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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AGTR2 Gene

protein-coding   GIFtS: 67
GCID: GC0XP115216

Angiotensin II Receptor, Type 2

(Previous name: angiotensin receptor 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Angiotensin II Receptor, Type 21 2     Angiotensin Receptor 21
Angiotensin II Type-2 Receptor2 3     ATGR22
AT22 3     Type-2 Angiotensin II Receptor2
MRX882 5     

External Ids:    HGNC: 3381   Entrez Gene: 1862   Ensembl: ENSG000001807727   OMIM: 3000345   UniProtKB: P500523   

Export aliases for AGTR2 gene to outside databases

Previous GC identifers: GC0XP110072 GC0XP112376 GC0XP113316 GC0XP114086 GC0XP115113 GC0XP104838


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AGTR2 Gene:
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor
for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult
tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed
cell death and this apoptotic function may play an important role in developmental biology and pathophysiology.
Mutations in this gene are been associated with X-linked mental retardation. (provided by RefSeq, Jan 2010)

GeneCards Summary for AGTR2 Gene: 
AGTR2 (angiotensin II receptor, type 2) is a protein-coding gene. Diseases associated with AGTR2 include cerebrovascular accident, and conn's syndrome, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and ACE Inhibitor Pathway. GO annotations related to this gene include receptor antagonist activity and transcription factor binding. An important paralog of this gene is RXFP3.

UniProtKB/Swiss-Prot: AGTR2_HUMAN, P50052
Function: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation

summary for AGTR2 Gene:
The angiotensin2 receptors (AT2) are a member of the angiotensin receptor group of G-protein-coupled
receptors that also includes AT1 and AT4. They are located primarily in the brain, adrenal medulla, heart
and uterus where they counterbalance the effects of the AT1 receptor. The human AT2 receptor gene has been
localized to chromosome X (Xq22-q23).

Gene Wiki entry for AGTR2 (Angiotensin II receptor type 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_028405.12  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AGTR2 gene promoter:
         AP-1   ATF-2   IRF-1   CREB   PPAR-gamma1   deltaCREB   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAGTR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for AGTR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGTR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22-q23   Ensembl cytogenetic band:  Xq23   HGNC cytogenetic band: Xq22-q23

AGTR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGTR2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP115216:  view genomic region     (about GC identifiers)

Start:
115,301,958 bp from pter      End:
115,306,225 bp from pter
Size:
4,268 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AGTR2_HUMAN, P50052 (See protein sequence)
Recommended Name: Type-2 angiotensin II receptor  
Size: 363 amino acids; 41184 Da
Subunit: Interacts with MTUS1
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B2R9V1 Q13016 Q6FGY7

Explore the universe of human proteins at neXtProt for AGTR2: NX_P50052

Explore proteomics data for AGTR2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50052

  • AGTR2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AGTR2 Protein Expression
    REFSEQ proteins: NP_000677.2  
    ENSEMBL proteins: 
     ENSP00000360973  
    Reactome Protein details: P50052
    Human Recombinant Protein Products for AGTR2: 
    EMD Millipore Purified and/or Recombinant AGTR2 Protein
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    OriGene Protein Over-expression Lysate for AGTR2
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    Novus Biologicals AGTR2 Proteins
    Novus Biologicals AGTR2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AGTR2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS17159079
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IC10406457
    GO:0016021integral to membrane ----
    GO:0048471perinuclear region of cytoplasm IEA--

    AGTR2 for ontologies           About GeneDecksing



    AGTR2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    AGTR: GPCR / Class A : Angiotensin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: AT2 receptor 
    Angiotensin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000147 ATII_AT2_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR000248 ATII_rcpt

    Graphical View of Domain Structure for InterPro Entry P50052

    ProtoNet protein and cluster: P50052

    2 Blocks protein domains:
    IPB000147 AT2 angiotensin II receptor signature
    IPB000248 Angiotensin II receptor signature


    UniProtKB/Swiss-Prot: AGTR2_HUMAN, P50052
    Similarity: Belongs to the G-protein coupled receptor 1 family


    AGTR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AGTR2_HUMAN, P50052
    Function: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation

         Genatlas biochemistry entry for AGTR2:
    angiotensin II (type-2) receptor,abundantly expressed during embryonic development in fetal tissues,in adrenal
    glands,heart and brain,G protein coupled receptor superfamily,involved in the activation of dephosphorylating
    enzymes,stimulating a phosphotyrosine phosphatase which inhibits guanylate cyclase (involved in blood pressure
    regulation)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004945angiotensin type II receptor activity IPI10406457
    GO:0005515protein binding IPI18344519
    GO:0008134transcription factor binding IEA--
    GO:0017046peptide hormone binding IEA--
         
    AGTR2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for AGTR2:
     Decreased melanin production  Decreased substrate adherent c 

         15 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Agtr2):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  integument  mortality/aging 
     muscle  nervous system  renal/urinary system  skeleton  tumorigenesis 

    AGTR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for AGTR2: Agtr2tm1Tin Agtr2tm1Gsb

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AGTR2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AGTR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AGTR2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AGTR2 

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    SwitchGear 3'UTR luciferase reporter plasmidAGTR2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGTR2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AGTR2 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.46
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.41
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.37
    2Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    ACE Inhibitor Pathway0.85
    ACE Inhibitor Pathway, Pharmacodynamics0.85
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics0.85
    3Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
    Peptide GPCRs0.46
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    5p70S6K Signaling
    Renin-Angiotensin Pathway0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for AGTR2
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AGTR2
        Renin-Angiotensin Pathway
    JAK-STAT Pathway
    Signaling Involved in Cardiac Hypertrophy

    3 BioSystems Pathways for AGTR2
        ACE Inhibitor Pathway
    GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    5/7        Reactome Pathways for AGTR2 (see all 7)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events

    2 PharmGKB Pathways for AGTR2
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for AGTR2):
        Neuroactive ligand-receptor interaction
    Renin-angiotensin system


    AGTR2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AGTR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/156 Interacting proteins for AGTR2 (P500521, 3 ENSP000003609734) via UniProtKB, MINT, STRING, and/or I2D (see all 156)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TIMP3P356251, 3, ENSP000002660854EBI-1748067,EBI-1748085 I2D: score=1 STRING: ENSP00000266085
    AGTP010193, ENSP000003556274I2D: score=2 STRING: ENSP00000355627
    ACEP128213, ENSP000002908664I2D: score=1 STRING: ENSP00000290866
    AGTRAPQ6RW133, ENSP000003197134I2D: score=1 STRING: ENSP00000319713
    PIK3CBP423383, ENSP000002891534I2D: score=1 STRING: ENSP00000289153
    About this table

    Gene Ontology (GO): 5/43 biological process terms (GO ID links to tree view) (see all 43):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001822kidney development ----
    GO:0001974blood vessel remodeling TAS17159080
    GO:0001991regulation of systemic arterial blood pressure by circulatory renin-angiotensin ISS--
    GO:0002018renin-angiotensin regulation of aldosterone production IEA--
    GO:0002033vasodilation by angiotensin involved in regulation of systemic arterial blood pressure IEA--

    AGTR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AGTR2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for AGTR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CGP 42112 Selective, high affinity AT2 ligand [127060-75-7]
    NovokininOrally active AT2 agonist[358738-77-9]
    PD 123319 ditrifluoroacetate Potent, selective non-peptide AT2 antagonist [130663-39-7]

    1 HMDB Compound for AGTR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Angiotensin IIHypertensin (see all 11)11128-99-7--

    1 DrugBank Compound for AGTR2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Tasosartan-- 145733-36-4targetantagonist11683476

    6 IUPHAR Ligands for AGTR2 (AT2 receptor)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [125I]CGP42112
    AgonistFull agonist10.62775266 1764088
    angiotensin III
    AgonistFull agonist10.48242249 2775266
    angiotensin II
    AgonistFull agonist10.22775266 7850406
    CGP42112
    AgonistFull agonist9.6321542804
    PD123319
    AntagonistAntagonist8.7 - 9.21709220 2402226
    angiotensin I
    AgonistFull agonist7.32775266

    10/41 Novoseek inferred chemical compound relationships for AGTR2 gene (see all 41)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cgp42112a 92.7 14 8920914 (2), 7957644 (2), 7484433 (1), 9239679 (1) (see all 10)
    pd123319 92.2 28 7957644 (2), 9918526 (1), 10419063 (1), 8920914 (1) (see all 23)
    losartan 83.8 50 11801934 (2), 7957644 (2), 8821748 (2), 9918526 (1) (see all 39)
    ang ii 81.4 29 9888501 (3), 12826071 (2), 16112405 (2), 10405785 (2) (see all 18)
    etoperidone 71.4 2 15960425 (2)
    irbesartan 59.5 7 14506547 (2), 15037537 (1), 15277414 (1), 17877649 (1) (see all 5)
    telmisartan 55 1 16372586 (1)
    valsartan 54.2 2 14506547 (2)
    candesartan 49.9 2 11030714 (1), 10903218 (1)
    phosphotyrosine 40.9 4 7749365 (1), 7484433 (1), 7713098 (1), 7829501 (1)

    Search CenterWatch for drugs/clinical trials and news about AGTR2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AGTR2 gene: 
    NM_000686.4  

    Unigene Cluster for AGTR2:

    Angiotensin II receptor, type 2
    Hs.405348  [show with all ESTs]
    Unigene Representative Sequence: NM_000686
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371906(uc004eqh.4)

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGTR2
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGTR2

    Additional mRNA sequence: 

    AK313927.1 BC095504.1 CR541969.1 U16957.1 X87723.1 

    2 DOTS entries:

    DT.110560  DT.101965973 

    24/26 AceView cDNA sequences (see all 26):

    CR541969 CF147787 AI911273 CO248117 CO247675 U16957 CO249038 CO247783 
    NM_000686 CO246596 CO249271 CO248442 BV183222 AA089494 AI392646 X87723 
    CO249037 CO248200 AA780321 AW514178 N84440 AA347561 BE825708 AL036903 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AGTR2 expression in normal human tissues (normalized intensities)      AGTR2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AGTR2 Expression
    About this image


    AGTR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Septum   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Intervertebral Disc Annulus Fibrosus Cells Lumbar Intervertebral Disc
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Dermis (Integumentary System)
             Dermal Fibroblasts Dorsal Dermis

    See AGTR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AGTR2

    SOURCE GeneReport for Unigene cluster: Hs.405348

    UniProtKB/Swiss-Prot: AGTR2_HUMAN, P50052
    Tissue specificity: In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian
    tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine

        SABiosciences Expression via Pathway-Focused PCR Arrays including AGTR2: 
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              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AGTR2 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agtr21 , 5 angiotensin II receptor, type 21, 5 89.16(n)1
    91.74(a)1
      X (16.71 cM)5
    116091  NM_007429.41  NP_031455.11 
     214845445 
    chicken
    (Gallus gallus)
    Aves AGTR21 angiotensin II receptor, type 2 62.62(n)
    53.04(a)
      428708  XM_426266.3  XP_426266.2 
    lizard
    (Anolis carolinensis)
    Reptilia AGTR26
    Uncharacterized protein
    47(a)
    1 ↔ 1
    GL343403.1(515334-516485)
    zebrafish
    (Danio rerio)
    Actinopterygii agtr21 angiotensin II receptor, type 2 53.78(n)
    46.01(a)
      503772  NM_001013350.1  NP_001013368.1 


    ENSEMBL Gene Tree for AGTR2 (if available)
    TreeFam Gene Tree for AGTR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AGTR2 gene
    RXFP32  BDKRB12  GPR252  AGTR12  APLNR2  BDKRB22  ACKR32  GPR152  
    RXFP42  GPR1822  
    18/46 SIMAP similar genes for AGTR2 using alignment to 1 protein entry:     AGTR2_HUMAN(see all similar genes):
    ATGR2    AGTR1    CCR2    CCR4    CXCR2    IL8RB
    LPAR6    P2RY5    CCR8    BDKRB2    CCR1    CMKLR1
    CYSLTR2    DKFZp686O088    GPR1    KPG_011    LPAR4    OPRK1

    AGTR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/134 SNPs in AGTR2 are shown (see all 134)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0659484
    Mental retardation, X-linked 88 (MRX88)4--see VAR_0659482 I V mis40--------
    rs1219178101,2,4
    C,FMental retardation, X-linked 88 (MRX88)4 pathogenic1115292164(+) CTTCGG/TGCTTG 2 G V mis11Minor allele frequency- T:0.00NA 4538
    rs354746571,2,4
    C,FMental retardation, X-linked 88 (MRX88)4 pathogenic1115293073(-) GGAACC/TGGTTT 2 Q R mis14Minor allele frequency- T:0.00NA 4618
    rs1219178131,2
    Cpathogenic1115292259(+) ACTACA/TTTATA 2 I F mis10--------
    rs1219178111,2
    Cpathogenic1115293111(+) TTCCAA/GTTACT 2 I V mis10--------
    rs59505851,2
    C,H--115288555(+) GTTTCC/TGAAAC 1 -- us2k18Minor allele frequency- T:0.00WA NA CSA 14
    rs59505861,2
    C,F,A,H--115288752(+) TTCACG/ATAACG 1 -- us2k112Minor allele frequency- A:0.01NS EA WA NA CSA 432
    rs1922670341,2
    --115288865(+) ATTTGC/TAATTT 1 -- us2k10--------
    rs1851694891,2
    --115288940(+) AGCTAC/TTTCCT 1 -- us2k10--------
    rs172377501,2
    C,F--115288956(+) CCTGCC/ACTCAT 1 -- us2k13Minor allele frequency- A:0.07NS CSA 131

    HapMap Linkage Disequilibrium report for AGTR2 (115301958 - 115306225 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AGTR2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv9965CNV Gain18304495
    dgv2466e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): AGTR2

    Locus Specific Mutation Databases (LSDB): AGTR2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300034    OMIM disorders: --

    UniProtKB/Swiss-Prot: AGTR2_HUMAN, P50052
  • Mental retardation, X-linked 88 (MRX88) [MIM:300852]: A disorder characterized by significantly below
    average general intellectual functioning associated with impairments in adaptative behavior and manifested during
    the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental
    retardation, while syndromic mental retardation presents with associated physical, neurological and/or
    psychiatric manifestations. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/65 diseases for AGTR2 (see all 65):    About MalaCards
    cerebrovascular accident    conn's syndrome    hydronephrosis    hypertrophic scars
    end stage renal failure    vesicoureteral reflux    myocardial stunning    renal agenesis
    ureteral obstruction    angioedema    essential hypertension    cushing's syndrome
    congestive heart failure    pulmonary tuberculosis    turner syndrome    premature ovarian failure
    mental retardation    hypertrophic cardiomyopathy    hypertension    pheochromocytoma


    AGTR2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/54 Novoseek inferred disease relationships for AGTR2 gene (see all 54)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetic nephropathies 52.2 3 14632698 (1), 16780569 (1), 18454253 (1)
    cardiac hypertrophy 51.5 1 11751703 (1)
    ventricular hypertrophy 49.4 7 20467270 (2), 17944121 (1), 17319472 (1), 17620959 (1) (see all 6)
    renal disease 48.5 15 15756705 (1), 16372586 (1), 19404281 (1), 15153562 (1) (see all 11)
    hypertrophy 46.1 3 16286564 (2), 11728881 (1)
    cardiovascular diseases 39.7 7 9449684 (1), 19861349 (1), 8773261 (1), 14707017 (1) (see all 6)
    heart failure 37.7 7 8957548 (1), 10361430 (1), 9054850 (1), 10727655 (1) (see all 5)
    pheochromocytoma 32.4 4 7484433 (1), 10361432 (1), 7713098 (1), 18296263 (1)
    nephropathy obstructive 32.2 1 16133060 (1)
    myocardial infarction 31.2 9 14506547 (4), 10361430 (1), 11224700 (1), 14632698 (1) (see all 5)

    Genetic Association Database (GAD): AGTR2
    Human Genome Epidemiology (HuGE) Navigator: AGTR2 (104 documents)

    Export disorders for AGTR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AGTR2 gene, integrated from 9 sources (see all 426):
    (articles sorted by number of sources associating them with AGTR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Angiotensin II type 2 receptor gene is not responsible for familial vesicoureteral reflux. (PubMed id 12187255)1, 4, 9 Yoneda A....Puri P. (2002)
    2. Role of the angiotensin II type 2 receptor gene (+167 5G/A) polymorphism on left ventricular hypertrophy and geometry in treated hype rtensive patients. (PubMed id 20467270)1, 4, 9 Huber M....Kreutz R. (2010)
    3. The AT2 gene may have a gender-specific effect on kidney function and pulse pressure in type I diabetic patients. (PubMed id 16598200)1, 4, 9 Pettersson-Fernholm K....Groop P.H. (2006)
    4. Implication of genetic variations in congenital obstructive nephropathy. (PubMed id 16133060)1, 4, 9 Hahn H....Cheong H.I. (2005)
    5. Angiotensin II type 2 receptor gene polymorphism and cardiovascular phenotypes: the GLAECO and GLAOLD studies. (PubMed id 12453540)1, 4, 9 Herrmann S.M....Regitz-Zagrosek V. (2002)
    6. [Mutation screening in Angiotensin II receptors, AGTR1 and AGTR2, and evaluation of AGTR1 polymorphisms C573T and A1166C in patients with premature adrenarche] (PubMed id 17160213)1, 4, 9 Moura M.S....Monte O. (2006)
    7. [Relation between the angiotensin II type 2 receptor polymorphism and essential hypertension in men] (PubMed id 16080803)1, 4, 9 Qiao W.W....Xu S.J. (2005)
    8. Angiotensin gene polymorphism as a determinant of posttransplantation renal dysfunction and hypertension. (PubMed id 11544438)1, 4, 9 Abdi R....Milford E.L. (2001)
    9. Angiotensin II type 2 receptor gene polymorphism in Caucasian children with a wide spectrum of congenital anomalies of the kidney and urinary tract. (PubMed id 17515833)1, 4, 9 Siomou E....Siamopoulou A. (2007)
    10. Angiotensin II type 2 receptor gene polymorphisms and essential hypertension. (PubMed id 14627490)1, 4, 9 Zhang Y....Zhu D.L. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 186 HGNC: 338 AceView: AGTR2 Ensembl:ENSG00000180772 euGenes: HUgn186
    ECgene: AGTR2 Kegg: 186 H-InvDB: AGTR2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AGTR2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/AGTR2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AGTR2 gene:
    Search GeneIP for patents involving AGTR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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