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AHSG Gene

protein-coding GIFtS: 63

GC03P187813

alpha-2-HS-glycoprotein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
A2HS ^¹, ²
AHS ^²
Alpha-2-Z-globulin ^³
Ba-alpha-2-glycoprotein ^³
FETUA ^¹, ², ³
Fetuin-A ^³
HSGA ^¹, ²
alpha-2-HS-glycoprotein ^²
fetuin-A ^²

External Ids
HGNC: 349¹
Entrez Gene: 197²
UniProtKB: P02765³
Ensembl: ENSG00000145192⁷

Search outside databases for aliases for AHSG gene

Previous GC identifers: GC03P183102 GC03P187587 GC03P187732 GC03P187651

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AHSG:

Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes.

The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein

encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain

development and the formation of bone tissue. The protein is commonly present in the cortical

plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore

been postulated that it participates in the development of the tissues. However, its exact

significance is still obscure. [provided by RefSeq]

UniProtKB/Swiss-Prot: FETUA_HUMAN, P02765

Function: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of

bone. Shows affinity for calcium and barium ions

Gene Wiki entry for AHSG

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AHSG gene

Entrez Gene cytogenetic band: 3q27 Ensembl cytogenetic band: 3q27.3 HGNC cytogenetic band: 3q27.3

AHSG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P187813: (about GC identifiers)

Start:	187,813,544 bp from pter
End:	187,821,801 bp from pter
Size:	8,258 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FETUA_HUMAN, P02765 (See protein sequence)

Recommended Name: Alpha-2-HS-glycoprotein precursor

Size: 367 amino acids; 39325 Da

Subunit: Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is

cleaved off. The two chains A and B are held together by a single disulfide bond

Subcellular location: Secreted

Secondary accessions: A8K9N6 O14961 O14962 Q9P152

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001613.2

ENSEMBL proteins:

ENSP00000273784

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for AHSG (Fetuin A/AHSG)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Fetuin, Alpha 2 HS Glycoprotein)
	Human Recombinant Proteins from Abnova (AHSG)

OriGene Purified Recombinant Human Protein: AHSG

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005615	extracellular space	NAS	11922920
GO:0031012	extracellular matrix	IEA	--

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Antibodies for AHSG:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for AHSG
	R&D Systems Antibodies for AHSG (Fetuin A/AHSG)
	Antibodies from Abcam (Fetuin, Alpha 2 HS Glycoprotein), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AHSG)
	Novus Biologicals Antibodies for AHSG

Assays for AHSG:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for AHSG (Fetuin A/AHSG) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P02765

ProtoNet protein and cluster: P02765

1 Blocks protein family: IPB000010 Cysteine protease inhibitor

UniProtKB/Swiss-Prot: FETUA_HUMAN, P02765

Similarity: Belongs to the fetuin family

Similarity: Contains 2 cystatin domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AHSG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AHSG)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001622

Applied Biosystems Silencer® siRNAs for AHSG

Sigma-Aldrich siRNA for AHSG

Sigma-Aldrich shRNA for AHSG

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AHSG
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001622
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001622
untagged cDNA clone in CMV expression vector: NM_001622

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001622

UniProtKB/Swiss-Prot: FETUA_HUMAN, P02765

Function: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of

bone. Shows affinity for calcium and barium ions

Genatlas biochemistry entry for AHSG:

HS-glycoprotein,alpha-2-,inhibitor of the insulin-receptor tyrosine kinase,pp63 (cystatin

superfamily)

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ahsg):

growth/size

homeostasis/metabolism

muscle

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004869	cysteine-type endopeptidase inhibitor activity	IEA	--
GO:0005515	protein binding	IPI	17474147
GO:0019210	kinase inhibitor activity	NAS	12203945
GO:0030294	receptor signaling protein tyrosine kinase inhibitor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for AHSG (Your Favorite Gene powered by Ingenuity)

Acute Phase Response Signaling

GeneDecks AHSG for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for AHSG

5/39 Interacting proteins for AHSG (ENSP00000273784³ P02765¹) via UniProtKB, MINT, and/or STRING (see all 39 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519¹	EBI-1223374, EBI-375543
BAMBI	ENSP00000364683³	STRING (score=.899)
BMP2	ENSP00000368104³	STRING (score=.899)
BMP4	ENSP00000245451³	STRING (score=.899)
BMP6	ENSP00000283147³	STRING (score=.899)

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5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	NAS	12153747
GO:0001503	ossification	IEA	--
GO:0006907	pinocytosis	NAS	12773197
GO:0006953	acute-phase response	IDA	12153747
GO:0008584	male gonad development	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AHSG
10/12 Novoseek chemical compound relationships for AHSG gene (see all 12 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
saci	71.96	3	15917161 (1), 12914574 (1), 16117875 (1)
apai	44.73	2	12914574 (1), 16117875 (1)
polyacrylamide	41.38	13	1504002 (1), 7662613 (1), 8738346 (1), 2312128 (1) (see all 8)
xbai	32.74	2	12914574 (1), 16117875 (1)
tyrosine	28.50	11	9503031 (3), 1707273 (2), 9602019 (1), 7906861 (1) (see all 8)
hydroxyapatite	27.73	1	15592877 (1)
hydroxyproline	23.20	1	1845868 (1)
calcium oxalate	22.22	1	8619372 (1)
fibrinogen	0.00	1	12687610 (1)
glucose	0.00	5	12145157 (1), 16567827 (1), 12153747 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AHSG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AHSG)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001622

Sigma-Aldrich siRNA for AHSG

Sigma-Aldrich shRNA for AHSG

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001622

REFSEQ mRNAs for AHSG gene:

NM_001622.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001622

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001622
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001622
                                 untagged cDNA clone in CMV expression vector: NM_001622

Additional cDNA sequence:

AK292751.1 AK298447.1 AK303754.1 AK312969.1 BC048198.1 BC052590.1 CR590483.1 CR590880.1

CR590983.1 CR591986.1 CR592598.1 CR592800.1 CR593230.1 CR594465.1 CR595632.1 CR596937.1

CR597357.1 CR597818.1 CR597877.1 CR598024.1 CR598201.1 CR599688.1 CR599704.1 CR599822.1

CR600033.1 CR600361.1 CR600789.1 CR601258.1 CR601261.1 CR601414.1 CR601433.1 CR601952.1

CR602438.1 CR603843.1 CR603950.1 CR605962.1 CR605966.1 CR606330.1 CR606631.1 CR607355.1

CR607382.1 CR607622.1 CR608868.1 CR609106.1 CR609433.1 CR609460.1 CR611718.1 CR612049.1

CR612128.1 CR613180.1 CR613958.1 CR614059.1 CR614997.1 CR615277.1 CR615840.1 CR616075.1

CR616438.1 CR616558.1 CR616627.1 CR616960.1 CR619431.1 CR619823.1 CR622619.1 CR622687.1

CR622904.1 CR623461.1 CR626686.1 CR626745.1 D67012.1 M16961.1

22 DOTS entries:

DT.419026 DT.100887723 DT.100887750 DT.100770454 DT.100887731 DT.100887742 DT.120890675 DT.406927

DT.437637 DT.100887741 DT.100887730 DT.120890669 DT.120890674 DT.120890691 DT.91753824 DT.100032673

DT.100887722 DT.100887762 DT.120890689 DT.91768644 DT.91768648 DT.120890657

24/533 AceView cDNA sequences (see all 533 ):

BX426937 BX448688 CB146663 AV659884 CR616960 BQ645013 AV649810 AU121295

CR622619 CB141738 BX400085 CB137662 CB138220 CR619431 CR622904 BX406492

CR594465 CR591986 CR611718 CR612128 CR602438 CB139128 CR626686 AL532539

highest scoring ESTs for AHSG:

M16961 AA009574 AA343339 AA778042 AI110579 AI114537 AI114795 AI133354 AI133390 AI133680

Unigene Cluster for AHSG:

Alpha-2-HS-glycoprotein

Hs.324746 [show with all ESTs]

Unigene Representative Sequence: NM_001622

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for AHSG (see all 6 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	·	7c
SP1:											-
SP2:											-
SP3:											-
SP4:											-
SP5:

About this scheme

ECgene alternative splicing isoforms for AHSG

1 Ensembl transcript including schematic representation:

ENST00000273784

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AHSG expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AHSG

¹ / ² / ³

5 probe-sets matching AHSG gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36621_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M16961	1.00	1.00	1.00	1
210929_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
204551_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001622	0.60	1.00	0.82	1
210929_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204551_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks AHSG for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATTGTGTTCT

SOURCE GeneReport for Unigene cluster: Hs.324746
Expression variation in blood from EXPOLDB for AHSG
UniProtKB/Swiss-Prot: FETUA_HUMAN, P02765
Tissue specificity: Synthesized in liver and selectively concentrated in bone matrix. Secrete din
plasma. It is also found in dentin in much higher quantities than other plasma proteins

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AHSG gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AHSG¹	--	alpha-2-HS-glycoprotein	77.69(n) 69.97(a)	607538 XM_855200.1 XP_860293.1
chimpanzee (Pan troglodytes)	AHSG¹	--	alpha-2-HS-glycoprotein	98.91(n) 97.55(a)	460912 NM_001009098.1 NP_001009098.1
cow (Bos taurus)	AHSG¹	--	alpha-2-HS-glycoprotein	75.51(n) 65.36(a)	280988 NM_173984.2 NP_776409.1
rat (Rattus norvegicus)	Ahsg¹	--	alpha-2-HS-glycoprotein	73.14(n) 63.43(a)	25373 NM_012898.4 NP_037030.1
mouse (Mus musculus)	Ahsg^{1, 5}	16 (15.00 cM)⁵	alpha-2-HS-glycoprotein^{1, 5}	72.56(n)¹ 62.61(a)¹	11625¹ NM_013465.1¹ NP_038493.1¹ AA545091⁵ AF007900⁵ (see all 15)

About this table Species with no ortholog for AHSG

ENSEMBL Gene Tree for AHSG

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AHSG gene

FETUB²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: FETUA_HUMAN, P02765

Polymorphism: There are two common alleles, AHSG*1 and AHSG*2. AHSG*1 has Thr-248/Thr-256; AHSG*2

has Met-248/Ser-256

10/63 NCBI SNPs in AHSG are shown (see all 63 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 58)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2248690^1,2	A,C,F,H	187812782(+)	`TCAAAA/TGAGTC`	1	--	ng5¹ tfbs³		12		EA EU WA NA	2418
	rs4917^1,2	A,C,F,H	187820407(+)	`CTGCAC/TGGTGT`	1	M/T	mis¹		14		MN EA NA EU WA	1312
	rs6795506^1,2	C,F,H	187812661(+)	`TGGCCA/GGAAAG`	1	--	ng5¹		4		EU EA WA	412
	rs2077119^1,2	C,F,H	187813156(+)	`GACATG/TGGAGA`	1	--	ng5¹		12		NA EA EU WA	2306
	rs4918^1,2	C,F,H	187821076(+)	`CGTGAC/GCTCAC`	1	S/T	mis¹		23		NA EA MN EU WA	1878
	rs7633550^1,2	C,H	187817684(+)	`AGGACG/TTGCGC`	1	V/L	mis¹ ese³		5		EU EA WA NA	480
--	rs11712978^1,2	A,C	187822037(+)	`acccaC/Ggctgg`	1	--	ng3¹		0	--	--	--	--
	rs2681427^1,2	A,C	187821888(+)	`CAAAAC/TCAAAG`	1	--	ng3¹		0	--	--	--	--
--	rs2593814^1,2	A	187811936(-)	`aggccG/Tagaga`	1	--	ng5¹		0	--	--	--	--
--	rs4831^1,2	A,C,F,H	187813663(+)	`CAGCTC/GTGGGG`	1	L/L	syn¹		14		MN EU EA WA NA	1335

About this table

HapMap Linkage Disequilibrium images for AHSG (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 138680

10/26 Novoseek disease relationships for AHSG gene (see all 26 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcification	52.09	21	12642050 (3), 12897203 (2), 15592877 (2), 14730507 (1) (see all 12)
endometriosis	43.81	28	9764347 (6), 10433073 (5), 15589849 (4), 9553647 (3) (see all 7)
response acute phase	42.77	3	12642050 (2), 11943951 (1)
insulin sensitivity	29.57	4	16567827 (2), 12145157 (1), 16024912 (1)
alcoholic cirrhosis	27.80	3	17394649 (2), 11943951 (1)
myelofibrosis	27.58	2	1958751 (1), 1408055 (1)
insulin resistance	25.26	7	16567827 (3), 12153747 (3), 15841498 (1)
osteoporosis	22.30	5	14667137 (2), 8019205 (1), 1521779 (1)
renal disease	20.21	1	17010978 (1)
fatty liver	19.61	4	16567827 (2), 18335040 (1), 1408055 (1)

About this table

Human Gene Mutation Database: AHSG
Genetic Association Database: AHSG
Human Genome Epidemiology Navigator: AHSG (19 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/202 PubMed articles for AHSG gene (see all 202 ):

Structure of the gene encoding human alpha 2-HS glycoprotein (AHSG). (PubMed id 9322749)^{1, 2, 3, 4} Osawa M....Takeichi S. (1997)
Association of alpha2-HS glycoprotein (AHSG, fetuin-A) polymorphism with AHSG and phosphate serum levels. (PubMed id 15592877)^{1, 3, 6} Osawa M....Umetsu K. (2005)
AHSG gene variant is associated with leanness among Swedish men. (PubMed id 15806395)^{1, 3, 6} Lavebratt C....Arner P. (2005)
Association between human alpha 2-Heremans Schmidt glycoprotein (AHSG) polymorphism and endometriosis in Korean women. (PubMed id 15589849)^{1, 3, 6} Kim J.G....Moon S.Y. (2004)
Genetic association of alpha2-Heremans-Schmid glycoprotein polymorphism with late-onset Alzheimer's disease in Italians. (PubMed id 16002217)^{1, 3, 6} Geroldi D....Emanuele E. (2005)
Molecular evidence for human alpha 2-HS glycoprotein (AHSG) polymorphism. (PubMed id 9003486)^{1, 3, 4} Osawa M.... Takeichi S. (1997)
Polymorphism of the AHSG gene is associated with increased adipocyte beta2-adrenoceptor function. (PubMed id 16024912)^{1, 3, 6} Lavebratt C....Hoffstedt J. (2005)
No evidence for linkage and/or association of human alpha2-HS glycoprotein gene with bone mineral density variation in Chinese nuclear families. (PubMed id 14667137)^{1, 3, 6} Liu X.H....Deng H.W. (2003)
Bone mineral density and five prominent candidate genes in Chinese men: associations, interaction effects and their implications. (PubMed id 15917161)^{1, 3, 6} Lei S.F....Deng H.W. (2005)
alpha2-Heremans-Schmid glycoprotein gene polymorphisms are associated with adipocyte insulin action. (PubMed id 15599699)^{1, 3, 6} Dahlman I....Arner P. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 197	HGNC: 349	AceView: AHSG	Ensembl:ENSG00000145192	euGenes: HUgn197
ECgene: AHSG	H-InvDB: AHSG

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for AHSG
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AHSG:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AHSG-related products

	Millipore Custom Antibody & Bulk Services
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	Recombinant Proteins (Fetuin, Alpha 2 HS Glycoprotein)
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	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Antibodies for AHSG

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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AHSG Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for AHSG

Summaries
for AHSG

Genomic Location
for AHSG

Proteins
for AHSG

Protein Domains/
Families
for AHSG

Gene Function
for AHSG

Pathways & Interactions
for AHSG

Drugs & Compounds
for AHSG

Transcripts
for AHSG

Expression
for AHSG

Orthologs
for AHSG

Paralogs
for AHSG

SNPs/Variants
for AHSG

Disorders & Mutations
for AHSG

Medical News
for AHSG

Publications
for AHSG

Search for AHSG

Genome Databases showing AHSG

Other Databases showing AHSG

Specialized Databases showing AHSG

Licensable Technologies
for AHSG

Services
for AHSG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AHSG Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor AHSG

Summariesfor AHSG

Genomic Locationfor AHSG

Proteinsfor AHSG

Protein Domains/Familiesfor AHSG

Gene Functionfor AHSG

Pathways & Interactionsfor AHSG

Drugs & Compoundsfor AHSG

Transcriptsfor AHSG

Expression for AHSG

Orthologsfor AHSG

Paralogsfor AHSG

SNPs/Variantsfor AHSG

Disorders & Mutationsfor AHSG

Medical Newsfor AHSG

Publicationsfor AHSG

Search for AHSG

Genome Databases showing AHSG

Other Databases showing AHSG

Specialized Databases showing AHSG

Licensable Technologiesfor AHSG

Servicesfor AHSG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AHSG

Summaries
for AHSG

Genomic Location
for AHSG

Proteins
for AHSG

Protein Domains/
Families
for AHSG

Gene Function
for AHSG

Pathways & Interactions
for AHSG

Drugs & Compounds
for AHSG

Transcripts
for AHSG

Expression
for AHSG

Orthologs
for AHSG

Paralogs
for AHSG

SNPs/Variants
for AHSG

Disorders & Mutations
for AHSG

Medical News
for AHSG

Publications
for AHSG

Licensable Technologies
for AHSG

Services
for AHSG