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AHRR Gene

protein-coding   GIFtS: 50
GCID: GC05P000291

Aryl-Hydrocarbon Receptor Repressor

(Previous name: aryl hydrocarbon receptor regulator)
(Previous symbols: AHH, AHHR)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aryl-Hydrocarbon Receptor Repressor1 2     Aryl Hydrocarbon Receptor Regulator1
AHH1 2     Aryl Hydrocarbon Hydroxylase Regulator2
AHHR1 2     Aryl Hydrocarbon Receptor Repressor2
AhR Repressor2 3     Dioxin Receptor Repressor2
Class E Basic Helix-Loop-Helix Protein 772 3     AhRR3
bHLHe772 3     BHLHE773
KIAA12343 5     

External Ids:    HGNC: 3461   Entrez Gene: 574912   Ensembl: ENSG000000634387   OMIM: 6065175   UniProtKB: A9YTQ33   

Export aliases for AHRR gene to outside databases

Previous GC identifers: GC05U990138 GC05P000303 GC02U900446 GC05P000357 GC05P000325 GC05P000327


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AHRR Gene:
The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which
mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a
feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants
encoding different isoforms have been described for this gene. (provided by RefSeq, Jun 2011)

GeneCards Summary for AHRR Gene:
AHRR (aryl-hydrocarbon receptor repressor) is a protein-coding gene. GO annotations related to this gene include protein dimerization activity and signal transducer activity. An important paralog of this gene is ARNT2.

UniProtKB/Swiss-Prot: AHRR_HUMAN, A9YTQ3
Function: Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the
transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT
and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory
region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or
HDAC5. Autoregulates its expression by associating with its own XRE site




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the AHRR gene promoter:
         AhR   MEF-2A   RFX1   POU2F1   NRSF form 1   FOXD3   LUN-1   aMEF-2   CUTL1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAHRR promoter sequence
   Search Chromatin IP Primers for AHRR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AHRR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.3   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15.33

AHRR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AHRR gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P000291:  view genomic region     (about GC identifiers)

Start:
304,291 bp from pter      End:
438,406 bp from pter
Size:
134,116 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AHRR_HUMAN, A9YTQ3 (See protein sequence)
Recommended Name: Aryl hydrocarbon receptor repressor  
Size: 701 amino acids; 76265 Da
Subunit: Interacts with ARNT, ANKRA2, HDAC4 and HDAC5 (By similarity)
Sequence caution: Sequence=ABX89616.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA86548.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7MBN5 D6RAZ1 Q9HAZ3 Q9ULI6
Alternative splicing: 3 isoforms:  A9YTQ3-1   A9YTQ3-2   A9YTQ3-3   

Explore the universe of human proteins at neXtProt for AHRR: NX_A9YTQ3

Explore proteomics data for AHRR at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AHRR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229341.1  NP_065782.2  

    ENSEMBL proteins: 
     ENSP00000424601   ENSP00000323816   ENSP00000424880   ENSP00000430914   ENSP00000428893  
     ENSP00000430842   ENSP00000429944   ENSP00000426932   ENSP00000426076  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    3 InterPro protein domains:
     IPR013767 PAS_fold
     IPR000014 PAS
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry A9YTQ3

    ProtoNet protein and cluster: A9YTQ3

    UniProtKB/Swiss-Prot: AHRR_HUMAN, A9YTQ3
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 PAS (PER-ARNT-SIM) domain


    Find genes that share domains with AHRR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AHRR_HUMAN, A9YTQ3
    Function: Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the
    transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT
    and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory
    region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or
    HDAC5. Autoregulates its expression by associating with its own XRE site
    Induction: By 3-methylcholanthrene (3-MC) in MNCs from adults. By the heterodimer AHR/ARNT

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004871signal transducer activity IEA--
    GO:0046983protein dimerization activity IEA--
         
    Find genes that share ontologies with AHRR           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ahrr):
     homeostasis/metabolism  tumorigenesis 

    Find genes that share phenotypes with AHRR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ahrrtm1Yfk for AHRR

       genOway: Develop your customized and physiologically relevant rodent model for AHRR

    miRNA
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    miRTarBase miRNAs that target AHRR:
    hsa-mir-124-3p (MIRT002644), hsa-mir-18a-5p (MIRT050696), hsa-mir-26a-5p (MIRT050165)

    Block miRNA regulation of human, mouse, rat AHRR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AHRR (see all 19):
    hsa-miR-3685 hsa-miR-125a-5p hsa-miR-106a hsa-miR-488 hsa-miR-374c hsa-miR-124 hsa-miR-125b hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidAHRR 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AHRR_HUMAN, A9YTQ3: Cytoplasm. Nucleus. Note=Predominantly in the nuclear compartment. First cytoplasmic,
    translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    cytosol2
    endosome2
    lysosome1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with AHRR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AHRR About    
    See pathways by source

    SuperPathContained pathways About
    1AhR pathway (WikiPathways)
    AhR pathway
    2AHR Pathway (Qiagen)
    AHR Pathway

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for AHRR
        AHR Pathway

    1 BioSystems Pathway for AHRR
        AhR pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AHRR
    Interactions:

        GeneGlobe Interaction Network for AHRR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AHRR (A9YTQ33 ENSP000003238164) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC4P565243, ENSP000002646064I2D: score=1 STRING: ENSP00000264606
    ANKRA2Q9H9E13, ENSP000002967854I2D: score=1 STRING: ENSP00000296785
    ARNTP275403, ENSP000003514074I2D: score=2 STRING: ENSP00000351407
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    HDAC5Q9UQL63, ENSP000002259834I2D: score=1 STRING: ENSP00000225983
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007165signal transduction ----
    GO:0033235positive regulation of protein sumoylation IEA--

    Find genes that share ontologies with AHRR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AHRR

    1 Novoseek inferred chemical compound relationship for AHRR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ethoxyresorufin 69.5 3 15720127 (1), 17184820 (1), 18502506 (1)



    Find genes that share compounds with AHRR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AHRR gene (2 alternative transcripts): 
    NM_001242412.1  NM_020731.4  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505113 ENST00000316418(uc003jav.3 uc003jaw.3 uc010isy.3 uc010isz.3 uc003jax.3 uc003jay.3 uc003jaz.3)
    ENST00000512529 ENST00000514523 ENST00000510400 ENST00000515206 ENST00000504625
    ENST00000506456 ENST00000510910 ENST00000511487 ENST00000507048
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    Selected qRT-PCR Assays for microRNAs that regulate AHRR (see all 19):
    hsa-miR-3685 hsa-miR-125a-5p hsa-miR-106a hsa-miR-488 hsa-miR-374c hsa-miR-124 hsa-miR-125b hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidAHRR 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat AHRR

    Selected AceView cDNA sequences (see all 202):

    BC012384 BI836980 BQ962370 BI523779 NM_013232 AA973056 CR608684 W79301 
    BU683989 BI822063 BX280586 BC050597 AI982775 CA422285 BP352548 AI984608 
    AA883945 BX280779 BM693810 BC035358 AA825538 AK124302 BX105815 CA397510 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AHRR (see all 20)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9 ^ 10 ^ 11 ^ 12 ^
    SP1:                                                              -     -     -     -     -     -     -     -     -     -     -     -     -     -               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                -                 -           -           -     -           -                                                               
    SP5:                                                  -           -           -     -           -                                                               

    ExUns: 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d · 17e ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b · 23c · 23d
    SP1:  -                 -     -                                                           -                                       
    SP2:                          -                       -                 -                 -                                       
    SP3:                          -                                         -                 -                                       
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for AHRR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AHRR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AHRR Expression
    About this image


    AHRR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    AHRR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AHRR Protein Expression

    UniProtKB/Swiss-Prot: AHRR_HUMAN, A9YTQ3
    Tissue specificity: Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear
    cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus.
    Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach,
    cervix, and ovary

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AHRR gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ahrr1 , 5 aryl-hydrocarbon receptor repressor1, 5 70.5(n)1
    63.33(a)1
      13 (40.15 cM)5
    116241  NM_009644.21  NP_033774.11 
     742111185 
    chicken
    (Gallus gallus)
    Aves AHRR1 aryl-hydrocarbon receptor repressor 56.6(n)
    50.65(a)
      420989  NM_001201387.1  NP_001188316.1 
    lizard
    (Anolis carolinensis)
    Reptilia AHRR6
    aryl-hydrocarbon receptor repressor
    47(a)
    1 ↔ 1
    6(54897246-54925148)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004854881 aryl hydrocarbon receptor repressor-like 53.93(n)
    46.02(a)
      100485488  XM_002935136.2  XP_002935182.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ahrrb6
    aryl-hydrocarbon receptor repressor b
    41(a)
    1 ↔ 1
    2(50703832-50768566) ENSDARG00000052618
    fruit fly
    (Drosophila melanogaster)
    Insecta ss6
    spineless
    17(a)
    1 → many
    3R(12200148-12229412)
    worm
    (Caenorhabditis elegans)
    Secernentea ahr-16
    Protein AHR-1, isoform a (ahr-1) mRNA, complete cd...
    24(a)
    1 → many
    I(9522578-9531130) WBGene00000096


    ENSEMBL Gene Tree for AHRR (if available)
    TreeFam Gene Tree for AHRR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AHRR gene
    ARNT22  CLOCK2  NPAS22  AHR2  ARNT2  EPAS12  NPAS32  HIF1A2  
    SIM22  SIM12  HIF3A2  ARNTL2  NPAS12  ARNTL22  
    3 SIMAP similar genes for AHRR using alignment to 8 protein entries:     AHRR_HUMAN (see all proteins):
    ARNTL    NPAS2    HIF3A

    Find genes that share paralogs with AHRR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    AHRR_HUMAN, A9YTQ3: The Ala-189 allele may be a susceptibility factor for dioxin-related male infertility. Homozygosity
    for Ala-189 is observed in azoospermic individuals at higher frequency than in normozoospermic individuals. Might
    also be associated with susceptibility to and severity of endometriosis


    Selected SNPs for AHRR (see all 3239)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1498205031,2
    --287909(+) GAGGGC/TGGGTC 2 -- us2k10--------
    rs766234151,2
    C--314145(+) CCTGCTGTGTC  
      CTGA
    /-
    GCTGC
    2 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs15679561,2
    C,F,A--315616(-) AACTGG/TGTGGA 2 -- int18Minor allele frequency- T:0.16NA PA WA 496
    rs2015337351,2
    --315659(+) TGGGA-/TCTTCTGT 2 -- cds10--------
    rs111339691,2
    C--315660(+) GGGATCTTC    
       TAC
    /-
    CTGTT
    2 -- int11Minor allele frequency- -:0.50CSA 2
    rs39756661,2
    C--315662(+) GATCT-/TC    
       TACCT
    GTTCA
    2 -- int10--------
    rs560613261,2
    C,F--315678(+) CTGCTC/TGGTGT 2 -- int12Minor allele frequency- T:0.07WA 120
    rs131631181,2
    C--315679(+) TGCTCG/AGTGTG 2 -- int18Minor allele frequency- A:0.32NA WA EA 368
    rs1400339291,2
    --315709(+) GAGCAC/TGGTTT 2 -- int10--------
    rs1998958831,2
    C--315759(+) GCTGT-/GGGGGG 2 -- int10--------

    HapMap Linkage Disequilibrium report for AHRR (304291 - 438406 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AHRR (see all 56):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2369327CNV Deletion18987734
    esv1500777CNV Deletion17803354
    esv2094113CNV Deletion18987734
    esv2674163CNV Deletion23128226
    esv2095296CNV Deletion18987734
    esv2231288CNV Deletion18987734
    esv995455CNV Deletion20482838
    esv1997829CNV Deletion18987734
    esv2581256CNV Deletion19546169
    nsv327676CNV Insertion16902084

    Human Gene Mutation Database (HGMD): AHRR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AHRR
    DNA2.0 Custom Variant and Variant Library Synthesis for AHRR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606517    OMIM disorders: --


    Find genes that share disorders with AHRR           About GenesLikeMe

    5 Novoseek inferred disease relationships for AHRR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ahh inducibility 96.4 14 1811685 (3), 7550366 (1), 2070496 (1)
    cancer lung 51.1 18 8162876 (7), 2070496 (2), 12777964 (2), 2134687 (1) (see all 6)
    liver diseases 21.9 2 2040107 (2)
    tumors 0 3 8162876 (2)
    cancer 0 9 8162876 (4), 1811685 (2)

    Genetic Association Database (GAD): AHRR
    Human Genome Epidemiology (HuGE) Navigator: AHRR (662 documents)

    Export disorders for AHRR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AHRR gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with AHRR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility. (PubMed id 17559847)1, 2, 4 Merisalu A....Salumets A. (Fertil. Steril. 2007)
    2. Characterization of the aryl hydrocarbon receptor repressor gene and association of its Pro185Ala polymorphism with micropenis. (PubMed id 11835227)1, 2, 4 Fujita H.... Kosaki K. (Teratology 2002)
    3. Characteristic expression of aryl hydrocarbon receptor repressor gene in human tissues: organ-specific distribution and variable induction patterns in mononuclear cells. (PubMed id 14672759)1, 2, 9 Yamamoto J.... Hara T. (Life Sci. 2004)
    4. Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2. (PubMed id 21602797)1, 4 Wright F.A....Cutting G.R. (Nat. Genet. 2011)
    5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    6. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (Hum. Reprod. 2010)
    7. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    8. Association between patient age at the time of surgical treatment for endometriosis and aryl hydrocarbon receptor repressor polymorphism. (PubMed id 19501819)1, 4 Asada H....Yoshimura Y. (Fertil. Steril. 2009)
    9. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    10. The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers. (PubMed id 18172554)1, 2 Zudaire E....Cuttitta F. (J. Clin. Invest. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57491 HGNC: 346 AceView: PDCD6 Ensembl:ENSG00000063438 euGenes: HUgn57491
    ECgene: AHRR H-InvDB: AHRR

    (According to HUGE)
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    HUGE: KIAA1234

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AHRR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AHRR gene:
    Search GeneIP for patents involving AHRR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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