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AGTR2 Gene

protein-coding   GIFtS: 67
GCID: GC0XP115216

Angiotensin II Receptor, Type 2

(Previous name: angiotensin receptor 2)
  See AGTR2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Angiotensin II Receptor, Type 21 2     ATGR22
Angiotensin II Type-2 Receptor2 3     MRX882
AT22 3     Type-2 Angiotensin II Receptor2
Angiotensin Receptor 21     

External Ids:    HGNC: 3381   Entrez Gene: 1862   Ensembl: ENSG000001807727   OMIM: 3000345   UniProtKB: P500523   

Export aliases for AGTR2 gene to outside databases

Previous GC identifers: GC0XP110072 GC0XP112376 GC0XP113316 GC0XP114086 GC0XP115113 GC0XP104838


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AGTR2 Gene:
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor
for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult
tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed
cell death and this apoptotic function may play an important role in developmental biology and pathophysiology.
Mutations in this gene are been associated with X-linked mental retardation. (provided by RefSeq, Jan 2010)

GeneCards Summary for AGTR2 Gene:
AGTR2 (angiotensin II receptor, type 2) is a protein-coding gene. Diseases associated with AGTR2 include posterior urethral valves, and posterior urethral valve. GO annotations related to this gene include receptor antagonist activity and transcription factor binding. An important paralog of this gene is RXFP3.

UniProtKB/Swiss-Prot: AGTR2_HUMAN, P50052
Function: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation

summary for AGTR2 Gene:
The angiotensin2 receptors (AT2) are a member of the angiotensin receptor group of G-protein-coupled
receptors that also includes AT1 and AT4. They are located primarily in the brain, adrenal medulla, heart
and uterus where they counterbalance the effects of the AT1 receptor. The human AT2 receptor gene has been
localized to chromosome X (Xq22-q23).

Gene Wiki entry for AGTR2 (Angiotensin II receptor type 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_028405.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the AGTR2 gene promoter:
         AP-1   ATF-2   IRF-1   CREB   PPAR-gamma1   deltaCREB   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAGTR2 promoter sequence
   Search Chromatin IP Primers for AGTR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGTR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22-q23   Ensembl cytogenetic band:  Xq23   HGNC cytogenetic band: Xq22-q23

AGTR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGTR2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP115216:  view genomic region     (about GC identifiers)

Start:
115,301,958 bp from pter      End:
115,306,225 bp from pter
Size:
4,268 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AGTR2_HUMAN, P50052 (See protein sequence)
Recommended Name: Type-2 angiotensin II receptor  
Size: 363 amino acids; 41184 Da
Subunit: Interacts with MTUS1
Caution: Although AGTR2 has been reported to be involved in X-linked mental retardation (PubMed:12089445), its
pathological role is questionable (PubMed:23871722)
Secondary accessions: B2R9V1 Q13016 Q6FGY7

Explore the universe of human proteins at neXtProt for AGTR2: NX_P50052

Explore proteomics data for AGTR2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn4, Asn13, Asn24, Asn29, Asn34
  • Modification sites at PhosphoSitePlus

  • See AGTR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000677.2  
    ENSEMBL proteins: 
     ENSP00000360973  
    Reactome Protein details: P50052

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    Novus Biologicals AGTR2 Proteins
    Novus Biologicals AGTR2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AGTR2

     
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    antibodies-online proteins for AGTR2 (2 products) 

     
    antibodies-online peptides for AGTR2

    AGTR2 Antibody Products:

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    Search for Antibodies for AGTR2 at Abcam
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    antibodies-online antibodies for AGTR2 (52 products) 

    AGTR2 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AGTR: GPCR / Class A : Angiotensin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: AT2 receptor
    Angiotensin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000147 ATII_AT2_rcpt
     IPR000248 ATII_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P50052

    ProtoNet protein and cluster: P50052

    2 Blocks protein domains:
    IPB000147 AT2 angiotensin II receptor signature
    IPB000248 Angiotensin II receptor signature


    UniProtKB/Swiss-Prot: AGTR2_HUMAN, P50052
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with AGTR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AGTR2_HUMAN, P50052
    Function: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation

         Genatlas biochemistry entry for AGTR2:
    angiotensin II (type-2) receptor,abundantly expressed during embryonic development in fetal tissues,in adrenal
    glands,heart and brain,G protein coupled receptor superfamily,involved in the activation of dephosphorylating
    enzymes,stimulating a phosphotyrosine phosphatase which inhibits guanylate cyclase (involved in blood pressure
    regulation)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004945angiotensin type II receptor activity IPI10406457
    GO:0005515protein binding IPI10406457
    GO:0008134transcription factor binding IEA--
    GO:0017046peptide hormone binding IEA--
         
    Find genes that share ontologies with AGTR2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for AGTR2:
     Decreased melanin production  Decreased substrate adherent c 

         15 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Agtr2):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  integument  mortality/aging 
     muscle  nervous system  renal/urinary system  skeleton  tumorigenesis 

    Find genes that share phenotypes with AGTR2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for AGTR2: Agtr2tm1Tin Agtr2tm1Gsb

       genOway: Develop your customized and physiologically relevant rodent model for AGTR2

    miRNA
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    miRTarBase miRNAs that target AGTR2:
    hsa-mir-148b-3p (MIRT019253), hsa-mir-124-3p (MIRT022332), hsa-mir-142-3p (MIRT021590)

    Block miRNA regulation of human, mouse, rat AGTR2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate AGTR2:
    hsa-miR-539 hsa-miR-3074-3p hsa-miR-548t hsa-miR-3919 hsa-miR-330-3p hsa-miR-3145-3p hsa-miR-1299 hsa-miR-384
    SwitchGear 3'UTR luciferase reporter plasmidAGTR2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: AGTR2 (NM_000686)
    Sino Biological Human cDNA Clone for AGTR2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AGTR2_HUMAN, P50052: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS17159079
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IC10406457
    GO:0016021integral component of membrane ----
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with AGTR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AGTR2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics0.37
    ACE Inhibitor Pathway, Pharmacodynamics0.00
    Renin-angiotensin system0.37
    ACE Inhibitor Pathway0.00
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5p70S6K Signaling
    Renin-Angiotensin Pathway0.60


    Find genes that share SuperPaths with AGTR2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for AGTR2
        Renin-Angiotensin Pathway
    JAK-STAT Pathway
    Signaling Involved in Cardiac Hypertrophy

    3 BioSystems Pathways for AGTR2
        ACE Inhibitor Pathway
    GPCRs, Class A Rhodopsin-like
    Peptide GPCRs


    2 Reactome Pathways for AGTR2
        Peptide ligand-binding receptors
    G alpha (i) signalling events

    2 PharmGKB Pathways for AGTR2
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

    3 Kegg Pathways  (Kegg details for AGTR2):
        Neuroactive ligand-receptor interaction
    Adrenergic signaling in cardiomyocytes
    Renin-angiotensin system

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AGTR2: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AGTR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AGTR2 (P500521, 3 ENSP000003609734) via UniProtKB, MINT, STRING, and/or I2D (see all 156)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGTP010191, 3, ENSP000003556274EBI-1748067,EBI-2927577 I2D: score=2 STRING: ENSP00000355627
    TIMP3P356251, 3, ENSP000002660854EBI-1748067,EBI-1748085 I2D: score=1 STRING: ENSP00000266085
    ACEP128213, ENSP000002908664I2D: score=1 STRING: ENSP00000290866
    AGTRAPQ6RW133, ENSP000003197134I2D: score=1 STRING: ENSP00000319713
    PIK3CBP423383, ENSP000002891534I2D: score=1 STRING: ENSP00000289153
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 45):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001822kidney development ----
    GO:0001974blood vessel remodeling TAS17159080
    GO:0001991regulation of systemic arterial blood pressure by circulatory renin-angiotensin ISS--
    GO:0002018renin-angiotensin regulation of aldosterone production IEA--
    GO:0002033vasodilation by angiotensin involved in regulation of systemic arterial blood pressure IEA--

    Find genes that share ontologies with AGTR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for AGTR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CGP 42112 Selective, high affinity AT2 ligand [127060-75-7]
    NovokininOrally active AT2 agonist[358738-77-9]
    PD 123319 ditrifluoroacetate Potent, selective non-peptide AT2 antagonist [130663-39-7]

    1 HMDB Compound for AGTR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Angiotensin IIHypertensin (see all 11)11128-99-7--

    1 DrugBank Compound for AGTR2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Tasosartan-- 145733-36-4targetantagonist11683476

    6 IUPHAR Ligands for AGTR2 (AT2 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I]CGP42112
    AgonistFull agonist10.62775266 1764088
    angiotensin III
    AgonistFull agonist10.48242249 2775266
    angiotensin II
    AgonistFull agonist10.22775266 7850406
    CGP42112
    AgonistFull agonist9.6321542804
    PD123319
    AntagonistAntagonist8.7 - 9.21709220 2402226
    angiotensin I
    AgonistFull agonist7.32775266

    Selected Novoseek inferred chemical compound relationships for AGTR2 gene (see all 41)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cgp42112a 92.7 14 8920914 (2), 7957644 (2), 7484433 (1), 9239679 (1) (see all 10)
    pd123319 92.2 28 7957644 (2), 9918526 (1), 10419063 (1), 8920914 (1) (see all 23)
    losartan 83.8 50 11801934 (2), 7957644 (2), 8821748 (2), 9918526 (1) (see all 39)
    ang ii 81.4 29 9888501 (3), 12826071 (2), 16112405 (2), 10405785 (2) (see all 18)
    etoperidone 71.4 2 15960425 (2)
    irbesartan 59.5 7 14506547 (2), 15037537 (1), 15277414 (1), 17877649 (1) (see all 5)
    telmisartan 55 1 16372586 (1)
    valsartan 54.2 2 14506547 (2)
    candesartan 49.9 2 11030714 (1), 10903218 (1)
    phosphotyrosine 40.9 4 7749365 (1), 7484433 (1), 7713098 (1), 7829501 (1)



    Find genes that share compounds with AGTR2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AGTR2 gene: 
    NM_000686.4  

    Unigene Cluster for AGTR2:

    Angiotensin II receptor, type 2
    Hs.405348  [show with all ESTs]
    Unigene Representative Sequence: NM_000686
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371906(uc004eqh.4)
    miRNA
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    hsa-miR-539 hsa-miR-3074-3p hsa-miR-548t hsa-miR-3919 hsa-miR-330-3p hsa-miR-3145-3p hsa-miR-1299 hsa-miR-384
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      QuantiFast Probe-based Assays in human, mouse, rat AGTR2

    Additional mRNA sequence: 

    AK313927.1 BC095504.1 CR541969.1 U16957.1 X87723.1 

    2 DOTS entries:

    DT.110560  DT.101965973 

    Selected AceView cDNA sequences (see all 26):

    CR541969 CF147787 NM_000686 AI911273 U16957 CO248117 CO247783 CO247675 
    CO249038 CO249271 AA780321 X87723 CO246596 AA089494 AI392646 CO248200 
    BV183222 CO248442 CO249037 AW514178 N84440 AA347561 BE825708 CO249260 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AGTR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AGTR2 Expression
    About this image


    AGTR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Lung (Respiratory System)
             Alveolar type II cells
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
     
     Cartilage (Muscoskeletal System)
             Intervertebral Disc Annulus Fibrosus Cells Annulus Fibrosus
    AGTR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AGTR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.405348

    UniProtKB/Swiss-Prot: AGTR2_HUMAN, P50052
    Tissue specificity: In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian
    tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AGTR2: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for AGTR2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGTR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AGTR2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agtr21 , 5 angiotensin II receptor, type 21, 5 89.16(n)1
    91.74(a)1
      X (16.71 cM)5
    116091  NM_007429.51  NP_031455.11 
     214845445 
    chicken
    (Gallus gallus)
    Aves AGTR21 angiotensin II receptor, type 2 62.62(n)
    53.04(a)
      428708  XM_004940660.1  XP_004940717.1 
    lizard
    (Anolis carolinensis)
    Reptilia AGTR26
    angiotensin II receptor, type 2
    47(a)
    1 ↔ 1
    GL343403.1(515334-516485)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia agtr21 angiotensin 2 receptor, type 2 58.53(n)
    50.3(a)
      779906  NM_001078984.1  NP_001072452.1 
    zebrafish
    (Danio rerio)
    Actinopterygii agtr21 angiotensin II receptor, type 2 53.41(n)
    46.49(a)
      503772  NM_001013350.2  NP_001013368.1 


    ENSEMBL Gene Tree for AGTR2 (if available)
    TreeFam Gene Tree for AGTR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AGTR2 gene
    RXFP32  BDKRB12  GPR252  AGTR12  APLNR2  BDKRB22  ACKR32  GPR152  
    RXFP42  GPR1822  
    Selected SIMAP similar genes for AGTR2 using alignment to 1 protein entry:     AGTR2_HUMAN(see all similar genes):
    ATGR2    AGTR1    CCR2    CCR4    CXCR2    IL8RB
    LPAR6    CCR8    BDKRB2    CCR1    CMKLR1    CYSLTR2
    DKFZp686O088    GPR1    KPG_011    LPAR4    OPRK1    SSTR2

    Find genes that share paralogs with AGTR2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AGTR2 (see all 134)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219178101,2,,4
    C,Fpathogenic1115292164(+) CTTCGG/TGCTTG 2 G V mis11Minor allele frequency- T:0.00NA 4538
    rs1219178131,2
    Cpathogenic1115292259(+) ACTACA/TTTATA 2 I F mis10--------
    rs354746571,2,,4
    C,Fpathogenic1115293073(-) GGAACC/TGGTTT 2 Q R mis14Minor allele frequency- T:0.00NA 4618
    rs1219178111,2
    Cpathogenic1115293111(+) TTCCAA/GTTACT 2 I V mis10--------
    rs59505851,2
    C,H--115288555(+) GTTTCC/TGAAAC 1 -- us2k18Minor allele frequency- T:0.00WA NA CSA 14
    rs59505861,2
    C,F,A,H--115288752(+) TTCACG/ATAACG 1 -- us2k112Minor allele frequency- A:0.01NS EA WA NA CSA 432
    rs1922670341,2
    --115288865(+) ATTTGC/TAATTT 1 -- us2k10--------
    rs1851694891,2
    --115288940(+) AGCTAC/TTTCCT 1 -- us2k10--------
    rs172377501,2
    C,F--115288956(+) CCTGCC/ACTCAT 1 -- us2k13Minor allele frequency- A:0.07NS CSA 131
    rs1904464701,2
    --115289023(+) TATGAA/TCCACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AGTR2 (115301958 - 115306225 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AGTR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv9965CNV Gain18304495
    dgv2466e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): AGTR2
    Locus Specific Mutation Databases (LSDB): AGTR2

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300034    OMIM disorders: --

    11 diseases for AGTR2:    
    About MalaCards
    posterior urethral valves    posterior urethral valve    hypertrophic scars    multicystic dysplastic kidney
    myocardial stunning    hydronephrosis    vesicoureteral reflux    mental retardation, x-linked 17/31, microduplication
    renal agenesis    essential hypertension    coronary artery disease


    Find genes that share disorders with AGTR2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for AGTR2 gene (see all 54)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetic nephropathies 52.2 3 14632698 (1), 16780569 (1), 18454253 (1)
    cardiac hypertrophy 51.5 1 11751703 (1)
    ventricular hypertrophy 49.4 7 20467270 (2), 17944121 (1), 17319472 (1), 17620959 (1) (see all 6)
    renal disease 48.5 15 15756705 (1), 16372586 (1), 19404281 (1), 15153562 (1) (see all 11)
    hypertrophy 46.1 3 16286564 (2), 11728881 (1)
    cardiovascular diseases 39.7 7 9449684 (1), 19861349 (1), 8773261 (1), 14707017 (1) (see all 6)
    heart failure 37.7 7 8957548 (1), 10361430 (1), 9054850 (1), 10727655 (1) (see all 5)
    pheochromocytoma 32.4 4 7484433 (1), 10361432 (1), 7713098 (1), 18296263 (1)
    nephropathy obstructive 32.2 1 16133060 (1)
    myocardial infarction 31.2 9 14506547 (4), 10361430 (1), 11224700 (1), 14632698 (1) (see all 5)

    Genetic Association Database (GAD): AGTR2
    Human Genome Epidemiology (HuGE) Navigator: AGTR2 (104 documents)

    Export disorders for AGTR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AGTR2 gene, integrated from 10 sources (see all 430):
    (articles sorted by number of sources associating them with AGTR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Angiotensin II type 2 receptor gene is not responsible for familial vesicoureteral reflux. (PubMed id 12187255)1, 4, 9 Yoneda A....Puri P. (J. Urol. 2002)
    2. Role of the angiotensin II type 2 receptor gene (+1675G/A) polymorphism on left ventricular hypertrophy and geometry in treated hypertensive patients. (PubMed id 20467270)1, 4, 9 Huber M....Kreutz R. (J. Hypertens. 2010)
    3. The AT2 gene may have a gender-specific effect on kidney function and pulse pressure in type I diabetic patients. (PubMed id 16598200)1, 4, 9 Pettersson-Fernholm K....Groop P.H. (Kidney Int. 2006)
    4. Implication of genetic variations in congenital obstructive nephropathy. (PubMed id 16133060)1, 4, 9 Hahn H....Cheong H.I. (Pediatr. Nephrol. 2005)
    5. Angiotensin II type 2 receptor gene polymorphism and cardiovascular phenotypes: the GLAECO and GLAOLD studies. (PubMed id 12453540)1, 4, 9 Herrmann S.M....Regitz-Zagrosek V. (Eur. J. Heart Fail. 2002)
    6. [Mutation screening in Angiotensin II receptors, AGTR1 and AGTR2, and evaluation of AGTR1 polymorphisms C573T and A1166C in patients with premature adrenarche]. (PubMed id 17160213)1, 4, 9 Moura M.S....Monte O. (Arq Bras Endocrinol Metabol 2006)
    7. [Relation between the angiotensin II type 2 receptor polymorphism and essential hypertension in men]. (PubMed id 16080803)1, 4, 9 Qiao W.W....Xu S.J. (Zhonghua Xin Xue Guan Bing Za Zhi 2005)
    8. Angiotensin gene polymorphism as a determinant of posttransplantation renal dysfunction and hypertension. (PubMed id 11544438)1, 4, 9 Abdi R....Milford E.L. (Transplantation 2001)
    9. Angiotensin II type 2 receptor gene polymorphism in Caucasian children with a wide spectrum of congenital anomalies of the kidney and urinary tract. (PubMed id 17515833)1, 4, 9 Siomou E....Siamopoulou A. (Pediatr. Res. 2007)
    10. Angiotensin II type 2 receptor gene polymorphisms and essential hypertension. (PubMed id 14627490)1, 4, 9 Zhang Y....Zhu D.L. (Acta Pharmacol. Sin. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 186 HGNC: 338 AceView: AGTR2 Ensembl:ENSG00000180772 euGenes: HUgn186
    ECgene: AGTR2 Kegg: 186 H-InvDB: AGTR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AGTR2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=AGTR2[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AGTR2 gene:
    Search GeneIP for patents involving AGTR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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