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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AIF1 Gene

protein-coding   GIFtS: 55
GCID: GC06P031582

allograft inflammatory factor 1
 Explore 46 diseases affiliated with
AIF1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AIF1    

Aliases
for AIF1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Allograft Inflammatory Factor 11 2     IRT12 5
AIF-11 2 3     Em:AF129756.171
IBA11 2 3     Allograft Inflammatory Factor-1 Splice Variant Hara-12
IRT-11 2     Interferon Gamma Responsive Transcript2
Ionized Calcium-Binding Adapter Molecule 12 3     G13
Protein G12 3     

External Ids:    HGNC: 3521   Entrez Gene: 1992   Ensembl: ENSG000002044727   OMIM: 6018335   UniProtKB: P550083   

Export aliases for AIF1 gene to outside databases

Previous GC identifers: GC06P031646 GC06P031353 GC06P031688 GC06P031689 GC06P031690 GC06P031369


Summaries
for AIF1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AIF1:
This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation
of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma.
Three transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2008)

UniProtKB/Swiss-Prot: AIF1_HUMAN, P55008
Function: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling
activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage
activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances
lymphocyte migration. Plays a role in vascular inflammation

Gene Wiki entry for AIF1


Genomic Views
for AIF1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167245.1  NT_167247.1  NT_167248.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AIF1 gene promoter:
         ATF-2   COUP   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): AIF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AIF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AIF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

AIF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AIF1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031582:  view genomic region     (about GC identifiers)

Start:
 31,582,961 bp from pter      End:
 31,584,798 bp from pter
Size:
 1,838 bases      Orientation:
 plus strand

5 alternative locations:
Chr6+,ALT_REF_LOCI_5 31,574,111-31,575,915      Chr6+,ALT_REF_LOCI_6 31,573,205-31,610,623      Chr6+,ALT_REF_LOCI_3 31,565,139-31,578,014     
Chr6+,ALT_REF_LOCI_2 31,570,375-31,611,400      Chr6+,ALT_REF_LOCI_7 31,503,266-31,505,070     

Proteins
for AIF1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AIF1_HUMAN, P55008 (See protein sequence)
Recommended Name: Allograft inflammatory factor 1  
Size: 147 amino acids; 16703 Da
Subunit: Homodimer (Potential). Monomer. Interacts with LCP1
Subcellular location: Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein;
Cytoplasmic side. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis
2 PDB 3D structures from and Proteopedia for AIF1:
2D58 (3D)        2G2B (3D)    
Secondary accessions: A8K406 O43904 Q9UIV4 Q9UKS9
Alternative splicing: 3 isoforms:  P55008-1   P55008-2   P55008-3   

Explore the universe of human proteins at neXtProt for AIF1: NX_P55008

Post-translational modifications:

  • Phosphorylated on serine residues1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55008

    • AIF1 Protein expression data from MOPED and PaxDb:    About this image 
    AIF1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001614.3  NP_004838.1  NP_116573.1  

    ENSEMBL proteins: 
     ENSP00000365227   ENSP00000338776   ENSP00000365217  

    Human Recombinant Protein Products for AIF1: 
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    Novus Biologicals AIF1 Lysate
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    ProSpec Recombinant Protein for AIF1
    Uscn Proteins for AIF1

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle ----
    GO:0001891phagocytic cup ISS--
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol IDA--

    AIF1 for ontologies           About GeneDecksing



    AIF1 Antibody Products: 
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    Uscn ELISAs and CLIAs for AIF1

    Protein Domains /
    Families
    for AIF1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AIF1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd

    Graphical View of Domain Structure for InterPro Entry P55008

    ProtoNet protein and cluster: P55008

    UniProtKB/Swiss-Prot: AIF1_HUMAN, P55008
    Similarity: Contains 2 EF-hand domains


    Function
    for AIF1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AIF1_HUMAN, P55008
    Function: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling
    activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage
    activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances
    lymphocyte migration. Plays a role in vascular inflammation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005509calcium ion binding ISS17011575
    GO:0005515protein binding ----
    GO:0051015actin filament binding IDA16049345
         
    AIF1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for AIF1 

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIF1


    Pathways & Interactions
    for AIF1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AIF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for AIF1 (P550083 ENSP000003652274) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTA1P681333, ENSP000003556454I2D: score=2 STRING: ENSP00000355645
    LCP1P137963, ENSP000003157574I2D: score=2 STRING: ENSP00000315757
    ACTA2ENSP000002247844STRING: ENSP00000224784
    ACTC1ENSP000002903784STRING: ENSP00000290378
    ACTG1ENSP000003315144STRING: ENSP00000331514
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001774microglial cell activation NAS17011575
    GO:0001934positive regulation of protein phosphorylation ----
    GO:0006911phagocytosis, engulfment ISS--
    GO:0006954inflammatory response NAS7769138
    GO:0010629negative regulation of gene expression ----

    AIF1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AIF1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AIF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AIF1
    3 Novoseek chemical compound relationships for AIF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bromodeoxyuridine 9.78 9 15904976 (1), 16902995 (1)
    calcium 0 21 15922740 (6), 10934045 (3), 11078214 (2), 18190912 (1) (see all 5)
    retinoic acid 0 1 17533487 (1)

    Search CenterWatch for drugs/clinical trials and news about AIF1 

    Transcripts
    for AIF1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AIF1 gene (3 alternative transcripts): 
    NM_001623.3  NM_004847.3  NM_032955.1  

    Unigene Cluster for AIF1:

    Allograft inflammatory factor 1
    Hs.76364  [show with all ESTs]
    Unigene Representative Sequence: NM_004847
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376059(uc003nuy.3) ENST00000497362 ENST00000337917 ENST00000466820(uc010jsy.3)
    ENST00000487813 ENST00000376049(uc003nva.3)

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AIF1 (see all 7)
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    Clone
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    Additional cDNA sequence: 

    AF088038.1 AF299327.1 AF299329.1 AK290771.1 BC009474.1 CR542153.1 D86438.1 EF070981.1 
    EF070982.1 EF070983.1 U19713.1 U49392.1 U95213.1 

    13 DOTS entries:

    DT.95376329  DT.100035178  DT.91767174  DT.100825623  DT.40116288  DT.95077088  DT.97859011  DT.121350653 
    DT.100035273  DT.121350646  DT.91767173  DT.91767178  DT.121350663 

    24/225 AceView cDNA sequences (see all 225):

    AA045718 NM_004847 CR542153 AI052165 AF088038 NM_001623 AI057299 W67117 
    F25751 AA348982 CB053925 BM854652 AW794442 AW001967 BM672323 CA307834 
    CD521600 AA046385 AI338162 W69953 AA256092 AV714667 AI139670 BF438657 

    GeneLoc Exon Structure


    Expression
    for AIF1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AIF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCCTGAAAC
    AIF1 Expression
    About this image

    AIF1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    Beating cell clusters (Spontaneous differen...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See AIF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AIF1

    SOURCE GeneReport for Unigene cluster: Hs.76364

    UniProtKB/Swiss-Prot: AIF1_HUMAN, P55008
    Tissue specificity: Detected in T-lymphocytes and peripheral blood mononuclear cells

        SABiosciences Expression via Pathway-Focused PCR Array including AIF1: 
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    In Situ
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    Orthologs
    for AIF1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for AIF1 gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia AIF16
    		 --
    		 71(a)
    		 1 ↔ 1
    		 2(193923294-193928746)


    ENSEMBL Gene Tree for AIF1 (if available)
    TreeFam Gene Tree for AIF1 (if available) 

    Paralogs
    for AIF1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AIF1 gene
    AIF1L2  
    9 SIMAP similar genes for AIF1 using alignment to 4 protein entries:     AIF1_HUMAN (see all proteins):
    AIF1L    EFHD2    FLJ13612    MST133    CALM1    CALM2
    CALM3    CETN2    CETN1

    AIF1 for paralogs           About GeneDecksing



    Genomic Variants
    for AIF1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/90 NCBI SNPs in AIF1 are shown (see all 90)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1820665101,2
    		--31581008(+) TTCCCC/TACTTT 1 -- us2k10--------
    rs1854776331,2
    		--31581031(+) AGGCAC/TCTGGC 1 -- us2k10--------
    rs1399679671,2
    		--31581035(+) ACCTGA/GCGCCT 2 -- us2k10--------
    rs2008550711,2
    		--31581138(+) TGCCT-/CCCGGG 2 -- us2k10--------
    rs1419872491,2
    		--31581141(+) CTCCCA/GGGTTT 2 -- us2k10--------
    rs1462960641,2
    		--31581416(+) AGACAA/GGAGTT 2 -- us2k10--------
    rs1900235491,2
    		--31581488(+) TATCTA/GTTGAG 2 -- us2k10--------
    rs1394887021,2
    		--31581499(+) TGAACA/GTATGA 2 -- us2k10--------
    rs1428811171,2
    		--31581545(+) ACATTA/GGGAGT 2 -- us2k10--------
    rs770996541,2
    		C--31581565(+) CAGCTC/GTCTCT 2 -- us2k12Minor allele frequency- G:0.04WA 120

    HapMap Linkage Disequilibrium report for AIF1 (31582961 - 31584798 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for AIF1: --
    Human Gene Mutation Database (HGMD): AIF1

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    Disorders / Diseases
    for AIF1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AIF1 for disorders           About GeneDecksing

    OMIM gene information: 601833    OMIM disorders: --

    20/46 diseases for AIF1 (see all 46):    About MalaCards
    chronic inflammatory demyelinating polyneuropathy (cidp)    chronic inflammatory demyelinating polyneuropathy    demyelinating polyneuropathy    blue color blindness
    non-small cell lung carcinoma    myocardial infarction susceptibility    traumatic brain injury    non-hodgkin lymphoma
    cerebral artery occlusion    myocardial infarction    color blindness    brain injury
    polyneuropathy    cerebrovascular accident    systemic lupus erythematosus    cerebral infarction
    lupus erythematosus    hodgkin's lymphoma    brain ischemia    cystic fibrosis

    1 disease from the University of Copenhagen DISEASES database for AIF1:
    Neuritis

    8 Novoseek disease relationships for AIF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sclerosis systemic 53 11 17053503 (4), 17522098 (2), 16868985 (2), 18084000 (1) (see all 6)
    cerebral infarction 26.6 3 10900360 (1), 10683518 (1), 11078214 (1)
    inflammation 8.7 7 10900360 (1), 10683518 (1), 17533487 (1), 18787073 (1) (see all 5)
    autoimmune diseases 0 4 17453710 (1), 17312183 (1)
    ischemia 0 11 16841189 (6), 19235887 (1)
    necrosis 0 4 17498268 (1), 12559634 (1), 16157606 (1)
    glioma 0 2 11078219 (2)
    tumors 0 8 11078219 (2), 17010532 (1), 17498268 (1), 12559634 (1) (see all 5)

    Genetic Association Database (GAD): AIF1
    Human Genome Epidemiology (HuGE) Navigator: AIF1 (14 documents)

    Export disorders for AIF1 gene to outside databases

    Publications
    for AIF1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AIF1 gene, integrated from 9 sources (see all 118):
    (articles sorted by number of sources associating them with AIF1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries. (PubMed id 8912632)1, 2, 3, 9 Autieri M.V. (1996)
    2. Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies. (PubMed id 16049345)1, 2, 9 Kelemen S.E. and Autieri M.V. (2005)
    3. AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF. (PubMed id 15117732)1, 2, 9 Chen X.... Autieri M.V. (2004)
    4. X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding. (PubMed id 17011575)1, 2, 9 Yamada M....Kamitori S. (2006)
    5. Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts. (PubMed id 8629302)1, 2, 9 Utans U.... Russell M.E. (1996)
    6. Structural and functional characterization of human Iba proteins. (PubMed id 18699778)1, 2, 9 Schulze J.O....Bussow K. (2008)
    7. TNF, TNF receptor type 1, and allograft inflammatory factor-1 gene polymorphisms in Japanese patients with type 1 diabetes. (PubMed id 12559634)1, 4, 9 Nishimura M....Nakamura N. (2003)
    8. A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. (PubMed id 10202016)1, 2, 9 Neville M.J. and Campbell R.D. (1999)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (2003)

    External Searches for AIF1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing AIF1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 199 HGNC: 352 AceView: AIF1 Ensembl:ENSG00000204472 euGenes: HUgn199
    ECgene: AIF1 H-InvDB: AIF1

    Other Databases showing AIF1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AIF1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AIF1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for AIF1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AIF1 gene:
    Search GeneIP for patents involving AIF1

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