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Aliases for AHR Gene

Aliases for AHR Gene

  • Aryl Hydrocarbon Receptor 2 3
  • Class E Basic Helix-Loop-Helix Protein 76 3 4
  • Ah Receptor 3 4
  • BHLHe76 3 4
  • Aromatic Hydrocarbon Receptor 3
  • AH-Receptor 3
  • AhR 4

External Ids for AHR Gene

Summaries for AHR Gene

Entrez Gene Summary for AHR Gene

  • This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. [provided by RefSeq, Jul 2008]

GeneCards Summary for AHR Gene

AHR (Aryl Hydrocarbon Receptor) is a Protein Coding gene. Diseases associated with AHR include eosinophilic fasciitis and toxic oil syndrome. Among its related pathways are AhR pathway (WikiPathways) and AHR Pathway (Qiagen). GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is AHRR.

UniProtKB/Swiss-Prot for AHR Gene

  • Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.

Tocris Summary for AHR Gene

  • Aryl hydrocarbon receptors (AHRs) are cytosolic transcription factors that exist bound to co-chaperones in the resting state (Hsp90, prostaglandin E synthase 3 and hepatitis B virus X-associated protein 2). Ligand binding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize with AHR nuclear translocator (ARNT) and alter transcription of target genes. AHR is an evolutionary conserved receptor that has roles in cell proliferation and differentiation and induction of xenobiotic-metabolizing enzymes (for example CYP1A1). The human gene encoding the aryl hydrocarbon receptor has been localized to chromosome 7p15.

Gene Wiki entry for AHR Gene

PharmGKB "VIP" Summary for AHR Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for AHR Gene

Genomics for AHR Gene

Genomic Location for AHR Gene

Start:
17,298,622 bp from pter
End:
17,346,152 bp from pter
Size:
47,531 bases
Orientation:
Plus strand

Genomic View for AHR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AHR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AHR Gene

Regulatory Elements for AHR Gene

Proteins for AHR Gene

  • Protein details for AHR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35869-AHR_HUMAN
    Recommended name:
    Aryl hydrocarbon receptor
    Protein Accession:
    P35869
    Secondary Accessions:
    • A4D130
    • Q13728
    • Q13803
    • Q13804

    Protein attributes for AHR Gene

    Size:
    848 amino acids
    Molecular mass:
    96147 Da
    Quaternary structure:
    • Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP. Interacts with ARNTL/BMAL1.

neXtProt entry for AHR Gene

Proteomics data for AHR Gene at MOPED

Post-translational modifications for AHR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AHR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AHR Gene

Domains for AHR Gene

Gene Families for AHR Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Suggested Antigen Peptide Sequences for AHR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35869

UniProtKB/Swiss-Prot:

AHR_HUMAN
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • P35869
  • Contains 1 PAC (PAS-associated C-terminal) domain.:
    • P35869
  • Contains 2 PAS (PER-ARNT-SIM) domains.:
    • P35869
genes like me logo Genes that share domains with AHR: view

Function for AHR Gene

Molecular function for AHR Gene

GENATLAS Biochemistry: aryl hydrocarbon receptor,unliganded,retained in cytoplasm in resting state in association with HSP90,and with AIP (AH receptor associated protein 9),released after exposure to xenobiotics,dimerizing with ARNT and translocated to the nucleus interacting with pRB1 to induce G1 arrest
UniProtKB/Swiss-Prot Function: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.
UniProtKB/Swiss-Prot Induction: Induced or repressed by TGFB1 and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic acid, and 12-O-tetradecanoyl phorbol-13 acetate (TPA).

Gene Ontology (GO) - Molecular Function for AHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 19538249
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 11782478
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA --
GO:0004871 signal transducer activity IEA --
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IDA 10395741
genes like me logo Genes that share ontologies with AHR: view
genes like me logo Genes that share phenotypes with AHR: view

Animal Models for AHR Gene

MGI Knock Outs for AHR:

Transcription Factor Targeting for AHR Gene

Selected GeneGlobe predicted Target genes for AHR

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for AHR Gene

Localization for AHR Gene

Subcellular locations from UniProtKB/Swiss-Prot for AHR Gene

Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AHR Gene COMPARTMENTS Subcellular localization image for AHR gene
Compartment Confidence
nucleus 5
cytosol 4
endoplasmic reticulum 4
peroxisome 2
cytoskeleton 1
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10395741
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex TAS 19538249
GO:0005737 cytoplasm IDA --
GO:0034752 cytosolic aryl hydrocarbon receptor complex TAS 19538249
genes like me logo Genes that share ontologies with AHR: view

Pathways for AHR Gene

genes like me logo Genes that share pathways with AHR: view

Pathways by source for AHR Gene

1 GeneGo (Thomson Reuters) pathway for AHR Gene
1 Qiagen pathway for AHR Gene
3 BioSystems pathways for AHR Gene

Gene Ontology (GO) - Biological Process for AHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001568 blood vessel development NAS 19538249
GO:0006355 regulation of transcription, DNA-templated IDA 10395741
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 15681594
GO:0006366 transcription from RNA polymerase II promoter IDA 10395741
genes like me logo Genes that share ontologies with AHR: view

Compounds for AHR Gene

(2) Tocris Compounds for AHR Gene

Compound Action Cas Number
CH 223191 Potent aryl hydrocarbon receptor (AhR) antagonist [301326-22-7]
DiMNF Selective aryl hydrocarbon receptor modulator (SAhRM) [14756-24-2]

(1) HMDB Compounds for AHR Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4

(6) Drugbank Compounds for AHR Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Atorvastatin
134523-00-5 target agonist
Flutamide
13311-84-7 target agonist
Ginseng
50647-08-0 target agonist
Leflunomide
  • Leflunomidum [INN-Latin]
75706-12-6 target agonist
Mexiletine
  • Mexiletina [INN-Spanish]
31828-71-4 target agonist

(109) Novoseek inferred chemical compound relationships for AHR Gene

Compound -log(P) Hits PubMed IDs
tcdd 97.6 294
alpha-naphthoflavone 89.6 63
indolo(3,2-b)carbazole 86.3 11
hydrocarbons 85.3 96
3-methylcholanthrene 85.2 73
genes like me logo Genes that share compounds with AHR: view

Transcripts for AHR Gene

Unigene Clusters for AHR Gene

Aryl hydrocarbon receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AHR Gene

No ASD Table

Relevant External Links for AHR Gene

GeneLoc Exon Structure for
AHR
ECgene alternative splicing isoforms for
AHR

Expression for AHR Gene

mRNA expression in normal human tissues for AHR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AHR Gene

This gene is overexpressed in Nerve - Tibial (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AHR Gene

SOURCE GeneReport for Unigene cluster for AHR Gene Hs.171189

mRNA Expression by UniProt/SwissProt for AHR Gene

P35869-AHR_HUMAN
Tissue specificity: Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle.
genes like me logo Genes that share expressions with AHR: view

Orthologs for AHR Gene

This gene was present in the common ancestor of animals.

Orthologs for AHR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AHR 35
  • 98.9 (n)
  • 98.58 (a)
AHR 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AHR 35
  • 84.39 (n)
  • 80.93 (a)
AHR 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AHR 35
  • 87.78 (n)
  • 84.93 (a)
AHR 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ahr 35
  • 79.17 (n)
  • 74.62 (a)
Ahr 16
Ahr 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AHR 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AHR 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ahr 35
  • 77.84 (n)
  • 73.15 (a)
chicken
(Gallus gallus)
Aves AHR 35
  • 71.87 (n)
  • 67.39 (a)
AHR 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia AHR 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ahr 35
  • 65.53 (n)
  • 60.61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11494 35
zebrafish
(Danio rerio)
Actinopterygii ahr1 35
ahr1a 36
  • 41 (a)
OneToOne
ahr1b 35
  • 60.47 (n)
  • 60.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta ss 36
  • 22 (a)
OneToMany
ss 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea ahr-1 36
  • 30 (a)
OneToMany
ahr-1 37
  • 34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12569 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for AHR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AHR Gene

ENSEMBL:
Gene Tree for AHR (if available)
TreeFam:
Gene Tree for AHR (if available)

Paralogs for AHR Gene

Pseudogenes.org Pseudogenes for AHR Gene

genes like me logo Genes that share paralogs with AHR: view

Variants for AHR Gene

Sequence variations from dbSNP and Humsavar for AHR Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1135845 -- 17,345,258(+) tgcag(A/G)gccaa utr-variant-3-prime
rs1476080 -- 17,318,249(-) ATATC(A/C)CATGC intron-variant
rs1557737 -- 17,343,483(-) GTTCT(C/G/T)TAACT utr-variant-3-prime
rs1803079 -- 17,345,646(+) TTAAT(C/T)ATGAA utr-variant-3-prime
rs1803080 -- 17,345,574(+) TCTTA(C/T)ATAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for AHR Gene

Variant ID Type Subtype PubMed ID
dgv7217n71 CNV Gain 21882294
nsv464398 CNV Gain 19166990
dgv2066e1 CNV Complex 17122850
nsv464399 CNV Gain 19166990
dgv7220n71 CNV Gain 21882294
nsv8064 CNV Gain 18304495
essv2917 CNV CNV 17122850
esv34717 CNV Gain 17911159
esv2422294 CNV Duplication 17116639
nsv887792 CNV Loss 21882294
nsv887793 CNV Loss 21882294

Relevant External Links for AHR Gene

HapMap Linkage Disequilibrium report
AHR
Human Gene Mutation Database (HGMD)
AHR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AHR Gene

Disorders for AHR Gene

(4) University of Copenhagen DISEASES for AHR Gene

(56) Novoseek inferred disease relationships for AHR Gene

Disease -log(P) Hits PubMed IDs
ahh inducibility 60.8 1
breast cancer 58.8 81
chemical carcinogenesis 45.4 2
mammary tumor 43.7 12
cancer 33.7 37

Relevant External Links for AHR

Genetic Association Database (GAD)
AHR
Human Genome Epidemiology (HuGE) Navigator
AHR
genes like me logo Genes that share disorders with AHR: view

No data available for UniProtKB/Swiss-Prot for AHR Gene

Publications for AHR Gene

  1. Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer. (PMID: 11698344) Cauchi S. … Massaad-Massade L. (Carcinogenesis 2001) 3 4 23 48
  2. Role of the aryl hydrocarbon receptor in cell cycle regulation. (PMID: 12213388) Puga A. … Elferink C. (Chem. Biol. Interact. 2002) 3 4 23
  3. Ethnic variability in the allelic distribution of human aryl hydrocarbon receptor codon 554 and assessment of variant receptor function in vitro. (PMID: 11207035) Wong J.M. … Okey A.B. (Pharmacogenetics 2001) 3 23 48
  4. Cell-specific regulation of human aryl hydrocarbon receptor expression by transforming growth factor-beta(1). (PMID: 11259615) Wolff S. … Abel J. (Mol. Pharmacol. 2001) 3 4 23
  5. Human arylhydrocarbon receptor repressor (AHRR) gene: genomic structure and analysis of polymorphism in endometriosis. (PMID: 11393538) Watanabe T. … Inazawa J. (J. Hum. Genet. 2001) 3 23 48

Products for AHR Gene

Sources for AHR Gene

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