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AHRR Gene

protein-coding GIFtS: 53

GC05P000327

aryl-hydrocarbon receptor repressor
(Previous name: aryl hydrocarbon receptor regulator )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: AHH, AHHR)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AHH ^²
AHHR ^²
AhRR ^³
BHLHE77 ^³
KIAA1234 ^¹, ², ³, ⁵
MGC167813 ^²
MGC176630 ^²
bHLHe77 ^¹, ², ³

Descriptions
AhR repressor ^³
Class E basic helix-loop-helix protein 77 ^³
aryl hydrocarbon hydroxylase regulator ^²
aryl hydrocarbon receptor regulator ^¹, ²
aryl-hydrocarbon receptor repressor ^²
arylhydrocarbon receptor repressor ^²
dioxin receptor repressor ^²

External Ids
HGNC: 346¹
Entrez Gene: 57491²
UniProtKB: A9YTQ3³
Ensembl: ENSG00000063438⁷

Search outside databases for aliases for AHRR gene

Previous GC identifers: GC05U990138 GC05P000303 GC02U900446 GC05P000357 GC05P000325

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AHRR:

Dioxin is a teratogen that exerts its effects through the arylhydrocarbon receptor in conjunction

with the receptor's binding partner, arylhydrocarbon receptor nuclear translocator. The

protein encoded by this gene represses signal transduction by the arylhydrocarbon receptor by

competing with the arylhydrocarbon receptor nuclear translocator for binding to the

arylhydrocarbon receptor. Expression of the repressor is stimulated by the receptor/translocator

heterodimer, thereby regulating receptor function through a negative feedback mechanism. In

addition, the encoded protein can bind to nuclear factor kappa-B. [provided by RefSeq]

UniProtKB/Swiss-Prot: AHRR_HUMAN, A9YTQ3

Function: Mediates dioxin toxicity and is involved in regulation of cell growth and

differentiation. Represses the transcription activity of AHR by competing with this transcription

factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response

element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses

CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its

expression by associating with its own XRE site

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AHRR gene

Entrez Gene cytogenetic band: 5p15.3 Ensembl cytogenetic band: 5p15.33 HGNC cytogenetic band: 5p15.33

AHRR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P000327: (about GC identifiers)

Start:	324,736 bp from pter
End:	491,406 bp from pter
Size:	166,671 bases
Orientation:	plus strand

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AHRR_HUMAN, A9YTQ3 (See protein sequence)

Recommended Name: Aryl hydrocarbon receptor repressor

Size: 701 amino acids; 76239 Da

Subunit: Interacts with ARNT, ANKRA2, HDAC4 and HDAC5 (By similarity)

Subcellular location: Cytoplasm. Nucleus. Note=Predominantly in the nuclear compartment. First

cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the

cytoplasmic compartment

Secondary accessions: A7MBN5 Q9HAZ3 Q9ULI6

Alternative splicing: 3 isoforms: A9YTQ3-1 A9YTQ3-2 A9YTQ3-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_065782.2

ENSEMBL proteins:

ENSP00000323816 ENSP00000264933

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (AHRR)
	Human Recombinant Proteins from Abnova (AHRR)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for AHRR:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for AHRR
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (AHRR), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AHRR)
	Novus Biologicals Antibody for AHRR

Assays for AHRR:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry A9YTQ3

ProtoNet protein and cluster: A9YTQ3

UniProtKB/Swiss-Prot: AHRR_HUMAN, A9YTQ3

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AHRR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AHRR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020731

Applied Biosystems Silencer® siRNAs for AHRR

Sigma-Aldrich siRNA for AHRR

Sigma-Aldrich shRNA Panels and shRNA for AHRR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_020731
Myc/DDK tagged cDNA clone in CMV expression vector: NM_020731
untagged cDNA clones in CMV expression vector (see all 2): NM_020731

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_020731

UniProtKB/Swiss-Prot: AHRR_HUMAN, A9YTQ3

Function: Mediates dioxin toxicity and is involved in regulation of cell growth and

differentiation. Represses the transcription activity of AHR by competing with this transcription

factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response

element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses

CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its

expression by associating with its own XRE site

Induction: By 3-methylcholanthrene (3-MC) in MNCs from adults. By the heterodimer AHR/ARNT

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ahrr):

tumorigenesis

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for AHRR (Your Favorite Gene powered by Ingenuity)

Aryl Hydrocarbon Receptor Signaling
Xenobiotic Metabolism Signaling

GeneDecks AHRR for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for AHRR

5/12 Interacting proteins for AHRR (ENSP00000323816³) via UniProtKB, MINT, and/or STRING (see all 12 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PDCD6IP	ENSP00000307387³	STRING (score=.997)
PEF1	ENSP00000362807³	STRING (score=.993)
ABI2	ENSP00000295851³	STRING (score=.949)
PLSCR3	ENSP00000316021³	STRING (score=.925)
CYP1A1	ENSP00000369050³	STRING (score=.861)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AHRR
1 Novoseek chemical compound relationship for AHRR gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ethoxyresorufin	69.89	3	15720127 (1), 17184820 (1), 18502506 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AHRR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AHRR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020731

Sigma-Aldrich siRNA for AHRR

Sigma-Aldrich shRNA Panels and shRNA for AHRR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_020731

REFSEQ mRNAs for AHRR gene:

NM_020731.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_020731

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020731
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_020731
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_020731

24/202 AceView cDNA sequences (see all 202 ):

CR608684 CB529916 BG654353 BX401012 BM693810 BU508015 BP352548 AA973056

BI822063 AI982775 BG655707 BX280779 BG166879 BU683989 AA825538 CR592133

AI469550 AW439592 AI984608 T34498 BM723201 AA883945 BX105815 BU193271

highest scoring ESTs for AHRR:

AI472048 AI279974 AK127977 AL134427 AW573306 BC035358 BM682431 W93502 AA098916 AA883945

GeneLoc Exon Structure

5/20 Alternative Splicing Database (ASD) splice patterns (SP) for AHRR (see all 20 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	·	8e	·	8f	^	9	^	10	^	11	^	12	^
SP1:																					-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP2:
SP3:
SP4:											-						-				-				-		-				-
SP5:																	-				-				-		-				-

ExUns:	13	^	14	^	15	^	16	^	17a	·	17b	·	17c	·	17d	·	17e	^	18a	·	18b	^	19	^	20a	·	20b	^	21a	·	21b	^	22	^	23a	·	23b	·	23c	·	23d
SP1:	-						-		-																				-
SP2:									-								-						-						-
SP3:									-														-						-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for AHRR

2 Ensembl transcripts including schematic representations:

ENST00000316418 ENST00000264933

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AHRR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AHRR

¹ / ² / ³

5 probe-sets matching AHRR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
85315_at²^{, 3}	U95-D	1	1.00	1.00	0.02	1.12	AI472048	0.80	0.70	0.75	1
49314_at²^{, 3}	U95-B	1	1.00	1.00	0.86	0.62	W93502	0.60	0.62	0.61	1
88658_at²^{, 3}	U95-E	1	0.94	1.00	0.19	1.36	AI693739	0.40	0.50	0.45	1
229354_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AB033060	0.40	0.50	0.45	1
229354_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks AHRR for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --
UniProtKB/Swiss-Prot: AHRR_HUMAN, A9YTQ3
Tissue specificity: Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed
in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung,
kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins,
including colon, breast, lung, stomach, cervix, and ovary

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AHRR gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	AHRR¹	--	aryl-hydrocarbon receptor repressor	73.78(n) 65.76(a)	529500 XM_001256322.1 XP_001256323.1
rat (Rattus norvegicus)	Ahrr¹	--	aryl-hydrocarbon receptor repressor	70.86(n) 63.7(a)	498999 NM_001024285.1 NP_001019456.1
mouse (Mus musculus)	Ahrr^{1, 5}	13⁵	aryl-hydrocarbon receptor repressor^{1, 5}	71.41(n)¹ 64.39(a)¹	11624¹ NM_009644.2¹ NP_033774.1¹ AB015140⁵ AB062923⁵ (see all 12)
baker's yeast (Saccharomyces cerevisiae)	PEF1(YGR058W)⁴	7(606140-607147)	Penta-EF-hand protein required for polar bud growth more	--	852949 NP_011572.1

About this table Species with no ortholog for AHRR

ENSEMBL Gene Tree for AHRR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AHRR gene

AHR²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: AHRR_HUMAN, A9YTQ3

Polymorphism: The Ala-189 allele may be a susceptibility factor for dioxin-related male

infertility. Homozygosity for Ala-189 is observed in azoospermic individuals at higher frequency

than in normozoospermic individuals. Might also be associated with susceptibility to and severity

of endometriosis

10/971 NCBI SNPs in AHRR are shown (see all 971 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 276)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2241599^1,2	A,C,F,H,O	491454(-)	`CTCTTT/AAAAGG`	1	--	ng3¹		5	EA EU WA	1888
	rs10078^1,2	A,C,F,H,O	491102(-)	`ACATAA/CACAGA`	1	--	ut3¹		13	MN EU EA WA NA CSAM	1380
	rs2672725^1,2	A,C,F,H,O	487981(+)	`TCTGTC/GTGTCT`	1	--	ut3¹ ese³		5	EA EU WA	1908
	rs349583^1,2	A,C,F,H,O	489665(-)	`TTCTCC/TTCCAG`	1	--	ut3¹		4	EU EA WA	410
	rs2561659^1,2	A,C,F,H,O	488560(-)	`GGAACG/ATTCTA`	1	--	ut3¹		5	EA EU WA	1912
	rs2672779^1,2	A,C,F,H	488055(+)	`CACACG/TCTTTG`	1	--	ut3¹ ese³		4	EU EA WA	412
	rs1058337^1,2	A,C,F,H	488021(+)	`CCTGCT/GCCTGG`	1	--	ut3¹ ese³		8	MN NA EU EA WA	631
	rs2241598^1,2	A,C,F,H	491564(-)	`CAGGCG/ATTTTC`	1	--	ng3¹		9	EA EU WA	1726
	rs2292596^1,2	C,F,H	475955(-)	`CGGGGG/CCTGCC`	1	A/P	mis¹ ese³		11	EA MN CSAM NA EU WA	2374
	rs2303738^1,2	C,F,H	486056(-)	`CTGAGC/ACCCCC`	1	V/G	mis¹ ese³		6	EA EU WA NA	1982

About this table

HapMap Linkage Disequilibrium images for AHRR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606517

5 Novoseek disease relationships for AHRR gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ahh inducibility	96.37	14	1811685 (3), 7550366 (1), 2070496 (1)
cancer lung	52.26	18	8162876 (7), 2070496 (2), 12777964 (2), 2134687 (1) (see all 6)
liver diseases	23.31	2	2040107 (2)
cancer	0.00	9	8162876 (4), 1811685 (2)
tumors	0.00	3	8162876 (2)

About this table

Human Gene Mutation Database: AHRR
Genetic Association Database: AHRR
Human Genome Epidemiology Navigator: AHRR (510 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/40 PubMed articles for AHRR gene (see all 40 ):

Characterization of the aryl hydrocarbon receptor repressor gene and association of its Pro185Ala polymorphism with micropenis. (PubMed id 11835227)^{3, 4, 6} Fujita H....Kosaki K. (2002)
Characteristic expression of aryl hydrocarbon receptor repressor gene in human tissues: organ-specific distribution and variable induction patterns in mononuclear cells. (PubMed id 14672759)^{1, 3, 4} Yamamoto J....Hara T. (2004)
The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers. (PubMed id 18172554)^{3, 4} Zudaire E....Cuttitta F. (2008)
Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines. (PubMed id 17890447)^{3, 4} Haarmann-Stemmann T....Fritsche E. (2007)
Identification of intracellular localization signals and of mechanisms underlining the nucleocytoplasmic shuttling of human aryl hydrocarbon receptor repressor. (PubMed id 17980155)^{3, 4} Kanno Y.... Inouye Y. (2007)
The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility. (PubMed id 17559847)^{3, 4} Merisalu A....Salumets A. (2007)
Analysis of the AhR, ARNT, and AhRR gene polymorphisms: genetic contribution to endometriosis susceptibility and severity. (PubMed id 16084889)^{3, 4} Tsuchiya M.... Ikenoue T. (2005)
Association of male infertility with Pro185Ala polymorphism in the aryl hydrocarbon receptor repressor gene: implication for the susceptibility to dioxins. (PubMed id 15474075)^{3, 4} Watanabe M....Ogata T. (2004)
Structure and expression of the Ah receptor repressor gene. (PubMed id 11423533)^{2, 3} Baba T....Fujii-Kuriyama Y. (2001)
Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{3, 4} Nagase T....Ohara O. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 57491	HGNC: 346	AceView: PDCD6	Ensembl:ENSG00000063438	euGenes: HUgn57491
ECgene: AHRR	H-InvDB: AHRR

(According to HUGE)
About This Section

HUGE: KIAA1234

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for AHRR
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for AHRR:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AHRR-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AHRR		Antibodies for AHRR
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AHRR		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Antibodies for AHRR

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AHRR Gene

protein-coding GIFtS: 53

Aliases &
Descriptions
for AHRR

Summaries
for AHRR

Genomic Location
for AHRR

Proteins
for AHRR

Protein Domains/
Families
for AHRR

Gene Function
for AHRR

Pathways & Interactions
for AHRR

Drugs & Compounds
for AHRR

Transcripts
for AHRR

Expression
for AHRR

Orthologs
for AHRR

Paralogs
for AHRR

SNPs/Variants
for AHRR

Disorders & Mutations
for AHRR

Medical News
for AHRR

Publications
for AHRR

Search for AHRR

Genome Databases showing AHRR

Other Databases showing AHRR

Specialized Databases showing AHRR

Licensable Technologies
for AHRR

Services
for AHRR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AHRR Gene

protein-coding GIFtS: 53

Aliases & Descriptionsfor AHRR

Summariesfor AHRR

Genomic Locationfor AHRR

Proteinsfor AHRR

Protein Domains/Familiesfor AHRR

Gene Functionfor AHRR

Pathways & Interactionsfor AHRR

Drugs & Compoundsfor AHRR

Transcriptsfor AHRR

Expression for AHRR

Orthologsfor AHRR

Paralogsfor AHRR

SNPs/Variantsfor AHRR

Disorders & Mutationsfor AHRR

Medical Newsfor AHRR

Publicationsfor AHRR

Search for AHRR

Genome Databases showing AHRR

Other Databases showing AHRR

Specialized Databases showing AHRR

Licensable Technologiesfor AHRR

Servicesfor AHRR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AHRR

Summaries
for AHRR

Genomic Location
for AHRR

Proteins
for AHRR

Protein Domains/
Families
for AHRR

Gene Function
for AHRR

Pathways & Interactions
for AHRR

Drugs & Compounds
for AHRR

Transcripts
for AHRR

Expression
for AHRR

Orthologs
for AHRR

Paralogs
for AHRR

SNPs/Variants
for AHRR

Disorders & Mutations
for AHRR

Medical News
for AHRR

Publications
for AHRR

Licensable Technologies
for AHRR

Services
for AHRR