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AHSP Gene

protein-coding   GIFtS: 53
GCID: GC16P031540

Alpha Hemoglobin Stabilizing Protein

(Previous name: erythroid associated factor)
(Previous symbol: ERAF)
  See AHSP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Alpha Hemoglobin Stabilizing Protein1 2     Erythroid Differentiation-Related Factor2 3
ERAF1 2 3 5     Erythroid-Associated Factor2 3
EDRF2 3 5     Alpha-Hemoglobin-Stabilizing Protein2
Erythroid Associated Factor1 2     Erythroid Differentiation Associated Factor2
Alpha Hemoglobin Stabilising Protein1 2     

External Ids:    HGNC: 180751   Entrez Gene: 513272   Ensembl: ENSG000001698777   OMIM: 6058215   UniProtKB: Q9NZD43   

Export aliases for AHSP gene to outside databases

Previous GC identifers: GC16P031447 GC16P029099


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AHSP Gene:
AHSP (alpha hemoglobin stabilizing protein) is a protein-coding gene. Diseases associated with AHSP include obstructive lung disease, and angina pectoris. GO annotations related to this gene include unfolded protein binding and hemoglobin binding.

UniProtKB/Swiss-Prot: AHSP_HUMAN, Q9NZD4
Function: Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell
development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate
pathological states of alpha-hemoglobin excess such as beta-thalassemia

Gene Wiki entry for AHSP (ERAF) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_187260.1  NC_018927.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for AHSP
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAHSP promoter sequence
   Search Chromatin IP Primers for AHSP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AHSP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.1

AHSP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AHSP gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P031540:  view genomic region     (about GC identifiers)

Start:
31,539,185 bp from pter      End:
31,540,124 bp from pter
Size:
940 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AHSP_HUMAN, Q9NZD4 (See protein sequence)
Recommended Name: Alpha-hemoglobin-stabilizing protein  
Size: 102 amino acids; 11840 Da
Subunit: Monomer. Forms a heterodimer with free alpha-hemoglobin. Does not bind beta-hemoglobin nor
alpha(2)beta(2) hemoglobin A
Selected PDB 3D structures from and Proteopedia for AHSP (see all 8):
1W09 (3D)        1W0A (3D)        1W0B (3D)        1XZY (3D)        1Y01 (3D)        1Z8U (3D)    
Secondary accessions: Q8TD01

Explore the universe of human proteins at neXtProt for AHSP: NX_Q9NZD4

Explore proteomics data for AHSP at MOPED


See AHSP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_057717.1  
ENSEMBL proteins: 
 ENSP00000307199   ENSP00000456748  

AHSP Human Recombinant Protein Products:

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Novus Biologicals AHSP Lysate
Sino Biological Recombinant Protein for AHSP
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ProSpec Recombinant Protein for AHSP
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for AHSP 

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Abcam antibodies for AHSP
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LSBio Antibodies in human, mouse, rat for AHSP

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Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for AHSP 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR015317 A_Hb_stabilising_prot

Graphical View of Domain Structure for InterPro Entry Q9NZD4

ProtoNet protein and cluster: Q9NZD4

UniProtKB/Swiss-Prot: AHSP_HUMAN, Q9NZD4
Similarity: Belongs to the AHSP family


Find genes that share domains with AHSP           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: AHSP_HUMAN, Q9NZD4
Function: Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell
development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate
pathological states of alpha-hemoglobin excess such as beta-thalassemia
Induction: By GATA1 during erythroid maturation

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030492hemoglobin binding NAS12066189
GO:0051082unfolded protein binding NAS12066189
     
Find genes that share ontologies with AHSP           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for AHSP:
 Abundance of large cells with   Increased gamma-H2AX phosphory 

     5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ahsp):
 cellular  hematopoietic system  immune system  integument  mortality/aging 

Find genes that share phenotypes with AHSP           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for AHSP: Ahsptm1.1Mjwe Ahsptm1Mjwe

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AHSP
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AHSP

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AHSP
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AHSP

miRNA
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Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat AHSP

Gene Editing
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GenScript: all cDNA clones in your preferred vector: AHSP (NM_016633)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for AHSP
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHSP

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHSP


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
AHSP_HUMAN, Q9NZD4: Cytoplasm
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol5
nucleus2
cytoskeleton1
mitochondrion1
plasma membrane1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005833hemoglobin complex NAS12066189

Find genes that share ontologies with AHSP           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AHSP
Interactions:

    Search GeneGlobe Interaction Network for AHSP

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

Selected Interacting proteins for AHSP (Q9NZD42, 3 ENSP000003071994) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
InteractantInteraction Details
GeneCardExternal ID(s)
MYZAPP0CAP12, 3MINT-65214 I2D: score=4 
HBA1P699053, ENSP000003224214I2D: score=3 STRING: ENSP00000322421
HBA2P699053, ENSP000002515954I2D: score=3 STRING: ENSP00000251595
ZC3H12AQ5D1E83I2D: score=4 
POLR2MP0CAP23I2D: score=3 
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006457protein folding IEA--
GO:0020027hemoglobin metabolic process NAS12066189
GO:0030097hemopoiesis NAS12066189
GO:0050821protein stabilization IEA--

Find genes that share ontologies with AHSP           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for AHSP

Selected Novoseek inferred chemical compound relationships for AHSP gene (see all 67)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
nitric oxide 77.5 315 8107883 (4), 7743332 (4), 15714750 (4), 8845443 (2) (see all 99)
prostacyclin 77.4 80 1926869 (6), 7947609 (3), 8358552 (3), 2263533 (2) (see all 50)
cgmp 76.8 44 1311528 (4), 1868189 (2), 1794204 (2), 1318427 (2) (see all 27)
guanylate 75.5 22 1681884 (2), 1868189 (2), 8447442 (1), 8638522 (1) (see all 18)
l-nmma 69.8 17 7889260 (2), 1720843 (1), 7685446 (1), 1283343 (1) (see all 8)
arginine 69.3 54 1566916 (4), 8835314 (2), 1991651 (2), 1662618 (2) (see all 35)
nitroglycerin 66.9 23 8603131 (4), 1288910 (1), 8743501 (1), 16101430 (1) (see all 13)
acetylcholine 66.4 51 2344673 (5), 1566916 (3), 2032388 (3), 1629068 (2) (see all 29)
sodium nitroprusside 65.4 18 8603131 (2), 1311528 (2), 1288910 (1), 8767924 (1) (see all 12)
ng-nitro-l-arginine 62.7 20 1629068 (3), 8199652 (2), 1991651 (1), 7889260 (1) (see all 10)



Find genes that share compounds with AHSP           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for AHSP gene: 
NM_016633.2  

Unigene Cluster for AHSP:

Alpha hemoglobin stabilizing protein
Hs.274309  [show with all ESTs]
Unigene Representative Sequence: BI834180
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000302312(uc002ecj.3) ENST00000569954 ENST00000564707
miRNA
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Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for AHSP
Predesigned siRNA for gene silencing in human, mouse, rat AHSP
Clone
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OriGene clones in human, mouse for AHSP (see all 6)
OriGene ORF clones in mouse, rat for AHSP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: AHSP (NM_016633)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for AHSP
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHSP
Primer
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OriGene qPCR primer pairs and template standards for AHSP
OriGene qSTAR qPCR primer pairs in human, mouse for AHSP
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat AHSP
  QuantiTect SYBR Green Assays in human, mouse, rat AHSP
  QuantiFast Probe-based Assays in human, mouse, rat AHSP

Additional mRNA sequence: 

AF112995.1 AF147435.1 AF208865.1 AF364517.1 BC035842.1 

3 DOTS entries:

DT.100033632  DT.95130651  DT.95130637 

Selected AceView cDNA sequences (see all 92):

BG940214 BU658045 AI370497 N64110 BG943419 CR599801 CK300787 H52526 
H94264 BG942868 AA328577 H94872 BG942798 BC035842 BG943368 AA339867 
BG943964 T52214 H94920 BG944377 H94866 H50860 BG940046 R91558 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for AHSP    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:                              
SP2:                              


ECgene alternative splicing isoforms for AHSP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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AHSP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCCTTAGGCT
AHSP Expression
About this image


AHSP expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 7) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 3 entries
         Erythroblasts Hematopoietic Bone Marrow
         Bone marrow-derived hematopoietic stem cells (family)
 
 Fibroblasts
         Dermal Fibroblasts Dorsal Dermis
 
 Endothelium (Cardiovascular System)
         Extraembryonic Angioblasts Extraembryonic Capillary Plexus
 
 Extraembryonic Mesoderm (Extraembryonic Tissues)
         Extraembryonic Angioblasts Extraembryonic Capillary Plexus
 
 Bone (Muscoskeletal System)
         Bone Marrow
AHSP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

AHSP Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.274309

UniProtKB/Swiss-Prot: AHSP_HUMAN, Q9NZD4
Tissue specificity: Expressed in blood and bone marrow

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QuantiFast Probe-based Assays in human, mouse, rat AHSP
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHSP

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for AHSP gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ahsp5 alpha hemoglobin stabilizing protein   --   -


ENSEMBL Gene Tree for AHSP (if available)
TreeFam Gene Tree for AHSP (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for AHSP gene
1 SIMAP similar gene for AHSP using alignment to 2 protein entries:     AHSP_HUMAN (see all proteins):
ERAF

Find genes that share paralogs with AHSP           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for AHSP (see all 94)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs99296571,2
C--31537221(+) ctgccT/Acagcc 1 -- us2k12Minor allele frequency- A:0.25NA 4
rs99373671,2
C--31537222(+) tgcctC/Tagcct 1 -- us2k10--------
rs1456387131,2
--31537281(+) TTGTAG/TTTTTA 1 -- us2k10--------
rs1808400561,2
--31537325(+) GGTCTC/TGAACT 1 -- us2k10--------
rs72031991,2
C,F,A--31537574(+) TGTGTC/GCACTG 1 -- us2k19Minor allele frequency- G:0.34NA WA CSA EA 369
rs727905611,2
C,F--31537624(+) CTGACC/AAAAAA 1 -- us2k11Minor allele frequency- A:0.03NA 120
rs72020201,2
C,F,A,H--31537655(+) ATACTG/ATATGA 1 -- us2k1 tfbs321Minor allele frequency- A:0.32NS EA NA WA CSA 2311
rs133389391,2
C,F,H--31537804(+) tgtatC/Tttaac 1 -- us2k120Minor allele frequency- T:0.26NS EA NA WA CSA 2346
rs755084131,2
F--31537813(+) ACTGCG/ATTTGT 1 -- us2k11Minor allele frequency- A:0.02EA 120
rs1465601431,2
--31537927(+) GTCAGA/GAGTTC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for AHSP (31539185 - 31540124 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for AHSP:    About this table    
Variant IDTypeSubtypePubMed ID
esv2658959CNV Deletion23128226
esv2714195CNV Deletion23290073
dgv2673n71CNV Loss21882294
nsv905747CNV Gain21882294

Human Gene Mutation Database (HGMD): AHSP
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing AHSP
DNA2.0 Custom Variant and Variant Library Synthesis for AHSP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605821    OMIM disorders: --

13 diseases for AHSP:    
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obstructive lung disease    angina pectoris    myocardial stunning    variant creutzfeldt-jakob disease
beta thalassemia    cerebral malaria    hyperglycemia    creutzfeldt-jakob disease
acute myocardial infarction    essential hypertension    coronary artery disease    myocardial infarction
malaria

1 disease from the University of Copenhagen DISEASES database for AHSP:
Thalassemia

Find genes that share disorders with AHSP           About GenesLikeMe

Selected Novoseek inferred disease relationships for AHSP gene (see all 35)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
vasospasm 64.3 5 9402468 (1), 9515109 (1), 1717775 (1), 7568903 (1) (see all 5)
vascular dilation 56.9 2 1928200 (1), 1343264 (1)
atherosclerosis 53.9 20 7568903 (2), 2045172 (1), 1868189 (1), 8222147 (1) (see all 15)
coronary vasospasm 47.8 1 11543600 (1)
vascular diseases 42 5 14650203 (2), 1868189 (1), 1921472 (1)
beta-thalassemia 38.2 16 17874450 (3), 15545996 (2), 16696909 (2), 20063986 (2) (see all 5)
hypercholesterolemia 37.6 2 7568903 (1), 9340578 (1)
myocardial ischemia 37.2 5 8461525 (1), 2194809 (1), 7832112 (1), 10094179 (1)
thalassemia 34.6 8 14715623 (4), 20371604 (1), 17666592 (1)
hypertension pulmonary 30 4 1868189 (1), 1921472 (1), 2117136 (1), 1424046 (1)

Genetic Association Database (GAD): AHSP
Human Genome Epidemiology (HuGE) Navigator: AHSP (1 document)

Export disorders for AHSP gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for AHSP gene, integrated from 10 sources (see all 317):
(articles sorted by number of sources associating them with AHSP)
    Utopia: connect your pdf to the dynamic
world of online information

  1. An abundant erythroid protein that stabilizes free alpha- haemoglobin. (PubMed id 12066189)1, 2, 3 Kihm A.J.... Weiss M.J. (Nature 2002)
  2. A novel erythroid-specific marker of transmissible spongiform encephalopathies. (PubMed id 11231637)1, 2, 3 Miele G.... Clinton M. (Nat. Med. 2001)
  3. Molecular mechanism of AHSP-mediated stabilization of alpha- hemoglobin. (PubMed id 15550245)1, 2, 9 Feng L.... Shi Y. (Cell 2004)
  4. Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein. (PubMed id 12192002)1, 2, 9 Gell D.... Mackay J.P. (J. Biol. Chem. 2002)
  5. Analysis of alpha-hemoglobin-stabilizing protein (AHSP) gene as a genetic modifier to the phenotype of beta-thalassemia in Southern China. (PubMed id 20627634)1, 4 Wang Z....Xu X. (amp 2010)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
  8. Reduction of AHSP synthesis in hemin-induced K562 cells and EPO-induced CD34(+) cells leads to alpha-globin precipitation, impairment of normal hemoglobin production, and increased cell death. (PubMed id 18179859)1, 9 Pinho F.O....Costa F.F. (Exp. Hematol. 2008)
  9. The alpha-hemoglobin stabilizing protein and expression of unstable alpha-Hb variants. (PubMed id 19482015)1, 9 Vasseur C....Baudin-Creuza V. (Clin. Biochem. 2009)
  10. Population analysis of the alpha hemoglobin stabilizing protein (AHSP) gene identifies sequence variants that alter expression and function. (PubMed id 17874450)1, 9 dos Santos C.O....Weiss M.J. (Am. J. Hematol. 2008)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51327 HGNC: 18075 AceView: ERAF Ensembl:ENSG00000169877 euGenes: HUgn51327
ECgene: AHSP H-InvDB: AHSP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for AHSP Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for AHSP gene:
Search GeneIP for patents involving AHSP

GeneCards and IP:
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