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Aliases for AGTR2 Gene

Aliases for AGTR2 Gene

  • Angiotensin II Receptor, Type 2 2 3
  • Angiotensin II Type-2 Receptor 3 4
  • AT2 3 4
  • Type-2 Angiotensin II Receptor 3
  • Angiotensin Receptor 2 2
  • ATGR2 3
  • MRX88 3

External Ids for AGTR2 Gene

Summaries for AGTR2 Gene

Entrez Gene Summary for AGTR2 Gene

  • The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation. [provided by RefSeq, Jan 2010]

GeneCards Summary for AGTR2 Gene

AGTR2 (Angiotensin II Receptor, Type 2) is a Protein Coding gene. Diseases associated with AGTR2 include hypertrophic scars and posterior urethral valves. Among its related pathways are Signaling by GPCR and p70S6K Signaling. GO annotations related to this gene include transcription factor binding and receptor antagonist activity. An important paralog of this gene is ACKR3.

UniProtKB/Swiss-Prot for AGTR2 Gene

  • Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.

Tocris Summary for AGTR2 Gene

  • The angiotensin2 receptors (AT2) are a member of the angiotensin receptor group of G-protein-coupled receptors that also includes AT1 and AT4. They are located primarily in the brain, adrenal medulla, heart and uterus where they counterbalance the effects of the AT1 receptor. The human AT2 receptor gene has been localized to chromosome X (Xq22-q23).

Gene Wiki entry for AGTR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGTR2 Gene

Genomics for AGTR2 Gene

Genomic Location for AGTR2 Gene

Start:
116,170,705 bp from pter
End:
116,174,972 bp from pter
Size:
4,268 bases
Orientation:
Plus strand

Genomic View for AGTR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGTR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGTR2 Gene

Regulatory Elements for AGTR2 Gene

Proteins for AGTR2 Gene

  • Protein details for AGTR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50052-AGTR2_HUMAN
    Recommended name:
    Type-2 angiotensin II receptor
    Protein Accession:
    P50052
    Secondary Accessions:
    • B2R9V1
    • Q13016
    • Q6FGY7

    Protein attributes for AGTR2 Gene

    Size:
    363 amino acids
    Molecular mass:
    41184 Da
    Quaternary structure:
    • Interacts with MTUS1.

neXtProt entry for AGTR2 Gene

Proteomics data for AGTR2 Gene at MOPED

Post-translational modifications for AGTR2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn4, Asn13, Asn24, Asn29, and Asn34

Other Protein References for AGTR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for AGTR2 Gene

Domains for AGTR2 Gene

Gene Families for AGTR2 Gene

HGNC:
  • AGTR :GPCR / Class A : Angiotensin receptors
IUPHAR :

Suggested Antigen Peptide Sequences for AGTR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50052

UniProtKB/Swiss-Prot:

AGTR2_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P50052
genes like me logo Genes that share domains with AGTR2: view

Function for AGTR2 Gene

Molecular function for AGTR2 Gene

GENATLAS Biochemistry: angiotensin II (type-2) receptor,abundantly expressed during embryonic development in fetal tissues,in adrenal glands,heart and brain,G protein coupled receptor superfamily,involved in the activation of dephosphorylating enzymes,stimulating a phosphotyrosine phosphatase which inhibits guanylate cyclase (involved in blood pressure regulation)
UniProtKB/Swiss-Prot Function: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.

Gene Ontology (GO) - Molecular Function for AGTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004945 angiotensin type II receptor activity IPI 10406457
GO:0005515 protein binding IPI 10406457
GO:0008134 transcription factor binding IEA --
GO:0017046 peptide hormone binding IEA --
genes like me logo Genes that share ontologies with AGTR2: view
genes like me logo Genes that share phenotypes with AGTR2: view

Animal Models for AGTR2 Gene

MGI Knock Outs for AGTR2:

miRNA for AGTR2 Gene

miRTarBase miRNAs that target AGTR2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AGTR2 Gene

Localization for AGTR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGTR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGTR2 Gene COMPARTMENTS Subcellular localization image for AGTR2 gene
Compartment Confidence
plasma membrane 5
extracellular 4

Gene Ontology (GO) - Cellular Components for AGTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 17159079
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IC 10406457
GO:0016021 integral component of membrane --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with AGTR2: view

Pathways for AGTR2 Gene

genes like me logo Genes that share pathways with AGTR2: view

Gene Ontology (GO) - Biological Process for AGTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development --
GO:0001974 blood vessel remodeling TAS 17159080
GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin ISS --
GO:0002018 renin-angiotensin regulation of aldosterone production IEA --
GO:0002033 vasodilation by angiotensin involved in regulation of systemic arterial blood pressure IEA --
genes like me logo Genes that share ontologies with AGTR2: view

Compounds for AGTR2 Gene

(3) Tocris Compounds for AGTR2 Gene

Compound Action Cas Number
CGP 42112 Selective, high affinity AT2 ligand [127060-75-7]
Novokinin Orally active AT2 agonist [358738-77-9]
PD 123319 ditrifluoroacetate Potent, selective non-peptide AT2 antagonist [130663-39-7]

(1) HMDB Compounds for AGTR2 Gene

Compound Synonyms Cas Number PubMed IDs
Angiotensin II
  • Hypertensin
11128-99-7

(1) Drugbank Compounds for AGTR2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Tasosartan
145733-36-4 target antagonist

(6) IUPHAR Ligand for AGTR2 Gene

Ligand Type Action Affinity Pubmed IDs
[125I]CGP42112 Agonist Full agonist 10.6
angiotensin I Agonist Full agonist 10
CGP42112 Agonist Full agonist 9.63
angiotensin II Agonist Full agonist 9.3
PD123319 Antagonist Antagonist 9.2
angiotensin III Agonist Full agonist 8.5

(41) Novoseek inferred chemical compound relationships for AGTR2 Gene

Compound -log(P) Hits PubMed IDs
cgp42112a 92.7 12
pd123319 92.2 24
losartan 83.8 42
ang ii 81.4 24
etoperidone 71.4 2
genes like me logo Genes that share compounds with AGTR2: view

Transcripts for AGTR2 Gene

mRNA/cDNA for AGTR2 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AGTR2 Gene

Angiotensin II receptor, type 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGTR2 Gene

No ASD Table

Relevant External Links for AGTR2 Gene

GeneLoc Exon Structure for
AGTR2
ECgene alternative splicing isoforms for
AGTR2

Expression for AGTR2 Gene

mRNA expression in normal human tissues for AGTR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGTR2 Gene

This gene is overexpressed in Lung (22.1), Fallopian Tube (8.4), and Uterus (4.3).

SOURCE GeneReport for Unigene cluster for AGTR2 Gene Hs.405348

mRNA Expression by UniProt/SwissProt for AGTR2 Gene

P50052-AGTR2_HUMAN
Tissue specificity: In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine.
genes like me logo Genes that share expressions with AGTR2: view

No data available for Protein expression for AGTR2 Gene

Orthologs for AGTR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGTR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGTR2 35
  • 99.72 (n)
  • 99.72 (a)
AGTR2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AGTR2 35
  • 91.9 (n)
  • 94.2 (a)
AT2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGTR2 35
  • 92.63 (n)
  • 95.86 (a)
AGTR2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agtr2 35
  • 89.16 (n)
  • 91.74 (a)
Agtr2 16
Agtr2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGTR2 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agtr2 35
  • 89.35 (n)
  • 92.29 (a)
chicken
(Gallus gallus)
Aves AGTR2 35
  • 62.62 (n)
  • 53.04 (a)
AGTR2 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGTR2 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agtr2 35
  • 58.53 (n)
  • 50.3 (a)
zebrafish
(Danio rerio)
Actinopterygii agtr2 35
  • 53.41 (n)
  • 46.49 (a)
agtr2 36
  • 43 (a)
OneToOne
Species with no ortholog for AGTR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGTR2 Gene

ENSEMBL:
Gene Tree for AGTR2 (if available)
TreeFam:
Gene Tree for AGTR2 (if available)

Paralogs for AGTR2 Gene

Paralogs for AGTR2 Gene

genes like me logo Genes that share paralogs with AGTR2: view

Variants for AGTR2 Gene

Sequence variations from dbSNP and Humsavar for AGTR2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs5190 -- 116,172,778(+) CCCCT(C/T)GTTTG synonymous-codon, reference
rs5191 Benign, - 116,173,023(+) GAACA(A/G)GATAA missense, reference
rs5192 -- 116,173,060(+) GCTGC(C/T)GTTGT synonymous-codon, reference
rs5193 -- 116,173,571(+) AGATT(G/T)TCATT utr-variant-3-prime
rs5194 -- 116,173,577(+) TCATT(A/G)GTGAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for AGTR2 Gene

Variant ID Type Subtype PubMed ID
dgv2466e1 CNV Complex 17122850
nsv9965 CNV Gain 18304495

Relevant External Links for AGTR2 Gene

HapMap Linkage Disequilibrium report
AGTR2
Human Gene Mutation Database (HGMD)
AGTR2
Locus Specific Mutation Databases (LSDB)
AGTR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGTR2 Gene

Disorders for AGTR2 Gene

(54) Novoseek inferred disease relationships for AGTR2 Gene

Disease -log(P) Hits PubMed IDs
diabetic nephropathies 52.2 3
cardiac hypertrophy 51.5 1
ventricular hypertrophy 49.4 7
renal disease 48.5 11
hypertrophy 46.1 3

Relevant External Links for AGTR2

Genetic Association Database (GAD)
AGTR2
Human Genome Epidemiology (HuGE) Navigator
AGTR2
genes like me logo Genes that share disorders with AGTR2: view

No data available for UniProtKB/Swiss-Prot for AGTR2 Gene

Publications for AGTR2 Gene

  1. Molecular cloning of the human angiotensin II type 2 receptor cDNA. (PMID: 7999093) Martin M.M. … Elton T.S. (Biochem. Biophys. Res. Commun. 1994) 3 4 23
  2. Angiotensin gene polymorphism as a determinant of posttransplantation renal dysfunction and hypertension. (PMID: 11544438) Abdi R. … Milford E.L. (Transplantation 2001) 3 23 48
  3. Left ventricle mass index and the common, functional, X-linked angiotensin II type-2 receptor gene polymorphism (-1332 G/A) in patients with systemic hypertension. (PMID: 15123577) Alfakih K. … Hall A.S. (Hypertension 2004) 3 23 48
  4. Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP. (PMID: 15123706) Nouet S. … Nahmias C. (J. Biol. Chem. 2004) 3 4 23
  5. Angiotensin II type 2 receptor gene polymorphism and cardiovascular phenotypes: the GLAECO and GLAOLD studies. (PMID: 12453540) Herrmann S.M. … Regitz-Zagrosek V. (Eur. J. Heart Fail. 2002) 3 23 48

Products for AGTR2 Gene

Sources for AGTR2 Gene

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