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Aliases for AHSA1 Gene

Aliases for AHSA1 Gene

  • AHA1, Activator Of Heat Shock 90kDa Protein ATPase Homolog 1 (Yeast) 2 3
  • AHA1 3 4 6
  • C14orf3 3 4
  • P38 3 4
  • Activator Of 90 KDa Heat Shock Protein ATPase Homolog 1 3
  • Chromosome 14 Open Reading Frame 3 2

External Ids for AHSA1 Gene

Previous Symbols for AHSA1 Gene

  • C14orf3

Summaries for AHSA1 Gene

GeneCards Summary for AHSA1 Gene

AHSA1 (AHA1, Activator Of Heat Shock 90kDa Protein ATPase Homolog 1 (Yeast)) is a Protein Coding gene. Diseases associated with AHSA1 include cannabis abuse. Among its related pathways are Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). GO annotations related to this gene include chaperone binding and ATPase activator activity. An important paralog of this gene is AHSA2.

UniProtKB/Swiss-Prot for AHSA1 Gene

  • Cochaperone that stimulates HSP90 ATPase activity (By similarity). May affect a step in the endoplasmic reticulum to Golgi trafficking.

Gene Wiki entry for AHSA1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AHSA1 Gene

Genomics for AHSA1 Gene

Genomic Location for AHSA1 Gene

77,457,870 bp from pter
77,469,474 bp from pter
11,605 bases
Plus strand

Genomic View for AHSA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AHSA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AHSA1 Gene

Regulatory Elements for AHSA1 Gene

Proteins for AHSA1 Gene

  • Protein details for AHSA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Activator of 90 kDa heat shock protein ATPase homolog 1
    Protein Accession:
    Secondary Accessions:
    • B2R9L2
    • B4DUR9
    • Q96IL6
    • Q9P060

    Protein attributes for AHSA1 Gene

    338 amino acids
    Molecular mass:
    38274 Da
    Quaternary structure:
    • Interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatitis virus glycoprotein (VSV G). Interacts with GCH1. Interacts with SRPK1.

    Three dimensional structures from OCA and Proteopedia for AHSA1 Gene

    Alternative splice isoforms for AHSA1 Gene


neXtProt entry for AHSA1 Gene

Proteomics data for AHSA1 Gene at MOPED

Post-translational modifications for AHSA1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys3, Lys94, Lys212, Lys249, and Lys328

No data available for DME Specific Peptides for AHSA1 Gene

Domains for AHSA1 Gene

Protein Domains for AHSA1 Gene

Suggested Antigen Peptide Sequences for AHSA1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AHA1 family.:
    • O95433
genes like me logo Genes that share domains with AHSA1: view

No data available for Gene Families for AHSA1 Gene

Function for AHSA1 Gene

Molecular function for AHSA1 Gene

UniProtKB/Swiss-Prot Function: Cochaperone that stimulates HSP90 ATPase activity (By similarity). May affect a step in the endoplasmic reticulum to Golgi trafficking.
UniProtKB/Swiss-Prot Induction: By heat shock and treatment with the HSP90 inhibitor 17-demethoxygeldanamycin (17AAG).

Gene Ontology (GO) - Molecular Function for AHSA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IDA 12504007
GO:0005515 protein binding IPI 12604615
GO:0051087 chaperone binding IDA 12504007
genes like me logo Genes that share ontologies with AHSA1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AHSA1 Gene

Localization for AHSA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AHSA1 Gene

Cytoplasm, cytosol. Endoplasmic reticulum. Note=May transiently interact with the endoplasmic reticulum.

Subcellular locations from

Jensen Localization Image for AHSA1 Gene COMPARTMENTS Subcellular localization image for AHSA1 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for AHSA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with AHSA1: view

Pathways for AHSA1 Gene

genes like me logo Genes that share pathways with AHSA1: view

Pathways by source for AHSA1 Gene

Gene Ontology (GO) - Biological Process for AHSA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress IEA --
GO:0032781 positive regulation of ATPase activity IEA --
genes like me logo Genes that share ontologies with AHSA1: view

Transcripts for AHSA1 Gene

Unigene Clusters for AHSA1 Gene

AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AHSA1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - - - - -
SP3: - - - -
SP5: - - - -
SP6: - - - - - - - - - - - -
SP7: -

Relevant External Links for AHSA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AHSA1 Gene

mRNA expression in normal human tissues for AHSA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AHSA1 Gene

SOURCE GeneReport for Unigene cluster for AHSA1 Gene Hs.204041

mRNA Expression by UniProt/SwissProt for AHSA1 Gene

Tissue specificity: Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.
genes like me logo Genes that share expressions with AHSA1: view

No data available for mRNA differential expression in normal tissues for AHSA1 Gene

Orthologs for AHSA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AHSA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AHSA1 35
  • 99.8 (n)
  • 99.7 (a)
AHSA1 36
  • 100 (a)
(Bos Taurus)
Mammalia AHSA1 35
  • 92.5 (n)
  • 96.45 (a)
AHSA1 36
  • 96 (a)
(Canis familiaris)
Mammalia AHSA1 35
  • 94.08 (n)
  • 97.34 (a)
AHSA1 36
  • 97 (a)
(Mus musculus)
Mammalia Ahsa1 35
  • 91.03 (n)
  • 94.97 (a)
Ahsa1 16
Ahsa1 36
  • 95 (a)
(Monodelphis domestica)
Mammalia AHSA1 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia AHSA1 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Ahsa1 35
  • 90.14 (n)
  • 94.67 (a)
(Gallus gallus)
Aves AHSA1 35
  • 74.26 (n)
  • 77.22 (a)
AHSA1 36
  • 76 (a)
(Anolis carolinensis)
Reptilia AHSA1 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ahsa1 35
  • 67.16 (n)
  • 70.03 (a)
(Danio rerio)
Actinopterygii ahsa1 36
  • 60 (a)
ahsa1l 35
  • 65.78 (n)
  • 63.8 (a)
ahsa1l 36
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010514 35
  • 51.88 (n)
  • 46.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1416 35
  • 52.38 (n)
  • 44.35 (a)
CG1416 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea C01G10.8 36
  • 37 (a)
CELE_C01G10.8 35
  • 49.6 (n)
  • 38.02 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL090W 35
  • 41.91 (n)
  • 27.01 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AHA1 35
  • 43.27 (n)
  • 29.17 (a)
AHA1 36
  • 25 (a)
AHA1 38
HCH1 36
  • 28 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04147g 35
  • 43.57 (n)
  • 29.43 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G12050 35
  • 44.71 (n)
  • 34.44 (a)
(Oryza sativa)
Liliopsida Os.8027 35
Os08g0464000 35
  • 47.82 (n)
  • 37.39 (a)
(Triticum aestivum)
Liliopsida Ta.1318 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04087 35
  • 45.49 (n)
  • 32.57 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1711.08 35
  • 41.61 (n)
  • 30.82 (a)
Species with no ortholog for AHSA1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for AHSA1 Gene

Gene Tree for AHSA1 (if available)
Gene Tree for AHSA1 (if available)

Paralogs for AHSA1 Gene

Paralogs for AHSA1 Gene Pseudogenes for AHSA1 Gene

genes like me logo Genes that share paralogs with AHSA1: view

Variants for AHSA1 Gene

Sequence variations from dbSNP and Humsavar for AHSA1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7250 -- 77,469,177(+) CGGAC(A/G)CGACA synonymous-codon, reference
rs11982 -- 77,469,334(-) TGGGA(C/T)GATGC utr-variant-3-prime
rs760253 -- 77,468,374(+) ACTCC(A/G)TATGA intron-variant
rs760254 -- 77,468,629(+) ataat(C/T)acagc intron-variant
rs760255 -- 77,468,754(+) TTTTT(A/T)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AHSA1 Gene

Variant ID Type Subtype PubMed ID
nsv832835 CNV Gain 17160897
esv269366 CNV Insertion 20981092
esv273322 CNV Insertion 20981092

Relevant External Links for AHSA1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AHSA1 Gene

Disorders for AHSA1 Gene

(1) MalaCards Diseases for AHSA1 Gene

Search for AHSA1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for AHSA1 Gene

genes like me logo Genes that share disorders with AHSA1: view

No data available for UniProtKB/Swiss-Prot for AHSA1 Gene

Publications for AHSA1 Gene

  1. Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone. (PMID: 12604615) Lotz G.P. … Obermann W.M.J. (J. Biol. Chem. 2003) 3 4 23
  2. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. (PMID: 17110338) Wang X. … Balch W.E. (Cell 2006) 3 23
  3. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  5. p38: a novel protein that associates with the vesicular stomatitis virus glycoprotein. (PMID: 11554768) Sevier C.S. … Machamer C.E. (Biochem. Biophys. Res. Commun. 2001) 3 4

Products for AHSA1 Gene

Sources for AHSA1 Gene

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