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Aliases for AIFM3 Gene

Aliases for AIFM3 Gene

  • Apoptosis-Inducing Factor, Mitochondrion-Associated, 3 2 3
  • AIFL 3 4
  • Apoptosis-Inducing Factor-Like Protein 4
  • Apoptosis-Inducing Factor Like 3
  • Apoptosis-Inducing Factor 3 3
  • EC 1.-.-.- 4

External Ids for AIFM3 Gene

Previous GeneCards Identifiers for AIFM3 Gene

  • GC22P019649
  • GC22P021321
  • GC22P004589
  • GC22P021322
  • GC22P021326
  • GC22P021355

Summaries for AIFM3 Gene

GeneCards Summary for AIFM3 Gene

AIFM3 (Apoptosis-Inducing Factor, Mitochondrion-Associated, 3) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and 2 iron, 2 sulfur cluster binding. An important paralog of this gene is AIFM1.

UniProtKB/Swiss-Prot for AIFM3 Gene

  • Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AIFM3 Gene

Genomics for AIFM3 Gene

Regulatory Elements for AIFM3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AIFM3 Gene

Start:
20,965,108 bp from pter
End:
20,981,360 bp from pter
Size:
16,253 bases
Orientation:
Plus strand

Genomic View for AIFM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AIFM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AIFM3 Gene

Proteins for AIFM3 Gene

  • Protein details for AIFM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NN9-AIFM3_HUMAN
    Recommended name:
    Apoptosis-inducing factor 3
    Protein Accession:
    Q96NN9
    Secondary Accessions:
    • B7WP37
    • D3DX37
    • D3DX38
    • Q6ZT44
    • Q8N1V3
    • Q8N5E0

    Protein attributes for AIFM3 Gene

    Size:
    605 amino acids
    Molecular mass:
    66791 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AIFM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AIFM3 Gene

Proteomics data for AIFM3 Gene at MOPED

Post-translational modifications for AIFM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for AIFM3 Gene

Domains for AIFM3 Gene

Suggested Antigen Peptide Sequences for AIFM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96NN9

UniProtKB/Swiss-Prot:

AIFM3_HUMAN :
  • Q96NN9
Domain:
  • The Rieske domain induces apoptosis
  • Contains 1 Rieske domain.
Family:
  • Belongs to the FAD-dependent oxidoreductase family.
genes like me logo Genes that share domains with AIFM3: view

No data available for Gene Families for AIFM3 Gene

Function for AIFM3 Gene

Molecular function for AIFM3 Gene

UniProtKB/Swiss-Prot Function:
Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.

Enzyme Numbers (IUBMB) for AIFM3 Gene

Gene Ontology (GO) - Molecular Function for AIFM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
GO:0051537 2 iron, 2 sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with AIFM3: view

Phenotypes for AIFM3 Gene

GenomeRNAi human phenotypes for AIFM3:
genes like me logo Genes that share phenotypes with AIFM3: view

Animal Model Products

CRISPR Products

miRNA for AIFM3 Gene

miRTarBase miRNAs that target AIFM3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AIFM3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for AIFM3 Gene

Localization for AIFM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AIFM3 Gene

Mitochondrion. Note=Does not translocate to the nucleus upon induction of apoptosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AIFM3 Gene COMPARTMENTS Subcellular localization image for AIFM3 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 4
cytosol 3
plasma membrane 3
extracellular 2

Gene Ontology (GO) - Cellular Components for AIFM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 15764604
GO:0005739 mitochondrion IDA 15764604
GO:0005743 mitochondrial inner membrane IDA 15764604
GO:0005783 endoplasmic reticulum IDA 15764604
genes like me logo Genes that share ontologies with AIFM3: view

Pathways for AIFM3 Gene

SuperPathways for AIFM3 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for AIFM3 Gene

Gene Ontology (GO) - Biological Process for AIFM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045454 cell redox homeostasis IEA --
GO:0055114 oxidation-reduction process IEA --
GO:0097194 execution phase of apoptosis IDA 15764604
genes like me logo Genes that share ontologies with AIFM3: view

No data available for Pathways by source for AIFM3 Gene

Compounds for AIFM3 Gene

(1) HMDB Compounds for AIFM3 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
genes like me logo Genes that share compounds with AIFM3: view

Transcripts for AIFM3 Gene

Unigene Clusters for AIFM3 Gene

Apoptosis-inducing factor, mitochondrion-associated, 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AIFM3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AIFM3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^
SP1: - - - - -
SP2: - - - - - - - - - -
SP3: -
SP4: - - - - - -
SP5:
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - -
SP9:
SP10: - -
SP11: - - - - - - - -
SP12: - - - - - - - -
SP13: - - - -
SP14: -
SP15: - - - - -

ExUns: 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23
SP1: - -
SP2: - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for AIFM3 Gene

GeneLoc Exon Structure for
AIFM3
ECgene alternative splicing isoforms for
AIFM3

Expression for AIFM3 Gene

mRNA expression in normal human tissues for AIFM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AIFM3 Gene

This gene is overexpressed in Brain - Amygdala (4.9), Colon - Transverse (4.8), Brain - Caudate (basal ganglia) (4.4), Brain - Cortex (4.2), and Brain - Putamen (basal ganglia) (4.2).

Protein differential expression in normal tissues for AIFM3 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (39.1), Neutrophil (9.9), and Monocytes (9.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AIFM3 Gene

SOURCE GeneReport for Unigene cluster for AIFM3 Gene Hs.723246

mRNA Expression by UniProt/SwissProt for AIFM3 Gene

Q96NN9-AIFM3_HUMAN
Tissue specificity: Ubiquitous. Expressed in bone marrow, cerebral cortex, liver, ovary, thymus, thyroid gland and tongue (at protein level).
genes like me logo Genes that share expressions with AIFM3: view

Expression partners for AIFM3 Gene

In Situ Assay Products

Orthologs for AIFM3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AIFM3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AIFM3 35
  • 90.13 (n)
  • 94.31 (a)
AIFM3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AIFM3 35
  • 89.65 (n)
  • 95.22 (a)
AIFM3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aifm3 35
  • 87.96 (n)
  • 96.15 (a)
Aifm3 16
Aifm3 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AIFM3 35
  • 99.28 (n)
  • 99.5 (a)
AIFM3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aifm3 35
  • 88.13 (n)
  • 96.03 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia AIFM3 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves AIFM3 35
  • 76.42 (n)
  • 80.94 (a)
AIFM3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AIFM3 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493696 35
  • 69.37 (n)
  • 77.36 (a)
African clawed frog
(Xenopus laevis)
Amphibia nfrl-A 35
zebrafish
(Danio rerio)
Actinopterygii LOC100150876 35
  • 66.27 (n)
  • 67.85 (a)
AIFM3 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003904 35
  • 52.74 (n)
  • 41.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10700 36
  • 36 (a)
OneToMany
CG4199 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F20D6.11 36
  • 33 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons MDAR6 35
  • 39.92 (n)
  • 28.02 (a)
rice
(Oryza sativa)
Liliopsida Os08g0151800 35
  • 40.78 (n)
  • 29.97 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05850 35
  • 52.06 (n)
  • 38.25 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes aif1 35
  • 46.5 (n)
  • 38.66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
Species with no ortholog for AIFM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AIFM3 Gene

ENSEMBL:
Gene Tree for AIFM3 (if available)
TreeFam:
Gene Tree for AIFM3 (if available)

Paralogs for AIFM3 Gene

Paralogs for AIFM3 Gene

genes like me logo Genes that share paralogs with AIFM3: view

Variants for AIFM3 Gene

Sequence variations from dbSNP and Humsavar for AIFM3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs57610 -- 20,975,213(+) ccgcc(C/T)acctc intron-variant
rs178254 -- 20,968,063(+) CTCGG(C/T)AGGCC intron-variant
rs178255 -- 20,968,548(+) CACCA(C/T)CCAAC intron-variant
rs178256 -- 20,968,600(+) GTGCT(A/G)GGGGA intron-variant
rs178257 -- 20,968,782(+) CAACC(C/T)GCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AIFM3 Gene

Variant ID Type Subtype PubMed ID
nsv436864 CNV Insertion 17901297
nsv914390 CNV Gain 21882294
nsv523162 CNV Loss 19592680
esv2678175 CNV Deletion 23128226
nsv914418 CNV Gain 21882294
nsv914419 CNV Gain 21882294
nsv834141 CNV Loss 17160897
dgv4872n71 CNV Loss 21882294
nsv914423 CNV Gain 21882294
nsv828960 CNV Loss 20364138
nsv914424 CNV Loss 21882294
nsv914425 CNV Loss 21882294
dgv4873n71 CNV Loss 21882294
nsv191576 CNV Loss 16902084
nsv520145 CNV Loss 19592680
nsv471185 CNV Loss 18288195
nsv834142 CNV Gain 17160897
nsv828961 CNV Gain 20364138

Relevant External Links for AIFM3 Gene

HapMap Linkage Disequilibrium report
AIFM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AIFM3 Gene

Disorders for AIFM3 Gene

Relevant External Links for AIFM3

Genetic Association Database (GAD)
AIFM3
Human Genome Epidemiology (HuGE) Navigator
AIFM3

No disorders were found for AIFM3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for AIFM3 Gene

Publications for AIFM3 Gene

  1. Molecular cloning and characterization of a human AIF-like gene with ability to induce apoptosis. (PMID: 15764604) Xie Q. … Bonanno J.A. (J. Biol. Chem. 2005) 2 3 4 23
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for AIFM3 Gene

Sources for AIFM3 Gene

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