Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



AIFM2 Gene

protein-coding   GIFtS: 54
GCID: GC10M071857

Apoptosis-Inducing Factor, Mitochondrion-Associated, 2

(Previous name: apoptosis-inducing factor (AIF)-like mitochondrion-associated...)
(Previous symbol: AMID)
  See AIFM2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Apoptosis-Inducing Factor, Mitochondrion-Associated, 21 2     Apoptosis-Inducing Factor (AIF)-Homologous Mitochondrion-Associated
Inducer Of Death2
AMID1 2 3     Apoptosis-Inducing Factor 22
Apoptosis-Inducing Factor (AIF)-Like Mitochondrion-Associated Inducer Of
Death1 2
     EC 1.-.-.-3
PRG32 3     Apoptosis-Inducing Factor Homologous Mitochondrion-Associated Inducer Of
Death3
P53-Responsive Gene 3 Protein2 3     Apoptosis-Inducing Factor-Like Mitochondrion-Associated Inducer Of Death3

External Ids:    HGNC: 214111   Entrez Gene: 848832   Ensembl: ENSG000000422867   OMIM: 6051595   UniProtKB: Q9BRQ83   

Export aliases for AIFM2 gene to outside databases

Previous GC identifers: GC10M071528 GC10M065864


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for AIFM2 Gene:
This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to
apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by
tumor suppressor protein p53 in colon cancer cells. (provided by RefSeq, Nov 2010)

GeneCards Summary for AIFM2 Gene:
AIFM2 (apoptosis-inducing factor, mitochondrion-associated, 2) is a protein-coding gene. Diseases associated with AIFM2 include colon cancer. GO annotations related to this gene include electron-transferring-flavoprotein dehydrogenase activity and flavin adenine dinucleotide binding.

UniProtKB/Swiss-Prot: AIFM2_HUMAN, Q9BRQ8
Function: Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable
oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in
a sequence-independent manner. May contribute to genotoxin-induced growth arrest

Gene Wiki entry for AIFM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the AIFM2 gene promoter:
         AhR   Pax-5   AP-1   ATF-2   Arnt   GATA-1   FOXL1   CREB   FOXO4   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AIFM2 promoter sequence
   Search Chromatin IP Primers for AIFM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AIFM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.2

AIFM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AIFM2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M071857:  view genomic region     (about GC identifiers)

Start:
71,857,979 bp from pter      End:
71,892,690 bp from pter
Size:
34,712 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AIFM2_HUMAN, Q9BRQ8 (See protein sequence)
Recommended Name: Apoptosis-inducing factor 2  
Size: 373 amino acids; 40527 Da
Cofactor: Binds 6-hydroxy-FAD non-covalently
Secondary accessions: B3KXI0 Q63Z39
Alternative splicing: 2 isoforms:  Q9BRQ8-1   Q9BRQ8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AIFM2: NX_Q9BRQ8

Explore proteomics data for AIFM2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys193
  • Modification sites at PhosphoSitePlus

  • See AIFM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_116186.1  NP_001185625.1  

    ENSEMBL proteins: 
     ENSP00000362345   ENSP00000312370  

    AIFM2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for AIFM2
    OriGene Protein Over-expression Lysate for AIFM2
    OriGene MassSpec for AIFM2
    OriGene Custom Protein Services for AIFM2
    GenScript Custom Purified and Recombinant Proteins Services for AIFM2
    Novus Biologicals AIFM2 Proteins
    Novus Biologicals AIFM2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for AIFM2 

     
    antibodies-online proteins for AIFM2 (7 products) 

     
    antibodies-online peptides for AIFM2

    AIFM2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of AIFM2
    Browse R&D Systems for Antibodies
    OriGene Antibodies for AIFM2
    OriGene Custom Antibody Services for AIFM2
    Novus Biologicals AIFM2 Antibodies
    Search for Antibodies for AIFM2 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for AIFM2
    LSBio Antibodies in human, mouse, rat for AIFM2
    antibodies-online antibodies for AIFM2 (53 products) 

    AIFM2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AIFM2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AIFM2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for AIFM2 
    antibodies-online kits for AIFM2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR013027 FAD_pyr_nucl-diS_OxRdtase
     IPR000103 Pyridine_nuc-diS_OxRdtase_2
     IPR001327 Pyr_OxRdtase_NAD-bd_dom
     IPR023753 Pyr_nucl-diS_OxRdtase_FAD/NAD

    Graphical View of Domain Structure for InterPro Entry Q9BRQ8

    ProtoNet protein and cluster: Q9BRQ8

    2 Blocks protein domains:
    IPB000103 Pyridine nucleotide-disulphide oxidoreductase
    IPB001327 Pyridine nucleotide-disulphide oxidoreductase


    UniProtKB/Swiss-Prot: AIFM2_HUMAN, Q9BRQ8
    Similarity: Belongs to the FAD-dependent oxidoreductase family


    Find genes that share domains with AIFM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AIFM2_HUMAN, Q9BRQ8
    Function: Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable
    oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in
    a sequence-independent manner. May contribute to genotoxin-induced growth arrest
    Induction: Expression detected at 4 hours after induction by p53/TP53. Down-regulated in a wide range of human
    tumors

         Enzyme Number (IUBMB): EC 1.-.-.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA15958387
    GO:0004174electron-transferring-flavoprotein dehydrogenase activity IDA15958387
    GO:0008137NADH dehydrogenase (ubiquinone) activity IBA--
    GO:0016491oxidoreductase activity ----
    GO:0050660flavin adenine dinucleotide binding IDA15958387
         
    Find genes that share ontologies with AIFM2           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Aifm2):
     cellular  reproductive system  tumorigenesis 

    Find genes that share phenotypes with AIFM2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Aifm2tm1Hbsh for AIFM2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AIFM2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AIFM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AIFM2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AIFM2

    miRNA
    Products:
        
    miRTarBase miRNAs that target AIFM2:
    hsa-mir-140-3p (MIRT038645), hsa-mir-15b-5p (MIRT046525), hsa-mir-16-5p (MIRT031880), hsa-mir-1 (MIRT023966)

    Block miRNA regulation of human, mouse, rat AIFM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AIFM2 (see all 14):
    hsa-miR-485-5p hsa-miR-600 hsa-miR-137 hsa-miR-92a hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-1912
    SwitchGear 3'UTR luciferase reporter plasmidAIFM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AIFM2
    Predesigned siRNA for gene silencing in human, mouse, rat AIFM2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AIFM2

    Clone
    Products:
         
    OriGene clones in human, mouse for AIFM2 (see all 7)
    OriGene ORF clones in mouse, rat for AIFM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): AIFM2 (NM_001198696)
    Sino Biological Human cDNA Clone for AIFM2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AIFM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIFM2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AIFM2
    Browse ESI BIO Cell Lines and PureStem Progenitors for AIFM2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIFM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    AIFM2_HUMAN, Q9BRQ8: Cytoplasm. Mitochondrion outer membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion5
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005737cytoplasm IDA12135761
    GO:0005739mitochondrion IDA11980907
    GO:0005741mitochondrial outer membrane IDA11980907
    GO:0005811lipid particle IDA14741744

    Find genes that share ontologies with AIFM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for AIFM2 About    
    See pathways by source

    SuperPathContained pathways About
    1Direct p53 effectors
    Direct p53 effectors


    1 BioSystems Pathway for AIFM2
        Direct p53 effectors



        Pathway & Disease-focused RT2 Profiler PCR Arrays including AIFM2: 
              Mitochondria in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for AIFM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for AIFM2 (Q9BRQ83 ENSP000003123704) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    TP53ENSP000002693054STRING: ENSP00000269305
    NDUFAB1ENSP000000075164STRING: ENSP00000007516
    ENDOGENSP000003617254STRING: ENSP00000361725
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008637apoptotic mitochondrial changes IDA11980907
    GO:0030261chromosome condensation ----
    GO:0043065positive regulation of apoptotic process IDA11980907
    GO:0055114oxidation-reduction process ----
    GO:0097194execution phase of apoptosis ----

    Find genes that share ontologies with AIFM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AIFM2

    1 HMDB Compound for AIFM2    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for AIFM2 gene (2 alternative transcripts): 
    NM_032797.5  NM_001198696.1  

    Unigene Cluster for AIFM2:

    Apoptosis-inducing factor, mitochondrion-associated, 2
    Hs.650680  [show with all ESTs]
    Unigene Representative Sequence: NM_001198696
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373248(uc010qjg.2) ENST00000307864(uc021psi.1 uc001jqp.2)
    ENST00000482166
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AIFM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AIFM2 (see all 14):
    hsa-miR-485-5p hsa-miR-600 hsa-miR-137 hsa-miR-92a hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-1912
    SwitchGear 3'UTR luciferase reporter plasmidAIFM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AIFM2
    Predesigned siRNA for gene silencing in human, mouse, rat AIFM2
    Clone
    Products:
         
    OriGene clones in human, mouse for AIFM2 (see all 7)
    OriGene ORF clones in mouse, rat for AIFM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): AIFM2 (NM_001198696)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AIFM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIFM2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AIFM2
    OriGene qSTAR qPCR primer pairs in human, mouse for AIFM2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AIFM2
      QuantiTect SYBR Green Assays in human, mouse, rat AIFM2
      QuantiFast Probe-based Assays in human, mouse, rat AIFM2

    Additional mRNA sequence: 

    AF506757.1 AK027403.1 BC006121.1 BC023601.2 

    14 DOTS entries:

    DT.454747  DT.101982661  DT.100783285  DT.100792928  DT.100665228  DT.102829849  DT.92426002  DT.92426003 
    DT.97862695  DT.100783287  DT.101957929  DT.121261095  DT.121261116  DT.97842335 

    Selected AceView cDNA sequences (see all 143):

    NM_032797 AI922797 BF198007 BU732124 AW239408 CF126913 BQ635940 CR622972 
    CB215085 CD514797 AK127353 BC006121 BU538375 BX283086 CD634367 BM665110 
    AW296831 BC023601 AA320893 BP352946 BU158922 AW016581 AV650782 AI056644 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    AIFM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACCCGCCT
    AIFM2 Expression
    About this image

    AIFM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AIFM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.650680

    UniProtKB/Swiss-Prot: AIFM2_HUMAN, Q9BRQ8
    Tissue specificity: Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively.
    Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta,
    lung, kidney, and pancreas. Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb
    transcript seems to be the major transcript in EB1 colon cancer cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AIFM2: 
              Mitochondria in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AIFM2
    OriGene qSTAR qPCR primer pairs in human, mouse for AIFM2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AIFM2
    QuantiTect SYBR Green Assays in human, mouse, rat AIFM2
    QuantiFast Probe-based Assays in human, mouse, rat AIFM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIFM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AIFM2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aifm21 , 5 apoptosis-inducing factor, mitochondrion-associated more1, 5 86.68(n)1
    90.35(a)1
      10 (32.27 cM)5
    713611  NM_001039194.31  NP_001034283.11 
     617152635 
    chicken
    (Gallus gallus)
    Aves AIFM21 apoptosis-inducing factor, mitochondrion-associated, more 69.27(n)
    69.89(a)
      423720  XM_421597.4  XP_421597.1 
    lizard
    (Anolis carolinensis)
    Reptilia AIFM26
    apoptosis-inducing factor, mitochondrion-associate...
    69(a)
    1 ↔ 1
    3(48791144-48804765)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ057663.12   -- 69.86(n)    BJ057663.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5575071 apoptosis-inducing factor, mitochondrion-associated more 58.42(n)
    56.45(a)
      557507  NM_001200010.1  NP_001186939.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G441901 AT3G44190 45.1(n)
    34.06(a)
      823541  NM_114287.2  NP_190005.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g01503001 Os02g0150300 44.26(n)
    34.1(a)
      4328310  NM_001052436.1  NP_001045901.1 


    ENSEMBL Gene Tree for AIFM2 (if available)
    TreeFam Gene Tree for AIFM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for AIFM2 (see all 505)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1160144291,2
    F--65887177(+) AGAAAC/TGGGGT 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs412779701,2
    --71872544(+) ATCTCG/TCCCAA 2 -- ut310--------
    rs412779721,2
    C,F--71872558(+) GAGGAA/CTCATT 2 -- ut311Minor allele frequency- C:0.03NA 120
    rs108234841,2
    C,F,A,H--71872572(+) ACACTG/TTAACA 2 -- ut31 ese325Minor allele frequency- T:0.29NA NS EA WA 2902
    rs412779741,2
    C,F--71872718(+) TCACTT/CACAAA 2 -- ut312Minor allele frequency- C:0.09WA NA 238
    rs1849739521,2
    --71872843(+) AAACAC/TCTCCA 2 -- ut310--------
    rs78931371,2
    C,F,A,H--71872947(+) AGCTCT/ATTCTT 2 -- ut31 trp38Minor allele frequency- A:0.28NS EA WA NA 770
    rs1414493471,2
    --71873105(+) GTGAAA/GCCCCG 2 -- ut310--------
    rs1508260271,2
    --71873274(+) CGAGAC/TTGTCT 2 -- ut310--------
    rs1887875541,2
    --71873290(+) ATAAAC/TAAACA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for AIFM2 (71857979 - 71892690 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AIFM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7054CNV Insertion18451855
    esv32737CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AIFM2
    DNA2.0 Custom Variant and Variant Library Synthesis for AIFM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605159    OMIM disorders: --

    1 disease for AIFM2:    
    About MalaCards
    colon cancer


    Find genes that share disorders with AIFM2           About GenesLikeMe

    Genetic Association Database (GAD): AIFM2
    Human Genome Epidemiology (HuGE) Navigator: AIFM2 (3 documents)

    Export disorders for AIFM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for AIFM2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with AIFM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human apoptosis-inducing protein AMID is an oxidoreductase with a modified flavin cofactor and DNA binding activity. (PubMed id 15958387)1, 2, 3, 9 Marshall K.R.... Munro A.W. (J. Biol. Chem. 2005)
    2. AMID, an apoptosis-inducing factor-homologous mitochondrion- associated protein, induces caspase-independent apoptosis. (PubMed id 11980907)1, 2, 3 Wu M.... Shu H.-B. (J. Biol. Chem. 2002)
    3. A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF). (PubMed id 12135761)1, 2, 3 Ohiro Y.... Horikoshi N. (FEBS Lett. 2002)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival. (PubMed id 19270026)1, 4 Quaye L.... Gayther S.A. (Hum. Mol. Genet. 2009)
    6. AMID is a p53-inducible gene downregulated in tumors. (PubMed id 15273740)1, 2 Wu M.... Shu H.-B. (Oncogene 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 84883 HGNC: 21411 AceView: AMID Ensembl:ENSG00000042286 euGenes: HUgn84883
    ECgene: AIFM2 H-InvDB: AIFM2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for AIFM2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AIFM2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AIFM2 gene:
    Search GeneIP for patents involving AIFM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of AIFM2
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for AIFM2   OriGene RNAi products in human, mouse, rat for AIFM2  
     OriGene qPCR primer pairs and template standards for AIFM2   OriGene Protein Over-expression Lysate for AIFM2  
     OriGene MassSpec for AIFM2   OriGene clones in human, mouse for AIFM2  
     OriGene qSTAR qPCR primer pairs in human, mouse for AIFM2   OriGene Purified Protein for AIFM2  
     OriGene ORF clones in mouse, rat for AIFM2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AIFM2   OriGene Custom Protein Services for AIFM2  

     
     
     Block miRNA regulation of human, mouse, rat AIFM2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AIFM2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AIFM2 Predesigned siRNA for gene silencing in human, mouse, rat AIFM2
     QuantiFast Probe-based Assays in human, mouse, rat AIFM2 QuantiTect SYBR Green Assays in human, mouse, rat AIFM2
     PCR Arrays including human, mouse, rat AIFM2 Search Chromatin IP Primers for AIFM2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AIFM2  Search GeneGlobe Interaction Network for AIFM2
     Regulatory tfbs in AIFM2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for AIFM2 GenScript cDNA clones with any tag delivered in your preferred vector for AIFM2
     GenScript Custom Assay Services for AIFM2 GenScript Custom overexpressing Cell Line Services for AIFM2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for AIFM2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for AIFM2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     AIFM2 antibodies
     AIFM2 proteins
     AIFM2 lysates
     Search for Antibodies for AIFM2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for AIFM2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for AIFM2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIFM2
     SwitchGear 3'UTR luciferase reporter plasmids for AIFM2
     SwitchGear Promoter luciferase reporter plasmids for AIFM2
     ThermoFisher Antibody for AIFM2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIFM2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AIFM2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AIFM2
     LSBio Antibodies in human, mouse, rat for AIFM2
     Browse compounds at ApexBio
     Search Addgene for plasmids for AIFM2
      Search eBioscience for proteins for AIFM2
      Search eBioscience for elisas for AIFM2
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for AIFM2 (53 products)
     antibodies-online kits for AIFM2 (6 products)
     antibodies-online peptides for AIFM2
     antibodies-online proteins for AIFM2 (7 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AIFM2 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4