PYCARD
    Induction: By IFNG/IFN-gamma and IFNB1/IFN-beta

         Genatlas biochemistry entry for AIM2:
    interferon gamma inducible gene,homolog to the tightly linked genes IFI16,MNDA,expressed in spleen,small
    intestine,peripheral blood leukocytes,39.5kDa,absent in melanoma 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003690double-stranded DNA binding IDA19158675
    GO:0005515protein binding IPI19158676
    GO:0042802identical protein binding IPI19158676
         
    AIM2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for AIM2:
     Decreased number of cells in m  Synthetic lethal with c-Myc af 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Aim2):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    AIM2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for AIM2: Aim2tm1.1Vmd Aim2tm1Ktak

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AIM2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AIM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AIM2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AIM2 

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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIM2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AIM2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.69
    NOD pathway0.33
    2Immune System
    Immune System0.56
    Innate Immune System0.50
    3Inflammasomes
    Inflammasomes0.71
    4Cytosolic DNA-sensing pathway
    Cytosolic DNA-sensing pathway0.36
    5The AIM2 inflammasome
    The AIM2 inflammasome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for AIM2
        Lymphocyte Signaling

    1 BioSystems Pathway for AIM2
        NOD pathway


    5        Reactome Pathways for AIM2
        The AIM2 inflammasome
    Inflammasomes
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Immune System
    Innate Immune System


    1         Kegg Pathway  (Kegg details for AIM2):
        Cytosolic DNA-sensing pathway


    AIM2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AIM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for AIM2 (O148621, 3 ENSP000003571124) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PYCARDQ9ULZ31, 3, ENSP000002474704EBI-6253193,EBI-751215 I2D: score=1 STRING: ENSP00000247470
    AIM2O148621EBI-6253193,EBI-6253193
    LAMP1ENSP000003332984STRING: ENSP00000333298
    BECN1ENSP000003552314STRING: ENSP00000355231
    SQSTM1ENSP000003744554STRING: ENSP00000374455
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002218activation of innate immune response IDA19158675
    GO:0002230positive regulation of defense response to virus by host ISS--
    GO:0006915apoptotic process IEA--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response TAS9242382

    AIM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AIM2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AIM2

    1 Novoseek inferred chemical compound relationship for AIM2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mnda 98 8 9242382 (2), 10828447 (1), 11215814 (1), 19762380 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about AIM2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AIM2 gene: 
    NM_004833.1  

    Unigene Cluster for AIM2:

    Absent in melanoma 2
    Hs.733411  [show with all ESTs]
    Unigene Representative Sequence: AK292042
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368130(uc001ftj.1) ENST00000481829 ENST00000368129 ENST00000411768

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF024714.1 AK292042.1 BC010940.1 U52053.1 

    5 DOTS entries:

    DT.310623  DT.97770207  DT.310624  DT.92415868  DT.100711389 

    24/34 AceView cDNA sequences (see all 34):

    CB053629 AA458912 NM_004833 AF024714 BM717965 CB151016 BU599245 CD366430 
    AA215558 AA568884 CF137554 AA767288 BC010940 AA555091 CA432643 U52053 
    BU943059 CD703806 CD107288 AW294096 AA459132 BI912227 BP339102 BF244586 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AIM2 expression in normal human tissues (normalized intensities)      AIM2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTACAGTGGC
    AIM2 Expression
    About this image


    AIM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Spleen (Hematopoietic System)
             splenocytes   
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Blood (Hematopoietic System)
             b cells   
     
     Lymph (Hematopoietic System)
             LYMPH NODE   

    See AIM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AIM2

    SOURCE GeneReport for Unigene cluster: Hs.733411

    UniProtKB/Swiss-Prot: AIM2_HUMAN, O14862
    Tissue specificity: Expressed in spleen, small intestine, peripheral blood leukocytes, and testis

        SABiosciences Expression via Pathway-Focused PCR Arrays including AIM2: 
              Antiviral Response in human mouse rat
              Inflammasomes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for AIM2 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aim21 , 5 absent in melanoma 21, 5 69.12(n)1
    56.93(a)1
      1 (80.33 cM)5
    3836191  NM_001013779.21  NP_001013801.21 
     1733508795 


    ENSEMBL Gene Tree for AIM2 (if available)
    TreeFam Gene Tree for AIM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AIM2 gene
    IFI162  PYHIN12  MNDA2  
    2 SIMAP similar genes for AIM2 using alignment to 4 protein entries:     AIM2_HUMAN (see all proteins):
    IFI16    MNDA

    AIM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/360 SNPs in AIM2 are shown (see all 360)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0433794
    ----see VAR_0433792 C Y mis40--------
    rs1820153301,2
    C--159031912(+) ACTGTA/C/GAATGT 1 -- int10--------
    rs1836196251,2
    C--159031937(+) GGCTCC/TCTAGT 1 -- int10--------
    rs589173231,2
    C,F--159031976(+) CTCCAA/TTAACA 1 -- int12Minor allele frequency- T:0.21WA 120
    rs1489389391,2
    C--159032090(+) TACTGC/TGCTGC 1 -- int10--------
    rs1128737431,2
    C,F--159032129(+) GTGTAC/TTCCTA 1 -- int13Minor allele frequency- T:0.03CSA WA 121
    rs27938451,2
    C,F,O,H--159032255(+) CTAAAT/GGAGAT 1 -- int136Minor allele frequency- G:0.23NS EA NA WA CSA 3154
    rs1892753271,2
    --159032397(+) ACTTAC/GAATCT 1 -- ut310--------
    rs746897141,2
    C,F--159032484(+) TCTCTA/CTGTTT 2 E * stop-lost2Minor allele frequency- C:0.01WA NA 4664
    rs1808987261,2
    C--159032519(+) TGGAGA/GAAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for AIM2 (159032274 - 159116886 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for AIM2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv872486CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604578    OMIM disorders: --

    8 diseases for AIM2:    About MalaCards
    melanoma    gingivitis    burkitt's lymphoma    systemic lupus erythematosus
    lupus erythematosus    colon cancer    colorectal cancer    breast cancer


    AIM2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for AIM2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 31.7 6 10828447 (2), 15582594 (2), 9242382 (1)
    tumors 0 3 15076139 (2), 15582594 (1)

    Genetic Association Database (GAD): AIM2
    Human Genome Epidemiology (HuGE) Navigator: AIM2 (1 document)

    Export disorders for AIM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AIM2 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with AIM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma. (PubMed id 9242382)1, 2, 3, 9 DeYoung K.L.... Trent J.M. (1997)
    2. Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2. (PubMed id 15582594)1, 2, 9 Cresswell K.S....Johnstone R.W. (2005)
    3. Structures of the HIN domain:DNA complexes reveal liga nd binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor . (PubMed id 22483801)1, 2 Jin T....Xiao T.S. (2012)
    4. Interactome-wide analysis identifies end-binding protein 1 as a crucial component for the speck-like particle formation of activated AIM2 inflammasomes. (PubMed id 22869553)1, 2 Wang L.J.... Chang Y.S. (2012)
    5. Association of IFI200 gene polymorphisms with suscept ibility to systemic lupus erythematosus. (PubMed id 20595294)1, 4 Kimkong I....Hirankarn N. (2010)
    6. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. (PubMed id 19158676)1, 2 Fernandes-Alnemri T....Alnemri E.S. (2009)
    7. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. (PubMed id 19158679)1, 2 BA1rckstA1mmer T....Superti-Furga G. (2009)
    8. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. (PubMed id 19158675)1, 2 Hornung V....Fitzgerald K.A. (2009)
    9. The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers. (PubMed id 17726700)1, 2 Woerner S.M.... Dihlmann S. (2007)
    10. AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. (PubMed id 16432157)1, 2 Chen I.-F.... Hung M.-C. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9447 HGNC: 357 AceView: AIM2 Ensembl:ENSG00000163568 euGenes: HUgn9447
    ECgene: AIM2 Kegg: 9447 H-InvDB: AIM2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AIM2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AIM2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AIM2 gene:
    Search GeneIP for patents involving AIM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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