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AHCYL1 Gene

protein-coding   GIFtS: 61
GCID: GC01P110529

Adenosylhomocysteinase-Like 1

(Previous name: S-adenosylhomocysteine hydrolase-like 1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenosylhomocysteinase-Like 11 2     5-Trisphosphate Receptor-Binding Protein1
AdoHcyase 22 3     Inositol 11
DCAL2 3     S-Adenosylhomocysteine Hydrolase-Like 11
XPVKONA2 3     IRBIT2
DC-Expressed AHCY-Like Molecule2 3     PRO02332
S-Adenosyl-L-Homocysteine Hydrolase 22 3     Dendritic Cell Expressed AHCY-Like Protein2
S-Adenosylhomocysteine Hydrolase-Like Protein 12 3     Inositol 1,4,5-Trisphosphate Receptor-Binding Protein2
EC 3.3.1.13 8     Putative Adenosylhomocysteinase 22
41     S-Adenosyl Homocysteine Hydrolase Homolog2

External Ids:    HGNC: 3441   Entrez Gene: 107682   Ensembl: ENSG000001687107   OMIM: 6078265   UniProtKB: O438653   

Export aliases for AHCYL1 gene to outside databases

Previous GC identifers: GC01P110943 GC01P109393 GC01P109629 GC01P109826 GC01P110239 GC01P110328 GC01P108396


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AHCYL1 Gene:
The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved
in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants
encoding two different isoforms have been found for this gene. (provided by RefSeq, Jun 2011)

GeneCards Summary for AHCYL1 Gene:
AHCYL1 (adenosylhomocysteinase-like 1) is a protein-coding gene. GO annotations related to this gene include adenosylhomocysteinase activity. An important paralog of this gene is AHCY.

Gene Wiki entry for AHCYL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the AHCYL1 gene promoter:
         ISGF-3   AML1a   POU3F2   C/EBPalpha   Roaz   CREB   HFH-1   IRF-7A   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAHCYL1 promoter sequence
   Search Chromatin IP Primers for AHCYL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AHCYL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13

AHCYL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AHCYL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P110529:  view genomic region     (about GC identifiers)

Start:
110,527,308 bp from pter      End:
110,566,364 bp from pter
Size:
39,057 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SAHH2_HUMAN, O43865 (See protein sequence)
Recommended Name: Putative adenosylhomocysteinase 2  
Size: 530 amino acids; 58951 Da
Cofactor: Binds 1 NAD per subunit
Subunit: Interacts with ITPR1. Competes with IP3 for interaction with ITPR1 and attenuates IP3-induced Ca(2+)
release through the ITPR1 from the non-mitochondrial intracellular stores (By similarity)
Developmental stage: Expression increases markedly during activation of blood and skin DC (Langerhans cells), but
is diminished in terminally differentiated tonsil DC
Sequence caution: Sequence=AAC01960.1; Type=Erroneous initiation; Sequence=BI460083; Type=Frameshift;
Positions=Several; Sequence=CAB43223.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for AHCYL1:
3MTG (3D)    
Secondary accessions: B4E168 Q2TAJ6 Q502W8 Q5VSM0 Q6P171 Q96PK4 Q9UG84
Alternative splicing: 2 isoforms:  O43865-1   O43865-2   (Derived from EST data)

Explore the universe of human proteins at neXtProt for AHCYL1: NX_O43865

Explore proteomics data for AHCYL1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys377
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for AHCYL1 (O43865) (see all 22)
     EIDPICA  QAKYLGL  QACMDGF  ITEIDPI 


    See AHCYL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001229602.1  NP_001229603.1  NP_001229604.1  NP_001229605.1  NP_006612.2  

    ENSEMBL proteins: 
     ENSP00000358814   ENSP00000352092   ENSP00000377238  

    AHCYL1 Human Recombinant Protein Products:

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    Novus Biologicals AHCYL1 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for AHCYL1

     
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    AHCYL1 Assay Products:

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    Cloud-Clone Corp. ELISAs for AHCYL1
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    Search eBioscience for ELISAs for AHCYL1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000043 Adenosylhomocysteinase
     IPR020082 S-Ado-L-homoCys_hydrolase_CS
     IPR015878 Ado_hCys_hydrolase_NAD-bd
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry O43865

    ProtoNet protein and cluster: O43865

    1 Blocks protein domain: IPB000043 S-adenosyl-L-homocysteine hydrolase

    UniProtKB/Swiss-Prot: SAHH2_HUMAN, O43865
    Domain: The PEST region is essential for the interaction with ITPR1. The PDZ-binding region is required for
    maximal interaction with ITPR1 and is also responsible for the IP3-insensitive interaction with ITPR1 (By
    similarity)
    Similarity: Belongs to the adenosylhomocysteinase family


    Find genes that share domains with AHCYL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAHH2_HUMAN, O43865
    Catalytic activity: S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine

         Genatlas biochemistry entry for AHCYL1:
    S-adenosylhomocysteine hydrolase-like 1

         Enzyme Number (IUBMB): EC 3.3.1.11 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004013adenosylhomocysteinase activity IEA--
    GO:0004455ketol-acid reductoisomerase activity ----
    GO:0005515protein binding IPI--
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----
    GO:0048037cofactor binding ----
         
    Find genes that share ontologies with AHCYL1           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for AHCYL1:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased homologous recombina 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ahcyl1):
     growth/size/body 

    Find genes that share phenotypes with AHCYL1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AHCYL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AHCYL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AHCYL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AHCYL1

    miRNA
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    miRTarBase miRNAs that target AHCYL1:
    hsa-mir-375 (MIRT019871), hsa-mir-92a-3p (MIRT049333), hsa-mir-16-5p (MIRT031633), hsa-mir-1229-3p (MIRT036279), hsa-let-7b-5p (MIRT052133)

    Block miRNA regulation of human, mouse, rat AHCYL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AHCYL1 (see all 50):
    hsa-miR-4291 hsa-miR-3678-3p hsa-miR-642a hsa-miR-25 hsa-miR-938 hsa-miR-502-3p hsa-miR-1276 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidAHCYL1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat AHCYL1

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AHCYL1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AHCYL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SAHH2_HUMAN, O43865: Endoplasmic reticulum (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    chloroplast2
    endoplasmic reticulum2
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with AHCYL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AHCYL1 About    
    See pathways by source

    SuperPathContained pathways About
    1One carbon pool by folate
    Trans-sulfuration and one carbon metabolism0.43
    Methionine metabolism0.35
    2Metabolism
    Metabolic pathways0.38
    3Sulfur amino acid metabolism
    Cysteine and methionine metabolism0.35


    Find genes that share SuperPaths with AHCYL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for AHCYL1
        Methionine metabolism

    1 BioSystems Pathway for AHCYL1
        Trans-sulfuration and one carbon metabolism



    2 Kegg Pathways  (Kegg details for AHCYL1):
        Cysteine and methionine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: SAHH2_HUMAN, O43865
    Pathway: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step
    1/1

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AHCYL1
    Interactions:

        GeneGlobe Interaction Network for AHCYL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AHCYL1 (O438651, 3 ENSP000003588144) via UniProtKB, MINT, STRING, and/or I2D (see all 39)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP42Q9H9J43, ENSP000003019624I2D: score=2 STRING: ENSP00000301962
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    WDR48Q8TAF33, ENSP000003074914I2D: score=2 STRING: ENSP00000307491
    ITPR1Q146433, ENSP000004059344I2D: score=2 STRING: ENSP00000405934
    HGSO149643, ENSP000003312014I2D: score=1 STRING: ENSP00000331201
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006378mRNA polyadenylation IEA--
    GO:0006611protein export from nucleus IEA--
    GO:0006730one-carbon metabolic process IEA--
    GO:0008652cellular amino acid biosynthetic process ----
    GO:0010765positive regulation of sodium ion transport IEA--

    Find genes that share ontologies with AHCYL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AHCYL1 (SAHH2)

    8 HMDB Compounds for AHCYL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)58-61-7--
    Homocysteine(+-)-homocysteine (see all 22)454-29-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    Se-Adenosylselenohomocysteine ----
    SelenohomocysteineSe-selenocysteine (see all 3)29412-93-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 Novoseek inferred chemical compound relationships for AHCYL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-adenosylhomocysteine 92.1 24 16754674 (2), 19805518 (2), 1656997 (1), 10735363 (1) (see all 15)
    deoxyadenosine 64.9 2 7622293 (1), 9495239 (1)



    Find genes that share compounds with AHCYL1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AHCYL1 gene (5 alternative transcripts): 
    NM_001242673.1  NM_001242674.1  NM_001242675.1  NM_001242676.1  NM_006621.5  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369799(uc001dyx.3 uc010ovw.2 uc021ork.1 uc010ovx.2 uc001dyy.3)
    ENST00000475081 ENST00000359172 ENST00000481423 ENST00000469401 ENST00000393614

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate AHCYL1 (see all 50):
    hsa-miR-4291 hsa-miR-3678-3p hsa-miR-642a hsa-miR-25 hsa-miR-938 hsa-miR-502-3p hsa-miR-1276 hsa-miR-298
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      QuantiTect SYBR Green Assays in human, mouse, rat AHCYL1
      QuantiFast Probe-based Assays in human, mouse, rat AHCYL1

    Selected AceView cDNA sequences (see all 696):

    AI868208 AU131962 CD623013 BM453920 BU170543 AI587459 CD108262 AA179561 
    BF432325 AI758131 BQ772895 BU785496 AI967999 CB114554 AI224517 BM750989 
    BC065254 AI950789 BQ896777 AI863147 BQ020652 CR591659 AA454718 AA743807 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AHCYL1 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12 ^ 13 ^
    SP1:                    -     -     -     -     -                 -     -     -                                                     -                           
    SP2:                                                                                                                                -                           
    SP3:                                                              -     -     -                                                     -                           
    SP4:                    -     -     -     -     -                 -     -     -     -                                                                           
    SP5:                    -           -     -     -                 -     -     -                                                                                 

    ExUns: 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b
    SP1:                                      -                 -     -                     
    SP2:                                                        -     -                     
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for AHCYL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AHCYL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAGAGCAA
    AHCYL1 Expression
    About this image


    AHCYL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Kidney (Urinary System)
     
     Uterus (Reproductive System)
    AHCYL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AHCYL1 Protein Expression

    UniProtKB/Swiss-Prot: SAHH2_HUMAN, O43865
    Tissue specificity: Expressed in dendritic cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for AHCYL1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ahcyl11 , 5 S-adenosylhomocysteine hydrolase-like 11, 5 93.65(n)1
    100(a)1
      3 (46.83 cM)5
    2297091  NM_145542.31  NP_663517.21 
     1076631185 
    chicken
    (Gallus gallus)
    Aves AHCYL11 adenosylhomocysteinase-like 1 84.05(n)
    96.32(a)
      419803  NM_001030913.1  NP_001026084.1 
    lizard
    (Anolis carolinensis)
    Reptilia AHCYL16
    adenosylhomocysteinase-like 1
    98(a)
    1 ↔ 1
    4(106249381-106311243)
    zebrafish
    (Danio rerio)
    Actinopterygii ahcyl11 S-adenosylhomocysteine hydrolase-like 1 79.02(n)
    92.43(a)
      798918  NM_201293.1  NP_958450.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG99771 , 3 adenosylhomocysteinase3
    CG99771
    78(a)
    (best of 2)3
    70.35(n)1
    78.81(a)1
      62F33
    383421  NM_139489.21  NP_647746.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ahcy-16
    Protein AHCY-1 (ahcy-1) mRNA, complete cds
    51(a)
    1 → many
    I(6836390-6838142) WBGene00019322
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SAH16
    S-adenosyl-L-homocysteine hydrolase, catabolizes S...
    48(a)
    1 → many
    V(235770-237119) YER043C


    ENSEMBL Gene Tree for AHCYL1 (if available)
    TreeFam Gene Tree for AHCYL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AHCYL1 gene
    AHCY2  AHCYL22  
    2 SIMAP similar genes for AHCYL1 using alignment to 4 protein entries:     SAHH2_HUMAN (see all proteins):
    AHCYL2    AHCY

    Find genes that share paralogs with AHCYL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AHCYL1 (see all 743)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs349325161,2
    C--108396917(+) GCTGT-/CTCTGG 2 -- ut510--------
    rs57769981,2
    C,F--108398411(+) GGCTC-/T/TT  
            
    TTTTT
    2 -- int1 trp32NA CSA 4
    rs2012338051,2
    C--108398424(-) CACTTA/TANNNN 2 -- int10--------
    rs2001011551,2
    --108425889(+) TCTTT-/CTTTTT 5 -- int10--------
    rs674819511,2
    C--108427740(+) AAAAT-/CTTTGA 5 -- int10--------
    rs114244311,2
    C--110527452(+) TGCTGC/-TTCTG 2 -- ut512Minor allele frequency- -:0.00NA CSA 4
    rs2012696881,2
    C--110536886(+) GTTTG-/TTTG  
            
    AGATG
    2 -- int10--------
    rs1485004321,2
    C--110542326(+) TTTTT-/TAACCT 3 -- int1 us2k10--------
    rs57769991,2
    C--110550645(+) ttggg-/Tttttt 5 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs107153551,2
    C,F--110551211(+) GACCAT/-TTGCC 5 -- int15Minor allele frequency- -:0.40NA CSA 10

    HapMap Linkage Disequilibrium report for AHCYL1 (110527308 - 110566364 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for AHCYL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv269322CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AHCYL1
    DNA2.0 Custom Variant and Variant Library Synthesis for AHCYL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607826    OMIM disorders: --


    Find genes that share disorders with AHCYL1           About GenesLikeMe

    Genetic Association Database (GAD): AHCYL1

    Export disorders for AHCYL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AHCYL1 gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with AHCYL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling. (PubMed id 16754674)1, 2, 3, 9 Cooper B.J.... Kato M. (J. Biol. Chem. 2006)
    2. Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation. (PubMed id 11904675)1, 2, 3 Dekker J.W.... Kato M. (Immunogenetics 2002)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. (PubMed id 12878157)1, 2 Imabayashi H.... Umezawa A. (Exp. Cell Res. 2003)
    6. IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor. (PubMed id 12525476)1, 3 Ando H....Mikoshiba K. (J. Biol. Chem. 2003)
    7. Characterization of a large population of mRNAs from human testis. (PubMed id 7782076)1, 2 Pawlak A....Guellaen G. (Genomics 1995)
    8. IRBIT plays an important role in NHE3-mediated pHi regulation in HSG cells. (PubMed id 23769829)1 Tran T.M....Park K. (Biochem. Biophys. Res. Commun. 2013)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10768 HGNC: 344 AceView: AHCYL1 Ensembl:ENSG00000168710 euGenes: HUgn10768
    ECgene: AHCYL1 Kegg: 10768 H-InvDB: AHCYL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AHCYL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AHCYL1 gene:
    Search GeneIP for patents involving AHCYL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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