Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AHSA1 Gene

Aliases for AHSA1 Gene

  • Activator Of HSP90 ATPase Activity 1 2 3
  • C14orf3 3 4
  • AHA1 3 4
  • P38 3 4
  • AHA1, Activator Of Heat Shock 90kDa Protein ATPase Homolog 1 (Yeast) 2
  • AHA1, Activator Of Heat Shock 90kDa Protein ATPase Homolog 1 3
  • Activator Of 90 KDa Heat Shock Protein ATPase Homolog 1 3
  • Activator Of Hsp90 ATPase Activity 1 5
  • Chromosome 14 Open Reading Frame 3 2
  • HAha1 3

External Ids for AHSA1 Gene

Previous HGNC Symbols for AHSA1 Gene

  • C14orf3

Previous GeneCards Identifiers for AHSA1 Gene

  • GC14P075914
  • GC14P076994
  • GC14P077924
  • GC14P058090

Summaries for AHSA1 Gene

GeneCards Summary for AHSA1 Gene

AHSA1 (Activator Of HSP90 ATPase Activity 1) is a Protein Coding gene. Diseases associated with AHSA1 include Stomatitis. Among its related pathways are Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). GO annotations related to this gene include chaperone binding and ATPase activator activity. An important paralog of this gene is AHSA2.

UniProtKB/Swiss-Prot for AHSA1 Gene

  • Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360).

Gene Wiki entry for AHSA1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AHSA1 Gene

Genomics for AHSA1 Gene

Regulatory Elements for AHSA1 Gene

Enhancers for AHSA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F077312 1.4 FANTOM5 Ensembl ENCODE 10.4 -142.4 -142399 5.7 TBP PKNOX1 INSM2 ARID4B SIN3A ZNF2 RAD21 ZNF143 RCOR1 FOS TMED8 GSTZ1 NGB ZDHHC22 ENSG00000201384 SAMD15 AHSA1 VIPAS39 TMEM63C POMT2
GH14F077301 1.3 Ensembl ENCODE 10.5 -152.8 -152787 6.5 PKNOX1 ATF1 ARID4B SIN3A FEZF1 ZNF2 CBX5 ZNF143 ZNF207 FOS IRF2BPL GSTZ1 ALKBH1 NGB MIR1260A ZDHHC22 ENSG00000201384 SAMD15 TMED8 RPL21P10
GH14F077371 1.1 Ensembl ENCODE 10.6 -84.9 -84927 3.3 PKNOX1 INSM2 ZNF366 FOS MIXL1 USF2 JUNB TBX21 KAT8 RAD51 TMED8 POMT2 GSTZ1 ENSG00000259081 AHSA1 VIPAS39 SAMD15 LOC100422225
GH14F077406 1 Ensembl ENCODE 11.2 -50.9 -50869 2.0 CTCF HDAC1 TAL1 NR2F1 DPF2 ARID1B ZFHX2 GATA3 KLF16 SMARCA4 SAMD15 TMED8 AHSA1 VIPAS39 POMT2 GSTZ1 GC14M077403 ENSG00000280308
GH14F077359 1 FANTOM5 10.6 -97.9 -97948 0.1 ATF1 PKNOX1 ARNT CREB3L1 NFRKB ZNF766 GATA2 CREM ZBTB2 ZBTB11 TMED8 GSTZ1 POMT2 VIPAS39 AHSA1 LOC100422225 SAMD15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AHSA1 on UCSC Golden Path with GeneCards custom track

Promoters for AHSA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001459043 30 3001 HDGF PKNOX1 CREB3L1 ARNT MLX ARID4B SIN3A YBX1 DMAP1 ZNF2

Genomic Location for AHSA1 Gene

Chromosome:
14
Start:
77,457,870 bp from pter
End:
77,469,474 bp from pter
Size:
11,605 bases
Orientation:
Plus strand

Genomic View for AHSA1 Gene

Genes around AHSA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AHSA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AHSA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AHSA1 Gene

Proteins for AHSA1 Gene

  • Protein details for AHSA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95433-AHSA1_HUMAN
    Recommended name:
    Activator of 90 kDa heat shock protein ATPase homolog 1
    Protein Accession:
    O95433
    Secondary Accessions:
    • B2R9L2
    • B4DUR9
    • Q96IL6
    • Q9P060

    Protein attributes for AHSA1 Gene

    Size:
    338 amino acids
    Molecular mass:
    38274 Da
    Quaternary structure:
    • Interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatitis virus glycoprotein (VSV G). Interacts with GCH1. Interacts with SRPK1. Interacts with FLCN (PubMed:27353360). Interacts with HSP90AA1; the interaction activates HSP90AA1 ATPase activity (PubMed:27353360).

    Three dimensional structures from OCA and Proteopedia for AHSA1 Gene

    Alternative splice isoforms for AHSA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AHSA1 Gene

Post-translational modifications for AHSA1 Gene

  • Ubiquitination at Lys 3, Lys 94, Lys 249, and Lys 328
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for AHSA1 Gene

Domains & Families for AHSA1 Gene

Suggested Antigen Peptide Sequences for AHSA1 Gene

Graphical View of Domain Structure for InterPro Entry

O95433

UniProtKB/Swiss-Prot:

AHSA1_HUMAN :
  • Belongs to the AHA1 family.
Family:
  • Belongs to the AHA1 family.
genes like me logo Genes that share domains with AHSA1: view

No data available for Gene Families for AHSA1 Gene

Function for AHSA1 Gene

Molecular function for AHSA1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360).
UniProtKB/Swiss-Prot Induction:
By heat shock and treatment with the HSP90 inhibitor 17-demethoxygeldanamycin (17AAG).

Gene Ontology (GO) - Molecular Function for AHSA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IDA 12504007
GO:0005515 protein binding IPI 12604615
GO:0051087 chaperone binding IEA,IDA 12504007
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with AHSA1: view
genes like me logo Genes that share phenotypes with AHSA1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AHSA1 Gene

Localization for AHSA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AHSA1 Gene

Cytoplasm, cytosol. Endoplasmic reticulum. Note=May transiently interact with the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AHSA1 gene
Compartment Confidence
extracellular 5
cytosol 5
endoplasmic reticulum 3
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AHSA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol IEA --
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with AHSA1: view

Pathways & Interactions for AHSA1 Gene

genes like me logo Genes that share pathways with AHSA1: view

Pathways by source for AHSA1 Gene

Gene Ontology (GO) - Biological Process for AHSA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress IEA --
GO:0032781 positive regulation of ATPase activity IEA --
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with AHSA1: view

No data available for SIGNOR curated interactions for AHSA1 Gene

Transcripts for AHSA1 Gene

Unigene Clusters for AHSA1 Gene

AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AHSA1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - - - - -
SP3: - - - -
SP4:
SP5: - - - -
SP6: - - - - - - - - - - - -
SP7: -
SP8:

Relevant External Links for AHSA1 Gene

GeneLoc Exon Structure for
AHSA1
ECgene alternative splicing isoforms for
AHSA1

Expression for AHSA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AHSA1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AHSA1 Gene



Protein tissue co-expression partners for AHSA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AHSA1 Gene:

AHSA1

SOURCE GeneReport for Unigene cluster for AHSA1 Gene:

Hs.204041

mRNA Expression by UniProt/SwissProt for AHSA1 Gene:

O95433-AHSA1_HUMAN
Tissue specificity: Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.
genes like me logo Genes that share expression patterns with AHSA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for AHSA1 Gene

Orthologs for AHSA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AHSA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AHSA1 34 35
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia AHSA1 35 34
  • 94.08 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AHSA1 35 34
  • 92.5 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ahsa1 16 35 34
  • 91.03 (n)
rat
(Rattus norvegicus)
Mammalia Ahsa1 34
  • 90.14 (n)
oppossum
(Monodelphis domestica)
Mammalia AHSA1 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AHSA1 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves AHSA1 35 34
  • 74.26 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AHSA1 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ahsa1 34
  • 67.16 (n)
zebrafish
(Danio rerio)
Actinopterygii ahsa1l 34 35
  • 65.78 (n)
ahsa1 35
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1416 34 35
  • 52.38 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010514 34
  • 51.88 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_C01G10.8 34
  • 49.6 (n)
C01G10.8 35
  • 37 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04147g 34
  • 43.57 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AHA1 34 35 37
  • 43.27 (n)
HCH1 35
  • 28 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL090W 34
  • 41.91 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G12050 34
  • 44.71 (n)
rice
(Oryza sativa)
Liliopsida Os08g0464000 34
  • 47.82 (n)
Os.8027 34
wheat
(Triticum aestivum)
Liliopsida Ta.1318 34
bread mold
(Neurospora crassa)
Ascomycetes NCU04087 34
  • 45.49 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1711.08 34
  • 41.61 (n)
Species where no ortholog for AHSA1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for AHSA1 Gene

ENSEMBL:
Gene Tree for AHSA1 (if available)
TreeFam:
Gene Tree for AHSA1 (if available)

Paralogs for AHSA1 Gene

Paralogs for AHSA1 Gene

Pseudogenes.org Pseudogenes for AHSA1 Gene

genes like me logo Genes that share paralogs with AHSA1: view

Variants for AHSA1 Gene

Sequence variations from dbSNP and Humsavar for AHSA1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10129572 -- 77,463,600(+) AAAAA(A/C)AAAAA intron-variant
rs10144645 -- 77,466,137(+) cggcc(A/G)TATTT intron-variant
rs10145195 -- 77,460,710(+) gtgcc(A/C/T)gccac intron-variant
rs10148427 -- 77,461,627(+) ACACT(A/C)GTTGA intron-variant
rs1061629 -- 77,459,668(+) TGTTC(C/T)TGGCA reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for AHSA1 Gene

Variant ID Type Subtype PubMed ID
nsv1041985 CNV loss 25217958
nsv832835 CNV gain 17160897

Variation tolerance for AHSA1 Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AHSA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AHSA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AHSA1 Gene

Disorders for AHSA1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AHSA1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
stomatitis
- elite association - COSMIC cancer census association via MalaCards
Search AHSA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AHSA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AHSA1
genes like me logo Genes that share disorders with AHSA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AHSA1 Gene

Publications for AHSA1 Gene

  1. Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone. (PMID: 12604615) Lotz G.P. … Obermann W.M.J. (J. Biol. Chem. 2003) 3 4 22 64
  2. AHSA1 regulates proliferation, apoptosis, migration, and invasion of osteosarcoma. (PMID: 26796264) Shao J. … Li Y. (Biomed. Pharmacother. 2016) 2 3 64
  3. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. (PMID: 27353360) Woodford M.R. … Mollapour M. (Nat. Commun. 2016) 3 4 64
  4. Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia. (PMID: 18556464) Sun F. … Frizzell R.A. (FASEB J. 2008) 3 22 64
  5. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. (PMID: 17110338) Wang X. … Balch W.E. (Cell 2006) 3 22 64

Products for AHSA1 Gene

Sources for AHSA1 Gene

Content
Loading form....