AHR Gene
protein-coding GIFtS : 67
GCID: GC07 P017304
aryl hydrocarbon receptor
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Aliasesfor AHR gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Aryl Hydrocarbon Receptor 1 2 AH-Receptor1 BHLHe761 Aromatic Hydrocarbon Receptor2 Ah Receptor2 3 AhR3 Class E Basic Helix-Loop-Helix Protein 762 3 BHLHE763
Export aliases for AHR gene to outside databases Previous GC identifers: GC07P016982 GC07P017082 GC07P017111 GC07P017224
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Summariesfor AHR gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for AHR : This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: AHR_HUMAN, P35869 Function : Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activatesthe expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues summary
for AHR : Aryl hydrocarbon receptors (AHRs) are cytosolic transcription factors that exist bound to co-chaperones inthe resting state (Hsp90, prostaglandin E synthase 3 and hepatitis B virus X-associated protein 2). Ligandbinding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize withAHR nuclear translocator (ARNT) and alter transcription of target genes. AHR is an evolutionary conservedreceptor that has roles in cell proliferation and differentiation and induction of xenobiotic-metabolizingenzymes (for example CYP1A1). The human gene encoding the aryl hydrocarbon receptor has been localized tochromosome 7p15. Gene Wiki entry for AHR (Aryl hydrocarbon receptor) PharmGKB "VIP " summary for
AHR
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Genomic Viewsfor AHR gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the AHR gene promoter: GR Max1 Sp1 HNF-3beta PPAR-gamma1 PPAR-gamma2 GR-alpha c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for AHR Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat AHR
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7p15 Ensembl cytogenetic band: 7p21.1 HGNC cytogenetic band: 7p15 AHR Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07P017304: view genomic region
(about GC identifiers )
Start:
17,338,246 bp from pter
End:
17,385,776 bp from pter
Size:
47,531 bases
Orientation:
plus strand
1 alternative location : Chr 7+,CRA_TCAG 17,391,672-17,439,185
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Proteinsfor AHR gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: AHR_HUMAN, P35869 (See
protein sequence )Recommended Name: Aryl hydrocarbon receptor precursor Size : 848 amino acids; 96147 Da
Subunit : Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. In thenucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP
Subcellular location : Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with aHSP90, it translocates to the nucleus
Secondary accessions : A4D130 Q13728 Q13803 Q13804Explore the universe of human proteins at neXtProt for AHR: NX_P35869 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P35869 AHR Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_001612.1 ENSEMBL proteins: ENSP00000242057 ENSP00000436466 Human Recombinant Protein Products: Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6 ): About this table
AHR for ontologies About GeneDecksing AHR Antibody Products: Assay Products for AHR:
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Protein
Domains / Familiesfor AHR gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
AHR for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P35869 ProtoNet protein and cluster: P35869
3 Blocks protein families : IPB001092 Basic helix-loop-helix dimerization domain bHLH IPB001610 PAC motif IPB013655 PAS fold-3 UniProtKB/Swiss-Prot: AHR_HUMAN, P35869 Similarity : Contains 1 bHLH (basic helix-loop-helix) domainSimilarity : Contains 1 PAC (PAS-associated C-terminal) domainSimilarity : Contains 2 PAS (PER-ARNT-SIM) domains
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Functionfor AHR gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: AHR_HUMAN, P35869 Function : Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activatesthe expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues Induction : Induced or repressed by TGFB1 and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic acid,and 12-O-tetradecanoyl phorbol-13 acetate (TPA)
Genatlas biochemistry entry for AHR : aryl hydrocarbon receptor,unliganded,retained in cytoplasm in resting state in association with HSP90,and with AIP (AH receptor associated protein 9),released after exposure to xenobiotics,dimerizing with ARNT and translocated to the nucleus interacting with pRB1 to induce G1 arrest Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AHR (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AHROriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: AHR (NM_001621 ) Sino Biological Human cDNA Clone for AHR DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AHR Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AHR
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHR
Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding
TAS 19538249 GO:0003700 sequence-specific DNA binding transcription factor activity
IDA 11782478 GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
IEA -- GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
IDA 10395741 GO:0005515 protein binding
IPI 9079689
AHR for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for AHR :Animal Models: Mouse knock-outs for AHR: Ahr tm1Gonz Ahr tm1Bra 15/18 MGI mutant phenotypes (inferred from 12 alleles ) (MGI details for Ahr) (see all 18 ):
AHR for phenotypes About GeneDecksing
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Pathways & Interactionsfor AHR gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 AHR Pathway 2 Adipogenesis 3 Integrated Breast Cancer Pathway 4 PKA activation in glucagon signalling
Pathway sources See GeneCards unified pathways Show all pathways 1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AHR 1 GeneGo (Thomson Reuters) Pathway for AHR 2 BioSystems Pathways for AHR Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AHR STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/49 Interacting proteins for AHR (P35869 1 , 3 ENSP00000242057 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 49 )Interactant Interaction Details GeneCard External ID(s) ARNT P27540 1 , 3 , ENSP00000351407 4 EBI-80780,EBI-80809 I2D:
score=10 STRING: ENSP00000351407 NCOR2 Q9Y618 1 , 3 , ENSP00000348551 4 EBI-80780,EBI-80830 I2D:
score=2 STRING: ENSP00000348551 NCOA7 Q8NI08 1 , 3 , ENSP00000357341 4 EBI-80780,EBI-80799 I2D:
score=1 STRING: ENSP00000357341 NCOA2 Q15596 3 , ENSP00000399968 4 I2D:
score=4 STRING: ENSP00000399968 CCNT1 O60563 3 , ENSP00000261900 4 I2D:
score=3 STRING: ENSP00000261900
About this table Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22 ): About this table
AHR for ontologies About GeneDecksing
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Drugs & Compoundsfor AHR gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
AHR for compounds About GeneDecksing
Enzo Life Sciences drugs & compounds for AHR
Compounds for AHR available from Tocris Bioscience About this table Compound Action
CAS
# L-Kynurenine Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand [2922-83-0] ITE Endogenous agonist for the transcription factor aryl hydrocarbon receptor [448906-42-1] Pifithrin-alpha hydrobromide p53 inhibitor. Also aryl hydrocarbon receptor agonist [63208-82-2] 6,2',4'-Trimethoxyflavone Aryl hydrocarbon receptor antagonist --
1 HMDB Compound for AHR About this table 6 DrugBank Compounds for AHR About this table 10/109 Novoseek chemical compound relationships for AHR gene (see all 109 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
tcdd
97.6
1250
10777561 (7), 16613807 (6), 19056653 (6), 9415701 (5) (see all 99 )
alpha-naphthoflavone
89.6
129
8385898 (4), 8390116 (3), 16569260 (2), 10630576 (2) (see all 55 )
indolo(3,2-b)carbazole
86.3
19
7966413 (3), 15917307 (2), 18219281 (2), 18762178 (1) (see all 7 )
hydrocarbons
85.3
119
12673023 (3), 8697610 (1), 9415701 (1), 18950284 (1) (see all 94 )
3-methylcholanthrene
85.2
127
8163517 (4), 19270430 (4), 1654865 (4), 16257430 (4) (see all 46 )
benzo(a)pyrene
84.7
196
18372000 (4), 19559082 (4), 10230769 (4), 17376491 (3) (see all 78 )
pcb 126
83.6
12
18155262 (2), 17512696 (2), 14962508 (1), 16396990 (1) (see all 6 )
2-azido-3-(125i)iodo-7,8-dibromodibenzo-p-dioxin
82.3
2
15213304 (1), 1846218 (1)
mcdf
81.9
15
15087408 (2), 15026081 (2), 10822009 (1), 7821706 (1) (see all 7 )
beta-naphthoflavone
81.2
60
8385898 (5), 20060304 (2), 11595506 (2), 14751679 (1) (see all 30 )
Search CenterWatch for drugs/clinical trials and news about AHR
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Transcriptsfor AHR gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for AHR gene: NM_001621.4 Unigene Cluster for AHR:
Aryl hydrocarbon receptor Hs.171189 [show with all ESTs ] Unigene Representative Sequence: NM_001621 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000242057 (uc011jxz.1 ) ENST00000463496 ENST00000475440 ENST00000481944 ENST00000492120 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AHR (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AHROriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: AHR (NM_001621 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AHR Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AHR
Additional cDNA sequence: AK130815.1 AK307495.1 BC021696.1 BC069390.1 BC070080.1 D16354.1
9 DOTS entries : DT.454488 DT.100654226
DT.92428380 DT.97831966 DT.100654222 DT.100654223 DT.100654225 DT.100654220 DT.91664671 24/208 AceView cDNA sequences (see all 208 ):
CB216067 BC069390 AI306430 AI986448 H77668 BM724349 CA412565 D16354 BQ719892 BC021696 BX283596 BM955721 CB116426 AI361164 N90226 BQ025841 BU149806 CD516264 AU185443 BP337076 BG178882 AI537555 BC070080 CN483485 GeneLoc Exon Structure
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Expression for AHR gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section AHR expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CATAGATTTT
About this image AHR expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See AHR Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for AHR SOURCE GeneReport for Unigene cluster: Hs.171189 UniProtKB/Swiss-Prot: AHR_HUMAN, P35869 Tissue specificity : Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas andskeletal muscle SABiosciences Expression via Pathway-Focused PCR Arrays including AHR (see all 8 ): Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for AHRBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat AHR QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat AHR QIAGEN QuantiFast Probe-based Assays in human , mouse , rat AHR In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHR
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Orthologsfor AHR gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for AHR gene from 5/21 species (see all 21 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
AHR1
aryl hydrocarbon receptor
72.16(n) 67.96(a)
 
373907 NM_204118.1 NP_989449.1
African clawed frog (Xenopus laevis)
Amphibia
AHR2
aryl hydrocarbon receptor
75.09(n)
 
AB109555.1
zebrafish (Danio rerio)
Actinopterygii
ahr12
aryl hydrocarbon receptor 1
73.28(n)
 
246224 AF258854.1
fruit fly (Drosophila melanogaster)
Insecta
ss3
transcription from Pol II promoter transcription more
45(a)
 
--
worm (Caenorhabditis elegans)
Secernentea
ahr-13
aryl hydrocarbon (AH) receptor
34(a)
 
I(9530635-9539155) --
ENSEMBL Gene Tree for AHR (if available)TreeFam Gene Tree for AHR (if available)
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Paralogsfor AHR gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for AHR gene AHRR 2
AHR for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for AHR PGOHUM00000243513
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Genomic Variantsfor AHR gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 7 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for AHR (17338246 - 17385776 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 5 variations for AHR 5 CNVs : 5236 8551 2685 3668 31337 Human Gene Mutation Database (HGMD) : AHR SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing AHR
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Disorders
/ Diseasesfor AHR gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
AHR for disorders About GeneDecksing
OMIM gene information: 600253
OMIM disorders : --20/90 diseases for AHR (see all 90 ): About MalaCards hepatitis b porphyria cutanea tarda age related macular degeneration hepatitis non-small cell lung carcinoma eosinophilic fasciitis non-hodgkin lymphoma clear cell adenocarcinoma micropenis soft tissue sarcoma seborrheic dermatitis iron overload ovarian clear cell adenocarcinoma hydronephrosis porphyria macular degeneration placental choriocarcinoma fasciitis oral squamous cell carcinoma squamous cell carcinoma 10/56 Novoseek disease relationships for AHR gene (see all 56 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
ahh inducibility
60.8
1
7550366 (1)
breast cancer
58.8
101
11408954 (4), 11179685 (3), 11114727 (3), 10922479 (2) (see all 64 )
chemical carcinogenesis
45.4
2
15794642 (1), 12369945 (1)
mammary tumor
43.7
15
16972784 (2), 7966413 (1), 11179685 (1), 14973392 (1) (see all 11 )
cancer
33.7
50
19690180 (4), 15028720 (2), 19015043 (2), 8395783 (2) (see all 29 )
adenocarcinoma lung
31.8
19
19358281 (6), 17200336 (5), 14644512 (1), 17127240 (1)
porphyria
23
9
18163543 (2), 11854449 (1), 9918132 (1), 8638948 (1)
colon adenocarcinoma
22.1
3
16115717 (1), 8163517 (1), 1654865 (1)
micropenis
22
1
15758562 (1)
endometriosis
21.5
12
16084889 (4), 10724351 (4), 12200463 (1), 11393538 (1) (see all 5 )
Genetic Association Database (GAD): AHR Human Genome Epidemiology (HuGE) Navigator: AHR (92 documents) Export disorders for AHR gene to outside databases
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Publicationsfor AHR gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for AHR gene, integrated from 9 sources (see all 1050 ): (articles sorted by number of sources associating them with AHR) Utopia : connect your pdf to the dynamic world of online information
Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer. (PubMed id 11698344) 1 , 2 , 4, 9 Cauchi S.... Massaad-Massade L. (2001) Analysis of the AhR, ARNT, and AhRR gene polymorphisms: genetic contribution to endometriosis susceptibility and severity. (PubMed id 16084889) 1 , 4, 9 Tsuchiya M.... Ikenoue T. (2005) Genetic polymorphisms and transcriptional pattern analysis of CYP1A1, AhR, GSTM1, GSTP1 and GSTT1 genes in breast cancer. (PubMed id 11408954) 1 , 4, 9 Dialyna I.A....Spandidos D.A. (2001) Polymorphism of alpha-estrogen receptor and aryl hydrocarbon receptor genes in dementia patients in Shanghai suburb. (PubMed id 12852830) 1 , 4, 9 Lin G.F....Shen J.H. (2003) Human arylhydrocarbon receptor repressor (AHRR) gene: genomic structure and analysis of polymorphism in endometriosis. (PubMed id 11393538) 1 , 4, 9 Watanabe T....Inazawa J. (2001) Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. (PubMed id 10739168) 1 , 2 , 9 Smart J. and Daly A.K. (2000) Interindividual difference in expression of human Ah receptor and related P450 genes. (PubMed id 7515333) 1 , 2 , 9 Hayashi S.... Kawajiri K. (1994) Association of micropenis with Pro185Ala polymorphism of the gene for aryl hydrocarbon receptor repressor involved in dioxin signaling. (PubMed id 15758562) 1 , 4, 9 Soneda S....Ogata T. (2005) Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study. (PubMed id 16103451) 1 , 4, 9 Le Marchand L....Wilkens L.R. (2005) Role of the aryl hydrocarbon receptor in cell cycle regulation. (PubMed id 12213388) 1 , 2 , 9 Puga A.... Elferink C. (2002)
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Genome Databases showing AHR gene
(According to
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Specialized Databases showing AHR gene (According to PharmGKB ,
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About This Section Patent Information for AHR gene: Search GeneIP for patents involving AHR GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor AHR gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for AHR OriGene shRNA RFP for AHR OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for AHR OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for AHR OriGene Protein Over-expression Lysate for AHR Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for AHR OriGene 3'-UTR Clone for AHR OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AHR OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AHR Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AHR QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing AHR QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat AHR QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat AHR QIAGEN QuantiFast Probe-based Assays in human , mouse , rat AHR QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat AHR
Tocris compounds for AHR
AHR Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHR
ThermoFisher Antibody for AHR
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AHR
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