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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AHR Gene

protein-coding   GIFtS: 69
GCID: GC07P017304

Aryl Hydrocarbon Receptor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Aryl Hydrocarbon Receptor1 2     AH-receptor2
Ah Receptor2 3     Aromatic Hydrocarbon Receptor2
Class E Basic Helix-Loop-Helix Protein 762 3     AhR3
bHLHe762 3     BHLHE763

External Ids:    HGNC: 3481   Entrez Gene: 1962   Ensembl: ENSG000001065467   OMIM: 6002535   UniProtKB: P358693   

Export aliases for AHR gene to outside databases

Previous GC identifers: GC07P016982 GC07P017082 GC07P017111 GC07P017224


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AHR Gene:
This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to
planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as
cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. (provided by RefSeq, Jul 2008)

GeneCards Summary for AHR Gene: 
AHR (aryl hydrocarbon receptor) is a protein-coding gene. Diseases associated with AHR include toxic oil syndrome, and hepatitis b, and among its related super-pathways are PKA activation. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is AHRR.

UniProtKB/Swiss-Prot: AHR_HUMAN, P35869
Function: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates.
Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the
CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle
regulation. Likely to play an important role in the development and maturation of many tissues

summary for AHR Gene:
Aryl hydrocarbon receptors (AHRs) are cytosolic transcription factors that exist bound to co-chaperones in
the resting state (Hsp90, prostaglandin E synthase 3 and hepatitis B virus X-associated protein 2). Ligand
binding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize with
AHR nuclear translocator (ARNT) and alter transcription of target genes. AHR is an evolutionary conserved
receptor that has roles in cell proliferation and differentiation and induction of xenobiotic-metabolizing
enzymes (for example CYP1A1). The human gene encoding the aryl hydrocarbon receptor has been localized to
chromosome 7p15.

Gene Wiki entry for AHR (Aryl hydrocarbon receptor) Gene

PharmGKB "VIP" summary for AHR


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AHR gene promoter:
         GR   Max1   Sp1   HNF-3beta   PPAR-gamma1   PPAR-gamma2   GR-alpha   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): AHR promoter sequence
   Search SABiosciences Chromatin IP Primers for AHR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AHR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15   Ensembl cytogenetic band:  7p21.1   HGNC cytogenetic band: 7p15

AHR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AHR gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P017304:  view genomic region     (about GC identifiers)

Start:
17,338,246 bp from pter      End:
17,385,776 bp from pter
Size:
47,531 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 17,391,672-17,439,185     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AHR_HUMAN, P35869 (See protein sequence)
Recommended Name: Aryl hydrocarbon receptor precursor  
Size: 848 amino acids; 96147 Da
Subunit: Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. In
the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with
the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP
Subcellular location: Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction
with a HSP90, it translocates to the nucleus
Secondary accessions: A4D130 Q13728 Q13803 Q13804

Explore the universe of human proteins at neXtProt for AHR: NX_P35869

Explore proteomics data for AHR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P35869

  • AHR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AHR Protein Expression
    REFSEQ proteins: NP_001612.1  
    ENSEMBL proteins: 
     ENSP00000242057   ENSP00000436466  

    Human Recombinant Protein Products for AHR: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for AHR
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for AHR
    GenScript Custom Purified and Recombinant Proteins Services for AHR
    Novus Biologicals AHR Proteins
    Novus Biologicals AHR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex TAS19538249
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0034752cytosolic aryl hydrocarbon receptor complex TAS19538249

    AHR for ontologies           About GeneDecksing



    AHR Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of AHR
    R&D Systems Antibodies for AHR
    OriGene Antibodies for AHR
    OriGene Custom Antibody Services for AHR
    GenScript Custom Superior Antibodies Services for AHR
    Novus Biologicals AHR Antibodies
    Abcam antibodies for AHR
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for AHR
    LSBio Antibodies in human, mouse, rat for AHR 

    Assay Products for AHR: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AHR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AHR
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bHLH: Basic helix-loop-helix proteins

    5 InterPro protein domains:
     IPR001610 PAC
     IPR013767 PAS_fold
     IPR000014 PAS
     IPR011598 bHLH_dom
     IPR013655 PAS_fold_3

    Graphical View of Domain Structure for InterPro Entry P35869

    ProtoNet protein and cluster: P35869

    3 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB001610 PAC motif
    IPB013655 PAS fold-3


    UniProtKB/Swiss-Prot: AHR_HUMAN, P35869
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
    Similarity: Contains 2 PAS (PER-ARNT-SIM) domains


    AHR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AHR_HUMAN, P35869
    Function: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates.
    Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the
    CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle
    regulation. Likely to play an important role in the development and maturation of many tissues
    Induction: Induced or repressed by TGFB1 and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic
    acid, and 12-O-tetradecanoyl phorbol-13 acetate (TPA)

         Genatlas biochemistry entry for AHR:
    aryl hydrocarbon receptor,unliganded,retained in cytoplasm in resting state in association with HSP90,and with AIP
    (AH receptor associated protein 9),released after exposure to xenobiotics,dimerizing with ARNT and translocated
    to the nucleus interacting with pRB1 to induce G1 arrest

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS19538249
    GO:0003700sequence-specific DNA binding transcription factor activity IDA11782478
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA--
    GO:0004871signal transducer activity ----
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IDA10395741
         
    AHR for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AHR:
     Increased cell death HMECs cel 

         15/18 MGI mutant phenotypes (inferred from 12 alleles(MGI details for Ahr) (see all 18):
     cardiovascular system  digestive/alimentary  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     muscle  no phenotypic analysis  renal/urinary system  reproductive system  respiratory system 

    AHR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for AHR: Ahrtm1Gonz Ahrtm1Bra

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AHR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AHR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AHR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AHR 

    10/940 SABiosciences Target genes for AHR (see all 940):
    AASDHPPT ABCC12 ABCG1 ABLIM1 ACAD8 ACCS ACN9 ACO2 ACTL6A ACTN1

    miRNA
    Products:
        
    miRTarBase miRNAs that target AHR:
    hsa-mir-124 (MIRT002653)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AHR
    8/63 QIAGEN miScript miRNA Assays for microRNAs that regulate AHR (see all 63):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-29a hsa-miR-219-5p hsa-miR-502-3p hsa-miR-548l hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidAHR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AHR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AHR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AHR
    Sirion Biotech Customized adenovirus for overexpression of AHR

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for AHR (see all 7)
    OriGene ORF clones in mouse, rat for AHR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AHR (NM_001621)
    Sino Biological Human cDNA Clone for AHR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AHR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHR
    Sirion Biotech Customized lentivirus for stable overexpression of AHR 
                         Customized lentivirus expression plasmids for stable overexpression of AHR 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AHR
    Search LifeMap BioReagents cell lines for AHR
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AHR About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PKA activation in glucagon signalling
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.38
    2AhR pathway
    AhR pathway
    3Adipogenesis
    Adipogenesis
    4AHR Pathway
    AHR Pathway
    5Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AHR
        AHR Pathway

    1 GeneGo (Thomson Reuters) Pathway for AHR
        Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling

    3 BioSystems Pathways for AHR
        Adipogenesis
    Integrated Breast Cancer Pathway
    AhR pathway



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AHR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for AHR (P358691, 3 ENSP000002420574) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARNTP275401, 3, ENSP000003514074EBI-80780,EBI-80809 I2D: score=10 STRING: ENSP00000351407
    NCOR2Q9Y6181, 3, ENSP000003485514EBI-80780,EBI-80830 I2D: score=2 STRING: ENSP00000348551
    NCOA7Q8NI081, 3, ENSP000003573414EBI-80780,EBI-80799 I2D: score=1 STRING: ENSP00000357341
    NCOA2Q155963, ENSP000003999684I2D: score=4 STRING: ENSP00000399968
    CCNT1O605633, ENSP000002619004I2D: score=3 STRING: ENSP00000261900
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001568blood vessel development NAS19538249
    GO:0006355regulation of transcription, DNA-dependent IDA10395741
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA15681594
    GO:0006366transcription from RNA polymerase II promoter IDA10395741

    AHR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AHR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for AHR

    Compounds for AHR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CH 223191Potent aryl hydrocarbon receptor (AhR) antagonist[301326-22-7]
    DiMNFSelective aryl hydrocarbon receptor modulator (SAhRM)[14756-24-2]

    1 HMDB Compound for AHR    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    6 DrugBank Compounds for AHR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Atorvastatin-- 134523-00-5targetagonist23703578 17327465
    LeflunomideLeflunomidum [INN-Latin] (see all 2)75706-12-6targetagonist20957046 17327465
    Flutamide-- 13311-84-7targetagonist17327465
    Ginseng-- 50647-08-0targetagonist19022240
    MexiletineMexiletina [INN-Spanish] (see all 4)31828-71-4targetagonist17327465
    NimodipineNimodipino [INN-Spanish] (see all 2)66085-59-4targetagonist17327465

    10/109 Novoseek inferred chemical compound relationships for AHR gene (see all 109)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tcdd 97.6 1250 10777561 (7), 16613807 (6), 19056653 (6), 9415701 (5) (see all 99)
    alpha-naphthoflavone 89.6 129 8385898 (4), 8390116 (3), 16569260 (2), 10630576 (2) (see all 55)
    indolo(3,2-b)carbazole 86.3 19 7966413 (3), 15917307 (2), 18219281 (2), 18762178 (1) (see all 7)
    hydrocarbons 85.3 119 12673023 (3), 8697610 (1), 9415701 (1), 18950284 (1) (see all 94)
    3-methylcholanthrene 85.2 127 8163517 (4), 19270430 (4), 1654865 (4), 16257430 (4) (see all 46)
    benzo(a)pyrene 84.7 196 18372000 (4), 19559082 (4), 10230769 (4), 17376491 (3) (see all 78)
    pcb 126 83.6 12 18155262 (2), 17512696 (2), 14962508 (1), 16396990 (1) (see all 6)
    2-azido-3-(125i)iodo-7,8-dibromodibenzo-p-dioxin 82.3 2 15213304 (1), 1846218 (1)
    mcdf 81.9 15 15087408 (2), 15026081 (2), 10822009 (1), 7821706 (1) (see all 7)
    beta-naphthoflavone 81.2 60 8385898 (5), 20060304 (2), 11595506 (2), 14751679 (1) (see all 30)

    Search CenterWatch for drugs/clinical trials and news about AHR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AHR gene: 
    NM_001621.4  

    Unigene Cluster for AHR:

    Aryl hydrocarbon receptor
    Hs.171189  [show with all ESTs]
    Unigene Representative Sequence: NM_001621
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000242057(uc011jxz.1) ENST00000463496 ENST00000475440 ENST00000481944
    ENST00000492120
    miRNA
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    8/63 QIAGEN miScript miRNA Assays for microRNAs that regulate AHR (see all 63):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-29a hsa-miR-219-5p hsa-miR-502-3p hsa-miR-548l hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidAHR 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AHR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AHR
    Clone
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    OriGene clones in human, mouse for AHR (see all 7)
    OriGene ORF clones in mouse, rat for AHR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AHR (NM_001621)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AHR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHR
    Sirion Biotech Customized lentivirus for stable overexpression of AHR 
                         Customized lentivirus expression plasmids for stable overexpression of AHR 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AHR
    OriGene qSTAR qPCR primer pairs in human, mouse for AHR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AHR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AHR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AHR

    Additional mRNA sequence: 

    AK130815.1 AK307495.1 BC021696.1 BC069390.1 BC070080.1 D16354.1 

    9 DOTS entries:

    DT.454488  DT.100654226  DT.92428380  DT.97831966  DT.100654222  DT.100654223  DT.100654220  DT.100654225 
    DT.91664671 

    24/208 AceView cDNA sequences (see all 208):

    BX505160 AI306430 BC021696 AI537555 N90226 D16354 BQ025841 AI986448 
    BP337076 CN483485 BC070080 BQ024331 AI860369 BX957133 CD516264 AI361164 
    BM955721 BU149806 H77929 AU185443 BC069390 BG178882 AI082089 BQ719892 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AHR expression in normal human tissues (normalized intensities)      AHR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATAGATTTT
    AHR Expression
    About this image


    AHR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
             Ureter
             visceral organ/urethra of female/pelvic urethra of female   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Rod Cells Outer Nuclear Layer
             optic nerve head astrocytes   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             optic nerve head astrocytes   
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain

    See AHR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AHR

    SOURCE GeneReport for Unigene cluster: Hs.171189

    UniProtKB/Swiss-Prot: AHR_HUMAN, P35869
    Tissue specificity: Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas
    and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including AHR (see all 8): 
              Nuclear Receptors & Coregulators in human mouse rat
              Drug Metabolism in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              WNT Signaling Targets in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for AHR gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ahr1 , 5 aryl-hydrocarbon receptor1, 5 79.17(n)1
    74.62(a)1
      12 (15.78 cM)5
    116221  NM_013464.41  NP_038492.11 
     354979745 
    chicken
    (Gallus gallus)
    Aves AHR1 aryl hydrocarbon receptor 72.16(n)
    67.96(a)
      373907  NM_204118.1  NP_989449.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia AHR2 aryl hydrocarbon receptor 75.09(n)    AB109555.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ahr12 aryl hydrocarbon receptor 1 73.28(n)   246224  AF258854.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ss3 transcription from Pol II promoter
    transcription more
    45(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea ahr-13 aryl hydrocarbon (AH) receptor 34(a)   I(9530635-9539155)   --


    ENSEMBL Gene Tree for AHR (if available)
    TreeFam Gene Tree for AHR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AHR gene
    AHRR2  

    AHR for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for AHR
    PGOHUM00000243513


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/927 SNPs in AHR are shown (see all 927)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429231571,2
    --17336396(+) ATCCTA/CAACTT 1 -- us2k10--------
    rs1865483811,2
    --17336493(+) TTTTTA/TAAATC 1 -- us2k10--------
    rs1923315571,2
    --17336521(+) TCATTA/GCATTT 1 -- us2k10--------
    rs357034841,2
    C,F--17336597(+) TTTTTC/AACCCT 1 -- us2k15Minor allele frequency- A:0.01MN 392
    rs1819720321,2
    --17336643(+) ACTTAC/GACGTT 1 -- us2k10--------
    rs1480993231,2
    --17336912(+) ATCTAC/TTTCCT 1 -- us2k10--------
    rs736806531,2
    C,F--17337165(+) TCCTGT/CGAACT 1 -- us2k12Minor allele frequency- C:0.08WA 120
    rs1851671281,2
    --17337316(+) TTATGC/TTTTGG 1 -- us2k10--------
    rs1122830151,2
    F--17337343(+) CTTTCG/AGTATC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1898340391,2
    --17337375(+) CTCTTC/GCCTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AHR (17338246 - 17385776 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for AHR (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422294CNV Duplication17116639
    nsv887793CNV Loss21882294
    nsv887792CNV Loss21882294
    nsv464399CNV Gain19166990
    dgv7217n71CNV Gain21882294
    dgv7220n71CNV Gain21882294
    esv34717CNV Gain17911159
    nsv464398CNV Gain19166990
    nsv8064CNV Gain18304495
    essv2917CNV CNV17122850


    Human Gene Mutation Database (HGMD): AHR
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600253    OMIM disorders: --

    20/79 diseases for AHR (see all 79):    About MalaCards
    toxic oil syndrome    hepatitis b    eosinophilic fasciitis    hydronephrosis
    choriocarcinoma    clear cell adenocarcinoma    ovarian clear cell adenocarcinoma    fasciitis
    endometriosis    porphyria    placental choriocarcinoma    porphyria cutanea tarda
    mucinous adenocarcinoma    ovarian endometriosis    endocervicitis    hepatoblastoma
    breast adenocarcinoma    colon adenocarcinoma    hepatitis    adrenocortical carcinoma

    4 diseases from the University of Copenhagen DISEASES database for AHR:
    Hepatocellular carcinoma     Hydronephrosis     Breast cancer     Cleft palate

    AHR for disorders           About GeneDecksing

    10/56 Novoseek inferred disease relationships for AHR gene (see all 56)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ahh inducibility 60.8 1 7550366 (1)
    breast cancer 58.8 101 11408954 (4), 11179685 (3), 11114727 (3), 10922479 (2) (see all 64)
    chemical carcinogenesis 45.4 2 15794642 (1), 12369945 (1)
    mammary tumor 43.7 15 16972784 (2), 7966413 (1), 11179685 (1), 14973392 (1) (see all 11)
    cancer 33.7 50 19690180 (4), 15028720 (2), 19015043 (2), 8395783 (2) (see all 29)
    adenocarcinoma lung 31.8 19 19358281 (6), 17200336 (5), 14644512 (1), 17127240 (1)
    porphyria 23 9 18163543 (2), 11854449 (1), 9918132 (1), 8638948 (1)
    colon adenocarcinoma 22.1 3 16115717 (1), 8163517 (1), 1654865 (1)
    micropenis 22 1 15758562 (1)
    endometriosis 21.5 12 16084889 (4), 10724351 (4), 12200463 (1), 11393538 (1) (see all 5)

    Genetic Association Database (GAD): AHR
    Human Genome Epidemiology (HuGE) Navigator: AHR (92 documents)

    Export disorders for AHR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AHR gene, integrated from 9 sources (see all 1077):
    (articles sorted by number of sources associating them with AHR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer. (PubMed id 11698344)1, 2, 4, 9 Cauchi S.... Massaad-Massade L. (2001)
    2. Analysis of the AhR, ARNT, and AhRR gene polymorphisms: genetic contribution to endometriosis susceptibility and severity. (PubMed id 16084889)1, 4, 9 Tsuchiya M.... Ikenoue T. (2005)
    3. Genetic polymorphisms and transcriptional pattern analysis of CYP1A1, AhR, GSTM1, GSTP1 and GSTT1 genes in breast cancer. (PubMed id 11408954)1, 4, 9 Dialyna I.A....Spandidos D.A. (2001)
    4. The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility. (PubMed id 17559847)1, 4, 9 Merisalu A....Salumets A. (2007)
    5. Interaction between organochlorines and the AHR gene, and risk of non-Hodgkin lymphoma. (PubMed id 19821039)1, 4, 9 Ng C.H....Spinelli J.J. (2010)
    6. Association of polymorphisms in AhR, CYP1A1, GSTM1, and GSTT1 genes with levels of DNA damage in peripheral blood lymphocytes among coke-oven workers. (PubMed id 16985033)1, 4, 9 Chen Y....Wu T. (2006)
    7. Polymorphism of alpha-estrogen receptor and aryl hydrocarbon receptor genes in dementia patients in Shanghai suburb. (PubMed id 12852830)1, 4, 9 Lin G.F....Shen J.H. (2003)
    8. Human arylhydrocarbon receptor repressor (AHRR) gene: genomic structure and analysis of polymorphism in endometriosis. (PubMed id 11393538)1, 4, 9 Watanabe T....Inazawa J. (2001)
    9. Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. (PubMed id 10739168)1, 2, 9 Smart J. and Daly A.K. (2000)
    10. Interindividual difference in expression of human Ah receptor and related P450 genes. (PubMed id 7515333)1, 2, 9 Hayashi S.... Kawajiri K. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 196 HGNC: 348 AceView: AHR Ensembl:ENSG00000106546 euGenes: HUgn196
    ECgene: AHR H-InvDB: AHR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AHR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AHR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AHR gene:
    Search GeneIP for patents involving AHR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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