AIFM1 Gene
protein-coding GIFtS : 59
GC0XM129092
apoptosis-inducing factor, mitochondrion-associated, 1 (Previous name: programmed cell death 8 (apoptosis-inducing factor) )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: PDCD8 )
Services
Jump to Section...
Aliases for AIFM1
Databases for AIFM1
Disorders for AIFM1
Domains/Families for AIFM1
Drugs/Compounds for AIFM1
Expression for AIFM1
Function for AIFM1
Location for AIFM1
Medical News for AIFM1
Orthologs for AIFM1
Paralogs for AIFM1
Pathways/Interactions for AIFM1
Proteins for AIFM1
Publications for AIFM1
SNPs for AIFM1
Search Box for AIFM1
Services for AIFM1
Summaries for AIFM1
Technologies for AIFM1
Transcripts for AIFM1
TOP
BOTTOM
Aliases & Descriptions for AIFM1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Aliases AIF 1 , 2 , 3 EC 1.-.-.- 3 MGC111425 2 OTTHUMP00000024007 2 OTTHUMP00000024008 2 OTTHUMP00000024009 2 PDCD8 2 , 3
Descriptions Programmed cell death protein 8 3 apoptosis-inducing factor, mitochondrion-associated, 1 2 programmed cell death 8 2 programmed cell death 8 (apoptosis-inducing factor) 1 , 2 striatal apoptosis-inducing factor 2
Search outside databases for aliases for AIFM1 gene
Summaries for AIFM1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
EntrezGene summary for AIFM1 : This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is foundin the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in thetranslocation of this protein to the nucleus where it effects chromosome condensation andfragmentation. In addition, this gene product induces mitochondria to release the apoptogenicproteins cytochrome c and caspase-9. Several alternative transcripts encoding different isoformshave been identified for this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: AIFM1_HUMAN, O95831 Function : Probable oxidoreductase that acts as a caspase-independent mitochondrial effector ofapoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and largescale DNA fragmentation (in vitro). Binds to DNA in a sequence-independent manner
Gene Wiki entry for AIFM1
Genomic Location for AIFM1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xq25-q26 Ensembl cytogenetic band: Xq25 HGNC cytogenetic band: Xq25-q26 AIFM1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM129092:
(about GC identifiers )
Start:
129,091,018 bp from pter
End:
129,127,489 bp from pter
Size:
36,472 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000023.9 NT_011786.15 Proteins for AIFM1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
UniProtKB/Swiss-Prot: AIFM1_HUMAN, O95831 (See
protein sequence )Recommended Name: Apoptosis-inducing factor 1, mitochondrial precursor Size : 613 amino acids; 66901 Da
Cofactor : FAD
Subunit : Interacts with XIAP
Subcellular location : Mitochondrion intermembrane space. Nucleus. Note=Translocated to the nucleusupon induction of apoptosis
PDB structures from and Proteopedia : 1M6I (3D)
 
Secondary accessions : B2RB08 Q5JUZ7 Q6I9X6 Q9Y3I3 Q9Y3I4Alternative splicing : 3 isoforms : O95831-1 O95831-2 O95831-3
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (5 alternative transcripts):
NP_001124318.1 NP_001124319.1 NP_004199.1 NP_665811.1 NP_665812.1 ENSEMBL proteins: ENSP00000287295 ENSP00000315122 ENSP00000316320 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for AIFM1: Assays for AIFM1:
Protein
Domains/ Families for AIFM1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Graphical View of Domain Structure for InterPro Entry O95831 ProtoNet protein and cluster: O95831
2 Blocks protein families : IPB001327 Pyridine nucleotide-disulphide oxidoreductase IPB013027 FAD-dependent pyridine nucleotide reductase signature UniProtKB/Swiss-Prot: AIFM1_HUMAN, O95831 Similarity : Belongs to the FAD-dependent oxidoreductase family
Gene Function for AIFM1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Inhib. RNA: Invitrogen RNAi Products for gene knock-down (AIFM1 ) Millipore RNAi Products for the Analysis of AIFM1 Gene knock-down Abnova Chimera RNAi Products for Gene knock-down (PDCD8 )
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_001130846 Applied Biosystems Silencer ® siRNAs for AIFM1 Sigma-Aldrich siRNA and siRNA Panels for AIFM1 Sigma-Aldrich shRNA Panels and shRNA for AIFM1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 5 ): NM_001130846                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 5 ): NM_001130846                                  untagged cDNA clones in CMV expression vector (see all 5 ): NM_001130846  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004208 UniProtKB/Swiss-Prot: AIFM1_HUMAN, O95831 Function : Probable oxidoreductase that acts as a caspase-independent mitochondrial effector ofapoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and largescale DNA fragmentation (in vitro). Binds to DNA in a sequence-independent manner Enzyme Number (IUBMB): EC 1.-.-.-
12 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Aifm1) :5 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for AIFM1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
2 Sigma-Aldrich "Your Favorite Gene" Pathways for AIFM1 (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for AIFM1 5/78 Interacting proteins for AIFM1 (ENSP00000287295 3 O95831 1 , 2 ) via UniProtKB, MINT, and/or STRING (see all 78
)About this table 5 Gene Ontology (GO) biological process terms (links to tree view) :
About this table
Drugs & Compounds for AIFM1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Browse Tocris compounds for AIFM1 10/23 Novoseek chemical compound relationships for AIFM1 gene (see all 23
)
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
oxygen
50.00
27
19110029 (2), 12629154 (2), 15486061 (1), 18241839 (1) (see all 21 )
ceramide
38.98
8
15905098 (2), 17471535 (1), 9206994 (1), 10744629 (1) (see all 5 )
atp
35.23
14
12930708 (4), 10744629 (2), 16151635 (1), 18566329 (1) (see all 8 )
dutp
33.67
1
17960113 (1)
nadh
30.09
11
16001080 (3), 16644725 (3), 11278689 (1), 18806756 (1) (see all 6 )
sp 600125
28.30
1
17109472 (1)
3-aminobenzamide
25.47
4
16617673 (3)
5-aminolevulinic acid
17.08
1
17335970 (1)
superoxide
15.31
5
11278689 (1), 15964899 (1), 17711848 (1), 16001080 (1)
nad+
12.54
1
17084037 (1)
About this table
Transcripts for AIFM1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
OriGene , Expression Assays from Applied Biosystems )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Inhib. RNA: Invitrogen RNAi Products for gene knock-down (AIFM1 ) Millipore RNAi Products for the Analysis of AIFM1 Gene knock-down Abnova Chimera RNAi Products for Gene knock-down (PDCD8 )
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_001130846 Sigma-Aldrich siRNA and siRNA Panels for AIFM1 Sigma-Aldrich shRNA Panels and shRNA for AIFM1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001130846 NM_001130847 NM_004208 NM_145812 NM_145813
REFSEQ mRNAs for AIFM1 gene (5 alternative transcripts): NM_001130846.1 NM_001130847.1 NM_004208.2 NM_145812.1 NM_145813.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001130846 NM_001130847 NM_004208 NM_145812 NM_145813
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5 ): NM_001130846                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 5 ): NM_001130846                                  untagged cDNA clones in CMV expression vector (see all 5 ): NM_001130846  
Additional cDNA sequence: AF100928.1 AF131759.1 AK000775.1 AK314446.1 AL049703.1 AL049704.1 AY795556.1 AY795557.1 BC111065.1 BC139738.1 CR457379.1 CR606178.1 CR607158.1 DQ016496.2 DQ016498.1
13 DOTS entries : DT.416157 DT.40282410 DT.95316624 DT.95319362 DT.100893284 DT.100757204 DT.92471187 DT.95316622 DT.100893286 DT.121278913 DT.75149829 DT.91974881 DT.97867069
24/345 AceView cDNA sequences (see all 345
):AA570483 BI835393 BM823862 BX095724 BG119647 AI360370 BM807180 AA907899 CR606178 BQ268360 CF141027 BM835413 BQ012199 AL134627 NM_004208 CA388765 AL049703 BQ581468 AI284946 CR607158 BQ061576 AA907827 AA481316 BQ581783
highest scoring ESTs for AIFM1 :AL049703 AA337888 AF100928 AI791597 AK000775 AL049704 AL545607 AL557331 AW247071 AW401626
Unigene Cluster for AIFM1: Apoptosis-inducing factor, mitochondrion-associated, 1 Hs.424932 [show with all ESTs ] Unigene Representative Sequence: NM_001130847 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for AIFM1 ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 SP1 :         -                                   SP2 :           -                                 SP3 :         -   -   -   -   -   -   -   -   -   -                 SP4 :                                          
About this scheme ECgene alternative splicing isoforms for AIFM1 3 Ensembl transcripts including schematic representations : ENST00000287295
ENST00000319908
ENST00000346424
Expression for AIFM1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
AIFM1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for AIFM1 1 / 2 / 3
3 probe-sets matching AIFM1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AAGACTGAAGSOURCE GeneReport for Unigene cluster: Hs.424932
Orthologs for AIFM1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Orthologs for AIFM1 gene from 5/13 species (see all 13
)
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
dog (Canis familiaris)
AIFM11
--
apoptosis-inducing factor, mitochondrion-associated, more
93.26(n) 94.29(a)
481048 XM_538170.2 XP_538170.2
cow (Bos taurus)
AIFM11
--
apoptosis-inducing factor, mitochondrion-associated, more
88.87(n) 90.3(a)
535714 XM_874789.2 XP_879882.1
rat (Rattus norvegicus)
Aifm11
--
apoptosis-inducing factor, mitochondrion-associated more
90.63(n) 92.65(a)
83533 NM_031356.1 NP_112646.1
mouse (Mus musculus)
Aifm11 , 5
X (17.00 cM) 5
apoptosis-inducing factor, mitochondrion-associated more 1, 5
90.69(n) 1 92.32(a) 1
26926 1 NM_012019.2 1 NP_036149.1 1 AF100927 5 AI426377 5 (see all 18 )
chicken (Gallus gallus)
AIFM11
--
apoptosis-inducing factor, mitochondrion-associated, more
73.43(n) 80.61(a)
428688 NM_001007490.1 NP_001007491.1
About this table Species with no ortholog for AIFM1 ENSEMBL Gene Tree for AIFM1 Paralogs for AIFM1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Paralogs for AIFM1 gene AIFM3 2
SNPs/Variants for AIFM1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
HapMap Linkage Disequilibrium images for AIFM1 (up to first 250kb)
Disorders & Mutations for AIFM1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
OMIM: 300169 10/40 Novoseek disease relationships for AIFM1 gene (see all 40
)
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
cancer
44.23
25
17207087 (6), 15486061 (2), 18085520 (2), 16723191 (2) (see all 11 )
glioblastoma
41.95
1
16158421 (1)
colon cancer
41.14
5
17711848 (1), 19105980 (1), 16001080 (1), 15946692 (1)
cell damage
36.96
3
12930708 (1), 14684364 (1), 12535654 (1)
necrosis
35.45
6
17470554 (2), 16424911 (1), 16219674 (1), 10744629 (1)
tumors
35.41
17
19105980 (2), 16001080 (2), 16267568 (1)
leukemia
34.62
3
17207087 (1), 16109713 (1)
shock
30.38
6
19118093 (1), 10744629 (1), 17222914 (1), 12633846 (1) (see all 5 )
monocytic leukemia
27.48
1
15767555 (1)
neurodegeneration
26.55
2
17150307 (1), 16621561 (1)
About this table
Medical News for AIFM1 (Possibly Related Articles in
Doctor's Guide )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
--
Publications for AIFM1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
10/354 PubMed articles for AIFM1 gene (see all 354
): Molecular characterization of mitochondrial apoptosis-inducing factor. (PubMed id 9989411) 1, 2, 3, 4 Susin S.A.... Kroemer G. (1999) DNA binding is required for the apoptogenic action of apoptosis inducing factor. (PubMed id 12198487) 1, 3, 4 Ye H.... Wu H. (2002) Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. (PubMed id 10913597) 1, 3, 4 Daugas E....Kroemer G. (2000) The DNA sequence of the human X chromosome. (PubMed id 15772651) 3, 4 Ross M.T.... Bentley D.R. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Regulation of AIF expression by p53. (PubMed id 16729031) 1, 3 Stambolsky P....Rotter V. (2006) Identification and characterization of AIFsh2, a mitochondrial apoptosis-inducing factor (AIF) isoform with NADH oxidase activity. (PubMed id 16644725) 1, 3 Delettre C....Susin S.A. (2006) Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. (PubMed id 10744629) 1, 3 Daugas E....Kroemer G. (2000) AIFsh, a novel apoptosis-inducing factor (AIF) pro-apoptotic isoform with potential pathological relevance in human cancer. (PubMed id 16365034) 1, 3 Delettre C.... Susin S.A. (2006) AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis. (PubMed id 14716299) 1, 3 Cande C....Kroemer G. (2004)
Search for AIFM1
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Genome Databases showing AIFM1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Other Databases showing AIFM1
(According to HUGE )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
--
Specialized Databases showing AIFM1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
-- Services for AIFM1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Products for AIFM1:
Antibodies & Assays for AIFM1   (AIF)
Recombinant Proteins (AIF ) Antibodies (AIF )
Search Tocris compounds for AIFM1
Jump to Section...
Aliases for AIFM1
Databases for AIFM1
Disorders for AIFM1
Domains/Families for AIFM1
Drugs/Compounds for AIFM1
Expression for AIFM1
Function for AIFM1
Location for AIFM1
Medical News for AIFM1
Orthologs for AIFM1
Paralogs for AIFM1
Pathways/Interactions for AIFM1
Proteins for AIFM1
Publications for AIFM1
SNPs for AIFM1
Search Box for AIFM1
Services for AIFM1
Summaries for AIFM1
Technologies for AIFM1
Transcripts for AIFM1
TOP
BOTTOM
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009