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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AHCYL2 Gene

protein-coding   GIFtS: 56
GCID: GC07P128865

Adenosylhomocysteinase-Like 2

(Previous name: S-adenosylhomocysteine hydrolase-like 2)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adenosylhomocysteinase-Like 21 2     Putative Adenosylhomocysteinase 32
S-Adenosylhomocysteine Hydrolase-Like 21 2     KIAA08283
S-Adenosyl-L-Homocysteine Hydrolase 32 3     AdoHcyase 33
EC 3.3.1.13 8     S-Adenosylhomocysteine Hydrolase-Like Protein 23
ADOHCYASE32     

External Ids:    HGNC: 222041   Entrez Gene: 233822   Ensembl: ENSG000001584677   UniProtKB: Q96HN23   

Export aliases for AHCYL2 gene to outside databases

Previous GC identifers: GC07P128653 GC07P123225


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AHCYL2 Gene:
The protein encoded by this gene acts as a homotetramer and may be involved in the conversion of
S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jun 2011)

GeneCards Summary for AHCYL2 Gene: 
AHCYL2 (adenosylhomocysteinase-like 2) is a protein-coding gene. Diseases associated with AHCYL2 include tuberculosis, and among its related super-pathways are Sulfur amino acid metabolism and cysteine biosynthesis III (mammalia). GO annotations related to this gene include adenosylhomocysteinase activity and nucleotide binding. An important paralog of this gene is AHCYL1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AHCYL2 gene promoter:
         RP58   RelA   AP-2gamma   AREB6   SRY   Cart-1   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): AHCYL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for AHCYL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AHCYL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32.1   Ensembl cytogenetic band:  7q32.1   HGNC cytogenetic band: 7q32.1

AHCYL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AHCYL2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P128865:  view genomic region     (about GC identifiers)

Start:
128,864,855 bp from pter      End:
129,070,052 bp from pter
Size:
205,198 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 128,248,814-128,454,023     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SAHH3_HUMAN, Q96HN2 (See protein sequence)
Recommended Name: Putative adenosylhomocysteinase 3  
Size: 611 amino acids; 66721 Da
Cofactor: Binds 1 NAD per subunit
Subunit: Homotetramer (Probable)
Sequence caution: Sequence=BAA74851.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for AHCYL2:
3GVP (3D)    
Secondary accessions: B4DIZ5 D9N155 O94917
Alternative splicing: 4 isoforms:  Q96HN2-1   Q96HN2-2   Q96HN2-3   Q96HN2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AHCYL2: NX_Q96HN2

Explore proteomics data for AHCYL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96HN2

  • 4/21 DME Specific Peptides for AHCYL2 (Q96HN2) (see all 21)
     EIDPICA  QAKYLGL  QACMDGF  ACNIYST 

    AHCYL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AHCYL2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001124192.1  NP_001124194.2  NP_001124195.1  NP_056143.1  

    ENSEMBL proteins: 
     ENSP00000315931   ENSP00000413639   ENSP00000419717   ENSP00000420459   ENSP00000420801  
     ENSP00000419608   ENSP00000419346   ENSP00000431787   ENSP00000405267  

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    Cloud-Clone Corp. CLIAs for AHCYL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR020082 S-Ado-L-homoCys_hydrolase_CS
     IPR000043 Adenosylhomocysteinase
     IPR015878 Ado_hCys_hydrolase_NAD-bd
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q96HN2

    ProtoNet protein and cluster: Q96HN2

    1 Blocks protein domain: IPB000043 S-adenosyl-L-homocysteine hydrolase

    UniProtKB/Swiss-Prot: SAHH3_HUMAN, Q96HN2
    Similarity: Belongs to the adenosylhomocysteinase family


    AHCYL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAHH3_HUMAN, Q96HN2
    Catalytic activity: S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine

         Enzyme Number (IUBMB): EC 3.3.1.11 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004013adenosylhomocysteinase activity IEA--
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----
    GO:0048037cofactor binding ----
         
    AHCYL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Ahcyl2 (no phenotypes)

    AHCYL2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AHCYL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AHCYL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AHCYL2 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidAHCYL2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AHCYL2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cysteine and methionine metabolism
    Cysteine and methionine metabolism0.37
    Methionine metabolism0.32
    2methionine degradation I (to homocysteine)
    methionine degradation I (to homocysteine)0.83
    cysteine biosynthesis III (mammalia)0.83
    3One Carbon Metabolism
    One Carbon Metabolism0.53
    4Metabolism
    Metabolic pathways0.40
    52-oxobutanoate degradation I
    superpathway of methionine degradation0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for AHCYL2
        Methionine metabolism


    1 GeneGo (Thomson Reuters) Pathway for AHCYL2
        Methionine metabolism

    4 BioSystems Pathways for AHCYL2
        One Carbon Metabolism
    methionine degradation I (to homocysteine)
    superpathway of methionine degradation
    cysteine biosynthesis III (mammalia)


    2         Kegg Pathways  (Kegg details for AHCYL2):
        Cysteine and methionine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: SAHH3_HUMAN, Q96HN2
    Pathway: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step
    1/1


    AHCYL2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AHCYL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/20 Interacting proteins for AHCYL2 (Q96HN23 ENSP000003159314) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAP1Q925603, ENSP000004171324I2D: score=2 STRING: ENSP00000417132
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    WDR48Q8TAF33, ENSP000003074914I2D: score=2 STRING: ENSP00000307491
    MAP3K5Q996833I2D: score=2 
    JOSD2Q8TAC23I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006730one-carbon metabolic process IEA--
    GO:0055114oxidation-reduction process ----

    AHCYL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AHCYL2 (SAHH3)

    8 HMDB Compounds for AHCYL2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)58-61-7--
    Homocysteine(+-)-homocysteine (see all 22)454-29-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    Se-Adenosylselenohomocysteine ----
    SelenohomocysteineSe-selenocysteine (see all 3)29412-93-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about AHCYL2 / SAHH3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AHCYL2 gene (4 alternative transcripts): 
    NM_001130720.2  NM_001130722.2  NM_001130723.2  NM_015328.3  

    Unigene Cluster for AHCYL2:

    Adenosylhomocysteinase-like 2
    Hs.600789  [show with all ESTs]
    Unigene Representative Sequence: NM_001130723
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000325006(uc003vot.3 uc011kov.2) ENST00000446544(uc011kox.2)
    ENST00000461161 ENST00000460109 ENST00000474594 ENST00000490911 ENST00000466993
    ENST00000466924 ENST00000472554 ENST00000491079 ENST00000492628 ENST00000477028
    ENST00000531335 ENST00000446212(uc003vov.3)
    miRNA
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    hsa-miR-330-5p hsa-miR-15a hsa-miR-3653 hsa-miR-650 hsa-miR-449a hsa-miR-374c hsa-miR-424 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidAHCYL2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB020635.1 AK025372.1 AK172759.1 AK295851.1 AK316073.1 BC008349.1 BC024325.1 

    15 DOTS entries:

    DT.95271966  DT.100750040  DT.70105202  DT.100747382  DT.95271965  DT.40283412  DT.92442183  DT.102834191 
    DT.75114560  DT.75194541  DT.95113775  DT.100691386  DT.100713182  DT.40122588  DT.92442176 

    24/158 AceView cDNA sequences (see all 158):

    N26728 BE048933 BM682065 AA745811 AA433837 BM684363 BM708568 BE765861 
    H99883 BE765733 R37070 BE765809 BC024325 BE765910 AA557563 AB020635 
    BE504378 CA396888 BX104634 AI140407 AI167403 BE765884 BE766375 CR595025 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AHCYL2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
    SP1:              -     -     -                 -                                                                                               -               
    SP2:                          -     -           -                                                                                               -               
    SP3:                                -           -                                                                                                               
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21a · 21b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for AHCYL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AHCYL2 expression in normal human tissues (normalized intensities)      AHCYL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCACATACT
    AHCYL2 Expression
    About this image


    AHCYL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Thalamus
             ganglion/cranial   
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             visceral organ/oral region/upper jaw   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Colon (Gastrointestinal Tract)
             colonic mucosal (ibs)   
     
     Neural Tube (Nervous System)
             Diencephalon

    See AHCYL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AHCYL2

    SOURCE GeneReport for Unigene cluster: Hs.600789
        SABiosciences Custom PCR Arrays for AHCYL2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHCYL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for AHCYL2 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ahcyl21 , 5 S-adenosylhomocysteine hydrolase-like 21, 5 92.36(n)1
    99.18(a)1
      6 (12.36 cM)5
    743401  NM_021414.61  NP_067389.51 
     297680115 
    chicken
    (Gallus gallus)
    Aves AHCYL21 adenosylhomocysteinase-like 2 83.74(n)
    99.8(a)
      416675  XM_414971.3  XP_414971.3 
    lizard
    (Anolis carolinensis)
    Reptilia AHCYL26
    --
    Uncharacterized protein
    97(a)
    87(a)
    1 ↔ 1
    possible ortholog
    GL343653.1(159732-191632)
    AAWZ02037050(150-16592)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ079574.12   -- 82.79(n)    BJ079574.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059517.12   -- 76.69(n)   394240  BC059517.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG99771 CG9977 71.29(n)
    80.38(a)
      38342  NM_139489.1  NP_647746.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SAH16
    S-adenosyl-L-homocysteine hydrolase, catabolizes S...
    48(a)
    1 → many
    V(235770-237119)


    ENSEMBL Gene Tree for AHCYL2 (if available)
    TreeFam Gene Tree for AHCYL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AHCYL2 gene
    AHCYL12  AHCY2  
    2 SIMAP similar genes for AHCYL2 using alignment to 6 protein entries:     SAHH3_HUMAN (see all proteins):
    AHCYL1    AHCY

    AHCYL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3678 SNPs in AHCYL2 are shown (see all 3678)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs47315651,2
    C,F--128249089(+) GCCGCC/TGCTCT 4 A syn1 ese33Minor allele frequency- T:0.25NA 124
    rs339899091,2
    C--128250727(+) TGTAT-/ACTT  
            
    CGTTA
    2 -- int10--------
    rs580886471,2
    C--128251281(+) AAAAA-/A/AAAA
            
    GAGCC
    2 -- int11NA 2
    rs586530861,2
    C--128280352(+) CCCAC-/A/    
       AC
    /CC
    CCCCC
    2 -- int11NA 2
    rs27180831,2
    C,F,A,H--128280372(+) AATCTT/ATCTTG 2 -- int18Minor allele frequency- A:0.38NS EA NA WA 654
    rs106619401,2
    C--128291044(+) TGTGT-/ATGTGTGT/ATGT
    GTGTGT
    /GTGT/TGTG
    GTGTG
    2 -- int11NA 2
    rs353510671,2
    C--128300225(+) GAATA-/AAAAAA 2 -- int10--------
    rs357530231,2
    C--128301072(+) CTCTC-/G/TTTTTT 2 -- int10--------
    rs352533411,2
    C--128304762(+) CCTGGG/-TTCAA 2 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs2008556841,2
    C--128438231(+) TGTTTC/TTTTTT 4 -- int10--------

    HapMap Linkage Disequilibrium report for AHCYL2 (128864855 - 129070052 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for AHCYL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2735148CNV Deletion23290073
    esv268220CNV Insertion20981092
    esv273568CNV Insertion20981092
    esv2559463CNV Insertion19546169
    nsv525482CNV Loss19592680
    nsv516498CNV Gain19592680
    nsv831128CNV Gain17160897
    nsv831127CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for AHCYL2:    About MalaCards
    tuberculosis    


    AHCYL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AHCYL2

    Export disorders for AHCYL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AHCYL2 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with AHCYL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association study of inflammatory biomar ker changes in response to fenofibrate treatment in the Genetics of Lipid Loweri ng Drug and Diet Network. (PubMed id 22228203)1, 4 Aslibekyan S....Arnett D.K. (2012)
    2. Genome-wide association analyses identifies a suscept ibility locus for tuberculosis on chromosome 18q11.2. (PubMed id 20694014)1, 4 Thye T....Hill A.V. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
    5. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    6. Genome-wide association study indicates variants assoc iated with insulin signaling and inflammation mediate lipoprotein responses to f enofibrate. (PubMed id 22890011)1 Frazier-Wood A.C....Arnett D.K. (2012)
    7. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23382 HGNC: 22204 AceView: KIAA0828 Ensembl:ENSG00000158467 euGenes: HUgn23382
    ECgene: AHCYL2 Kegg: 23382 H-InvDB: AHCYL2

    (According to HUGE)
    About This Section
    HUGE: KIAA0828

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AHCYL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AHCYL2 gene:
    Search GeneIP for patents involving AHCYL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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