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Aliases for AIF1L Gene

Aliases for AIF1L Gene

  • Allograft Inflammatory Factor 1-Like 2 3
  • Ionized Calcium-Binding Adapter Molecule 2 3 4
  • C9orf58 3 4
  • IBA2 3 4
  • Ionized Calcium Binding Adapter Molecule 2 3
  • Chromosome 9 Open Reading Frame 58 2

External Ids for AIF1L Gene

Previous Symbols for AIF1L Gene

  • C9orf58

Summaries for AIF1L Gene

GeneCards Summary for AIF1L Gene

AIF1L (Allograft Inflammatory Factor 1-Like) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and actin filament binding. An important paralog of this gene is AIF1.

UniProtKB/Swiss-Prot for AIF1L Gene

  • Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function.

Gene Wiki entry for AIF1L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AIF1L Gene

Genomics for AIF1L Gene

Genomic Location for AIF1L Gene

Start:
131,096,476 bp from pter
End:
131,123,152 bp from pter
Size:
26,677 bases
Orientation:
Plus strand

Genomic View for AIF1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AIF1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AIF1L Gene

Regulatory Elements for AIF1L Gene

Proteins for AIF1L Gene

  • Protein details for AIF1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQI0-AIF1L_HUMAN
    Recommended name:
    Allograft inflammatory factor 1-like
    Protein Accession:
    Q9BQI0
    Secondary Accessions:
    • B2RBC4
    • Q6ZR40
    • Q8NAX7
    • Q8WU47
    • Q9H9G0

    Protein attributes for AIF1L Gene

    Size:
    150 amino acids
    Molecular mass:
    17068 Da
    Quaternary structure:
    • Homodimer (Potential). Monomer.

    Three dimensional structures from OCA and Proteopedia for AIF1L Gene

    Alternative splice isoforms for AIF1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AIF1L Gene

Proteomics data for AIF1L Gene at MOPED

Post-translational modifications for AIF1L Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys13

No data available for DME Specific Peptides for AIF1L Gene

Domains for AIF1L Gene

Gene Families for AIF1L Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for AIF1L Gene

Suggested Antigen Peptide Sequences for AIF1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQI0

UniProtKB/Swiss-Prot:

AIF1L_HUMAN
Domain:
  • Contains 2 EF-hand domains.:
    • Q9BQI0
genes like me logo Genes that share domains with AIF1L: view

Function for AIF1L Gene

Molecular function for AIF1L Gene

UniProtKB/Swiss-Prot Function: Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function.

Gene Ontology (GO) - Molecular Function for AIF1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0051015 actin filament binding IDA 18699778
genes like me logo Genes that share ontologies with AIF1L: view
genes like me logo Genes that share phenotypes with AIF1L: view

miRNA for AIF1L Gene

miRTarBase miRNAs that target AIF1L

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for AIF1L Gene

Localization for AIF1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for AIF1L Gene

Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with F-actin. Partially relocates to membrane ruffles in response to invading bacteria.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AIF1L Gene COMPARTMENTS Subcellular localization image for AIF1L gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for AIF1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005884 colocalizes_with actin filament IDA 18699778
GO:0005886 plasma membrane --
GO:0005925 focal adhesion IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with AIF1L: view

Pathways for AIF1L Gene

SuperPathways for AIF1L Gene

No Data Available

Interacting Proteins for AIF1L Gene

Gene Ontology (GO) - Biological Process for AIF1L Gene

None

No data available for Pathways by source for AIF1L Gene

Transcripts for AIF1L Gene

Unigene Clusters for AIF1L Gene

Allograft inflammatory factor 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AIF1L Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11
SP1: - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - -
SP10: -
SP11: - - - - - - - -
SP12: - - - - - - -
SP13:

Relevant External Links for AIF1L Gene

GeneLoc Exon Structure for
AIF1L
ECgene alternative splicing isoforms for
AIF1L

Expression for AIF1L Gene

mRNA expression in normal human tissues for AIF1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AIF1L Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (5.9) and Kidney - Cortex (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AIF1L Gene

SOURCE GeneReport for Unigene cluster for AIF1L Gene Hs.4944

genes like me logo Genes that share expressions with AIF1L: view

No data available for mRNA Expression by UniProt/SwissProt for AIF1L Gene

Orthologs for AIF1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for AIF1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AIF1L 35
  • 98.48 (n)
  • 97.73 (a)
AIF1L 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AIF1L 35
  • 92.22 (n)
  • 96.67 (a)
AIF1L 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AIF1L 35
  • 94.67 (n)
  • 97.33 (a)
AIF1L 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aif1l 35
  • 92 (n)
  • 96 (a)
Aif1l 16
Aif1l 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AIF1L 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AIF1L 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aif1l 35
  • 91.33 (n)
  • 96 (a)
chicken
(Gallus gallus)
Aves AIF1L 36
  • 78 (a)
OneToOne
C9ORF58 35
  • 74.07 (n)
  • 75 (a)
lizard
(Anolis carolinensis)
Reptilia AIF1L 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10091 35
tropical clawed frog
(Silurana tropicalis)
Amphibia aif1l 35
  • 67.14 (n)
  • 66.43 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1794 35
zebrafish
(Danio rerio)
Actinopterygii aif1l 35
  • 73 (n)
  • 79.58 (a)
aif1l 36
  • 76 (a)
OneToOne
sbcb10 35
Species with no ortholog for AIF1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AIF1L Gene

ENSEMBL:
Gene Tree for AIF1L (if available)
TreeFam:
Gene Tree for AIF1L (if available)

Paralogs for AIF1L Gene

Paralogs for AIF1L Gene

Selected SIMAP similar genes for AIF1L Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with AIF1L: view

Variants for AIF1L Gene

Sequence variations from dbSNP and Humsavar for AIF1L Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs184786 -- 131,119,254(-) cgaag(C/T)gctgg intron-variant
rs353510 -- 131,121,116(-) CAGTA(A/T)CCTCC utr-variant-3-prime, nc-transcript-variant
rs353511 -- 131,121,073(-) CCCCC(A/C/G)AAACC utr-variant-3-prime, nc-transcript-variant
rs353512 -- 131,120,797(-) CTGGA(A/G)CCATG utr-variant-3-prime, nc-transcript-variant
rs353513 -- 131,120,572(-) TTGAT(A/G)TCAGC utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for AIF1L Gene

Variant ID Type Subtype PubMed ID
dgv2423e1 CNV Complex 17122850
nsv831737 CNV Loss 17160897
nsv831738 CNV Loss 17160897
nsv893973 CNV Gain 21882294
nsv893974 CNV Loss 21882294
dgv8310n71 CNV Loss 21882294

Relevant External Links for AIF1L Gene

HapMap Linkage Disequilibrium report
AIF1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AIF1L Gene

Disorders for AIF1L Gene

Relevant External Links for AIF1L

Human Genome Epidemiology (HuGE) Navigator
AIF1L
genes like me logo Genes that share disorders with AIF1L: view

No data available for UniProtKB/Swiss-Prot for AIF1L Gene

Publications for AIF1L Gene

  1. Structural and functional characterization of human Iba proteins. (PMID: 18699778) Schulze J.O. … Buessow K. (FEBS J. 2008) 3 4 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4

Products for AIF1L Gene

Sources for AIF1L Gene

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