AHSG Gene

Aliases
for AHSG gene

Previous GC identifers: GC03P183102 GC03P187587 GC03P187732 GC03P187651 GC03P187813 GC03P183739

Summaries
for AHSG gene

Genomic Views
for AHSG gene

RefSeq DNA sequence:

NC_000003.11  NC_018914.1  NT_005612.16  

SwitchGear Promoter luciferase reporter plasmid: AHSG promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AHSG

AHSG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P186330:  view genomic region     (about GC identifiers)

Proteins
for AHSG gene

Explore the universe of human proteins at neXtProt for AHSG: NX_P02765

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for AHSG (Fetuin A/AHSG)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: AHSG OriGene Protein Over-expression Lysate: AHSG OriGene Custom Protein Services for AHSG
	GenScript Custom Purified and Recombinant Proteins Services for AHSG
	Novus Biologicals AHSG Protein Novus Biologicals AHSG Lysates
	Sino Biological Recombinant Protein for AHSG
	ProSpec Recombinant Protein for AHSG
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for AHSG (Fetuin A/AHSG)
	Cell Signaling Technology (CST) Antibodies for AHSG  (FETUA)
	OriGene Antibodies: AHSG OriGene Custom Antibody Services for AHSG
	GenScript Custom Superior Antibodies Services for AHSG
	Novus Biologicals AHSG Antibodies
	Abcam antibodies for AHSG
	Browse Antibodies at Uscn
	ThermoFisher Antibody for AHSG

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for AHSG (Fetuin A/AHSG)         (see all)
	GenScript Custom Assay Services for AHSG
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

Protein Domains /
Families
for AHSG gene

ProtoNet protein and cluster: P02765

Function
for AHSG gene

miRNA Products:		OriGene 3'-UTR Clone: AHSG Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AHSG
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate AHSG:
		hsa-miR-1248 hsa-miR-335
		SwitchGear 3'UTR luciferase reporter plasmid: AHSG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AHSG (see all 7) OriGene shRNA RFP: AHSG OriGene siRNA: AHSG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AHSG

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for AHSG

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AHSG (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AHSG OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: AHSG (NM_001622)
		Sino Biological Human cDNA Clone for AHSG
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for AHSG
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHSG

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for AHSG
		Search LifeMap BioReagents cell lines for AHSG

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHSG

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Ahsg)

Pathways & Interactions
for AHSG gene

	Super-pathway	contained gene-specific pathways
1	Glucose / Energy Metabolism	Glucose / Energy Metabolism 1.00
2	Signaling by BMP	BMP receptor signaling 0.31

1 Cell Signaling Technology (CST) Pathway for AHSG

Glucose / Energy Metabolism

1 BioSystems Pathway for AHSG

BMP receptor signaling

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

Drugs & Compounds
for AHSG gene

Transcripts
for AHSG gene

Expression
for AHSG gene

AHSG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTGTGTTCT

9 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	HeartAtrioventricular NodeAtrioventricular Node Cells			Myocardium
	LimbZeugopodMesenchymal Condensate Cells			Bone, Cartilage
	BoneZeugopod Long Bone			Bone
	HeartLeft Atrium			Heart
	HeartLeft Ventricle			Heart
	HeartRight Atrium			Heart
	HeartRight Ventricle			Heart
	LimbAutopod			Limb
	LimbZeugopod			Limb
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 5 LifeMap Cells
	Name			Category
	Embryoid bodies (Two-step protocol fo...)
	Cardiomyocyte-like progenitor cells (Derivation of cardio...)
	Beating cell clusters (Spontaneous differen...)
	Mesendoderm (Derivation and sorti...)
	Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AHSG Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AHSG
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AHSG
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AHSG

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHSG

Orthologs
for AHSG gene

Paralogs
for AHSG gene

Paralogs for AHSG gene

FETUB²  

AHSG for paralogs           About GeneDecksing

Genomic Variants
for AHSG gene

10/252 NCBI SNPs in AHSG are shown (see all 252)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs49181,2	C,F,H,	other	186338382(+)	CGTGAC/GCTCAC	2	T S	mis1		34		NA EA MN NS WA CSA EU	7572
rs49171,2	C,F,A,H,	other	199111280(+)	CTGCAC/TGGTGT	2	T M	mis1		38		MN EA NA NS WA CSA EU	8937
rs1112906471,2		--	183738122(+)	CCGTTG/CCCAGG	1	--	us2k1		1		CSA	2
rs1126734281,2	C,	--	183738142(+)	AGTGGC/TGCAAT	1	--	us2k1		1		NA	2
rs622945841,2		--	183738398(+)	AAAGAT/CTATAT	1	--	us2k1		2		NA	122
rs1124125671,2		--	183738546(+)	TCATGG/TTCCCC	1	--	us2k1		1		CSA	2
rs2022474641,2	C	--	183738777(-)	AAAAAA/CTGGTT	1	--	us2k1		0	--	--	--	--
rs738879761,2	C,	--	183738894(+)	TCAGAC/GTAAAC	1	--	us2k1		2		WA	120
rs67955061,2	C,F,H,	--	183739034(+)	TGGCCA/GGAAAG	1	--	us2k1		7		EA NS NA WA	418
rs1130975341,2	C,	--	183739272(+)	GTGAGG/TTCTGG	1	--	us2k1		3		NA WA	240

HapMap Linkage Disequilibrium report for AHSG (186330712 - 186339107 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for AHSG
     1 CNV: 3467
Human Gene Mutation Database (HGMD): AHSG

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AHSG

DNA2.0 Custom Variant and Variant Library Synthesis for AHSG

Disorders / Diseases
for AHSG gene

20/53 diseases for AHSG

10/26 Novoseek disease relationships for AHSG gene (see all 26)    About this table

Publications
for AHSG gene

PubMed articles for AHSG gene, integrated from 9 sources (see all 289): (articles sorted by number of sources associating them with AHSG)

Utopia: connect your pdf to the dynamic world of online information

1. Structure of the gene encoding human alpha 2-HS glycoprotein (AHSG). (PubMed id 9322749)^{1, 2, 3, 9} Osawa M....Takeichi S. (1997)
2. Association of alpha2-HS glycoprotein (AHSG, fetuin-A) polymorphism with AHSG and phosphate serum levels. (PubMed id 15592877)^{1, 4, 9} Osawa M....Umetsu K. (2005)
3. AHSG gene variant is associated with leanness among Swedish men. (PubMed id 15806395)^{1, 4, 9} Lavebratt C....Arner P. (2005)
4. Association between human alpha 2-Heremans Schmidt glycoprotein (AHSG) polymorphism and endometriosis in Korean women. (PubMed id 15589849)^{1, 4, 9} Kim J.G....Moon S.Y. (2004)
5. Genetic association of alpha2-Heremans-Schmid glycoprotein polymorphism with late-onset Alzheimer's disease in Italians. (PubMed id 16002217)^{1, 4, 9} Geroldi D....Emanuele E. (2005)
6. Molecular evidence for human alpha 2-HS glycoprotein (AHSG) polymorphism. (PubMed id 9003486)^{1, 2, 9} Osawa M.... Takeichi S. (1997)
7. Polymorphism of the AHSG gene is associated with increased adipocyte beta2-adrenoceptor function. (PubMed id 16024912)^{1, 4, 9} Lavebratt C....Hoffstedt J. (2005)
8. No evidence for linkage and/or association of human alpha2-HS glycoprotein gene with bone mineral density variation in Chinese nuclear families. (PubMed id 14667137)^{1, 4, 9} Liu X.H....Deng H.W. (2003)
9. Bone mineral density and five prominent candidate genes in Chinese men: associations, interaction effects and their implications. (PubMed id 15917161)^{1, 4, 9} Lei S.F....Deng H.W. (2005)
10. alpha2-Heremans-Schmid glycoprotein gene polymorphisms are associated with adipocyte insulin action. (PubMed id 15599699)^{1, 4, 9} Dahlman I....Arner P. (2004)

External Searches for AHSG gene

Genome Databases showing AHSG gene

Other Databases showing AHSG gene

Specialized Databases showing AHSG gene

Products
for AHSG gene