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Aliases for AIDA Gene

Aliases for AIDA Gene

  • Axin Interactor, Dorsalization Associated 2 3 5
  • Axin Interaction Partner And Dorsalization Antagonist 2 3 4
  • C1orf80 3 4
  • Axin Interactor, Dorsalization-Associated Protein 3
  • Chromosome 1 Open Reading Frame 80 2

External Ids for AIDA Gene

Previous HGNC Symbols for AIDA Gene

  • C1orf80

Previous GeneCards Identifiers for AIDA Gene

  • GC01M220907
  • GC01M222841
  • GC01M193515

Summaries for AIDA Gene

GeneCards Summary for AIDA Gene

AIDA (Axin Interactor, Dorsalization Associated) is a Protein Coding gene. GO annotations related to this gene include protein domain specific binding.

UniProtKB/Swiss-Prot for AIDA Gene

  • Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AIDA Gene

Genomics for AIDA Gene

Regulatory Elements for AIDA Gene

Enhancers for AIDA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F222653 1.5 FANTOM5 Ensembl ENCODE 11.9 +58.7 58675 2.8 PKNOX1 TBL1XR1 RAD21 CBX5 ZNF143 ETV6 CREM ZNF263 ZNF362 CBFB BROX ENSG00000272750 AIDA TLR5 ENSG00000229399
GH01F222657 0.4 FANTOM5 11.9 +55.8 55848 0.2 ZNF366 AIDA BROX TAF1A MIA3 ENSG00000272750 ENSG00000229399
GH01F222732 0.8 ENCODE 0.3 -19.4 -19444 0.2 TBL1XR1 GTF2E2 BMI1 EBF1 RELA FOSL1 CBX5 ETV6 RCOR1 CREM GC01P222732 AIDA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AIDA on UCSC Golden Path with GeneCards custom track

Promoters for AIDA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000553690 610 4001 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for AIDA Gene

Chromosome:
1
Start:
222,668,013 bp from pter
End:
222,713,210 bp from pter
Size:
45,198 bases
Orientation:
Minus strand

Genomic View for AIDA Gene

Genes around AIDA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AIDA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AIDA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AIDA Gene

Proteins for AIDA Gene

  • Protein details for AIDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BJ3-AIDA_HUMAN
    Recommended name:
    Axin interactor, dorsalization-associated protein
    Protein Accession:
    Q96BJ3
    Secondary Accessions:
    • A8K1F0
    • Q49A81
    • Q5JRA4
    • Q658P1
    • Q9H9E8

    Protein attributes for AIDA Gene

    Size:
    306 amino acids
    Molecular mass:
    35023 Da
    Quaternary structure:
    • Interacts with AXIN1.

    Alternative splice isoforms for AIDA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AIDA Gene

Post-translational modifications for AIDA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AIDA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AIDA Gene

Domains & Families for AIDA Gene

Protein Domains for AIDA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AIDA Gene

Graphical View of Domain Structure for InterPro Entry

Q96BJ3

UniProtKB/Swiss-Prot:

AIDA_HUMAN :
  • Belongs to the AIDA family.
Family:
  • Belongs to the AIDA family.
genes like me logo Genes that share domains with AIDA: view

No data available for Gene Families for AIDA Gene

Function for AIDA Gene

Molecular function for AIDA Gene

UniProtKB/Swiss-Prot Function:
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).

Gene Ontology (GO) - Molecular Function for AIDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019904 protein domain specific binding IEA --
GO:0035091 phosphatidylinositol binding IBA --
genes like me logo Genes that share ontologies with AIDA: view
genes like me logo Genes that share phenotypes with AIDA: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AIDA Gene

Localization for AIDA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AIDA gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for AIDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IBA --
genes like me logo Genes that share ontologies with AIDA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for AIDA Gene

Pathways & Interactions for AIDA Gene

No Data Available

Gene Ontology (GO) - Biological Process for AIDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0009953 dorsal/ventral pattern formation ISS --
GO:0043496 regulation of protein homodimerization activity ISS --
GO:0043508 negative regulation of JUN kinase activity IDA 17681137
GO:0046329 negative regulation of JNK cascade ISS --
genes like me logo Genes that share ontologies with AIDA: view

No data available for Pathways by source and SIGNOR curated interactions for AIDA Gene

Drugs & Compounds for AIDA Gene

(7) Drugs for AIDA Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Idarubicin Approved Pharma 210
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1518
Tretinoin Approved, Investigational Nutra 220
6-Mercaptopurine Pharma 199
Anti-Bacterial Agents Pharma 10884
genes like me logo Genes that share compounds with AIDA: view

Transcripts for AIDA Gene

Unigene Clusters for AIDA Gene

Axin interactor, dorsalization associated:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AIDA Gene

No ASD Table

Relevant External Links for AIDA Gene

GeneLoc Exon Structure for
AIDA
ECgene alternative splicing isoforms for
AIDA

Expression for AIDA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AIDA Gene

Protein differential expression in normal tissues from HIPED for AIDA Gene

This gene is overexpressed in Uterus (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AIDA Gene



Protein tissue co-expression partners for AIDA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AIDA Gene:

AIDA

SOURCE GeneReport for Unigene cluster for AIDA Gene:

Hs.156625

mRNA Expression by UniProt/SwissProt for AIDA Gene:

Q96BJ3-AIDA_HUMAN
Tissue specificity: Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle.
genes like me logo Genes that share expression patterns with AIDA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AIDA Gene

Orthologs for AIDA Gene

This gene was present in the common ancestor of chordates.

Orthologs for AIDA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AIDA 34 35
  • 99.78 (n)
cow
(Bos Taurus)
Mammalia AIDA 35 34
  • 96.62 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AIDA 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AIDA 35 34
  • 95.53 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Aida 34 16 35
  • 93.01 (n)
rat
(Rattus norvegicus)
Mammalia Aida 34
  • 91.91 (n)
oppossum
(Monodelphis domestica)
Mammalia AIDA 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves AIDA 35 34
  • 87.15 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AIDA 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76000 34
zebrafish
(Danio rerio)
Actinopterygii aida 34 35
  • 74.04 (n)
zgc73327 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToOne
Species where no ortholog for AIDA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AIDA Gene

ENSEMBL:
Gene Tree for AIDA (if available)
TreeFam:
Gene Tree for AIDA (if available)

Paralogs for AIDA Gene

Pseudogenes.org Pseudogenes for AIDA Gene

genes like me logo Genes that share paralogs with AIDA: view

No data available for Paralogs for AIDA Gene

Variants for AIDA Gene

Sequence variations from dbSNP and Humsavar for AIDA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11118970 -- 222,689,554(+) ACATA(C/T)ATATG intron-variant
rs11118971 -- 222,689,565(+) TATAT(A/G)TATGT intron-variant
rs111260685 -- 222,682,947(+) TTTGT(A/T)TGAAT intron-variant
rs111301743 -- 222,683,900(+) AGAAA(C/G)GTAAG intron-variant
rs111319544 -- 222,712,827(+) TTTTC(A/C)GTCAC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for AIDA Gene

Variant ID Type Subtype PubMed ID
nsv945309 CNV duplication 23825009
esv3335605 CNV insertion 20981092
esv1787433 CNV insertion 17803354

Variation tolerance for AIDA Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AIDA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AIDA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AIDA Gene

Disorders for AIDA Gene

Relevant External Links for AIDA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AIDA

No disorders were found for AIDA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AIDA Gene

Publications for AIDA Gene

  1. A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. (PMID: 17681137) Rui Y. … Lin S.-C. (Dev. Cell 2007) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3 64
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for AIDA Gene

Sources for AIDA Gene

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