Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AHSA1 Gene

protein-coding   GIFtS: 57
GCID: GC14P077924

AHA1, activator of heat shock 90kDa protein ATPase homolog...

(Previous name: chromosome 14 open reading frame 3 )
(Previous symbol: C14orf3)
 Explore 4 diseases affiliated with
AHSA1 via our new
 Human Malady Compendium 
Biological research products
for AHSA1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
AHA1, Activator Of Heat Shock 90kDa Protein ATPase Homolog 1 (Yeast)1 2
C14orf31 2 3
P381
AHA12 3
Chromosome 14 Open Reading Frame 31
Activator Of 90 KDa Heat Shock Protein ATPase Homolog 12

External Ids:    HGNC: 11891   Entrez Gene: 105982   Ensembl: ENSG000001005917   OMIM: 6084665   UniProtKB: O954333   

Export aliases for AHSA1 gene to outside databases

Previous GC identifers: GC14P075914 GC14P076994 GC14P058090


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: AHSA1_HUMAN, O95433
Function: Cochaperone that stimulates HSP90 ATPase activity (By similarity). May affect a step in the endoplasmic
reticulum to Golgi trafficking

Gene Wiki entry for AHSA1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AHSA1 gene promoter:
         ISGF-3   RP58   FOXF2   Pax-5   MIF-1   MZF-1   IRF-2   PPAR-gamma1   c-Myb   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAHSA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AHSA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AHSA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q

AHSA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AHSA1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P077924:  view genomic region     (about GC identifiers)

Start:
77,924,213 bp from pter      End:
77,935,817 bp from pter
Size:
11,605 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AHSA1_HUMAN, O95433 (See protein sequence)
Recommended Name: Activator of 90 kDa heat shock protein ATPase homolog 1  
Size: 338 amino acids; 38274 Da
Subunit: Interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatitis virus glycoprotein (VSV
G). Interacts with GCH1. Interacts with SRPK1
Subcellular location: Cytoplasm, cytosol. Endoplasmic reticulum. Note=May transiently interact with the endoplasmic
reticulum
1 PDB 3D structure from and Proteopedia for AHSA1:
1X53 (3D)    
Secondary accessions: B2R9L2 Q96IL6 Q9P060

Explore the universe of human proteins at neXtProt for AHSA1: NX_O95433

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95433

  • AHSA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036243.1  
    ENSEMBL proteins: 
     ENSP00000451569   ENSP00000216479   ENSP00000440108   ENSP00000451467   ENSP00000451475  
     ENSP00000452127   ENSP00000450890   ENSP00000451474  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for AHSA1
    OriGene Purified Protein: AHSA1
    OriGene Protein Over-expression Lysate: AHSA1
    OriGene Custom Protein Services for AHSA1 
    GenScript Custom Purified and Recombinant Proteins Services for AHSA1
    Novus Biologicals AHSA1 Proteins
    Novus Biologicals AHSA1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for AHSA1
    Uscn Proteins for AHSA1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005829cytosol IEA--


    AHSA1 for ontologies           About GeneDecksing



    AHSA1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: AHSA1
    OriGene Custom Antibody Services for AHSA1 
    GenScript Superior Antibodies for AHSA1
    Novus Biologicals AHSA1 Antibodies
    Search for Antibodies for AHSA1 at Abcam  
    Uscn Antibodies for AHSA1
    Search ThermoFisher Antibodies for AHSA1

    Assay Products for AHSA1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AHSA1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for AHSA1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    AHSA1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015310 AHSA1_N
     IPR023393 START-like_dom
     IPR013538 Activator_of_Hsp90_ATPase

    Graphical View of Domain Structure for InterPro Entry O95433

    ProtoNet protein and cluster: O95433

    1 Blocks protein family: IPB013538 Activator of Hsp90 ATPase homologue 1-like

    UniProtKB/Swiss-Prot: AHSA1_HUMAN, O95433
    Similarity: Belongs to the AHA1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: AHSA1_HUMAN, O95433
    Function: Cochaperone that stimulates HSP90 ATPase activity (By similarity). May affect a step in the endoplasmic
    reticulum to Golgi trafficking
    Induction: By heat shock and treatment with the HSP90 inhibitor 17-demethoxygeldanamycin (17AAG)

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: AHSA1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AHSA1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AHSA1
    SwitchGear 3'UTR luciferase reporter plasmidAHSA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AHSA1 (see all 4)
    OriGene shRNA RFP: AHSA1
    OriGene siRNA: AHSA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AHSA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AHSA1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AHSA1 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AHSA1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: AHSA1 (NM_012111)
    Sino Biological Human cDNA Clone for AHSA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AHSA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHSA1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AHSA1
    Search LifeMap BioReagents cell lines for AHSA1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHSA1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001671ATPase activator activity ISS--
    GO:0005515protein binding IPI19875381
    GO:0051087chaperone binding IDA12504007


    AHSA1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)1.00
    CFTR folding and maturation (norm and CF)0.37

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for AHSA1
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    CFTR folding and maturation (norm and CF)


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AHSA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/222 Interacting proteins for AHSA1 (O954331, 2, 3 ENSP000002164794) via UniProtKB, MINT, STRING, and/or I2D (see all 222)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GCH1P307931, 3, ENSP000003788904EBI-448610,EBI-958183 I2D: score=4 STRING: ENSP00000378890
    CCT6AP402272, 3, ENSP000002756034MINT-8380842 I2D: score=2 STRING: ENSP00000275603
    CCT4P509912, 3MINT-8380842 I2D: score=2 
    HSPA8P111422, 3MINT-8380842 I2D: score=1 
    TCP1P179872, 3MINT-8380842 I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding ISS--
    GO:0006950response to stress ISS--
    GO:0032781positive regulation of ATPase activity ISS--


    AHSA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AHSA1
    Search CenterWatch for drugs/clinical trials and news about AHSA1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AHSA1 gene: 
    NM_012111.2  

    Unigene Cluster for AHSA1:

    AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
    Hs.204041  [show with all ESTs]
    Unigene Representative Sequence: BF686657
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555133 ENST00000216479(uc001xtw.3) ENST00000535854(uc010tvk.1)
    ENST00000554156 ENST00000555517 ENST00000556963 ENST00000556866 ENST00000553374
    ENST00000555457 ENST00000555729 ENST00000555473 ENST00000556369 ENST00000557476


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: AHSA1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AHSA1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AHSA1
    SwitchGear 3'UTR luciferase reporter plasmidAHSA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AHSA1 (see all 4)
    OriGene shRNA RFP: AHSA1
    OriGene siRNA: AHSA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AHSA1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AHSA1 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AHSA1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: AHSA1 (NM_012111)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AHSA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHSA1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AHSA1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AHSA1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AHSA1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AHSA1

    Additional cDNA sequence: 

    AF161440.1 AF164791.1 AJ243310.1 AK313824.1 BC000321.2 BC007398.2 

    16 DOTS entries:

    DT.80100636  DT.100766646  DT.100816509  DT.40200794  DT.92455890  DT.99935491  DT.100826345  DT.102832228 
    DT.120768451  DT.95358624  DT.95358625  DT.100826349  DT.100826355  DT.120768455  DT.92455894  DT.97790522 

    24/544 AceView cDNA sequences (see all 544):

    CR620829 AW161228 AI187984 CR618207 CR617792 CA425677 BU069197 BC000321 
    T33157 BM807037 BQ429990 BE383373 CR612927 BU540568 BE909121 CR594235 
    BU155978 AA135643 BQ773555 BM714903 CR616582 BQ006223 BF971896 BQ679871 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for AHSA1 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11
    SP1:                                            -           -                                                                       -         
    SP2:        -     -     -     -                 -           -                                                                                 
    SP3:                                            -           -           -     -                                                               
    SP4:                                                                                                                                          
    SP5:                                            -           -     -     -                                                                     


    ECgene alternative splicing isoforms for AHSA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AHSA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTCTGCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See AHSA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AHSA1

    SOURCE GeneReport for Unigene cluster: Hs.204041

    UniProtKB/Swiss-Prot: AHSA1_HUMAN, O95433
    Tissue specificity: Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower
    levels, liver and placenta

        SABiosciences Custom PCR Arrays for AHSA1
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AHSA1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AHSA1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AHSA1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AHSA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHSA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AHSA1 gene from 10/34 species (see all 34)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ahsa11 , 5 AHA1, activator of heat shock protein ATPase homolog more5
    AHA1, activator of heat shock protein ATPase 11
    91.03(n)1
    94.97(a)1
      12 (41.47 cM)5
    2177371  NM_146036.11  NP_666148.11 
     872667285 
    chicken
    (Gallus gallus)
    Aves AHSA11 AHA1, activator of heat shock 90kDa protein ATPase more 74.26(n)
    77.22(a)
      423378  XM_421292.2  XP_421292.1 
    lizard
    (Anolis carolinensis)
    Reptilia AHSA16
    --
    76(a)
    1 ↔ 1
    1(20673932-20690649)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041491.12   -- 74.52(n)    BC041491.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055523.12   -- 79.16(n)    BC055523.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG14161 CG1416 51.49(n)
    44.05(a)
      35426  NM_165398.1  NP_724361.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_C01G10.81 Protein C01G10.8 50.55(n)
    38.81(a)
      180017  NM_074314.3  NP_506715.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AHA1(YDR214W)4
    AHA11
    Co-chaperone that binds to Hsp82p and activates its more4
    Aha1p1
    43.55(n)1
    29.35(a)1
      4(892875-893927)4
    8518001, 4  NP_010500.31  NP_010500.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G120501 Aha1 domain-containing protein 44.71(n)
    34.44(a)
      820379  NM_112039.2  NP_566410.1 
    rice
    (Oryza sativa)
    Liliopsida Os.80272 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 80(n)    AK059195.1 


    ENSEMBL Gene Tree for AHSA1 (if available)
    TreeFam Gene Tree for AHSA1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AHSA1 gene
    AHSA22  
    18/23 SIMAP similar genes for AHSA1 using alignment to 8 protein entries:     AHSA1_HUMAN (see all proteins) (see all similar genes):
    RPS6KA5    FAM138A    FAM138B    FAM138C    FAM138F    C14orf105
    OK/SW-cl.41    PLA2G15    DNAPTP3    FAM138D    LINC00269    LSM12
    CHEK2    FP6651    CGRRF1    FP6778    SLC35E3    CCT3

    AHSA1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for AHSA1
    PGOHUM00000263040


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/333 NCBI SNPs in AHSA1 are shown (see all 333    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs287603541,2
    --58088736(+) ACACAC/TGTCAG 5 -- int10--------
    rs803000281,2
    C,F,--58088849(+) AAGAGT/GTCAGT 5 -- int11Minor allele frequency- G:0.14WA 118
    rs1128982931,2
    C,--58088956(+) ATTTTT/ACACTT 5 -- int11Minor allele frequency- A:0.50NA 2
    rs768695421,2
    C,F,--58089225(+) GCTTCA/GACATG 5 -- int11Minor allele frequency- G:0.14WA 118
    rs760082501,2
    C,F,--58089395(+) AACCAC/GCTACT 5 -- int11Minor allele frequency- G:0.14WA 118
    rs788838411,2
    F,--58089920(+) GGCGGA/TGAGAA 5 -- ut511Minor allele frequency- T:0.03NA 120
    rs560290591,2
    C,--58090050(+) ACCGTG/ACTAGG 5 -- us2k12Minor allele frequency- A:0.07WA 120
    rs178242141,2
    C,F,H,--58090189(+) TTCCTA/GTGGGT 5 -- us2k121Minor allele frequency- G:0.09NA NS EA WA 2478
    rs791000701,2
    C,F,--58090872(+) GCTTAT/CTACAC 5 -- us2k11Minor allele frequency- C:0.13WA 118
    rs1162178171,2
    C,F,--58091116(+) GGAACT/CCCAGG 5 -- us2k11Minor allele frequency- C:0.06WA 118

    HapMap Linkage Disequilibrium report for AHSA1 (77924213 - 77935817 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for AHSA1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AHSA1
    DNA2.0 Custom Variant and Variant Library Synthesis for AHSA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    AHSA1 for disorders           About GeneDecksing

    OMIM gene information: 608466    OMIM disorders: --

    4 diseases for AHSA1:    About MalaCards
    cystic fibrosis    stomatitis    fibrosis    malaria

    1 disease from the University of Copenhagen DISEASES database for AHSA1:
    Cannabis abuse

    Export disorders for AHSA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AHSA1 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with AHSA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone. (PubMed id 12604615)1, 2, 9 Lotz G.P.... Obermann W.M.J. (2003)
    2. A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions. (PubMed id 16696853)1, 2 Swick L. and Kapatos G. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    5. Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. (PubMed id 12504007)1, 2 Panaretou B....Prodromou C. (2002)
    6. p38: a novel protein that associates with the vesicular stomatitis virus glycoprotein. (PubMed id 11554768)1, 2 Sevier C.S. and Machamer C.E. (2001)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    8. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    9. Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia. (PubMed id 18556464)1, 9 Sun F....Frizzell R.A. (2008)
    10. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. (PubMed id 17110338)1, 9 Wang X....Balch W.E. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10598 HGNC: 1189 AceView: AHSA1 Ensembl:ENSG00000100591 euGenes: HUgn10598
    ECgene: AHSA1 H-InvDB: AHSA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AHSA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AHSA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AHSA1 gene:
    Search GeneIP for patents involving AHSA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for AHSA1   OriGene shRNA RFP for AHSA1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AHSA1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AHSA1  
     OriGene Protein Over-expression Lysate for AHSA1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for AHSA1   OriGene 3'-UTR Clone for AHSA1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AHSA1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AHSA1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for AHSA1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AHSA1   OriGene Custom Protein Services for AHSA1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AHSA1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AHSA1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AHSA1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AHSA1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AHSA1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AHSA1
     GenScript Custom Purified and Recombinant Proteins Services for AHSA1 GenScript cDNA clones with any tag delivered in your preferred vector for AHSA1
     GenScript Custom Assay Services for AHSA1 GenScript Superior Antibodies for AHSA1
     GenScript Custom overexpressing Cell Line Services for AHSA1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in AHSA1 promoter
     Search Chromatin IP Primers for AHSA1
     RT2 qPCR Primer Assay in human, mouse, rat AHSA1
     GNC Network for AHSA1
     SABiosciences Custom PCR Arrays for AHSA1
     Search Tocris compounds for AHSA1
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for AHSA1
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Proteins for AHSA1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     AHSA1 antibodies
     AHSA1 proteins
     AHSA1 lysates
     Search for Antibodies for AHSA1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for AHSA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for AHSA1




     AHSA1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for AHSA1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHSA1
     SwitchGear 3'UTR luciferase reporter plasmids for AHSA1
     SwitchGear Promoter luciferase reporter plasmids for AHSA1
     Search ThermoFisher Antibodies for AHSA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHSA1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AHSA1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4