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Aliases for AHCYL2 Gene

Aliases for AHCYL2 Gene

  • Adenosylhomocysteinase-Like 2 2 3
  • IP(3)Rs Binding Protein Released With IP(3) 2 3 4
  • S-Adenosylhomocysteine Hydrolase-Like 2 2 3
  • S-Adenosyl-L-Homocysteine Hydrolase 3 3 4
  • EC 4 63
  • IRBIT2 3 4
  • S-Adenosylhomocysteine Hydrolase-Like Protein 2 4
  • Putative Adenosylhomocysteinase 3 3
  • AdoHcyase 3 4
  • KIAA0828 4

External Ids for AHCYL2 Gene

Previous GeneCards Identifiers for AHCYL2 Gene

  • GC07P128653
  • GC07P128865
  • GC07P123225

Summaries for AHCYL2 Gene

Entrez Gene Summary for AHCYL2 Gene

  • The protein encoded by this gene acts as a homotetramer and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for AHCYL2 Gene

AHCYL2 (Adenosylhomocysteinase-Like 2) is a Protein Coding gene. Among its related pathways are Metabolism and One carbon pool by folate. GO annotations related to this gene include adenosylhomocysteinase activity. An important paralog of this gene is AHCYL1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AHCYL2 Gene

Genomics for AHCYL2 Gene

Regulatory Elements for AHCYL2 Gene

Genomic Location for AHCYL2 Gene

129,225,014 bp from pter
129,430,211 bp from pter
205,198 bases
Plus strand

Genomic View for AHCYL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AHCYL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AHCYL2 Gene

Proteins for AHCYL2 Gene

  • Protein details for AHCYL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative adenosylhomocysteinase 3
    Protein Accession:
    Secondary Accessions:
    • B4DIZ5
    • D9N155
    • O94917

    Protein attributes for AHCYL2 Gene

    611 amino acids
    Molecular mass:
    66721 Da
    Name=NAD(+); Xref=ChEBI:CHEBI:57540; Note=Binds 1 NAD(+) per subunit.;
    Quaternary structure:
    • Homotetramer.
    • Sequence=BAA74851.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AHCYL2 Gene

    Alternative splice isoforms for AHCYL2 Gene


neXtProt entry for AHCYL2 Gene

Proteomics data for AHCYL2 Gene at MOPED

Post-translational modifications for AHCYL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains for AHCYL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the adenosylhomocysteinase family.
  • Belongs to the adenosylhomocysteinase family.
genes like me logo Genes that share domains with AHCYL2: view

No data available for Gene Families for AHCYL2 Gene

Function for AHCYL2 Gene

Molecular function for AHCYL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine

Enzyme Numbers (IUBMB) for AHCYL2 Gene

Gene Ontology (GO) - Molecular Function for AHCYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004013 NOT adenosylhomocysteinase activity IBA --
GO:0051287 NAD binding --
genes like me logo Genes that share ontologies with AHCYL2: view

Animal Model Products

CRISPR Products

miRNA for AHCYL2 Gene

miRTarBase miRNAs that target AHCYL2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AHCYL2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for AHCYL2 Gene

Localization for AHCYL2 Gene

Subcellular locations from

Jensen Localization Image for AHCYL2 Gene COMPARTMENTS Subcellular localization image for AHCYL2 gene
Compartment Confidence
cytosol 3
chloroplast 2
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AHCYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with AHCYL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for AHCYL2 Gene

Pathways for AHCYL2 Gene

genes like me logo Genes that share pathways with AHCYL2: view

Pathways by source for AHCYL2 Gene

1 GeneGo (Thomson Reuters) pathway for AHCYL2 Gene

UniProtKB/Swiss-Prot Q96HN2-SAHH3_HUMAN

  • Pathway: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1

Gene Ontology (GO) - Biological Process for AHCYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006730 one-carbon metabolic process IEA --
GO:0033353 S-adenosylmethionine cycle IBA --
GO:0055114 oxidation-reduction process --
genes like me logo Genes that share ontologies with AHCYL2: view

Drugs for AHCYL2 Gene

(8) HMDB Compounds for AHCYL2 Gene

Compound Synonyms Cas Number PubMed IDs
  • 1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
  • (+-)-homocysteine
  • 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate inner salt
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
genes like me logo Genes that share compounds with AHCYL2: view

Transcripts for AHCYL2 Gene

Unigene Clusters for AHCYL2 Gene

Adenosylhomocysteinase-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AHCYL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AHCYL2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1: - - - - -
SP2: - - - -
SP3: - -
SP6: - - -
SP7: - - - - - -

ExUns: 20 ^ 21a · 21b

Relevant External Links for AHCYL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AHCYL2 Gene

mRNA expression in normal human tissues for AHCYL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AHCYL2 Gene

This gene is overexpressed in Colon - Transverse (4.9).

Protein differential expression in normal tissues for AHCYL2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.4), Brain (10.7), and Frontal cortex (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AHCYL2 Gene

SOURCE GeneReport for Unigene cluster for AHCYL2 Gene Hs.600789

genes like me logo Genes that share expressions with AHCYL2: view

Expression partners for AHCYL2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AHCYL2 Gene

Orthologs for AHCYL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AHCYL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AHCYL2 35
  • 93.34 (n)
  • 99.18 (a)
  • 99 (a)
(Canis familiaris)
Mammalia AHCYL2 35
  • 95.08 (n)
  • 99.51 (a)
  • 94 (a)
(Mus musculus)
Mammalia Ahcyl2 35
  • 91.38 (n)
  • 97.87 (a)
Ahcyl2 16
Ahcyl2 36
  • 99 (a)
(Pan troglodytes)
Mammalia AHCYL2 35
  • 99.67 (n)
  • 99.84 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ahcyl2 35
  • 92.02 (n)
  • 97.7 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
-- 36
  • 93 (a)
-- 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia AHCYL2 36
  • 97 (a)
(Gallus gallus)
Aves AHCYL2 35
  • 80.87 (n)
  • 95.2 (a)
  • 98 (a)
(Anolis carolinensis)
Reptilia AHCYL2 36
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ahcyl2 35
  • 76.87 (n)
  • 90.14 (a)
(Danio rerio)
Actinopterygii -- 35
ahcyl2 35
  • 76.76 (n)
  • 87.14 (a)
ahcyl2 36
  • 88 (a)
AHCYL2 (2 of 2) 36
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ahcy89E 35
  • 67.78 (n)
  • 73.94 (a)
Ahcy89E 36
  • 68 (a)
CG9977 36
  • 74 (a)
(Caenorhabditis elegans)
Secernentea ahcy-1 36
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAH1 36
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10842 36
  • 68 (a)
Species with no ortholog for AHCYL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AHCYL2 Gene

Gene Tree for AHCYL2 (if available)
Gene Tree for AHCYL2 (if available)

Paralogs for AHCYL2 Gene

Paralogs for AHCYL2 Gene

(2) SIMAP similar genes for AHCYL2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with AHCYL2: view

Variants for AHCYL2 Gene

Sequence variations from dbSNP and Humsavar for AHCYL2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs12248 -- 129,410,499(-) TAACT(C/T)TGTAG intron-variant
rs721691 -- 129,251,818(-) TAATG(A/G)ACGTA intron-variant
rs822038 -- 129,425,636(-) TCTTA(C/T)ACAAA intron-variant
rs822039 -- 129,425,933(+) GTACT(A/G)TGTAG intron-variant
rs822040 -- 129,426,081(+) CCAAA(C/G)TATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AHCYL2 Gene

Variant ID Type Subtype PubMed ID
nsv831127 CNV Gain 17160897
nsv525482 CNV Loss 19592680
nsv516498 CNV Gain 19592680
esv2735148 CNV Deletion 23290073
nsv831128 CNV Gain 17160897
esv2559463 CNV Insertion 19546169
esv273568 CNV Insertion 20981092
esv268220 CNV Insertion 20981092

Relevant External Links for AHCYL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AHCYL2 Gene

Disorders for AHCYL2 Gene

Relevant External Links for AHCYL2

Genetic Association Database (GAD)

No disorders were found for AHCYL2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for AHCYL2 Gene

Publications for AHCYL2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. (PMID: 20694014) Thye T. … Hill A.V. (Nat. Genet. 2010) 3 48
  3. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. (PMID: 22228203) Aslibekyan S. … Arnett D.K. (Pharmacogenet. Genomics 2012) 3 48
  4. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for AHCYL2 Gene

Sources for AHCYL2 Gene

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