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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AIM1 Gene

protein-coding GIFtS: 50
GCID: GC06P106915

absent in melanoma 1

Explore 2 diseases affiliated with
AIM1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Absent In Melanoma 1¹ ²		Absent In Melanoma 1 Protein²
CRYBG1¹ ² ³		Beta-Gamma Crystallin Domain Containing 1²
ST4¹ ² ⁵		Suppression Of Tumorigenicity 4 (Malignant Melanoma)²
Beta/Gamma Crystallin Domain-Containing Protein 1² ³

External Ids:	HGNC: 356¹	Entrez Gene: 202²	Ensembl: ENSG00000112297⁷	OMIM: 601797⁵	UniProtKB: Q9Y4K1³

Export aliases for AIM1 gene to outside databases

Previous GC identifers: GC06P106795 GC06P106982 GC06P106955 GC06P106854 GC06P107066 GC06P104406

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: AIM1_HUMAN, Q9Y4K1

Function: May function as suppressor of malignant melanoma. It may exert its effects through interactions with the

cytoskeleton

Gene Wiki entry for AIM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AIM1 gene promoter:
HOXA9B HOXA9 NF-1 AML1a Tal-1 HTF Lmo2 CUTL1 E47 SRY
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AIM1 promoter sequence

Search SABiosciences Chromatin IP Primers for AIM1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AIM1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21

AIM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AIM1 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P106915: view genomic region (about GC identifiers)

Start:	106,959,730 bp from pter	End:	107,018,335 bp from pter
Size:	58,606 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AIM1_HUMAN, Q9Y4K1 (See protein sequence)

Recommended Name: Absent in melanoma 1 protein

Size: 1723 amino acids; 188676 Da

2 PDB 3D structures from and Proteopedia for AIM1:

2DAD (3D)

3CW3 (3D)

Secondary accessions: O00296 Q5VWJ2

Explore the universe of human proteins at neXtProt for AIM1: NX_Q9Y4K1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y4K1

AIM1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001615.1

ENSEMBL proteins:

ENSP00000358062 ENSP00000391419 ENSP00000439183

Human Recombinant Protein Products:

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	Uscn Proteins for AIM1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

AIM1 for ontologies About GeneDecksing

AIM1 Antibody Products:

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	Uscn ELISAs and CLIAs for AIM1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AIM1 for domains About GeneDecksing

3 InterPro domains/families:

IPR001064 Beta/gamma_crystallin

IPR000772 Ricin_B_lectin

IPR011024 G_crystallin-rel

Graphical View of Domain Structure for InterPro Entry Q9Y4K1

ProtoNet protein and cluster: Q9Y4K1

3 Blocks protein families:

IPB000772 Ricin B lectin domain

IPB001064 Beta and gamma crystallin

IPB011024 Gamma-crystallin related

UniProtKB/Swiss-Prot: AIM1_HUMAN, Q9Y4K1

Similarity: Belongs to the beta/gamma-crystallin family

Similarity: Contains 12 beta/gamma crystallin 'Greek key' domains

Similarity: Contains 1 ricin B-type lectin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: AIM1_HUMAN, Q9Y4K1

Function: May function as suppressor of malignant melanoma. It may exert its effects through interactions with the

cytoskeleton

Genatlas biochemistry entry for AIM1:

non-lens member of the beta-gamma crystallin superfamily,mitotic regulator playing a key role in the onset of

cytokinesis during mitosis,involved in the control of tumorigenicity in malignant melanoma

miRNA Products:		OriGene 3'-UTR Clone: AIM1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AIM1
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate AIM1 (see all 12):
		hsa-miR-320a hsa-miR-29c hsa-miR-29a hsa-miR-320d hsa-miR-16-1* hsa-miR-520a-5p hsa-miR-335 hsa-miR-649

		SwitchGear 3'UTR luciferase reporter plasmid: AIM1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for AIM1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		Search LifeMap BioReagents cell lines for AIM1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIM1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0030246	carbohydrate binding	--	--

AIM1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for AIM1

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/7 Interacting proteins for AIM1 (Q9Y4K1³ ENSP00000358062⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPS6KA3	P51812³	I2D: score=2
AURKB	ENSP00000313950⁴	STRING: ENSP00000313950
TACC1	ENSP00000321703⁴	STRING: ENSP00000321703
BIRC5	ENSP00000301633⁴	STRING: ENSP00000301633
INCENP	ENSP00000378295⁴	STRING: ENSP00000378295

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

AIM1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AIM1
Search CenterWatch for drugs/clinical trials and news about AIM1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AIM1 gene:

NM_001624.2

Unigene Clusters for AIM1:

Absent in melanoma 1

Hs.643590 [show with all ESTs], Hs.724262 [show with all ESTs]

Unigene Representative Sequences: NM_001624, AK125137

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369066(uc003prh.3 uc003pri.3) ENST00000457437 ENST00000487681

ENST00000535438

miRNA Products:		OriGene 3'-UTR Clone: AIM1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AIM1
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate AIM1 (see all 12):
		hsa-miR-320a hsa-miR-29c hsa-miR-29a hsa-miR-320d hsa-miR-16-1* hsa-miR-520a-5p hsa-miR-335 hsa-miR-649

		SwitchGear 3'UTR luciferase reporter plasmid: AIM1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AIM1 (see all 4) OriGene shRNA RFP: AIM1 OriGene siRNA: AIM1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AIM1

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		GenScript: all cDNA clones in your preferred vector: AIM1 (NM_001624)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for AIM1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIM1

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AIM1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AIM1

Additional cDNA sequence: AK125137.1

12 DOTS entries:

DT.316122 DT.101971314 DT.95173630 DT.91775040 DT.121313608 DT.86838658 DT.121313663 DT.91775048

DT.95173634 DT.101971914 DT.40294489 DT.95303148

24/211 AceView cDNA sequences (see all 211):

AA251228 BU631075 BX492888 AI065078 BE551949 AI973063 BX481229 AW272757

BF064175 AI064965 BE503311 CA424801 BU620267 BM824399 AI475399 CR601872

BF197960 AL550776 AI522011 BX955186 T53644 CR600498 AA765822 AA761127

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AIM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACAACAGCA

About this image

AIM1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Hyoid Arch Muscles

Myoblasts

Skeletal Muscle

Mandibular Arch Muscles

Myoblasts

Skeletal Muscle

Bone

Zeugopod Epiphyseal End

Bone

Kidney

Renal Collecting Duct System

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See AIM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AIM1

SOURCE GeneReport for Unigene clusters: Hs.643590 Hs.724262

SABiosciences Custom PCR Arrays for AIM1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AIM1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AIM1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIM1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for AIM1 gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	AIM1¹	absent in melanoma 1	62.12(n) 53.82(a)		421783 XM_419809.3 XP_419809.3
lizard (Anolis carolinensis)	Reptilia	-- --	--	61(a) 57(a)	1 ↔ many 1 ↔ many	1(189445388-189453006) 1(189407723-189441970)
African clawed frog (Xenopus laevis)	Amphibia	Xl.9757²	Xenopus laevis transcribed sequence with weak similarity more	71.84(n)		BJ060602.1
zebrafish (Danio rerio)	Actinopterygii	BQ259650.1²	--	70.03(n)		BQ259650.1

ENSEMBL Gene Tree for AIM1 (if available)
TreeFam Gene Tree for AIM1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for AIM1 gene

CRYBG3² AIM1L²

13 SIMAP similar genes for AIM1 using alignment to 4 protein entries: AIM1_HUMAN (see all proteins):

AIM1L DKFZp434L1713 CRYBG3 CRYGB CRYBA2 CRYBB3

CRYBB2 CRYBA1 CRYBA4 CRYGC CRYGD CRYGA

DKFZp434A0627

AIM1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35173941^1,2	C,	--	104459311(+)	`TGGGG-/CCTGAT`	1	--	int¹		1		NA	2
rs112313862^1,2	C	--	104459311(+)	`TGGGGG/CCTGAT`	1	--	int¹		1		CSA	2
rs710097^1,2	C,F,H,	--	106958021(-)	`AAACCT/CAGGTG`	1	--	us2k¹		28		NA EA NS WA CSA	3154
rs183810634^1,2		--	106958134(+)	`GCTGGA/GCTCGC`	1	--	us2k¹		0	--	--	--	--
rs114573780^1,2	F,	--	106958136(+)	`TGGGCT/CCGCCG`	1	--	us2k¹		2		WA NA	238
rs116520805^1,2	F,	--	106958246(+)	`CACCGC/AGCCCA`	1	--	us2k¹		1		WA	118
rs6929949^1,2	C,F,A,H,	--	106958518(+)	`CTTCAA/GCCACA`	1	--	us2k¹		13		NA WA EA	514
rs76157004^1,2		--	106958596(+)	`CACTCC/TTCCGT`	1	--	us2k¹		2		CSA WA	120
rs187579702^1,2		--	106958613(+)	`ATGGTA/GGGAAC`	1	--	us2k¹		0	--	--	--	--
rs139176758^1,2		--	106958652(+)	`CTCTGC/TAGCCG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for AIM1 (106959730 - 107018335 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for AIM1
2 CNVs: 99655 69582
5 Indels: 28054 62557 40898 42132 46964

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AIM1

DNA2.0 Custom Variant and Variant Library Synthesis for AIM1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

AIM1 for disorders           About GeneDecksing

OMIM gene information: 601797    OMIM disorders: --

2 diseases for AIM1:    About MalaCards

melanoma keratitis

Human Genome Epidemiology (HuGE) Navigator: AIM1 (30 documents)

Export disorders for AIM1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for AIM1 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with AIM1)

Utopia: connect your pdf to the dynamic
world of online information

Exploring the limits of sequence and structure in a variant betagamma-crystallin domain of the protein absent in melanoma-1 (AIM1). (PubMed id 18582473)^{1, 2} Aravind P.... Sankaranarayanan R. (2008)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Stability, homodimerization, and calcium-binding prop erties of a single, variant betagamma-crystallin domain of the protein absent i n melanoma 1 (AIM1). (PubMed id 12693952)^{1, 3} Rajini B....Sharma Y. (2003)
AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma. (PubMed id 9096375)^{1, 2} Ray M.E.... Trent J.M. (1997)
Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma. (PubMed id 1680551)^{1, 3} Millikin D....Trent J. (1991)
AIM1 promoter hypermethylation as a predictor of decre ased risk of recurrence following radical prostatectomy. (PubMed id 22127895)¹ Rosenbaum E....Hoque M.O. (2012)
High-throughput transcriptomic and RNAi analysis ident ifies AIM1, ERGIC1, TMED3 and TPX2 as potential drug targets in prostate cancer. (PubMed id 22761906)¹ Vainio P....Iljin K. (2012)
AIM1 and LINE-1 epigenetic aberrations in tumor and se rum relate to melanoma progression and disease outcome. (PubMed id 22402438)¹ Hoshimoto S....Hoon D.S. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 202	HGNC: 356	AceView: AIM1	Ensembl:ENSG00000112297	euGenes: HUgn202
ECgene: AIM1	H-InvDB: AIM1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for AIM1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for AIM1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for AIM1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for AIM1 gene:
Search GeneIP for patents involving AIM1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	Browse OriGene Antibodies		OriGene shRNA RFP for AIM1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AIM1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AIM1
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for AIM1		OriGene 3'-UTR Clone for AIM1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AIM1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AIM1
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	OriGene Custom Antibody Services for AIM1		OriGene Custom Protein Services for AIM1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AIM1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AIM1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AIM1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AIM1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AIM1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AIM1

	GenScript Custom Purified and Recombinant Proteins Services for AIM1		GenScript cDNA clones with any tag delivered in your preferred vector for AIM1
	GenScript Custom Assay Services for AIM1		GenScript Custom Superior Antibodies Services for AIM1
	GenScript Custom overexpressing Cell Line Services for AIM1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in AIM1 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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	Search for Antibodies for AIM1 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for AIM1
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AIM1 Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIM1

	SwitchGear 3'UTR luciferase reporter plasmids for AIM1
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Search ThermoFisher Antibodies for AIM1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIM1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes AIM1 gene at Home site.

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AIM1 Gene

absent in melanoma 1

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AIM1 Gene

absent in melanoma 1

Aliasesfor AIM1 gene

Summariesfor AIM1 gene

Genomic Viewsfor AIM1 gene

Proteinsfor AIM1 gene

Protein Domains /Familiesfor AIM1 gene

Functionfor AIM1 gene

Pathways & Interactionsfor AIM1 gene

Drugs & Compoundsfor AIM1 gene

Transcriptsfor AIM1 gene

Expression for AIM1 gene

Orthologsfor AIM1 gene

Paralogsfor AIM1 gene

Genomic Variantsfor AIM1 gene

Disorders / Diseasesfor AIM1 gene

Publicationsfor AIM1 gene

External Searches for AIM1 gene

Genome Databases showing AIM1 gene

Other Databases showing AIM1 gene

Specialized Databases showing AIM1 gene

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for AIM1 gene

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Families
for AIM1 gene

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for AIM1 gene

Pathways & Interactions
for AIM1 gene

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for AIM1 gene

Transcripts
for AIM1 gene

Expression
for AIM1 gene

Orthologs
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for AIM1 gene

Disorders / Diseases
for AIM1 gene

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for AIM1 gene

Intellectual Property
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