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AIFM1 Gene

protein-coding GIFtS: 59

GC0XM129092

apoptosis-inducing factor, mitochondrion-associated, 1
(Previous name: programmed cell death 8 (apoptosis-inducing factor) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PDCD8)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AIF ^¹, ², ³
EC 1.-.-.- ^³
MGC111425 ^²
OTTHUMP00000024007 ^²
OTTHUMP00000024008 ^²
OTTHUMP00000024009 ^²
PDCD8 ^², ³

Descriptions
Programmed cell death protein 8 ^³
apoptosis-inducing factor, mitochondrion-associated, 1 ^²
programmed cell death 8 ^²
programmed cell death 8 (apoptosis-inducing factor) ^¹, ²
striatal apoptosis-inducing factor ^²

External Ids
HGNC: 8768¹
Entrez Gene: 9131²
UniProtKB: O95831³
Ensembl: ENSG00000156709⁷

Search outside databases for aliases for AIFM1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AIFM1:

This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found

in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the

translocation of this protein to the nucleus where it effects chromosome condensation and

fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic

proteins cytochrome c and caspase-9. Several alternative transcripts encoding different isoforms

have been identified for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: AIFM1_HUMAN, O95831

Function: Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of

apoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and large

scale DNA fragmentation (in vitro). Binds to DNA in a sequence-independent manner

Gene Wiki entry for AIFM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq25-q26 Ensembl cytogenetic band: Xq25 HGNC cytogenetic band: Xq25-q26

AIFM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM129092: (about GC identifiers)

Start:	129,091,018 bp from pter
End:	129,127,489 bp from pter
Size:	36,472 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_011786.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: AIFM1_HUMAN, O95831 (See protein sequence)

Recommended Name: Apoptosis-inducing factor 1, mitochondrial precursor

Size: 613 amino acids; 66901 Da

Cofactor: FAD

Subunit: Interacts with XIAP

Subcellular location: Mitochondrion intermembrane space. Nucleus. Note=Translocated to the nucleus

upon induction of apoptosis

PDB structures from and Proteopedia :

1M6I (3D)

Secondary accessions: B2RB08 Q5JUZ7 Q6I9X6 Q9Y3I3 Q9Y3I4

Alternative splicing: 3 isoforms: O95831-1 O95831-2 O95831-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (5 alternative transcripts):

NP_001124318.1 NP_001124319.1 NP_004199.1 NP_665811.1 NP_665812.1

ENSEMBL proteins:

ENSP00000287295 ENSP00000315122 ENSP00000316320

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant AIFM1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (AIF)
	Human Recombinant Proteins from Abnova (PDCD8)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	9989411
GO:0005737	cytoplasm	IEA	--
GO:0005739	mitochondrion	TAS	9989411
GO:0005758	mitochondrial intermembrane space	IEA	--

About this table

Antibodies for AIFM1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of AIFM1
	Sigma-Aldrich Antibody Arrays and Antibodies for AIFM1
	R&D Systems Antibodies for AIFM1 (AIF)
	Cell Signaling Technology (CST) Antibodies for AIFM1 (AIF)
	Antibodies from Abcam (AIF), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PDCD8)
	Novus Biologicals Antibodies for AIFM1

Assays for AIFM1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O95831

ProtoNet protein and cluster: O95831

2 Blocks protein families:

IPB001327 Pyridine nucleotide-disulphide oxidoreductase

IPB013027 FAD-dependent pyridine nucleotide reductase signature

UniProtKB/Swiss-Prot: AIFM1_HUMAN, O95831

Similarity: Belongs to the FAD-dependent oxidoreductase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AIFM1)
		Millipore RNAi Products for the Analysis of AIFM1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (PDCD8)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_001130846

Applied Biosystems Silencer® siRNAs for AIFM1

Sigma-Aldrich siRNA and siRNA Panels for AIFM1

Sigma-Aldrich shRNA Panels and shRNA for AIFM1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AIFM1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001130846
Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001130846
untagged cDNA clones in CMV expression vector (see all 5): NM_001130846

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004208

UniProtKB/Swiss-Prot: AIFM1_HUMAN, O95831

Function: Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of

apoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and large

scale DNA fragmentation (in vitro). Binds to DNA in a sequence-independent manner

Enzyme Number (IUBMB): EC 1.-.-.-

12 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Aifm1):

	behavior/neurological	cellular	embryogenesis	growth/size
homeostasis/metabolism	lethality-prenatal/perinatal	life span-post-weaning/aging	muscle	nervous system
skin/coat/nails	vision/eye

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IPI	16713569 17353931
GO:0009055	electron carrier activity	TAS	9989411
GO:0016491	oxidoreductase activity	IEA	--
GO:0050660	FAD binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for AIFM1 (Your Favorite Gene powered by Ingenuity)

Apoptosis Signaling
Mitochondrial Dysfunction

GeneDecks AIFM1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for AIFM1

5/78 Interacting proteins for AIFM1 (ENSP00000287295³ O95831^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 78 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EIF3G	O75821²	STRING (score=.768) MINT-3388512 MINT-3388489 MINT-3388414 MINT-3388563 MINT-3388584 MINT-3388603 MINT-3388464 MINT-3388536 MINT-3388652
ENSG00000204388	P08107²	STRING (score=.893) MINT-13840 MINT-13841
HSPA1A	P08107²	STRING (score=.898) MINT-13840 MINT-13841
BRF2	Q9HAW0¹	EBI-356440, EBI-1055224
C20orf24	Q9BUV8¹	EBI-356440, EBI-1050079

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006309	DNA fragmentation during apoptosis	TAS	9989411
GO:0006915	apoptosis	IEA	--
GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	TAS	9989411
GO:0045454	cell redox homeostasis	IEA	--
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AIFM1
10/23 Novoseek chemical compound relationships for AIFM1 gene (see all 23 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
oxygen	50.00	27	19110029 (2), 12629154 (2), 15486061 (1), 18241839 (1) (see all 21)
ceramide	38.98	8	15905098 (2), 17471535 (1), 9206994 (1), 10744629 (1) (see all 5)
atp	35.23	14	12930708 (4), 10744629 (2), 16151635 (1), 18566329 (1) (see all 8)
dutp	33.67	1	17960113 (1)
nadh	30.09	11	16001080 (3), 16644725 (3), 11278689 (1), 18806756 (1) (see all 6)
sp 600125	28.30	1	17109472 (1)
3-aminobenzamide	25.47	4	16617673 (3)
5-aminolevulinic acid	17.08	1	17335970 (1)
superoxide	15.31	5	11278689 (1), 15964899 (1), 17711848 (1), 16001080 (1)
nad+	12.54	1	17084037 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AIFM1)
		Millipore RNAi Products for the Analysis of AIFM1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (PDCD8)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_001130846

Sigma-Aldrich siRNA and siRNA Panels for AIFM1

Sigma-Aldrich shRNA Panels and shRNA for AIFM1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001130846 NM_001130847 NM_004208 NM_145812 NM_145813

REFSEQ mRNAs for AIFM1 gene (5 alternative transcripts):

NM_001130846.1 NM_001130847.1 NM_004208.2 NM_145812.1 NM_145813.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001130846 NM_001130847 NM_004208 NM_145812 NM_145813

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001130846
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001130846
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_001130846

Additional cDNA sequence:

AF100928.1 AF131759.1 AK000775.1 AK314446.1 AL049703.1 AL049704.1 AY795556.1 AY795557.1

BC111065.1 BC139738.1 CR457379.1 CR606178.1 CR607158.1 DQ016496.2 DQ016498.1

13 DOTS entries:

DT.416157 DT.40282410 DT.95316624 DT.95319362 DT.100893284 DT.100757204 DT.92471187 DT.95316622

DT.100893286 DT.121278913 DT.75149829 DT.91974881 DT.97867069

24/345 AceView cDNA sequences (see all 345 ):

AA570483 BI835393 BM823862 BX095724 BG119647 AI360370 BM807180 AA907899

CR606178 BQ268360 CF141027 BM835413 BQ012199 AL134627 NM_004208 CA388765

AL049703 BQ581468 AI284946 CR607158 BQ061576 AA907827 AA481316 BQ581783

highest scoring ESTs for AIFM1:

AL049703 AA337888 AF100928 AI791597 AK000775 AL049704 AL545607 AL557331 AW247071 AW401626

Unigene Cluster for AIFM1:

Apoptosis-inducing factor, mitochondrion-associated, 1

Hs.424932 [show with all ESTs]

Unigene Representative Sequence: NM_001130847

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for AIFM1

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17
SP1:									-
SP2:											-
SP3:									-		-		-		-		-		-		-		-		-		-
SP4:

About this scheme

ECgene alternative splicing isoforms for AIFM1

3 Ensembl transcripts including schematic representations:

ENST00000287295 ENST00000319908 ENST00000346424

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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AIFM1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AIFM1

¹ / ² / ³

3 probe-sets matching AIFM1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32212_at²^{, 3}	U95-A	3	1.00	0.91	1.00	1.00	AL049703	1.00	1.00	1.00	1
205512_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004208	0.60	1.00	0.82	1
205512_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks AIFM1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAGACTGAAG

SOURCE GeneReport for Unigene cluster: Hs.424932

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AIFM1 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AIFM1¹	--	apoptosis-inducing factor, mitochondrion-associated, more	93.26(n) 94.29(a)	481048 XM_538170.2 XP_538170.2
cow (Bos taurus)	AIFM1¹	--	apoptosis-inducing factor, mitochondrion-associated, more	88.87(n) 90.3(a)	535714 XM_874789.2 XP_879882.1
rat (Rattus norvegicus)	Aifm1¹	--	apoptosis-inducing factor, mitochondrion-associated more	90.63(n) 92.65(a)	83533 NM_031356.1 NP_112646.1
mouse (Mus musculus)	Aifm1^{1, 5}	X (17.00 cM)⁵	apoptosis-inducing factor, mitochondrion-associated more^{1, 5}	90.69(n)¹ 92.32(a)¹	26926¹ NM_012019.2¹ NP_036149.1¹ AF100927⁵ AI426377⁵ (see all 18)
chicken (Gallus gallus)	AIFM1¹	--	apoptosis-inducing factor, mitochondrion-associated, more	73.43(n) 80.61(a)	428688 NM_001007490.1 NP_001007491.1

About this table Species with no ortholog for AIFM1

ENSEMBL Gene Tree for AIFM1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AIFM1 gene

AIFM3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/143 NCBI SNPs in AIFM1 are shown (see all 143 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 66)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs209538^1,2	A,C,F,H	129128783(-)	`TCCTCT/CACTGT`	3	--	ng3¹ trp³		11		EU EA WA NA	724
	rs209539^1,2	C,F,H	129128667(-)	`ACTACA/GCCAGA`	3	--	ng3¹		15		EU EA WA NA	1130
	rs12007545^1,2	C	129098813(+)	`AAGAGC/TTGAAT`	5	Q/Q	syn¹ ut5¹ ut3¹		0	--	--	--	--
	rs2239772^1,2	H	129091689(+)	`TTGTCC/TCTGAG`	5	R/R	syn¹ ut3¹ ese³		4		EU EA WA	418
	rs1139851^1,2	A,C,F,H	129111201(-)	`GAGGAT/CGAAAA`	4	D/D	syn¹ int¹		14		EU EA WA NS NA	771
	rs12014115^1,2	A,C,F,H	129100298(+)	`CCACCG/AATAAT`	4	I/I	syn¹ int¹ ese³		4		EU EA WA	412
	rs209998^1,2	A,C,F,H,O	129097661(+)	`GCTAGG/AGAGAA`	3	--	int¹		21		EA NA EU WA	1588
	rs23962^1,2	A,C,F,H,O	129124095(-)	`GCCTGC/GTCATG`	3	--	int¹		15		EU EA WA NA	972
	rs23963^1,2	A,C,F,H,O	129124075(-)	`TAGAGA/GACCAG`	3	--	int¹		21		EA NA EU WA	1442
	rs586041^1,2	A,C,F,H,O	129096070(-)	`GTGAGA/TGGCAG`	3	--	int¹		7		EU EA WA NA	554

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HapMap Linkage Disequilibrium images for AIFM1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300169

10/40 Novoseek disease relationships for AIFM1 gene (see all 40 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	44.23	25	17207087 (6), 15486061 (2), 18085520 (2), 16723191 (2) (see all 11)
glioblastoma	41.95	1	16158421 (1)
colon cancer	41.14	5	17711848 (1), 19105980 (1), 16001080 (1), 15946692 (1)
cell damage	36.96	3	12930708 (1), 14684364 (1), 12535654 (1)
necrosis	35.45	6	17470554 (2), 16424911 (1), 16219674 (1), 10744629 (1)
tumors	35.41	17	19105980 (2), 16001080 (2), 16267568 (1)
leukemia	34.62	3	17207087 (1), 16109713 (1)
shock	30.38	6	19118093 (1), 10744629 (1), 17222914 (1), 12633846 (1) (see all 5)
monocytic leukemia	27.48	1	15767555 (1)
neurodegeneration	26.55	2	17150307 (1), 16621561 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/354 PubMed articles for AIFM1 gene (see all 354 ):

Molecular characterization of mitochondrial apoptosis-inducing factor. (PubMed id 9989411)^{1, 2, 3, 4} Susin S.A.... Kroemer G. (1999)
DNA binding is required for the apoptogenic action of apoptosis inducing factor. (PubMed id 12198487)^{1, 3, 4} Ye H.... Wu H. (2002)
Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. (PubMed id 10913597)^{1, 3, 4} Daugas E....Kroemer G. (2000)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Regulation of AIF expression by p53. (PubMed id 16729031)^{1, 3} Stambolsky P....Rotter V. (2006)
Identification and characterization of AIFsh2, a mitochondrial apoptosis-inducing factor (AIF) isoform with NADH oxidase activity. (PubMed id 16644725)^{1, 3} Delettre C....Susin S.A. (2006)
Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. (PubMed id 10744629)^{1, 3} Daugas E....Kroemer G. (2000)
AIFsh, a novel apoptosis-inducing factor (AIF) pro-apoptotic isoform with potential pathological relevance in human cancer. (PubMed id 16365034)^{1, 3} Delettre C.... Susin S.A. (2006)
AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis. (PubMed id 14716299)^{1, 3} Cande C....Kroemer G. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9131	HGNC: 8768	AceView: PDCD8	Ensembl:ENSG00000156709	euGenes: HUgn9131
ECgene: AIFM1	H-InvDB: AIFM1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for AIFM1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for AIFM1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AIFM1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AIFM1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

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Antibodies & Assays for AIFM1 (AIF)

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Antibodies for AIFM1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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AIFM1 Gene at Home site.
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AIFM1 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for AIFM1

Summaries
for AIFM1

Genomic Location
for AIFM1

Proteins
for AIFM1

Protein Domains/
Families
for AIFM1

Gene Function
for AIFM1

Pathways & Interactions
for AIFM1

Drugs & Compounds
for AIFM1

Transcripts
for AIFM1

Expression
for AIFM1

Orthologs
for AIFM1

Paralogs
for AIFM1

SNPs/Variants
for AIFM1

Disorders & Mutations
for AIFM1

Medical News
for AIFM1

Publications
for AIFM1

Search for AIFM1

Genome Databases showing AIFM1

Other Databases showing AIFM1

Specialized Databases showing AIFM1

Licensable Technologies
for AIFM1

Services
for AIFM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AIFM1 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor AIFM1

Summariesfor AIFM1

Genomic Locationfor AIFM1

Proteinsfor AIFM1

Protein Domains/Familiesfor AIFM1

Gene Functionfor AIFM1

Pathways & Interactionsfor AIFM1

Drugs & Compoundsfor AIFM1

Transcriptsfor AIFM1

Expression for AIFM1

Orthologsfor AIFM1

Paralogsfor AIFM1

SNPs/Variantsfor AIFM1

Disorders & Mutationsfor AIFM1

Medical Newsfor AIFM1

Publicationsfor AIFM1

Search for AIFM1

Genome Databases showing AIFM1

Other Databases showing AIFM1

Specialized Databases showing AIFM1

Licensable Technologiesfor AIFM1

Servicesfor AIFM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AIFM1

Summaries
for AIFM1

Genomic Location
for AIFM1

Proteins
for AIFM1

Protein Domains/
Families
for AIFM1

Gene Function
for AIFM1

Pathways & Interactions
for AIFM1

Drugs & Compounds
for AIFM1

Transcripts
for AIFM1

Expression
for AIFM1

Orthologs
for AIFM1

Paralogs
for AIFM1

SNPs/Variants
for AIFM1

Disorders & Mutations
for AIFM1

Medical News
for AIFM1

Publications
for AIFM1

Licensable Technologies
for AIFM1

Services
for AIFM1