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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AIFM3 Gene

protein-coding   GIFtS: 54
GCID: GC22P021326

Apoptosis-Inducing Factor, Mitochondrion-Associated, 3

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Apoptosis-Inducing Factor, Mitochondrion-Associated, 31 2
AIFL2 3
Apoptosis-Inducing Factor 32
Apoptosis-Inducing Factor Like2
EC 1.-.-.-3
Apoptosis-Inducing Factor-Like Protein3

External Ids:    HGNC: 263981   Entrez Gene: 1502092   Ensembl: ENSG000001837737   UniProtKB: Q96NN93   
ORGUL members:         
NONCODE14:n407897      

Export aliases for AIFM3 gene to outside databases

Previous GC identifers: GC22P019649 GC22P021321 GC22P004589 GC22P021322


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AIFM3 Gene: 
AIFM3 (apoptosis-inducing factor, mitochondrion-associated, 3) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with AIFM3 include pneumonia, and tuberculosis. GO annotations related to this gene include oxidoreductase activity and cysteine-type endopeptidase activator activity involved in apoptotic process. An important paralog of this gene is AIFM1.

UniProtKB/Swiss-Prot: AIFM3_HUMAN, Q96NN9
Function: Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AIFM3 gene promoter:
         POU2F1   POU2F1b   POU2F1a   Pax-4a   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): AIFM3 promoter sequence
   Search SABiosciences Chromatin IP Primers for AIFM3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AIFM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

AIFM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AIFM3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P021326:  view genomic region     (about GC identifiers)

Start:
21,319,396 bp from pter      End:
21,335,649 bp from pter
Size:
16,254 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AIFM3_HUMAN, Q96NN9 (See protein sequence)
Recommended Name: Apoptosis-inducing factor 3  
Size: 605 amino acids; 66791 Da
Subcellular location: Mitochondrion. Note=Does not translocate to the nucleus upon induction of apoptosis
Secondary accessions: B7WP37 D3DX37 D3DX38 Q6ZT44 Q8N1V3 Q8N5E0
Alternative splicing: 3 isoforms:  Q96NN9-1   Q96NN9-2   Q96NN9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AIFM3: NX_Q96NN9

Explore proteomics data for AIFM3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96NN9

  • AIFM3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AIFM3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001018070.1  NP_001139760.1  NP_653305.1  

    ENSEMBL proteins: 
     ENSP00000382120   ENSP00000382116   ENSP00000412973   ENSP00000402067   ENSP00000399657  
     ENSP00000406989   ENSP00000385800   ENSP00000335369   ENSP00000390798   ENSP00000327671  

    Human Recombinant Protein Products for AIFM3: 
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    Novus Biologicals AIFM3 Proteins
    Novus Biologicals AIFM3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AIFM3 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634NOT nucleus IDA15764604
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IDA15764604
    GO:0005783endoplasmic reticulum IDA15764604

    AIFM3 for ontologies           About GeneDecksing



    AIFM3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR000103 Pyridine_nuc-diS_OxRdtase_2
     IPR013027 FAD_pyr_nucl-diS_OxRdtase
     IPR017941 Rieske_2Fe-2S
     IPR004099 Pyr_nucl-diS_OxRdtase_dimer
     IPR016156 FAD/NAD-linked_Rdtase_dimer

    Graphical View of Domain Structure for InterPro Entry Q96NN9

    ProtoNet protein and cluster: Q96NN9

    3 Blocks protein domains:
    IPB001327 Pyridine nucleotide-disulphide oxidoreductase
    IPB005806 Rieske [2Fe-2S] domain
    IPB013027 FAD-dependent pyridine nucleotide reductase signature


    UniProtKB/Swiss-Prot: AIFM3_HUMAN, Q96NN9
    Domain: The Rieske domain induces apoptosis
    Similarity: Belongs to the FAD-dependent oxidoreductase family
    Similarity: Contains 1 Rieske domain


    AIFM3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AIFM3_HUMAN, Q96NN9
    Function: Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential

         Enzyme Number (IUBMB): EC 1.-.-.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016491oxidoreductase activity IEA--
    GO:0046872metal ion binding IEA--
    GO:0050660flavin adenine dinucleotide binding IEA--
    GO:00515372 iron, 2 sulfur cluster binding IEA--
         
    AIFM3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for AIFM3:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AIFM3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AIFM3

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    hsa-miR-922 hsa-miR-1271 hsa-miR-590-3p hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidAIFM3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIFM3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AIFM3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for AIFM3 (Q96NN93 ENSP000003353694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLHL12Q53G593I2D: score=1 
    MAGEA11P433643I2D: score=1 
    PRNPP041563I2D: score=1 
    --ENSP000003687484STRING: ENSP00000368748
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process ----
    GO:0022900electron transport chain ----
    GO:0045454cell redox homeostasis IEA--
    GO:0055114oxidation-reduction process ----
    GO:0097194execution phase of apoptosis IDA15764604

    AIFM3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AIFM3

    1 HMDB Compound for AIFM3    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--

    Search CenterWatch for drugs/clinical trials and news about AIFM3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AIFM3 gene (3 alternative transcripts): 
    NM_001018060.2  NM_001146288.1  NM_144704.2  

    Unigene Cluster for AIFM3:

    Apoptosis-inducing factor, mitochondrion-associated, 3
    Hs.723246  [show with all ESTs]
    Unigene Representative Sequence: NM_001146288
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000399167(uc002ztk.2 uc002ztj.2) ENST00000399163 ENST00000417515
    ENST00000467926 ENST00000441376 ENST00000479523 ENST00000472575 ENST00000495869
    ENST00000434714 ENST00000426113 ENST00000468124 ENST00000484206 ENST00000405089(uc002ztl.2 uc011ahx.1)
    ENST00000496097 ENST00000465606 ENST00000483107 ENST00000486003 ENST00000335375

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate AIFM3:
    hsa-miR-922 hsa-miR-1271 hsa-miR-590-3p hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidAIFM3 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AIFM3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AIFM3

    Additional mRNA sequence: 

    AK055035.1 AK094844.1 AK295581.1 AK316042.1 BC032485.1 CR456342.1 NR_027464.1 

    14 DOTS entries:

    DT.100779185  DT.100648655  DT.40213016  DT.423376  DT.120667986  DT.95270268  DT.120668195  DT.100809547 
    DT.95270269  DT.100662270  DT.120668185  DT.120668326  DT.97816117  DT.99949405 

    24/206 AceView cDNA sequences (see all 206):

    BU192087 BU734421 CA489669 CR601558 BM697448 BQ019651 BF196818 BU735647 
    AA715048 CR600642 BM562885 BM562907 AL119038 NM_006767 BM783725 BM765038 
    AI569609 BQ427630 BU733514 BX279857 BE673452 AL833698 BQ182728 AI453247 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for AIFM3 (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^
    SP1:                                                              -     -     -     -     -                                                                     
    SP2:              -     -     -     -           -                 -     -     -     -     -                                                                     
    SP3:                                                                                                                                -                           
    SP4:                                            -                 -     -     -     -     -                                                                     
    SP5:                                                                                                                                                            

    ExUns: 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23
    SP1:                    -                                         -         
    SP2:                    -                                         -         
    SP3:                    -                                                   
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for AIFM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AIFM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAGACATTA
    AIFM3 Expression
    About this image


    See AIFM3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AIFM3

    SOURCE GeneReport for Unigene cluster: Hs.723246

    UniProtKB/Swiss-Prot: AIFM3_HUMAN, Q96NN9
    Tissue specificity: Ubiquitous. Expressed in bone marrow, cerebral cortex, liver, ovary, thymus, thyroid gland and
    tongue (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Array including AIFM3: 
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIFM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AIFM3 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aifm31 , 5 apoptosis-inducing factor, mitochondrion-associated more1, 5 87.96(n)1
    96.15(a)1
      16 (10.84 cM)5
    721681  NM_175178.31  NP_780387.21 
     174896115 
    chicken
    (Gallus gallus)
    Aves AIFM31 apoptosis-inducing factor, mitochondrion-associated, more 76.48(n)
    80.94(a)
      416999  XM_003642216.1  XP_003642264.1 
    lizard
    (Anolis carolinensis)
    Reptilia AIFM36
    apoptosis-inducing factor, mitochondrion-associate...
    67(a)
    1 ↔ 1
    GL343417.1(814741-829622)
    African clawed frog
    (Xenopus laevis)
    Amphibia nfrl-A2 neurula-specific ferredoxin reductase-like protein 73.75(n)    D86491.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ479502.12   -- 69.8(n)    BQ479502.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG107001 CG10700 50.1(n)
    38.1(a)
      35183  NM_136098.2  NP_609942.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F20D6.111 Protein F20D6.11 43.99(n)
    34.3(a)
      179196  NM_072711.3  NP_505112.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MDHAR1 monodehydroascorbate reductase (NADH) 43.08(n)
    28.41(a)
      820155  NM_111829.3  NP_566361.1 


    ENSEMBL Gene Tree for AIFM3 (if available)
    TreeFam Gene Tree for AIFM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AIFM3 gene
    AIFM12  

    AIFM3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/577 SNPs in AIFM3 are shown (see all 577)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57615671,2
    C,F,A,H--4588615(+) CTGGGT/CTCCAA 2 -- us2k19Minor allele frequency- C:0.31WA NA CSA EA 368
    rs60050611,2
    C,F,A,H--4588822(+) GGAAGT/CGGGCA 2 -- us2k15Minor allele frequency- C:0.25NA WA CSA 8
    rs671559901,2
    C--4588826(+) GCGGGCAGGGC  
     TGAAC
    /-
    CAGGG
    2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs57615691,2
    C,F,A,H--4588867(+) GGGACT/AGCCTA 2 -- us2k19Minor allele frequency- A:0.32WA NA CSA EA 368
    rs1926719771,2
    --4588890(+) GGGGCA/TGGTGG 2 -- us2k10--------
    rs119129741,2
    C,H--4588901(+) GGCAGA/GTGGCA 2 -- us2k10--------
    rs57615701,2
    C,F,A,H--4588958(+) AAGGCG/ACGCCC 2 -- us2k111Minor allele frequency- A:0.31MN EA WA NA CSA 1620
    rs57615711,2
    C,A,H--4589000(+) TGTAAT/CGGGCA 2 -- us2k16Minor allele frequency- C:0.27NA WA EA 542
    rs1169629941,2
    --4589212(+) GTGGGG/TAGGTC 2 -- us2k11Minor allele frequency- T:0.01EA 120
    rs175552581,2
    C,F--4589241(+) TTATGC/GCTGTG 2 -- us2k14Minor allele frequency- G:0.05MN EA NA 1492

    HapMap Linkage Disequilibrium report for AIFM3 (21319396 - 21335649 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for AIFM3 (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678175CNV Deletion23128226
    nsv436864CNV Insertion17901297
    nsv914425CNV Loss21882294
    dgv4873n71CNV Loss21882294
    nsv834141CNV Loss17160897
    nsv520145CNV Loss19592680
    nsv523162CNV Loss19592680
    nsv828960CNV Loss20364138
    dgv4872n71CNV Loss21882294
    nsv914424CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for AIFM3:    About MalaCards
    pneumonia    tuberculosis    gastric cancer    cerebritis
    thyroiditis


    AIFM3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AIFM3
    Human Genome Epidemiology (HuGE) Navigator: AIFM3 (1 document)

    Export disorders for AIFM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AIFM3 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with AIFM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a human AIF-like gene with ability to induce apoptosis. (PubMed id 15764604)1, 2, 3, 9 Xie Q.... Bonanno J.A. (2005)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    6. Downregulation of miR-210 expression inhibits prolifer ation, induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro. (PubMed id 22387901)1 Yang W....Zhu W. (2012)
    7. [Expression of AIF and CGRP markers in pineal gland an d thymus during aging]. (PubMed id 22550867)1 Lin'kova N.S....Khavinson V.K.h. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Protein microarray analysis identifies human cellular prion protein interactors. (PubMed id 18482256)1 Satoh J....Tabunoki H. (2009)
    10. H. pylori-induced apoptosis in human gastric cancer cells mediated via the release of apoptosis-inducing factor from mitochondria. (PubMed id 19166416)1 Ashktorab H....Smoot D.T. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 150209 HGNC: 26398 AceView: LZTR1andFLJ30473 Ensembl:ENSG00000183773 euGenes: HUgn150209
    ECgene: AIFM3 H-InvDB: AIFM3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AIFM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AIFM3 gene:
    Search GeneIP for patents involving AIFM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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