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Aliases & Descriptions for AIFM3
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases AIFL 1 , 2 , 3 EC 1.-.-.- 3 FLJ30473 1 , 2 FLJ45137 2
Descriptions Apoptosis-inducing factor-like protein 3 apoptosis-inducing factor like 2 apoptosis-inducing factor, mitochondrion-associated, 3 2
Search outside databases for aliases for AIFM3 gene
Summaries for AIFM3 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: AIFM3_HUMAN, Q96NN9 Function : Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membranepotential
Genomic Location for AIFM3
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.21 AIFM3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure
GeneLoc location for GC22P019649:
(about GC identifiers )
Start:
19,649,434 bp from pter
End:
19,665,649 bp from pter
Size:
16,216 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000022.9 NT_011520.11 Proteins for AIFM3
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: AIFM3_HUMAN, Q96NN9 (See
protein sequence )Recommended Name: Apoptosis-inducing factor 3 Size : 605 amino acids; 66791 Da
Subcellular location : Mitochondrion. Note=Does not translocate to the nucleus upon induction ofapoptosis
Secondary accessions : Q6ZT44 Q8N1V3 Q8N5E0Alternative splicing : 3 isoforms : Q96NN9-1 Q96NN9-2 Q96NN9-3
REFSEQ proteins (3 alternative transcripts):
NP_001018070.1 NP_001139760.1 NP_653305.1 ENSEMBL proteins: ENSP00000385800 ENSP00000382120 ENSP00000382116 ENSP00000335369 ENSP00000327671 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: AIFM3 5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7
):
About this table Antibodies for AIFM3: Assays for AIFM3:
Protein
Domains/ Families for AIFM3(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q96NN9 ProtoNet protein and cluster: Q96NN9
3 Blocks protein families : IPB001327 Pyridine nucleotide-disulphide oxidoreductase IPB005806 Rieske [2Fe-2S] domain IPB013027 FAD-dependent pyridine nucleotide reductase signature UniProtKB/Swiss-Prot: AIFM3_HUMAN, Q96NN9 Domain : The Rieske domain induces apoptosisSimilarity : Belongs to the FAD-dependent oxidoreductase familySimilarity : Contains 1 Rieske domain
Gene Function for AIFM3
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_144704 Applied Biosystems Silencer ® siRNAs for AIFM3 Sigma-Aldrich siRNA and siRNA Panels for AIFM3 Sigma-Aldrich shRNA Panels and shRNA for AIFM3 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001018060                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001018060                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001018060  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_144704 UniProtKB/Swiss-Prot: AIFM3_HUMAN, Q96NN9 Function : Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membranepotential Enzyme Number (IUBMB): EC 1.-.-.-
5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7
):
About this table
Pathways & Interactions for AIFM3
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for AIFM3 (Your Favorite Gene powered by Ingenuity) --5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7
):
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Drugs & Compounds for AIFM3 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for AIFM3
Transcripts for AIFM3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_144704 Sigma-Aldrich siRNA and siRNA Panels for AIFM3 Sigma-Aldrich shRNA Panels and shRNA for AIFM3 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001018060 NM_144704
REFSEQ mRNAs for AIFM3 gene (3 alternative transcripts): NM_001018060.2 NM_001146288.1 NM_144704.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001018060 NM_144704
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001018060                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001018060                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001018060  
Additional cDNA sequence: AK055035.1 AK094844.1 AK126917.1 AK295581.1 AK316042.1 AY927574.1 AY927594.1 BC032485.1 CR456342.1 CR617219.1 CR626811.1
15 DOTS entries : DT.100779185 DT.40213016 DT.100648655 DT.95270268 DT.423376 DT.120667986 DT.100809547 DT.120668195 DT.95270269 DT.100662270 DT.120668455 DT.120668185 DT.120668326 DT.97816117 DT.99949405
24/206 AceView cDNA sequences (see all 206
):CR626811 NM_006767 AL119038 BC026214 CR600642 AI453247 AI932666 BM773212 CA489669 CR601558 BE673452 BI759539 BQ019651 CA396648 CB155418 BM562885 BM722768 BF196818 BM705145 BM772801 BM697448 BQ182728 CR456342 BU192087
highest scoring ESTs for AIFM3 :AA468769 AA488309 AI343497 AK055035 AK094844 AV723503 BC032485 BI838029 BU101948 BX428309
Unigene Cluster for AIFM3: Apoptosis-inducing factor, mitochondrion-associated, 3 Hs.163543 [show with all ESTs ] Unigene Representative Sequence: AK126917 GeneLoc Exon Structure 5/15 Alternative Splicing Database (ASD) splice patterns (SP) for AIFM3 (see all 15
) ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ SP1 :                     -   -   -   -   -                         SP2 :     -   -   -   -     -       -   -   -   -   -                         SP3 :                                           -           SP4 :               -       -   -   -   -   -                         SP5 :                                                    
ExUns: 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 SP1 :       -               -     SP2 :       -               -     SP3 :       -                   SP4 :                         SP5 :                        
About this scheme ECgene alternative splicing isoforms for AIFM3 5 Ensembl transcripts including schematic representations : ENST00000405089
ENST00000399167
ENST00000399163
ENST00000335375
ENST00000333607
Expression for AIFM3
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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AIFM3 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for AIFM3 1 / 2 / 3
3 probe-sets matching AIFM3 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TTAGACATTASOURCE GeneReport for Unigene cluster: Hs.163543 UniProtKB/Swiss-Prot: AIFM3_HUMAN, Q96NN9 Tissue specificity : Ubiquitous. Expressed in bone marrow, cerebral cortex, liver, ovary, thymus,thyroid gland and tongue (at protein level)
Orthologs for AIFM3
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for AIFM3 gene from 5/14 species (see all 14
)
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
dog (Canis familiaris)
AIFM31
--
apoptosis-inducing factor, mitochondrion-associated, more
89.67(n) 95.87(a)
486440 XM_543566.2 XP_543566.2
cow (Bos taurus)
AIFM31
--
apoptosis-inducing factor, mitochondrion-associated, more
90.16(n) 95.67(a)
526295 NM_001046281.1 NP_001039746.1
rat (Rattus norvegicus)
Aifm31
--
apoptosis-inducing factor, mitochondrion-associated more
88.11(n) 96.15(a)
303786 XM_001058959.1 XP_001058959.1
mouse (Mus musculus)
Aifm31 , 5
165
apoptosis-inducing factor, mitochondrion-associated more 1, 5
87.96(n) 1 96.15(a) 1
72168 1 NM_175178.3 1 NP_780387.2 1 AI840249 5 AK012958 5 (see all 10 )
chicken (Gallus gallus)
AIFM31
--
apoptosis-inducing factor, mitochondrion-associated, more
75.72(n) 79.67(a)
416999 XM_415290.2 XP_415290.2
About this table Species with no ortholog for AIFM3 ENSEMBL Gene Tree for AIFM3 Paralogs for AIFM3 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for AIFM3 gene AIFM1 2
SNPs/Variants for AIFM3 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for AIFM3 (up to first 250kb)
Disorders & Mutations for AIFM3
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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Medical News for AIFM3 (Possibly Related Articles in
Doctor's Guide )
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Publications for AIFM3 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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9 PubMed articles for AIFM3 gene : Molecular cloning and characterization of a human AIF-like gene with ability to induce apoptosis. (PubMed id 15764604) 1, 2, 3, 4 Xie Q.... Bonanno J.A. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802) 3, 4 Collins J.E.... Dunham I. (2004) H. pylori-induced apoptosis in human gastric cancer cells mediated via the release of apoptosis-inducing factor from mitochondria. (PubMed id 19166416) 3 Ashktorab H....Smoot D.T. (2008) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 3 Kimura K.... Sugano S. (2006) AIF suppresses chemical stress-induced apoptosis and maintains the transformed state of tumor cells. (PubMed id 16001080) 3 Urbano A....Porter A. (2005) Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. (PubMed id 15790807) 3 Cheng J....Gingeras T.R. (2005) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002)
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Genome Databases showing AIFM3
(According to
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing AIFM3
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Specialized Databases showing AIFM3 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for AIFM3 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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