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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AHRR Gene

protein-coding GIFtS: 49
GCID: GC05P000291

aryl-hydrocarbon receptor repressor

(Previous name: aryl hydrocarbon receptor regulator )
(Previous symbols: AHH, AHHR)

Explore 24 diseases affiliated with
AHRR via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Aryl-Hydrocarbon Receptor Repressor¹ ²		Aryl Hydrocarbon Receptor Regulator¹
BHLHe77¹		Aryl Hydrocarbon Hydroxylase Regulator²
KIAA1234¹ ³ ⁵		Aryl Hydrocarbon Receptor Repressor²
AHH¹ ²		Dioxin Receptor Repressor²
AHHR¹ ²		AhRR³
AhR Repressor² ³		BHLHE77³
Class E Basic Helix-Loop-Helix Protein 77² ³

External Ids:	HGNC: 346¹	Entrez Gene: 57491²	Ensembl: ENSG00000063438⁷	OMIM: 606517⁵	UniProtKB: A9YTQ3³

Export aliases for AHRR gene to outside databases

Previous GC identifers: GC05U990138 GC05P000303 GC02U900446 GC05P000357 GC05P000325 GC05P000327

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AHRR:

The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates

dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback

modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different

isoforms have been described for this gene. (provided by RefSeq, Jun 2011)

UniProtKB/Swiss-Prot: AHRR_HUMAN, A9YTQ3

Function: Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the

transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and

subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of

variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5.

Autoregulates its expression by associating with its own XRE site

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AHRR gene promoter:
AhR MEF-2A RFX1 POU2F1 NRSF form 1 FOXD3 LUN-1 aMEF-2 CUTL1 NRSF form 2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AHRR promoter sequence

Search SABiosciences Chromatin IP Primers for AHRR

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AHRR

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.3 Ensembl cytogenetic band: 5p15.33 HGNC cytogenetic band: 5p15.33

AHRR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AHRR gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P000291: view genomic region (about GC identifiers)

Start:	304,291 bp from pter	End:	438,406 bp from pter
Size:	134,116 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AHRR_HUMAN, A9YTQ3 (See protein sequence)

Recommended Name: Aryl hydrocarbon receptor repressor

Size: 701 amino acids; 76265 Da

Subunit: Interacts with ARNT, ANKRA2, HDAC4 and HDAC5 (By similarity)

Subcellular location: Cytoplasm. Nucleus. Note=Predominantly in the nuclear compartment. First cytoplasmic,

translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment

Sequence caution: Sequence=ABX89616.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAA86548.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: A7MBN5 D6RAZ1 Q9HAZ3 Q9ULI6

Alternative splicing: 3 isoforms: A9YTQ3-1 A9YTQ3-2 A9YTQ3-3

Explore the universe of human proteins at neXtProt for AHRR: NX_A9YTQ3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_A9YTQ3

AHRR Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001229341.1 NP_065782.2

ENSEMBL proteins:

ENSP00000424601 ENSP00000323816 ENSP00000424880 ENSP00000430914 ENSP00000428893

ENSP00000430842 ENSP00000429944 ENSP00000426932 ENSP00000426076

Human Recombinant Protein Products:

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	Novus Biologicals AHRR Protein
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for AHRR

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

AHRR for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for AHRR

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AHRR for domains About GeneDecksing

3 InterPro domains/families:

IPR013767 PAS_fold

IPR000014 PAS

IPR011598 HLH_dom

Graphical View of Domain Structure for InterPro Entry A9YTQ3

ProtoNet protein and cluster: A9YTQ3

UniProtKB/Swiss-Prot: AHRR_HUMAN, A9YTQ3

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: AHRR_HUMAN, A9YTQ3

Function: Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the

transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and

subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of

variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5.

Autoregulates its expression by associating with its own XRE site

Induction: By 3-methylcholanthrene (3-MC) in MNCs from adults. By the heterodimer AHR/ARNT

miRNA Products:		OriGene 3'-UTR Clone: AHRR Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AHRR
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate AHRR (see all 19):
		hsa-miR-3685 hsa-miR-125a-5p hsa-miR-106a hsa-miR-488 hsa-miR-374c hsa-miR-124 hsa-miR-125b hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: AHRR 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AHRR (see all 7) OriGene shRNA RFP: AHRR OriGene siRNA: AHRR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AHRR

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for AHRR

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		GenScript: all cDNA clones in your preferred vector: AHRR (NM_020731)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for AHRR
		Search LifeMap BioReagents cell lines for AHRR

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHRR

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0004871	signal transducer activity	IEA	--
GO:0046983	protein dimerization activity	IEA	--

AHRR for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Ahrr^tm1Yfk for AHRR
     2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ahrr):

homeostasis/metabolism

tumorigenesis

AHRR for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

AHR Pathway

AHR Pathway

1.00

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AHRR

AHR Pathway

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for AHRR

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/36 Interacting proteins for AHRR (A9YTQ3³ ENSP00000323816⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HDAC4	P56524³, ENSP00000264606⁴	I2D: score=1 STRING: ENSP00000264606
ANKRA2	Q9H9E1³, ENSP00000296785⁴	I2D: score=1 STRING: ENSP00000296785
ARNT	P27540³, ENSP00000351407⁴	I2D: score=2 STRING: ENSP00000351407
ESR1	P03372³, ENSP00000206249⁴	I2D: score=1 STRING: ENSP00000206249
HDAC5	Q9UQL6³, ENSP00000225983⁴	I2D: score=1 STRING: ENSP00000225983

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0033235	positive regulation of protein sumoylation	IEA	--
GO:0045892	negative regulation of transcription, DNA-dependent	--	--

AHRR for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

AHRR for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AHRR
1 Novoseek chemical compound relationship for AHRR gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ethoxyresorufin	69.5	3	15720127 (1), 17184820 (1), 18502506 (1)

Search CenterWatch for drugs/clinical trials and news about AHRR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AHRR gene (2 alternative transcripts):

NM_001242412.1 NM_020731.4

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000505113 ENST00000316418(uc003jav.3 uc003jaw.3 uc010isy.3 uc010isz.3 uc003jax.3 uc003jay.3 uc003jaz.3)

ENST00000512529 ENST00000514523 ENST00000510400 ENST00000515206 ENST00000504625

ENST00000506456 ENST00000510910 ENST00000511487 ENST00000507048

miRNA Products:		OriGene 3'-UTR Clone: AHRR Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AHRR
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate AHRR (see all 19):
		hsa-miR-3685 hsa-miR-125a-5p hsa-miR-106a hsa-miR-488 hsa-miR-374c hsa-miR-124 hsa-miR-125b hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: AHRR 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AHRR (see all 7) OriGene shRNA RFP: AHRR OriGene siRNA: AHRR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AHRR

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AHRR (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AHRR OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: AHRR (NM_020731)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for AHRR
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHRR

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AHRR Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AHRR
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AHRR

24/202 AceView cDNA sequences (see all 202):

BG654353 AA973056 AI469550 BM820499 BI764882 T34498 NM_013232 AJ707581

BI836980 BQ962370 AA825538 CA422285 BI523779 BC012384 BG166879 W79301

BU193271 CR592133 BG393640 BM723201 BI822063 BU683989 AI522238 BC050597

GeneLoc Exon Structure

5/20 Alternative Splicing Database (ASD) splice patterns (SP) for AHRR (see all 20) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	·	8e	·	8f	^	9	^	10	^	11	^	12	^
SP1:																					-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP2:
SP3:
SP4:											-						-				-				-		-				-
SP5:																	-				-				-		-				-

ExUns:	13	^	14	^	15	^	16	^	17a	·	17b	·	17c	·	17d	·	17e	^	18a	·	18b	^	19	^	20a	·	20b	^	21a	·	21b	^	22	^	23a	·	23b	·	23c	·	23d
SP1:	-						-		-																				-
SP2:									-								-						-						-
SP3:									-														-						-
SP4:
SP5:

ECgene alternative splicing isoforms for AHRR

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AHRR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

AHRR expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Mandibular Process

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See AHRR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AHRR

UniProtKB/Swiss-Prot: AHRR_HUMAN, A9YTQ3

Tissue specificity: Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells

(MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated

malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary

SABiosciences Custom PCR Arrays for AHRR

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AHRR

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHRR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for AHRR gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ahrr^{1 , 5}	aryl-hydrocarbon receptor repressor^{1, 5}	71.41(n)¹ 64.39(a)¹		13 (40.15 cM)⁵ 11624¹ NM_009644.2¹ NP_033774.1¹ 74211118⁵
chicken (Gallus gallus)	Aves	AHRR¹	aryl-hydrocarbon receptor repressor	56.87(n) 50.51(a)		420989 NM_001201387.1 NP_001188316.1
lizard (Anolis carolinensis)	Reptilia	AHRR⁶	--	47(a)	1 ↔ 1	6(54897246-54925148)
zebrafish (Danio rerio)	Actinopterygii	ahrrb⁶	aryl-hydrocarbon receptor repressor b	34(a)	1 ↔ 1	2(50703832-50768566)
fruit fly (Drosophila melanogaster)	Insecta	ss⁶	spineless	14(a)	1 → many	3R(12200148-12229412)
worm (Caenorhabditis elegans)	Secernentea	ahr-1⁶	Aryl hydrocarbon receptor protein 1	21(a)	1 → many	I(9522570-9531122)

ENSEMBL Gene Tree for AHRR (if available)
TreeFam Gene Tree for AHRR (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for AHRR gene

AHR²

3 SIMAP similar genes for AHRR using alignment to 8 protein entries: AHRR_HUMAN (see all proteins):

ARNTL NPAS2 HIF3A

AHRR for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: AHRR_HUMAN, A9YTQ3

Polymorphism: The Ala-189 allele may be a susceptibility factor for dioxin-related male infertility. Homozygosity for

Ala-189 is observed in azoospermic individuals at higher frequency than in normozoospermic individuals. Might also be

associated with susceptibility to and severity of endometriosis

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1567956^1,2	C,A,	--	315616(-)	`AACTGG/TGTGGA`	2	--	int¹		8		NA PA WA	496
rs201533735^1,2		--	315659(+)	`TGGGA-/TCTTCTGT`	2	--	int¹		0	--	--	--	--
rs11133969^1,2	C,	--	315660(+)	`GGGATCTTC TAC/-CTGTT`	2	--	int¹		1		CSA	2
rs56061326^1,2	C,	--	315678(+)	`CTGCTC/TGGTGT`	2	--	int¹		2		WA	120
rs13163118^1,2	C,	--	315679(+)	`TGCTCG/AGTGTG`	2	--	int¹		8		NA WA EA	368
rs140033929^1,2		--	315709(+)	`GAGCAC/TGGTTT`	2	--	int¹		0	--	--	--	--
rs199895883^1,2		--	315759(+)	`GCTGT-/GGGGGG`	2	--	int¹		0	--	--	--	--
rs190922254^1,2		--	315870(+)	`ACTCCA/CGGCTC`	2	--	int¹		0	--	--	--	--
rs35701650^1,2	C,	--	315982(+)	`ATCCAC/GGCCGG`	2	--	int¹		2		WA	120
rs183295836^1,2		--	315992(+)	`GGTGCC/TTCCCT`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for AHRR (304291 - 438406 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 30 variations for AHRR
15/16 CNVs (see all 16): 80754 3536 80757 68926 8476 51710 8470 32690 92785 4228 51709 68927 4427 92782 36414
14 Indels: 68928 92784 46884 46888 46893 80755 92783 92788 80756 99029 12633 92787 46879 92786
Human Gene Mutation Database (HGMD): AHRR

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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AHRR for disorders           About GeneDecksing

OMIM gene information: 606517    OMIM disorders: --

20/24 diseases for AHRR (see all 24):    About MalaCards

dysgammaglobulinemia esophageal squamous cell carcinoma micropenis squamous cell carcinoma

ovarian cystadenoma male infertility liver disease cystadenoma

cystic fibrosis laryngitis infertility azoospermia

laryngeal cancer lung cancer hepatitis b pulmonary disease

fibrosis esophagitis endometriosis hepatitis

5 Novoseek disease relationships for AHRR gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ahh inducibility	96.4	14	1811685 (3), 7550366 (1), 2070496 (1)
cancer lung	51.1	18	8162876 (7), 2070496 (2), 12777964 (2), 2134687 (1) (see all 6)
liver diseases	21.9	2	2040107 (2)
tumors	0	3	8162876 (2)
cancer	0	9	8162876 (4), 1811685 (2)

Genetic Association Database (GAD): AHRR
Human Genome Epidemiology (HuGE) Navigator: AHRR (662 documents)

Export disorders for AHRR gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for AHRR gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with AHRR)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of the aryl hydrocarbon receptor repressor gene and association of its Pro185Ala polymorphism with micropenis. (PubMed id 11835227)^{1, 2, 4} Fujita H.... Kosaki K. (2002)
Characteristic expression of aryl hydrocarbon receptor repressor gene in human tissues: organ-specific distribution and variable induction patterns in mononuclear cells. (PubMed id 14672759)^{1, 2, 9} Yamamoto J.... Hara T. (2004)
The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers. (PubMed id 18172554)^{1, 2} Zudaire E....Cuttitta F. (2008)
Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines. (PubMed id 17890447)^{1, 2} Haarmann-Stemmann T....Fritsche E. (2007)
Identification of intracellular localization signals and of mechanisms underlining the nucleocytoplasmic shuttling of human aryl hydrocarbon receptor repressor. (PubMed id 17980155)^{1, 2} Kanno Y.... Inouye Y. (2007)
The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility. (PubMed id 17559847)^{1, 2} Merisalu A....Salumets A. (2007)
Analysis of the AhR, ARNT, and AhRR gene polymorphisms: genetic contribution to endometriosis susceptibility and severity. (PubMed id 16084889)^{1, 2} Tsuchiya M.... Ikenoue T. (2005)
Association of male infertility with Pro185Ala polymorphism in the aryl hydrocarbon receptor repressor gene: implication for the susceptibility to dioxins. (PubMed id 15474075)^{1, 2} Watanabe M....Ogata T. (2004)
Structure and expression of the Ah receptor repressor gene. (PubMed id 11423533)^{1, 3} Baba T....Fujii-Kuriyama Y. (2001)
Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{1, 2} Nagase T.... Ohara O. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57491	HGNC: 346	AceView: PDCD6	Ensembl:ENSG00000063438	euGenes: HUgn57491
ECgene: AHRR	H-InvDB: AHRR

(According to HUGE)
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HUGE: KIAA1234

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for AHRR	Pharmacogenomics, SNPs, Pathways

Intellectual Property for AHRR gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for AHRR gene:
Search GeneIP for patents involving AHRR

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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