Aliases for AGXT2 Gene
External Ids for AGXT2 Gene
Previous GeneCards Identifiers for AGXT2 Gene
The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. [provided by RefSeq, Dec 2008]
GeneCards Summary for AGXT2 Gene
AGXT2 (Alanine--Glyoxylate Aminotransferase 2) is a Protein Coding gene. Diseases associated with AGXT2 include primary hyperoxaluria. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include pyridoxal phosphate binding and beta-alanine-pyruvate transaminase activity. An important paralog of this gene is ETNPPL.
UniProtKB/Swiss-Prot for AGXT2 Gene
Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.