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Aliases for AIDA Gene

Aliases for AIDA Gene

  • Axin Interactor, Dorsalization Associated 2 3
  • Axin Interaction Partner And Dorsalization Antagonist 2 3 4
  • C1orf80 3 4
  • Axin Interactor, Dorsalization-Associated Protein 3
  • Chromosome 1 Open Reading Frame 80 2

External Ids for AIDA Gene

Previous Symbols for AIDA Gene

  • C1orf80

Summaries for AIDA Gene

GeneCards Summary for AIDA Gene

AIDA (Axin Interactor, Dorsalization Associated) is a Protein Coding gene. GO annotations related to this gene include protein domain specific binding.

UniProtKB/Swiss-Prot for AIDA Gene

  • Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AIDA Gene

Genomics for AIDA Gene

Genomic Location for AIDA Gene

Start:
222,668,013 bp from pter
End:
222,713,210 bp from pter
Size:
45,198 bases
Orientation:
Minus strand

Genomic View for AIDA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AIDA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AIDA Gene

Regulatory Elements for AIDA Gene

Proteins for AIDA Gene

  • Protein details for AIDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BJ3-AIDA_HUMAN
    Recommended name:
    Axin interactor, dorsalization-associated protein
    Protein Accession:
    Q96BJ3
    Secondary Accessions:
    • A8K1F0
    • Q49A81
    • Q5JRA4
    • Q658P1
    • Q9H9E8

    Protein attributes for AIDA Gene

    Size:
    306 amino acids
    Molecular mass:
    35023 Da
    Quaternary structure:
    • Interacts with AXIN1.

    Alternative splice isoforms for AIDA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AIDA Gene

Proteomics data for AIDA Gene at MOPED

Post-translational modifications for AIDA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AIDA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AIDA Gene

Domains for AIDA Gene

Protein Domains for AIDA Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

AIDA_HUMAN
Family:
  • Belongs to the AIDA family.:
    • Q96BJ3
genes like me logo Genes that share domains with AIDA: view

No data available for Gene Families for AIDA Gene

Function for AIDA Gene

Molecular function for AIDA Gene

UniProtKB/Swiss-Prot Function: Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).

Gene Ontology (GO) - Molecular Function for AIDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with AIDA: view

miRNA for AIDA Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AIDA Gene

Localization for AIDA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AIDA Gene COMPARTMENTS Subcellular localization image for AIDA gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for AIDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with AIDA: view

Pathways for AIDA Gene

SuperPathways for AIDA Gene

No Data Available

Gene Ontology (GO) - Biological Process for AIDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009953 dorsal/ventral pattern formation ISS --
GO:0043496 regulation of protein homodimerization activity ISS --
GO:0043508 negative regulation of JUN kinase activity IDA 17681137
GO:0046329 negative regulation of JNK cascade ISS --
genes like me logo Genes that share ontologies with AIDA: view

No data available for Pathways by source for AIDA Gene

Transcripts for AIDA Gene

Unigene Clusters for AIDA Gene

Axin interactor, dorsalization associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AIDA Gene

No ASD Table

Relevant External Links for AIDA Gene

GeneLoc Exon Structure for
AIDA
ECgene alternative splicing isoforms for
AIDA

Expression for AIDA Gene

mRNA expression in normal human tissues for AIDA Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AIDA Gene

SOURCE GeneReport for Unigene cluster for AIDA Gene Hs.156625

mRNA Expression by UniProt/SwissProt for AIDA Gene

Q96BJ3-AIDA_HUMAN
Tissue specificity: Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle.
genes like me logo Genes that share expressions with AIDA: view

Orthologs for AIDA Gene

This gene was present in the common ancestor of chordates.

Orthologs for AIDA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AIDA 36
  • 99.78 (n)
  • 100 (a)
AIDA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AIDA 36
  • 96.62 (n)
  • 99.67 (a)
AIDA 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AIDA 36
  • 95.53 (n)
  • 98.69 (a)
AIDA 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aida 36
  • 93.01 (n)
  • 96.39 (a)
Aida 16
Aida 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AIDA 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AIDA 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aida 36
  • 91.91 (n)
  • 96.72 (a)
chicken
(Gallus gallus)
Aves AIDA 36
  • 87.15 (n)
  • 95.1 (a)
AIDA 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AIDA 37
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76000 36
zebrafish
(Danio rerio)
Actinopterygii aida 36
  • 74.04 (n)
  • 82.51 (a)
aida 37
  • 83 (a)
OneToOne
zgc73327 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 48 (a)
OneToOne
Species with no ortholog for AIDA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AIDA Gene

ENSEMBL:
Gene Tree for AIDA (if available)
TreeFam:
Gene Tree for AIDA (if available)

Paralogs for AIDA Gene

Pseudogenes.org Pseudogenes for AIDA Gene

genes like me logo Genes that share paralogs with AIDA: view

No data available for Paralogs for AIDA Gene

Variants for AIDA Gene

Sequence variations from dbSNP and Humsavar for AIDA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs766946 -- 222,670,158(-) AAATT(A/G)AACCT reference, missense
rs951349 -- 222,678,508(+) CATTT(C/T)TTTCT intron-variant
rs1391558 -- 222,674,687(-) ACCAT(A/G)CACAA intron-variant
rs1546214 -- 222,701,510(+) CAAAA(A/T)TTAGG intron-variant
rs2030076 -- 222,701,624(+) TTTCC(A/G)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AIDA Gene

Variant ID Type Subtype PubMed ID
nsv873205 CNV Loss 21882294
esv270291 CNV Insertion 20981092
esv271687 CNV Insertion 20981092
esv272318 CNV Insertion 20981092
esv1787433 CNV Insertion 17803354

Relevant External Links for AIDA Gene

HapMap Linkage Disequilibrium report
AIDA

Disorders for AIDA Gene

No disorders were found for AIDA Gene.

No data available for UniProtKB/Swiss-Prot for AIDA Gene

Publications for AIDA Gene

  1. A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. (PMID: 17681137) Rui Y. … Lin S.-C. (Dev. Cell 2007) 2 3 4
  2. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for AIDA Gene

Sources for AIDA Gene

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