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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AHR Gene

protein-coding GIFtS: 67
GCID: GC07P017304

aryl hydrocarbon receptor

Explore 90 diseases affiliated with
AHR via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Aryl Hydrocarbon Receptor¹ ²		AH-Receptor¹
BHLHe76¹		Aromatic Hydrocarbon Receptor²
Ah Receptor² ³		AhR³
Class E Basic Helix-Loop-Helix Protein 76² ³		BHLHE76³

External Ids:	HGNC: 348¹	Entrez Gene: 196²	Ensembl: ENSG00000106546⁷	OMIM: 600253⁵	UniProtKB: P35869³

Export aliases for AHR gene to outside databases

Previous GC identifers: GC07P016982 GC07P017082 GC07P017111 GC07P017224

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AHR:

This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar

aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome

P450. Its ligands included a variety of aromatic hydrocarbons. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AHR_HUMAN, P35869

Function: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates

the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene).

Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely

to play an important role in the development and maturation of many tissues

summary for AHR:

Aryl hydrocarbon receptors (AHRs) are cytosolic transcription factors that exist bound to co-chaperones in

the resting state (Hsp90, prostaglandin E synthase 3 and hepatitis B virus X-associated protein 2). Ligand

binding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize with

AHR nuclear translocator (ARNT) and alter transcription of target genes. AHR is an evolutionary conserved

receptor that has roles in cell proliferation and differentiation and induction of xenobiotic-metabolizing

enzymes (for example CYP1A1). The human gene encoding the aryl hydrocarbon receptor has been localized to

chromosome 7p15.

Gene Wiki entry for AHR (Aryl hydrocarbon receptor)

PharmGKB "VIP" summary for AHR

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AHR gene promoter:
GR Max1 Sp1 HNF-3beta PPAR-gamma1 PPAR-gamma2 GR-alpha c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): AHR promoter sequence

Search SABiosciences Chromatin IP Primers for AHR

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AHR

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15 Ensembl cytogenetic band: 7p21.1 HGNC cytogenetic band: 7p15

AHR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AHR gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P017304: view genomic region (about GC identifiers)

Start:	17,338,246 bp from pter	End:	17,385,776 bp from pter
Size:	47,531 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 17,391,672-17,439,185

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AHR_HUMAN, P35869 (See protein sequence)

Recommended Name: Aryl hydrocarbon receptor precursor

Size: 848 amino acids; 96147 Da

Subunit: Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. In the

nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the

corepressor SMRT. Interacts with NEDD8 and IVNS1ABP

Subcellular location: Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a

HSP90, it translocates to the nucleus

Secondary accessions: A4D130 Q13728 Q13803 Q13804

Explore the universe of human proteins at neXtProt for AHR: NX_P35869

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P35869

AHR Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001612.1

ENSEMBL proteins:

ENSP00000242057 ENSP00000436466

Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for AHR

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005667	transcription factor complex	TAS	19538249
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	--	--

AHR for ontologies About GeneDecksing

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	Uscn Antibodies for AHR
	ThermoFisher Antibody for AHR

Assay Products for AHR:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for AHR
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for AHR

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AHR for domains About GeneDecksing

5 InterPro domains/families:

IPR001610 PAC

IPR013767 PAS_fold

IPR000014 PAS

IPR011598 HLH_dom

IPR013655 PAS_fold_3

Graphical View of Domain Structure for InterPro Entry P35869

ProtoNet protein and cluster: P35869

3 Blocks protein families:

IPB001092 Basic helix-loop-helix dimerization domain bHLH

IPB001610 PAC motif

IPB013655 PAS fold-3

UniProtKB/Swiss-Prot: AHR_HUMAN, P35869

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: AHR_HUMAN, P35869

Function: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates

the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene).

Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely

to play an important role in the development and maturation of many tissues

Induction: Induced or repressed by TGFB1 and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic acid,

and 12-O-tetradecanoyl phorbol-13 acetate (TPA)

Genatlas biochemistry entry for AHR:

aryl hydrocarbon receptor,unliganded,retained in cytoplasm in resting state in association with HSP90,and with AIP (AH

receptor associated protein 9),released after exposure to xenobiotics,dimerizing with ARNT and translocated to the

nucleus interacting with pRB1 to induce G1 arrest

		10/960 SABiosciences Target genes for AHR (see all 960):
		AASDHPPT ABCC12 ABCG1 ABLIM1 ABP1 ACAD8 ACCS ACN9 ACO2 ACTL6A

miRNA Products:		miRTarBase miRNAs that target AHR: hsa-mir-124 (MIRT002653)

		OriGene 3'-UTR Clone: AHR Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AHR
		8/63 QIAGEN miScript miRNA Assays for microRNAs that regulate AHR (see all 63):
		hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-29a hsa-miR-219-5p hsa-miR-502-3p hsa-miR-548l hsa-miR-548m

		SwitchGear 3'UTR luciferase reporter plasmid: AHR 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AHR (see all 7) OriGene shRNA RFP: AHR OriGene siRNA: AHR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AHR

Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for AHR
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHR

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	TAS	19538249
GO:0003700	sequence-specific DNA binding transcription factor activity	IDA	11782478
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	IEA	--
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	IDA	10395741
GO:0005515	protein binding	IPI	9079689

AHR for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for AHR:

Increased cell death HMECs cel

Animal Models:
Mouse knock-outs for AHR: Ahr^tm1Gonz Ahr^tm1Bra
15/18 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Ahr) (see all 18):

cardiovascular system	digestive/alimentary	endocrine/exocrine gland	growth/size	hematopoietic system
homeostasis/metabolism	immune system	integument	liver/biliary system	mortality/aging
muscle	no phenotypic analysis	renal/urinary system	reproductive system	respiratory system

AHR for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

AHR Pathway

AHR Pathway

1.00

Adipogenesis

Adipogenesis

1.00

Integrated Breast Cancer Pathway

Integrated Breast Cancer Pathway

1.00

PKA activation in glucagon signalling

Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling

0.37

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AHR

AHR Pathway

1 GeneGo (Thomson Reuters) Pathway for AHR

Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling

2 BioSystems Pathways for AHR

	Integrated Breast Cancer Pathway
	Adipogenesis

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for AHR

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/49 Interacting proteins for AHR (P35869^{1, 3} ENSP00000242057⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 49)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARNT	P27540¹^,³, ENSP00000351407⁴	EBI-80780,EBI-80809 I2D: score=10 STRING: ENSP00000351407
NCOR2	Q9Y618¹^,³, ENSP00000348551⁴	EBI-80780,EBI-80830 I2D: score=2 STRING: ENSP00000348551
NCOA7	Q8NI08¹^,³, ENSP00000357341⁴	EBI-80780,EBI-80799 I2D: score=1 STRING: ENSP00000357341
NCOA2	Q15596³, ENSP00000399968⁴	I2D: score=4 STRING: ENSP00000399968
CCNT1	O60563³, ENSP00000261900⁴	I2D: score=3 STRING: ENSP00000261900

About this table

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0001541	ovarian follicle development	--	--
GO:0001568	blood vessel development	NAS	19538249
GO:0006355	regulation of transcription, DNA-dependent	IDA	10395741
GO:0006357	regulation of transcription from RNA polymerase II promoter	IDA	15681594

AHR for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

AHR for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for AHR

Compounds for AHR available from Tocris Bioscience About this table

Compound	Action	CAS #
L-Kynurenine	Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand	[2922-83-0]
ITE	Endogenous agonist for the transcription factor aryl hydrocarbon receptor	[448906-42-1]
Pifithrin-alpha hydrobromide	p53 inhibitor. Also aryl hydrocarbon receptor agonist	[63208-82-2]
6,2',4'-Trimethoxyflavone	Aryl hydrocarbon receptor antagonist	--

1 HMDB Compound for AHR About this table

Compound	Synonyms	CAS #	PubMed Ids
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--

6 DrugBank Compounds for AHR About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Leflunomide	Leflunomidum [INN-Latin] (see all 2)	75706-12-6	target	agonist	20957046 17327465
Atorvastatin	--	134523-00-5	target	agonist	17327465
Flutamide	--	13311-84-7	target	agonist	17327465
Ginseng	--	50647-08-0	target	agonist	19022240
Mexiletine	Mexiletina [INN-Spanish] (see all 4)	31828-71-4	target	agonist	17327465
Nimodipine	Nimodipino [INN-Spanish] (see all 2)	66085-59-4	target	agonist	17327465

10/109 Novoseek chemical compound relationships for AHR gene (see all 109) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tcdd	97.6	1250	10777561 (7), 16613807 (6), 19056653 (6), 9415701 (5) (see all 99)
alpha-naphthoflavone	89.6	129	8385898 (4), 8390116 (3), 16569260 (2), 10630576 (2) (see all 55)
indolo(3,2-b)carbazole	86.3	19	7966413 (3), 15917307 (2), 18219281 (2), 18762178 (1) (see all 7)
hydrocarbons	85.3	119	12673023 (3), 8697610 (1), 9415701 (1), 18950284 (1) (see all 94)
3-methylcholanthrene	85.2	127	8163517 (4), 19270430 (4), 1654865 (4), 16257430 (4) (see all 46)
benzo(a)pyrene	84.7	196	18372000 (4), 19559082 (4), 10230769 (4), 17376491 (3) (see all 78)
pcb 126	83.6	12	18155262 (2), 17512696 (2), 14962508 (1), 16396990 (1) (see all 6)
2-azido-3-(125i)iodo-7,8-dibromodibenzo-p-dioxin	82.3	2	15213304 (1), 1846218 (1)
mcdf	81.9	15	15087408 (2), 15026081 (2), 10822009 (1), 7821706 (1) (see all 7)
beta-naphthoflavone	81.2	60	8385898 (5), 20060304 (2), 11595506 (2), 14751679 (1) (see all 30)

Search CenterWatch for drugs/clinical trials and news about AHR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AHR gene:

NM_001621.4

Unigene Cluster for AHR:

Aryl hydrocarbon receptor

Hs.171189 [show with all ESTs]

Unigene Representative Sequence: NM_001621

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000242057(uc011jxz.1) ENST00000463496 ENST00000475440 ENST00000481944

ENST00000492120

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		hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-29a hsa-miR-219-5p hsa-miR-502-3p hsa-miR-548l hsa-miR-548m

		SwitchGear 3'UTR luciferase reporter plasmid: AHR 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AHR

Additional cDNA sequence:

AK130815.1 AK307495.1 BC021696.1 BC069390.1 BC070080.1 D16354.1

9 DOTS entries:

DT.454488 DT.100654226 DT.92428380 DT.97831966 DT.100654222 DT.100654223 DT.100654225 DT.100654220

DT.91664671

24/208 AceView cDNA sequences (see all 208):

CB216067 BC069390 AI306430 AI986448 H77668 BM724349 CA412565 D16354

BQ719892 BC021696 BX283596 BM955721 CB116426 AI361164 N90226 BQ025841

BU149806 CD516264 AU185443 BP337076 BG178882 AI537555 BC070080 CN483485

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AHR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATAGATTTT

About this image

AHR expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Perivenous Hepatocytes

Selective marker (cell-identifying gene)

Liver

Eye

Outer Nuclear Layer

Mature Rod Cells

Photoreceptors, Retina

Lower Urinary Tract

Ureter

Lower Urinary Tract

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

See AHR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AHR

SOURCE GeneReport for Unigene cluster: Hs.171189

UniProtKB/Swiss-Prot: AHR_HUMAN, P35869

Tissue specificity: Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and

skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Arrays including AHR (see all 8):

Nuclear Receptors & Coregulators in human mouse rat

Drug Metabolism in human mouse rat

Estrogen Receptor Signaling in human mouse rat

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

WNT Signaling Targets in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AHR

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for AHR gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
chicken (Gallus gallus)	Aves	AHR¹	aryl hydrocarbon receptor	72.16(n) 67.96(a)	373907 NM_204118.1 NP_989449.1
African clawed frog (Xenopus laevis)	Amphibia	AHR²	aryl hydrocarbon receptor	75.09(n)	AB109555.1
zebrafish (Danio rerio)	Actinopterygii	ahr1²	aryl hydrocarbon receptor 1	73.28(n)	246224 AF258854.1
fruit fly (Drosophila melanogaster)	Insecta	ss³	transcription from Pol II promoter transcription more	45(a)	--
worm (Caenorhabditis elegans)	Secernentea	ahr-1³	aryl hydrocarbon (AH) receptor	34(a)	I(9530635-9539155) --

ENSEMBL Gene Tree for AHR (if available)
TreeFam Gene Tree for AHR (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for AHR gene

AHRR²

AHR for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for AHR
PGOHUM00000243513

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142923157^1,2		--	17336396(+)	`ATCCTA/CAACTT`	1	--	us2k¹		0	--	--	--	--
rs186548381^1,2		--	17336493(+)	`TTTTTA/TAAATC`	1	--	us2k¹		0	--	--	--	--
rs192331557^1,2		--	17336521(+)	`TCATTA/GCATTT`	1	--	us2k¹		0	--	--	--	--
rs35703484^1,2	C,F,	--	17336597(+)	`TTTTTC/AACCCT`	1	--	us2k¹		5		MN	392
rs181972032^1,2		--	17336643(+)	`ACTTAC/GACGTT`	1	--	us2k¹		0	--	--	--	--
rs148099323^1,2		--	17336912(+)	`ATCTAC/TTTCCT`	1	--	us2k¹		0	--	--	--	--
rs73680653^1,2	C,	--	17337165(+)	`TCCTGT/CGAACT`	1	--	us2k¹		2		WA	120
rs185167128^1,2		--	17337316(+)	`TTATGC/TTTTGG`	1	--	us2k¹		0	--	--	--	--
rs112283015^1,2		--	17337343(+)	`CTTTCG/AGTATC`	1	--	us2k¹		1		CSA	2
rs189834039^1,2		--	17337375(+)	`CTCTTC/GCCTCA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for AHR (17338246 - 17385776 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for AHR
5 CNVs: 5236 8551 2685 3668 31337
Human Gene Mutation Database (HGMD): AHR

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AHR

DNA2.0 Custom Variant and Variant Library Synthesis for AHR

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

AHR for disorders           About GeneDecksing

OMIM gene information: 600253    OMIM disorders: --

20/90 diseases for AHR (see all 90):    About MalaCards

hepatitis b porphyria cutanea tarda age related macular degeneration hepatitis

non-small cell lung carcinoma eosinophilic fasciitis non-hodgkin lymphoma clear cell adenocarcinoma

micropenis soft tissue sarcoma seborrheic dermatitis iron overload

ovarian clear cell adenocarcinoma hydronephrosis porphyria macular degeneration

placental choriocarcinoma fasciitis oral squamous cell carcinoma squamous cell carcinoma

10/56 Novoseek disease relationships for AHR gene (see all 56) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ahh inducibility	60.8	1	7550366 (1)
breast cancer	58.8	101	11408954 (4), 11179685 (3), 11114727 (3), 10922479 (2) (see all 64)
chemical carcinogenesis	45.4	2	15794642 (1), 12369945 (1)
mammary tumor	43.7	15	16972784 (2), 7966413 (1), 11179685 (1), 14973392 (1) (see all 11)
cancer	33.7	50	19690180 (4), 15028720 (2), 19015043 (2), 8395783 (2) (see all 29)
adenocarcinoma lung	31.8	19	19358281 (6), 17200336 (5), 14644512 (1), 17127240 (1)
porphyria	23	9	18163543 (2), 11854449 (1), 9918132 (1), 8638948 (1)
colon adenocarcinoma	22.1	3	16115717 (1), 8163517 (1), 1654865 (1)
micropenis	22	1	15758562 (1)
endometriosis	21.5	12	16084889 (4), 10724351 (4), 12200463 (1), 11393538 (1) (see all 5)

Genetic Association Database (GAD): AHR
Human Genome Epidemiology (HuGE) Navigator: AHR (92 documents)

Export disorders for AHR gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for AHR gene, integrated from 9 sources (see all 1050):
(articles sorted by number of sources associating them with AHR)

Utopia: connect your pdf to the dynamic
world of online information

Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer. (PubMed id 11698344)^{1, 2, 4, 9} Cauchi S.... Massaad-Massade L. (2001)
Analysis of the AhR, ARNT, and AhRR gene polymorphisms: genetic contribution to endometriosis susceptibility and severity. (PubMed id 16084889)^{1, 4, 9} Tsuchiya M.... Ikenoue T. (2005)
Genetic polymorphisms and transcriptional pattern analysis of CYP1A1, AhR, GSTM1, GSTP1 and GSTT1 genes in breast cancer. (PubMed id 11408954)^{1, 4, 9} Dialyna I.A....Spandidos D.A. (2001)
Polymorphism of alpha-estrogen receptor and aryl hydrocarbon receptor genes in dementia patients in Shanghai suburb. (PubMed id 12852830)^{1, 4, 9} Lin G.F....Shen J.H. (2003)
Human arylhydrocarbon receptor repressor (AHRR) gene: genomic structure and analysis of polymorphism in endometriosis. (PubMed id 11393538)^{1, 4, 9} Watanabe T....Inazawa J. (2001)
Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. (PubMed id 10739168)^{1, 2, 9} Smart J. and Daly A.K. (2000)
Interindividual difference in expression of human Ah receptor and related P450 genes. (PubMed id 7515333)^{1, 2, 9} Hayashi S.... Kawajiri K. (1994)
Association of micropenis with Pro185Ala polymorphism of the gene for aryl hydrocarbon receptor repressor involved in dioxin signaling. (PubMed id 15758562)^{1, 4, 9} Soneda S....Ogata T. (2005)
Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study. (PubMed id 16103451)^{1, 4, 9} Le Marchand L....Wilkens L.R. (2005)
Role of the aryl hydrocarbon receptor in cell cycle regulation. (PubMed id 12213388)^{1, 2, 9} Puga A.... Elferink C. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 196	HGNC: 348	AceView: AHR	Ensembl:ENSG00000106546	euGenes: HUgn196
ECgene: AHR	H-InvDB: AHR

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for AHR	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for AHR	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for AHR gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for AHR gene:
Search GeneIP for patents involving AHR

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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