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Aliases for AHSA2 Gene

Aliases for AHSA2 Gene

  • AHA1, Activator Of Heat Shock 90kDa Protein ATPase Homolog 2 (Yeast) 2 3 5
  • Hch1 3

External Ids for AHSA2 Gene

Previous GeneCards Identifiers for AHSA2 Gene

  • GC02P061591
  • GC02P061362
  • GC02P061379
  • GC02P061316
  • GC02P061258
  • GC02P061404
  • GC02P061145

Summaries for AHSA2 Gene

GeneCards Summary for AHSA2 Gene

AHSA2 (AHA1, Activator Of Heat Shock 90kDa Protein ATPase Homolog 2 (Yeast)) is a Protein Coding gene. GO annotations related to this gene include chaperone binding and ATPase activator activity. An important paralog of this gene is AHSA1.

UniProtKB/Swiss-Prot for AHSA2 Gene

  • Co-chaperone that stimulates HSP90 ATPase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AHSA2 Gene

Genomics for AHSA2 Gene

Regulatory Elements for AHSA2 Gene

Enhancers for AHSA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AHSA2 on UCSC Golden Path with GeneCards custom track

Promoters for AHSA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AHSA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for AHSA2 Gene

Chromosome:
2
Start:
61,177,418 bp from pter
End:
61,191,203 bp from pter
Size:
13,786 bases
Orientation:
Plus strand

Genomic View for AHSA2 Gene

Genes around AHSA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AHSA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AHSA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AHSA2 Gene

Proteins for AHSA2 Gene

  • Protein details for AHSA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q719I0-AHSA2_HUMAN
    Recommended name:
    Activator of 90 kDa heat shock protein ATPase homolog 2
    Protein Accession:
    Q719I0
    Secondary Accessions:
    • B3KS51
    • D6W5E0
    • Q8NDU5

    Protein attributes for AHSA2 Gene

    Size:
    299 amino acids
    Molecular mass:
    33806 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AHSA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AHSA2 Gene

Proteomics data for AHSA2 Gene at MOPED

Post-translational modifications for AHSA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AHSA2 Gene

Domains & Families for AHSA2 Gene

Protein Domains for AHSA2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AHSA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q719I0

UniProtKB/Swiss-Prot:

AHSA2_HUMAN :
  • Belongs to the AHA1 family.
Family:
  • Belongs to the AHA1 family.
genes like me logo Genes that share domains with AHSA2: view

No data available for Gene Families for AHSA2 Gene

Function for AHSA2 Gene

Molecular function for AHSA2 Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone that stimulates HSP90 ATPase activity.

Gene Ontology (GO) - Molecular Function for AHSA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with AHSA2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AHSA2 Gene

Localization for AHSA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AHSA2 Gene COMPARTMENTS Subcellular localization image for AHSA2 gene
Compartment Confidence
cytoskeleton 2
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AHSA2 Gene

Pathways & Interactions for AHSA2 Gene

SuperPathways for AHSA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AHSA2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for AHSA2 Gene

Drugs & Compounds for AHSA2 Gene

No Compound Related Data Available

Transcripts for AHSA2 Gene

Unigene Clusters for AHSA2 Gene

AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AHSA2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7: - -
SP8: - -

Relevant External Links for AHSA2 Gene

GeneLoc Exon Structure for
AHSA2
ECgene alternative splicing isoforms for
AHSA2

Expression for AHSA2 Gene

mRNA expression in normal human tissues for AHSA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for AHSA2 Gene Hs.655602

genes like me logo Genes that share expression patterns with AHSA2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for AHSA2 Gene

Orthologs for AHSA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AHSA2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia AHSA2 35
  • 81.2 (n)
  • 73.68 (a)
chimpanzee
(Pan troglodytes)
Mammalia AHSA2 35
  • 98.77 (n)
  • 97.04 (a)
AHSA2 36
  • 43 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AHSA2 36
  • 21 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AHSA2 36
  • 24 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ahsa2 36
  • 32 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AHSA2 36
  • 24 (a)
OneToOne
chicken
(Gallus gallus)
Aves AHSA2 36
  • 19 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1416 36
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C01G10.8 36
  • 8 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AHA1 36
  • 6 (a)
ManyToMany
HCH1 36
  • 5 (a)
ManyToMany
Species with no ortholog for AHSA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for AHSA2 Gene

ENSEMBL:
Gene Tree for AHSA2 (if available)
TreeFam:
Gene Tree for AHSA2 (if available)

Paralogs for AHSA2 Gene

Paralogs for AHSA2 Gene

(1) SIMAP similar genes for AHSA2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AHSA2: view

Variants for AHSA2 Gene

Sequence variations from dbSNP and Humsavar for AHSA2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_038256 A breast cancer sample
rs746032 -- 61,177,873(+) CCTTT(C/T)CACTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs777584 -- 61,183,211(+) tctca(A/G)tagcc intron-variant
rs777585 -- 61,185,424(+) TTTTA(C/T)TGAGA intron-variant
rs1809028 -- 61,186,588(+) AATGC(A/G/T)GTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AHSA2 Gene

Variant ID Type Subtype PubMed ID
nsv874211 CNV Loss 21882294
nsv874212 CNV Gain 21882294
nsv819479 CNV Loss 19587683

Variation tolerance for AHSA2 Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AHSA2 Gene

Disorders for AHSA2 Gene

Relevant External Links for AHSA2

Genetic Association Database (GAD)
AHSA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AHSA2

No disorders were found for AHSA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AHSA2 Gene

Publications for AHSA2 Gene

  1. Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. (PMID: 12504007) Panaretou B. … Prodromou C. (Mol. Cell 2002) 2 3 4 67
  2. Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone. (PMID: 12604615) Lotz G.P. … Obermann W.M.J. (J. Biol. Chem. 2003) 3 23
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3
  5. Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois P.C. … van Heel D.A. (Nat. Genet. 2010) 3

Products for AHSA2 Gene

Sources for AHSA2 Gene

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