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Aliases for AHSA2 Gene

Aliases for AHSA2 Gene

  • AHA1, Activator Of Heat Shock 90kDa Protein ATPase Homolog 2 (Yeast) 2 3
  • Activator Of 90 KDa Heat Shock Protein ATPase Homolog 2 3
  • Hch1 3

External Ids for AHSA2 Gene

Summaries for AHSA2 Gene

GeneCards Summary for AHSA2 Gene

AHSA2 (AHA1, Activator Of Heat Shock 90kDa Protein ATPase Homolog 2 (Yeast)) is a Protein Coding gene. GO annotations related to this gene include chaperone binding and ATPase activator activity. An important paralog of this gene is AHSA1.

UniProtKB/Swiss-Prot for AHSA2 Gene

  • Co-chaperone that stimulates HSP90 ATPase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AHSA2 Gene

Genomics for AHSA2 Gene

Genomic Location for AHSA2 Gene

Start:
61,177,418 bp from pter
End:
61,191,203 bp from pter
Size:
13,786 bases
Orientation:
Plus strand

Genomic View for AHSA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AHSA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AHSA2 Gene

Regulatory Elements for AHSA2 Gene

Proteins for AHSA2 Gene

  • Protein details for AHSA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q719I0-AHSA2_HUMAN
    Recommended name:
    Activator of 90 kDa heat shock protein ATPase homolog 2
    Protein Accession:
    Q719I0
    Secondary Accessions:
    • B3KS51
    • D6W5E0
    • Q8NDU5

    Protein attributes for AHSA2 Gene

    Size:
    299 amino acids
    Molecular mass:
    33806 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AHSA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AHSA2 Gene

Proteomics data for AHSA2 Gene at MOPED

Post-translational modifications for AHSA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AHSA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AHSA2 Gene

Domains for AHSA2 Gene

Protein Domains for AHSA2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

AHSA2_HUMAN
Family:
  • Belongs to the AHA1 family.:
    • Q719I0
genes like me logo Genes that share domains with AHSA2: view

No data available for Gene Families for AHSA2 Gene

Function for AHSA2 Gene

Molecular function for AHSA2 Gene

UniProtKB/Swiss-Prot Function: Co-chaperone that stimulates HSP90 ATPase activity.

Gene Ontology (GO) - Molecular Function for AHSA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with AHSA2: view

miRNA for AHSA2 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AHSA2 Gene

Localization for AHSA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AHSA2 Gene COMPARTMENTS Subcellular localization image for AHSA2 gene
Compartment Confidence
mitochondrion 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for AHSA2 Gene

Pathways for AHSA2 Gene

SuperPathways for AHSA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AHSA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress --
GO:0032781 positive regulation of ATPase activity IEA --
genes like me logo Genes that share ontologies with AHSA2: view

No data available for Pathways by source for AHSA2 Gene

Transcripts for AHSA2 Gene

Unigene Clusters for AHSA2 Gene

AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AHSA2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7: - -
SP8: - -

Relevant External Links for AHSA2 Gene

GeneLoc Exon Structure for
AHSA2
ECgene alternative splicing isoforms for
AHSA2

Expression for AHSA2 Gene

mRNA expression in normal human tissues for AHSA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for AHSA2 Gene Hs.655602

genes like me logo Genes that share expressions with AHSA2: view

Orthologs for AHSA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AHSA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AHSA2 36
  • 98.77 (n)
  • 97.04 (a)
AHSA2 37
  • 43 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AHSA2 37
  • 21 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AHSA2 36
  • 81.2 (n)
  • 73.68 (a)
mouse
(Mus musculus)
Mammalia Ahsa2 37
  • 32 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AHSA2 37
  • 24 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AHSA2 37
  • 24 (a)
OneToOne
chicken
(Gallus gallus)
Aves AHSA2 37
  • 19 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1416 37
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C01G10.8 37
  • 8 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AHA1 37
  • 6 (a)
ManyToMany
HCH1 37
  • 5 (a)
ManyToMany
Species with no ortholog for AHSA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for AHSA2 Gene

ENSEMBL:
Gene Tree for AHSA2 (if available)
TreeFam:
Gene Tree for AHSA2 (if available)

Paralogs for AHSA2 Gene

Paralogs for AHSA2 Gene

Selected SIMAP similar genes for AHSA2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AHSA2: view

Variants for AHSA2 Gene

Sequence variations from dbSNP and Humsavar for AHSA2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs746032 -- 61,177,873(+) CCTTT(C/T)CACTC utr-variant-5-prime, upstream-variant-2KB
rs777584 -- 61,183,211(+) tctca(A/G)tagcc intron-variant
rs777585 -- 61,185,424(+) TTTTA(C/T)TGAGA intron-variant
rs935860 -- 61,179,426(-) GACTC(C/G)TGTTC intron-variant
rs1809028 -- 61,186,588(+) AATGC(A/G)GTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AHSA2 Gene

Variant ID Type Subtype PubMed ID
nsv874211 CNV Loss 21882294
nsv874212 CNV Gain 21882294
nsv819479 CNV Loss 19587683

Relevant External Links for AHSA2 Gene

HapMap Linkage Disequilibrium report
AHSA2

Disorders for AHSA2 Gene

Relevant External Links for AHSA2

Genetic Association Database (GAD)
AHSA2
genes like me logo Genes that share disorders with AHSA2: view

No data available for UniProtKB/Swiss-Prot for AHSA2 Gene

Publications for AHSA2 Gene

  1. Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. (PMID: 12504007) Panaretou B. … Prodromou C. (Mol. Cell 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois P.C. … van Heel D.A. (Nat. Genet. 2010) 3 49
  4. Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone. (PMID: 12604615) Lotz G.P. … Obermann W.M.J. (J. Biol. Chem. 2003) 3 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for AHSA2 Gene

Sources for AHSA2 Gene

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