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Aliases for AIF1 Gene

Aliases for AIF1 Gene

  • Allograft Inflammatory Factor 1 2 3
  • Ionized Calcium-Binding Adapter Molecule 1 2 3 4
  • Interferon Gamma Responsive Transcript 2 3
  • Protein G1 3 4
  • AIF-1 3 4
  • IRT1 3 6
  • IBA1 3 4
  • Allograft Inflammatory Factor-1 Splice Variant Hara-1 3
  • IRT-1 3
  • G1 4

External Ids for AIF1 Gene

Previous GeneCards Identifiers for AIF1 Gene

  • GC06P031646
  • GC06P031353
  • GC06P031688
  • GC06P031689
  • GC06P031690
  • GC06P031582
  • GC06P031369

Summaries for AIF1 Gene

Entrez Gene Summary for AIF1 Gene

  • This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for AIF1 Gene

AIF1 (Allograft Inflammatory Factor 1) is a Protein Coding gene. Diseases associated with AIF1 include chronic inflammatory demyelinating polyneuropathy and demyelinating polyneuropathy. Among its related pathways are Spinal Cord Injury. GO annotations related to this gene include calcium ion binding and actin filament binding. An important paralog of this gene is AIF1L.

UniProtKB/Swiss-Prot for AIF1 Gene

  • Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.

Gene Wiki entry for AIF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AIF1 Gene

Genomics for AIF1 Gene

Regulatory Elements for AIF1 Gene

Genomic Location for AIF1 Gene

Start:
31,615,184 bp from pter
End:
31,617,021 bp from pter
Size:
1,838 bases
Orientation:
Plus strand

Genomic View for AIF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AIF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for AIF1 Gene

  • Protein details for AIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55008-AIF1_HUMAN
    Recommended name:
    Allograft inflammatory factor 1
    Protein Accession:
    P55008
    Secondary Accessions:
    • A8K406
    • O43904
    • Q9UIV4
    • Q9UKS9

    Protein attributes for AIF1 Gene

    Size:
    147 amino acids
    Molecular mass:
    16703 Da
    Quaternary structure:
    • Homodimer (Potential). Monomer. Interacts with LCP1.

    Three dimensional structures from OCA and Proteopedia for AIF1 Gene

    Alternative splice isoforms for AIF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AIF1 Gene

Proteomics data for AIF1 Gene at MOPED

Post-translational modifications for AIF1 Gene

Other Protein References for AIF1 Gene

Antibody Products

No data available for DME Specific Peptides for AIF1 Gene

Domains for AIF1 Gene

Gene Families for AIF1 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for AIF1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P55008

UniProtKB/Swiss-Prot:

AIF1_HUMAN :
  • P55008
Domain:
  • Contains 2 EF-hand domains.
genes like me logo Genes that share domains with AIF1: view

Function for AIF1 Gene

Molecular function for AIF1 Gene

UniProtKB/Swiss-Prot Function: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.

Gene Ontology (GO) - Molecular Function for AIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005509 calcium ion binding ISS 17011575
GO:0005515 protein binding --
GO:0051015 actin filament binding IDA 16049345
genes like me logo Genes that share ontologies with AIF1: view
genes like me logo Genes that share phenotypes with AIF1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AIF1 Gene

Localization for AIF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AIF1 Gene

Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AIF1 Gene COMPARTMENTS Subcellular localization image for AIF1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
plasma membrane 5
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle --
GO:0001891 phagocytic cup ISS --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol IDA 22116621
genes like me logo Genes that share ontologies with AIF1: view

Pathways for AIF1 Gene

SuperPathways for AIF1 Gene

Superpath Contained pathways
1 Spinal Cord Injury
genes like me logo Genes that share pathways with AIF1: view

Pathways by source for AIF1 Gene

1 BioSystems pathway for AIF1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for AIF1 Gene

Gene Ontology (GO) - Biological Process for AIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation NAS 17011575
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0006911 phagocytosis, engulfment ISS --
GO:0006954 inflammatory response NAS 7769138
GO:0010629 negative regulation of gene expression IEA --
genes like me logo Genes that share ontologies with AIF1: view

Compounds for AIF1 Gene

(3) Novoseek inferred chemical compound relationships for AIF1 Gene

Compound -log(P) Hits PubMed IDs
bromodeoxyuridine 9.78 2
calcium 0 13
retinoic acid 0 1
genes like me logo Genes that share compounds with AIF1: view

Transcripts for AIF1 Gene

Unigene Clusters for AIF1 Gene

Allograft inflammatory factor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AIF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AIF1 Gene

No ASD Table

Relevant External Links for AIF1 Gene

GeneLoc Exon Structure for
AIF1
ECgene alternative splicing isoforms for
AIF1

Expression for AIF1 Gene

mRNA expression in normal human tissues for AIF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AIF1 Gene

This gene is overexpressed in Whole Blood (15.6) and Spleen (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AIF1 Gene

SOURCE GeneReport for Unigene cluster for AIF1 Gene Hs.76364

mRNA Expression by UniProt/SwissProt for AIF1 Gene

P55008-AIF1_HUMAN
Tissue specificity: Detected in T-lymphocytes and peripheral blood mononuclear cells.
genes like me logo Genes that share expressions with AIF1: view

In Situ Assay Products

Orthologs for AIF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AIF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AIF1 35
  • 99.32 (n)
  • 99.32 (a)
AIF1 36
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AIF1 35
  • 88.44 (n)
  • 88.44 (a)
AIF1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AIF1 35
  • 90.02 (n)
  • 90.48 (a)
AIF1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aif1 35
  • 88.89 (n)
  • 89.12 (a)
Aif1 16
Aif1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Aif1 35
  • 87.3 (n)
  • 89.8 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 71 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
Species with no ortholog for AIF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AIF1 Gene

ENSEMBL:
Gene Tree for AIF1 (if available)
TreeFam:
Gene Tree for AIF1 (if available)

Paralogs for AIF1 Gene

Paralogs for AIF1 Gene

Selected SIMAP similar genes for AIF1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AIF1: view

Variants for AIF1 Gene

Sequence variations from dbSNP and Humsavar for AIF1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2259571 -- 31,616,050(-) TCAGC(A/C)GGGGA intron-variant, utr-variant-5-prime
rs2269475 -- 31,616,154(-) CACCC(A/G)TTTCT intron-variant, reference, missense
rs2736181 -- 31,615,937(-) CTAGG(G/T)TGTAA intron-variant, utr-variant-5-prime, upstream-variant-2KB
rs2736182 - 31,615,535(-) CAGTC(C/T)GAAAG missense, reference, utr-variant-5-prime, upstream-variant-2KB
rs2844475 -- 31,615,378(-) AATGC(C/T)GCTGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for AIF1 Gene

Variant ID Type Subtype PubMed ID
nsv830627 CNV Loss 17160897
nsv884418 CNV Gain 21882294
nsv462871 CNV Loss 19166990

Relevant External Links for AIF1 Gene

HapMap Linkage Disequilibrium report
AIF1
Human Gene Mutation Database (HGMD)
AIF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AIF1 Gene

Disorders for AIF1 Gene

(1) University of Copenhagen DISEASES for AIF1 Gene

(8) Novoseek inferred disease relationships for AIF1 Gene

Disease -log(P) Hits PubMed IDs
sclerosis systemic 53 11
cerebral infarction 26.6 3
inflammation 8.7 5
autoimmune diseases 0 2
ischemia 0 7

Relevant External Links for AIF1

Genetic Association Database (GAD)
AIF1
Human Genome Epidemiology (HuGE) Navigator
AIF1
genes like me logo Genes that share disorders with AIF1: view

No data available for UniProtKB/Swiss-Prot for AIF1 Gene

Publications for AIF1 Gene

  1. cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries. (PMID: 8912632) Autieri M.V. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23
  2. Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts. (PMID: 8629302) Utans U. … Russell M.E. (Transplantation 1996) 3 4 23
  3. A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. (PMID: 10202016) Neville M.J. … Campbell R.D. (J. Immunol. 1999) 3 4 23
  4. TNF, TNF receptor type 1, and allograft inflammatory factor-1 gene polymorphisms in Japanese patients with type 1 diabetes. (PMID: 12559634) Nishimura M. … Nakamura N. (Hum. Immunol. 2003) 3 23 48
  5. AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF. (PMID: 15117732) Chen X. … Autieri M.V. (Arterioscler. Thromb. Vasc. Biol. 2004) 3 4 23

Products for AIF1 Gene

Sources for AIF1 Gene

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