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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AIG1 Gene

protein-coding   GIFtS: 55
GCID: GC06P143423

Androgen-Induced 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Androgen-Induced 11 2
AIG-12 3
Androgen-Induced Gene 1 Protein2
dJ95L4.12

External Ids:    HGNC: 216071   Entrez Gene: 513902   Ensembl: ENSG000001464167   OMIM: 6085145   UniProtKB: Q9NVV53   

Export aliases for AIG1 gene to outside databases

Previous GC identifers: GC06P143315 GC06P143362 GC06P140946


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AIG1 Gene: 
AIG1 (androgen-induced 1) is a protein-coding gene. Diseases associated with AIG1 include amebiasis, and prostate cancer. GO annotations related to this gene include protein binding. An important paralog of this gene is ADTRP.

UniProtKB/Swiss-Prot: AIG1_HUMAN, Q9NVV5
Function: May play a role in androgen-regulated growth of hair follicles

Gene Wiki entry for AIG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AIG1 gene promoter:
         c-Fos   AP-1   AML1a   JunB   Fra-1   FosB   HNF-3beta   PPAR-gamma1   JunD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAIG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AIG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AIG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24.2   Ensembl cytogenetic band:  6q24.2   HGNC cytogenetic band: 6q24.1

AIG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AIG1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P143423:  view genomic region     (about GC identifiers)

Start:
143,381,633 bp from pter      End:
143,661,441 bp from pter
Size:
279,809 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AIG1_HUMAN, Q9NVV5 (See protein sequence)
Recommended Name: Androgen-induced gene 1 protein  
Size: 245 amino acids; 28222 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAD34098.1; Type=Frameshift; Positions=182, 193, 223; Sequence=CAE45823.1;
Type=Erroneous initiation;
Secondary accessions: Q5T2H2 Q6N047 Q7Z378 Q8TB14 Q9Y3A9 Q9Y5B4
Alternative splicing: 5 isoforms:  Q9NVV5-1   Q9NVV5-2   Q9NVV5-3   Q9NVV5-4   Q9NVV5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AIG1: NX_Q9NVV5

Explore proteomics data for AIG1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NVV5

  • AIG1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AIG1 Protein Expression
    REFSEQ proteins: NP_057192.2  
    ENSEMBL proteins: 
     ENSP00000356573   ENSP00000405048   ENSP00000350509   ENSP00000356568   ENSP00000473952  
     ENSP00000275235   ENSP00000407817   ENSP00000340090   ENSP00000356570  

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    Cloud-Clone Corp. Proteins for AIG1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    AIG1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006838 Far-17a_AIG1

    Graphical View of Domain Structure for InterPro Entry Q9NVV5

    ProtoNet protein and cluster: Q9NVV5

    UniProtKB/Swiss-Prot: AIG1_HUMAN, Q9NVV5
    Similarity: Belongs to the AIG1 family


    AIG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AIG1_HUMAN, Q9NVV5
    Function: May play a role in androgen-regulated growth of hair follicles
    Induction: By dihydrotestosterone (DHT)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    AIG1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AIG1:
     Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AIG1 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AIG1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for AIG1 (Q9NVV51, 3 ENSP000003505094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RCHY1Q96PM51, ENSP000003212394EBI-3942989,EBI-947779 STRING: ENSP00000321239
    PAHP004393I2D: score=5 
    NAPBQ9H1153I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AIG1

    Search CenterWatch for drugs/clinical trials and news about AIG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AIG1 gene: 
    NM_016108.2  

    Unigene Cluster for AIG1:

    Androgen-induced 1
    Hs.567501  [show with all ESTs]
    Unigene Representative Sequence: BX640703
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367601 ENST00000447498 ENST00000357847(uc003qjf.3 uc003qjh.3)
    ENST00000367596 ENST00000494282 ENST00000275235 ENST00000458219 ENST00000470265
    ENST00000344492(uc003qji.3) ENST00000367598(uc011edw.1 uc003qjg.3)

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate AIG1:
    hsa-miR-1304 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidAIG1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF151861.1 AF153605.1 AJ420480.1 AK001347.1 AK222475.1 AK298533.1 BC009559.2 BC025278.1 
    BX538067.1 BX640703.1 

    22 DOTS entries:

    DT.445471  DT.211906  DT.100787866  DT.452255  DT.100787865  DT.92443985  DT.100787863  DT.100787864 
    DT.100001165  DT.100726890  DT.101956094  DT.121349389  DT.121349511  DT.451690  DT.97843388  DT.100787859 
    DT.121349400  DT.40211691  DT.92443979  DT.100787861  DT.92414602  DT.92443987 

    24/248 AceView cDNA sequences (see all 248):

    BM354179 CA431282 AW014881 AK001347 AA470011 BQ438989 CN478707 AA922304 
    BU732887 AW086141 AL550068 AI248277 BC025278 NM_016108 AA412262 BQ011512 
    AA635600 BU630292 BX538067 BM455949 AW450977 BU621956 CR604536 AA814510 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for AIG1    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:        -                 -                 -                     
    SP2:                          -                 -                     
    SP3:                          -     -           -                     
    SP4:                          -                                       
    SP5:                                                                  


    ECgene alternative splicing isoforms for AIG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AIG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAACTTTT
    AIG1 Expression
    About this image


    See AIG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AIG1

    SOURCE GeneReport for Unigene cluster: Hs.567501

    UniProtKB/Swiss-Prot: AIG1_HUMAN, Q9NVV5
    Tissue specificity: Highly expressed in heart, ovary, testis, liver, and kidney, at lower levels in spleen,
    prostate, brain, skeletal muscle, pancreas, small intestine and colon, and undetected in peripheral blood
    leukocytes, thymus, lung and placenta. AIG1 expression is higher in hair follicles from males than from females

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for AIG1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aig11 , 5 androgen-induced 11, 5 88.99(n)1
    95.15(a)1
      10 (5.08 cM)5
    662531  NM_025446.31  NP_079722.11 
     136470545 
    chicken
    (Gallus gallus)
    Aves AIG11 androgen-induced 1 79.83(n)
    82.77(a)
      421671  XM_419710.3  XP_419710.2 
    lizard
    (Anolis carolinensis)
    Reptilia AIG16
    Uncharacterized protein
    77(a)
    1 ↔ 1
    1(203687209-203817516)
    African clawed frog
    (Xenopus laevis)
    Amphibia BG345433.12   -- 69.84(n)    BG345433.1 
    zebrafish
    (Danio rerio)
    Actinopterygii aig11 androgen-induced 1 (H. sapiens) 70.09(n)
    74.79(a)
      562261  XM_685654.3  XP_690746.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG36251 CG3625 51.56(n)
    38.92(a)
      33198  NM_164378.1  NP_722622.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C37E2.26
    C37E2.36
    Protein C37E2.3
    21(a)
    16(a)
    many ↔ many
    many ↔ many
    X(14176050-14178471)
    X(14178988-14181705)


    ENSEMBL Gene Tree for AIG1 (if available)
    TreeFam Gene Tree for AIG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AIG1 gene
    ADTRP2  
    1 SIMAP similar gene for AIG1 using alignment to 6 protein entries:     AIG1_HUMAN (see all proteins):
    ADTRP

    AIG1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for AIG1
    PGOHUM00000235567


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5398 SNPs in AIG1 are shown (see all 5398)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1910760511,2
    --143380036(+) ATCACA/TTTAAC 1 -- us2k10--------
    rs1468277291,2
    --143380263(+) GAGGAC/TTGAAA 1 -- us2k10--------
    rs18555601,2
    C,F,A--143380280(-) CTATGA/GGAGTG 1 -- us2k16Minor allele frequency- G:0.21WA CSA NA EA 364
    rs1405813711,2
    C--143380283(+) TCTCAC/TAGGAC 1 -- us2k10--------
    rs754642241,2
    --143380377(+) CATGCC/TGTGGA 1 -- us2k10--------
    rs1174436191,2
    F--143380422(+) CTATCG/ACTCAC 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1162280051,2
    C,F--143380479(+) TCTGCC/TGCTTC 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs13344771,2
    C,F--143380517(-) CCTGCC/TGGTAG 1 -- us2k13Minor allele frequency- T:0.14WA NA EA 358
    rs117564891,2
    H--143380580(+) TTTTTA/TATTTT 1 -- us2k1 tfbs30--------
    rs117586711,2
    H--143380587(+) TTTTTA/TTTTTT 1 -- us2k1 tfbs30--------

    HapMap Linkage Disequilibrium report for AIG1 (143381633 - 143631633 bp, first 250kb of AIG1)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for AIG1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664367CNV Deletion23128226
    esv2659568CNV Deletion23128226
    esv29171CNV Loss19812545
    esv275228CNV Gain+Loss21479260

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608514    OMIM disorders: --

    3 diseases for AIG1:    About MalaCards
    amebiasis    prostate cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for AIG1:
    Amebiasis

    AIG1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AIG1
    Human Genome Epidemiology (HuGE) Navigator: AIG1 (1 document)

    Export disorders for AIG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AIG1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with AIG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of androgen-inducible gene 1 (AIG1) from human dermal papilla cells. (PubMed id 11266118)1, 2, 3, 9 Seo J.... Kim M. (2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    7. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    8. AIG1 is a novel Pirh2-interacting protein that activa tes the NFAT signaling pathway. (PubMed id 21622095)1 Wu G....Huo K. (2011)
    9. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PubMed id 17903298)4 Meigs J.B....Dupuis J. (2007)
    10. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51390 HGNC: 21607 AceView: AIG1 Ensembl:ENSG00000146416 euGenes: HUgn51390
    ECgene: AIG1 H-InvDB: AIG1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AIG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AIG1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AIG1 gene:
    Search GeneIP for patents involving AIG1

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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