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Aliases for AIM1 Gene

Aliases for AIM1 Gene

  • Absent In Melanoma 1 2 3
  • Suppression Of Tumorigenicity 4 (Malignant Melanoma) 2 3
  • Beta/Gamma Crystallin Domain-Containing Protein 1 3 4
  • Beta-Gamma Crystallin Domain Containing 1 2 3
  • CRYBG1 3 4
  • ST4 3 6
  • Suppression Of Tumorigenicity 4 2
  • Absent In Melanoma 1 Protein 3

External Ids for AIM1 Gene

Previous HGNC Symbols for AIM1 Gene

  • ST4

Previous GeneCards Identifiers for AIM1 Gene

  • GC06P106795
  • GC06P106982
  • GC06P106955
  • GC06P106854
  • GC06P106915
  • GC06P107066
  • GC06P104406

Summaries for AIM1 Gene

GeneCards Summary for AIM1 Gene

AIM1 (Absent In Melanoma 1) is a Protein Coding gene. Diseases associated with AIM1 include albinism, oculocutaneous, type iv and melanoma. An important paralog of this gene is AIM1L.

UniProtKB/Swiss-Prot for AIM1 Gene

  • May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton

Gene Wiki entry for AIM1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AIM1 Gene

Genomics for AIM1 Gene

Regulatory Elements for AIM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AIM1 Gene

106,360,808 bp from pter
106,570,460 bp from pter
209,653 bases
Plus strand

Genomic View for AIM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AIM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AIM1 Gene

Proteins for AIM1 Gene

  • Protein details for AIM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Absent in melanoma 1 protein
    Protein Accession:
    Secondary Accessions:
    • B4DU04
    • O00296
    • Q5VWJ2

    Protein attributes for AIM1 Gene

    1723 amino acids
    Molecular mass:
    188676 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for AIM1 Gene

    Alternative splice isoforms for AIM1 Gene


neXtProt entry for AIM1 Gene

Proteomics data for AIM1 Gene at MOPED

Post-translational modifications for AIM1 Gene

  • Ubiquitination at Lys988
  • Modification sites at PhosphoSitePlus

Other Protein References for AIM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AIM1 Gene

Domains for AIM1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y4K1
  • Contains 12 beta/gamma crystallin Greek key domains.
  • Contains 1 ricin B-type lectin domain.
  • Belongs to the beta/gamma-crystallin family.
genes like me logo Genes that share domains with AIM1: view

No data available for Gene Families for AIM1 Gene

Function for AIM1 Gene

Molecular function for AIM1 Gene

GENATLAS Biochemistry:
non-lens member of the beta-gamma crystallin superfamily,mitotic regulator playing a key role in the onset of cytokinesis during mitosis,involved in the control of tumorigenicity in malignant melanoma
UniProtKB/Swiss-Prot Function:
May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton

Gene Ontology (GO) - Molecular Function for AIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with AIM1: view

Animal Model Products

miRNA for AIM1 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AIM1 Gene

Localization for AIM1 Gene

Subcellular locations from

Jensen Localization Image for AIM1 Gene COMPARTMENTS Subcellular localization image for AIM1 gene
Compartment Confidence
nucleus 3
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with AIM1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for AIM1 Gene

Pathways for AIM1 Gene

SuperPathways for AIM1 Gene

No Data Available

Interacting Proteins for AIM1 Gene

Gene Ontology (GO) - Biological Process for AIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with AIM1: view

No data available for Pathways by source for AIM1 Gene

Transcripts for AIM1 Gene

mRNA/cDNA for AIM1 Gene

Unigene Clusters for AIM1 Gene

Absent in melanoma 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AIM1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AIM1 Gene

No ASD Table

Relevant External Links for AIM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AIM1 Gene

mRNA expression in normal human tissues for AIM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AIM1 Gene

This gene is overexpressed in Esophagus - Mucosa (10.3).

Protein differential expression in normal tissues for AIM1 Gene

This gene is overexpressed in Cervix (32.4), Lymph node (9.8), and Peripheral blood mononuclear cells (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AIM1 Gene

SOURCE GeneReport for Unigene cluster for AIM1 Gene Hs.724262

genes like me logo Genes that share expressions with AIM1: view

Expression partners for AIM1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AIM1 Gene

Orthologs for AIM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AIM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AIM1 35
  • 85.87 (n)
  • 81.17 (a)
AIM1 36
  • 80 (a)
(Canis familiaris)
Mammalia AIM1 35
  • 81.85 (n)
  • 77.68 (a)
AIM1 36
  • 76 (a)
(Mus musculus)
Mammalia Aim1 35
  • 81.05 (n)
  • 77.96 (a)
Aim1 16
Aim1 36
  • 77 (a)
(Pan troglodytes)
Mammalia AIM1 35
  • 99.23 (n)
  • 98.67 (a)
AIM1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Aim1 35
  • 79.87 (n)
  • 76.76 (a)
(Monodelphis domestica)
Mammalia AIM1 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia AIM1 36
  • 57 (a)
(Gallus gallus)
Aves AIM1 35
  • 64.93 (n)
  • 57.18 (a)
AIM1 36
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
-- 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia aim1 35
  • 58.67 (n)
  • 50.65 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9757 35
(Danio rerio)
Actinopterygii aim1a 36
  • 17 (a)
aim1b 36
  • 36 (a)
Species with no ortholog for AIM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AIM1 Gene

Gene Tree for AIM1 (if available)
Gene Tree for AIM1 (if available)

Paralogs for AIM1 Gene

Paralogs for AIM1 Gene

Selected SIMAP similar genes for AIM1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AIM1: view

Variants for AIM1 Gene

Sequence variations from dbSNP and Humsavar for AIM1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1784 -- 106,471,656(-) ACCTT(C/G)TTGTT intron-variant
rs8013 -- 106,570,279(+) GTTTT(A/C)AAATA utr-variant-3-prime
rs8910 -- 106,570,260(+) CACTG(A/G)AATAG utr-variant-3-prime
rs11682 -- 106,570,422(+) GATCT(C/T)TTAAA utr-variant-3-prime
rs13319 -- 106,569,779(+) GTTCT(A/G)CAGCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for AIM1 Gene

Variant ID Type Subtype PubMed ID
esv26399 CNV Gain 19812545
esv2481074 CNV Deletion 19546169
esv2278880 CNV Deletion 18987734
esv5031 CNV Deletion 18987735
esv2732540 CNV Deletion 23290073
esv1180121 CNV Deletion 17803354
esv6147 CNV Loss 19470904
esv2671128 CNV Deletion 23128226
esv2732541 CNV Deletion 23290073
esv2732542 CNV Deletion 23290073
esv2732543 CNV Deletion 23290073

Relevant External Links for AIM1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AIM1 Gene

Disorders for AIM1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for AIM1 Gene in MalaCards »

(2) Diseases for AIM1 Gene including...

Relevant External Links for AIM1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with AIM1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for AIM1 Gene

Publications for AIM1 Gene

  1. Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma. (PMID: 1680551) Millikin D. … Trent J. (Cancer Res. 1991) 2 3
  2. AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma. (PMID: 9096375) Ray M.E. … Trent J.M. (Proc. Natl. Acad. Sci. U.S.A. 1997) 3 4
  3. Stability, homodimerization, and calcium-binding properties of a single, variant betagamma-crystallin domain of the protein absent in melanoma 1 (AIM1). (PMID: 12693952) Rajini B. … Sharma Y. (Biochemistry 2003) 2 3
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for AIM1 Gene

Sources for AIM1 Gene

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