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Aliases for AGXT2 Gene

Aliases for AGXT2 Gene

  • Alanine--Glyoxylate Aminotransferase 2 2 3
  • Beta-Alanine-Pyruvate Aminotransferase 2 3 4
  • Beta-ALAAT II 2 3 4
  • AGT2 3 4 6
  • (R)-3-Amino-2-Methylpropionate--Pyruvate Transaminase 3 4
  • Alanine--Glyoxylate Aminotransferase 2, Mitochondrial 3
  • Alanine-Glyoxylate Aminotransferase 2 2
  • EC 2.6.1.44 4
  • EC 2.6.1.40 4
  • D-AIBAT 4
  • DAIBAT 3
  • AGT 2 4

External Ids for AGXT2 Gene

Summaries for AGXT2 Gene

Entrez Gene Summary for AGXT2 Gene

  • The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. [provided by RefSeq, Dec 2008]

GeneCards Summary for AGXT2 Gene

AGXT2 (Alanine--Glyoxylate Aminotransferase 2) is a Protein Coding gene. Diseases associated with AGXT2 include primary hyperoxaluria. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include pyridoxal phosphate binding and beta-alanine-pyruvate transaminase activity. An important paralog of this gene is ETNPPL.

UniProtKB/Swiss-Prot for AGXT2 Gene

  • Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGXT2 Gene

Genomics for AGXT2 Gene

Genomic Location for AGXT2 Gene

Start:
34,998,101 bp from pter
End:
35,048,188 bp from pter
Size:
50,088 bases
Orientation:
Minus strand

Genomic View for AGXT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGXT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGXT2 Gene

Regulatory Elements for AGXT2 Gene

Proteins for AGXT2 Gene

  • Protein details for AGXT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYV1-AGT2_HUMAN
    Recommended name:
    Alanine--glyoxylate aminotransferase 2, mitochondrial
    Protein Accession:
    Q9BYV1
    Secondary Accessions:
    • B7ZM47
    • E9PDL7
    • Q53FB4
    • Q53FY7
    • Q53G03
    • Q5W7Q1

    Protein attributes for AGXT2 Gene

    Size:
    514 amino acids
    Molecular mass:
    57156 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homotetramer.

    Alternative splice isoforms for AGXT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGXT2 Gene

Proteomics data for AGXT2 Gene at MOPED

Post-translational modifications for AGXT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGXT2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for AGXT2 Gene

Domains for AGXT2 Gene

UniProtKB/Swiss-Prot:

AGT2_HUMAN
Family:
  • Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.:
    • Q9BYV1
genes like me logo Genes that share domains with AGXT2: view

No data available for Gene Families for AGXT2 Gene

Function for AGXT2 Gene

Molecular function for AGXT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: L-alanine + glyoxylate = pyruvate + glycine
UniProtKB/Swiss-Prot CatalyticActivity: (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
UniProtKB/Swiss-Prot Function: Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.

Enzyme Numbers (IUBMB) for AGXT2 Gene

Gene Ontology (GO) - Molecular Function for AGXT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008453 alanine-glyoxylate transaminase activity TAS --
GO:0008483 transaminase activity --
GO:0016223 beta-alanine-pyruvate transaminase activity IEA --
GO:0030170 pyridoxal phosphate binding IEA --
GO:0047305 (R)-3-amino-2-methylpropionate-pyruvate transaminase activity IEA --
genes like me logo Genes that share ontologies with AGXT2: view

Phenotypes for AGXT2 Gene

GenomeRNAi human phenotypes for AGXT2:
genes like me logo Genes that share phenotypes with AGXT2: view

miRNA for AGXT2 Gene

miRTarBase miRNAs that target AGXT2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for AGXT2 Gene

Localization for AGXT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGXT2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGXT2 Gene COMPARTMENTS Subcellular localization image for AGXT2 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AGXT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 20018850
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with AGXT2: view

Pathways for AGXT2 Gene

genes like me logo Genes that share pathways with AGXT2: view

Interacting Proteins for AGXT2 Gene

Gene Ontology (GO) - Biological Process for AGXT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006206 pyrimidine nucleobase metabolic process TAS --
GO:0009436 glyoxylate catabolic process IDA 20018850
GO:0019265 glycine biosynthetic process, by transamination of glyoxylate IDA 20018850
GO:0019481 L-alanine catabolic process, by transamination IDA 20018850
GO:0034641 cellular nitrogen compound metabolic process TAS --
genes like me logo Genes that share ontologies with AGXT2: view

Compounds for AGXT2 Gene

(9) HMDB Compounds for AGXT2 Gene

Compound Synonyms Cas Number PubMed IDs
2-Methyl-3-oxopropanoic acid
  • 2-Methyl-3-oxopropanoate
6236-08-4
Famotidine
  • Amfamox
76824-35-6
Glycine
  • 2-Aminoacetate
56-40-6
Glyoxylic acid
  • Formylformate
298-12-4
L-Alanine
  • (2S)-2-Aminopropanoate
56-41-7

(4) Drugbank Compounds for AGXT2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Glycine
  • 2-Aminoacetic acid
56-40-6 target
L-Alanine
  • (2S)-2-Aminopropanoic acid
56-41-7 target
Pyridoxal Phosphate
  • Codecarboxylase
54-47-7 target cofactor
Pyruvic acid
  • 2-Oxopropanoate
127-17-3 target
genes like me logo Genes that share compounds with AGXT2: view

Transcripts for AGXT2 Gene

Unigene Clusters for AGXT2 Gene

Alanine--glyoxylate aminotransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGXT2 Gene

No ASD Table

Relevant External Links for AGXT2 Gene

GeneLoc Exon Structure for
AGXT2
ECgene alternative splicing isoforms for
AGXT2

Expression for AGXT2 Gene

mRNA expression in normal human tissues for AGXT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGXT2 Gene

This gene is overexpressed in Liver (29.2) and Kidney - Cortex (23.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for AGXT2 Gene

SOURCE GeneReport for Unigene cluster for AGXT2 Gene Hs.34494

genes like me logo Genes that share expressions with AGXT2: view

Orthologs for AGXT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AGXT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGXT2 36
  • 99.42 (n)
  • 99.22 (a)
AGXT2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AGXT2 36
  • 86.64 (n)
  • 86.19 (a)
AGXT2 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGXT2 36
  • 86.29 (n)
  • 84.8 (a)
AGXT2 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agxt2 36
  • 84.47 (n)
  • 84.99 (a)
Agxt2 16
Agxt2 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGXT2 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 74 (a)
OneToMany
-- 37
  • 73 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Agxt2 36
  • 83.98 (n)
  • 83.4 (a)
chicken
(Gallus gallus)
Aves AGXT2 36
  • 71.4 (n)
  • 69.94 (a)
AGXT2 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGXT2 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agxt2 36
  • 65.41 (n)
  • 65.69 (a)
zebrafish
(Danio rerio)
Actinopterygii agxt2 36
  • 60.53 (n)
  • 57.82 (a)
agxt2 37
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012404 36
  • 56.43 (n)
  • 54.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11241 36
  • 56.56 (n)
  • 55.7 (a)
CG11241 37
  • 50 (a)
OneToOne
CG11241 38
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea T09B4.8 36
  • 57.29 (n)
  • 54.14 (a)
T09B4.8 37
  • 52 (a)
OneToOne
T09B4.8 38
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARG8 37
  • 27 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3270 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AGT2 36
  • 54.39 (n)
  • 48.28 (a)
rice
(Oryza sativa)
Liliopsida Os03g0171900 36
  • 52.97 (n)
  • 46.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 52 (a)
OneToOne
Species with no ortholog for AGXT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGXT2 Gene

ENSEMBL:
Gene Tree for AGXT2 (if available)
TreeFam:
Gene Tree for AGXT2 (if available)

Paralogs for AGXT2 Gene

Paralogs for AGXT2 Gene

Selected SIMAP similar genes for AGXT2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with AGXT2: view

Variants for AGXT2 Gene

Sequence variations from dbSNP and Humsavar for AGXT2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs28305 -- 35,044,193(-) CAAAC(C/G)TCAAT intron-variant
rs37368 -- 35,036,892(+) TCATA(C/T)CTTTT intron-variant
rs37369 - 35,037,010(+) GAAGA(C/T)GGTGC missense, reference
rs37370 -, -, - 35,039,381(+) ATCTG(A/C/G/T)TTCCT missense, reference
rs37371 -- 35,040,125(+) AAAGT(A/G)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGXT2 Gene

Variant ID Type Subtype PubMed ID
nsv881607 CNV Loss 21882294
dgv6032n71 CNV Gain 21882294

Relevant External Links for AGXT2 Gene

HapMap Linkage Disequilibrium report
AGXT2
Human Gene Mutation Database (HGMD)
AGXT2

Disorders for AGXT2 Gene

(1) MalaCards Diseases for AGXT2 Gene

Search for AGXT2 Gene in MalaCards »

Relevant External Links for AGXT2

Genetic Association Database (GAD)
AGXT2
Human Genome Epidemiology (HuGE) Navigator
AGXT2
genes like me logo Genes that share disorders with AGXT2: view

No data available for UniProtKB/Swiss-Prot for AGXT2 Gene

Publications for AGXT2 Gene

  1. Glycolate and glyoxylate metabolism in HepG2 cells. (PMID: 15240345) Baker P.R. … Holmes R.P. (Am. J. Physiol., Cell Physiol. 2004) 2 3 23 25
  2. Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production. (PMID: 20018850) Rodionov R.N. … Lentz S.R. (J. Biol. Chem. 2010) 3 4 23
  3. Molecular cloning and sequencing of a cDNA encoding alanine- glyoxylate aminotransferase 2 from rat kidney. (PMID: 7592550) Matsui-Lee I.S. … Kido R. (J. Biochem. 1995) 3 23 25
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  5. A genome-wide association study of metabolic traits in human urine. (PMID: 21572414) Suhre K. … Nauck M. (Nat. Genet. 2011) 3 49

Products for AGXT2 Gene

Sources for AGXT2 Gene

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