AIG1 Gene
protein-coding GIFtS: 52
GCID: GC06P143423
|
|
androgen-induced 1
| |
Aliases
for AIG1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Androgen-Induced 11 2 | | AIG-11 2 3 | | DJ95L4.11 | | FLJ104851 | | Androgen-Induced Gene 1 Protein2 |
Export aliases for AIG1 gene to outside databasesPrevious GC identifers: GC06P143315 GC06P143362 GC06P140946 |
Summaries
for AIG1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AIG1_HUMAN, Q9NVV5Function: May play a role in androgen-regulated growth of hair follicles
Gene Wiki entry for AIG1
|
Genomic Views
for AIG1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AIG1 gene promoter:
c-Fos AP-1 AML1a JunB Fra-1 FosB HNF-3beta PPAR-gamma1 JunD c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for AIG1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AIG1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q24.2 Ensembl cytogenetic band: 6q24.2 HGNC cytogenetic band: 6q24.1AIG1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P143423: view genomic region
(about GC identifiers)
Start:
|
143,381,633 bp from pter |
End:
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143,661,441 bp from pter |
Size:
|
279,809 bases |
Orientation:
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plus strand |
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Proteins
for AIG1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AIG1_HUMAN, Q9NVV5 (See
protein sequence)Recommended Name: Androgen-induced gene 1 protein Size: 245 amino acids; 28222 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAD34098.1; Type=Frameshift; Positions=182, 193, 223; Sequence=CAE45823.1; Type=Erroneousinitiation;
Secondary accessions: Q5T2H2 Q6N047 Q7Z378 Q8TB14 Q9Y3A9 Q9Y5B4Alternative splicing: 5 isoforms: Q9NVV5-1 Q9NVV5-2 Q9NVV5-3 Q9NVV5-4 Q9NVV5-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for AIG1: NX_Q9NVV5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NVV5
AIG1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057192.2
ENSEMBL proteins: ENSP00000356573 ENSP00000405048 ENSP00000350509 ENSP00000356568 ENSP00000275235 ENSP00000407817 ENSP00000340090 ENSP00000356570
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
AIG1 for ontologies About GeneDecksing
AIG1 Antibody Products:
Assay Products for AIG1: |
Protein
Domains /
Families
for AIG1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AIG1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NVV5ProtoNet protein and cluster: Q9NVV5 UniProtKB/Swiss-Prot: AIG1_HUMAN, Q9NVV5Similarity: Belongs to the AIG1 family |
Function
for AIG1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AIG1_HUMAN, Q9NVV5Function: May play a role in androgen-regulated growth of hair folliclesInduction: By dihydrotestosterone (DHT)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AIG1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AIG1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: AIG1 (NM_016108) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AIG1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIG1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIG1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
AIG1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for AIG1:
|
Pathways & Interactions
for AIG1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AIG1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for AIG1 (Q9NVV51, 3 ENSP000003505094) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for AIG1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AIG1
Search CenterWatch for drugs/clinical trials and news about AIG1
|
Transcripts
for AIG1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AIG1 gene: NM_016108.2 Unigene Cluster for AIG1: Androgen-induced 1 Hs.567501 [show with all ESTs]Unigene Representative Sequence: BX64070310 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367601 ENST00000447498 ENST00000357847(uc003qjf.3 uc003qjh.3)
ENST00000367596 ENST00000275235 ENST00000458219 ENST00000470265 ENST00000494282
ENST00000344492(uc003qji.3) ENST00000367598(uc011edw.1 uc003qjg.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AIG1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AIG1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AIG1 (NM_016108) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AIG1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIG1 |
Additional cDNA sequence: AF151861.1 AF153605.1 AJ420480.1 AK001347.1 AK222475.1 AK298533.1 BC009559.2 BC025278.1 BX538067.1 BX640703.1 22 DOTS entries: DT.445471 DT.211906 DT.100787866 DT.452255 DT.100787865 DT.92443985 DT.100787863 DT.100787864 DT.100001165 DT.100726890 DT.101956094 DT.121349389 DT.121349511 DT.451690 DT.97843388 DT.100787859 DT.121349400 DT.40211691 DT.92443979 DT.100787861 DT.92414602 DT.92443987 24/248 AceView cDNA sequences (see all 248): BU621956 AW450977 BM455949 BX538067 AA635600 BU630292 BQ011512 NM_016108 AA412262 BC025278 R46017 AL550068 AI248277 BX281942 BU686203 BG182810 CR594659 T39897 BU616883 CA418743 AA193549 CD677179 BU619501 CR604536
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for AIG1 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
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| SP1: | | | - | | | | | | - | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | - | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for AIG1
|
Expression
for AIG1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AIG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAACTTTT
About this image
See AIG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AIG1
SOURCE GeneReport for Unigene cluster: Hs.567501
UniProtKB/Swiss-Prot: AIG1_HUMAN, Q9NVV5Tissue specificity: Highly expressed in heart, ovary, testis, liver, and kidney, at lower levels in spleen, prostate,brain, skeletal muscle, pancreas, small intestine and colon, and undetected in peripheral blood leukocytes, thymus,lung and placenta. AIG1 expression is higher in hair follicles from males than from females
SABiosciences Custom PCR Arrays for AIG1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AIG1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AIG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AIG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AIG1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIG1 |
Orthologs
for AIG1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for AIG1 gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for AIG1 (if available)
TreeFam Gene Tree for AIG1 (if available) |
Paralogs
for AIG1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AIG1 gene
- ADTRP2
1 SIMAP similar gene for AIG1 using alignment to 6 protein entries: AIG1_HUMAN (see all proteins):ADTRP
AIG1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for AIG1
PGOHUM00000235567
|
Genomic Variants
for AIG1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AIG1 (143381633 - 143631633 bp, first 250kb of AIG1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for AIG1
2 CNVs: 69608 94071
2 Indels: 81619 81618 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AIG1 |
|
Disorders
/ Diseases
for AIG1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AIG1 for disorders About GeneDecksing
OMIM gene information: 608514
OMIM disorders: --
3  diseases for AIG1: About MalaCardsamebiasis prostate cancer prostatitis
1 disease from the University of Copenhagen DISEASES database for AIG1:Amebiasis Human Genome Epidemiology (HuGE) Navigator: AIG1 (1 document)
Export disorders for AIG1 gene to outside databases
|
Publications
for AIG1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AIG1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with AIG1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of androgen-inducible gene 1 (AIG1) from human dermal papilla cells. (PubMed id 11266118)1, 2, 3, 9 Seo J.... Kim M. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
- AIG1 is a novel Pirh2-interacting protein that activa tes the NFAT signaling pathway. (PubMed id 21622095)1 Wu G....Huo K. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for AIG1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AIG1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AIG1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AIG1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for AIG1 gene:
Search GeneIP for patents involving AIG1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AIG1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for AIG1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AIG1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AIG1 | | | OriGene Protein Over-expression Lysate for AIG1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AIG1 | | OriGene 3'-UTR Clone for AIG1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AIG1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AIG1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AIG1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AIG1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AIG1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AIG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AIG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AIG1 |
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| | | | Search Tocris compounds for AIG1 |
| |  |  |  |  | | | | |
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 | | | AIG1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIG1 |
|  |  |  | | | | ThermoFisher Antibodies for AIG1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIG1 |
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