Aliases for AGTR2 Gene
External Ids for AGTR2 Gene
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation. [provided by RefSeq, Jan 2010]
GeneCards Summary for AGTR2 Gene
AGTR2 (Angiotensin II Receptor, Type 2) is a Protein Coding gene. Diseases associated with AGTR2 include hypertrophic scars and posterior urethral valves. Among its related pathways are Signaling by GPCR and p70S6K Signaling. GO annotations related to this gene include transcription factor binding and receptor antagonist activity. An important paralog of this gene is ACKR3.
UniProtKB/Swiss-Prot for AGTR2 Gene
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
The angiotensin2 receptors (AT2) are a member of the angiotensin receptor group of G-protein-coupled receptors that also includes AT1 and AT4. They are located primarily in the brain, adrenal medulla, heart and uterus where they counterbalance the effects of the AT1 receptor. The human AT2 receptor gene has been localized to chromosome X (Xq22-q23).