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Aliases & Descriptions for AHR
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| AH-receptor 2 | | AhR 3 | | BHLHE76 3 | | bHLHe76 1, 2, 3 |
| | | Descriptions |
|---|
| Ah receptor 3 | | Class E basic helix-loop-helix protein 76 3 | | aromatic hydrocarbon receptor 2 | | aryl hydrocarbon receptor 2 |
|
| | Search outside databases for aliases for AHR genePrevious GC identifers: GC07P016982 GC07P017082 GC07P017111 |
Summaries for AHR(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for AHR: This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. [provided by RefSeq] UniProtKB/Swiss-Prot: AHR_HUMAN, P35869Function: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissuesGene Wiki entry for AHR (Aryl_hydrocarbon_receptor) |
Genomic Location for AHR
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the AHR gene 
Entrez Gene cytogenetic band: 7p15 Ensembl cytogenetic band: 7p21.1 HGNC cytogenetic band: 7p15AHR Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P017304:
(about GC identifiers)
Start:
|
17,304,832 bp from pter |
End:
|
17,352,299 bp from pter |
Size:
|
47,468 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 17,391,703-17,439,184 |
RefSeq DNA sequence:- NC_000007.12 NT_007819.16 NT_079592.2
| Proteins for AHR
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: AHR_HUMAN, P35869 (See
protein sequence)Recommended Name: Aryl hydrocarbon receptor precursor Size: 848 amino acids; 96147 Da
Subunit: Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP
Subcellular location: Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus
Secondary accessions: Q13728 Q13803 Q13804Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001612.1
ENSEMBL proteins: ENSP00000385642 ENSP00000242057
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for AHR: Assays for AHR: | Protein
Domains/ Families for AHR(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P35869
ProtoNet protein and cluster: P35869 3 Blocks protein families: IPB001092 Basic helix-loop-helix dimerization domain bHLH IPB001610 PAC motif IPB013655 PAS fold-3
UniProtKB/Swiss-Prot: AHR_HUMAN, P35869Similarity: Contains 1 basic helix-loop-helix (bHLH) domainSimilarity: Contains 1 PAC (PAS-associated C-terminal) domainSimilarity: Contains 2 PAS (PER-ARNT-SIM) domains | Gene Function for AHR
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001621
Applied Biosystems Silencer® siRNAs for AHR
Sigma-Aldrich siRNA and siRNA Panels for AHR  Sigma-Aldrich shRNA for AHR  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001621                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001621                                  untagged cDNA clone in CMV expression vector: NM_001621 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001621
UniProtKB/Swiss-Prot: AHR_HUMAN, P35869Function: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissuesInduction: Induced or repressed by TGF-beta and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic acid, and TPAGenatlas biochemistry entry for AHR:aryl hydrocarbon receptor,unliganded,retained in cytoplasm in resting state in association with HSP90,and with AIP (AH receptor associated protein 9),released after exposure to xenobiotics,dimerizing with ARNT and translocated to the nucleus interacting with pRB1 to induce G1 arrest15 MGI mutant phenotypes (inferred from 12 alleles ) (MGI details for Ahr):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for AHR
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for AHR (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for AHR 
5/75 Interacting proteins for AHR (ENSP000002420573 P358691) via UniProtKB, MINT, and/or STRING (see all 75
)About this table
5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8
): About this table
|
Drugs & Compounds for AHR(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for AHR |
Compounds for AHR available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| ITE | Endogenous agonist for the transcription factor aryl hydrocarbon receptor | [448906-42-1] | | Pifithrin-alpha hydrobromide | p53 inhibitor. Also aryl hydrocarbon receptor agonist | [63208-82-2] | About this table
10/46 Novoseek chemical compound relationships for AHR gene (see all 46
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tcdd |
97.64 |
1159 |
10777561 (7), 16613807 (6), 19056653 (6), 9415701 (5) (see all 99) |
| alpha-naphthoflavone |
89.49 |
126 |
8385898 (4), 8390116 (3), 16569260 (2), 10630576 (2) (see all 52) |
| indolo(3,2-b)carbazole |
86.38 |
14 |
7966413 (3), 15917307 (2), 18219281 (2), 18762178 (1) (see all 6) |
| hydrocarbons |
85.01 |
113 |
12673023 (3), 8697610 (1), 9415701 (1), 18950284 (1) (see all 89) |
| 3-methylcholanthrene |
84.41 |
108 |
8163517 (4), 19270430 (4), 1654865 (4), 16257430 (4) (see all 40) |
| benzo(a)pyrene |
83.55 |
157 |
18372000 (4), 10230769 (4), 17376491 (3), 17944540 (3) (see all 66) |
| mcdf |
82.56 |
15 |
15087408 (2), 15026081 (2), 10822009 (1), 7821706 (1) (see all 7) |
| 2-azido-3-(125i)iodo-7,8-dibromodibenzo-p-dioxin |
80.44 |
2 |
15213304 (1), 1846218 (1) |
| dibenzofurans |
79.62 |
22 |
12650590 (2), 8697610 (1), 18757099 (1), 8597135 (1) (see all 18) |
| tcdf |
79.38 |
11 |
7840604 (1), 9501000 (1), 10387926 (1), 11032772 (1) (see all 7) |
About this table
|
Transcripts for AHR(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001621
Sigma-Aldrich siRNA and siRNA Panels for AHR  Sigma-Aldrich shRNA for AHR  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001621 REFSEQ mRNAs for AHR gene: NM_001621.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001621               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001621                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001621                                  untagged cDNA clone in CMV expression vector: NM_001621  Additional cDNA sequence: AK130815.1 AK307495.1 BC021696.1 BC069390.1 BC070080.1 D16354.1 9 DOTS entries: DT.454488 DT.100654226 DT.97831966 DT.100654223 DT.92428380 DT.100654220 DT.100654222 DT.100654225 DT.91664671 24/208 AceView cDNA sequences (see all 208
):BX957133 CB216067 BX283596 N90226 BC070080 AI986448 AU185443 BM955721 CD516264 AI537555 BQ024331 AI361164 BU149806 AI082089 CB116426 AI306430 H77929 CA412565 BG178882 AI422236 AI801360 CN483485 D16354 BM724349
highest scoring ESTs for AHR:AA757081 AI082089 AI358935 AL705131 AW169675 AW362856 AW600918 AW600935 BC069390 BF126553 Unigene Cluster for AHR: Aryl hydrocarbon receptor Hs.171189 [show with all ESTs]Unigene Representative Sequence: NM_001621
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000401808
ENST00000242057
|
Expression for AHR
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| AHR expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for AHR
1 / 2 / 3 3 probe-sets matching AHR gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CATAGATTTT
SOURCE GeneReport for Unigene cluster: Hs.171189
Expression variation in blood from EXPOLDB for AHR UniProtKB/Swiss-Prot: AHR_HUMAN, P35869Tissue specificity: Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle |
Orthologs for AHR
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AHR gene from 5/11 species (see all 11
)
About this table Species with no ortholog for AHR
ENSEMBL Gene Tree for AHR | Paralogs for AHR(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for AHR gene
- AHRR2
|
SNPs/Variants for AHR(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for AHR (up to first 250kb)
|
Disorders & Mutations for AHR
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 600253
10/54 Novoseek disease relationships for AHR gene (see all 54
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ahh inducibility |
61.77 |
1 |
7550366 (1) |
| breast cancer |
58.84 |
94 |
11408954 (4), 11179685 (3), 11114727 (3), 10922479 (2) (see all 60) |
| mammary tumor |
45.68 |
15 |
16972784 (2), 7966413 (1), 11179685 (1), 14973392 (1) (see all 11) |
| chemical carcinogenesis |
43.57 |
2 |
15794642 (1), 12369945 (1) |
| adenocarcinoma lung |
31.60 |
12 |
17200336 (5), 14644512 (1), 17127240 (1) |
| cancer |
30.52 |
39 |
15028720 (2), 19015043 (2), 8395783 (2), 8921980 (2) (see all 22) |
| porphyria |
24.70 |
9 |
18163543 (2), 11854449 (1), 9918132 (1), 8638948 (1) |
| micropenis |
24.46 |
1 |
15758562 (1) |
| endometriosis |
24.30 |
12 |
16084889 (4), 10724351 (4), 12200463 (1), 11393538 (1) (see all 5) |
| colon adenocarcinoma |
24.25 |
3 |
16115717 (1), 8163517 (1), 1654865 (1) |
About this table
Human Gene Mutation Database: AHR Genetic Association Database: AHR Human Genome Epidemiology Navigator: AHR (66 documents)
|
Medical News for AHR(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications for AHR (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/830 PubMed articles for AHR gene (see all 830
):- Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer. (PubMed id 11698344)1, 3, 4, 6 Cauchi S.... Massaad-Massade L. (2001)
- Analysis of the AhR, ARNT, and AhRR gene polymorphisms: genetic contribution to endometriosis susceptibility and severity. (PubMed id 16084889)1, 3, 6 Tsuchiya M.... Ikenoue T. (2005)
- Interindividual difference in expression of human Ah receptor and related P450 genes. (PubMed id 7515333)1, 3, 4 Hayashi S.... Kawajiri K. (1994)
- Genetic polymorphisms and transcriptional pattern analysis of CYP1A1, AhR, GSTM1, GSTP1 and GSTT1 genes in breast cancer. (PubMed id 11408954)1, 3, 6 Dialyna I.A....Spandidos D.A. (2001)
- Polymorphism of alpha-estrogen receptor and aryl hydrocarbon receptor genes in dementia patients in Shanghai suburb. (PubMed id 12852830)1, 3, 6 Lin G.F....Shen J.H. (2003)
- Human arylhydrocarbon receptor repressor (AHRR) gene: genomic structure and analysis of polymorphism in endometriosis. (PubMed id 11393538)1, 3, 6 Watanabe T....Inazawa J. (2001)
- Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. (PubMed id 10739168)1, 3, 4 Smart J. and Daly A.K. (2000)
- Association of micropenis with Pro185Ala polymorphism of the gene for aryl hydrocarbon receptor repressor involved in dioxin signaling. (PubMed id 15758562)1, 3, 6 Soneda S....Ogata T. (2005)
- Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study. (PubMed id 16103451)1, 3, 6 Le Marchand L....Wilkens L.R. (2005)
- Role of the aryl hydrocarbon receptor in cell cycle regulation. (PubMed id 12213388)1, 3, 4 Puga A.... Elferink C. (2002)
|
Search for AHR
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing AHR
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing AHR
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AHR(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for AHR(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for AHR:

 | |
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|
 |  |  |
| | | | Tocris compounds for AHR |
|
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 | | | Antibodies for AHR |
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Incremental update: 13 Oct 2009
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