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Aliases for AGTRAP Gene

Aliases for AGTRAP Gene

  • Angiotensin II Receptor-Associated Protein 2 3
  • AT1 Receptor-Associated Protein 3 4
  • ATRAP 3 4
  • Angiotensin II, Type I Receptor-Associated Protein 3
  • Type-1 Angiotensin II Receptor-Associated Protein 3
  • ATI Receptor-Associated Protein 3

External Ids for AGTRAP Gene

Summaries for AGTRAP Gene

Entrez Gene Summary for AGTRAP Gene

  • This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGTRAP Gene

AGTRAP (Angiotensin II Receptor-Associated Protein) is a Protein Coding gene. GO annotations related to this gene include angiotensin type II receptor activity.

UniProtKB/Swiss-Prot for AGTRAP Gene

  • Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

Gene Wiki entry for AGTRAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGTRAP Gene

Genomics for AGTRAP Gene

Genomic Location for AGTRAP Gene

Start:
11,736,084 bp from pter
End:
11,754,802 bp from pter
Size:
18,719 bases
Orientation:
Plus strand

Genomic View for AGTRAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGTRAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGTRAP Gene

Regulatory Elements for AGTRAP Gene

Proteins for AGTRAP Gene

  • Protein details for AGTRAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6RW13-ATRAP_HUMAN
    Recommended name:
    Type-1 angiotensin II receptor-associated protein
    Protein Accession:
    Q6RW13
    Secondary Accessions:
    • A8MVQ5
    • Q5SNV4
    • Q5SNV5
    • Q96AC0
    • Q96PL4
    • Q9NRW9

    Protein attributes for AGTRAP Gene

    Size:
    159 amino acids
    Molecular mass:
    17419 Da
    Quaternary structure:
    • Interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1.
    SequenceCaution:
    • Sequence=CAI15876.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for AGTRAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGTRAP Gene

Proteomics data for AGTRAP Gene at MOPED

Post-translational modifications for AGTRAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AGTRAP Gene

Domains for AGTRAP Gene

Protein Domains for AGTRAP Gene

genes like me logo Genes that share domains with AGTRAP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for AGTRAP Gene

Function for AGTRAP Gene

Molecular function for AGTRAP Gene

UniProtKB/Swiss-Prot Function: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

Gene Ontology (GO) - Molecular Function for AGTRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004945 angiotensin type II receptor activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with AGTRAP: view

Phenotypes for AGTRAP Gene

genes like me logo Genes that share phenotypes with AGTRAP: view

miRNA for AGTRAP Gene

miRTarBase miRNAs that target AGTRAP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for AGTRAP Gene

Localization for AGTRAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGTRAP Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGTRAP Gene COMPARTMENTS Subcellular localization image for AGTRAP gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 3
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for AGTRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with AGTRAP: view

Pathways for AGTRAP Gene

SuperPathways for AGTRAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for AGTRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0008217 regulation of blood pressure IEA --
GO:0038166 angiotensin-activated signaling pathway IEA --
genes like me logo Genes that share ontologies with AGTRAP: view

No data available for Pathways by source for AGTRAP Gene

Compounds for AGTRAP Gene

(1) HMDB Compounds for AGTRAP Gene

Compound Synonyms Cas Number PubMed IDs
Angiotensin II
  • Hypertensin
11128-99-7
genes like me logo Genes that share compounds with AGTRAP: view

Transcripts for AGTRAP Gene

Unigene Clusters for AGTRAP Gene

Angiotensin II receptor-associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGTRAP Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h
SP1: -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: -
SP7: - - - - - -
SP8:
SP9: - - - - - -

Relevant External Links for AGTRAP Gene

GeneLoc Exon Structure for
AGTRAP
ECgene alternative splicing isoforms for
AGTRAP

Expression for AGTRAP Gene

mRNA expression in normal human tissues for AGTRAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGTRAP Gene

This gene is overexpressed in Whole Blood (17.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGTRAP Gene

SOURCE GeneReport for Unigene cluster for AGTRAP Gene Hs.464438

mRNA Expression by UniProt/SwissProt for AGTRAP Gene

Q6RW13-ATRAP_HUMAN
Tissue specificity: Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.
genes like me logo Genes that share expressions with AGTRAP: view

Orthologs for AGTRAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGTRAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGTRAP 36
  • 99.79 (n)
  • 99.37 (a)
cow
(Bos Taurus)
Mammalia AGTRAP 36
  • 82.21 (n)
  • 75.68 (a)
AGTRAP 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGTRAP 36
  • 83.22 (n)
  • 75.5 (a)
AGTRAP 37
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agtrap 36
  • 81.97 (n)
  • 77.36 (a)
Agtrap 16
Agtrap 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGTRAP 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 47 (a)
OneToMany
-- 37
  • 47 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Agtrap 36
  • 81.97 (n)
  • 75.47 (a)
chicken
(Gallus gallus)
Aves AGTRAP 36
  • 66.67 (n)
  • 64.54 (a)
AGTRAP 37
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agtrap 36
  • 60.42 (n)
  • 59.72 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10899 36
zebrafish
(Danio rerio)
Actinopterygii agtrap 36
  • 61.22 (n)
  • 56.6 (a)
agtrap 37
  • 52 (a)
OneToOne
Species with no ortholog for AGTRAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGTRAP Gene

ENSEMBL:
Gene Tree for AGTRAP (if available)
TreeFam:
Gene Tree for AGTRAP (if available)

Paralogs for AGTRAP Gene

No data available for Paralogs for AGTRAP Gene

Variants for AGTRAP Gene

Sequence variations from dbSNP and Humsavar for AGTRAP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8617 -- 11,750,448(-) TAGGA(A/G)GTAAA utr-variant-3-prime
rs12955 -- 11,750,435(-) GAGAC(A/C)CTGGT utr-variant-3-prime
rs14962 -- 11,750,574(-) CAGGG(A/C)TTCCA utr-variant-3-prime
rs1128055 -- 11,750,614(+) GCAGT(C/T)TGGCA utr-variant-3-prime
rs1128059 -- 11,750,617(+) GTCTG(A/G)CATGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for AGTRAP Gene

Variant ID Type Subtype PubMed ID
nsv832758 CNV Loss 17160897
nsv871014 CNV Gain 21882294
dgv140n71 CNV Loss 21882294
nsv508880 CNV Insertion 20534489
nsv871919 CNV Loss 21882294
nsv870510 CNV Gain 21882294
nsv871561 CNV Gain 21882294

Relevant External Links for AGTRAP Gene

HapMap Linkage Disequilibrium report
AGTRAP

Disorders for AGTRAP Gene

Relevant External Links for AGTRAP

Genetic Association Database (GAD)
AGTRAP
Human Genome Epidemiology (HuGE) Navigator
AGTRAP
genes like me logo Genes that share disorders with AGTRAP: view

No data available for UniProtKB/Swiss-Prot for AGTRAP Gene

Publications for AGTRAP Gene

  1. Identification and characterization of AGTRAP, a human homolog of murine angiotensin II receptor-associated protein (Agtrap). (PMID: 11733189) Wang W. … Mao Y. (Int. J. Biochem. Cell Biol. 2002) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling. (PMID: 12960423) Lopez-Ilasaca M. … Dzau V.J. (Mol. Biol. Cell 2003) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C. … Munroe P.B. (Nat. Genet. 2009) 3 49

Products for AGTRAP Gene

Sources for AGTRAP Gene

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