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AHCY Gene

protein-coding   GIFtS: 69

GC20M032331
S-adenosylhomocysteine hydrolase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
AdoHcyase 3
EC 3.3.1.1 3
OTTHUMP00000030684 2
SAHH 1, 2, 3, 5
adenosylhomocysteinase 2
Descriptions
S-adenosyl-L-homocysteine hydrolase 3
S-adenosylhomocysteine hydrolase 2
External Ids
HGNC: 3431
Entrez Gene: 1912
UniProtKB: P235263
Ensembl: ENSG000001014447
Search outside databases for aliases for AHCY gene

Previous GC identifers: GC20M032626 GC20M033491 GC20M033583

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AHCY:
S-adenosylhomocysteine hydrolase catalyzes the reversible hydrolysis of S-adenosylhomocysteine
(AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular
S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions.
Deficiency in this protein is one of the different causes of hypermethioninemia.
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. [provided by
RefSeq]

UniProtKB/Swiss-Prot: SAHH_HUMAN, P23526
Function: Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent
methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control
of methylations via regulation of the intracellular concentration of adenosylhomocysteine

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the AHCY gene  

Entrez Gene cytogenetic band: 20cen-q13.1   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.22

AHCY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M032331:     (about GC identifiers)

Start:
32,331,737 bp from pter
End:
32,354,811 bp from pter
Size:
23,075 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000020.9  NT_028392.5  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SAHH_HUMAN, P23526 (See protein sequence)
Recommended Name: Adenosylhomocysteinase  
Size: 432 amino acids; 47716 Da
Cofactor: Binds 1 NAD per subunit
Subunit: Homotetramer
Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome
fractions from stage I to stage IV
PDB structure from and Proteopedia :
1A7A (3D)    1LI4 (3D)    
Secondary accessions: Q96A36

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_000678.1  

    ENSEMBL proteins: 
    ENSP00000217426 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (S adenosylhomocysteine hydrolase)
    Human Recombinant Proteins from Abnova (AHCY)
                  OriGene Purified Recombinant Human Protein: AHCY 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm NAS--
    GO:0042470 melanosome IEA--
    About this table

    Antibodies for AHCY: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for AHCY
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (S adenosylhomocysteine hydrolase), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (AHCY)
    Novus Biologicals Antibodies for AHCY

    Assays for AHCY: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR000043 Ad_hcy_hydrolase
     IPR015878 Ado_hCys_hydrolase_NAD-bd


       GeneDecks  AHCY for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P23526

    ProtoNet protein and cluster: P23526

    1 Blocks protein family: IPB000043 S-adenosyl-L-homocysteine hydrolase

    UniProtKB/Swiss-Prot: SAHH_HUMAN, P23526
    Similarity: Belongs to the adenosylhomocysteinase family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (AHCY)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (AHCY)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000687

                  Applied Biosystems Silencer® siRNAs for AHCY

                  Sigma-Aldrich siRNA and siRNA Panels for AHCY  
                         Sigma-Aldrich shRNA for AHCY  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for AHCY
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_000687
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_000687
                                     untagged cDNA clone in CMV expression vector: NM_000687 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_000687

    UniProtKB/Swiss-Prot: SAHH_HUMAN, P23526
    Function: Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent
    methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control
    of methylations via regulation of the intracellular concentration of adenosylhomocysteine
    Catalytic activity: S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine
    Enzyme Number (IUBMB): EC 3.3.1.1 

    Genatlas biochemistry entry for AHCY:
    S-adenosyl-homocysteine hydrolase,sulfur aminoacid metabolism,transmethylation pathway
    1 MGI phenotypic allele for Ahcy (no phenotypes)

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004013 adenosylhomocysteinase activity TAS2596825
    GO:0005515 protein binding IPI17353931
    GO:0016787 hydrolase activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    3 Invitrogen iPath™ Online BioAtlas - Pathways for AHCY (Maps provided by GeneGo):
     Alanine, serine, cysteine, threonine and glycine metabolism
     Methionine metabolism
     Histidine, proline, glutamate and glutamine metabolism

       GeneDecks  AHCY for the pathways selected above  
    About GeneDecksing

    1 Millipore Pathway for AHCY
     Methionine metabolism

       GeneDecks  AHCY for the pathways selected above  
    About GeneDecksing

    3 Sigma-Aldrich "Your Favorite Gene" Pathways for  AHCY  (Your Favorite Gene powered by Ingenuity) 
     Methionine Metabolism
     Aldosterone Signaling in Epithelial Cells
     Selenoamino Acid Metabolism

       GeneDecks  AHCY for the pathways selected above  
    About GeneDecksing

    2 Kegg Pathways  (Kegg details for AHCY):
     hsa00271 Methionine metabolism
     hsa00450 Selenoamino acid metabolism

       GeneDecks  AHCY for the pathways selected above  
    About GeneDecksing
    UniProtKB/Swiss-Prot: SAHH_HUMAN, P23526
    Pathway: Amino-acid biosynthesis; homocysteine biosynthesis; L-homocysteine from
    S-adenosyl-L-homocysteine: step 1/1


    5/36 Interacting proteins for AHCY (P235261, 2 ENSP000002174263) via UniProtKB, MINT, and/or STRING (see all 36 )

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-BP304801EBI-1053240, EBI-1054175
    PINX1Q96BK51EBI-1053240, EBI-721782
    YWHAZP631042MINT-3304654
    MTRENSP000003555353STRING (score=.979)
    CBSENSP000003444603STRING (score=.975)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006730 one-carbon compound metabolic process NAS--
    GO:0008152 metabolic process IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for AHCY
    10/23 Novoseek chemical compound relationships for AHCY gene (see all 23 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-adenosylhomocysteine 98.12 261 18211827 (4), 16061414 (3), 7857307 (3), 16005528 (3) (see all 99)
    3-deazaadenosine 91.53 9 1586132 (1), 1362066 (1), 12910461 (1), 9277463 (1) (see all 6)
    aristeromycin 89.94 5 7857307 (3), 8819518 (1), 12910461 (1)
    s-adenosylmethionine 83.32 22 17688412 (2), 10213491 (2), 15488656 (1), 18769049 (1) (see all 10)
    homocysteine 78.12 21 17688412 (2), 15241484 (1), 16061414 (1), 16149054 (1) (see all 16)
    deoxyadenosine 74.80 3 9478961 (1), 14578314 (1), 1599494 (1)
    nad+ 69.08 8 18393535 (2), 16872278 (1), 15960499 (1), 8416969 (1) (see all 7)
    homocysteine thiolactone 61.50 2 10766176 (1)
    nadh 61.17 2 12590576 (1), 18393535 (1)
    ribose 58.95 3 18066890 (1), 18819082 (1), 12323054 (1)
    About this table

    3 PharmGKB drug compound relationships for AHCY gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    antimetaboliteFA  1586132
    mercaptopurinePD  FA  GN  12704389
    methotrexatePD  FA  GN  12704389
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (AHCY)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (AHCY)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000687

                  Sigma-Aldrich siRNA and siRNA Panels for AHCY  
                         Sigma-Aldrich shRNA for AHCY  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_000687  

    REFSEQ mRNAs for AHCY gene: 

    NM_000687.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_000687  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_000687
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_000687
                                     untagged cDNA clone in CMV expression vector: NM_000687 

    Additional cDNA sequence: 

    AK097610.1 AK290422.1 AK300014.1 AK309204.1 AK316180.1 BC010018.2 BC011606.2 BC114924.1 
    BT006697.1 CR594678.1 CR603449.1 CR603916.1 CR609798.1 CR610700.1 CR613383.1 CR614546.1 
    CR616968.1 CR619776.1 M61831.1 M61832.1 

    24/35 DOTS entries (see all 35 ):

    DT.91775731  DT.100845265  DT.91775733  DT.95277771  DT.91775721  DT.100845260  DT.100845263  DT.100845255 
    DT.100845249  DT.100845239  DT.100845240  DT.100845242  DT.100845247  DT.91775725  DT.120834040  DT.91775715 
    DT.120833987  DT.120834105  DT.435169  DT.95277776  DT.100845245  DT.101976329  DT.91775726  DT.95287622 

    24/976 AceView cDNA sequences (see all 976 ):

    BP358508 BQ055481 BQ653110 BI908170 BM719905 AI144407 BU161697 BI518549 
    BU156754 BM694106 BM766828 BU186467 BU839752 BM905168 BU517126 BM764136 
    AU142242 BM741835 BM460331 AU143174 BQ688034 BP351133 BM475473 BX400110 

    highest scoring ESTs for AHCY:

    M61832 AK097610 AL515030 AL517111 AL517863 AL534662 AL539127 AL546676 AL551545 AL552731 

    Unigene Cluster for AHCY:

    S-adenosylhomocysteine hydrolase
    Hs.388004  [show with all ESTs]
    Unigene Representative Sequence: AK097610


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for AHCY (see all 8 )

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:                          -     -                 -           -                                                                     
    SP2:                          -     -                 -           -                                                                     
    SP3:                                                                                                                          -         
    SP4:                                                  -           -                                                                     
    SP5:                                                                                                                                    

    About this scheme

    ECgene alternative splicing isoforms for AHCY

    1 Ensembl transcript including schematic representation:
    ENST00000217426  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    AHCY expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for AHCY

    1 / 2 / 3

    3 probe-sets matching AHCY gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    40821_at2, 3 U95-A 2 1.00 0.94 1.00 1.00 M61832 1.00 1.00 1.00 1

    200903_s_at2, 3 U133-A 2 1.00 0.95 -- -- NM_000687 0.60 1.00 0.82 1

    200903_s_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
    GeneDecks  AHCY for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.388004

    Expression variation in blood from EXPOLDB for AHCY

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for AHCY gene from 5/28 species (see all 28 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    AHCY1   -- S-adenosylhomocysteine hydrolase 86.88(n)
    92.59(a)
    477198  XM_534388.2  XP_534388.2 
    chimpanzee
    (Pan troglodytes)
    AHCY1   -- S-adenosylhomocysteine hydrolase 99.69(n)
    100(a)
    458190  XM_514594.2  XP_514594.2 
    cow
    (Bos taurus)
    AHCY1   -- S-adenosylhomocysteine hydrolase 92.44(n)
    96.53(a)
    508158  NM_001034315.1  NP_001029487.1 
    rat
    (Rattus norvegicus)
    Ahcy1   -- S-adenosylhomocysteine hydrolase 91.36(n)
    96.53(a)
    29443  NM_017201.1  NP_058897.1 
    mouse
    (Mus musculus)
    Ahcy1, 5 2 (89.00 cM)5
    S-adenosylhomocysteine hydrolase1, 5 91.13(n)1
    96.76(a)1
    2693781  NM_016661.21  NP_057870.21 
     AA9871535  AK0756295  (see all 32)
    About this table        Species with no ortholog for AHCY

    ENSEMBL Gene Tree for AHCY
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for AHCY gene
    AHCYL12  AHCYL22  

    Pseudogenes
    7 related pseudogenes


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/185 NCBI SNPs in AHCY are shown (see all 185 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 61)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 20 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs8191711,2
    A,C,F,O32331645(+) TACCCT/CGTGAA 1 -- ng5110Minor allele frequency- C:0.24MN EA NA CSAM 792
    rs8191461,2
    A,C,F,H32354861(+) TCCTCT/GCACTT 1 -- ng318Minor allele frequency- G:0.33EU EA WA NA 774
    rs42391,2
    C,F,H32331822(-) CTTTCA/TCAACC 1 -- ut31 ese313Minor allele frequency- T:0.09MN NA CSAM EA EU WA 1136
    --
    rs8191691,2
    A,C,F32331698(+) TTGTTA/GGCAGA 1 -- ng519Minor allele frequency- G:0.22MN NA CSAM EA 730
    --
    rs132451,2
    F,H32332200(-) GTCAGT/GAGTGG 1 -- ut31 ese35Minor allele frequency- G:0.01MN EU EA WA 594
    rs8191701,2
    C,H32331665(+) AGCACG/AACTAT 1 -- ng519Minor allele frequency- A:0.00EU EA WA MN CSAM 822
    rs130437521,2
    C,F32346969(+) GTACCG/ACTCCC 1 W/R mis1 ese35Minor allele frequency- A:0.01NA EU EA WA 496
    --
    rs10937821,2
    A32356082(+) cccggG/Tttcaa 1 -- ng310--------
    --
    rs10587941,2
    C32331930(-) AACTGA/CGAAAG 1 -- ut31 ese35Minor allele frequency- C:0.00MN CSAM EA 408
    --
    rs10937831,2
    A32355924(+) ctatgC/Taaatg 1 -- ng31 tfbs30--------
    About this table

    HapMap Linkage Disequilibrium images for AHCY (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 180960

    UniProtKB/Swiss-Prot: SAHH_HUMAN, P23526

  • Defects in AHCY are a cause of hypermethioninemia [MIM:180960]. It is a disease
    characterized by elevated levels of methionine in the sera
  • 10 Novoseek disease relationships for AHCY gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypermethioninemia 87.33 1 18522500 (1)
    hyperhomocysteinemia 60.29 1 16197288 (1)
    parainfluenza 28.06 2 8691433 (1), 10067274 (1)
    severe combined immunodeficiency 23.44 1 14578314 (1)
    leukemia 13.15 1 10439363 (1)
    cancer 2.55 1 18713839 (1)
    immunodeficiency 2.44 4 9708357 (1), 17680812 (1), 9396786 (1)
    necrosis 0.00 2 17624025 (1)
    tumors 0.00 6 18713839 (3), 10067274 (1)
    venous thrombosis 0.00 1 15241484 (1)
    About this table

    1 PharmGKB disease relationship for AHCY gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1PD  FA  GN  12704389
    About this table

    Human Gene Mutation Database: AHCY
    Genetic Association Database: AHCY
    Human Genome Epidemiology Navigator: AHCY (6 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/169 PubMed articles for AHCY gene (see all 169 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 191 HGNC: 343 AceView: AHCY Ensembl:ENSG00000101444 euGenes: HUgn191
    ECgene: AHCY H-InvDB: AHCY
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for AHCY:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for AHCY-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for AHCY Antibodies for AHCY
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for AHCY Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Search for Antibodies & Assays

     Recombinant Proteins
    (S adenosylhomocysteine hydrolase)
     Antibodies (S adenosylhomocysteine hydrolase)
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     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for AHCY




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for AHCY

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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