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AHR Gene

protein-coding GIFtS: 68

GC07P017304

aryl hydrocarbon receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
AH-receptor ^²
AhR ^³
BHLHE76 ^³
bHLHe76 ^¹, ², ³

Descriptions
Ah receptor ^³
Class E basic helix-loop-helix protein 76 ^³
aromatic hydrocarbon receptor ^²
aryl hydrocarbon receptor ^²

External Ids
HGNC: 348¹
Entrez Gene: 196²
UniProtKB: P35869³
Ensembl: ENSG00000106546⁷

Search outside databases for aliases for AHR gene

Previous GC identifers: GC07P016982 GC07P017082 GC07P017111

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AHR:

This gene encodes a ligand-activated transcription factor involved in the regulation of biological

responses to planar aromatic hydrocarbons. This receptor has been shown to regulate

xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of

aromatic hydrocarbons. [provided by RefSeq]

UniProtKB/Swiss-Prot: AHR_HUMAN, P35869

Function: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it

activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing

enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated

aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the

development and maturation of many tissues

Gene Wiki entry for AHR (Aryl_hydrocarbon_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AHR gene

Entrez Gene cytogenetic band: 7p15 Ensembl cytogenetic band: 7p21.1 HGNC cytogenetic band: 7p15

AHR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P017304: (about GC identifiers)

Start:	17,304,832 bp from pter
End:	17,352,299 bp from pter
Size:	47,468 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 17,391,703-17,439,184

RefSeq DNA sequence:

NC_000007.12 NT_007819.16 NT_079592.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AHR_HUMAN, P35869 (See protein sequence)

Recommended Name: Aryl hydrocarbon receptor precursor

Size: 848 amino acids; 96147 Da

Subunit: Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another

bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including

SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP

Subcellular location: Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and

interaction with a HSP90, it translocates to the nucleus

Secondary accessions: Q13728 Q13803 Q13804

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001612.1

ENSEMBL proteins:

ENSP00000385642 ENSP00000242057

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Aryl hydrocarbon Receptor )
	Human Recombinant Proteins from Abnova (AHR)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	10395741
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for AHR:

	Invitrogen Antibodies for AHR
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for AHR
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Aryl hydrocarbon Receptor ), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AHR)
	Novus Biologicals Antibodies for AHR

Assays for AHR:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P35869

ProtoNet protein and cluster: P35869

3 Blocks protein families:

IPB001092 Basic helix-loop-helix dimerization domain bHLH

IPB001610 PAC motif

IPB013655 PAS fold-3

UniProtKB/Swiss-Prot: AHR_HUMAN, P35869

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AHR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AHR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001621

Applied Biosystems Silencer® siRNAs for AHR

Sigma-Aldrich siRNA and siRNA Panels for AHR

Sigma-Aldrich shRNA for AHR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AHR
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001621
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001621
untagged cDNA clone in CMV expression vector: NM_001621

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001621

UniProtKB/Swiss-Prot: AHR_HUMAN, P35869

Function: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it

activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing

enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated

aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the

development and maturation of many tissues

Induction: Induced or repressed by TGF-beta and dioxin in a cell-type specific fashion. Repressed

by cAMP, retinoic acid, and TPA

Genatlas biochemistry entry for AHR:

aryl hydrocarbon receptor,unliganded,retained in cytoplasm in resting state in association with

HSP90,and with AIP (AH receptor associated protein 9),released after exposure to

xenobiotics,dimerizing with ARNT and translocated to the nucleus interacting with pRB1 to induce

G1 arrest

15 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Ahr):

	digestive/alimentary	endocrine/exocrine gland	growth/size	hematopoietic system
homeostasis/metabolism	immune system	lethality-postnatal	life span-post-weaning/aging	liver/biliary system
muscle	no phenotypic analysis	reproductive system	skin/coat/nails	tumorigenesis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IDA	11782478
GO:0004879	ligand-dependent nuclear receptor activity	IDA	10395741
GO:0008134	transcription factor binding	IPI	9079689
GO:0051879	Hsp90 protein binding	IDA	9079689

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for AHR (Your Favorite Gene powered by Ingenuity)

Xenobiotic Metabolism Signaling
Aryl Hydrocarbon Receptor Signaling

GeneDecks AHR for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for AHR

5/75 Interacting proteins for AHR (ENSP00000242057³ P35869¹) via UniProtKB, MINT, and/or STRING (see all 75 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AIP	O00170¹	STRING (score=.999) EBI-80780, EBI-704197
NCOA7	Q8NI08¹	STRING (score=.768) EBI-80780, EBI-80799
NCOR2	Q9Y618¹	STRING (score=.764) EBI-80780, EBI-80830
EBNA3 EBNA3 (xeno)	P12977¹	EBI-80780, EBI-993115
ARNT	ENSP00000315637³	STRING (score=.999)

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006366	transcription from RNA polymerase II promoter	IDA	10395741
GO:0006915	apoptosis	TAS	12213388
GO:0006950	response to stress	IDA	7961644
GO:0007049	cell cycle	TAS	12213388
GO:0007165	signal transduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for AHR

Browse Small Molecules at Sigma-Aldrich

Compounds for AHR available from Tocris Bioscience

Compound	Action	CAS number
ITE	Endogenous agonist for the transcription factor aryl hydrocarbon receptor	[448906-42-1]
Pifithrin-alpha hydrobromide	p53 inhibitor. Also aryl hydrocarbon receptor agonist	[63208-82-2]

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10/46 Novoseek chemical compound relationships for AHR gene (see all 46 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tcdd	97.64	1159	10777561 (7), 16613807 (6), 19056653 (6), 9415701 (5) (see all 99)
alpha-naphthoflavone	89.49	126	8385898 (4), 8390116 (3), 16569260 (2), 10630576 (2) (see all 52)
indolo(3,2-b)carbazole	86.38	14	7966413 (3), 15917307 (2), 18219281 (2), 18762178 (1) (see all 6)
hydrocarbons	85.01	113	12673023 (3), 8697610 (1), 9415701 (1), 18950284 (1) (see all 89)
3-methylcholanthrene	84.41	108	8163517 (4), 19270430 (4), 1654865 (4), 16257430 (4) (see all 40)
benzo(a)pyrene	83.55	157	18372000 (4), 10230769 (4), 17376491 (3), 17944540 (3) (see all 66)
mcdf	82.56	15	15087408 (2), 15026081 (2), 10822009 (1), 7821706 (1) (see all 7)
2-azido-3-(125i)iodo-7,8-dibromodibenzo-p-dioxin	80.44	2	15213304 (1), 1846218 (1)
dibenzofurans	79.62	22	12650590 (2), 8697610 (1), 18757099 (1), 8597135 (1) (see all 18)
tcdf	79.38	11	7840604 (1), 9501000 (1), 10387926 (1), 11032772 (1) (see all 7)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AHR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AHR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001621

Sigma-Aldrich siRNA and siRNA Panels for AHR

Sigma-Aldrich shRNA for AHR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001621

REFSEQ mRNAs for AHR gene:

NM_001621.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001621

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001621
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001621
                                 untagged cDNA clone in CMV expression vector: NM_001621

Additional cDNA sequence:

AK130815.1 AK307495.1 BC021696.1 BC069390.1 BC070080.1 D16354.1

9 DOTS entries:

DT.454488 DT.100654226 DT.97831966 DT.100654223 DT.92428380 DT.100654220 DT.100654222 DT.100654225

DT.91664671

24/208 AceView cDNA sequences (see all 208 ):

BX957133 CB216067 BX283596 N90226 BC070080 AI986448 AU185443 BM955721

CD516264 AI537555 BQ024331 AI361164 BU149806 AI082089 CB116426 AI306430

H77929 CA412565 BG178882 AI422236 AI801360 CN483485 D16354 BM724349

highest scoring ESTs for AHR:

AA757081 AI082089 AI358935 AL705131 AW169675 AW362856 AW600918 AW600935 BC069390 BF126553

Unigene Cluster for AHR:

Aryl hydrocarbon receptor

Hs.171189 [show with all ESTs]

Unigene Representative Sequence: NM_001621

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000401808 ENST00000242057

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AHR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AHR

¹ / ² / ³

3 probe-sets matching AHR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40516_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	L19872	0.80	0.88	0.84	1
202820_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_001621	0.60	1.00	0.82	1
202820_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks AHR for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CATAGATTTT

SOURCE GeneReport for Unigene cluster: Hs.171189
Expression variation in blood from EXPOLDB for AHR
UniProtKB/Swiss-Prot: AHR_HUMAN, P35869
Tissue specificity: Expressed in all tissues tested including blood, brain, heart, kidney, liver,
lung, pancreas and skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AHR gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AHR¹	--	aryl hydrocarbon receptor	88.14(n) 85.77(a)	475251 XM_532485.2 XP_532485.2
cow (Bos taurus)	AHR¹	--	aryl hydrocarbon receptor	84.82(n) 81.53(a)	280714 XM_612996.3 XP_612996.2
rat (Rattus norvegicus)	Ahr¹	--	aryl hydrocarbon receptor	78.12(n) 73.63(a)	25690 NM_013149.1 NP_037281.1
mouse (Mus musculus)	Ahr^{1, 5}	12 (18.00 cM)⁵	aryl-hydrocarbon receptor^{1, 5}	79.17(n)¹ 74.62(a)¹	11622¹ NM_013464.4¹ NP_038492.1¹ AF325111⁵ AF405560⁵ (see all 50)
chicken (Gallus gallus)	AHR¹	--	aryl hydrocarbon receptor	72.16(n) 67.96(a)	373907 NM_204118.1 NP_989449.1

About this table Species with no ortholog for AHR

ENSEMBL Gene Tree for AHR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AHR gene

AHRR²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/147 NCBI SNPs in AHR are shown (see all 147 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 69)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs1557737^1,2	A,C,F,H,O	17349632(-)	`GTTCTC/G/TTAACT`	1	--	ut3¹		18	MN EU EA CSAM NA NS	1694
	rs2066853^1,2	A,C,F,H	17345635(+)	`CATCAG/AACACA`	1	K/R	mis¹ ese³		24	EU MN CSAM EA WA NA NS	2715
	rs4986826^1,2	C,F,H	17345682(+)	`GTGAGG/ATTGAC`	1	I/V	mis¹ ese³		19	MN CSAM EA EU WA NS	1908
	rs17137616^1,2	C,F,H	17350390(+)	`TCATAT/CTTGAG`	1	--	ut3¹		18	NA MN CSAM EA EU WA NS	1626
	rs4987097^1,2	C,F	17349586(+)	`CTTTGA/CGTTTT`	1	--	ut3¹		8	MN CSAM EA NA	550
	rs35618592^1,2	C,F	17350735(+)	`TTACTG/TTCCTA`	1	--	ut3¹		11	MN CSAM EA NS	1064
	rs36103566^1,2	F	17350557(+)	`TGGGGC/GTTTAC`	1	--	ut3¹		5	MN CSAM EA	396
--	rs34755662^1,2	F	17351850(+)	`AAGCAA/GTATTR`	1	--	ut3¹		5	MN CSAM EA	408
	rs1803080^1,2	C	17351723(+)	`TCTTAC/TATAAA`	1	--	ut3¹		5	MN CSAM EA	408
	rs34029691^1,2	F	17351819(+)	`AGTTAT/CACAGT`	1	--	ut3¹		5	MN CSAM EA	408

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HapMap Linkage Disequilibrium images for AHR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600253

10/54 Novoseek disease relationships for AHR gene (see all 54 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ahh inducibility	61.77	1	7550366 (1)
breast cancer	58.84	94	11408954 (4), 11179685 (3), 11114727 (3), 10922479 (2) (see all 60)
mammary tumor	45.68	15	16972784 (2), 7966413 (1), 11179685 (1), 14973392 (1) (see all 11)
chemical carcinogenesis	43.57	2	15794642 (1), 12369945 (1)
adenocarcinoma lung	31.60	12	17200336 (5), 14644512 (1), 17127240 (1)
cancer	30.52	39	15028720 (2), 19015043 (2), 8395783 (2), 8921980 (2) (see all 22)
porphyria	24.70	9	18163543 (2), 11854449 (1), 9918132 (1), 8638948 (1)
micropenis	24.46	1	15758562 (1)
endometriosis	24.30	12	16084889 (4), 10724351 (4), 12200463 (1), 11393538 (1) (see all 5)
colon adenocarcinoma	24.25	3	16115717 (1), 8163517 (1), 1654865 (1)

About this table

Human Gene Mutation Database: AHR
Genetic Association Database: AHR
Human Genome Epidemiology Navigator: AHR (66 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/830 PubMed articles for AHR gene (see all 830 ):

Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer. (PubMed id 11698344)^{1, 3, 4, 6} Cauchi S.... Massaad-Massade L. (2001)
Analysis of the AhR, ARNT, and AhRR gene polymorphisms: genetic contribution to endometriosis susceptibility and severity. (PubMed id 16084889)^{1, 3, 6} Tsuchiya M.... Ikenoue T. (2005)
Interindividual difference in expression of human Ah receptor and related P450 genes. (PubMed id 7515333)^{1, 3, 4} Hayashi S.... Kawajiri K. (1994)
Genetic polymorphisms and transcriptional pattern analysis of CYP1A1, AhR, GSTM1, GSTP1 and GSTT1 genes in breast cancer. (PubMed id 11408954)^{1, 3, 6} Dialyna I.A....Spandidos D.A. (2001)
Polymorphism of alpha-estrogen receptor and aryl hydrocarbon receptor genes in dementia patients in Shanghai suburb. (PubMed id 12852830)^{1, 3, 6} Lin G.F....Shen J.H. (2003)
Human arylhydrocarbon receptor repressor (AHRR) gene: genomic structure and analysis of polymorphism in endometriosis. (PubMed id 11393538)^{1, 3, 6} Watanabe T....Inazawa J. (2001)
Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. (PubMed id 10739168)^{1, 3, 4} Smart J. and Daly A.K. (2000)
Association of micropenis with Pro185Ala polymorphism of the gene for aryl hydrocarbon receptor repressor involved in dioxin signaling. (PubMed id 15758562)^{1, 3, 6} Soneda S....Ogata T. (2005)
Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study. (PubMed id 16103451)^{1, 3, 6} Le Marchand L....Wilkens L.R. (2005)
Role of the aryl hydrocarbon receptor in cell cycle regulation. (PubMed id 12213388)^{1, 3, 4} Puga A.... Elferink C. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 196	HGNC: 348	AceView: AHR	Ensembl:ENSG00000106546	euGenes: HUgn196
ECgene: AHR	H-InvDB: AHR

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for AHR	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for AHR
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AHR:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AHR-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AHR		Antibodies for AHR
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AHR		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (AHR)
	Antibodies (AHR)
	Chimera RNAi (AHR)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Aryl hydrocarbon Receptor )
	Antibodies (Aryl hydrocarbon Receptor )

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	Drugs for AHR
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for AHR

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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AHR Gene at Home site.
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AHR Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for AHR

Summaries
for AHR

Genomic Location
for AHR

Proteins
for AHR

Protein Domains/
Families
for AHR

Gene Function
for AHR

Pathways & Interactions
for AHR

Drugs & Compounds
for AHR

Transcripts
for AHR

Expression
for AHR

Orthologs
for AHR

Paralogs
for AHR

SNPs/Variants
for AHR

Disorders & Mutations
for AHR

Medical News
for AHR

Publications
for AHR

Search for AHR

Genome Databases showing AHR

Other Databases showing AHR

Specialized Databases showing AHR

Licensable Technologies
for AHR

Services
for AHR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AHR Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor AHR

Summariesfor AHR

Genomic Locationfor AHR

Proteinsfor AHR

Protein Domains/Familiesfor AHR

Gene Functionfor AHR

Pathways & Interactionsfor AHR

Drugs & Compoundsfor AHR

Transcriptsfor AHR

Expression for AHR

Orthologsfor AHR

Paralogsfor AHR

SNPs/Variantsfor AHR

Disorders & Mutationsfor AHR

Medical Newsfor AHR

Publicationsfor AHR

Search for AHR

Genome Databases showing AHR

Other Databases showing AHR

Specialized Databases showing AHR

Licensable Technologiesfor AHR

Servicesfor AHR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AHR

Summaries
for AHR

Genomic Location
for AHR

Proteins
for AHR

Protein Domains/
Families
for AHR

Gene Function
for AHR

Pathways & Interactions
for AHR

Drugs & Compounds
for AHR

Transcripts
for AHR

Expression
for AHR

Orthologs
for AHR

Paralogs
for AHR

SNPs/Variants
for AHR

Disorders & Mutations
for AHR

Medical News
for AHR

Publications
for AHR

Licensable Technologies
for AHR

Services
for AHR