Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AGTRAP Gene

protein-coding   GIFtS: 49
GCID: GC01P011796

angiotensin II receptor-associated protein

 Explore 3 diseases affiliated with
AGTRAP via our new
 Human Malady Compendium 
Biological research products
for AGTRAP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Angiotensin II Receptor-Associated Protein1 2
ATRAP1 2 3
AT1 Receptor-Associated Protein2 3
Angiotensin II, Type I Receptor-Associated Protein2
ATI Receptor-Associated Protein2
Type-1 Angiotensin II Receptor-Associated Protein2

External Ids:    HGNC: 135391   Entrez Gene: 570852   Ensembl: ENSG000001776747   OMIM: 6087295   UniProtKB: Q6RW133   

Export aliases for AGTRAP gene to outside databases

Previous GC identifers: GC00U990804 GC01P011639 GC01P011405 GC01P011505 GC01P011730 GC01P010950


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AGTRAP:
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The
gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling.
Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ATRAP_HUMAN, Q6RW13
Function: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating
receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a
decrease in cell proliferation and angiotensin II-stimulated transcriptional activity

Gene Wiki entry for AGTRAP


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AGTRAP gene promoter:
         USF1   NF-kappaB   Tal-1beta   SRY   USF-1   NF-kappaB2   FOXJ2 (long isoform)   FOXJ2   ITF-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAGTRAP promoter sequence
   Search SABiosciences Chromatin IP Primers for AGTRAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGTRAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

AGTRAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGTRAP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P011796:  view genomic region     (about GC identifiers)

Start:
11,796,141 bp from pter      End:
11,814,859 bp from pter
Size:
18,719 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ATRAP_HUMAN, Q6RW13 (See protein sequence)
Recommended Name: Type-1 angiotensin II receptor-associated protein  
Size: 159 amino acids; 17419 Da
Subunit: Interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass
membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular
membranes, Endoplasmic reticulum, Golgi and endocytic vesicles
Sequence caution: Sequence=CAI15876.1; Type=Erroneous gene model prediction;
Secondary accessions: A8MVQ5 Q5SNV4 Q5SNV5 Q96AC0 Q96PL4 Q9NRW9
Alternative splicing: 5 isoforms:  Q6RW13-1   Q6RW13-2   Q6RW13-3   Q6RW13-5   Q6RW13-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AGTRAP: NX_Q6RW13

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6RW13

  • AGTRAP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001035284.1  NP_001035285.1  NP_001035286.1  NP_001035287.1  NP_065083.3  

    ENSEMBL proteins: 
     ENSP00000365824   ENSP00000424455   ENSP00000383688   ENSP00000365816   ENSP00000365814  
     ENSP00000319713   ENSP00000408505   ENSP00000422647  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): AGTRAP
    OriGene Custom Protein Services for AGTRAP 
    GenScript Custom Purified and Recombinant Proteins Services for AGTRAP
    Novus Biologicals AGTRAP Proteins
    Novus Biologicals AGTRAP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for AGTRAP

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane IEA--
    GO:0005938cell cortex IEA--
    GO:0016021integral to membrane IEA--


    AGTRAP for ontologies           About GeneDecksing



    AGTRAP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for AGTRAP 
    GenScript Custom Superior Antibodies Services for AGTRAP
    Novus Biologicals AGTRAP Antibodies
    Search for Antibodies for AGTRAP at Abcam  
    Uscn Antibodies for AGTRAP
    Search ThermoFisher Antibodies for AGTRAP

    Assay Products for AGTRAP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AGTRAP
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for AGTRAP


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    AGTRAP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009436 Angiotensin_II_typ1_rcpt-assoc

    Graphical View of Domain Structure for InterPro Entry Q6RW13

    ProtoNet protein and cluster: Q6RW13


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ATRAP_HUMAN, Q6RW13
    Function: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating
    receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a
    decrease in cell proliferation and angiotensin II-stimulated transcriptional activity

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 5): AGTRAP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AGTRAP
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate AGTRAP:
    hsa-miR-34b* hsa-miR-34a hsa-miR-34c-5p hsa-miR-449b hsa-miR-155 hsa-miR-449a hsa-miR-449c
    SwitchGear 3'UTR luciferase reporter plasmidAGTRAP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AGTRAP (see all 7)
    OriGene shRNA RFP: AGTRAP
    OriGene siRNA: AGTRAP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGTRAP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AGTRAP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGTRAP (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGTRAP (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): AGTRAP (NM_001040195)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGTRAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGTRAP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AGTRAP
    Search LifeMap BioReagents cell lines for AGTRAP

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGTRAP

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004945angiotensin type II receptor activity IEA--
    GO:0005515protein binding IPI19060904


    AGTRAP for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for AGTRAP:
     Increased HPV18 LCR reporter a 

    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Agtrap):
     cardiovascular system  homeostasis/metabolism  renal/urinary system 

    AGTRAP for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AGTRAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/20 Interacting proteins for AGTRAP (Q6RW131, 3 ENSP000003197134) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PITPNC1Q9UKF71, 3, ENSP000003356184EBI-741181,EBI-749241 I2D: score=4 STRING: ENSP00000335618
    AGTR1P305563, ENSP000002734304I2D: score=4 STRING: ENSP00000273430
    GNB2L1P632443, ENSP000003660134I2D: score=2 STRING: ENSP00000366013
    AGTR2P500523, ENSP000003609734I2D: score=1 STRING: ENSP00000360973
    TNFRSF1AP194383, ENSP000001627494I2D: score=1 STRING: ENSP00000162749
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0008217regulation of blood pressure IEA--


    AGTRAP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AGTRAP

    1 HMDB Compound for AGTRAP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Angiotensin IIHypertensin (see all 11)11128-99-7--
    Search CenterWatch for drugs/clinical trials and news about AGTRAP / ATRAP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AGTRAP gene (5 alternative transcripts): 
    NM_001040194.1  NM_001040195.1  NM_001040196.1  NM_001040197.1  NM_020350.4  

    Unigene Cluster for AGTRAP:

    Angiotensin II receptor-associated protein
    Hs.464438  [show with all ESTs]
    Unigene Representative Sequence: BQ422937
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376637(uc001asx.3) ENST00000476512 ENST00000400895 ENST00000494437
    ENST00000491346 ENST00000376629(uc001asu.3 uc001asw.3) ENST00000376627
    ENST00000314340(uc001ast.3 uc001asv.3) ENST00000452018 ENST00000510878
    ENST00000476309 ENST00000514733 ENST00000513739 ENST00000471765

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 5): AGTRAP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AGTRAP
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate AGTRAP:
    hsa-miR-34b* hsa-miR-34a hsa-miR-34c-5p hsa-miR-449b hsa-miR-155 hsa-miR-449a hsa-miR-449c
    SwitchGear 3'UTR luciferase reporter plasmidAGTRAP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AGTRAP (see all 7)
    OriGene shRNA RFP: AGTRAP
    OriGene siRNA: AGTRAP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGTRAP
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGTRAP (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGTRAP (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): AGTRAP (NM_001040195)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGTRAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGTRAP 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AGTRAP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AGTRAP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGTRAP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGTRAP

    Additional cDNA sequence: 

    AF165187.1 AF312374.1 AK290042.1 BC011946.1 BC017328.2 

    11 DOTS entries:

    DT.100818356  DT.100803123  DT.100818354  DT.316362  DT.316363  DT.100818355  DT.456383  DT.95311390 
    DT.95311389  DT.97845550  DT.97845551 

    24/246 AceView cDNA sequences (see all 246):

    CB160239 BM018174 BM709267 BG178862 CF126481 CD671940 BQ433300 BM555907 
    CA489003 BX644855 BE048164 BM910550 BM006372 BM793897 BG679718 F12021 
    AL519725 BM824447 BP355708 BI906864 BG696245 BF726967 BG746357 CA488206 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for AGTRAP (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h
    SP1:              -                                                                                             
    SP2:              -     -     -                             -                                                   
    SP3:              -     -     -                                                                                 
    SP4:              -     -     -     -                       -                                                   
    SP5:              -     -     -     -                                                                           


    ECgene alternative splicing isoforms for AGTRAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AGTRAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGCCTAGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    AGTRAP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisTestis InterstitiumTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See AGTRAP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AGTRAP

    SOURCE GeneReport for Unigene cluster: Hs.464438

    UniProtKB/Swiss-Prot: ATRAP_HUMAN, Q6RW13
    Tissue specificity: Ubiquitous but more abundant in kidney, heart, pancreas and thyroid

        SABiosciences Expression via Pathway-Focused PCR Array including AGTRAP: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AGTRAP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AGTRAP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGTRAP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGTRAP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGTRAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for AGTRAP gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agtrap1 , 5 angiotensin II, type I receptor-associated protein1, 5 81.97(n)1
    77.36(a)1
      4 (78.67 cM)5
    116101  NM_009642.41  NP_033772.21 
     1480770615 
    chicken
    (Gallus gallus)
    Aves AGTRAP1 angiotensin II receptor-associated protein 66.67(n)
    64.54(a)
      419491  XM_417646.3  XP_417646.2 
    zebrafish
    (Danio rerio)
    Actinopterygii agtrap1 angiotensin II receptor-associated protein 61.01(n)
    56.6(a)
      793937  NM_001201345.1  NP_001188274.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG326386
    --
    26(a)
    1 ↔ 1
    X(13016909-13022827)


    ENSEMBL Gene Tree for AGTRAP (if available)
    TreeFam Gene Tree for AGTRAP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/318 NCBI SNPs in AGTRAP are shown (see all 318    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs767459951,2
    C,--11794145(+) GCAGAA/G/TCACCT 5 -- us2k10--------
    rs774271041,2
    C--11794146(+) CAGATC/GACCTG 5 -- us2k10--------
    rs178759011,2
    C,F,--11794154(+) CTGAGG/ATCAGG 5 -- us2k1 tfbs33Minor allele frequency- A:0.02NS WA 96
    rs1381825021,2
    --11794223(+) TCAGCC/TGGGCA 5 -- us2k10--------
    rs1818450081,2
    --11794328(+) CGCCAC/TTGCAC 5 -- us2k10--------
    rs347781501,2
    C--11794367(+) ATCTC-/AAAAAA 5 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1428729131,2
    --11794426(+) AAATTA/GCTCTC 5 -- us2k10--------
    rs768172121,2
    C--11794449(+) TACTAA/GTAACA 5 -- us2k10--------
    rs121215771,2
    C,F,--11794553(+) CTAGAC/GTGGGG 5 -- us2k114Minor allele frequency- G:0.21NA NS WA EA 2040
    rs1869082081,2
    --11794667(+) AGACTA/GTGGGT 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for AGTRAP (11796141 - 11814859 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for AGTRAP: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AGTRAP
    DNA2.0 Custom Variant and Variant Library Synthesis for AGTRAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    AGTRAP for disorders           About GeneDecksing

    OMIM gene information: 608729    OMIM disorders: --

    3 diseases for AGTRAP:    About MalaCards
    hypoxia    thyroiditis    septic shock

    Human Genome Epidemiology (HuGE) Navigator: AGTRAP (5 documents)

    Export disorders for AGTRAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AGTRAP gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with AGTRAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of AGTRAP, a human homolog of murine angiotensin II receptor-associated protein (Agtrap). (PubMed id 11733189)1, 2, 3, 9 Wang W.... Mao Y. (2002)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling. (PubMed id 12960423)1, 2 Lopez-Ilasaca M.... Dzau V.J. (2003)
    5. ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth. (PubMed id 11162453)1, 9 Cui T....Horiuchi M. (2000)
    6. The phosphatidylinositol transfer protein RdgBI^ binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain inter acts with the integral membrane protein ATRAP (angiotensin II type I receptor-a ssociated protein). (PubMed id 21728994)1 Garner K....Cockcroft S. (2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Association of angiotensin II type 1 receptor-associa ted protein gene polymorphism with increased mortality in septic shock. (PubMed id 21423001)1 Nakada T.A....Walley K.R. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. CSF angiotensin II and angiotensin-converting enzyme levels in anti-aquaporin-4 autoimmunity. (PubMed id 20541774)1 Matsushita T....Kira J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57085 HGNC: 13539 AceView: AGTRAP Ensembl:ENSG00000177674 euGenes: HUgn57085
    ECgene: AGTRAP H-InvDB: AGTRAP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AGTRAP Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/agtrap/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AGTRAP gene:
    Search GeneIP for patents involving AGTRAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for AGTRAP  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AGTRAP   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AGTRAP  
     OriGene Protein Over-expression Lysate for AGTRAP   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for AGTRAP   OriGene 3'-UTR Clone for AGTRAP  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGTRAP   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGTRAP  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AGTRAP   OriGene Custom Protein Services for AGTRAP  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AGTRAP
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AGTRAP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGTRAP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGTRAP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGTRAP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGTRAP
     GenScript Custom Purified and Recombinant Proteins Services for AGTRAP GenScript cDNA clones with any tag delivered in your preferred vector for AGTRAP
     GenScript Custom Assay Services for AGTRAP GenScript Custom Superior Antibodies Services for AGTRAP
     GenScript Custom overexpressing Cell Line Services for AGTRAP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in AGTRAP promoter
     Search Chromatin IP Primers for AGTRAP
     RT2 qPCR Primer Assay in human, mouse, rat AGTRAP
     GNC Network for AGTRAP
     SABiosciences PCR Arrays including human, mouse, rat AGTRAP
     Search Tocris compounds for AGTRAP
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     AGTRAP antibodies
     AGTRAP proteins
     AGTRAP lysates
     Search for Antibodies for AGTRAP at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for AGTRAP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     AGTRAP Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for AGTRAP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGTRAP
     SwitchGear 3'UTR luciferase reporter plasmids for AGTRAP
     SwitchGear Promoter luciferase reporter plasmids for AGTRAP
     Search ThermoFisher Antibodies for AGTRAP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGTRAP
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AGTRAP gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4