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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AHSP Gene

protein-coding   GIFtS: 49
GCID: GC16P031540

alpha hemoglobin stabilizing protein

(Previous name: erythroid associated factor )
(Previous symbol: ERAF)
 Explore 32 diseases affiliated with
AHSP via our new
 Human Malady Compendium 
Biological research products
for AHSP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Alpha Hemoglobin Stabilizing Protein1 2     Erythroid-Associated Factor2 3
EDRF1 2 3 5     Alpha Hemoglobin Stabilising Protein2
ERAF1 2 3 5     Alpha-Hemoglobin-Stabilizing Protein2
Erythroid Associated Factor1 2     Erythroid Differentiation Associated Factor2
Erythroid Differentiation-Related Factor2 3     

External Ids:    HGNC: 180751   Entrez Gene: 513272   Ensembl: ENSG000001698777   OMIM: 6058215   UniProtKB: Q9NZD43   

Export aliases for AHSP gene to outside databases

Previous GC identifers: GC16P031447 GC16P029099


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: AHSP_HUMAN, Q9NZD4
Function: Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell
development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological
states of alpha-hemoglobin excess such as beta-thalassemia

Gene Wiki entry for AHSP (ERAF)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for AHSP
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAHSP promoter sequence
   Search SABiosciences Chromatin IP Primers for AHSP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AHSP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.1

AHSP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AHSP gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P031540:  view genomic region     (about GC identifiers)

Start:
31,539,185 bp from pter      End:
31,540,124 bp from pter
Size:
940 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AHSP_HUMAN, Q9NZD4 (See protein sequence)
Recommended Name: Alpha-hemoglobin-stabilizing protein  
Size: 102 amino acids; 11840 Da
Subunit: Monomer. Forms a heterodimer with free alpha-hemoglobin. Does not bind beta-hemoglobin nor alpha(2)beta(2)
hemoglobin A
Subcellular location: Cytoplasm
6/8 PDB 3D structures from and Proteopedia for AHSP (see all 8):
1W09 (3D)        1W0A (3D)        1W0B (3D)        1XZY (3D)        1Y01 (3D)        1Z8U (3D)    
Secondary accessions: Q8TD01

Explore the universe of human proteins at neXtProt for AHSP: NX_Q9NZD4

AHSP Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_057717.1  
ENSEMBL proteins: 
 ENSP00000307199   ENSP00000456748  

Human Recombinant Protein Products: 
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Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein: AHSP
OriGene Protein Over-expression Lysate: AHSP
OriGene Custom Protein Services for AHSP 
GenScript Custom Purified and Recombinant Proteins Services for AHSP
Novus Biologicals AHSP Proteins
Novus Biologicals AHSP Lysate
Browse Sino Biological Recombinant Proteins
ProSpec Recombinant Protein for AHSP
Browse Proteins at Uscn

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005833hemoglobin complex NAS12066189


AHSP for ontologies           About GeneDecksing



AHSP Antibody Products: 
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Search for Antibodies for AHSP at Abcam  
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Search ThermoFisher Antibodies for AHSP

Assay Products for AHSP: 
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GenScript Custom Assay Services for AHSP
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AHSP for domains           About GeneDecksing

1 InterPro domain/family:
 IPR015317 A_Hb_stabilising_prot

Graphical View of Domain Structure for InterPro Entry Q9NZD4

ProtoNet protein and cluster: Q9NZD4

UniProtKB/Swiss-Prot: AHSP_HUMAN, Q9NZD4
Similarity: Belongs to the AHSP family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: AHSP_HUMAN, Q9NZD4
Function: Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell
development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological
states of alpha-hemoglobin excess such as beta-thalassemia
Induction: By GATA1 during erythroid maturation

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AHSP
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AHSP
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AHSP (see all 4)
OriGene shRNA RFP: AHSP
OriGene siRNA: AHSP
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AHSP

Gene Editing
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Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AHSP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AHSP
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for AHSP
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHSP 

Cell Line
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In Situ Assay
Products:
   

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for AHSP

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030492hemoglobin binding NAS12066189
GO:0051082unfolded protein binding NAS12066189


AHSP for ontologies           About GeneDecksing


2 GenomeRNAi human phenotypes for AHSP:
 Abundance of large cells with   Increased gamma-H2AX phosphory 

Animal Models:
     Mouse knock-outs for AHSP: Ahsptm1.1Mjwe Ahsptm1Mjwe
     5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ahsp):
 cellular  hematopoietic system  immune system  integument  mortality/aging 

AHSP for phenotypes           About GeneDecksing


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AHSP

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/17 Interacting proteins for AHSP (Q9NZD42, 3 ENSP000003071994) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
InteractantInteraction Details
GeneCardExternal ID(s)
GCOM1P0CAP12, 3MINT-65214 I2D: score=4 
MYZAPP0CAP12, 3MINT-65214 I2D: score=4 
HBA1P699053, ENSP000003224214I2D: score=3 STRING: ENSP00000322421
HBA2P699053, ENSP000002515954I2D: score=3 STRING: ENSP00000251595
ZC3H12AQ5D1E83, ENSP000003621744I2D: score=4 STRING: ENSP00000362174
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006457protein folding IEA--
GO:0020027hemoglobin metabolic process NAS12066189
GO:0030097hemopoiesis NAS12066189
GO:0050821protein stabilization IEA--


AHSP for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

AHSP for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AHSP
10/67 Novoseek chemical compound relationships for AHSP gene (see all 67)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
nitric oxide 77.5 315 8107883 (4), 7743332 (4), 15714750 (4), 8845443 (2) (see all 99)
prostacyclin 77.4 80 1926869 (6), 7947609 (3), 8358552 (3), 2263533 (2) (see all 50)
cgmp 76.8 44 1311528 (4), 1868189 (2), 1794204 (2), 1318427 (2) (see all 27)
guanylate 75.5 22 1681884 (2), 1868189 (2), 8447442 (1), 8638522 (1) (see all 18)
l-nmma 69.8 17 7889260 (2), 1720843 (1), 7685446 (1), 1283343 (1) (see all 8)
arginine 69.3 54 1566916 (4), 8835314 (2), 1991651 (2), 1662618 (2) (see all 35)
nitroglycerin 66.9 23 8603131 (4), 1288910 (1), 8743501 (1), 16101430 (1) (see all 13)
acetylcholine 66.4 51 2344673 (5), 1566916 (3), 2032388 (3), 1629068 (2) (see all 29)
sodium nitroprusside 65.4 18 8603131 (2), 1311528 (2), 1288910 (1), 8767924 (1) (see all 12)
ng-nitro-l-arginine 62.7 20 1629068 (3), 8199652 (2), 1991651 (1), 7889260 (1) (see all 10)

Search CenterWatch for drugs/clinical trials and news about AHSP 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AHSP gene: 
NM_016633.2  

Unigene Cluster for AHSP:

Alpha hemoglobin stabilizing protein
Hs.274309  [show with all ESTs]
Unigene Representative Sequence: BI834180
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000302312(uc002ecj.3) ENST00000569954 ENST00000564707

miRNA
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OriGene 3'-UTR Clone: AHSP
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AHSP
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AHSP
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AHSP (see all 4)
OriGene shRNA RFP: AHSP
OriGene siRNA: AHSP
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AHSP
Clone
Products:
     
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AHSP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AHSP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: AHSP (NM_016633)
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Primer
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OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AHSP
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AHSP
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AHSP

Additional cDNA sequence: 

AF112995.1 AF147435.1 AF208865.1 AF364517.1 BC035842.1 

3 DOTS entries:

DT.100033632  DT.95130651  DT.95130637 

24/92 AceView cDNA sequences (see all 92):

AI370497 BU658045 BG943419 BG940214 CR599801 N64110 H94920 AF364517 
BG940046 R91558 BG943368 BG942782 CK300787 BQ189659 H52289 AF208865 
BG944377 BC035842 BG942868 AA328577 C21225 H94925 AA338152 H94866 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for AHSP    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:                              
SP2:                              


ECgene alternative splicing isoforms for AHSP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AHSP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTTAGGCT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See AHSP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AHSP

SOURCE GeneReport for Unigene cluster: Hs.274309

UniProtKB/Swiss-Prot: AHSP_HUMAN, Q9NZD4
Tissue specificity: Expressed in blood and bone marrow

    SABiosciences Custom PCR Arrays for AHSP
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AHSP
In Situ
Assay Products:
 

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for AHSP

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for AHSP gene from 1/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ahsp5 alpha hemoglobin stabilizing protein   --   -


ENSEMBL Gene Tree for AHSP (if available)
TreeFam Gene Tree for AHSP (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/75 NCBI SNPs in AHSP are shown (see all 75    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs99296571,2
C,--31537221(+) CTGCCT/ACAGCC 1 -- us2k12Minor allele frequency- A:0.25NA 4
rs99373671,2
C,--31537222(+) TGCCTC/TAGCCT 1 -- us2k10--------
rs1456387131,2
--31537281(+) TTGTAG/TTTTTA 1 -- us2k10--------
rs1808400561,2
--31537325(+) GGTCTC/TGAACT 1 -- us2k10--------
rs72031991,2
C,F,A,--31537574(+) TGTGTC/GCACTG 1 -- us2k19Minor allele frequency- G:0.34NA WA CSA EA 369
rs727905611,2
C,F,--31537624(+) CTGACC/AAAAAA 1 -- us2k11Minor allele frequency- A:0.03NA 120
rs72020201,2
C,F,A,H,--31537655(+) ATACTG/ATATGA 1 -- us2k1 tfbs321Minor allele frequency- A:0.32NS EA NA WA CSA 2311
rs133389391,2
C,F,H,--31537804(+) TGTATC/TTTAAC 1 -- us2k120Minor allele frequency- T:0.26NS EA NA WA CSA 2346
rs755084131,2
F,--31537813(+) ACTGCG/ATTTGT 1 -- us2k11Minor allele frequency- A:0.02EA 120
rs1465601431,2
--31537927(+) GTCAGA/GAGTTC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for AHSP (31539185 - 31540124 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for AHSP: --
Human Gene Mutation Database (HGMD): AHSP

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AHSP
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

AHSP for disorders           About GeneDecksing

OMIM gene information: 605821    OMIM disorders: --

20/32 diseases for AHSP (see all 32):    About MalaCards
variant creutzfeldt-jakob disease    beta thalassemia    myocardial infarction    acute myocardial infarction
congestive heart failure    myocardial stunning    amyotrophic lateral sclerosis    thalassemia
essential hypertension    lateral sclerosis    arteriosclerosis    hellp syndrome
vascular disease    obstructive lung disease    hypercholesterolemia    hypertension
hyperglycemia    thrombosis    diabetes mellitus    ischemia

1 disease from the University of Copenhagen DISEASES database for AHSP:
Thalassemia

10/35 Novoseek disease relationships for AHSP gene (see all 35)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
vasospasm 64.3 5 9402468 (1), 9515109 (1), 1717775 (1), 7568903 (1) (see all 5)
vascular dilation 56.9 2 1928200 (1), 1343264 (1)
atherosclerosis 53.9 20 7568903 (2), 2045172 (1), 1868189 (1), 8222147 (1) (see all 15)
coronary vasospasm 47.8 1 11543600 (1)
vascular diseases 42 5 14650203 (2), 1868189 (1), 1921472 (1)
beta-thalassemia 38.2 16 17874450 (3), 15545996 (2), 16696909 (2), 20063986 (2) (see all 5)
hypercholesterolemia 37.6 2 7568903 (1), 9340578 (1)
myocardial ischemia 37.2 5 8461525 (1), 2194809 (1), 7832112 (1), 10094179 (1)
thalassemia 34.6 8 14715623 (4), 20371604 (1), 17666592 (1)
hypertension pulmonary 30 4 1868189 (1), 1921472 (1), 2117136 (1), 1424046 (1)

Human Genome Epidemiology (HuGE) Navigator: AHSP (1 document)

Export disorders for AHSP gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for AHSP gene, integrated from 9 sources (see all 314):
(articles sorted by number of sources associating them with AHSP)
    Utopia: connect your pdf to the dynamic
world of online information

  1. An abundant erythroid protein that stabilizes free alpha- haemoglobin. (PubMed id 12066189)1, 2, 3 Kihm A.J.... Weiss M.J. (2002)
  2. A novel erythroid-specific marker of transmissible spongiform encephalopathies. (PubMed id 11231637)1, 2, 3 Miele G.... Clinton M. (2001)
  3. Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin. (PubMed id 15550245)1, 2, 9 Feng L....Shi Y. (2004)
  4. Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein. (PubMed id 12192002)1, 2, 9 Gell D.... Mackay J.P. (2002)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  6. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
  7. Reduction of AHSP synthesis in hemin-induced K562 cells and EPO-induced CD34(+) cells leads to alpha-globin precipitation, impairment of normal hemoglobin production, and increased cell death. (PubMed id 18179859)1, 9 Pinho F.O....Costa F.F. (2008)
  8. The alpha-hemoglobin stabilizing protein and expressi on of unstable alpha-Hb variants. (PubMed id 19482015)1, 9 Vasseur C....Baudin-Creuza V. (2009)
  9. Population analysis of the alpha hemoglobin stabilizing protein (AHSP) gene identifies sequence variants that alter expression and function. (PubMed id 17874450)1, 9 dos Santos C.O....Weiss M.J. (2008)
  10. GATA-1 and Oct-1 are required for expression of the human alpha-hemoglobin-stabilizing protein gene. (PubMed id 16186125)1, 9 Gallagher P.G....Bodine D.M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51327 HGNC: 18075 AceView: ERAF Ensembl:ENSG00000169877 euGenes: HUgn51327
ECgene: AHSP H-InvDB: AHSP

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for AHSP Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for AHSP gene:
Search GeneIP for patents involving AHSP

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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In Situ Hybridization Assays from
Advanced Cell Diagnostics
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