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AHCY Gene

protein-coding GIFtS: 69

GC20M032331

S-adenosylhomocysteine hydrolase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AdoHcyase ^³
EC 3.3.1.1 ^³
OTTHUMP00000030684 ^²
SAHH ^¹, ², ³, ⁵
adenosylhomocysteinase ^²

Descriptions
S-adenosyl-L-homocysteine hydrolase ^³
S-adenosylhomocysteine hydrolase ^²

External Ids
HGNC: 343¹
Entrez Gene: 191²
UniProtKB: P23526³
Ensembl: ENSG00000101444⁷

Search outside databases for aliases for AHCY gene

Previous GC identifers: GC20M032626 GC20M033491 GC20M033583

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AHCY:

S-adenosylhomocysteine hydrolase catalyzes the reversible hydrolysis of S-adenosylhomocysteine

(AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular

S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions.

Deficiency in this protein is one of the different causes of hypermethioninemia.

S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. [provided by

RefSeq]

UniProtKB/Swiss-Prot: SAHH_HUMAN, P23526

Function: Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent

methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control

of methylations via regulation of the intracellular concentration of adenosylhomocysteine

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AHCY gene

Entrez Gene cytogenetic band: 20cen-q13.1 Ensembl cytogenetic band: 20q11.22 HGNC cytogenetic band: 20q11.22

AHCY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M032331: (about GC identifiers)

Start:	32,331,737 bp from pter
End:	32,354,811 bp from pter
Size:	23,075 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000020.9 NT_028392.5

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SAHH_HUMAN, P23526 (See protein sequence)

Recommended Name: Adenosylhomocysteinase

Size: 432 amino acids; 47716 Da

Cofactor: Binds 1 NAD per subunit

Subunit: Homotetramer

Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome

fractions from stage I to stage IV

PDB structure from and Proteopedia :

1A7A (3D)

1LI4 (3D)

Secondary accessions: Q96A36

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000678.1

ENSEMBL proteins:

ENSP00000217426

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (S adenosylhomocysteine hydrolase)
	Human Recombinant Proteins from Abnova (AHCY)

OriGene Purified Recombinant Human Protein: AHCY

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	NAS	--
GO:0042470	melanosome	IEA	--

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Antibodies for AHCY:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for AHCY
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (S adenosylhomocysteine hydrolase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AHCY)
	Novus Biologicals Antibodies for AHCY

Assays for AHCY:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P23526

ProtoNet protein and cluster: P23526

1 Blocks protein family: IPB000043 S-adenosyl-L-homocysteine hydrolase

UniProtKB/Swiss-Prot: SAHH_HUMAN, P23526

Similarity: Belongs to the adenosylhomocysteinase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AHCY)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AHCY)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000687

Applied Biosystems Silencer® siRNAs for AHCY

Sigma-Aldrich siRNA and siRNA Panels for AHCY

Sigma-Aldrich shRNA for AHCY

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AHCY
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000687
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000687
untagged cDNA clone in CMV expression vector: NM_000687

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000687

UniProtKB/Swiss-Prot: SAHH_HUMAN, P23526

Function: Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent

methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control

of methylations via regulation of the intracellular concentration of adenosylhomocysteine

Catalytic activity: S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine

Enzyme Number (IUBMB): EC 3.3.1.1

Genatlas biochemistry entry for AHCY:

S-adenosyl-homocysteine hydrolase,sulfur aminoacid metabolism,transmethylation pathway

1 MGI phenotypic allele

for Ahcy (no phenotypes)

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004013	adenosylhomocysteinase activity	TAS	2596825
GO:0005515	protein binding	IPI	17353931
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for AHCY (Your Favorite Gene powered by Ingenuity)

Methionine Metabolism
Aldosterone Signaling in Epithelial Cells
Selenoamino Acid Metabolism

GeneDecks AHCY for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: SAHH_HUMAN, P23526

Pathway: Amino-acid biosynthesis; homocysteine biosynthesis; L-homocysteine from

S-adenosyl-L-homocysteine: step 1/1

5/36 Interacting proteins for AHCY (P23526^{1, 2} ENSP00000217426³) via UniProtKB, MINT, and/or STRING (see all 36 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HLA-B	P30480¹	EBI-1053240, EBI-1054175
PINX1	Q96BK5¹	EBI-1053240, EBI-721782
YWHAZ	P63104²	MINT-3304654
MTR	ENSP00000355535³	STRING (score=.979)
CBS	ENSP00000344460³	STRING (score=.975)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006730	one-carbon compound metabolic process	NAS	--
GO:0008152	metabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AHCY
10/23 Novoseek chemical compound relationships for AHCY gene (see all 23 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
s-adenosylhomocysteine	98.12	261	18211827 (4), 16061414 (3), 7857307 (3), 16005528 (3) (see all 99)
3-deazaadenosine	91.53	9	1586132 (1), 1362066 (1), 12910461 (1), 9277463 (1) (see all 6)
aristeromycin	89.94	5	7857307 (3), 8819518 (1), 12910461 (1)
s-adenosylmethionine	83.32	22	17688412 (2), 10213491 (2), 15488656 (1), 18769049 (1) (see all 10)
homocysteine	78.12	21	17688412 (2), 15241484 (1), 16061414 (1), 16149054 (1) (see all 16)
deoxyadenosine	74.80	3	9478961 (1), 14578314 (1), 1599494 (1)
nad+	69.08	8	18393535 (2), 16872278 (1), 15960499 (1), 8416969 (1) (see all 7)
homocysteine thiolactone	61.50	2	10766176 (1)
nadh	61.17	2	12590576 (1), 18393535 (1)
ribose	58.95	3	18066890 (1), 18819082 (1), 12323054 (1)

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3 PharmGKB drug compound relationships for AHCY gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
antimetabolite	FA	1586132
mercaptopurine	PD FA GN	12704389
methotrexate	PD FA GN	12704389

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AHCY)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AHCY)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000687

Sigma-Aldrich siRNA and siRNA Panels for AHCY

Sigma-Aldrich shRNA for AHCY

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000687

REFSEQ mRNAs for AHCY gene:

NM_000687.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000687

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000687
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000687
                                 untagged cDNA clone in CMV expression vector: NM_000687

Additional cDNA sequence:

AK097610.1 AK290422.1 AK300014.1 AK309204.1 AK316180.1 BC010018.2 BC011606.2 BC114924.1

BT006697.1 CR594678.1 CR603449.1 CR603916.1 CR609798.1 CR610700.1 CR613383.1 CR614546.1

CR616968.1 CR619776.1 M61831.1 M61832.1

24/35 DOTS entries (see all 35 ):

DT.91775731 DT.100845265 DT.91775733 DT.95277771 DT.91775721 DT.100845260 DT.100845263 DT.100845255

DT.100845249 DT.100845239 DT.100845240 DT.100845242 DT.100845247 DT.91775725 DT.120834040 DT.91775715

DT.120833987 DT.120834105 DT.435169 DT.95277776 DT.100845245 DT.101976329 DT.91775726 DT.95287622

24/976 AceView cDNA sequences (see all 976 ):

BP358508 BQ055481 BQ653110 BI908170 BM719905 AI144407 BU161697 BI518549

BU156754 BM694106 BM766828 BU186467 BU839752 BM905168 BU517126 BM764136

AU142242 BM741835 BM460331 AU143174 BQ688034 BP351133 BM475473 BX400110

highest scoring ESTs for AHCY:

M61832 AK097610 AL515030 AL517111 AL517863 AL534662 AL539127 AL546676 AL551545 AL552731

Unigene Cluster for AHCY:

S-adenosylhomocysteine hydrolase

Hs.388004 [show with all ESTs]

Unigene Representative Sequence: AK097610

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for AHCY (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13	^	14
SP1:									-		-						-				-
SP2:									-		-						-				-
SP3:																																									-
SP4:																	-				-
SP5:

About this scheme

ECgene alternative splicing isoforms for AHCY

1 Ensembl transcript including schematic representation:

ENST00000217426

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AHCY expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AHCY

¹ / ² / ³

3 probe-sets matching AHCY gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40821_at²^{, 3}	U95-A	2	1.00	0.94	1.00	1.00	M61832	1.00	1.00	1.00	1
200903_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_000687	0.60	1.00	0.82	1
200903_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks AHCY for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.388004
Expression variation in blood from EXPOLDB for AHCY

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AHCY gene from 5/28 species (see all 28 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AHCY¹	--	S-adenosylhomocysteine hydrolase	86.88(n) 92.59(a)	477198 XM_534388.2 XP_534388.2
chimpanzee (Pan troglodytes)	AHCY¹	--	S-adenosylhomocysteine hydrolase	99.69(n) 100(a)	458190 XM_514594.2 XP_514594.2
cow (Bos taurus)	AHCY¹	--	S-adenosylhomocysteine hydrolase	92.44(n) 96.53(a)	508158 NM_001034315.1 NP_001029487.1
rat (Rattus norvegicus)	Ahcy¹	--	S-adenosylhomocysteine hydrolase	91.36(n) 96.53(a)	29443 NM_017201.1 NP_058897.1
mouse (Mus musculus)	Ahcy^{1, 5}	2 (89.00 cM)⁵	S-adenosylhomocysteine hydrolase^{1, 5}	91.13(n)¹ 96.76(a)¹	269378¹ NM_016661.2¹ NP_057870.2¹ AA987153⁵ AK075629⁵ (see all 32)

About this table Species with no ortholog for AHCY

ENSEMBL Gene Tree for AHCY

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AHCY gene

AHCYL1² AHCYL2²

Pseudogenes

7 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/185 NCBI SNPs in AHCY are shown (see all 185 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 61)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs819171^1,2	A,C,F,O	32331645(+)	`TACCCT/CGTGAA`	1	--	ng5¹		10		MN EA NA CSAM	792
	rs819146^1,2	A,C,F,H	32354861(+)	`TCCTCT/GCACTT`	1	--	ng3¹		8		EU EA WA NA	774
	rs4239^1,2	C,F,H	32331822(-)	`CTTTCA/TCAACC`	1	--	ut3¹ ese³		13		MN NA CSAM EA EU WA	1136
--	rs819169^1,2	A,C,F	32331698(+)	`TTGTTA/GGCAGA`	1	--	ng5¹		9		MN NA CSAM EA	730
--	rs13245^1,2	F,H	32332200(-)	`GTCAGT/GAGTGG`	1	--	ut3¹ ese³		5		MN EU EA WA	594
	rs819170^1,2	C,H	32331665(+)	`AGCACG/AACTAT`	1	--	ng5¹		9		EU EA WA MN CSAM	822
	rs13043752^1,2	C,F	32346969(+)	`GTACCG/ACTCCC`	1	W/R	mis¹ ese³		5		NA EU EA WA	496
--	rs1093782^1,2	A	32356082(+)	`cccggG/Tttcaa`	1	--	ng3¹		0	--	--	--	--
--	rs1058794^1,2	C	32331930(-)	`AACTGA/CGAAAG`	1	--	ut3¹ ese³		5		MN CSAM EA	408
--	rs1093783^1,2	A	32355924(+)	`ctatgC/Taaatg`	1	--	ng3¹ tfbs³		0	--	--	--	--

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HapMap Linkage Disequilibrium images for AHCY (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 180960

UniProtKB/Swiss-Prot: SAHH_HUMAN, P23526

Defects in AHCY are a cause of hypermethioninemia [MIM:180960]. It is a disease

characterized by elevated levels of methionine in the sera

10 Novoseek disease relationships for AHCY gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hypermethioninemia	87.33	1	18522500 (1)
hyperhomocysteinemia	60.29	1	16197288 (1)
parainfluenza	28.06	2	8691433 (1), 10067274 (1)
severe combined immunodeficiency	23.44	1	14578314 (1)
leukemia	13.15	1	10439363 (1)
cancer	2.55	1	18713839 (1)
immunodeficiency	2.44	4	9708357 (1), 17680812 (1), 9396786 (1)
necrosis	0.00	2	17624025 (1)
tumors	0.00	6	18713839 (3), 10067274 (1)
venous thrombosis	0.00	1	15241484 (1)

About this table

1 PharmGKB disease relationship for AHCY gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12704389

About this table

Human Gene Mutation Database: AHCY
Genetic Association Database: AHCY
Human Genome Epidemiology Navigator: AHCY (6 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/169 PubMed articles for AHCY gene (see all 169 ):

Effect of genetic variation in the human S-adenosylhomocysteine hydrolase gene on total homocysteine concentrations and risk of recurrent venous thrombosis. (PubMed id 15241484)^{1, 3, 6} Gellekink H....Blom H.J. (2004)
Limited proteolysis of S-adenosylhomocysteine hydrolase: implications for the three-dimensional structure. (PubMed id 7786017)^{1, 3, 4} Gupta R.A.... Borchardt R.T. (1995)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{3, 4} Chi A....Hunt D.F. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength. (PubMed id 9586999)^{3, 4} Turner M.A....Howell P.L. (1998)
Photoaffinity labeling of human placental S-adenosylhomocysteine hydrolase with [2-3H]8-azido-adenosine. (PubMed id 7608178)^{3, 4} Yuan C.S. and Borchardt R.T. (1995)
Kinetic properties of the common electrophoretic variants of human S-adenosylhomocysteine hydrolase (AHCY): the effect of four nucleoside analogue inhibitors. (PubMed id 1586132)^{1, 7} Corbo R.M....Bozzi A. (1992)
Sequence of full length cDNA for human S-adenosylhomocysteine hydrolase. (PubMed id 2596825)^{3, 4} Coulter-Karis D.E. and Hershfield M.S. (1989)
Isozyme and DNA analysis of human S-adenosyl-L-homocysteine hydrolase (AHCY). (PubMed id 2574561)^{3, 4} Arredondo-Vega F.X....Whitehouse D.B. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 191	HGNC: 343	AceView: AHCY	Ensembl:ENSG00000101444	euGenes: HUgn191
ECgene: AHCY	H-InvDB: AHCY

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for AHCY
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AHCY:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AHCY-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AHCY		Antibodies for AHCY
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AHCY		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
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	Recombinant Proteins (AHCY)
	Antibodies (AHCY)
	Chimera RNAi (AHCY)
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	Recombinant Proteins (S adenosylhomocysteine hydrolase)
	Antibodies (S adenosylhomocysteine hydrolase)

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	Western blot validated antibodies
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Antibodies for AHCY

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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AHCY Gene at Home site.
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AHCY Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for AHCY

Summaries
for AHCY

Genomic Location
for AHCY

Proteins
for AHCY

Protein Domains/
Families
for AHCY

Gene Function
for AHCY

Pathways & Interactions
for AHCY

Drugs & Compounds
for AHCY

Transcripts
for AHCY

Expression
for AHCY

Orthologs
for AHCY

Paralogs
for AHCY

SNPs/Variants
for AHCY

Disorders & Mutations
for AHCY

Medical News
for AHCY

Publications
for AHCY

Search for AHCY

Genome Databases showing AHCY

Other Databases showing AHCY

Specialized Databases showing AHCY

Licensable Technologies
for AHCY

Services
for AHCY

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AHCY Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor AHCY

Summariesfor AHCY

Genomic Locationfor AHCY

Proteinsfor AHCY

Protein Domains/Familiesfor AHCY

Gene Functionfor AHCY

Pathways & Interactionsfor AHCY

Drugs & Compoundsfor AHCY

Transcriptsfor AHCY

Expression for AHCY

Orthologsfor AHCY

Paralogsfor AHCY

SNPs/Variantsfor AHCY

Disorders & Mutationsfor AHCY

Medical Newsfor AHCY

Publicationsfor AHCY

Search for AHCY

Genome Databases showing AHCY

Other Databases showing AHCY

Specialized Databases showing AHCY

Licensable Technologiesfor AHCY

Servicesfor AHCY

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AHCY

Summaries
for AHCY

Genomic Location
for AHCY

Proteins
for AHCY

Protein Domains/
Families
for AHCY

Gene Function
for AHCY

Pathways & Interactions
for AHCY

Drugs & Compounds
for AHCY

Transcripts
for AHCY

Expression
for AHCY

Orthologs
for AHCY

Paralogs
for AHCY

SNPs/Variants
for AHCY

Disorders & Mutations
for AHCY

Medical News
for AHCY

Publications
for AHCY

Licensable Technologies
for AHCY

Services
for AHCY