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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AIDA Gene

protein-coding   GIFtS: 45
GCID: GC01M222841

axin interactor, dorsalization associated

(Previous name: chromosome 1 open reading frame 80 )
(Previous symbol: C1orf80)
 Explore 2 diseases affiliated with
AIDA via our new
 Human Malady Compendium 
Biological research products
for AIDA
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Axin Interactor, Dorsalization Associated1 2     Chromosome 1 Open Reading Frame 801
C1orf801 2 3     RP11-378J18.72
Axin Interaction Partner And Dorsalization Antagonist2 3     Axin Interactor, Dorsalization-Associated Protein2
FLJ128061     

External Ids:    HGNC: 257611   Entrez Gene: 648532   Ensembl: ENSG000001860637   OMIM: 6123755   UniProtKB: Q96BJ33   

Export aliases for AIDA gene to outside databases

Previous GC identifers: GC01M220907 GC01M193515


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: AIDA_HUMAN, Q96BJ3
Function: Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and
disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway
activated by AXIN/JNK-signaling (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AIDA gene promoter:
         RP58   MAZR   Pax-6   NRSF form 1   MyoD   NRSF form 2   AREB6   POU2F1   POU2F1b   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAIDA promoter sequence
   Search SABiosciences Chromatin IP Primers for AIDA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AIDA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41

AIDA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AIDA gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M222841:  view genomic region     (about GC identifiers)

Start:
222,841,355 bp from pter      End:
222,886,552 bp from pter
Size:
45,198 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AIDA_HUMAN, Q96BJ3 (See protein sequence)
Recommended Name: Axin interactor, dorsalization-associated protein  
Size: 306 amino acids; 35023 Da
Subunit: Interacts with AXIN1 (By similarity)
Secondary accessions: A8K1F0 Q49A81 Q5JRA4 Q658P1 Q9H9E8
Alternative splicing: 3 isoforms:  Q96BJ3-1   Q96BJ3-2   Q96BJ3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AIDA: NX_Q96BJ3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96BJ3

  • AIDA Protein expression data from MOPED and PaxDb:    About this image 
    AIDA Protein Expression
    REFSEQ proteins: NP_073742.2  
    ENSEMBL proteins: 
     ENSP00000339161   ENSP00000347964   ENSP00000442882  

    Human Recombinant Protein Products for AIDA: 
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    Novus Biologicals AIDA Protein
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    Uscn Proteins for AIDA

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0044444cytoplasmic part IEA--

    AIDA for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for AIDA


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    AIDA for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015006 AIDA
     IPR023421 AIDA_N
     IPR025939 Aida_C

    Graphical View of Domain Structure for InterPro Entry Q96BJ3

    ProtoNet protein and cluster: Q96BJ3

    UniProtKB/Swiss-Prot: AIDA_HUMAN, Q96BJ3
    Similarity: Belongs to the AIDA family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AIDA_HUMAN, Q96BJ3
    Function: Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and
    disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway
    activated by AXIN/JNK-signaling (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019904protein domain specific binding IEA--
         
    AIDA for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for AIDA 

    miRNA
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    hsa-miR-345 hsa-miR-448 hsa-miR-187* hsa-miR-631 hsa-miR-137 hsa-miR-657 hsa-miR-513a-5p hsa-miR-27a
    SwitchGear 3'UTR luciferase reporter plasmidAIDA 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AIDA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AIDA

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for AIDA (Q96BJ32, 3 ENSP000003391614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PINX1Q96BK52, 3MINT-8266612 I2D: score=2 
    PLEKHF2Q9H8W43I2D: score=1 
    SOX7ENSP000003019214STRING: ENSP00000301921
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009953dorsal/ventral pattern formation ISS--
    GO:0043496regulation of protein homodimerization activity ISS--
    GO:0043508negative regulation of JUN kinase activity IDA17681137
    GO:0046329negative regulation of JNK cascade ISS--

    AIDA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AIDA
    Search CenterWatch for drugs/clinical trials and news about AIDA 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AIDA gene: 
    NM_022831.2  

    Unigene Clusters for AIDA:

    Axin interactor, dorsalization associated
    Hs.156625  [show with all ESTs], Hs.534965  [show with all ESTs]
    Unigene Representative Sequences: AK289865, BC043142
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340020(uc001hnn.3 uc010pus.2) ENST00000474863(uc001hno.3)
    ENST00000355727 ENST00000495670 ENST00000470437 ENST00000497112 ENST00000541237


    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate AIDA (see all 14):
    hsa-miR-345 hsa-miR-448 hsa-miR-187* hsa-miR-631 hsa-miR-137 hsa-miR-657 hsa-miR-513a-5p hsa-miR-27a
    SwitchGear 3'UTR luciferase reporter plasmidAIDA 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AIDA (see all 4)
    OriGene shRNA RFP: AIDA
    OriGene siRNA: AIDA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AIDA
    Sirion Biotech Custom design and validation of potent shRNA sequences against AIDA 
    Clone
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    Additional cDNA sequence: 

    AF131838.1 AK022868.1 AK301870.1 AL833718.1 BC015535.1 BC043142.1 BC067805.1 BC171848.1 

    24/37 DOTS entries (see all 37):

    DT.91691294  DT.97797499  DT.118949  DT.121340539  DT.121340556  DT.120772688  DT.121340511  DT.121340509 
    DT.95165330  DT.121340560  DT.121340586  DT.100009524  DT.102834232  DT.121340578  DT.121395293  DT.121395257 
    DT.95165352  DT.121340515  DT.121340546  DT.121395345  DT.121395229  DT.121395294  DT.102834231  DT.120772678 

    24/304 AceView cDNA sequences (see all 304):

    BF115194 AA827713 AV705386 BU183400 BC067805 NM_022831 AI811977 AA970479 
    AI284240 BQ434076 AL833718 AI751447 BU630828 CK430609 CB122472 AA334894 
    AA926781 BG231620 AU131144 AU131086 AU132187 BM803633 AW936167 AI339046 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AIDA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAATTTTTCT
    AIDA Expression
    About this image

    AIDA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See AIDA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AIDA

    SOURCE GeneReport for Unigene clusters: Hs.156625 Hs.534965

    UniProtKB/Swiss-Prot: AIDA_HUMAN, Q96BJ3
    Tissue specificity: Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AIDA gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aida1 , 5 axin interactor, dorsalization associated1, 5 93.88(n)1
    98.03(a)1
      15
    1089091  NM_181732.41  NP_859421.11 
     1832970605 
    chicken
    (Gallus gallus)
    Aves AIDA1 axin interactor, dorsalization associated 87.15(n)
    95.1(a)
      421335  XM_419398.3  XP_419398.2 
    lizard
    (Anolis carolinensis)
    Reptilia AIDA6
    --
    90(a)
    1 ↔ 1
    1(244472758-244495896)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC059964.12   -- 78.2(n)    BC059964.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc733272 hypothetical protein MGC73327 76.59(n)   393763  BC059647.1 


    ENSEMBL Gene Tree for AIDA (if available)
    TreeFam Gene Tree for AIDA (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AIDA gene

    AIDA for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for AIDA
    PGOHUM00000234838 PGOHUM00000240579 PGOHUM00000246117


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/647 NCBI SNPs in AIDA are shown (see all 647    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1130910711,2
    C--193525542(+) TGGGGG/TGTGTG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs727401161,2
    C--193558297(+) CAGAAC/TGGGTA 1 -- us2k10--------
    rs1116041401,2
    C--193558461(+) AAATCC/TCAGAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs750831181,2
    C,F--193558830(+) TGGGGG/AAGGCC 1 -- us2k11Minor allele frequency- A:0.04EA 120
    rs731248931,2
    C--193558866(+) TCATAC/TTCAGT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs754494271,2
    --193559160(+) GAGGGC/TGTGGA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs762322641,2
    C,F--193559463(+) CCTACG/ACATGG 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs11414671,2
    C--193559746(-) CCGCTC/TTCTGG 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs285835561,2
    C--193560206(+) CCACAA/GCCAAA 1 -- us2k10--------
    rs771107991,2
    --193560546(+) TCCTGG/CTTTTC 1 -- ut511Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for AIDA (222841355 - 222886552 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for AIDA: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AIDA
    DNA2.0 Custom Variant and Variant Library Synthesis for AIDA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    AIDA for disorders           About GeneDecksing

    OMIM gene information: 612375    OMIM disorders: --

    2 diseases for AIDA:    About MalaCards
    mumps    diarrhea


    Export disorders for AIDA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AIDA gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with AIDA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. (PubMed id 17681137)1, 2, 3 Rui Y....Lin S.C. (2007)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
    4. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64853 HGNC: 25761 AceView: FLJ12806 Ensembl:ENSG00000186063 euGenes: HUgn64853
    ECgene: AIDA H-InvDB: AIDA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AIDA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AIDA gene:
    Search GeneIP for patents involving AIDA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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