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Aliases for AIF1L Gene

Aliases for AIF1L Gene

  • Allograft Inflammatory Factor 1 Like 2 3
  • Ionized Calcium-Binding Adapter Molecule 2 3 4
  • Allograft Inflammatory Factor 1-Like 2 5
  • C9orf58 3 4
  • IBA2 3 4
  • Ionized Calcium Binding Adapter Molecule 2 3
  • Chromosome 9 Open Reading Frame 58 2

External Ids for AIF1L Gene

Previous HGNC Symbols for AIF1L Gene

  • C9orf58

Previous GeneCards Identifiers for AIF1L Gene

  • GC09P132962
  • GC09P133971
  • GC09P103462

Summaries for AIF1L Gene

GeneCards Summary for AIF1L Gene

AIF1L (Allograft Inflammatory Factor 1 Like) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and actin filament binding. An important paralog of this gene is AIF1.

UniProtKB/Swiss-Prot for AIF1L Gene

  • Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function.

Gene Wiki entry for AIF1L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AIF1L Gene

Genomics for AIF1L Gene

Regulatory Elements for AIF1L Gene

Enhancers for AIF1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AIF1L on UCSC Golden Path with GeneCards custom track

Promoters for AIF1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AIF1L on UCSC Golden Path with GeneCards custom track

Genomic Location for AIF1L Gene

131,096,476 bp from pter
131,123,152 bp from pter
26,677 bases
Plus strand

Genomic View for AIF1L Gene

Genes around AIF1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AIF1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AIF1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AIF1L Gene

Proteins for AIF1L Gene

  • Protein details for AIF1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Allograft inflammatory factor 1-like
    Protein Accession:
    Secondary Accessions:
    • B2RBC4
    • Q6ZR40
    • Q8NAX7
    • Q8WU47
    • Q9H9G0

    Protein attributes for AIF1L Gene

    150 amino acids
    Molecular mass:
    17068 Da
    Quaternary structure:
    • Homodimer (Potential). Monomer.

    Three dimensional structures from OCA and Proteopedia for AIF1L Gene

    Alternative splice isoforms for AIF1L Gene


neXtProt entry for AIF1L Gene

Proteomics data for AIF1L Gene at MOPED

Post-translational modifications for AIF1L Gene

  • Ubiquitination at Lys 13
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for AIF1L Gene

Domains & Families for AIF1L Gene

Gene Families for AIF1L Gene

Protein Domains for AIF1L Gene

Suggested Antigen Peptide Sequences for AIF1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EF-hand domains.
  • Contains 2 EF-hand domains.
genes like me logo Genes that share domains with AIF1L: view

Function for AIF1L Gene

Molecular function for AIF1L Gene

UniProtKB/Swiss-Prot Function:
Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function.

Gene Ontology (GO) - Molecular Function for AIF1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 actin filament binding IDA 18699778
genes like me logo Genes that share ontologies with AIF1L: view
genes like me logo Genes that share phenotypes with AIF1L: view

Animal Model Products

CRISPR Products

miRNA for AIF1L Gene

miRTarBase miRNAs that target AIF1L

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AIF1L Gene

Localization for AIF1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for AIF1L Gene

Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with F-actin. Partially relocates to membrane ruffles in response to invading bacteria.

Subcellular locations from

Jensen Localization Image for AIF1L Gene COMPARTMENTS Subcellular localization image for AIF1L gene
Compartment Confidence
extracellular 5
cytoskeleton 4
plasma membrane 3
cytosol 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for AIF1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005884 colocalizes_with actin filament IDA 18699778
GO:0032587 ruffle membrane IEA --
GO:0043234 protein complex IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with AIF1L: view

Pathways & Interactions for AIF1L Gene

SuperPathways for AIF1L Gene

No Data Available

Interacting Proteins for AIF1L Gene

Gene Ontology (GO) - Biological Process for AIF1L Gene


No data available for Pathways by source and SIGNOR curated interactions for AIF1L Gene

Drugs & Compounds for AIF1L Gene

No Compound Related Data Available

Transcripts for AIF1L Gene

Unigene Clusters for AIF1L Gene

Allograft inflammatory factor 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AIF1L Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11
SP1: - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - -
SP10: -
SP11: - - - - - - - -
SP12: - - - - - - -

Relevant External Links for AIF1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AIF1L Gene

mRNA expression in normal human tissues for AIF1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AIF1L Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.9) and Kidney - Cortex (x5.0).

Protein differential expression in normal tissues from HIPED for AIF1L Gene

This gene is overexpressed in Milk (23.7) and Adrenal (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AIF1L Gene

SOURCE GeneReport for Unigene cluster for AIF1L Gene Hs.4944

genes like me logo Genes that share expression patterns with AIF1L: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for AIF1L Gene

Orthologs for AIF1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for AIF1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AIF1L 35
  • 92.22 (n)
  • 96.67 (a)
AIF1L 36
  • 98 (a)
(Canis familiaris)
Mammalia AIF1L 35
  • 94.67 (n)
  • 97.33 (a)
AIF1L 36
  • 97 (a)
(Mus musculus)
Mammalia Aif1l 35
  • 92 (n)
  • 96 (a)
Aif1l 16
Aif1l 36
  • 96 (a)
(Pan troglodytes)
Mammalia AIF1L 35
  • 98.48 (n)
  • 97.73 (a)
AIF1L 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Aif1l 35
  • 91.33 (n)
  • 96 (a)
(Monodelphis domestica)
Mammalia AIF1L 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia AIF1L 36
  • 90 (a)
(Gallus gallus)
Aves C9ORF58 35
  • 74.07 (n)
  • 75 (a)
AIF1L 36
  • 78 (a)
(Anolis carolinensis)
Reptilia AIF1L 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia aif1l 35
  • 67.14 (n)
  • 66.43 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10091 35
(Danio rerio)
Actinopterygii aif1l 35
  • 73 (n)
  • 79.58 (a)
sbcb10 35
aif1l 36
  • 76 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1794 35
Species with no ortholog for AIF1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AIF1L Gene

Gene Tree for AIF1L (if available)
Gene Tree for AIF1L (if available)

Paralogs for AIF1L Gene

Paralogs for AIF1L Gene

(5) SIMAP similar genes for AIF1L Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with AIF1L: view

Variants for AIF1L Gene

Sequence variations from dbSNP and Humsavar for AIF1L Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs744303 -- 131,103,033(+) GCAGG(C/T)GGGAG intron-variant
rs744304 -- 131,103,337(+) GAGGA(C/T)TTCAG intron-variant
rs744305 -- 131,103,363(+) CACAG(A/C)ATGGT intron-variant
rs748697 -- 131,103,965(-) TTGCC(C/T)TCCTT intron-variant
rs1043169 -- 131,122,156(+) CAGAG(C/G)CTTTG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for AIF1L Gene

Variant ID Type Subtype PubMed ID
dgv2423e1 CNV Complex 17122850
nsv831737 CNV Loss 17160897
nsv831738 CNV Loss 17160897
nsv893973 CNV Gain 21882294
nsv893974 CNV Loss 21882294
dgv8310n71 CNV Loss 21882294

Variation tolerance for AIF1L Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AIF1L Gene

Disorders for AIF1L Gene

Relevant External Links for AIF1L

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for AIF1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AIF1L Gene

Publications for AIF1L Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Structural and functional characterization of human Iba proteins. (PMID: 18699778) Schulze J.O. … Buessow K. (FEBS J. 2008) 3 23
  3. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  4. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N. … Wilson S.A. (Nucleic Acids Res. 2015) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for AIF1L Gene

Sources for AIF1L Gene