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Aliases for AGXT2 Gene

Aliases for AGXT2 Gene

  • Alanine--Glyoxylate Aminotransferase 2 2 3 5
  • Beta-Alanine-Pyruvate Aminotransferase 2 3 4
  • Beta-ALAAT II 2 3 4
  • (R)-3-Amino-2-Methylpropionate--Pyruvate Transaminase 3 4
  • AGT2 3 4
  • Alanine-Glyoxylate Aminotransferase 2 2
  • EC 2.6.1.44 4
  • EC 2.6.1.40 4
  • D-AIBAT 4
  • DAIBAT 3
  • AGT 2 4

External Ids for AGXT2 Gene

Previous GeneCards Identifiers for AGXT2 Gene

  • GC05M035031
  • GC05M036024
  • GC05M035043

Summaries for AGXT2 Gene

Entrez Gene Summary for AGXT2 Gene

  • The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. It is an important regulator of methylarginines and is involved in the control of blood pressure in kidney. Polymorphisms in this gene affect methylarginine and beta-aminoisobutyrate metabolism, and are associated with carotid atherosclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for AGXT2 Gene

AGXT2 (Alanine--Glyoxylate Aminotransferase 2) is a Protein Coding gene. Among its related pathways are Alanine, aspartate and glutamate metabolism and Sulfur amino acid metabolism. GO annotations related to this gene include pyridoxal phosphate binding and alanine-glyoxylate transaminase activity. An important paralog of this gene is ETNPPL.

UniProtKB/Swiss-Prot for AGXT2 Gene

  • Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGXT2 Gene

Genomics for AGXT2 Gene

Regulatory Elements for AGXT2 Gene

Enhancers for AGXT2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AGXT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for AGXT2 Gene

Chromosome:
5
Start:
34,998,101 bp from pter
End:
35,048,188 bp from pter
Size:
50,088 bases
Orientation:
Minus strand

Genomic View for AGXT2 Gene

Genes around AGXT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGXT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGXT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGXT2 Gene

Proteins for AGXT2 Gene

  • Protein details for AGXT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYV1-AGT2_HUMAN
    Recommended name:
    Alanine--glyoxylate aminotransferase 2, mitochondrial
    Protein Accession:
    Q9BYV1
    Secondary Accessions:
    • B7ZM47
    • E9PDL7
    • Q53FB4
    • Q53FY7
    • Q53G03
    • Q5W7Q1

    Protein attributes for AGXT2 Gene

    Size:
    514 amino acids
    Molecular mass:
    57156 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homotetramer.

    Alternative splice isoforms for AGXT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGXT2 Gene

Proteomics data for AGXT2 Gene at MOPED

Post-translational modifications for AGXT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGXT2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for AGXT2

No data available for DME Specific Peptides for AGXT2 Gene

Domains & Families for AGXT2 Gene

Suggested Antigen Peptide Sequences for AGXT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYV1

UniProtKB/Swiss-Prot:

AGT2_HUMAN :
  • Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
Family:
  • Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
genes like me logo Genes that share domains with AGXT2: view

No data available for Gene Families for AGXT2 Gene

Function for AGXT2 Gene

Molecular function for AGXT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
L-alanine + glyoxylate = pyruvate + glycine.
UniProtKB/Swiss-Prot CatalyticActivity:
(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine.
UniProtKB/Swiss-Prot Function:
Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.

Enzyme Numbers (IUBMB) for AGXT2 Gene

genes like me logo Genes that share phenotypes with AGXT2: view

Animal Models for AGXT2 Gene

MGI Knock Outs for AGXT2:

Animal Model Products

  • Taconic Biosciences Mouse Models for AGXT2

miRNA for AGXT2 Gene

miRTarBase miRNAs that target AGXT2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AGXT2 Gene

Localization for AGXT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGXT2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGXT2 Gene COMPARTMENTS Subcellular localization image for AGXT2 gene
Compartment Confidence
mitochondrion 5
cytosol 2
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for AGXT2 Gene

Pathways & Interactions for AGXT2 Gene

genes like me logo Genes that share pathways with AGXT2: view

Interacting Proteins for AGXT2 Gene

Gene Ontology (GO) - Biological Process for AGXT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0046487 glyoxylate metabolic process TAS --
genes like me logo Genes that share ontologies with AGXT2: view

No data available for SIGNOR curated interactions for AGXT2 Gene

Drugs & Compounds for AGXT2 Gene

(7) Drugs for AGXT2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved Nutra Full agonist, Agonist, Target Endogenous potentiator, co-transmitter 197
L-Alanine Approved Nutra Full agonist, Agonist, Target Glycine receptor agonist 0
Pyruvic acid Approved Nutra Target 0
Famotidine Approved Pharma Histamine H2-receptor antagonist 57
Glyoxylic acid Experimental Pharma 0

(3) Additional Compounds for AGXT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(R)-b-aminoisobutyric acid
  • (-)-b-Aminoisobutyrate
  • (-)-b-Aminoisobutyric acid
  • (-)-beta-Aminoisobutyrate
  • (-)-beta-Aminoisobutyric acid
  • (2R)-3-amino-2-methyl-Propanoate
2140-95-6
2-Methyl-3-oxopropanoic acid
  • 2-Methyl-3-oxopropanoate
  • 2-Methyl-3-oxopropanoic acid
  • 3-Oxo-2-methylpropanoate
  • 3-Oxo-2-methylpropanoic acid
  • Ch3-malonate-semialdehyde
6236-08-4
Oxoglutaric acid
  • 2-Ketoglutarate
  • 2-Ketoglutaric acid
  • 2-Oxo-1,5-pentanedioate
  • 2-Oxo-1,5-pentanedioic acid
  • 2-Oxoglutarate
328-50-7
genes like me logo Genes that share compounds with AGXT2: view

Transcripts for AGXT2 Gene

Unigene Clusters for AGXT2 Gene

Alanine--glyoxylate aminotransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGXT2 Gene

No ASD Table

Relevant External Links for AGXT2 Gene

GeneLoc Exon Structure for
AGXT2
ECgene alternative splicing isoforms for
AGXT2

Expression for AGXT2 Gene

mRNA expression in normal human tissues for AGXT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGXT2 Gene

This gene is overexpressed in Liver (x29.2) and Kidney - Cortex (x23.3).

Protein differential expression in normal tissues from HIPED for AGXT2 Gene

This gene is overexpressed in Kidney (33.1), Gallbladder (19.7), and Plasma (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AGXT2 Gene



SOURCE GeneReport for Unigene cluster for AGXT2 Gene Hs.34494

genes like me logo Genes that share expression patterns with AGXT2: view

Protein tissue co-expression partners for AGXT2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AGXT2 Gene

Orthologs for AGXT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AGXT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AGXT2 35
  • 86.64 (n)
  • 86.19 (a)
AGXT2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGXT2 35
  • 86.29 (n)
  • 84.8 (a)
AGXT2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agxt2 35
  • 84.47 (n)
  • 84.99 (a)
Agxt2 16
Agxt2 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AGXT2 35
  • 99.42 (n)
  • 99.22 (a)
AGXT2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agxt2 35
  • 83.98 (n)
  • 83.4 (a)
oppossum
(Monodelphis domestica)
Mammalia AGXT2 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
chicken
(Gallus gallus)
Aves AGXT2 35
  • 71.4 (n)
  • 69.94 (a)
AGXT2 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGXT2 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agxt2 35
  • 65.41 (n)
  • 65.69 (a)
zebrafish
(Danio rerio)
Actinopterygii agxt2 35
  • 60.53 (n)
  • 57.82 (a)
agxt2 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11241 37
  • 56 (a)
CG11241 35
  • 56.56 (n)
  • 55.7 (a)
CG11241 36
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012404 35
  • 56.43 (n)
  • 54.8 (a)
worm
(Caenorhabditis elegans)
Secernentea T09B4.8 37
  • 53 (a)
T09B4.8 35
  • 57.29 (n)
  • 54.14 (a)
T09B4.8 36
  • 52 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARG8 36
  • 27 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AGT2 35
  • 54.39 (n)
  • 48.28 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3270 35
rice
(Oryza sativa)
Liliopsida Os03g0171900 35
  • 52.97 (n)
  • 46.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for AGXT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGXT2 Gene

ENSEMBL:
Gene Tree for AGXT2 (if available)
TreeFam:
Gene Tree for AGXT2 (if available)

Paralogs for AGXT2 Gene

Paralogs for AGXT2 Gene

(2) SIMAP similar genes for AGXT2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with AGXT2: view

Variants for AGXT2 Gene

Sequence variations from dbSNP and Humsavar for AGXT2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs37369 - 35,037,010(+) GAAGA(C/T)GGTGC reference, missense
rs180749 - 35,033,500(+) TGTAG(A/G)TCCCT reference, missense
rs37370 -, -, - 35,039,381(+) ATCTG(A/C/G/T)TTCCT reference, missense
rs16899974 - 34,998,772(+) TTCTA(A/C)TGCAA intron-variant, reference, missense
rs16870794 - 35,037,034(+) GCGGC(C/G/T)GAGCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for AGXT2 Gene

Variant ID Type Subtype PubMed ID
nsv881607 CNV Loss 21882294
dgv6032n71 CNV Gain 21882294

Variation tolerance for AGXT2 Gene

Residual Variation Intolerance Score: 74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.77; 91.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGXT2 Gene

HapMap Linkage Disequilibrium report
AGXT2
Human Gene Mutation Database (HGMD)
AGXT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGXT2 Gene

Disorders for AGXT2 Gene

Relevant External Links for AGXT2

Genetic Association Database (GAD)
AGXT2
Human Genome Epidemiology (HuGE) Navigator
AGXT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGXT2

No disorders were found for AGXT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGXT2 Gene

Publications for AGXT2 Gene

  1. Glycolate and glyoxylate metabolism in HepG2 cells. (PMID: 15240345) Baker P.R. … Holmes R.P. (Am. J. Physiol., Cell Physiol. 2004) 2 3 23 25 26
  2. Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production. (PMID: 20018850) Rodionov R.N. … Lentz S.R. (J. Biol. Chem. 2010) 3 4 23 67
  3. Molecular cloning and sequencing of a cDNA encoding alanine- glyoxylate aminotransferase 2 from rat kidney. (PMID: 7592550) Matsui-Lee I.S. … Kido R. (J. Biochem. 1995) 3 23 25
  4. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  5. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26

Products for AGXT2 Gene

Sources for AGXT2 Gene

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