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Aliases for AHCTF1 Gene

Aliases for AHCTF1 Gene

  • AT Hook Containing Transcription Factor 1 2 3
  • ELYS 3 4 6
  • Putative AT-Hook-Containing Transcription Factor 1 3 4
  • Embryonic Large Molecule Derived From Yolk Sac 3 4
  • ELYS Transcription Factor Like Protein TMBS62 2 3
  • TMBS62 3 4
  • ELYS Transcription Factor-Like Protein TMBS62 3
  • Protein MEL-28 4
  • Protein ELYS 3
  • MSTP108 3
  • MST108 3

External Ids for AHCTF1 Gene

Summaries for AHCTF1 Gene

GeneCards Summary for AHCTF1 Gene

AHCTF1 (AT Hook Containing Transcription Factor 1) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot for AHCTF1 Gene

  • Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis.

Gene Wiki entry for AHCTF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AHCTF1 Gene

Genomics for AHCTF1 Gene

Genomic Location for AHCTF1 Gene

Start:
246,839,098 bp from pter
End:
246,931,978 bp from pter
Size:
92,881 bases
Orientation:
Minus strand

Genomic View for AHCTF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AHCTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AHCTF1 Gene

Regulatory Elements for AHCTF1 Gene

Proteins for AHCTF1 Gene

  • Protein details for AHCTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYP5-ELYS_HUMAN
    Recommended name:
    Protein ELYS
    Protein Accession:
    Q8WYP5
    Secondary Accessions:
    • A6NGM0
    • A8MSG9
    • A8MZ86
    • Q7Z4E3
    • Q8IZA4
    • Q96EH9
    • Q9Y4Q6

    Protein attributes for AHCTF1 Gene

    Size:
    2266 amino acids
    Molecular mass:
    252498 Da
    Quaternary structure:
    • Associates with the Nup107-160 subcomplex of the NPC
    SequenceCaution:
    • Sequence=AAN65622.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAQ13621.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB78516.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for AHCTF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AHCTF1 Gene

Proteomics data for AHCTF1 Gene at MOPED

Post-translational modifications for AHCTF1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys42, Lys505, Lys717, Lys969, Lys1002, Lys1069, Lys1141, and Lys1158

Other Protein References for AHCTF1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for AHCTF1 Gene

Domains for AHCTF1 Gene

Protein Domains for AHCTF1 Gene

Suggested Antigen Peptide Sequences for AHCTF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WYP5

UniProtKB/Swiss-Prot:

ELYS_HUMAN
Domain:
  • The N-terminus forms a highly conserved seven-bladed beta propeller decorated with long loops and mediates anchorage to the Nup107-160 subcomplex of the nuclear pore, synergistically with the central alpha domain. The disordered C-terminus is responsible for the interactions with chromatin (By similarity).:
    • Q8WYP5
  • Contains 1 A.T hook DNA-binding domain.:
    • Q8WYP5
Family:
  • Belongs to the ELYS family.:
    • Q8WYP5
genes like me logo Genes that share domains with AHCTF1: view

No data available for Gene Families for AHCTF1 Gene

Function for AHCTF1 Gene

Molecular function for AHCTF1 Gene

UniProtKB/Swiss-Prot Function: Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis.

Gene Ontology (GO) - Molecular Function for AHCTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with AHCTF1: view
genes like me logo Genes that share phenotypes with AHCTF1: view

Animal Models for AHCTF1 Gene

MGI Knock Outs for AHCTF1:

miRNA for AHCTF1 Gene

miRTarBase miRNAs that target AHCTF1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AHCTF1 Gene

Localization for AHCTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AHCTF1 Gene

Cytoplasm. Nucleus matrix. Chromosome, centromere, kinetochore. Nucleus, nucleoplasm. Nucleus, nuclear pore complex. Note=Localizes to the nuclear pore complex (NPC) throughout interphase. Localizes to the kinetochore from prophase, and this appears to require the Nup107-160 subcomplex of the NPC. Localizes to the periphery of chromatin from late anaphase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AHCTF1 Gene COMPARTMENTS Subcellular localization image for AHCTF1 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AHCTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000777 colocalizes_with condensed chromosome kinetochore IDA 17098863
GO:0000785 colocalizes_with chromatin IDA 17098863
GO:0005634 nucleus IDA --
GO:0005643 colocalizes_with nuclear pore IDA 17098863
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with AHCTF1: view

Pathways for AHCTF1 Gene

genes like me logo Genes that share pathways with AHCTF1: view

Pathways by source for AHCTF1 Gene

Gene Ontology (GO) - Biological Process for AHCTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0000910 cytokinesis IMP 17098863
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with AHCTF1: view

Transcripts for AHCTF1 Gene

Unigene Clusters for AHCTF1 Gene

AT hook containing transcription factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AHCTF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for AHCTF1 Gene

GeneLoc Exon Structure for
AHCTF1
ECgene alternative splicing isoforms for
AHCTF1

Expression for AHCTF1 Gene

mRNA expression in normal human tissues for AHCTF1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AHCTF1 Gene

SOURCE GeneReport for Unigene cluster for AHCTF1 Gene Hs.300887

genes like me logo Genes that share expressions with AHCTF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AHCTF1 Gene

Orthologs for AHCTF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for AHCTF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AHCTF1 35
  • 97.94 (n)
  • 97.17 (a)
cow
(Bos Taurus)
Mammalia AHCTF1 35
  • 86.69 (n)
  • 81.34 (a)
AHCTF1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AHCTF1 35
  • 80.3 (n)
  • 72.2 (a)
AHCTF1 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ahctf1 35
  • 78.64 (n)
  • 72.07 (a)
Ahctf1 16
Ahctf1 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AHCTF1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AHCTF1 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ahctf1 35
  • 78.49 (n)
  • 71.49 (a)
chicken
(Gallus gallus)
Aves AHCTF1 35
  • 66.53 (n)
  • 60.23 (a)
AHCTF1 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AHCTF1 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ahctf1 35
  • 68.56 (n)
  • 67.07 (a)
zebrafish
(Danio rerio)
Actinopterygii ahctf1 36
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14215 36
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
Species with no ortholog for AHCTF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AHCTF1 Gene

ENSEMBL:
Gene Tree for AHCTF1 (if available)
TreeFam:
Gene Tree for AHCTF1 (if available)

Paralogs for AHCTF1 Gene

Pseudogenes.org Pseudogenes for AHCTF1 Gene

genes like me logo Genes that share paralogs with AHCTF1: view

No data available for Paralogs for AHCTF1 Gene

Variants for AHCTF1 Gene

Sequence variations from dbSNP and Humsavar for AHCTF1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs768197 -- 246,923,930(-) CCTCT(G/T)CTCAG intron-variant
rs903462 -- 246,932,608(-) AGCAC(C/G)GTGGA upstream-variant-2KB
rs903464 -- 246,907,921(+) GAAAA(C/T)TGCCA intron-variant
rs903465 -- 246,908,051(+) AAATA(A/G)AACTG intron-variant
rs923972 -- 246,916,871(+) AACGA(C/T)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AHCTF1 Gene

Variant ID Type Subtype PubMed ID
esv2667587 CNV Deletion 23128226
nsv873421 CNV Gain 21882294
nsv873422 CNV Gain 21882294
nsv509768 CNV Insertion 20534489
nsv873424 CNV Gain 21882294
nsv511751 CNV Loss 21212237
esv2446831 CNV Deletion 19546169
esv1940734 CNV Deletion 18987734
esv2857 CNV Deletion 18987735
esv2727607 CNV Deletion 23290073
esv2665105 CNV Deletion 23128226
nsv5276 CNV Loss 18451855
esv2727618 CNV Deletion 23290073
dgv561n71 CNV Gain 21882294
esv33129 CNV Gain+Loss 17666407

Relevant External Links for AHCTF1 Gene

HapMap Linkage Disequilibrium report
AHCTF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AHCTF1 Gene

Disorders for AHCTF1 Gene

No disorders were found for AHCTF1 Gene.

No data available for UniProtKB/Swiss-Prot for AHCTF1 Gene

Publications for AHCTF1 Gene

  1. Identification of a novel transcription factor, ELYS, expressed predominantly in mouse foetal haematopoietic tissues. (PMID: 11952839) Kimura N. … Taga T. (Genes Cells 2002) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division. (PMID: 17098863) Rasala B.A. … Forbes D.J. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4

Products for AHCTF1 Gene

Sources for AHCTF1 Gene

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