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AHR Gene

protein-coding   GIFtS: 68
GCID: GC07P017304

Aryl Hydrocarbon Receptor

  See AHR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aryl Hydrocarbon Receptor1 2     AH-receptor2
Ah Receptor2 3     Aromatic Hydrocarbon Receptor2
Class E Basic Helix-Loop-Helix Protein 762 3     AhR3
bHLHe762 3     BHLHE763

External Ids:    HGNC: 3481   Entrez Gene: 1962   Ensembl: ENSG000001065467   OMIM: 6002535   UniProtKB: P358693   

Export aliases for AHR gene to outside databases

Previous GC identifers: GC07P016982 GC07P017082 GC07P017111 GC07P017224


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AHR Gene:
This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to
planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as
cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. (provided by RefSeq, Jul 2008)

GeneCards Summary for AHR Gene:
AHR (aryl hydrocarbon receptor) is a protein-coding gene. Diseases associated with AHR include eosinophilic fasciitis, and toxic oil syndrome. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ARNT2.

UniProtKB/Swiss-Prot: AHR_HUMAN, P35869
Function: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates.
Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the
CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle
regulation. Likely to play an important role in the development and maturation of many tissues

summary for AHR Gene:
Aryl hydrocarbon receptors (AHRs) are cytosolic transcription factors that exist bound to co-chaperones in
the resting state (Hsp90, prostaglandin E synthase 3 and hepatitis B virus X-associated protein 2). Ligand
binding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize with
AHR nuclear translocator (ARNT) and alter transcription of target genes. AHR is an evolutionary conserved
receptor that has roles in cell proliferation and differentiation and induction of xenobiotic-metabolizing
enzymes (for example CYP1A1). The human gene encoding the aryl hydrocarbon receptor has been localized to
chromosome 7p15.

Gene Wiki entry for AHR (Aryl hydrocarbon receptor) Gene

PharmGKB "VIP" summary for AHR


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the AHR gene promoter:
         GR   Max1   Sp1   HNF-3beta   PPAR-gamma1   PPAR-gamma2   GR-alpha   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): AHR promoter sequence
   Search Chromatin IP Primers for AHR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AHR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15   Ensembl cytogenetic band:  7p21.1   HGNC cytogenetic band: 7p15

AHR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AHR gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P017304:  view genomic region     (about GC identifiers)

Start:
17,338,246 bp from pter      End:
17,385,776 bp from pter
Size:
47,531 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 17,391,672-17,439,185     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AHR_HUMAN, P35869 (See protein sequence)
Recommended Name: Aryl hydrocarbon receptor precursor  
Size: 848 amino acids; 96147 Da
Subunit: Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. In
the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with
the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP
Secondary accessions: A4D130 Q13728 Q13803 Q13804

Explore the universe of human proteins at neXtProt for AHR: NX_P35869

Explore proteomics data for AHR at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AHR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001612.1  
    ENSEMBL proteins: 
     ENSP00000242057   ENSP00000436466  

    AHR Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for AHR
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    GenScript Custom Purified and Recombinant Proteins Services for AHR
    Novus Biologicals AHR Proteins
    Novus Biologicals AHR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for AHR 

     
    antibodies-online proteins for AHR (10 products) 

     
    antibodies-online peptides for AHR

    AHR Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of AHR
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    OriGene Custom Antibody Services for AHR
    Novus Biologicals AHR Antibodies
    Abcam antibodies for AHR
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for AHR
    antibodies-online antibodies for AHR (130 products) 

    AHR Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AHR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AHR
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for AHR 
    antibodies-online kits for AHR (35 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    5 InterPro protein domains:
     IPR013655 PAS_fold_3
     IPR001610 PAC
     IPR013767 PAS_fold
     IPR000014 PAS
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry P35869

    ProtoNet protein and cluster: P35869

    3 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB001610 PAC motif
    IPB013655 PAS fold-3


    UniProtKB/Swiss-Prot: AHR_HUMAN, P35869
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
    Similarity: Contains 2 PAS (PER-ARNT-SIM) domains


    Find genes that share domains with AHR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AHR_HUMAN, P35869
    Function: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates.
    Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the
    CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle
    regulation. Likely to play an important role in the development and maturation of many tissues
    Induction: Induced or repressed by TGFB1 and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic
    acid, and 12-O-tetradecanoyl phorbol-13 acetate (TPA)

         Genatlas biochemistry entry for AHR:
    aryl hydrocarbon receptor,unliganded,retained in cytoplasm in resting state in association with HSP90,and with AIP
    (AH receptor associated protein 9),released after exposure to xenobiotics,dimerizing with ARNT and translocated
    to the nucleus interacting with pRB1 to induce G1 arrest

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS19538249
    GO:0003700sequence-specific DNA binding transcription factor activity IDA11782478
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA--
    GO:0004871signal transducer activity IEA--
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IDA10395741
         
    Find genes that share ontologies with AHR           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for AHR:
     Increased cell death HMECs cel 

         Selected MGI mutant phenotypes (inferred from 12 alleles(MGI details for Ahr) (see all 21):
     behavior/neurological  cardiovascular system  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system  integument 
     liver/biliary system  mortality/aging  muscle  nervous system  no phenotypic analysis 

    Find genes that share phenotypes with AHR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for AHR: Ahrtm1Gonz Ahrtm1Bra

       genOway: Develop your customized and physiologically relevant rodent model for AHR

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for AHR (see all 927):
    AASDHPPT,  ABCC12,  ABCG1,  ABLIM1,  ACAD8,  ACCS,  ACN9,  ACO2,  ACTL6A,  ACTN1

    miRNA
    Products:
        
    miRTarBase miRNAs that target AHR:
    hsa-mir-130b-3p (MIRT020178), hsa-mir-26a-5p (MIRT050123), hsa-mir-625-5p (MIRT039593), hsa-mir-124-3p (MIRT002653), hsa-mir-98-5p (MIRT027562)

    Block miRNA regulation of human, mouse, rat AHR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AHR (see all 63):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-29a hsa-miR-219-5p hsa-miR-502-3p hsa-miR-548l hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidAHR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AHR
    Predesigned siRNA for gene silencing in human, mouse, rat AHR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AHR

    Clone
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    OriGene clones in human, mouse for AHR (see all 6)
    OriGene ORF clones in mouse, rat for AHR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AHR (NM_001621)
    Sino Biological Human cDNA Clone for AHR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AHR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHR

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for AHR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AHR_HUMAN, P35869: Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction
    with a HSP90, it translocates to the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    endoplasmic reticulum4
    peroxisome2
    cytoskeleton1
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex TAS19538249
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0034752cytosolic aryl hydrocarbon receptor complex TAS19538249

    Find genes that share ontologies with AHR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AHR About    
    See pathways by source

    SuperPathContained pathways About
    1Ca-dependent events
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    2Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway
    3AhR pathway (WikiPathways)
    AhR pathway
    4AHR Pathway (Qiagen)
    AHR Pathway
    5Adipogenesis
    Adipogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for AHR
        AHR Pathway

    1 GeneGo (Thomson Reuters) Pathway for AHR
        Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling

    3 BioSystems Pathways for AHR
        Adipogenesis
    Integrated Breast Cancer Pathway
    AhR pathway



        Pathway & Disease-focused RT2 Profiler PCR Arrays including AHR (see all 8): 
              Nuclear Receptors & Coregulators in human mouse rat
              Drug Metabolism in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              WNT Signaling Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AHR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AHR (P358691, 3 ENSP000002420574) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCOR2Q9Y6181, 3, ENSP000003485514EBI-80780,EBI-80830 I2D: score=2 STRING: ENSP00000348551
    ARNTP275401, 3, ENSP000003514074EBI-80780,EBI-80809 I2D: score=10 STRING: ENSP00000351407
    NCOA7Q8NI081, 3, ENSP000003573414EBI-80780,EBI-80799 I2D: score=1 STRING: ENSP00000357341
    NCOA2Q155963, ENSP000003999684I2D: score=4 STRING: ENSP00000399968
    CCNT1O605633, ENSP000002619004I2D: score=3 STRING: ENSP00000261900
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001568blood vessel development NAS19538249
    GO:0006355regulation of transcription, DNA-templated IDA10395741
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA15681594
    GO:0006366transcription from RNA polymerase II promoter IDA10395741

    Find genes that share ontologies with AHR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for AHR
      Browse compounds at ApexBio 

    Compounds for AHR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CH 223191Potent aryl hydrocarbon receptor (AhR) antagonist[301326-22-7]
    DiMNFSelective aryl hydrocarbon receptor modulator (SAhRM)[14756-24-2]

    1 HMDB Compound for AHR    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    6 DrugBank Compounds for AHR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Atorvastatin-- 134523-00-5targetagonist23703578 17327465
    LeflunomideLeflunomidum [INN-Latin] (see all 2)75706-12-6targetagonist20957046 17327465
    Flutamide-- 13311-84-7targetagonist17327465
    Ginseng-- 50647-08-0targetagonist19022240
    MexiletineMexiletina [INN-Spanish] (see all 4)31828-71-4targetagonist17327465
    NimodipineNimodipino [INN-Spanish] (see all 2)66085-59-4targetagonist17327465

    Selected Novoseek inferred chemical compound relationships for AHR gene (see all 109)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tcdd 97.6 1250 10777561 (7), 16613807 (6), 19056653 (6), 9415701 (5) (see all 99)
    alpha-naphthoflavone 89.6 129 8385898 (4), 8390116 (3), 16569260 (2), 10630576 (2) (see all 55)
    indolo(3,2-b)carbazole 86.3 19 7966413 (3), 15917307 (2), 18219281 (2), 18762178 (1) (see all 7)
    hydrocarbons 85.3 119 12673023 (3), 8697610 (1), 9415701 (1), 18950284 (1) (see all 94)
    3-methylcholanthrene 85.2 127 8163517 (4), 19270430 (4), 1654865 (4), 16257430 (4) (see all 46)
    benzo(a)pyrene 84.7 196 18372000 (4), 19559082 (4), 10230769 (4), 17376491 (3) (see all 78)
    pcb 126 83.6 12 18155262 (2), 17512696 (2), 14962508 (1), 16396990 (1) (see all 6)
    2-azido-3-(125i)iodo-7,8-dibromodibenzo-p-dioxin 82.3 2 15213304 (1), 1846218 (1)
    mcdf 81.9 15 15087408 (2), 15026081 (2), 10822009 (1), 7821706 (1) (see all 7)
    beta-naphthoflavone 81.2 60 8385898 (5), 20060304 (2), 11595506 (2), 14751679 (1) (see all 30)



    Find genes that share compounds with AHR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AHR gene: 
    NM_001621.4  

    Unigene Cluster for AHR:

    Aryl hydrocarbon receptor
    Hs.171189  [show with all ESTs]
    Unigene Representative Sequence: NM_001621
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000242057(uc011jxz.1) ENST00000463496 ENST00000475440 ENST00000481944
    ENST00000492120
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate AHR (see all 63):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-29a hsa-miR-219-5p hsa-miR-502-3p hsa-miR-548l hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidAHR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AHR
    Clone
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    OriGene ORF clones in mouse, rat for AHR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AHR (NM_001621)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AHR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHR
    Primer
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    OriGene qPCR primer pairs and template standards for AHR
    OriGene qSTAR qPCR primer pairs in human, mouse for AHR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AHR
      QuantiTect SYBR Green Assays in human, mouse, rat AHR
      QuantiFast Probe-based Assays in human, mouse, rat AHR

    Additional mRNA sequence: 

    AK130815.1 AK307495.1 BC021696.1 BC069390.1 BC070080.1 D16354.1 

    9 DOTS entries:

    DT.454488  DT.100654226  DT.92428380  DT.97831966  DT.100654222  DT.100654223  DT.100654220  DT.100654225 
    DT.91664671 

    Selected AceView cDNA sequences (see all 208):

    AI801360 N90226 AU185443 AI306430 CB116426 AI986448 BM724349 BQ025841 
    CA412565 BC069390 CD516264 D16354 BC070080 BG178882 BC021696 BP337076 
    BQ719892 BQ024331 CN483485 AI860369 AI537555 H77668 AI082089 BX283596 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    AHR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATAGATTTT
    AHR Expression
    About this image


    AHR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 7 entries
             Odontoblasts Dentin
             Dentin
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Cerebral Cortex
     
     Liver (Hepatobiliary System)
             Perivenous Hepatocytes Liver Lobule
     
     Epithelial Cells
             Early Ameloblasts Dental Enamel
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Rod Cells Outer Nuclear Layer
    AHR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AHR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.171189

    UniProtKB/Swiss-Prot: AHR_HUMAN, P35869
    Tissue specificity: Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas
    and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AHR (see all 8): 
              Nuclear Receptors & Coregulators in human mouse rat
              Drug Metabolism in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              WNT Signaling Targets in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AHR gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ahr1 , 5 aryl-hydrocarbon receptor1, 5 79.17(n)1
    74.62(a)1
      12 (15.78 cM)5
    116221  NM_013464.41  NP_038492.11 
     354979745 
    chicken
    (Gallus gallus)
    Aves AHR1 aryl hydrocarbon receptor 71.87(n)
    67.39(a)
      373907  NM_204118.1  NP_989449.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia AHR2 aryl hydrocarbon receptor 75.09(n)    AB109555.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ahr12 aryl hydrocarbon receptor 1 73.28(n)   246224  AF258854.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ss3 transcription from Pol II promoter
    transcription more
    45(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea ahr-13 aryl hydrocarbon (AH) receptor 34(a)   I(9530635-9539155)   --


    ENSEMBL Gene Tree for AHR (if available)
    TreeFam Gene Tree for AHR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AHR gene
    ARNT22  CLOCK2  NPAS22  ARNT2  EPAS12  NPAS32  HIF1A2  SIM22  
    SIM12  HIF3A2  ARNTL2  NPAS12  ARNTL22  AHRR2  

    Find genes that share paralogs with AHR           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for AHR
    PGOHUM00000243513


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AHR (see all 927)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429231571,2
    --17336396(+) ATCCTA/CAACTT 1 -- us2k10--------
    rs1865483811,2
    --17336493(+) TTTTTA/TAAATC 1 -- us2k10--------
    rs1923315571,2
    --17336521(+) TCATTA/GCATTT 1 -- us2k10--------
    rs357034841,2
    C,F--17336597(+) TTTTTC/AACCCT 1 -- us2k15Minor allele frequency- A:0.01MN 392
    rs1819720321,2
    --17336643(+) ACTTAC/GACGTT 1 -- us2k10--------
    rs1480993231,2
    --17336912(+) ATCTAC/TTTCCT 1 -- us2k10--------
    rs736806531,2
    C,F--17337165(+) TCCTGT/CGAACT 1 -- us2k12Minor allele frequency- C:0.08WA 120
    rs1851671281,2
    --17337316(+) TTATGC/TTTTGG 1 -- us2k10--------
    rs1122830151,2
    F--17337343(+) CTTTCG/AGTATC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1898340391,2
    --17337375(+) CTCTTC/GCCTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AHR (17338246 - 17385776 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AHR (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422294CNV Duplication17116639
    nsv887793CNV Loss21882294
    nsv887792CNV Loss21882294
    nsv464399CNV Gain19166990
    dgv7217n71CNV Gain21882294
    dgv7220n71CNV Gain21882294
    esv34717CNV Gain17911159
    nsv464398CNV Gain19166990
    nsv8064CNV Gain18304495
    essv2917CNV CNV17122850

    Human Gene Mutation Database (HGMD): AHR
    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for AHR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600253    OMIM disorders: --

    10 diseases for AHR:    
    About MalaCards
    eosinophilic fasciitis    toxic oil syndrome    hepatitis b    hydronephrosis
    choriocarcinoma    fasciitis    clear cell adenocarcinoma    endometriosis
    hepatitis    breast cancer

    4 diseases from the University of Copenhagen DISEASES database for AHR:
    Hepatocellular carcinoma     Hydronephrosis     Breast cancer     Cleft palate

    Find genes that share disorders with AHR           About GenesLikeMe

    Selected Novoseek inferred disease relationships for AHR gene (see all 56)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ahh inducibility 60.8 1 7550366 (1)
    breast cancer 58.8 101 11408954 (4), 11179685 (3), 11114727 (3), 10922479 (2) (see all 64)
    chemical carcinogenesis 45.4 2 15794642 (1), 12369945 (1)
    mammary tumor 43.7 15 16972784 (2), 7966413 (1), 11179685 (1), 14973392 (1) (see all 11)
    cancer 33.7 50 19690180 (4), 15028720 (2), 19015043 (2), 8395783 (2) (see all 29)
    adenocarcinoma lung 31.8 19 19358281 (6), 17200336 (5), 14644512 (1), 17127240 (1)
    porphyria 23 9 18163543 (2), 11854449 (1), 9918132 (1), 8638948 (1)
    colon adenocarcinoma 22.1 3 16115717 (1), 8163517 (1), 1654865 (1)
    micropenis 22 1 15758562 (1)
    endometriosis 21.5 12 16084889 (4), 10724351 (4), 12200463 (1), 11393538 (1) (see all 5)

    Genetic Association Database (GAD): AHR
    Human Genome Epidemiology (HuGE) Navigator: AHR (92 documents)

    Export disorders for AHR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AHR gene, integrated from 10 sources (see all 1097):
    (articles sorted by number of sources associating them with AHR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer. (PubMed id 11698344)1, 2, 4, 9 Cauchi S.... Massaad-Massade L. (Carcinogenesis 2001)
    2. Analysis of the AhR, ARNT, and AhRR gene polymorphisms: genetic contribution to endometriosis susceptibility and severity. (PubMed id 16084889)1, 4, 9 Tsuchiya M.... Ikenoue T. (Fertil. Steril. 2005)
    3. Genetic polymorphisms and transcriptional pattern analysis of CYP1A1, AhR, GSTM1, GSTP1 and GSTT1 genes in breast cancer. (PubMed id 11408954)1, 4, 9 Dialyna I.A....Spandidos D.A. (Int. J. Mol. Med. 2001)
    4. The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility. (PubMed id 17559847)1, 4, 9 Merisalu A....Salumets A. (Fertil. Steril. 2007)
    5. Interaction between organochlorines and the AHR gene, and risk of non-Hodgkin lymphoma. (PubMed id 19821039)1, 4, 9 Ng C.H....Spinelli J.J. (amp 2010)
    6. Association of polymorphisms in AhR, CYP1A1, GSTM1, and GSTT1 genes with levels of DNA damage in peripheral blood lymphocytes among coke-oven workers. (PubMed id 16985033)1, 4, 9 Chen Y....Wu T. (amp 2006)
    7. Polymorphism of alpha-estrogen receptor and aryl hydrocarbon receptor genes in dementia patients in Shanghai suburb. (PubMed id 12852830)1, 4, 9 Lin G.F....Shen J.H. (Acta Pharmacol. Sin. 2003)
    8. Human arylhydrocarbon receptor repressor (AHRR) gene: genomic structure and analysis of polymorphism in endometriosis. (PubMed id 11393538)1, 4, 9 Watanabe T....Inazawa J. (J. Hum. Genet. 2001)
    9. Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. (PubMed id 10739168)1, 2, 9 Smart J. and Daly A.K. (Pharmacogenetics 2000)
    10. Interindividual difference in expression of human Ah receptor and related P450 genes. (PubMed id 7515333)1, 2, 9 Hayashi S.... Kawajiri K. (Carcinogenesis 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 196 HGNC: 348 AceView: AHR Ensembl:ENSG00000106546 euGenes: HUgn196
    ECgene: AHR H-InvDB: AHR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AHR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AHR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AHR gene:
    Search GeneIP for patents involving AHR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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