AHSA2 Gene
protein-coding GIFtS: 46
GCID: GC02P061404
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AHA1, activator of heat shock 90kDa protein ATPase homolog...
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Aliases
for AHSA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| AHA1, Activator Of Heat Shock 90kDa Protein ATPase Homolog 2 (Yeast)1 2 | | Hch11 2 | | DKFZp564C2361 | | Activator Of 90 KDa Heat Shock Protein ATPase Homolog 22 |
Export aliases for AHSA2 gene to outside databasesPrevious GC identifers: GC02P061591 GC02P061362 GC02P061379 GC02P061316 GC02P061258 GC02P061145 |
Summaries
for AHSA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AHSA2_HUMAN, Q719I0Function: Co-chaperone that stimulates HSP90 ATPase activity (By similarity)
|
Genomic Views
for AHSA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AHSA2 gene promoter:
AML1a ATF-2 AREB6 MZF-1 PPAR-gamma1 FOXJ2 (long isoform) c-Myb PPAR-gamma2 FOXJ2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for AHSA2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AHSA2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p15 Ensembl cytogenetic band: 2p15 HGNC cytogenetic band: 2p14AHSA2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P061404: view genomic region
(about GC identifiers)
Start:
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61,404,553 bp from pter |
End:
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61,414,686 bp from pter |
Size:
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10,134 bases |
Orientation:
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plus strand |
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Proteins
for AHSA2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AHSA2_HUMAN, Q719I0 (See
protein sequence)Recommended Name: Activator of 90 kDa heat shock protein ATPase homolog 2 Size: 299 amino acids; 33806 Da
Secondary accessions: B3KS51 D6W5E0 Q8NDU5Alternative splicing: 3 isoforms: Q719I0-1 Q719I0-2 Q719I0-3 Explore the universe of human proteins at neXtProt for AHSA2: NX_Q719I0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q719I0
AHSA2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689605.1
ENSEMBL proteins: ENSP00000349525 ENSP00000377970 ENSP00000386721
Human Recombinant Protein Products:
AHSA2 Antibody Products:
Assay Products for AHSA2: |
Protein
Domains /
Families
for AHSA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AHSA2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q719I0ProtoNet protein and cluster: Q719I0 UniProtKB/Swiss-Prot: AHSA2_HUMAN, Q719I0Similarity: Belongs to the AHA1 family |
Function
for AHSA2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AHSA2_HUMAN, Q719I0Function: Co-chaperone that stimulates HSP90 ATPase activity (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AHSA2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AHSA2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: AHSA2 (NM_152392) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AHSA2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHSA2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHSA2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001671 | ATPase activator activity |
IEA | -- | | GO:0051087 | chaperone binding |
IEA | -- |
AHSA2 for ontologies About GeneDecksing
|
Pathways & Interactions
for AHSA2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AHSA2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for AHSA2 (Q719I03 ENSP000003495254) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006950 | response to stress |
IEA | -- |
AHSA2 for ontologies About GeneDecksing
|
Drugs & Compounds
for AHSA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AHSA2
Search CenterWatch for drugs/clinical trials and news about AHSA2
|
Transcripts
for AHSA2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AHSA2 gene: NM_152392.3 Unigene Cluster for AHSA2: AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast) Hs.655602 [show with all ESTs]Unigene Representative Sequence: BC05039511 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000357022(uc002sbb.2) ENST00000463681 ENST00000489653 ENST00000394457(uc002sbc.2)
ENST00000471542 ENST00000493310 ENST00000493628 ENST00000487904 ENST00000484217
ENST00000410073 ENST00000491217
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AHSA2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AHSA2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AHSA2 (NM_152392) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AHSA2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHSA2 |
Additional cDNA sequence: AF542548.1 AK092817.1 AL833813.1 BC030998.1 BC050395.1 BC063789.1 BC113671.1 BC117278.1 18 DOTS entries: DT.91762456 DT.100655337 DT.100029825 DT.100829594 DT.121644180 DT.454582 DT.100654230 DT.100655333 DT.310893 DT.211043 DT.100854990 DT.100804323 DT.99934461 DT.120949860 DT.120950002 DT.101864 DT.120949839 DT.120950004 24/283 AceView cDNA sequences (see all 283): AI744408 BM764149 BI491441 AW192707 AI801035 AL043694 CD723740 AL703557 BX119717 AW512908 AA688296 CA412239 AF542548 BE047823 W44861 CA440245 AI624581 BU741050 AK123709 AL833813 BM782250 AX747576 AI866638 AI984713
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for AHSA2 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 |
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| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | - | | - | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for AHSA2
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Expression
for AHSA2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AHSA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATTCTGTT
About this image
See AHSA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AHSA2
SOURCE GeneReport for Unigene cluster: Hs.655602
SABiosciences Custom PCR Arrays for AHSA2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AHSA2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat AHSA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AHSA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AHSA2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHSA2 |
Orthologs
for AHSA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for AHSA2 (if available)
TreeFam Gene Tree for AHSA2 (if available) |
Paralogs
for AHSA2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AHSA2 gene
- AHSA12
1 SIMAP similar gene for AHSA2 using alignment to 2 protein entries: AHSA2_HUMAN (see all proteins):AHSA1
AHSA2 for paralogs About GeneDecksing
|
Genomic Variants
for AHSA2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AHSA2 (61404553 - 61414686 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for AHSA2
1 Indel: 58994 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AHSA2 |
|
Disorders
/ Diseases
for AHSA2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AHSA2 for disorders About GeneDecksing
1  disease for AHSA2: About MalaCardsceliac disease
Export disorders for AHSA2 gene to outside databases
|
Publications
for AHSA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AHSA2 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with AHSA2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. (PubMed id 12504007)1, 2, 3 Panaretou B....Prodromou C. (2002)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone. (PubMed id 12604615)1, 9 Lotz G.P.... Obermann W.M.J. (2003)
- Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1 Dubois P.C....van Heel D.A. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites. (PubMed id 15570572)1 Ficarro S.B....Peters E.C. (2005)
- Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. (PubMed id 14739935)1 Meyer P....Pearl L.H. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for AHSA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AHSA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AHSA2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AHSA2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AHSA2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for AHSA2 gene:
Search GeneIP for patents involving AHSA2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AHSA2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for AHSA2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AHSA2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AHSA2 | | | OriGene Protein Over-expression Lysate for AHSA2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AHSA2 | | OriGene 3'-UTR Clone for AHSA2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AHSA2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AHSA2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for AHSA2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for AHSA2 | | OriGene Custom Protein Services for AHSA2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AHSA2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AHSA2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AHSA2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AHSA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AHSA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AHSA2 |
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| | | | Search Tocris compounds for AHSA2 |
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 | | | AHSA2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHSA2 |
|  |  |  | | | | ThermoFisher Antibodies for AHSA2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHSA2 |
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