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AIF1L Gene

protein-coding   GIFtS: 51
GCID: GC09P133971

Allograft Inflammatory Factor 1-Like

(Previous name: chromosome 9 open reading frame 58)
(Previous symbol: C9orf58)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Allograft Inflammatory Factor 1-Like1 2
C9orf581 2 3
Ionized Calcium-Binding Adapter Molecule 22 3
IBA22 3
Chromosome 9 Open Reading Frame 581
Ionized Calcium Binding Adapter Molecule 22

External Ids:    HGNC: 289041   Entrez Gene: 835432   Ensembl: ENSG000001268787   UniProtKB: Q9BQI03   

Export aliases for AIF1L gene to outside databases

Previous GC identifers: GC09P132962 GC09P103462


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AIF1L Gene:
AIF1L (allograft inflammatory factor 1-like) is a protein-coding gene. Diseases associated with AIF1L include hepatitis b, and hepatitis. GO annotations related to this gene include actin filament binding and calcium ion binding. An important paralog of this gene is AIF1.

UniProtKB/Swiss-Prot: AIF1L_HUMAN, Q9BQI0
Function: Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for
function

Gene Wiki entry for AIF1L (C9orf58) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the AIF1L gene promoter:
         AhR   USF1   p53   NRSF form 1   USF2   USF-1:USF-2   NRSF form 2   Arnt   Evi-1   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAIF1L promoter sequence
   Search Chromatin IP Primers for AIF1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AIF1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.13-q34.3   Ensembl cytogenetic band:  9q34.12   HGNC cytogenetic band: 9q34.13-q34.3

AIF1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AIF1L gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P133971:  view genomic region     (about GC identifiers)

Start:
133,971,863 bp from pter      End:
133,998,539 bp from pter
Size:
26,677 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AIF1L_HUMAN, Q9BQI0 (See protein sequence)
Recommended Name: Allograft inflammatory factor 1-like  
Size: 150 amino acids; 17068 Da
Subunit: Homodimer (Potential). Monomer
2 PDB 3D structures from and Proteopedia for AIF1L:
2JJZ (3D)        2VTG (3D)    
Secondary accessions: B2RBC4 Q6ZR40 Q8NAX7 Q8WU47 Q9H9G0
Alternative splicing: 4 isoforms:  Q9BQI0-1   Q9BQI0-2   Q9BQI0-3   Q9BQI0-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AIF1L: NX_Q9BQI0

Explore proteomics data for AIF1L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys13
  • Modification sites at PhosphoSitePlus

  • See AIF1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001172024.1  NP_001172025.1  NP_113614.1  

    ENSEMBL proteins: 
     ENSP00000361388   ENSP00000247291   ENSP00000361376   ENSP00000361374   ENSP00000361372  
     ENSP00000361371   ENSP00000361375   ENSP00000361383   ENSP00000361386  

    AIF1L Human Recombinant Protein Products:

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    Novus Biologicals AIF1L Proteins
    Novus Biologicals AIF1L Lysates
    Browse Sino Biological Recombinant Proteins
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    ProSpec Recombinant Protein for AIF1L
    Cloud-Clone Corp. Proteins for AIF1L

    AIF1L Antibody Products:

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    Cloud-Clone Corp. CLIAs for AIF1L


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    2 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom

    Graphical View of Domain Structure for InterPro Entry Q9BQI0

    ProtoNet protein and cluster: Q9BQI0

    UniProtKB/Swiss-Prot: AIF1L_HUMAN, Q9BQI0
    Similarity: Contains 2 EF-hand domains


    AIF1L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AIF1L_HUMAN, Q9BQI0
    Function: Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for
    function

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0051015actin filament binding IDA18699778
         
    AIF1L for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for AIF1L:
     Cell division defect  Decreased number of cells in m  Increased G2M DNA content  Increased number of mitotic ce 

         1 MGI phenotypic allele for Aif1l (no phenotypes)

    AIF1L for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AIF1L
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AIF1L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AIF1L

    miRNA
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    miRTarBase miRNAs that target AIF1L:
    hsa-mir-1229-3p (MIRT036293), hsa-mir-124-3p (MIRT022475)

    Block miRNA regulation of human, mouse, rat AIF1L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AIF1L (see all 43):
    hsa-miR-582-3p hsa-miR-1321 hsa-miR-938 hsa-miR-632 hsa-miR-218 hsa-miR-29b-1* hsa-miR-409-5p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidAIF1L 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for AIF1L
    Predesigned siRNA for gene silencing in human, mouse, rat AIF1L

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    GenScript: all cDNA clones in your preferred vector (see all 3): AIF1L (NM_031426)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AIF1L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIF1L

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIF1L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AIF1L_HUMAN, Q9BQI0: Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein;
    Cytoplasmic side. Note=Colocalizes with F-actin. Partially relocates to membrane ruffles in response to invading
    bacteria
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol2
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005884colocalizes with actin filament IDA18699778
    GO:0005925focal adhesion IDA--
    GO:0015629actin cytoskeleton IDA--
    GO:0032587ruffle membrane IEA--

    AIF1L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AIF1L
    Interactions:

        Search GeneGlobe Interaction Network for AIF1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for AIF1L (Q9BQI02, 3 ENSP000002472914) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RIPK3Q9Y5722, 3MINT-49121 I2D: score=2 
    KCNMA1Q127913I2D: score=1 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    PI4KBENSP000002716574STRING: ENSP00000271657
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AIF1L



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AIF1L gene (4 alternative transcripts): 
    NM_001002260.1  NM_001185095.1  NM_001185096.1  NM_031426.3  

    Unigene Cluster for AIF1L:

    Allograft inflammatory factor 1-like
    Hs.4944  [show with all ESTs]
    Unigene Representative Sequence: NM_001185095
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372314 ENST00000247291 ENST00000372302 ENST00000372300 ENST00000472942
    ENST00000372298 ENST00000478257 ENST00000372297 ENST00000372301 ENST00000372309(uc004cad.2 uc004cae.2 uc004cab.2 uc004cac.2 uc011mce.1)
    ENST00000372312
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat AIF1L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AIF1L (see all 43):
    hsa-miR-582-3p hsa-miR-1321 hsa-miR-938 hsa-miR-632 hsa-miR-218 hsa-miR-29b-1* hsa-miR-409-5p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidAIF1L 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AIF1L
    Predesigned siRNA for gene silencing in human, mouse, rat AIF1L
    Clone
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    OriGene clones in human, mouse for AIF1L (see all 13)
    OriGene ORF clones in mouse, rat for AIF1L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): AIF1L (NM_031426)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AIF1L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AIF1L
    Primer
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    OriGene qPCR primer pairs and template standards for AIF1L
    OriGene qSTAR qPCR primer pairs in human, mouse for AIF1L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AIF1L
      QuantiTect SYBR Green Assays in human, mouse, rat AIF1L
      QuantiFast Probe-based Assays in human, mouse, rat AIF1L

    Additional mRNA sequence: 

    AK022845.1 AK027181.1 AK057789.1 AK091912.1 AK128526.1 AK300473.1 AK314600.1 AL136566.1 
    AL833896.1 AY359067.1 BC009826.2 BC021253.2 NR_033701.1 

    19 DOTS entries:

    DT.447855  DT.99994868  DT.92017556  DT.100027260  DT.99982473  DT.100792729  DT.121188365  DT.91817513 
    DT.95141278  DT.121188297  DT.92015681  DT.100695306  DT.100792728  DT.121188305  DT.121188316  DT.121188320 
    DT.40200881  DT.100724856  DT.100807027 

    Selected AceView cDNA sequences (see all 272):

    AA598989 CD559010 F04100 T12612 AI885408 BP362284 NM_001002260 CB265746 
    BU171702 BP338824 BF589149 CD633153 NM_031426 CR601218 AW169332 T12552 
    BP338146 CD514425 AA875859 Z40943 AA359971 BP361202 BP348584 BP375194 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AIF1L (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11
    SP1:                    -           -     -                 -     -           -     -     -     -                                                               
    SP2:                    -           -     -     -     -     -     -           -     -     -     -                                                               
    SP3:                    -           -     -     -     -     -     -           -     -     -     -                             -     -     -     -     -         
    SP4:                    -           -     -     -     -     -     -           -     -     -     -                             -     -                           
    SP5:                    -           -     -     -     -     -     -           -     -     -     -           -     -                                             


    ECgene alternative splicing isoforms for AIF1L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AIF1L expression in normal human tissues (normalized intensities)      AIF1L embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGTGTGCG
    AIF1L Expression
    About this image


    AIF1L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Human embryonic stem cells (family)
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Gonad
             Primordial germ cell-like cells
     
     Germ Cells (Reproductive System)
             Primordial germ cell-like cells
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
    AIF1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AIF1L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.4944
        Custom PCR Arrays for AIF1L
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    QuantiFast Probe-based Assays in human, mouse, rat AIF1L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIF1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AIF1L gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aif1l1 , 5 allograft inflammatory factor 1-like1, 5 92(n)1
    96(a)1
      2 (21.95 cM)5
    1088971  NM_145144.11  NP_660126.11 
     319502605 
    chicken
    (Gallus gallus)
    Aves C9ORF581 allograft inflammatory factor 1-like 74.07(n)
    75(a)
      417179  XM_415461.4  XP_415461.1 
    lizard
    (Anolis carolinensis)
    Reptilia AIF1L6
    allograft inflammatory factor 1-like
    74(a)
    1 ↔ 1
    AAWZ02036281(17866-24303)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.100912 Xenopus laevis transcribed sequence with weak similarity more 71.88(n)    CD253668.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb102 sbcb10 75.38(n)   321033  BC059529.1 


    ENSEMBL Gene Tree for AIF1L (if available)
    TreeFam Gene Tree for AIF1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AIF1L gene
    AIF12  
    5 SIMAP similar genes for AIF1L using alignment to 6 protein entries:     AIF1L_HUMAN (see all proteins):
    AIF1    EFHD2    FLJ13612    EFHD1    CALM3

    AIF1L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AIF1L (see all 643)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1474413641,2
    --133969960(+) GATGTC/TGAGAA 4 -- us2k10--------
    rs1811088281,2
    --133970130(+) TCCCCA/GACGGG 4 -- us2k10--------
    rs1416301501,2
    C--133970177(+) GTCTGA/GTCATG 4 -- us2k10--------
    rs8180511,2
    C,F,A,H--133970178(-) GCATGA/GTCAGA 4 -- us2k130Minor allele frequency- T:0.02EA NA NS WA CSA 2684
    rs1120503851,2
    C--133970187(+) GCCTGG/CTGCAT 4 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1843071351,2
    --133970199(+) TGCTGA/GTCTAT 4 -- us2k10--------
    rs1505283551,2
    --133970224(+) GGTGGA/GGCCGC 4 -- us2k10--------
    rs21486631,2
    C,F,A,H--133970244(-) CTGCCG/ACATTC 4 -- us2k19Minor allele frequency- A:0.46NS NA CSA WA EA 487
    rs1890594661,2
    --133970245(+) AATGCA/GGCAGC 4 -- us2k10--------
    rs9330941,2
    C,F,A--133970284(-) CTCAGC/TTGCTG 4 -- us2k19Minor allele frequency- T:0.43NA WA CSA EA 369

    HapMap Linkage Disequilibrium report for AIF1L (133971863 - 133998539 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for AIF1L:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv8310n71CNV Loss21882294
    nsv893974CNV Loss21882294
    nsv831737CNV Loss17160897
    nsv831738CNV Loss17160897
    nsv893973CNV Gain21882294
    dgv2423e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for AIF1L:    About MalaCards
    hepatitis b    hepatitis    endotheliitis


    AIF1L for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: AIF1L (1 document)

    Export disorders for AIF1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AIF1L gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with AIF1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Structural and functional characterization of human Iba proteins. (PubMed id 18699778)1, 2, 9 Schulze J.O....Buessow K. (FEBS J. 2008)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83543 HGNC: 28904 AceView: C9orf58 Ensembl:ENSG00000126878 euGenes: HUgn83543
    ECgene: AIF1L H-InvDB: AIF1L

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AIF1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AIF1L gene:
    Search GeneIP for patents involving AIF1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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