AIM1L Gene
protein-coding GIFtS: 45
GCID: GC01M026648
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|
absent in melanoma 1-like
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Aliases
for AIM1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Absent In Melanoma 1-Like1 2 | | CRYBG21 2 3 | | Beta/Gamma Crystallin Domain-Containing Protein 22 3 | | FLJ380201 | | Absent In Melanoma 1-Like Protein2 | | Beta-Gamma Crystallin Domain Containing 22 |
Export aliases for AIM1L gene to outside databasesPrevious GC identifers: GC00U990701 GC01M025670 GC01M025882 GC01M026253 GC01M026332 GC01M026521 GC01M024902 |
Summaries
for AIM1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for AIM1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AIM1L gene promoter:
c-Fos GR E2F-4 E2F-3a E2F-5 AP-1 E2F-2 E2F E2F-1 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for AIM1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AIM1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.11 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p35AIM1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M026648: view genomic region
(about GC identifiers)
Start:
|
26,648,350 bp from pter |
End:
|
26,680,621 bp from pter |
Size:
|
32,272 bases |
Orientation:
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minus strand |
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Proteins
for AIM1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AIM1L_HUMAN, Q8N1P7 (See
protein sequence)Recommended Name: Absent in melanoma 1-like protein Size: 616 amino acids; 68646 Da
Sequence caution: Sequence=CAI15847.1; Type=Erroneous gene model prediction; Sequence=CAI15850.2; Type=Erroneous genemodel prediction;
Secondary accessions: B2RNG3 Q5T137 Q5T150Explore the universe of human proteins at neXtProt for AIM1L: NX_Q8N1P7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N1P7
AIM1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001034864.2
ENSEMBL proteins: ENSP00000433931 ENSP00000409834 ENSP00000363323 ENSP00000428746 ENSP00000310435 ENSP00000416093 ENSP00000442623
Human Recombinant Protein Products:
AIM1L Antibody Products:
Assay Products for AIM1L: |
Protein
Domains /
Families
for AIM1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AIM1L for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N1P7ProtoNet protein and cluster: Q8N1P7 3 Blocks protein families: IPB000772 Ricin B lectin domain IPB001064 Beta and gamma crystallin IPB011024 Gamma-crystallin related
UniProtKB/Swiss-Prot: AIM1L_HUMAN, Q8N1P7Similarity: Contains 10 beta/gamma crystallin 'Greek key' domainsSimilarity: Contains 1 ricin B-type lectin domain |
Function
for AIM1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AIM1L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AIM1L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: AIM1L (NM_001039775) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AIM1L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIM1L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIM1L |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030246 | carbohydrate binding |
-- | -- |
AIM1L for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for AIM1L:
|
Pathways & Interactions
for AIM1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AIM1L
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for AIM1L (ENSP000004098344) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for AIM1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AIM1L
Search CenterWatch for drugs/clinical trials and news about AIM1L
|
Transcripts
for AIM1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AIM1L gene (2 alternative transcripts): NM_017977.2 NM_001039775.3 Unigene Cluster for AIM1L: Absent in melanoma 1-like Hs.128738 [show with all ESTs]Unigene Representative Sequence: NM_00103977512 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000527815(uc001bmd.4) ENST00000374211 ENST00000374208 ENST00000520372
ENST00000522923 ENST00000429942 ENST00000522993(uc001bmf.3) ENST00000374207
ENST00000475866 ENST00000308182 ENST00000449629 ENST00000538018
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AIM1L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AIM1L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AIM1L (NM_001039775) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AIM1L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIM1L |
Additional cDNA sequence: AK000902.1 AK095339.1 AL137264.1 BC136870.1 9 DOTS entries: DT.100018385 DT.40228093 DT.75151403 DT.91729949 DT.92416043 DT.95154969 DT.95231314 DT.121388528 DT.91753166 24/44 AceView cDNA sequences (see all 44): AA970836 CD628847 AK095339 C00439 AL137264 AA368531 BE900495 AI950844 CD628851 AU117258 BU196579 BQ690701 CD628849 NM_017977 BG740051 BX091937 BE746856 AI761793 CD628854 CD628850 CD628845 CD628852 BG742041 BG480289
GeneLoc Exon Structure
|
Expression
for AIM1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AIM1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCTACAGG
About this image
See AIM1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AIM1L
SOURCE GeneReport for Unigene cluster: Hs.128738
SABiosciences Custom PCR Arrays for AIM1L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AIM1L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AIM1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AIM1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AIM1L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIM1L |
Orthologs
for AIM1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for AIM1L gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for AIM1L (if available)
TreeFam Gene Tree for AIM1L (if available) |
Paralogs
for AIM1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AIM1L gene
- CRYBG32 AIM12
14 SIMAP similar genes for AIM1L using alignment to 7 protein entries: AIM1L_HUMAN (see all proteins):DKFZp434L1713 AIM1 CRYBB3 CRYGC CRYBG3 CRYBB2
CRYGB DKFZp434A0627 CRYGS CRYBA4 CRYGA CRYGD
CRYBB1 CRYBA1
AIM1L for paralogs About GeneDecksing
|
Genomic Variants
for AIM1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AIM1L (26648350 - 26680621 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AIM1L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AIM1L |
|
Disorders
/ Diseases
for AIM1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AIM1L for disorders About GeneDecksing
1  disease for AIM1L: About MalaCardsmelanoma
Human Genome Epidemiology (HuGE) Navigator: AIM1L (1 document)
Export disorders for AIM1L gene to outside databases
|
Publications
for AIM1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AIM1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with AIM1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. (PubMed id 17672918)1 Szafranski K....Platzer M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PubMed id 15203218)1 Fu G.K....Stuve L.L. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Cloning and tissue expression of the mouse ortholog of AIM1, a betagamma-crystallin superfamily member. (PubMed id 9716656)1 Teichmann U....Pavan W.J. (1998)
- Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library. (PubMed id 8401585)1 Adams M.D....Venter J.C. (1993)
|
External Searches for AIM1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AIM1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AIM1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AIM1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for AIM1L gene:
Search GeneIP for patents involving AIM1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AIM1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for AIM1L | | OriGene Custom Protein Services for AIM1L | | | OriGene Custom Immunoassay Development | | |
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 | | | AIM1L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIM1L |
|  |  |  | | | | Search ThermoFisher Antibodies for AIM1L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIM1L |
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