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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AHCYL2 Gene

protein-coding GIFtS: 55
GCID: GC07P128865

adenosylhomocysteinase-like 2

(Previous name: S-adenosylhomocysteine hydrolase-like 2 )

Explore 6 diseases affiliated with
AHCYL2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adenosylhomocysteinase-Like 2¹ ²		ADOHCYASE3²
S-Adenosylhomocysteine Hydrolase-Like 2¹ ²		Putative Adenosylhomocysteinase 3²
KIAA0828¹ ³		AdoHcyase 3³
S-Adenosyl-L-Homocysteine Hydrolase 3² ³		S-Adenosylhomocysteine Hydrolase-Like Protein 2³
EC 3.3.1.1³ ⁸

External Ids:	HGNC: 22204¹	Entrez Gene: 23382²	Ensembl: ENSG00000158467⁷	UniProtKB: Q96HN2³

Export aliases for AHCYL2 gene to outside databases

Previous GC identifers: GC07P128653 GC07P123225

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AHCYL2:

The protein encoded by this gene acts as a homotetramer and may be involved in the conversion of

S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding different isoforms

have been found for this gene. (provided by RefSeq, Jun 2011)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AHCYL2 gene promoter:
RP58 RelA AP-2gamma AREB6 SRY Cart-1 AP-2beta AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): AHCYL2 promoter sequence

Search SABiosciences Chromatin IP Primers for AHCYL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AHCYL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32.1 Ensembl cytogenetic band: 7q32.1 HGNC cytogenetic band: 7q32.1

AHCYL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AHCYL2 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P128865: view genomic region (about GC identifiers)

Start:	128,864,855 bp from pter	End:	129,070,052 bp from pter
Size:	205,198 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 128,248,814-128,454,023

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SAHH3_HUMAN, Q96HN2 (See protein sequence)

Recommended Name: Putative adenosylhomocysteinase 3

Size: 611 amino acids; 66721 Da

Cofactor: Binds 1 NAD per subunit

Subunit: Homotetramer (Probable)

Sequence caution: Sequence=BAA74851.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

1 PDB 3D structure from and Proteopedia for AHCYL2:

3GVP (3D)

Secondary accessions: B4DIZ5 D9N155 O94917

Alternative splicing: 4 isoforms: Q96HN2-1 Q96HN2-2 Q96HN2-3 Q96HN2-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AHCYL2: NX_Q96HN2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96HN2

4/21 DME Specific Peptides for AHCYL2 (Q96HN2) (see all 21)

EIDPICA

QAKYLGL

QACMDGF

ACNIYST

AHCYL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001124192.1 NP_001124194.2 NP_001124195.1 NP_056143.1

ENSEMBL proteins:

ENSP00000315931 ENSP00000413639 ENSP00000419717 ENSP00000420459 ENSP00000420801

ENSP00000419608 ENSP00000419346 ENSP00000431787 ENSP00000405267

Human Recombinant Protein Products:

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	Novus Biologicals AHCYL2 Protein
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for AHCYL2

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	Uscn ELISAs and CLIAs for AHCYL2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AHCYL2 for domains About GeneDecksing

4 InterPro domains/families:

IPR020082 S-Ado-L-homoCys_hydrolase_CS

IPR000043 Adenosylhomocysteinase

IPR015878 Ado_hCys_hydrolase_NAD-bd

IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry Q96HN2

ProtoNet protein and cluster: Q96HN2

1 Blocks protein family: IPB000043 S-adenosyl-L-homocysteine hydrolase

UniProtKB/Swiss-Prot: SAHH3_HUMAN, Q96HN2

Similarity: Belongs to the adenosylhomocysteinase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SAHH3_HUMAN, Q96HN2

Catalytic activity: S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine

Enzyme Number (IUBMB): EC 3.3.1.1¹ ²

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AHCYL2
		8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate AHCYL2 (see all 59):
		hsa-miR-330-5p hsa-miR-15a hsa-miR-3653 hsa-miR-650 hsa-miR-449a hsa-miR-374c hsa-miR-424 hsa-miR-3658

		SwitchGear 3'UTR luciferase reporter plasmid: AHCYL2 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHCYL2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004013	adenosylhomocysteinase activity	IEA	--

AHCYL2 for ontologies About GeneDecksing

Animal Models:
1 MGI phenotypic allele

for Ahcyl2 (no phenotypes)

AHCYL2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Methionine metabolism

Methionine metabolism	1.00	superpathway of methionine degradation	0.38
Methionine metabolism	1.00	methionine degradation I (to homocysteine)	0.31
cysteine biosynthesis III (mammalia)	0.44

One Carbon Metabolism

One Carbon Metabolism

1.00

Metabolism

Metabolic pathways

0.38

Sulfur amino acid metabolism

Cysteine and methionine metabolism

0.36

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for AHCYL2

Methionine metabolism

1 GeneGo (Thomson Reuters) Pathway for AHCYL2

Methionine metabolism

4 BioSystems Pathways for AHCYL2

	One Carbon Metabolism
	cysteine biosynthesis III (mammalia)
	methionine degradation I (to homocysteine)
	superpathway of methionine degradation

2 Kegg Pathways (Kegg details for AHCYL2):

	Cysteine and methionine metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: SAHH3_HUMAN, Q96HN2

Pathway: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1

AHCYL2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for AHCYL2

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/20 Interacting proteins for AHCYL2 (Q96HN2³ ENSP00000315931⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAP1	Q92560³, ENSP00000417132⁴	I2D: score=2 STRING: ENSP00000417132
SLX4	Q8IY92³, ENSP00000294008⁴	I2D: score=1 STRING: ENSP00000294008
WDR48	Q8TAF3³, ENSP00000307491⁴	I2D: score=2 STRING: ENSP00000307491
MAP3K5	Q99683³	I2D: score=2
JOSD2	Q8TAC2³	I2D: score=1

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006730	one-carbon metabolic process	IEA	--

AHCYL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AHCYL2

8 HMDB Compounds for AHCYL2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine	1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)	58-61-7	--
Homocysteine	(+-)-homocysteine (see all 22)	454-29-5	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
S-Adenosylhomocysteine	(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)	979-92-0	--
S-Adenosylmethionine	(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)	29908-03-0	--
Se-Adenosylselenohomocysteine		--	--
Selenohomocysteine	Se-selenocysteine (see all 3)	29412-93-9	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

Search CenterWatch for drugs/clinical trials and news about AHCYL2 / SAHH3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AHCYL2 gene (4 alternative transcripts):

NM_001130720.2 NM_001130722.2 NM_001130723.2 NM_015328.3

Unigene Cluster for AHCYL2:

Adenosylhomocysteinase-like 2

Hs.600789 [show with all ESTs]

Unigene Representative Sequence: NM_001130723

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000325006(uc003vot.3 uc011kov.2) ENST00000446544(uc011kox.2)

ENST00000461161 ENST00000460109 ENST00000474594 ENST00000490911 ENST00000466993

ENST00000466924 ENST00000472554 ENST00000491079 ENST00000492628 ENST00000477028

ENST00000531335 ENST00000446212(uc003vov.3)

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		8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate AHCYL2 (see all 59):
		hsa-miR-330-5p hsa-miR-15a hsa-miR-3653 hsa-miR-650 hsa-miR-449a hsa-miR-374c hsa-miR-424 hsa-miR-3658

		SwitchGear 3'UTR luciferase reporter plasmid: AHCYL2 3' UTR sequence

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Additional cDNA sequence:

AB020635.1 AK025372.1 AK172759.1 AK295851.1 AK316073.1 BC008349.1 BC024325.1

15 DOTS entries:

DT.95271966 DT.100750040 DT.70105202 DT.95271965 DT.100747382 DT.40283412 DT.92442183 DT.102834191

DT.75114560 DT.75194541 DT.95113775 DT.100691386 DT.100713182 DT.40122588 DT.92442176

24/158 AceView cDNA sequences (see all 158):

BE765809 CR595025 AB020635 BC024325 BE504378 BE765884 BE765910 CA394559

CB988319 BM708568 AI961915 AA745811 AA557563 AI167403 BC008349 BE766371

BE765861 CA396888 BM475929 AI332704 BE766375 AI473714 BM682065 BM684363

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AHCYL2 (see all 7) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b	^	19	^
SP1:					-		-		-						-																																-
SP2:									-		-				-																																-
SP3:											-				-
SP4:
SP5:

ExUns:	20	^	21a	·	21b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for AHCYL2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AHCYL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCACATACT

About this image

AHCYL2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See AHCYL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AHCYL2

SOURCE GeneReport for Unigene cluster: Hs.600789

SABiosciences Custom PCR Arrays for AHCYL2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AHCYL2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AHCYL2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHCYL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for AHCYL2 gene from 8/32 species (see all 32) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	AHCYL2¹	adenosylhomocysteinase-like 2	83.74(n) 99.8(a)		416675 XM_414971.3 XP_414971.3
lizard (Anolis carolinensis)	Reptilia	AHCYL2⁶ AHCY⁶	--	91(a) 50(a)	1 ↔ 1 possible ortholog	AAWZ02037050(988-15951) 4(138042257-138060141)
African clawed frog (Xenopus laevis)	Amphibia	BJ079574.1²	--	82.79(n)		BJ079574.1
zebrafish (Danio rerio)	Actinopterygii	BC059517.1²	--	76.69(n)		394240 BC059517.1
fruit fly (Drosophila melanogaster)	Insecta	CG9977¹	CG9977	71.29(n) 80.38(a)		38342 NM_139489.1 NP_647746.1
worm (Caenorhabditis elegans)	Secernentea	ahcy-1⁶	Adenosylhomocysteinase	51(a)	possible ortholog	I(6836389-6838141)
thale cress (Arabidopsis thaliana)	eudicotyledons	SAHH2⁶ HOG1⁶	adenosylhomocysteinase 1	45(a) 45(a)	possible ortholog possible ortholog	3(8587664-8589713) 4(8054861-8057181)
rice (Oryza sativa)	Liliopsida	--	erythronate-4-phosphate dehydrogenase, putative, e...	45(a)	possible ortholog	11(14956262-14959287)

ENSEMBL Gene Tree for AHCYL2 (if available)
TreeFam Gene Tree for AHCYL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for AHCYL2 gene

AHCYL1² AHCY²

2 SIMAP similar genes for AHCYL2 using alignment to 6 protein entries: SAHH3_HUMAN (see all proteins):

AHCYL1 AHCY

AHCYL2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs60474507^1,2	C,	--	128247498(+)	`GACGGC/TATCTC`	2	--	us2k¹		1		WA	2
rs13228930^1,2	C	--	128249025(+)	`AGACCA/CTGAGG`	4	H P	mis¹ ese³		0	--	--	--	--
rs113686059^1,2	C,	--	128249728(+)	`GATGAC/TTTTCT`	2	--	int¹		2		CSA WA	120
rs73230596^1,2	C,	--	128249803(+)	`GCGATA/GTTCTC`	2	--	int¹		0	--	--	--	--
rs61039599^1,2	C,	--	128249815(+)	`CTTCCC/TTGAAT`	2	--	int¹		2		WA	120
rs77829177^1,2	F,	--	128250072(+)	`ATACCA/GAGAAG`	2	--	int¹		1		NA	120
rs77191977^1,2		--	128250258(+)	`ATTTCG/TTAGAC`	2	--	int¹		1		NA	120
rs113767559^1,2		--	128250412(+)	`ATAACG/TTTTTG`	2	--	int¹		1		CSA	2
rs55734328^1,2	C,	--	128250550(+)	`GTAGTG/ATGAAA`	2	--	int¹		1		WA	2
rs34643315^1,2	C,	--	128250916(+)	`ATCAGT/CTTCCT`	2	--	int¹		3		NA	124

HapMap Linkage Disequilibrium report for AHCYL2 (128864855 - 129070052 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for AHCYL2
2 CNVs: 100118 52085

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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AHCYL2 for disorders About GeneDecksing

6 diseases for AHCYL2: About MalaCards

homocysteine lung carcinoma tuberculosis carcinoma

malaria mycobacterium tuberculosis

Export disorders for AHCYL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for AHCYL2 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with AHCYL2)

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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{1, 2} Nagase T....Ohara O. (1998)
A genome-wide association study of inflammatory biomar ker changes in response to fenofibrate treatment in the Genetics of Lipid Loweri ng Drug and Diet Network. (PubMed id 22228203)¹ Aslibekyan S....Arnett D.K. (2012)
Genome-wide association study indicates variants assoc iated with insulin signaling and inflammation mediate lipoprotein responses to f enofibrate. (PubMed id 22890011)¹ Frazier-Wood A.C....Arnett D.K. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
Genome-wide association analyses identifies a suscept ibility locus for tuberculosis on chromosome 18q11.2. (PubMed id 20694014)¹ Thye T....Hill A.V. (2010)
Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)¹ Sowa M.E....Harper J.W. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23382	HGNC: 22204	AceView: KIAA0828	Ensembl:ENSG00000158467	euGenes: HUgn23382
ECgene: AHCYL2	Kegg: 23382	H-InvDB: AHCYL2

(According to HUGE)
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HUGE: KIAA0828

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for AHCYL2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for AHCYL2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for AHCYL2 gene:
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GeneCards and IP:
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adenosylhomocysteinase-like 2

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AHCYL2 Gene

adenosylhomocysteinase-like 2

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