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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AHCYL1 Gene

protein-coding   GIFtS: 63
GCID: GC01P110529

Adenosylhomocysteinase-Like 1

(Previous name: S-adenosylhomocysteine hydrolase-like 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adenosylhomocysteinase-Like 11 2     5-Trisphosphate Receptor-Binding Protein1
AdoHcyase 22 3     Inositol 11
DCAL2 3     S-Adenosylhomocysteine Hydrolase-Like 11
XPVKONA2 3     IRBIT2
DC-Expressed AHCY-Like Molecule2 3     PRO02332
S-Adenosyl-L-Homocysteine Hydrolase 22 3     Dendritic Cell Expressed AHCY-Like Protein2
S-Adenosylhomocysteine Hydrolase-Like Protein 12 3     Inositol 1,4,5-Trisphosphate Receptor-Binding Protein2
EC 3.3.1.13 8     Putative Adenosylhomocysteinase 22
41     S-Adenosyl Homocysteine Hydrolase Homolog2

External Ids:    HGNC: 3441   Entrez Gene: 107682   Ensembl: ENSG000001687107   OMIM: 6078265   UniProtKB: O438653   

Export aliases for AHCYL1 gene to outside databases

Previous GC identifers: GC01P110943 GC01P109393 GC01P109629 GC01P109826 GC01P110239 GC01P110328 GC01P108396


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AHCYL1 Gene:
The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved
in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants
encoding two different isoforms have been found for this gene. (provided by RefSeq, Jun 2011)

GeneCards Summary for AHCYL1 Gene: 
AHCYL1 (adenosylhomocysteinase-like 1) is a protein-coding gene. Diseases associated with AHCYL1 include xeroderma pigmentosum, and tonsillitis, and among its related super-pathways are Sulfur amino acid metabolism and cysteine biosynthesis III (mammalia). GO annotations related to this gene include adenosylhomocysteinase activity and nucleotide binding. An important paralog of this gene is AHCY.

Gene Wiki entry for AHCYL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AHCYL1 gene promoter:
         ISGF-3   AML1a   POU3F2   C/EBPalpha   Roaz   CREB   HFH-1   IRF-7A   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAHCYL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AHCYL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AHCYL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13

AHCYL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AHCYL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P110529:  view genomic region     (about GC identifiers)

Start:
110,527,308 bp from pter      End:
110,566,364 bp from pter
Size:
39,057 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SAHH2_HUMAN, O43865 (See protein sequence)
Recommended Name: Putative adenosylhomocysteinase 2  
Size: 530 amino acids; 58951 Da
Cofactor: Binds 1 NAD per subunit
Subunit: Interacts with ITPR1. Competes with IP3 for interaction with ITPR1 and attenuates IP3-induced Ca(2+)
release through the ITPR1 from the non-mitochondrial intracellular stores (By similarity)
Subcellular location: Endoplasmic reticulum (By similarity)
Developmental stage: Expression increases markedly during activation of blood and skin DC (Langerhans cells), but
is diminished in terminally differentiated tonsil DC
Sequence caution: Sequence=AAC01960.1; Type=Erroneous initiation; Sequence=BI460083; Type=Frameshift;
Positions=Several; Sequence=CAB43223.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for AHCYL1:
3MTG (3D)    
Secondary accessions: B4E168 Q2TAJ6 Q502W8 Q5VSM0 Q6P171 Q96PK4 Q9UG84
Alternative splicing: 2 isoforms:  O43865-1   O43865-2   (Derived from EST data)

Explore the universe of human proteins at neXtProt for AHCYL1: NX_O43865

Explore proteomics data for AHCYL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43865

  • 4/22 DME Specific Peptides for AHCYL1 (O43865) (see all 22)
     EIDPICA  QAKYLGL  QACMDGF  ITEIDPI 

    AHCYL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AHCYL1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001229602.1  NP_001229603.1  NP_001229604.1  NP_001229605.1  NP_006612.2  

    ENSEMBL proteins: 
     ENSP00000358814   ENSP00000352092   ENSP00000377238  

    Human Recombinant Protein Products for AHCYL1: 
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    Novus Biologicals AHCYL1 Proteins
    Novus Biologicals AHCYL1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AHCYL1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--

    AHCYL1 for ontologies           About GeneDecksing



    AHCYL1 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for AHCYL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR020082 S-Ado-L-homoCys_hydrolase_CS
     IPR000043 Adenosylhomocysteinase
     IPR015878 Ado_hCys_hydrolase_NAD-bd
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry O43865

    ProtoNet protein and cluster: O43865

    1 Blocks protein domain: IPB000043 S-adenosyl-L-homocysteine hydrolase

    UniProtKB/Swiss-Prot: SAHH2_HUMAN, O43865
    Domain: The PEST region is essential for the interaction with ITPR1. The PDZ-binding region is required for
    maximal interaction with ITPR1 and is also responsible for the IP3-insensitive interaction with ITPR1 (By
    similarity)
    Similarity: Belongs to the adenosylhomocysteinase family


    AHCYL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAHH2_HUMAN, O43865
    Catalytic activity: S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine

         Genatlas biochemistry entry for AHCYL1:
    S-adenosylhomocysteine hydrolase-like 1

         Enzyme Number (IUBMB): EC 3.3.1.11 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004013adenosylhomocysteinase activity IEA--
    GO:0004455ketol-acid reductoisomerase activity ----
    GO:0005515protein binding IPI--
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----
    GO:0048037cofactor binding ----
         
    AHCYL1 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for AHCYL1:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased homologous recombina 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ahcyl1):
     growth/size 

    AHCYL1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AHCYL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AHCYL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AHCYL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AHCYL1 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidAHCYL1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHCYL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AHCYL1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cysteine and methionine metabolism
    Cysteine and methionine metabolism0.37
    Methionine metabolism0.32
    2methionine degradation I (to homocysteine)
    methionine degradation I (to homocysteine)0.83
    cysteine biosynthesis III (mammalia)0.83
    3Metabolism
    Metabolic pathways0.40
    42-oxobutanoate degradation I
    superpathway of methionine degradation0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for AHCYL1
        Methionine metabolism


    1 GeneGo (Thomson Reuters) Pathway for AHCYL1
        Methionine metabolism

    3 BioSystems Pathways for AHCYL1
        methionine degradation I (to homocysteine)
    superpathway of methionine degradation
    cysteine biosynthesis III (mammalia)


    2         Kegg Pathways  (Kegg details for AHCYL1):
        Cysteine and methionine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: SAHH2_HUMAN, O43865
    Pathway: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step
    1/1


    AHCYL1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AHCYL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/23 Interacting proteins for AHCYL1 (O438651, 3 ENSP000003588144) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP42Q9H9J43, ENSP000003019624I2D: score=2 STRING: ENSP00000301962
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    WDR48Q8TAF33, ENSP000003074914I2D: score=2 STRING: ENSP00000307491
    ITPR1Q146433, ENSP000004059344I2D: score=2 STRING: ENSP00000405934
    HGSO149643, ENSP000003312014I2D: score=1 STRING: ENSP00000331201
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006378mRNA polyadenylation IEA--
    GO:0006611protein export from nucleus IEA--
    GO:0006730one-carbon metabolic process IEA--
    GO:0008652cellular amino acid biosynthetic process ----
    GO:0010765positive regulation of sodium ion transport IEA--

    AHCYL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AHCYL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for AHCYL1 (SAHH2)

    8 HMDB Compounds for AHCYL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)58-61-7--
    Homocysteine(+-)-homocysteine (see all 22)454-29-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    Se-Adenosylselenohomocysteine ----
    SelenohomocysteineSe-selenocysteine (see all 3)29412-93-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 Novoseek inferred chemical compound relationships for AHCYL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-adenosylhomocysteine 92.1 24 16754674 (2), 19805518 (2), 1656997 (1), 10735363 (1) (see all 15)
    deoxyadenosine 64.9 2 7622293 (1), 9495239 (1)

    Search CenterWatch for drugs/clinical trials and news about AHCYL1 / SAHH2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AHCYL1 gene (5 alternative transcripts): 
    NM_001242673.1  NM_001242674.1  NM_001242675.1  NM_001242676.1  NM_006621.5  

    Unigene Cluster for AHCYL1:

    Adenosylhomocysteinase-like 1
    Hs.743973  [show with all ESTs]
    Unigene Representative Sequence: NM_001242673
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369799(uc001dyx.3 uc010ovw.2 uc021ork.1 uc010ovx.2 uc001dyy.3)
    ENST00000475081 ENST00000359172 ENST00000481423 ENST00000469401 ENST00000393614

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    Additional mRNA sequence: 

    AF035319.1 AF315687.1 AK131563.1 AK303690.1 AK308080.1 AK313392.1 AK316110.1 AL049954.1 
    BC003631.2 BC007576.1 BC010681.1 BC016942.1 BC065254.1 BC095476.1 BC110896.1 BC111563.1 
    U82761.1 

    24/29 DOTS entries (see all 29):

    DT.101958184  DT.100057235  DT.97789848  DT.40304277  DT.97813917  DT.65288385  DT.121375881  DT.100877001 
    DT.100876993  DT.92066102  DT.100876997  DT.100059706  DT.100688028  DT.100722270  DT.121375909  DT.92456971 
    DT.100703874  DT.100877002  DT.100877004  DT.121375930  DT.92456959  DT.100876992  DT.100877007  DT.102834566 

    24/696 AceView cDNA sequences (see all 696):

    BU838749 BM453920 AA861012 BE208135 AI868208 BQ026747 CD623005 BQ212518 
    BG259448 BM678463 BU785496 AI224517 AA179561 AU124992 AA836554 BU160309 
    AA984635 AI753466 AA588451 AL553969 AW475019 BE281385 AA382581 CA950612 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for AHCYL1 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12 ^ 13 ^
    SP1:                    -     -     -     -     -                 -     -     -                                                     -                           
    SP2:                                                                                                                                -                           
    SP3:                                                              -     -     -                                                     -                           
    SP4:                    -     -     -     -     -                 -     -     -     -                                                                           
    SP5:                    -           -     -     -                 -     -     -                                                                                 

    ExUns: 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b
    SP1:                                      -                 -     -                     
    SP2:                                                        -     -                     
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for AHCYL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AHCYL1 expression in normal human tissues (normalized intensities)      AHCYL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAGAGCAA
    AHCYL1 Expression
    About this image


    AHCYL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Striatum
             brain/midbrain   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Hair (Integumentary System)
             mouse/organ system/integumental system   

    See AHCYL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AHCYL1

    SOURCE GeneReport for Unigene cluster: Hs.743973

    UniProtKB/Swiss-Prot: SAHH2_HUMAN, O43865
    Tissue specificity: Expressed in dendritic cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for AHCYL1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ahcyl11 , 5 S-adenosylhomocysteine hydrolase-like 11, 5 93.65(n)1
    100(a)1
      3 (46.83 cM)5
    2297091  NM_145542.31  NP_663517.21 
     1076631185 
    chicken
    (Gallus gallus)
    Aves AHCYL11 adenosylhomocysteinase-like 1 84.05(n)
    96.32(a)
      419803  NM_001030913.1  NP_001026084.1 
    lizard
    (Anolis carolinensis)
    Reptilia AHCYL16
    adenosylhomocysteinase-like 1
    98(a)
    1 ↔ 1
    4(106249381-106311243)
    zebrafish
    (Danio rerio)
    Actinopterygii ahcyl11 S-adenosylhomocysteine hydrolase-like 1 79.02(n)
    92.43(a)
      798918  NM_201293.1  NP_958450.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG99773
    Ahcy89E1
    adenosylhomocysteinase3
    Adenosylhomocysteinase 89E1
    78(a)
    (best of 2)3
    67.17(n)1
    71.03(a)1
      62F33
    420431  NM_206500.11  NP_996222.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SAH16
    S-adenosyl-L-homocysteine hydrolase, catabolizes S...
    48(a)
    1 → many
    V(235770-237119)


    ENSEMBL Gene Tree for AHCYL1 (if available)
    TreeFam Gene Tree for AHCYL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AHCYL1 gene
    AHCY2  AHCYL22  
    2 SIMAP similar genes for AHCYL1 using alignment to 4 protein entries:     SAHH2_HUMAN (see all proteins):
    AHCYL2    AHCY

    AHCYL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/743 SNPs in AHCYL1 are shown (see all 743)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs349325161,2
    C--108396917(+) GCTGT-/CTCTGG 2 -- ut510--------
    rs57769981,2
    C,F--108398411(+) GGCTC-/T/TT  
            
    TTTTT
    2 -- int1 trp32NA CSA 4
    rs2012338051,2
    C--108398424(-) CACTTA/TANNNN 2 -- int10--------
    rs2001011551,2
    --108425889(+) TCTTT-/CTTTTT 5 -- int10--------
    rs674819511,2
    C--108427740(+) AAAAT-/CTTTGA 5 -- int10--------
    rs114244311,2
    C--110527452(+) TGCTGC/-TTCTG 2 -- ut512Minor allele frequency- -:0.00NA CSA 4
    rs2012696881,2
    C--110536886(+) GTTTG-/TTTG  
            
    AGATG
    2 -- int10--------
    rs1485004321,2
    C--110542326(+) TTTTT-/TAACCT 3 -- int1 us2k10--------
    rs57769991,2
    C--110550645(+) ttggg-/Tttttt 5 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs107153551,2
    C,F--110551211(+) GACCAT/-TTGCC 5 -- int15Minor allele frequency- -:0.40NA CSA 10

    HapMap Linkage Disequilibrium report for AHCYL1 (110527308 - 110566364 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for AHCYL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv269322CNV Insertion20981092

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607826    OMIM disorders: --

    6 diseases for AHCYL1:    About MalaCards
    xeroderma pigmentosum    tonsillitis    osteosarcoma    cystic fibrosis
    tuberculosis    neuronitis


    AHCYL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AHCYL1

    Export disorders for AHCYL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AHCYL1 gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with AHCYL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling. (PubMed id 16754674)1, 2, 3, 9 Cooper B.J....Kato M. (2006)
    2. Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation. (PubMed id 11904675)1, 2, 3 Dekker J.W.... Kato M. (2002)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. (PubMed id 12878157)1, 2 Imabayashi H.... Umezawa A. (2003)
    6. IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor. (PubMed id 12525476)1, 3 Ando H....Mikoshiba K. (2003)
    7. Characterization of a large population of mRNAs from human testis. (PubMed id 7782076)1, 2 Pawlak A....Guellaen G. (1995)
    8. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    9. Convergence of IRBIT, phosphatidylinositol (4,5) bisph osphate, and WNK/SPAK kinases in regulation of the Na+-HCO3- cotransporters fami ly. (PubMed id 23431199)1 Hong J.H....Muallem S. (2013)
    10. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10768 HGNC: 344 AceView: AHCYL1 Ensembl:ENSG00000168710 euGenes: HUgn10768
    ECgene: AHCYL1 Kegg: 10768 H-InvDB: AHCYL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AHCYL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AHCYL1 gene:
    Search GeneIP for patents involving AHCYL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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