Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



AHSG Gene

protein-coding   GIFtS: 62
GCID: GC03P186330

Alpha-2-HS-Glycoprotein

  See AHSG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
alpha-2-HS-glycoprotein1 2     ba-alpha-2-glycoprotein2
FETUA2 3     fetuin-A2
A2HS2     Alpha-2-Z-globulin3
AHS2     Ba-alpha-2-glycoprotein3
HSGA2     Fetuin-A3
alpha-2-Z-globulin2     

External Ids:    HGNC: 3491   Entrez Gene: 1972   Ensembl: ENSG000001451927   OMIM: 1386805   UniProtKB: P027653   

Export aliases for AHSG gene to outside databases

Previous GC identifers: GC03P183102 GC03P187587 GC03P187732 GC03P187651 GC03P187813 GC03P183739


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for AHSG Gene:
Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG
molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA.
It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The
protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic
matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its
exact significance is still obscure. (provided by RefSeq, Jul 2008)

GeneCards Summary for AHSG Gene:
AHSG (alpha-2-HS-glycoprotein) is a protein-coding gene. Diseases associated with AHSG include uremia, and alcoholic liver cirrhosis. GO annotations related to this gene include kinase inhibitor activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is FETUB.

UniProtKB/Swiss-Prot: FETUA_HUMAN, P02765
Function: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows
affinity for calcium and barium ions

Gene Wiki entry for AHSG ('2-HS-glycoprotein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the AHSG gene promoter:
         AML1a   NF-kappaB   E4BP4   GATA-1   FOXL1   C/EBPalpha   SRY   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAHSG promoter sequence
   Search Chromatin IP Primers for AHSG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AHSG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q27.3

AHSG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AHSG gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P186330:  view genomic region     (about GC identifiers)

Start:
186,330,712 bp from pter      End:
186,339,107 bp from pter
Size:
8,396 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FETUA_HUMAN, P02765 (See protein sequence)
Recommended Name: Alpha-2-HS-glycoprotein precursor  
Size: 367 amino acids; 39325 Da
Subunit: Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two
chains A and B are held together by a single disulfide bond
Secondary accessions: A8K9N6 B2R7G1 O14961 O14962 Q9P152

Explore the universe of human proteins at neXtProt for AHSG: NX_P02765

Explore proteomics data for AHSG at MOPED

Post-translational modifications: 

  • Phosphorylation sites are present in the extracellular medium1
  • O- and N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan at Asn-156: Hex5HexNAc4;
    N-glycan heterogeneity at Asn-176: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor)1
  • Glycosylation2 at Asn156, Asn176, Thr256, Thr270, Ser346
  • Modification sites at PhosphoSitePlus

  • See AHSG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001613.2  
    ENSEMBL proteins: 
     ENSP00000393887   ENSP00000273784  

    AHSG Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for AHSG (Fetuin A/AHSG)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for AHSG
    OriGene Protein Over-expression Lysate for AHSG
    OriGene MassSpec for AHSG
    OriGene Custom Protein Services for AHSG
    GenScript Custom Purified and Recombinant Proteins Services for AHSG
    Novus Biologicals AHSG Proteins
    Novus Biologicals AHSG Lysates
    Sino Biological Recombinant Protein for AHSG
    Sino Biological Cell Lysate for AHSG
    ProSpec Recombinant Protein for AHSG
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for AHSG 

    AHSG Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for AHSG (Fetuin A/AHSG)
    Cell Signaling Technology (CST) Antibodies for AHSG  (FETUA)
    OriGene Antibodies for AHSG
    OriGene Custom Antibody Services for AHSG
    Novus Biologicals AHSG Antibodies
    Abcam antibodies for AHSG (P02765, Q9UGM5)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for AHSG
    LSBio Antibodies in human, mouse, rat for AHSG

    AHSG Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AHSG
    R&D Systems ELISAs for AHSG (Fetuin A/AHSG)         (see all)
    GenScript Custom Assay Services for AHSG
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for AHSG 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR001363 Prot_inh_fetuin_CS
     IPR000010 Prot_inh_cystat
     IPR025760 Cystatin_Fetuin_A

    Graphical View of Domain Structure for InterPro Entry P02765

    ProtoNet protein and cluster: P02765

    1 Blocks protein domain: IPB000010 Cysteine protease inhibitor

    UniProtKB/Swiss-Prot: FETUA_HUMAN, P02765
    Similarity: Belongs to the fetuin family
    Similarity: Contains 2 cystatin fetuin-A-type domains


    Find genes that share domains with AHSG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FETUA_HUMAN, P02765
    Function: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows
    affinity for calcium and barium ions

         Genatlas biochemistry entry for AHSG:
    HS-glycoprotein,alpha-2-,inhibitor of the insulin-receptor tyrosine kinase,pp63 (cystatin superfamily)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004869cysteine-type endopeptidase inhibitor activity IEA--
    GO:0019210kinase inhibitor activity NAS12203945
         
    Find genes that share ontologies with AHSG           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ahsg):
     growth/size/body  homeostasis/metabolism  muscle 

    Find genes that share phenotypes with AHSG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ahsgtm1Mbl for AHSG

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AHSG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AHSG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AHSG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AHSG

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat AHSG using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate AHSG:
    hsa-miR-1248 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidAHSG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AHSG
    Predesigned siRNA for gene silencing in human, mouse, rat AHSG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AHSG

    Clone
    Products:
         
    OriGene clones in human, mouse for AHSG (see all 7)
    OriGene ORF clones in mouse, rat for AHSG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AHSG (NM_001622)
    Sino Biological Human cDNA Clone for AHSG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AHSG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHSG

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AHSG
    Browse ESI BIO Cell Lines and PureStem Progenitors for AHSG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHSG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FETUA_HUMAN, P02765: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    cytoskeleton1
    lysosome1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space NAS11922920
    GO:0070062extracellular vesicular exosome IDA19056867
    GO:0072562blood microparticle IDA--

    Find genes that share ontologies with AHSG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for AHSG About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by BMP
    BMP receptor signaling0.31
    2Glucose / Energy Metabolism
    Glucose / Energy Metabolism


    Find genes that share SuperPaths with AHSG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for AHSG
        Glucose / Energy Metabolism

    1 BioSystems Pathway for AHSG
        BMP receptor signaling



        Pathway & Disease-focused RT2 Profiler PCR Arrays including AHSG: 
              Osteogenesis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AHSG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for AHSG (P027651, 2, 3 ENSP000003938874) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005191, 2, 3, ENSP000003614234EBI-1223374,EBI-375543 MINT-8110347 I2D: score=3 STRING: ENSP00000361423
    DCNP075853, ENSP000000527544I2D: score=2 STRING: ENSP00000052754
    NR3C1P041503, ENSP000002315094I2D: score=1 STRING: ENSP00000231509
    FBXO2Q9UK223, ENSP000003462404I2D: score=2 STRING: ENSP00000346240
    INSRP062133, ENSP000003038304I2D: score=2 STRING: ENSP00000303830
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development NAS12153747
    GO:0001503ossification IEA--
    GO:0006907pinocytosis NAS12773197
    GO:0006953acute-phase response IDA12153747
    GO:0030500regulation of bone mineralization NAS3474608

    Find genes that share ontologies with AHSG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AHSG (FETUA)

    1 HMDB Compound for AHSG    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for AHSG gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    saci 71.6 3 15917161 (1), 12914574 (1), 16117875 (1)
    kininogen 58.1 9 19273244 (1), 2107324 (1), 7736783 (1)
    apai 43.2 2 12914574 (1), 16117875 (1)
    polyacrylamide 40.4 13 1504002 (1), 7662613 (1), 8738346 (1), 2312128 (1) (see all 8)
    xbai 31.6 2 12914574 (1), 16117875 (1)
    tyrosine 29.2 12 9503031 (3), 1707273 (2), 9602019 (1), 7906861 (1) (see all 9)
    cysteine 28.4 4 1689725 (1), 1372866 (1), 17010978 (1), 8866020 (1)
    hydroxyapatite 26 1 15592877 (1)
    hydroxyproline 21.9 1 1845868 (1)
    calcium oxalate 20.9 1 8619372 (1)



    Find genes that share compounds with AHSG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for AHSG gene: 
    NM_001622.2  

    Unigene Cluster for AHSG:

    Alpha-2-HS-glycoprotein
    Hs.324746  [show with all ESTs]
    Unigene Representative Sequence: NM_001622
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000411641(uc003fqk.4) ENST00000273784 ENST00000478441(uc003fqj.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AHSG using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate AHSG:
    hsa-miR-1248 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidAHSG 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AHSG
    Predesigned siRNA for gene silencing in human, mouse, rat AHSG
    Clone
    Products:
         
    OriGene clones in human, mouse for AHSG (see all 7)
    OriGene ORF clones in mouse, rat for AHSG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AHSG (NM_001622)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AHSG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHSG
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AHSG
    OriGene qSTAR qPCR primer pairs in human, mouse for AHSG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AHSG
      QuantiTect SYBR Green Assays in human, mouse, rat AHSG
      QuantiFast Probe-based Assays in human, mouse, rat AHSG

    Additional mRNA sequence: 

    AK292751.1 AK298447.1 AK303754.1 AK312969.1 BC048198.1 BC052590.1 D67012.1 M16961.1 

    22 DOTS entries:

    DT.419026  DT.100887723  DT.100887750  DT.100770454  DT.100887731  DT.100887742  DT.120890675  DT.406927 
    DT.437637  DT.100887741  DT.100887730  DT.120890669  DT.120890674  DT.120890691  DT.91753824  DT.100032673 
    DT.100887722  DT.100887762  DT.120890689  DT.91768644  DT.91768648  DT.120890657 

    Selected AceView cDNA sequences (see all 533):

    CB141738 CR609106 CB154104 CR616075 CR619431 AV649818 CR615277 CB137662 
    BX400085 BQ646658 CR600033 CR597357 AL564611 CR591986 CR601261 CR601414 
    N58400 AA701498 CB138721 AV660613 BX427711 CR612128 CR603843 CR605966 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AHSG (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
    SP1:                                -                                       
    SP2:                                -                                       
    SP3:                                -                                       
    SP4:                                -                                       
    SP5:                                                                        


    ECgene alternative splicing isoforms for AHSG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    AHSG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGTGTTCT
    AHSG Expression
    About this image


    AHSG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 6 entries
             Atrioventricular Node Cells Atrioventricular Node
             Left Atrium
             Cardiomyocyte-like progenitor cells
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Long Bone
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Vascular endothelial growth factor-induced embryoid bodies
     
     Liver (Hepatobiliary System)
             Hepatocyte-like cells
    AHSG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AHSG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.324746

    UniProtKB/Swiss-Prot: FETUA_HUMAN, P02765
    Tissue specificity: Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is
    also found in dentin in much higher quantities than other plasma proteins

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AHSG: 
              Osteogenesis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AHSG
    OriGene qSTAR qPCR primer pairs in human, mouse for AHSG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AHSG
    QuantiTect SYBR Green Assays in human, mouse, rat AHSG
    QuantiFast Probe-based Assays in human, mouse, rat AHSG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHSG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for AHSG gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ahsg1 , 5 alpha-2-HS-glycoprotein1, 5 73.08(n)1
    63.27(a)1
      16 (13.74 cM)5
    116251  NM_013465.21  NP_038493.11 
     228920425 
    chicken
    (Gallus gallus)
    Aves AHSG1 alpha-2-HS-glycoprotein 52.22(n)
    44(a)
      424956  XM_422764.4  XP_422764.1 
    lizard
    (Anolis carolinensis)
    Reptilia AHSG6
    alpha-2-HS-glycoprotein
    36(a)
    1 ↔ 1
    GL343321.1(218916-262352)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ahsg1 alpha-2-HS-glycoprotein 50.94(n)
    42.86(a)
      496731  NM_001011278.1  NP_001011278.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ahsg1 alpha-2-HS-glycoprotein 47.66(n)
    35.96(a)
      569558  NM_212622.1  NP_997787.1 


    ENSEMBL Gene Tree for AHSG (if available)
    TreeFam Gene Tree for AHSG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for AHSG gene
    FETUB2  

    Find genes that share paralogs with AHSG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    FETUA_HUMAN, P02765: There are two common alleles, AHSG*1 and AHSG*2. AHSG*1 has Thr-248/Thr-256; AHSG*2 has
    Met-248/Ser-256


    Selected SNPs for AHSG (see all 329)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs49171,2,,4
    C,F,A,Hother1186206756(+) CTGCAC/TGGTGT 2 T M mis138Minor allele frequency- T:0.30MN EA NA NS WA CSA EU 8937
    rs49181,2,,4
    C,F,Hother1186207425(+) CGTGAC/GCTCAC 2 T S mis134Minor allele frequency- G:0.34NA EA MN NS WA CSA EU 7572
    rs350942351,2
    C,F--186197995(+) CCAGGG/TCTTAT 1 -- us2k111Minor allele frequency- T:0.23NA WA CSA EA 373
    rs26814281,2
    C,F--186198036(+) CAGGTT/GTGTGC 1 -- us2k111Minor allele frequency- G:0.29NA WA CSA EA 374
    rs1914000581,2
    C--186198085(+) GTCGGA/CGTCCC 1 -- us2k10--------
    rs1424572671,2
    --186198096(+) ACTCCA/GTTGCC 1 -- us2k10--------
    rs1112906471,2
    F--186198099(+) CCGTTG/CCCAGG 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1126734281,2
    C,F--186198119(+) AGTGGC/TGCAAT 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1417289891,2
    --186198176(+) GTCTCA/GGCCTC 1 -- us2k10--------
    rs1508052621,2
    C--186198204(+) CAGGCA/GCGCGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AHSG (186330712 - 186339107 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AHSG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508974CNV Insertion20534489
    dgv1541e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): AHSG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AHSG
    DNA2.0 Custom Variant and Variant Library Synthesis for AHSG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 138680    OMIM disorders: --

    6 diseases for AHSG:    
    About MalaCards
    uremia    alcoholic liver cirrhosis    liver cirrhosis    intrahepatic cholestasis of pregnancy
    aortic valve stenosis    insulin resistance

    5 diseases from the University of Copenhagen DISEASES database for AHSG:
    Kidney disease     Hemophagocytic lymphohistiocytosis     Hyperphosphatemia     Diabetes mellitus
    Atherosclerosis

    Find genes that share disorders with AHSG           About GenesLikeMe

    Selected Novoseek inferred disease relationships for AHSG gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcification 52.2 21 12642050 (3), 12897203 (2), 15592877 (2), 14730507 (1) (see all 12)
    endometriosis 42.2 28 9764347 (6), 10433073 (5), 15589849 (4), 9553647 (3) (see all 7)
    response acute phase 41.8 3 12642050 (2), 11943951 (1)
    insulin sensitivity 27.6 4 16567827 (2), 12145157 (1), 16024912 (1)
    insulin resistance 26.8 7 16567827 (3), 12153747 (3), 15841498 (1)
    alcoholic cirrhosis 26.6 3 17394649 (2), 11943951 (1)
    myelofibrosis 26.1 2 1958751 (1), 1408055 (1)
    osteoporosis 20.6 5 14667137 (2), 8019205 (1), 1521779 (1)
    inflammation 18.7 12 1693992 (1), 12642050 (1), 16595698 (1), 17851232 (1) (see all 10)
    renal disease 18 1 17010978 (1)

    Genetic Association Database (GAD): AHSG
    Human Genome Epidemiology (HuGE) Navigator: AHSG (34 documents)

    Export disorders for AHSG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for AHSG gene, integrated from 10 sources (see all 316):
    (articles sorted by number of sources associating them with AHSG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the gene encoding human alpha 2-HS glycoprotein (AHSG). (PubMed id 9322749)1, 2, 3, 9 Osawa M....Takeichi S. (Gene 1997)
    2. Association of alpha2-HS glycoprotein (AHSG, fetuin-A) polymorphism with AHSG and phosphate serum levels. (PubMed id 15592877)1, 4, 9 Osawa M....Umetsu K. (Hum. Genet. 2005)
    3. Is fetuin-A/alpha2-Heremans-Schmid glycoprotein associated with the metabolic syndrome in patients with chronic kidney disease? (PubMed id 18337634)1, 4, 9 Axelsson J....Stenvinkel P. (Am. J. Nephrol. 2008)
    4. AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects. (PubMed id 18316360)1, 4, 9 Andersen G....Pedersen O. (Diabetes 2008)
    5. AHSG gene variant is associated with leanness among Swedish men. (PubMed id 15806395)1, 4, 9 Lavebratt C....Arner P. (Hum. Genet. 2005)
    6. Association between human alpha 2-Heremans Schmidt glycoprotein (AHSG) polymorphism and endometriosis in Korean women. (PubMed id 15589849)1, 4, 9 Kim J.G....Moon S.Y. (Fertil. Steril. 2004)
    7. Association of alpha2-Heremans-Schmid glycoprotein polymorphisms with subclinical atherosclerosis. (PubMed id 17062776)1, 4, 9 Lehtinen A.B....Bowden D.W. (J. Clin. Endocrinol. Metab. 2007)
    8. Gene polymorphisms and serum alpha-2-Heremans-Schmid levels in Italian haemodialysis patients. (PubMed id 17851232)1, 4, 9 Cozzolino M....Brancaccio D. (Am. J. Nephrol. 2007)
    9. Genetic association of alpha2-Heremans-Schmid glycoprotein polymorphism with late-onset Alzheimer's disease in Italians. (PubMed id 16002217)1, 4, 9 Geroldi D....Emanuele E. (Neurosci. Lett. 2005)
    10. Molecular evidence for human alpha 2-HS glycoprotein (AHSG) polymorphism. (PubMed id 9003486)1, 2, 9 Osawa M.... Takeichi S. (Hum. Genet. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 197 HGNC: 349 AceView: AHSG Ensembl:ENSG00000145192 euGenes: HUgn197
    ECgene: AHSG H-InvDB: AHSG

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for AHSG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AHSG gene:
    Search GeneIP for patents involving AHSG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for AHSG (Fetuin A/AHSG)   Browse Cell Culture Products  
     ELISAs for AHSG (Fetuin A/AHSG)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Luminex Assays for AHSG (Fetuin A/AHSG)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for AHSG (Fetuin A/AHSG)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for AHSG (Fetuin A/AHSG)  
     OriGene Antibodies for AHSG   OriGene RNAi products in human, mouse, rat for AHSG  
     OriGene qPCR primer pairs and template standards for AHSG   OriGene Protein Over-expression Lysate for AHSG  
     OriGene MassSpec something-or-other for AHSG   OriGene clones in human, mouse for AHSG  
     OriGene qSTAR qPCR primer pairs in human, mouse for AHSG   OriGene Purified Protein for AHSG  
     OriGene ORF clones in mouse, rat for AHSG   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AHSG   OriGene Custom Protein Services for AHSG  

     
     
     Block miRNA regulation of human, mouse, rat AHSG using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AHSG
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AHSG Predesigned siRNA for gene silencing in human, mouse, rat AHSG
     QuantiFast Probe-based Assays in human, mouse, rat AHSG QuantiTect SYBR Green Assays in human, mouse, rat AHSG
     PCR Arrays including human, mouse, rat AHSG Search Chromatin IP Primers for AHSG
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AHSG  GeneGlobe Interaction Network for AHSG
     Regulatory tfbs in AHSG promoter
     GenScript Custom Purified and Recombinant Proteins Services for AHSG GenScript cDNA clones with any tag delivered in your preferred vector for AHSG
     GenScript Custom Assay Services for AHSG GenScript Custom overexpressing Cell Line Services for AHSG
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for AHSG  (FETUA)

     Search Tocris compounds for AHSG (FETUA)
     Proteins for AHSG
     Cell Lysates for AHSG
     cDNA Clones for AHSG
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     AHSG antibodies
     AHSG proteins
     AHSG lysates
     Antibodies for AHSG
     See all of Abcam's Antibodies, Kits and Proteins for AHSG
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for AHSG
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for AHSG
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHSG
     SwitchGear 3'UTR luciferase reporter plasmids for AHSG
     SwitchGear Promoter luciferase reporter plasmids for AHSG
     ThermoFisher Antibody for AHSG
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHSG
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AHSG
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AHSG
     LSBio Antibodies in human, mouse, rat for AHSG
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for AHSG
      Search eBioscience for proteins for AHSG
      Search eBioscience for elisas for AHSG
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AHSG gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4