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AIF1 Gene

protein-coding   GIFtS: 60
GCID: GC06P031582

Allograft Inflammatory Factor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Allograft Inflammatory Factor 11 2     IBA12 3
Ionized Calcium-Binding Adapter Molecule 11 2 3     IRT12 5
Interferon Gamma Responsive Transcript1 2     IRT-12
Protein G12 3     Allograft Inflammatory Factor-1 Splice Variant Hara-12
AIF-12 3     G13

External Ids:    HGNC: 3521   Entrez Gene: 1992   Ensembl: ENSG000002044727   OMIM: 6018335   UniProtKB: P550083   

Export aliases for AIF1 gene to outside databases

Previous GC identifers: GC06P031646 GC06P031353 GC06P031688 GC06P031689 GC06P031690 GC06P031369


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AIF1 Gene:
This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative
regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to
vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Sep 2008)

GeneCards Summary for AIF1 Gene:
AIF1 (allograft inflammatory factor 1) is a protein-coding gene. Diseases associated with AIF1 include blue color blindness, and chronic inflammatory demyelinating polyneuropathy. GO annotations related to this gene include actin filament binding and calcium ion binding. An important paralog of this gene is AIF1L.

UniProtKB/Swiss-Prot: AIF1_HUMAN, P55008
Function: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling
activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage
activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes.
Enhances lymphocyte migration. Plays a role in vascular inflammation

Gene Wiki entry for AIF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NT_113891.3  NT_167245.2  NT_167247.2  NT_167248.2  NT_167249.2  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AIF1 gene promoter:
         ATF-2   COUP   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): AIF1 promoter sequence
   Search Chromatin IP Primers for AIF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AIF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

AIF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AIF1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031582:  view genomic region     (about GC identifiers)

Start:
31,582,961 bp from pter      End:
31,584,798 bp from pter
Size:
1,838 bases      Orientation:
plus strand

5 alternative locations:
Chr6+,NT_167248 2,876,635-2,878,439      Chr6+,NT_167245 2,868,569-2,870,373      Chr6+,NT_167247 2,962,688-2,964,492     
Chr6+,NT_167249 2,913,801-2,915,605      Chr6+,NT_113891.2 3,092,612-3,094,416     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AIF1_HUMAN, P55008 (See protein sequence)
Recommended Name: Allograft inflammatory factor 1  
Size: 147 amino acids; 16703 Da
Subunit: Homodimer (Potential). Monomer. Interacts with LCP1
2 PDB 3D structures from and Proteopedia for AIF1:
2D58 (3D)        2G2B (3D)    
Secondary accessions: A8K406 O43904 Q9UIV4 Q9UKS9
Alternative splicing: 3 isoforms:  P55008-1   P55008-2   P55008-3   

Explore the universe of human proteins at neXtProt for AIF1: NX_P55008

Explore proteomics data for AIF1 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine residues1
  • Ubiquitination2 at Lys11, Lys76
  • Modification sites at PhosphoSitePlus

  • See AIF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001614.3  NP_004838.1  NP_116573.1  

    ENSEMBL proteins: 
     ENSP00000365227   ENSP00000338776   ENSP00000365217  

    AIF1 Human Recombinant Protein Products:

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    AIF1 Antibody Products:

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    AIF1 Assay Products:

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    Cloud-Clone Corp. CLIAs for AIF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR028453 Aif1_like

    Graphical View of Domain Structure for InterPro Entry P55008

    ProtoNet protein and cluster: P55008

    UniProtKB/Swiss-Prot: AIF1_HUMAN, P55008
    Similarity: Contains 2 EF-hand domains


    AIF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AIF1_HUMAN, P55008
    Function: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling
    activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage
    activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes.
    Enhances lymphocyte migration. Plays a role in vascular inflammation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005509calcium ion binding ISS17011575
    GO:0005515protein binding ----
    GO:0051015actin filament binding IDA16049345
         
    AIF1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Aif1):
     hematopoietic system  immune system  skeleton 

    AIF1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AIF1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AIF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AIF1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AIF1_HUMAN, P55008: Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein;
    Cytoplasmic side. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    nucleus5
    plasma membrane5
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle ----
    GO:0001891phagocytic cup ISS--
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol IDA--

    AIF1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AIF1 About    
    See pathways by source

    SuperPathContained pathways About
    1Spinal Cord Injury
    Spinal Cord Injury


    1 BioSystems Pathway for AIF1
        Spinal Cord Injury



        Pathway & Disease-focused RT2 Profiler PCR Array including AIF1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AIF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AIF1 (P550083 ENSP000003652274) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTA1P681333, ENSP000003556454I2D: score=2 STRING: ENSP00000355645
    LCP1P137963, ENSP000003157574I2D: score=2 STRING: ENSP00000315757
    ACTA2ENSP000002247844STRING: ENSP00000224784
    ACTC1ENSP000002903784STRING: ENSP00000290378
    ACTG1ENSP000003315144STRING: ENSP00000331514
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001774microglial cell activation NAS17011575
    GO:0006911phagocytosis, engulfment ISS--
    GO:0006954inflammatory response NAS7769138
    GO:0016601Rac protein signal transduction ISS--
    GO:0030041actin filament polymerization IDA16049345

    AIF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AIF1

    3 Novoseek inferred chemical compound relationships for AIF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bromodeoxyuridine 9.78 9 15904976 (1), 16902995 (1)
    calcium 0 21 15922740 (6), 10934045 (3), 11078214 (2), 18190912 (1) (see all 5)
    retinoic acid 0 1 17533487 (1)



    AIF1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AIF1 gene (3 alternative transcripts): 
    NM_001623.3  NM_004847.3  NM_032955.1  

    Unigene Cluster for AIF1:

    Allograft inflammatory factor 1
    Hs.76364  [show with all ESTs]
    Unigene Representative Sequence: NM_004847
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376059(uc003nuy.3) ENST00000497362 ENST00000337917 ENST00000466820(uc010jsy.3)
    ENST00000376049(uc003nva.3)
    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): AIF1 (NM_004847)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AIF1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AIF1
      QuantiTect SYBR Green Assays in human, mouse, rat AIF1
      QuantiFast Probe-based Assays in human, mouse, rat AIF1

    Additional mRNA sequence: 

    AF088038.1 AF299327.1 AF299329.1 AK290771.1 BC009474.1 CR542153.1 D86438.1 EF070981.1 
    EF070982.1 EF070983.1 U19713.1 U49392.1 U95213.1 

    13 DOTS entries:

    DT.95376329  DT.100035178  DT.91767174  DT.100825623  DT.40116288  DT.95077088  DT.97859011  DT.121350653 
    DT.100035273  DT.121350646  DT.91767173  DT.91767178  DT.121350663 

    Selected AceView cDNA sequences (see all 225):

    BF438657 CD521600 AI472171 D86438 CB053925 AV714667 W69953 BM854652 
    AI052165 AW794442 NM_004847 W67117 AA482171 AI139670 AA045718 U19713 
    AA954019 AA348982 AA256092 CR542153 AW001967 NM_001623 AI338162 AA046385 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AIF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCTGAAAC
    AIF1 Expression
    About this image


    AIF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
    AIF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AIF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.76364

    UniProtKB/Swiss-Prot: AIF1_HUMAN, P55008
    Tissue specificity: Detected in T-lymphocytes and peripheral blood mononuclear cells

        Pathway & Disease-focused RT2 Profiler PCR Array including AIF1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AIF1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aif11 , 5 allograft inflammatory factor 11, 5 88.89(n)1
    89.12(a)1
      17 (18.59 cM)5
    116291  NM_019467.21  NP_062340.11 
     351709915 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    71(a)
    63(a)
    1 ↔ many
    1 ↔ many
    2(193923294-193928746)
    AAWZ02037869(41-12737)


    ENSEMBL Gene Tree for AIF1 (if available)
    TreeFam Gene Tree for AIF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AIF1 gene
    AIF1L2  
    8 SIMAP similar genes for AIF1 using alignment to 4 protein entries:     AIF1_HUMAN (see all proteins):
    AIF1L    EFHD2    FLJ13612    MST133    CALM1    CALM2
    CALM3    CETN2

    AIF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AIF1 (see all 115)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1820665101,2
    --31581008(+) TTCCCC/TACTTT 1 -- us2k10--------
    rs1854776331,2
    --31581031(+) AGGCAC/TCTGGC 1 -- us2k10--------
    rs1399679671,2
    C--31581035(+) ACCTGA/GCGCCT 2 -- us2k10--------
    rs2008550711,2
    C--31581138(+) CTGCC-/CCCGGG 2 -- us2k10--------
    rs1419872491,2
    --31581141(+) CTCCCA/GGGTTT 2 -- us2k10--------
    rs1462960641,2
    C--31581416(+) AGACAA/GGAGTT 2 -- us2k10--------
    rs1900235491,2
    --31581488(+) TATCTA/GTTGAG 2 -- us2k10--------
    rs1394887021,2
    C--31581499(+) TGAACA/GTATGA 2 -- us2k10--------
    rs1428811171,2
    --31581545(+) ACATTA/GGGAGT 2 -- us2k10--------
    rs770996541,2
    C--31581565(+) CAGCTC/GTCTCT 2 -- us2k12Minor allele frequency- G:0.04WA 120

    HapMap Linkage Disequilibrium report for AIF1 (31582961 - 31584798 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for AIF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830627CNV Loss17160897
    nsv462871CNV Loss19166990
    nsv884418CNV Gain21882294

    Human Gene Mutation Database (HGMD): AIF1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AIF1
    DNA2.0 Custom Variant and Variant Library Synthesis for AIF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601833    OMIM disorders: --

    Selected diseases for AIF1 (see all 46):    
    About MalaCards
    blue color blindness    chronic inflammatory demyelinating polyneuropathy    demyelinating polyneuropathy    cerebral artery occlusion
    myocardial infarction susceptibility    color blindness    traumatic brain injury    polyneuropathy
    brain injury    brain ischemia    blindness    neuritis
    narcolepsy    hemangioma    cerebritis    ischemia
    hodgkin's lymphoma    non-hodgkin lymphoma    peritonitis    graft versus host disease

    1 disease from the University of Copenhagen DISEASES database for AIF1:
    Neuritis

    AIF1 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for AIF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sclerosis systemic 53 11 17053503 (4), 17522098 (2), 16868985 (2), 18084000 (1) (see all 6)
    cerebral infarction 26.6 3 10900360 (1), 10683518 (1), 11078214 (1)
    inflammation 8.7 7 10900360 (1), 10683518 (1), 17533487 (1), 18787073 (1) (see all 5)
    autoimmune diseases 0 4 17453710 (1), 17312183 (1)
    ischemia 0 11 16841189 (6), 19235887 (1)
    necrosis 0 4 17498268 (1), 12559634 (1), 16157606 (1)
    glioma 0 2 11078219 (2)
    tumors 0 8 11078219 (2), 17010532 (1), 17498268 (1), 12559634 (1) (see all 5)

    Genetic Association Database (GAD): AIF1
    Human Genome Epidemiology (HuGE) Navigator: AIF1 (14 documents)

    Export disorders for AIF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AIF1 gene, integrated from 10 sources (see all 125):
    (articles sorted by number of sources associating them with AIF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries. (PubMed id 8912632)1, 2, 3, 9 Autieri M.V. (Biochem. Biophys. Res. Commun. 1996)
    2. Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies. (PubMed id 16049345)1, 2, 9 Kelemen S.E. and Autieri M.V. (Am. J. Pathol. 2005)
    3. Allograft inflammatory factor-1 and tumor necrosis factor single nucleotide polymorphisms in systemic sclerosis. (PubMed id 17498268)1, 4, 9 Otieno F.G....Artlett C.M. (Tissue Antigens 2007)
    4. AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF. (PubMed id 15117732)1, 2, 9 Chen X.... Autieri M.V. (Arterioscler. Thromb. Vasc. Biol. 2004)
    5. X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding. (PubMed id 17011575)1, 2, 9 Yamada M.... Kamitori S. (J. Mol. Biol. 2006)
    6. Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts. (PubMed id 8629302)1, 2, 9 Utans U.... Russell M.E. (Transplantation 1996)
    7. Structural and functional characterization of human Iba proteins. (PubMed id 18699778)1, 2, 9 Schulze J.O....Buessow K. (FEBS J. 2008)
    8. TNF, TNF receptor type 1, and allograft inflammatory factor-1 gene polymorphisms in Japanese patients with type 1 diabetes. (PubMed id 12559634)1, 4, 9 Nishimura M....Nakamura N. (Hum. Immunol. 2003)
    9. Association of allograft inflammatory factor-1 gene polymorphism with rheumatoid arthritis. (PubMed id 18721278)1, 4, 9 Pawlik A....Drozdzik M. (Tissue Antigens 2008)
    10. An allograft inflammatory factor 1 (AIF1) single nucleotide polymorphism (SNP) is associated with anticentromere antibody positive systemic sclerosis. (PubMed id 17522098)1, 4, 9 Alkassab F....Mayes M.D. (Rheumatology (Oxford) 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 199 HGNC: 352 AceView: AIF1 Ensembl:ENSG00000204472 euGenes: HUgn199
    ECgene: AIF1 H-InvDB: AIF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AIF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AIF1 gene:
    Search GeneIP for patents involving AIF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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