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Aliases for AHSA2 Gene

Aliases for AHSA2 Gene

  • AHA1, Activator Of Heat Shock 90kDa Protein ATPase Homolog 2 (Yeast) 2 3
  • Activator Of 90 KDa Heat Shock Protein ATPase Homolog 2 3
  • Hch1 3

External Ids for AHSA2 Gene

Previous GeneCards Identifiers for AHSA2 Gene

  • GC02P061591
  • GC02P061362
  • GC02P061379
  • GC02P061316
  • GC02P061258
  • GC02P061404
  • GC02P061145

Summaries for AHSA2 Gene

GeneCards Summary for AHSA2 Gene

AHSA2 (AHA1, Activator Of Heat Shock 90kDa Protein ATPase Homolog 2 (Yeast)) is a Protein Coding gene. GO annotations related to this gene include chaperone binding and ATPase activator activity. An important paralog of this gene is AHSA1.

UniProtKB/Swiss-Prot for AHSA2 Gene

  • Co-chaperone that stimulates HSP90 ATPase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AHSA2 Gene

Genomics for AHSA2 Gene

Regulatory Elements for AHSA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AHSA2 Gene

61,177,418 bp from pter
61,191,203 bp from pter
13,786 bases
Plus strand

Genomic View for AHSA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AHSA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AHSA2 Gene

Proteins for AHSA2 Gene

  • Protein details for AHSA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Activator of 90 kDa heat shock protein ATPase homolog 2
    Protein Accession:
    Secondary Accessions:
    • B3KS51
    • D6W5E0
    • Q8NDU5

    Protein attributes for AHSA2 Gene

    299 amino acids
    Molecular mass:
    33806 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AHSA2 Gene


neXtProt entry for AHSA2 Gene

Proteomics data for AHSA2 Gene at MOPED

Post-translational modifications for AHSA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AHSA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for AHSA2

No data available for DME Specific Peptides for AHSA2 Gene

Domains for AHSA2 Gene

Protein Domains for AHSA2 Gene


Suggested Antigen Peptide Sequences for AHSA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q719I0
  • Belongs to the AHA1 family.
genes like me logo Genes that share domains with AHSA2: view

No data available for Gene Families for AHSA2 Gene

Function for AHSA2 Gene

Molecular function for AHSA2 Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone that stimulates HSP90 ATPase activity.

Gene Ontology (GO) - Molecular Function for AHSA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with AHSA2: view

Animal Model Products

miRNA for AHSA2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AHSA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AHSA2 Gene

Localization for AHSA2 Gene

Subcellular locations from

Jensen Localization Image for AHSA2 Gene COMPARTMENTS Subcellular localization image for AHSA2 gene
Compartment Confidence
mitochondrion 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AHSA2 Gene

Pathways for AHSA2 Gene

SuperPathways for AHSA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AHSA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress --
GO:0032781 positive regulation of ATPase activity IEA --
genes like me logo Genes that share ontologies with AHSA2: view

No data available for Pathways by source for AHSA2 Gene

Transcripts for AHSA2 Gene

Unigene Clusters for AHSA2 Gene

AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AHSA2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AHSA2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: -
SP7: - -
SP8: - -

Relevant External Links for AHSA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AHSA2 Gene

mRNA expression in normal human tissues for AHSA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for AHSA2 Gene Hs.655602

genes like me logo Genes that share expressions with AHSA2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for AHSA2 Gene

Orthologs for AHSA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AHSA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia AHSA2 35
  • 81.2 (n)
  • 73.68 (a)
(Pan troglodytes)
Mammalia AHSA2 35
  • 98.77 (n)
  • 97.04 (a)
AHSA2 36
  • 43 (a)
(Bos Taurus)
Mammalia AHSA2 36
  • 21 (a)
(Monodelphis domestica)
Mammalia AHSA2 36
  • 24 (a)
(Mus musculus)
Mammalia Ahsa2 36
  • 32 (a)
(Ornithorhynchus anatinus)
Mammalia AHSA2 36
  • 24 (a)
(Gallus gallus)
Aves AHSA2 36
  • 19 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1416 36
  • 10 (a)
(Caenorhabditis elegans)
Secernentea C01G10.8 36
  • 8 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AHA1 36
  • 6 (a)
HCH1 36
  • 5 (a)
Species with no ortholog for AHSA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for AHSA2 Gene

Gene Tree for AHSA2 (if available)
Gene Tree for AHSA2 (if available)

Paralogs for AHSA2 Gene

Paralogs for AHSA2 Gene

Selected SIMAP similar genes for AHSA2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AHSA2: view

Variants for AHSA2 Gene

Sequence variations from dbSNP and Humsavar for AHSA2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs746032 -- 61,177,873(+) CCTTT(C/T)CACTC utr-variant-5-prime, upstream-variant-2KB
rs777584 -- 61,183,211(+) tctca(A/G)tagcc intron-variant
rs777585 -- 61,185,424(+) TTTTA(C/T)TGAGA intron-variant
rs935860 -- 61,179,426(-) GACTC(C/G)TGTTC intron-variant
rs1809028 -- 61,186,588(+) AATGC(A/G)GTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AHSA2 Gene

Variant ID Type Subtype PubMed ID
nsv874211 CNV Loss 21882294
nsv874212 CNV Gain 21882294
nsv819479 CNV Loss 19587683

Relevant External Links for AHSA2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AHSA2 Gene

Disorders for AHSA2 Gene

Relevant External Links for AHSA2

Genetic Association Database (GAD)

No disorders were found for AHSA2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for AHSA2 Gene

Publications for AHSA2 Gene

  1. Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. (PMID: 12504007) Panaretou B. … Prodromou C. (Mol. Cell 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois P.C. … van Heel D.A. (Nat. Genet. 2010) 3 48
  4. Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone. (PMID: 12604615) Lotz G.P. … Obermann W.M.J. (J. Biol. Chem. 2003) 3 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for AHSA2 Gene

Sources for AHSA2 Gene

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