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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AHSG Gene

protein-coding   GIFtS: 62
GCID: GC03P186330

Alpha-2-HS-Glycoprotein

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
alpha-2-HS-glycoprotein1 2     ba-alpha-2-glycoprotein2
FETUA2 3     fetuin-A2
A2HS2     Alpha-2-Z-globulin3
AHS2     Ba-alpha-2-glycoprotein3
HSGA2     Fetuin-A3
alpha-2-Z-globulin2     

External Ids:    HGNC: 3491   Entrez Gene: 1972   Ensembl: ENSG000001451927   OMIM: 1386805   UniProtKB: P027653   

Export aliases for AHSG gene to outside databases

Previous GC identifers: GC03P183102 GC03P187587 GC03P187732 GC03P187651 GC03P187813 GC03P183739


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AHSG Gene:
Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG
molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA.
It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The
protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic
matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its
exact significance is still obscure. (provided by RefSeq, Jul 2008)

GeneCards Summary for AHSG Gene: 
AHSG (alpha-2-HS-glycoprotein) is a protein-coding gene. Diseases associated with AHSG include uremia, and liver cirrhosis, and among its related super-pathways are Signaling by BMP. GO annotations related to this gene include kinase inhibitor activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is FETUB.

UniProtKB/Swiss-Prot: FETUA_HUMAN, P02765
Function: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows
affinity for calcium and barium ions

Gene Wiki entry for AHSG ('2-HS-glycoprotein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AHSG gene promoter:
         AML1a   NF-kappaB   E4BP4   GATA-1   FOXL1   C/EBPalpha   SRY   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAHSG promoter sequence
   Search SABiosciences Chromatin IP Primers for AHSG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AHSG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q27.3

AHSG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AHSG gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P186330:  view genomic region     (about GC identifiers)

Start:
186,330,712 bp from pter      End:
186,339,107 bp from pter
Size:
8,396 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FETUA_HUMAN, P02765 (See protein sequence)
Recommended Name: Alpha-2-HS-glycoprotein precursor  
Size: 367 amino acids; 39325 Da
Subunit: Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two
chains A and B are held together by a single disulfide bond
Subcellular location: Secreted
Secondary accessions: A8K9N6 B2R7G1 O14961 O14962 Q9P152

Explore the universe of human proteins at neXtProt for AHSG: NX_P02765

Explore proteomics data for AHSG at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation sites are present in the extracellular medium
  • UniProtKB: O- and N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan at Asn-156: Hex5HexNAc4;
    N-glycan heterogeneity at Asn-176: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P02765

  • AHSG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AHSG Protein Expression
    REFSEQ proteins: NP_001613.2  
    ENSEMBL proteins: 
     ENSP00000393887   ENSP00000273784  

    Human Recombinant Protein Products for AHSG: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for AHSG (Fetuin A/AHSG)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for AHSG
    OriGene Protein Over-expression Lysate for AHSG
    OriGene MassSpec for AHSG 
    OriGene Custom Protein Services for AHSG
    GenScript Custom Purified and Recombinant Proteins Services for AHSG
    Novus Biologicals AHSG Proteins
    Novus Biologicals AHSG Lysates
    Sino Biological Recombinant Protein for AHSG
    Sino Biological Cell Lysate for AHSG 
    ProSpec Recombinant Protein for AHSG
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space NAS11922920

    AHSG for ontologies           About GeneDecksing



    AHSG Antibody Products: 
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    GenScript Custom Superior Antibodies Services for AHSG
    Novus Biologicals AHSG Antibodies
    Abcam antibodies for AHSG
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for AHSG
    LSBio Antibodies in human, mouse, rat for AHSG 

    Assay Products for AHSG: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AHSG
    R&D Systems ELISAs for AHSG (Fetuin A/AHSG)         (see all)
    GenScript Custom Assay Services for AHSG
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001363 Prot_inh_fetuin_CS
     IPR000010 Prot_inh_cystat
     IPR025760 Cystatin_Fetuin_A

    Graphical View of Domain Structure for InterPro Entry P02765

    ProtoNet protein and cluster: P02765

    1 Blocks protein domain: IPB000010 Cysteine protease inhibitor

    UniProtKB/Swiss-Prot: FETUA_HUMAN, P02765
    Similarity: Belongs to the fetuin family
    Similarity: Contains 2 cystatin fetuin-A-type domains


    AHSG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FETUA_HUMAN, P02765
    Function: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows
    affinity for calcium and barium ions

         Genatlas biochemistry entry for AHSG:
    HS-glycoprotein,alpha-2-,inhibitor of the insulin-receptor tyrosine kinase,pp63 (cystatin superfamily)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004869cysteine-type endopeptidase inhibitor activity IEA--
    GO:0019210kinase inhibitor activity NAS12203945
         
    AHSG for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ahsg):
     growth/size  homeostasis/metabolism  muscle 

    AHSG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ahsgtm1Mbl for AHSG

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AHSG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AHSG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AHSG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AHSG 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AHSG
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate AHSG:
    hsa-miR-1248 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidAHSG 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AHSG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AHSG

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for AHSG
    Sirion Biotech Customized adenovirus for overexpression of AHSG

    Clone
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    OriGene ORF clones in mouse, rat for AHSG
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    GenScript: all cDNA clones in your preferred vector: AHSG (NM_001622)
    Sino Biological Human cDNA Clone for AHSG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AHSG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHSG
    Sirion Biotech Customized lentivirus for stable overexpression of AHSG 
                         Customized lentivirus expression plasmids for stable overexpression of AHSG 

    Cell Line
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    Search LifeMap BioReagents cell lines for AHSG
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHSG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AHSG About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by BMP
    BMP receptor signaling0.31
    2Glucose / Energy Metabolism
    Glucose / Energy Metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for AHSG
        Glucose / Energy Metabolism

    1 BioSystems Pathway for AHSG
        BMP receptor signaling




    AHSG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AHSG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/27 Interacting proteins for AHSG (P027651, 2, 3 ENSP000003938874) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005191, 2, 3, ENSP000003614234EBI-1223374,EBI-375543 MINT-8110347 I2D: score=3 STRING: ENSP00000361423
    DCNP075853, ENSP000000527544I2D: score=2 STRING: ENSP00000052754
    NR3C1P041503, ENSP000002315094I2D: score=1 STRING: ENSP00000231509
    FBXO2Q9UK223, ENSP000003462404I2D: score=2 STRING: ENSP00000346240
    INSRP062133, ENSP000003038304I2D: score=2 STRING: ENSP00000303830
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development NAS12153747
    GO:0001503ossification IEA--
    GO:0006907pinocytosis NAS12773197
    GO:0006953acute-phase response IDA12153747
    GO:0030500regulation of bone mineralization NAS3474608

    AHSG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AHSG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AHSG (FETUA)

    1 HMDB Compound for AHSG    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    10/16 Novoseek inferred chemical compound relationships for AHSG gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    saci 71.6 3 15917161 (1), 12914574 (1), 16117875 (1)
    kininogen 58.1 9 19273244 (1), 2107324 (1), 7736783 (1)
    apai 43.2 2 12914574 (1), 16117875 (1)
    polyacrylamide 40.4 13 1504002 (1), 7662613 (1), 8738346 (1), 2312128 (1) (see all 8)
    xbai 31.6 2 12914574 (1), 16117875 (1)
    tyrosine 29.2 12 9503031 (3), 1707273 (2), 9602019 (1), 7906861 (1) (see all 9)
    cysteine 28.4 4 1689725 (1), 1372866 (1), 17010978 (1), 8866020 (1)
    hydroxyapatite 26 1 15592877 (1)
    hydroxyproline 21.9 1 1845868 (1)
    calcium oxalate 20.9 1 8619372 (1)

    Search CenterWatch for drugs/clinical trials and news about AHSG / FETUA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AHSG gene: 
    NM_001622.2  

    Unigene Cluster for AHSG:

    Alpha-2-HS-glycoprotein
    Hs.324746  [show with all ESTs]
    Unigene Representative Sequence: NM_001622
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000411641(uc003fqk.4) ENST00000273784 ENST00000478441(uc003fqj.3)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AHSG
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate AHSG:
    hsa-miR-1248 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidAHSG 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AHSG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AHSG
    Clone
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    OriGene clones in human, mouse for AHSG (see all 8)
    OriGene ORF clones in mouse, rat for AHSG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AHSG (NM_001622)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AHSG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHSG
    Sirion Biotech Customized lentivirus for stable overexpression of AHSG 
                         Customized lentivirus expression plasmids for stable overexpression of AHSG 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AHSG
    OriGene qSTAR qPCR primer pairs in human, mouse for AHSG
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AHSG
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AHSG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AHSG

    Additional mRNA sequence: 

    AK292751.1 AK298447.1 AK303754.1 AK312969.1 BC048198.1 BC052590.1 D67012.1 M16961.1 

    22 DOTS entries:

    DT.419026  DT.100887723  DT.100887750  DT.100770454  DT.100887731  DT.100887742  DT.120890675  DT.406927 
    DT.437637  DT.100887741  DT.100887730  DT.120890669  DT.120890674  DT.120890691  DT.91753824  DT.100032673 
    DT.100887722  DT.100887762  DT.120890689  DT.91768644  DT.91768648  DT.120890657 

    24/533 AceView cDNA sequences (see all 533):

    AU121295 CR601433 CR607622 BQ644376 CR609433 CR590983 CR592598 CR615840 
    CB154104 CB141738 CB162645 CR600033 CR599704 CB137662 BX426937 CR590483 
    CR600789 AV659884 AV652906 AL564611 CR616960 CR606631 AV659532 CR600361 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for AHSG (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
    SP1:                                -                                       
    SP2:                                -                                       
    SP3:                                -                                       
    SP4:                                -                                       
    SP5:                                                                        


    ECgene alternative splicing isoforms for AHSG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AHSG expression in normal human tissues (normalized intensities)      AHSG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGTGTTCT
    AHSG Expression
    About this image


    AHSG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 6 entries
             Atrioventricular Node Cells Atrioventricular Node
             Left Ventricle
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...
     
     Limb (Muscoskeletal System)    fully expand to see all 6 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod
             limb/hindlimb/leg   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             cavities and their linings/intraembryonic coelom/diaphragm   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Long Bone
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...

    See AHSG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AHSG

    SOURCE GeneReport for Unigene cluster: Hs.324746

    UniProtKB/Swiss-Prot: FETUA_HUMAN, P02765
    Tissue specificity: Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is
    also found in dentin in much higher quantities than other plasma proteins

        SABiosciences Expression via Pathway-Focused PCR Arrays including AHSG: 
              Osteogenesis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AHSG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHSG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AHSG gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ahsg1 , 5 alpha-2-HS-glycoprotein1, 5 72.56(n)1
    62.61(a)1
      16 (13.74 cM)5
    116251  NM_013465.11  NP_038493.11 
     228920425 
    chicken
    (Gallus gallus)
    Aves AHSG1 alpha-2-HS-glycoprotein 48.08(n)
    41.89(a)
      424956  XM_422764.3  XP_422764.1 
    lizard
    (Anolis carolinensis)
    Reptilia AHSG6
    alpha-2-HS-glycoprotein
    35(a)
    1 ↔ 1
    GL343321.1(218916-262352)
    zebrafish
    (Danio rerio)
    Actinopterygii ahsg1 alpha-2-HS-glycoprotein 46.67(n)
    35.51(a)
      569558  NM_212622.1  NP_997787.1 


    ENSEMBL Gene Tree for AHSG (if available)
    TreeFam Gene Tree for AHSG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AHSG gene
    FETUB2  

    AHSG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: FETUA_HUMAN, P02765
    Polymorphism: There are two common alleles, AHSG*1 and AHSG*2. AHSG*1 has Thr-248/Thr-256; AHSG*2 has
    Met-248/Ser-256


    10/329 SNPs in AHSG are shown (see all 329)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs49171,2,4
    C,F,A,Hother1186206756(+) CTGCAC/TGGTGT 2 T M mis138Minor allele frequency- T:0.30MN EA NA NS WA CSA EU 8937
    rs49181,2,4
    C,F,Hother1186207425(+) CGTGAC/GCTCAC 2 T S mis134Minor allele frequency- G:0.34NA EA MN NS WA CSA EU 7572
    rs350942351,2
    C,F--186197995(+) CCAGGG/TCTTAT 1 -- us2k111Minor allele frequency- T:0.23NA WA CSA EA 373
    rs26814281,2
    C,F--186198036(+) CAGGTT/GTGTGC 1 -- us2k111Minor allele frequency- G:0.29NA WA CSA EA 374
    rs1914000581,2
    C--186198085(+) GTCGGA/CGTCCC 1 -- us2k10--------
    rs1424572671,2
    --186198096(+) ACTCCA/GTTGCC 1 -- us2k10--------
    rs1112906471,2
    F--186198099(+) CCGTTG/CCCAGG 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1126734281,2
    C,F--186198119(+) AGTGGC/TGCAAT 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1417289891,2
    --186198176(+) GTCTCA/GGCCTC 1 -- us2k10--------
    rs1508052621,2
    C--186198204(+) CAGGCA/GCGCGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AHSG (186330712 - 186339107 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AHSG:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508974CNV Insertion20534489
    dgv1541e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): AHSG
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AHSG
    DNA2.0 Custom Variant and Variant Library Synthesis for AHSG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 138680    OMIM disorders: --

    20/48 diseases for AHSG (see all 48):    About MalaCards
    uremia    liver cirrhosis    intrahepatic cholestasis of pregnancy    alcoholic liver cirrhosis
    fatty liver disease    intrahepatic cholestasis    aortic valve stenosis    myelofibrosis
    renal osteodystrophy    hyperphosphatemia    calcinosis    hemophagocytic lymphohistiocytosis
    cholestasis    cerebritis    endometriosis    morbid obesity
    gestational diabetes    essential thrombocythemia    acute pancreatitis    insulin resistance

    5 diseases from the University of Copenhagen DISEASES database for AHSG:
    Kidney disease     Hemophagocytic lymphohistiocytosis     Hyperphosphatemia     Diabetes mellitus
    Atherosclerosis

    AHSG for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/26 Novoseek inferred disease relationships for AHSG gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcification 52.2 21 12642050 (3), 12897203 (2), 15592877 (2), 14730507 (1) (see all 12)
    endometriosis 42.2 28 9764347 (6), 10433073 (5), 15589849 (4), 9553647 (3) (see all 7)
    response acute phase 41.8 3 12642050 (2), 11943951 (1)
    insulin sensitivity 27.6 4 16567827 (2), 12145157 (1), 16024912 (1)
    insulin resistance 26.8 7 16567827 (3), 12153747 (3), 15841498 (1)
    alcoholic cirrhosis 26.6 3 17394649 (2), 11943951 (1)
    myelofibrosis 26.1 2 1958751 (1), 1408055 (1)
    osteoporosis 20.6 5 14667137 (2), 8019205 (1), 1521779 (1)
    inflammation 18.7 12 1693992 (1), 12642050 (1), 16595698 (1), 17851232 (1) (see all 10)
    renal disease 18 1 17010978 (1)

    Genetic Association Database (GAD): AHSG
    Human Genome Epidemiology (HuGE) Navigator: AHSG (34 documents)

    Export disorders for AHSG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AHSG gene, integrated from 9 sources (see all 301):
    (articles sorted by number of sources associating them with AHSG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the gene encoding human alpha 2-HS glycoprotein (AHSG). (PubMed id 9322749)1, 2, 3, 9 Osawa M....Takeichi S. (1997)
    2. Association of alpha2-HS glycoprotein (AHSG, fetuin-A) polymorphism with AHSG and phosphate serum levels. (PubMed id 15592877)1, 4, 9 Osawa M....Umetsu K. (2005)
    3. Is fetuin-A/alpha2-Heremans-Schmid glycoprotein associated with the metabolic syndrome in patients with chronic kidney disease? (PubMed id 18337634)1, 4, 9 Axelsson J....Stenvinkel P. (2008)
    4. AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects. (PubMed id 18316360)1, 4, 9 Andersen G....Pedersen O. (2008)
    5. AHSG gene variant is associated with leanness among Swedish men. (PubMed id 15806395)1, 4, 9 Lavebratt C....Arner P. (2005)
    6. Association between human alpha 2-Heremans Schmidt glycoprotein (AHSG) polymorphism and endometriosis in Korean women. (PubMed id 15589849)1, 4, 9 Kim J.G....Moon S.Y. (2004)
    7. Association of alpha2-Heremans-Schmid glycoprotein polymorphisms with subclinical atherosclerosis. (PubMed id 17062776)1, 4, 9 Lehtinen A.B....Bowden D.W. (2007)
    8. Gene polymorphisms and serum alpha-2-Heremans-Schmid levels in Italian haemodialysis patients. (PubMed id 17851232)1, 4, 9 Cozzolino M....Brancaccio D. (2007)
    9. Genetic association of alpha2-Heremans-Schmid glycoprotein polymorphism with late-onset Alzheimer's disease in Italians. (PubMed id 16002217)1, 4, 9 Geroldi D....Emanuele E. (2005)
    10. Molecular evidence for human alpha 2-HS glycoprotein (AHSG) polymorphism. (PubMed id 9003486)1, 2, 9 Osawa M.... Takeichi S. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 197 HGNC: 349 AceView: AHSG Ensembl:ENSG00000145192 euGenes: HUgn197
    ECgene: AHSG H-InvDB: AHSG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AHSG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AHSG gene:
    Search GeneIP for patents involving AHSG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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