AHDC1 Gene
protein-coding GIFtS: 43
GCID: GC01M027860
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|
AT hook, DNA binding motif, containing 1
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Aliases
for AHDC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| AT Hook, DNA Binding Motif, Containing 11 2 | | DJ159A19.31 2 | | RP1-159A19.11 2 | | CL239452 | | A.T Hook DNA-Binding Motif-Containing Protein 12 | | AT-Hook DNA-Binding Motif-Containing Protein 12 |
Export aliases for AHDC1 gene to outside databasesPrevious GC identifers: GC01M027546 GC01M027733 GC01M026116 |
Summaries
for AHDC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for AHDC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AHDC1 gene promoter:
NRSF form 1 LUN-1 Nkx5-1 NRSF form 2 c-Ets-1 GATA-2 RORalpha1 AREB6 PPAR-gamma1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for AHDC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AHDC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36.13AHDC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M027860: view genomic region
(about GC identifiers)
Start:
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27,860,546 bp from pter |
End:
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27,930,942 bp from pter |
Size:
|
70,397 bases |
Orientation:
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minus strand |
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Proteins
for AHDC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AHDC1_HUMAN, Q5TGY3 (See
protein sequence)Recommended Name: AT-hook DNA-binding motif-containing protein 1 Size: 1603 amino acids; 168349 Da
Sequence caution: Sequence=AAB50205.1; Type=Frameshift; Positions=1331; Sequence=BAC86163.1; Type=Erroneous initiation;Sequence=CAI19618.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5TGY4 Q6PJK1 Q6ZUQ6 Q99769 Q9NUF5Explore the universe of human proteins at neXtProt for AHDC1: NX_Q5TGY3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5TGY3
AHDC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001025053.1
ENSEMBL proteins: ENSP00000247087 ENSP00000384021 ENSP00000363123
Human Recombinant Protein Products:
AHDC1 Antibody Products:
Assay Products for AHDC1: |
Protein
Domains /
Families
for AHDC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AHDC1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5TGY3ProtoNet protein and cluster: Q5TGY3 UniProtKB/Swiss-Prot: AHDC1_HUMAN, Q5TGY3Similarity: Contains 2 A.T hook DNA-binding domains |
Function
for AHDC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AHDC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AHDC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: AHDC1 (NM_001029882) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AHDC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHDC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHDC1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- |
AHDC1 for ontologies About GeneDecksing
|
Pathways & Interactions
for AHDC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AHDC1
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for AHDC1 (Q5TGY32, 3 ENSP000002470874) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for AHDC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AHDC1
Search CenterWatch for drugs/clinical trials and news about AHDC1
|
Transcripts
for AHDC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AHDC1 gene: NM_001029882.2 Unigene Cluster for AHDC1: AT hook, DNA binding motif, containing 1 Hs.469280 [show with all ESTs]Unigene Representative Sequence: NM_0010298828 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000247087 ENST00000482400(uc001boh.1) ENST00000407475 ENST00000487743
ENST00000490295 ENST00000479753 ENST00000480033 ENST00000374011(uc009vsy.3 uc009vsz.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AHDC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AHDC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AHDC1 (NM_001029882) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AHDC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHDC1 |
Additional cDNA sequence: AK125431.1 BC002677.2 BC014394.1 BC064935.1 U79259.1 6 DOTS entries: DT.442557 DT.99947564 DT.102823003 DT.210044 DT.100746075 DT.40195032 24/121 AceView cDNA sequences (see all 121): AW628710 BF434367 BU949869 CA393712 AW069028 BX114728 AK125431 AI521992 AA688390 AI017655 AI971666 AA856845 AW166358 BF933000 BC014394 AA927142 BC064935 BG055913 CD675468 AA514886 BC002677 AI933793 AI754203 T60121
GeneLoc Exon Structure
|
Expression
for AHDC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AHDC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGGGGGGA
About this image
See AHDC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AHDC1
SOURCE GeneReport for Unigene cluster: Hs.469280
SABiosciences Custom PCR Arrays for AHDC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AHDC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AHDC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AHDC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AHDC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHDC1 |
Orthologs
for AHDC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for AHDC1 gene from 5/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ahdc11 , 5 |
AT hook, DNA binding motif, containing 11, 5 |
88.18(n)1
95.36(a)1 |
|
4 (66.18 cM)5
2307931 NM_146155.31 NP_666267.31
1330112605 |
chicken
(Gallus gallus) |
Aves |
LOC1008590231 |
AT-hook DNA-binding motif-containing protein 1-like less |
75.75(n)
74.29(a) |
|
100859023 XM_003643517.1 XP_003643565.1 |
lizard
(Anolis carolinensis) |
Reptilia |
AHDC16 |
-- |
64(a) |
1 ↔ 1 |
GL343464.1(439490-443980) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.146962 |
Xenopus laevis transcribed sequence with weak similarity to protein refNP_056514.1 (H.sapiens) hypothetical protein DJ159A19.3 [Homo sapiens] less |
78.13(n) |
|
BJ057778.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ahdc16 |
AT hook, DNA binding motif, containing 1 |
35(a) |
1 ↔ 1 |
19(45083353-45144251) |
ENSEMBL Gene Tree for AHDC1 (if available)
TreeFam Gene Tree for AHDC1 (if available) |
Paralogs
for AHDC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for AHDC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AHDC1 (27860546 - 27930942 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for AHDC1
1 CNV: 53092
2 Indels: 63345 59924 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AHDC1 |
|
Disorders
/ Diseases
for AHDC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AHDC1 for disorders About GeneDecksing
1  disease for AHDC1: About MalaCardsataxia
Export disorders for AHDC1 gene to outside databases
|
Publications
for AHDC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AHDC1 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with AHDC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 2, 3 Yu W.... Gibbs R.A. (1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
- Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)
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External Searches for AHDC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AHDC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AHDC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AHDC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AHDC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for AHDC1 gene:
Search GeneIP for patents involving AHDC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AHDC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AHDC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AHDC1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AHDC1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AHDC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AHDC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for AHDC1 | | OriGene Custom Protein Services for AHDC1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AHDC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AHDC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AHDC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AHDC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AHDC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AHDC1 |
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| | | | Search Tocris compounds for AHDC1 |
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 | | | AHDC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHDC1 |
|  |  |  | | | | Search ThermoFisher Antibodies for AHDC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHDC1 |
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