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Aliases for AGTRAP Gene

Aliases for AGTRAP Gene

  • Angiotensin II Receptor Associated Protein 2 3 5
  • AT1 Receptor-Associated Protein 3 4
  • ATRAP 3 4
  • Angiotensin II, Type I Receptor-Associated Protein 3
  • Type-1 Angiotensin II Receptor-Associated Protein 3
  • ATI Receptor-Associated Protein 3

External Ids for AGTRAP Gene

Previous GeneCards Identifiers for AGTRAP Gene

  • GC00U990804
  • GC01P011639
  • GC01P011405
  • GC01P011505
  • GC01P011730
  • GC01P011796
  • GC01P010950

Summaries for AGTRAP Gene

Entrez Gene Summary for AGTRAP Gene

  • This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGTRAP Gene

AGTRAP (Angiotensin II Receptor Associated Protein) is a Protein Coding gene. Among its related pathways are HIV Life Cycle. GO annotations related to this gene include angiotensin type II receptor activity.

UniProtKB/Swiss-Prot for AGTRAP Gene

  • Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

Gene Wiki entry for AGTRAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGTRAP Gene

Genomics for AGTRAP Gene

Regulatory Elements for AGTRAP Gene

Enhancers for AGTRAP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F011735 1 FANTOM5 ENCODE 20.9 +1.4 1413 3.4 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 AGTRAP TNFRSF1B MAD2L2 DRAXIN EXOSC10 C1orf127 MTHFR CLCN6 TNFRSF8 FBXO6
GH01F011739 0.6 ENCODE 15.9 +5.3 5311 1.7 HDGF ATF1 ELK1 GATA2 FOS NCOA1 CREB3 MEF2D SMARCA4 MYNN AGTRAP GC01P011758
GH01F011747 0.2 ENCODE 14.6 +11.4 11385 0.2 SMARCE1 HINFP DPF2 CREB3 POLR2A SMARCA4 IKZF1 MYC AGTRAP GC01P011758
GH01F011749 0.8 ENCODE 14.4 +13.8 13781 0.4 HDGF HDAC1 ATF1 PKNOX1 ARNT TBL1XR1 KLF17 ARID4B RAD21 KLF7 AGTRAP GC01P011758
GH01F011728 1.3 Ensembl ENCODE 14.1 -4.4 -4374 5.8 HDGF ATF1 PKNOX1 ZFP64 GLI4 YY1 GLIS2 FOS ZNF263 CREB3 AGTRAP UBE2V2P3 GC01P011722
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around AGTRAP on UCSC Golden Path with GeneCards custom track

Promoters for AGTRAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000279215 1026 1401 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for AGTRAP Gene

Chromosome:
1
Start:
11,735,474 bp from pter
End:
11,754,802 bp from pter
Size:
19,329 bases
Orientation:
Plus strand

Genomic View for AGTRAP Gene

Genes around AGTRAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGTRAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGTRAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGTRAP Gene

Proteins for AGTRAP Gene

  • Protein details for AGTRAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6RW13-ATRAP_HUMAN
    Recommended name:
    Type-1 angiotensin II receptor-associated protein
    Protein Accession:
    Q6RW13
    Secondary Accessions:
    • A8MVQ5
    • Q5SNV4
    • Q5SNV5
    • Q96AC0
    • Q96PL4
    • Q9NRW9

    Protein attributes for AGTRAP Gene

    Size:
    159 amino acids
    Molecular mass:
    17419 Da
    Quaternary structure:
    • Interacts with RACK1, and with the C-terminal region of AGTR1.
    SequenceCaution:
    • Sequence=CAI15876.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for AGTRAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGTRAP Gene

Post-translational modifications for AGTRAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for AGTRAP

No data available for DME Specific Peptides for AGTRAP Gene

Domains & Families for AGTRAP Gene

Protein Domains for AGTRAP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AGTRAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AGTRAP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for AGTRAP Gene

Function for AGTRAP Gene

Molecular function for AGTRAP Gene

UniProtKB/Swiss-Prot Function:
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

Gene Ontology (GO) - Molecular Function for AGTRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004945 angiotensin type II receptor activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with AGTRAP: view
genes like me logo Genes that share phenotypes with AGTRAP: view

Animal Model Products

miRNA for AGTRAP Gene

miRTarBase miRNAs that target AGTRAP

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGTRAP Gene

Localization for AGTRAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGTRAP Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGTRAP Gene COMPARTMENTS Subcellular localization image for AGTRAP gene
Compartment Confidence
nucleus 5
plasma membrane 4
endoplasmic reticulum 3
golgi apparatus 3
cytosol 2
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for AGTRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with AGTRAP: view

Pathways & Interactions for AGTRAP Gene

SuperPathways for AGTRAP Gene

SuperPathway Contained pathways
1 HIV Life Cycle
.45
genes like me logo Genes that share pathways with AGTRAP: view

Pathways by source for AGTRAP Gene

2 Reactome pathways for AGTRAP Gene

Gene Ontology (GO) - Biological Process for AGTRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0008217 regulation of blood pressure IEA --
GO:0038166 angiotensin-activated signaling pathway IEA --
genes like me logo Genes that share ontologies with AGTRAP: view

No data available for SIGNOR curated interactions for AGTRAP Gene

Drugs & Compounds for AGTRAP Gene

(14) Drugs for AGTRAP Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azilsartan medoxomil Approved Pharma Angiotensin II receptor type 1 antagonist 0
Irbesartan Approved, Investigational Pharma Antagonist Angiotensin II inhibitor 101
Tranilast Approved, Investigational Pharma Angiogenesis inhibitor 7
Angiotensin (1-7) Pharma Vasoconstriction peptide hormone 0
Angiotensin 1/2 (1-5) Pharma Vasoconstrictor 0

(13) ApexBio Compounds for AGTRAP Gene

Compound Action Cas Number
Angiotensin (1-7) Vasoconstriction peptide hormone 51833-78-4
Angiotensin 1/2 (1-5) Vasoconstrictor 58442-64-1
Angiotensin 1/2 (1-6) Vasoconstrictor 47896-63-9
Angiotensin 1/2 + A (2 - 8) 51833-76-2
Angiotensin III (human, mouse) Aldosterone stimulator 13602-53-4
AVE 0991 Agonist of angiotensin-(1-7) receptor 304462-19-9
AVE 0991 sodium salt Ang-(1-7) receptor Mas agonist 306288-04-0
Azilsartan 147403-03-0
Azilsartan Medoxomil Angiotensin II receptor type 1 antagonist 863031-21-4
Eprosartan Mesylate 144143-96-4
Irbesartan Angiotensin II inhibitor 138402-11-6
PD123319 Angiotensin AT2 receptor antagonist 130663-39-7
Tranilast Angiogenesis inhibitor 53902-12-8
genes like me logo Genes that share compounds with AGTRAP: view

Transcripts for AGTRAP Gene

Unigene Clusters for AGTRAP Gene

Angiotensin II receptor-associated protein:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGTRAP Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h
SP1: -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: -
SP7: - - - - - -
SP8:
SP9: - - - - - -

Relevant External Links for AGTRAP Gene

GeneLoc Exon Structure for
AGTRAP
ECgene alternative splicing isoforms for
AGTRAP

Expression for AGTRAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AGTRAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGTRAP Gene

This gene is overexpressed in Whole Blood (x17.8).

Protein differential expression in normal tissues from HIPED for AGTRAP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.9), Monocytes (11.9), NK cells (7.2), and Gallbladder (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AGTRAP Gene



Protein tissue co-expression partners for AGTRAP Gene

NURSA nuclear receptor signaling pathways regulating expression of AGTRAP Gene:

AGTRAP

SOURCE GeneReport for Unigene cluster for AGTRAP Gene:

Hs.464438

mRNA Expression by UniProt/SwissProt for AGTRAP Gene:

Q6RW13-ATRAP_HUMAN
Tissue specificity: Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.
genes like me logo Genes that share expression patterns with AGTRAP: view

Primer Products

Orthologs for AGTRAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGTRAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGTRAP 34
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia AGTRAP 35 34
  • 83.22 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AGTRAP 34 35
  • 82.21 (n)
mouse
(Mus musculus)
Mammalia Agtrap 34 16 35
  • 81.97 (n)
rat
(Rattus norvegicus)
Mammalia Agtrap 34
  • 81.97 (n)
oppossum
(Monodelphis domestica)
Mammalia AGTRAP 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 47 (a)
OneToMany
-- 35
  • 47 (a)
OneToMany
chicken
(Gallus gallus)
Aves AGTRAP 34 35
  • 66.67 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia agtrap 34
  • 60.42 (n)
zebrafish
(Danio rerio)
Actinopterygii agtrap 34 35
  • 61.22 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10899 34
Species where no ortholog for AGTRAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGTRAP Gene

ENSEMBL:
Gene Tree for AGTRAP (if available)
TreeFam:
Gene Tree for AGTRAP (if available)

Paralogs for AGTRAP Gene

No data available for Paralogs for AGTRAP Gene

Variants for AGTRAP Gene

Sequence variations from dbSNP and Humsavar for AGTRAP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10864533 -- 11,749,678(+) GGCTG(A/T)TGTCC intron-variant
rs11121814 -- 11,737,769(+) GACAG(G/T)CTAAG intron-variant
rs11121815 -- 11,739,991(+) CTTGG(C/T)CCATT intron-variant
rs11121816 -- 11,740,421(+) GCAAC(G/T)GGTGC intron-variant
rs11121817 -- 11,741,030(+) GAATC(A/G)TCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGTRAP Gene

Variant ID Type Subtype PubMed ID
dgv108n54 CNV loss 21841781
nsv508880 CNV insertion 20534489
nsv545418 CNV loss 21841781
nsv545419 CNV gain 21841781
nsv545420 CNV loss 21841781
nsv545421 CNV loss 21841781
nsv832758 CNV loss 17160897

Variation tolerance for AGTRAP Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 9.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGTRAP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGTRAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGTRAP Gene

Disorders for AGTRAP Gene

Relevant External Links for AGTRAP

Genetic Association Database (GAD)
AGTRAP
Human Genome Epidemiology (HuGE) Navigator
AGTRAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGTRAP

No disorders were found for AGTRAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGTRAP Gene

Publications for AGTRAP Gene

  1. Identification and characterization of AGTRAP, a human homolog of murine angiotensin II receptor-associated protein (Agtrap). (PMID: 11733189) Wang W. … Mao Y. (Int. J. Biochem. Cell Biol. 2002) 2 3 4 22 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C. … Munroe P.B. (Nat. Genet. 2009) 3 46 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for AGTRAP Gene

Sources for AGTRAP Gene

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