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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AGTR2 Gene

protein-coding GIFtS: 68
GCID: GC0XP115216

angiotensin II receptor, type 2

(Previous name: angiotensin receptor 2 )

Explore 68 diseases affiliated with
AGTR2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Angiotensin II Receptor, Type 2¹ ²		Angiotensin Receptor 2¹
AT2¹ ² ³		ATGR2²
MRX88¹ ² ⁵		Type-2 Angiotensin II Receptor²
Angiotensin II Type-2 Receptor² ³

External Ids:	HGNC: 338¹	Entrez Gene: 186²	Ensembl: ENSG00000180772⁷	OMIM: 300034⁵	UniProtKB: P50052³

Export aliases for AGTR2 gene to outside databases

Previous GC identifers: GC0XP110072 GC0XP112376 GC0XP113316 GC0XP114086 GC0XP115113 GC0XP104838

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AGTR2:

The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for

angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues,

except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and

this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this

gene are been associated with X-linked mental retardation. (provided by RefSeq, Jan 2010)

UniProtKB/Swiss-Prot: AGTR2_HUMAN, P50052

Function: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation

summary for AGTR2:

The angiotensin2 receptors (AT2) is a member of the angiotensin receptor group of G-protein-coupled

receptors that also includes AT1 and AT4. They are located primarily in the brain, adrenal medulla, heart

and uterus where they counterbalance the effects of the AT1 receptor. The human AT2 receptor gene has been

localized to chromosome X (Xq22-q23).

Gene Wiki entry for AGTR2 (Angiotensin II receptor type 2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_028405.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AGTR2 gene promoter:
AP-1 ATF-2 IRF-1 CREB PPAR-gamma1 deltaCREB PPAR-gamma2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AGTR2 promoter sequence

Search SABiosciences Chromatin IP Primers for AGTR2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGTR2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22-q23 Ensembl cytogenetic band: Xq23 HGNC cytogenetic band: Xq22-q23

AGTR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGTR2 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP115216: view genomic region (about GC identifiers)

Start:	115,301,958 bp from pter	End:	115,306,225 bp from pter
Size:	4,268 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AGTR2_HUMAN, P50052 (See protein sequence)

Recommended Name: Type-2 angiotensin II receptor

Size: 363 amino acids; 41184 Da

Subunit: Interacts with MTUS1

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: B2R9V1 Q13016 Q6FGY7

Explore the universe of human proteins at neXtProt for AGTR2: NX_P50052

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P50052

AGTR2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000677.2

ENSEMBL proteins:

ENSP00000360973

Reactome Protein details: P50052
Human Recombinant Protein Products:

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	Uscn Proteins for AGTR2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	17159079
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	IC	10406457
GO:0048471	perinuclear region of cytoplasm	IEA	--

AGTR2 for ontologies About GeneDecksing

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for AGTR2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AGTR2 for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR000147 ATII_AT2_rcpt

IPR000276 GPCR_Rhodpsn

IPR000248 ATII_rcpt

Graphical View of Domain Structure for InterPro Entry P50052

ProtoNet protein and cluster: P50052

2 Blocks protein families:

IPB000147 AT2 angiotensin II receptor signature

IPB000248 Angiotensin II receptor signature

UniProtKB/Swiss-Prot: AGTR2_HUMAN, P50052

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: AGTR2_HUMAN, P50052

Function: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation

Genatlas biochemistry entry for AGTR2:

angiotensin II (type-2) receptor,abundantly expressed during embryonic development in fetal tissues,in adrenal

glands,heart and brain,G protein coupled receptor superfamily,involved in the activation of dephosphorylating

enzymes,stimulating a phosphotyrosine phosphatase which inhibits guanylate cyclase (involved in blood pressure

regulation)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AGTR2
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate AGTR2:
		hsa-miR-539 hsa-miR-3074-3p hsa-miR-548t hsa-miR-3919 hsa-miR-330-3p hsa-miR-3145-3p hsa-miR-1299 hsa-miR-384

		SwitchGear 3'UTR luciferase reporter plasmid: AGTR2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AGTR2 (see all 7) OriGene shRNA RFP: AGTR2 OriGene siRNA: AGTR2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGTR2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for AGTR2

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGTR2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGTR2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: AGTR2 (NM_000686)
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		Search LifeMap BioReagents cell lines for AGTR2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGTR2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004945	angiotensin type II receptor activity	IPI	10406457
GO:0005515	protein binding	IPI	18344519
GO:0008134	transcription factor binding	IEA	--
GO:0017046	peptide hormone binding	IEA	--
GO:0048019	receptor antagonist activity	TAS	17159079

AGTR2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for AGTR2:

Decreased melanin production

Decreased substrate adherent c

Animal Models:
Mouse knock-outs for AGTR2: Agtr2^tm1Tin Agtr2^tm1Gsb
15 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Agtr2):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
endocrine/exocrine gland	growth/size	homeostasis/metabolism	integument	mortality/aging
muscle	nervous system	renal/urinary system	skeleton	tumorigenesis

AGTR2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	G alpha (i) signalling events	0.44
GPCR ligand binding	0.75	GPCRs, Class A Rhodopsin-like	0.41
Peptide ligand-binding receptors	0.61	Neuroactive ligand-receptor interaction	0.38

Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics	1.00			ACE Inhibitor Pathway	0.85
	ACE Inhibitor Pathway, Pharmacodynamics	1.00

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1.00

Peptide GPCRs

0.46

Renin-angiotensin system

Renin-angiotensin system

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for AGTR2

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AGTR2

	Renin-Angiotensin Pathway
	JAK-STAT Pathway
	Signaling Involved in Cardiac Hypertrophy

3 BioSystems Pathways for AGTR2

	ACE Inhibitor Pathway
	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs

5/7 Reactome Pathways for AGTR2 (see all 7)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Signal Transduction
	Signaling by GPCR
	G alpha (i) signalling events

2 PharmGKB Pathways for AGTR2

	ACE Inhibitor Pathway, Pharmacodynamics
	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

2 Kegg Pathways (Kegg details for AGTR2):

	Neuroactive ligand-receptor interaction
	Renin-angiotensin system

AGTR2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for AGTR2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/156 Interacting proteins for AGTR2 (P50052^{1, 3} ENSP00000360973⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 156)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TIMP3	P35625¹^,³, ENSP00000266085⁴	EBI-1748067,EBI-1748085 I2D: score=1 STRING: ENSP00000266085
AGT	P01019³, ENSP00000355627⁴	I2D: score=2 STRING: ENSP00000355627
ACE	P12821³, ENSP00000290866⁴	I2D: score=1 STRING: ENSP00000290866
AGTRAP	Q6RW13³, ENSP00000319713⁴	I2D: score=1 STRING: ENSP00000319713
PIK3CB	P42338³, ENSP00000289153⁴	I2D: score=1 STRING: ENSP00000289153

About this table

Gene Ontology (GO): 5/41 biological process terms (GO ID links to tree view) (see all 41): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001974	blood vessel remodeling	TAS	17159080
GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	ISS	--
GO:0002018	renin-angiotensin regulation of aldosterone production	IEA	--
GO:0002033	vasodilation by angiotensin involved in regulation of systemic arterial blood pressure	IEA	--
GO:0002035	brain renin-angiotensin system	IEA	--

AGTR2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

AGTR2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for AGTR2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Angiotensin (1-7)	Vasorelaxant peptide	[51833-78-4]
CGP 42112	Selective, high affinity AT2 ligand	[127060-75-7]
PD 123319 ditrifluoroacetate	Potent, selective non-peptide AT2 antagonist	[130663-39-7]
Saralasin	Non-selective angiotensin II antagonist	[34273-10-4]
Angiotensin II	Potent vasoconstrictor peptide	[68521-88-0]

1 HMDB Compound for AGTR2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Angiotensin II	Hypertensin (see all 11)	11128-99-7	--

1 DrugBank Compound for AGTR2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Tasosartan	--	145733-36-4	target	antagonist	11683476

10/41 Novoseek chemical compound relationships for AGTR2 gene (see all 41) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cgp42112a	92.7	14	8920914 (2), 7957644 (2), 7484433 (1), 9239679 (1) (see all 10)
pd123319	92.2	28	7957644 (2), 9918526 (1), 10419063 (1), 8920914 (1) (see all 23)
losartan	83.8	50	11801934 (2), 7957644 (2), 8821748 (2), 9918526 (1) (see all 39)
ang ii	81.4	29	9888501 (3), 12826071 (2), 16112405 (2), 10405785 (2) (see all 18)
etoperidone	71.4	2	15960425 (2)
irbesartan	59.5	7	14506547 (2), 15037537 (1), 15277414 (1), 17877649 (1) (see all 5)
telmisartan	55	1	16372586 (1)
valsartan	54.2	2	14506547 (2)
candesartan	49.9	2	11030714 (1), 10903218 (1)
phosphotyrosine	40.9	4	7749365 (1), 7484433 (1), 7713098 (1), 7829501 (1)

Search CenterWatch for drugs/clinical trials and news about AGTR2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AGTR2 gene:

NM_000686.4

Unigene Cluster for AGTR2:

Angiotensin II receptor, type 2

Hs.405348 [show with all ESTs]

Unigene Representative Sequence: NM_000686

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000371906(uc004eqh.4)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AGTR2
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate AGTR2:
		hsa-miR-539 hsa-miR-3074-3p hsa-miR-548t hsa-miR-3919 hsa-miR-330-3p hsa-miR-3145-3p hsa-miR-1299 hsa-miR-384

		SwitchGear 3'UTR luciferase reporter plasmid: AGTR2 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: AGTR2 (NM_000686)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGTR2

Additional cDNA sequence:

AK313927.1 BC095504.1 CR541969.1 U16957.1 X87723.1

2 DOTS entries:

DT.110560 DT.101965973

24/26 AceView cDNA sequences (see all 26):

CR541969 AI911273 CO247783 CO247675 CO249038 CF147787 CO248117 U16957

NM_000686 X87723 CO248442 CO249037 BV183222 CO249271 CO248200 AA089494

AI392646 CO246596 AA780321 AW514178 N84440 BE825708 AA347561 AL036903

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AGTR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

AGTR2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Cervical Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Sacral Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Thoracic Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Kidney

Metanephric Mesenchyme

Metanephric Mesenchyme Cells

Kidney

Cartilage

Lumbar Intervertebral Disc

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Sclerotome cells (Primary Cell)

Bone, Cartilage, Somite

Beating cell clusters (Spontaneous differen...)

See AGTR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AGTR2

SOURCE GeneReport for Unigene cluster: Hs.405348

UniProtKB/Swiss-Prot: AGTR2_HUMAN, P50052

Tissue specificity: In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube.

Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine

SABiosciences Expression via Pathway-Focused PCR Arrays including AGTR2:

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Hypertension in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGTR2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for AGTR2 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	AGTR2¹	angiotensin II receptor, type 2	62.62(n) 53.04(a)		428708 XM_426266.3 XP_426266.2
lizard (Anolis carolinensis)	Reptilia	AGTR2⁶	--	49(a)	1 ↔ 1	GL343403.1(515403-516485)
zebrafish (Danio rerio)	Actinopterygii	agtr2¹	angiotensin II receptor, type 2	53.78(n) 46.01(a)		503772 NM_001013350.1 NP_001013368.1

ENSEMBL Gene Tree for AGTR2 (if available)
TreeFam Gene Tree for AGTR2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for AGTR2 gene

RXFP3² BDKRB1² AGTR1² GPR25² CXCR7² APLNR² BDKRB2² GPR15²

RXFP4² GPR182²

18/48 SIMAP similar genes for AGTR2 using alignment to 1 protein entry: AGTR2_HUMAN(see all similar genes):

ATGR2 AGTR1 CCR2 CCR4 CXCR2 IL8RB

LPAR6 P2RY5 CCR8 BDKRB2 CCR1 CMKLR1

CYSLTR2 DKFZp686O088 GPR1 KPG_011 LPAR4 OPRK1

AGTR2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121917811^1,2	C	pathogenic	105608919(+)	`TTCCAA/GTTACT`	2	I V	mis¹		0	--	--	--	--
rs35474657^1,2	C,F,	pathogenic	105608957(-)	`GGAACC/TGGTTT`	2	Q R	mis¹		4		NA	4618
rs121917813^1,2	C	pathogenic	105609771(+)	`ACTACA/TTTATA`	2	I F	mis¹		0	--	--	--	--
rs121917810^1,2	C,F,	pathogenic	105609866(+)	`CTTCGG/TGCTTG`	2	G V	mis¹		1		NA	4538
rs17237750^1,2	C,	--	104837385(+)	`CCTGCC/ACTCAT`	1	--	us2k¹		3		NS CSA	131
rs17237757^1,2	C,F,	--	104837770(+)	`AACAGC/TGTGAG`	1	--	us2k¹		3		NS	222
rs13306158^1,2	C,	--	104838875(+)	`TTGCAG/CACAAA`	1	--	us2k¹ tfbs³		1		NA	2
rs17231401^1,2	C,F,	--	104839466(+)	`TGTATG/ACTTAT`	1	--	int¹		3		NS	236
rs17231408^1,2	C,F	--	104839647(+)	`CATTTC/GTCATT`	1	--	int¹		3		NS	236
rs17231415^1,2	C,F,	--	104839924(+)	`ATTCCC/TCATCA`	1	--	int¹		2		NS	142

HapMap Linkage Disequilibrium report for AGTR2 (115301958 - 115306225 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for AGTR2
1 CNV: 3269
1 Indel: 33486
Human Gene Mutation Database (HGMD): AGTR2

Locus Specific Mutation Databases (LSDB): AGTR2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AGTR2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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AGTR2 for disorders About GeneDecksing

OMIM gene information: 300034 OMIM disorders: --

UniProtKB/Swiss-Prot: AGTR2_HUMAN, P50052

Defects in AGTR2 are the cause of mental retardation X-linked type 88 (MRX88) [MIM:300852]. Mental retardation

is characterized by significantly below average general intellectual functioning associated with impairments in

adaptative behavior and manifested during the developmental period

20/68 diseases for AGTR2 (see all 68): About MalaCards

mental retardation, x-linked open-angle glaucoma end stage renal failure vesicoureteral reflux

pre-eclampsia renal agenesis myocardial infarction congestive heart failure

myocardial stunning hydronephrosis premature ovarian failure cerebrovascular accident

ureteral obstruction cushing's syndrome essential hypertension conn's syndrome

angioedema acute myocardial infarction intellectual disability coronary heart disease

10/54 Novoseek disease relationships for AGTR2 gene (see all 54) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
diabetic nephropathies	52.2	3	14632698 (1), 16780569 (1), 18454253 (1)
cardiac hypertrophy	51.5	1	11751703 (1)
ventricular hypertrophy	49.4	7	20467270 (2), 17944121 (1), 17319472 (1), 17620959 (1) (see all 6)
renal disease	48.5	15	15756705 (1), 16372586 (1), 19404281 (1), 15153562 (1) (see all 11)
hypertrophy	46.1	3	16286564 (2), 11728881 (1)
cardiovascular diseases	39.7	7	9449684 (1), 19861349 (1), 8773261 (1), 14707017 (1) (see all 6)
heart failure	37.7	7	8957548 (1), 10361430 (1), 9054850 (1), 10727655 (1) (see all 5)
pheochromocytoma	32.4	4	7484433 (1), 10361432 (1), 7713098 (1), 18296263 (1)
nephropathy obstructive	32.2	1	16133060 (1)
myocardial infarction	31.2	9	14506547 (4), 10361430 (1), 11224700 (1), 14632698 (1) (see all 5)

Genetic Association Database (GAD): AGTR2
Human Genome Epidemiology (HuGE) Navigator: AGTR2 (104 documents)

Export disorders for AGTR2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for AGTR2 gene, integrated from 9 sources (see all 419):
(articles sorted by number of sources associating them with AGTR2)

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Angiotensin II type 2 receptor gene is not responsible for familial vesicoureteral reflux. (PubMed id 12187255)^{1, 4, 9} Yoneda A....Puri P. (2002)
Implication of genetic variations in congenital obstructive nephropathy. (PubMed id 16133060)^{1, 4, 9} Hahn H....Cheong H.I. (2005)
Angiotensin II type 2 receptor gene polymorphism and cardiovascular phenotypes: the GLAECO and GLAOLD studies. (PubMed id 12453540)^{1, 4, 9} Herrmann S.M....Regitz-Zagrosek V. (2002)
[Relation between the angiotensin II type 2 receptor polymorphism and essential hypertension in men] (PubMed id 16080803)^{1, 4, 9} Qiao W.W....Xu S.J. (2005)
Angiotensin gene polymorphism as a determinant of posttransplantation renal dysfunction and hypertension. (PubMed id 11544438)^{1, 4, 9} Abdi R....Milford E.L. (2001)
Angiotensin II type 2 receptor gene polymorphisms and essential hypertension. (PubMed id 14627490)^{1, 4, 9} Zhang Y....Zhu D.L. (2003)
Molecular cloning of the human angiotensin II type 2 receptor cDNA. (PubMed id 7999093)^{1, 2, 9} Martin M.M.... Elton T.S. (1994)
Angiotensin-converting enzyme gene polymorphism significantly affects renal posttransplantation erythrocytosis. (PubMed id 15013333)^{1, 4, 9} Micozkadioglu H....Haberal M. (2004)
Angiotensin-converting enzyme and angiotensin type 2 receptor gene genotype distributions in Italian children with congenital uropathies. (PubMed id 15470205)^{1, 4, 9} Rigoli L....Salpietro C.D. (2004)
Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP. (PubMed id 15123706)^{1, 2, 9} Nouet S.... Nahmias C. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 186	HGNC: 338	AceView: AGTR2	Ensembl:ENSG00000180772	euGenes: HUgn186
ECgene: AGTR2	Kegg: 186	H-InvDB: AGTR2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for AGTR2	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/AGTR2

Intellectual Property for AGTR2 gene
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Patent Information for AGTR2 gene:
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GeneCards and IP:
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angiotensin II receptor, type 2

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Hydronephrosis
Microalbuminuria
HYPERTENSION ARTERIAL
essential hypertension
Hyperplasia
Aldosteronism Primary
Carcinoma
INFARCT
Angioedema
Alzheimers Disease
Myocardial Ischemia
Ischemia
Atherosclerosis
Ventricular Dysfunction Left
Breast Cancer
neurodegeneration
Ovarian Failure Premature
systemic hypertension
Vesicoureteral Reflux
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Multicystic Dysplastic Kidney
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benign prostatic hyperplasia
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AGTR2 Gene

angiotensin II receptor, type 2

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