Aliases for AGTR2 Gene
External Ids for AGTR2 Gene
Previous GeneCards Identifiers for AGTR2 Gene
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation. [provided by RefSeq, Jan 2010]
GeneCards Summary for AGTR2 Gene
AGTR2 (Angiotensin II Receptor Type 2) is a Protein Coding gene. Diseases associated with AGTR2 include non-syndromic x-linked intellectual disability and vesicoureteral reflux. Among its related pathways are cGMP-PKG signaling pathway and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and peptide hormone binding. An important paralog of this gene is ACKR3.
UniProtKB/Swiss-Prot for AGTR2 Gene
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
The angiotensin2 receptor (AT2) is a member of the angiotensin receptor group of G-protein-coupled receptors that also includes AT1 and AT4. They are located primarily in the brain, adrenal medulla, heart and uterus where they counterbalance the effects of AT1.