Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AHSA1 Gene

Aliases for AHSA1 Gene

  • AHA1, Activator Of Heat Shock 90kDa Protein ATPase Homolog 1 (Yeast) 2 3 5
  • C14orf3 3 4
  • AHA1 3 4
  • P38 3 4
  • Chromosome 14 Open Reading Frame 3 2
  • HAha1 3

External Ids for AHSA1 Gene

Previous HGNC Symbols for AHSA1 Gene

  • C14orf3

Previous GeneCards Identifiers for AHSA1 Gene

  • GC14P075914
  • GC14P076994
  • GC14P077924
  • GC14P058090

Summaries for AHSA1 Gene

GeneCards Summary for AHSA1 Gene

AHSA1 (AHA1, Activator Of Heat Shock 90kDa Protein ATPase Homolog 1 (Yeast)) is a Protein Coding gene. Diseases associated with AHSA1 include Stomatitis. Among its related pathways are Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). GO annotations related to this gene include chaperone binding and ATPase activator activity. An important paralog of this gene is AHSA2.

UniProtKB/Swiss-Prot for AHSA1 Gene

  • Cochaperone that stimulates HSP90 ATPase activity (By similarity). May affect a step in the endoplasmic reticulum to Golgi trafficking.

Gene Wiki entry for AHSA1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AHSA1 Gene

Genomics for AHSA1 Gene

Regulatory Elements for AHSA1 Gene

Promoters for AHSA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AHSA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for AHSA1 Gene

77,457,870 bp from pter
77,469,474 bp from pter
11,605 bases
Plus strand

Genomic View for AHSA1 Gene

Genes around AHSA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AHSA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AHSA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AHSA1 Gene

Proteins for AHSA1 Gene

  • Protein details for AHSA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Activator of 90 kDa heat shock protein ATPase homolog 1
    Protein Accession:
    Secondary Accessions:
    • B2R9L2
    • B4DUR9
    • Q96IL6
    • Q9P060

    Protein attributes for AHSA1 Gene

    338 amino acids
    Molecular mass:
    38274 Da
    Quaternary structure:
    • Interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatitis virus glycoprotein (VSV G). Interacts with GCH1. Interacts with SRPK1.

    Three dimensional structures from OCA and Proteopedia for AHSA1 Gene

    Alternative splice isoforms for AHSA1 Gene


neXtProt entry for AHSA1 Gene

Proteomics data for AHSA1 Gene at MOPED

Post-translational modifications for AHSA1 Gene

  • Ubiquitination at Lys 3, Lys 94, Lys 249, and Lys 328
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for AHSA1 Gene

Domains & Families for AHSA1 Gene

Protein Domains for AHSA1 Gene

Suggested Antigen Peptide Sequences for AHSA1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AHA1 family.
  • Belongs to the AHA1 family.
genes like me logo Genes that share domains with AHSA1: view

No data available for Gene Families for AHSA1 Gene

Function for AHSA1 Gene

Molecular function for AHSA1 Gene

UniProtKB/Swiss-Prot Function:
Cochaperone that stimulates HSP90 ATPase activity (By similarity). May affect a step in the endoplasmic reticulum to Golgi trafficking.
UniProtKB/Swiss-Prot Induction:
By heat shock and treatment with the HSP90 inhibitor 17-demethoxygeldanamycin (17AAG).

Gene Ontology (GO) - Molecular Function for AHSA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051087 chaperone binding IEA,IDA 12504007
genes like me logo Genes that share ontologies with AHSA1: view
genes like me logo Genes that share phenotypes with AHSA1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AHSA1 Gene

Localization for AHSA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AHSA1 Gene

Cytoplasm, cytosol. Endoplasmic reticulum. Note=May transiently interact with the endoplasmic reticulum.

Subcellular locations from

Jensen Localization Image for AHSA1 Gene COMPARTMENTS Subcellular localization image for AHSA1 gene
Compartment Confidence
cytosol 5
extracellular 5
endoplasmic reticulum 3
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AHSA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with AHSA1: view

Pathways & Interactions for AHSA1 Gene

genes like me logo Genes that share pathways with AHSA1: view

Pathways by source for AHSA1 Gene

Gene Ontology (GO) - Biological Process for AHSA1 Gene


No data available for SIGNOR curated interactions for AHSA1 Gene

Drugs & Compounds for AHSA1 Gene

No Compound Related Data Available

Transcripts for AHSA1 Gene

Unigene Clusters for AHSA1 Gene

AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AHSA1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - - - - -
SP3: - - - -
SP5: - - - -
SP6: - - - - - - - - - - - -
SP7: -

Relevant External Links for AHSA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AHSA1 Gene

mRNA expression in normal human tissues for AHSA1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AHSA1 Gene

SOURCE GeneReport for Unigene cluster for AHSA1 Gene Hs.204041

mRNA Expression by UniProt/SwissProt for AHSA1 Gene

Tissue specificity: Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.
genes like me logo Genes that share expression patterns with AHSA1: view

Protein tissue co-expression partners for AHSA1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for AHSA1 Gene

Orthologs for AHSA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AHSA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AHSA1 35
  • 92.5 (n)
  • 96.45 (a)
AHSA1 36
  • 96 (a)
(Canis familiaris)
Mammalia AHSA1 35
  • 94.08 (n)
  • 97.34 (a)
AHSA1 36
  • 97 (a)
(Mus musculus)
Mammalia Ahsa1 35
  • 91.03 (n)
  • 94.97 (a)
Ahsa1 16
Ahsa1 36
  • 95 (a)
(Pan troglodytes)
Mammalia AHSA1 35
  • 99.8 (n)
  • 99.7 (a)
AHSA1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ahsa1 35
  • 90.14 (n)
  • 94.67 (a)
(Monodelphis domestica)
Mammalia AHSA1 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia AHSA1 36
  • 72 (a)
(Gallus gallus)
Aves AHSA1 35
  • 74.26 (n)
  • 77.22 (a)
AHSA1 36
  • 76 (a)
(Anolis carolinensis)
Reptilia AHSA1 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ahsa1 35
  • 67.16 (n)
  • 70.03 (a)
(Danio rerio)
Actinopterygii ahsa1l 35
  • 65.78 (n)
  • 63.8 (a)
ahsa1 36
  • 60 (a)
ahsa1l 36
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010514 35
  • 51.88 (n)
  • 46.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1416 35
  • 52.38 (n)
  • 44.35 (a)
CG1416 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea CELE_C01G10.8 35
  • 49.6 (n)
  • 38.02 (a)
C01G10.8 36
  • 37 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL090W 35
  • 41.91 (n)
  • 27.01 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04147g 35
  • 43.57 (n)
  • 29.43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AHA1 35
  • 43.27 (n)
  • 29.17 (a)
AHA1 36
  • 25 (a)
HCH1 36
  • 28 (a)
AHA1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G12050 35
  • 44.71 (n)
  • 34.44 (a)
(Oryza sativa)
Liliopsida Os.8027 35
Os08g0464000 35
  • 47.82 (n)
  • 37.39 (a)
(Triticum aestivum)
Liliopsida Ta.1318 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04087 35
  • 45.49 (n)
  • 32.57 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1711.08 35
  • 41.61 (n)
  • 30.82 (a)
Species with no ortholog for AHSA1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for AHSA1 Gene

Gene Tree for AHSA1 (if available)
Gene Tree for AHSA1 (if available)

Paralogs for AHSA1 Gene

Paralogs for AHSA1 Gene Pseudogenes for AHSA1 Gene

genes like me logo Genes that share paralogs with AHSA1: view

Variants for AHSA1 Gene

Sequence variations from dbSNP and Humsavar for AHSA1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7250 -- 77,469,177(+) CGGAC(A/G)CGACA reference, synonymous-codon
rs11982 -- 77,469,334(-) TGGGA(C/T)GATGC utr-variant-3-prime
rs7141931 -- 77,465,158(+) TTAGA(G/T)CCCTG intron-variant
rs7142380 -- 77,464,888(+) AGACC(C/T)TTAGA intron-variant
rs8018509 -- 77,461,940(+) TTGTC(C/T)CACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AHSA1 Gene

Variant ID Type Subtype PubMed ID
nsv832835 CNV Gain 17160897
esv269366 CNV Insertion 20981092
esv273322 CNV Insertion 20981092

Variation tolerance for AHSA1 Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AHSA1 Gene

Disorders for AHSA1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AHSA1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards
Search AHSA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AHSA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with AHSA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AHSA1 Gene

Publications for AHSA1 Gene

  1. Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone. (PMID: 12604615) Lotz G.P. … Obermann W.M.J. (J. Biol. Chem. 2003) 3 4 23 67
  2. AHSA1 regulates proliferation, apoptosis, migration, and invasion of osteosarcoma. (PMID: 26796264) Shao J. … Li Y. (Biomed. Pharmacother. 2016) 2 3
  3. Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia. (PMID: 18556464) Sun F. … Frizzell R.A. (FASEB J. 2008) 3 23
  4. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. (PMID: 17110338) Wang X. … Balch W.E. (Cell 2006) 3 23
  5. Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast. (PMID: 25486457) Synoradzki K. … Bieganowski P. (Biochim. Biophys. Acta 2015) 3

Products for AHSA1 Gene

Sources for AHSA1 Gene