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AGTR1 Gene

protein-coding GIFtS: 68

GC03P149898

angiotensin II receptor, type 1
(Previous name: angiotensin receptor 1B )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: AGTR1B)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
AG2S ^¹, ²
AGTR1A ^¹, ², ³, ⁵
AGTR1B ^², ³
AT1 ^¹, ², ³
AT1AR ^³
AT1B ^¹, ²
AT1BR ^³
AT1R ^²
AT2R1 ^¹, ², ³, ⁵
AT2R1A ^¹, ²
AT2R1B ^¹, ², ³
HAT1R ^¹, ²

Descriptions
angiotensin II receptor, type 1 ^²
angiotensin receptor 1 ^²
angiotensin receptor 1B ^¹, ²
type-1B angiotensin II receptor ^²

External Ids
HGNC: 336¹
Entrez Gene: 185²
UniProtKB: P30556³
Ensembl: ENSG00000144891⁷

Search outside databases for aliases for AGTR1 gene

Previous GC identifers: GC03P145407 GC03P149300 GC03P149697 GC03P149736

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AGTR1:

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It

is an important effector controlling blood pressure and volume in the cardiovascular system. It

acts through at least two types of receptors. This gene encodes the type 1 receptor which is

thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role

in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or

infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed;

however, it is now believed that there is only one type 1 receptor gene in humans. At least five

transcript variants have been described for this gene. Additional variants have been described but

their full-length nature has not been determined. The entire coding sequence is contained in the

terminal exon and is present in all transcript variants. [provided by RefSeq]

UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556

Function: Receptor for angiotensin II. Mediates its action by association with G proteins that

activate a phosphatidylinositol-calcium second messenger system

Gene Wiki entry for AGTR1 (Angiotensin_II_receptor_type_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AGTR1 gene

Entrez Gene cytogenetic band: 3q21-q25 Ensembl cytogenetic band: 3q24 HGNC cytogenetic band: 3q21-q25

AGTR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P149898: (about GC identifiers)

Start:	149,898,348 bp from pter
End:	149,943,480 bp from pter
Size:	45,133 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556 (See protein sequence)

Recommended Name: Type-1 angiotensin II receptor

Size: 359 amino acids; 41061 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

1ZV0 (3D)

Secondary accessions: Q13725

Post-translational modifications:

C-terminal Ser or Thr residues may be phosphorylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (5 alternative transcripts):

NP_000676.1 NP_004826.2 NP_033611.1 NP_114038.1 NP_114438.1

ENSEMBL proteins:

ENSP00000385641 ENSP00000385612 ENSP00000384447 ENSP00000273430 ENSP00000384643

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant AGTR1 Protein
	Sigma-Aldrich Proteins for AGTR1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Angiotensin II Type 1 Receptor)
	Human Recombinant Proteins from Abnova (AGTR1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	1378723

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Antibodies for AGTR1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of AGTR1
	Sigma-Aldrich Antibodies for AGTR1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Angiotensin II Type 1 Receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AGTR1)
	Novus Biologicals Antibody for AGTR1

Assays for AGTR1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P30556

ProtoNet protein and cluster: P30556

2 Blocks protein families:

IPB000190 AT1 angiotensin II receptor signature

IPB000248 Angiotensin II receptor signature

UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AGTR1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AGTR1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_031850

Applied Biosystems Silencer® siRNAs for AGTR1

Sigma-Aldrich siRNA and siRNA Panels for AGTR1

Sigma-Aldrich shRNA Panels and shRNA for AGTR1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AGTR1
		Millipore Clones for the Expression of AGTR1

OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_000685
Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_000685
untagged cDNA clones in CMV expression vector (see all 6): NM_000685

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_032049

UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556

Function: Receptor for angiotensin II. Mediates its action by association with G proteins that

activate a phosphatidylinositol-calcium second messenger system

Genatlas biochemistry entry for AGTR1:

angiotensin II (type-1) receptor,G protein coupled receptor superfamily,including two subtypes AT1A

and AT1B,major blood pressure regulator (activation of vascular growth),inhibiting adenylate

cyclase,activating phospholipase C and A2,contributing in association with ACE to the risk of

coronary disease,localized in the substantia nigra, the caudate nucleus and putamen

(neuromodulator),blood vessels ,heart (conduction system) and kidney (renal medullary interstitial

cells)

7 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Agtr1a):

	behavior/neurological	growth/size	hematopoietic system	homeostasis/metabolism
lethality-postnatal	renal/urinary system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001596	angiotensin type I receptor activity	IPI	1378723
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004945	angiotensin type II receptor activity	NAS	8135787
GO:0010698	acetyltransferase activator activity	IMP	18971559

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for AGTR1 (Your Favorite Gene powered by Ingenuity)

Hepatic Fibrosis / Hepatic Stellate Cell Activation
G-Protein Coupled Receptor Signaling
cAMP-mediated Signaling
Renin-Angiotensin Signaling

GeneDecks AGTR1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for AGTR1

5/43 Interacting proteins for AGTR1 (ENSP00000273430³ P30556²) via UniProtKB, MINT, and/or STRING (see all 43 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARRB1	P49407²	MINT-4791905
AGT	ENSP00000355627³	STRING (score=.999)
GNAQ	ENSP00000286548³	STRING (score=.986)
REN	ENSP00000272190³	STRING (score=.985)
ACE	ENSP00000290866³	STRING (score=.967)

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5/19 Gene Ontology (GO) biological process terms (links to tree view) (see all 19 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	NAS	17159080
GO:0001822	kidney development	IMP	16116425
GO:0002018	renin-angiotensin regulation of aldosterone production	NAS	17159080
GO:0002034	regulation of blood vessel size by renin-angiotensin	IC	10993080
GO:0003078	regulation of natriuresis	NAS	17159080

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for AGTR1:

Antagonist Agonist Inhibitor

Compounds for AGTR1 available from Tocris Bioscience

Compound	Action	CAS number
ZD 7155 hydrochloride	Selective non-peptide AT1 antagonist	[146709-78-6]
Saralasin	Non-selective angiotensin II antagonist	[34273-10-4]
Anti-AT1	Antibody recognizing AT1
Angiotensin II	Potent vasoconstrictor peptide	[68521-88-0]

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10/49 Novoseek chemical compound relationships for AGTR1 gene (see all 49 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cgp42112a	83.15	15	8675601 (2), 8243303 (2), 10696069 (1), 9239679 (1) (see all 10)
etoperidone	63.02	1	15960425 (1)
aliskiren	59.73	2	16979787 (1), 16914963 (1)
temocaprilat	56.34	2	12733700 (1), 12239236 (1)
sodium	50.19	17	16320974 (2), 8777826 (1), 11521525 (1), 16198010 (1) (see all 14)
nitric oxide	48.87	62	10678543 (3), 11103753 (3), 16923758 (2), 15848528 (2) (see all 49)
calcium	45.91	94	12807644 (3), 12023270 (3), 12807566 (3), 8877782 (3) (see all 64)
nadph	37.98	12	12426214 (2), 12514663 (1), 17665974 (1), 15976327 (1) (see all 10)
tyrosine	33.01	28	8613189 (2), 8569717 (1), 9556076 (1), 9918526 (1) (see all 26)
potassium	23.57	5	15342638 (2), 7768552 (1), 17725712 (1), 17449550 (1)

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2 PharmGKB drug compound relationships for AGTR1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
losartan	PK GN	11966404
perindopril	PD	8952600

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AGTR1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AGTR1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_031850

Sigma-Aldrich siRNA and siRNA Panels for AGTR1

Sigma-Aldrich shRNA Panels and shRNA for AGTR1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000685 NM_004835 NM_009585 NM_031850 NM_032049

REFSEQ mRNAs for AGTR1 gene (5 alternative transcripts):

NM_000685.4 NM_004835.3 NM_009585.3 NM_031850.2 NM_032049.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000685 NM_004835 NM_009585 NM_031850 NM_032049

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_000685
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_000685
                                 untagged cDNA clones in CMV expression vector (see all 6): NM_000685

Additional cDNA sequence: M87290.1

11 DOTS entries:

DT.91753556 DT.100793614 DT.100035887 DT.100035892 DT.100737728 DT.100793608 DT.91753566 DT.95162616

DT.100793625 DT.65284361 DT.99966243

24/110 AceView cDNA sequences (see all 110 ):

AA470024 BU150328 AU136693 CR600504 CR601313 CR593142 BX369311 AV646533

AV646497 CA436042 BF109945 AL572581 T28644 BC068494 AI373895 BV183221

AL542674 BC022447 BX089691 AI911517 NM_004835 CD013886 CD013885 BE501493

highest scoring ESTs for AGTR1:

D13814 S77410 AA412302 AA442719 AA470024 AI016286 AI240900 AI373895 AI378001 AI768584

Unigene Clusters for AGTR1:

Angiotensin II receptor, type 1

Hs.477887 [show with all ESTs], Hs.719071 [show with all ESTs]

Unigene Representative Sequences: NM_031850, M87290

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for AGTR1

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c
SP1:							-		-		-		-
SP2:
SP3:													-
SP4:					-		-		-		-		-
SP5:													-

About this scheme

ECgene alternative splicing isoforms for AGTR1

5 Ensembl transcripts including schematic representations:

ENST00000402260 ENST00000404754 ENST00000407012 ENST00000349243 ENST00000406061

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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AGTR1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AGTR1

¹ / ² / ³

6 probe-sets matching AGTR1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
346_s_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.88	D13814	1.00	1.00	1.00	1
37983_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.13	S77410	1.00	1.00	1.00	1
205357_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000685	0.60	1.00	0.82	1
208016_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004835	0.60	1.00	0.82	1
205357_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208016_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks AGTR1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.477887 Hs.719071
Expression variation in blood from EXPOLDB for AGTR1
UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556
Tissue specificity: Liver, lung, adrenal and adrenocortical adenomas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for AGTR1 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	AGTR1¹	--	angiotensin II receptor, type 1	99.72(n) 99.72(a)	460762 XM_001136214.1 XP_001136214.1
cow (Bos taurus)	AGTR1¹	--	angiotensin II receptor, type 1	91.18(n) 95.26(a)	281607 NM_174233.2 NP_776658.1
rat (Rattus norvegicus)	Agtr1¹	--	angiotensin II receptor, type 1	86.35(n) 94.71(a)	24180 NM_030985.3 NP_112247.2
mouse (Mus musculus)	Agtr1a^{1, 5}	13 (16.00 cM)⁵	angiotensin II receptor, type 1a^{1, 5}	87(n)¹ 94.43(a)¹	11607¹ NM_177322.2¹ NP_796296.1¹ AI551199⁵ AI593508⁵ (see all 9)
chicken (Gallus gallus)	AGTR1¹	--	angiotensin II receptor, type 1	73.82(n) 75.77(a)	396065 NM_205157.2 NP_990488.1

About this table Species with no ortholog for AGTR1

ENSEMBL Gene Tree for AGTR1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for AGTR1 gene

BDKRB1² APLNR² BDKRB2² AGTR2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/601 NCBI SNPs in AGTR1 are shown (see all 601 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 200)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs389566^1,2	A,C,F,H,O	149929072(+)	`GATCCA/TGAAAT`	5	--	ng5¹ int¹		17	EA NS NA EU WA	2274
--	rs422858^1,2	A,C,F,H	149898174(-)	`TCACGCT/G /GG/TGGTCC`	4	--	ng5¹		4	EU EA WA	418
	rs275651^1,2	A,C,F,H	149897577(-)	`atgttA/Tgatag`	4	--	ng5¹		10	EU EA WA NS	912
	rs275652^1,2	A,C,F,H	149897674(-)	`aattgA/Catcca`	4	--	ng5¹		11	EU EA WA NS	1872
	rs12695901^1,2	C,F,H	149930303(+)	`GCTGGC/TGAAAC`	5	--	int¹ ng5¹		5	NS EU EA WA	460
--	rs12721226^1,2	C,F,H	149941999(+)	`TGCCAG/ACTATA`	5	T/A	mis¹		5	NS EU EA WA	452
--	rs275650^1,2	A,C,F	149897249(-)	`ATAAAT/ATTAAA`	4	--	ng5¹ tfbs³		2	NS	94
	rs12721256^1,2	C,F,H	149930124(+)	`GGCATC/TGGTGT`	5	--	int¹ ng5¹		5	NS EU EA WA	464
--	rs12721225^1,2	C,F,H	149942242(+)	`TTATGG/TCAATT`	5	A/S	mis¹ ese³		5	NS EU EA WA	450
	rs388915^1,2	A,C,F	149930446(+)	`TGCTCA/GCAGGG`	5	--	int¹ ng5¹		7	MN EA NS NA	1900

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HapMap Linkage Disequilibrium images for AGTR1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 106165 disorders: 145500 267430

UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556

Defects in AGTR1 are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an

autosomal recessive severe disorder of renal tubular development characterized by persistent fetal

anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios

(the Potter phenotype)

10/96 Novoseek disease relationships for AGTR1 gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
essential hypertension	76.87	62	8021009 (2), 9544872 (2), 10082497 (2), 11793845 (2) (see all 48)
diabetic nephropathies	72.36	38	12477969 (3), 10907125 (2), 8671962 (2), 11388646 (1) (see all 28)
renal disease	70.49	62	17506717 (4), 11996640 (3), 9741738 (3), 9818206 (3) (see all 43)
cardiovascular diseases	67.59	32	9449684 (2), 9702074 (2), 9740630 (1), 16519598 (1) (see all 29)
ventricular hypertrophy	66.36	22	10351920 (2), 7498879 (2), 15612584 (2), 9601485 (1) (see all 17)
heart failure	66.02	99	9302352 (5), 8872858 (4), 11996651 (4), 10411851 (2) (see all 63)
proteinuria	62.55	24	16923922 (2), 15446600 (2), 17665974 (1), 18497456 (1) (see all 20)
cardiac hypertrophy	61.40	24	9741738 (3), 10750587 (1), 10820928 (1), 11692158 (1) (see all 15)
hypertrophy	59.71	22	14985364 (2), 19074594 (1), 8987966 (1), 10989742 (1) (see all 21)
atherosclerosis	58.66	18	15998704 (1), 18475152 (1), 19275607 (1), 9702074 (1) (see all 16)

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2 PharmGKB disease relationships for AGTR1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Hypertension	PD PK GN	11966404 8952600
Myocardial Infarction	CO GN	15454732

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Genatlas disease: AGTR1

Bartter syndrome characterized by hypokalemic alkalosis,normal or hypercalciuria,normal

magnesemia,early onset and hyperreninemia,hyperaldosteronism,hyperplasia of the juxtaglomerular

apparatus

Human Gene Mutation Database: AGTR1
Genetic Association Database: AGTR1
Human Genome Epidemiology Navigator: AGTR1 (333 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1316 PubMed articles for AGTR1 gene (see all 1316 ):

Angiotensin II type I receptor gene and myocardial infarction: tagging SNPs and haplotype based association study. The Beijing atherosclerosis study. (PubMed id 15454732)^{1, 3, 7} Su S....Gu D. (2004)
Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor. (PubMed id 1550596)^{2, 3, 4} Takayanagi R.... Nawata H. (1992)
Type 1 angiotensin II receptors of adrenal tumors. (PubMed id 7792812)^{1, 3, 4} Nawata H.... Ohe K. (1995)
Multiple Polymorphisms in the renin- angiotensin-aldosterone system (ACE, CYP11B2, AGTR1) and their contribution to hypertension in African Americans and Latinos in the multiethnic cohort. (PubMed id 15545843)^{1, 3, 6} Henderson S.O....Mack W. (2004)
Novel subtype of human angiotensin II type 1 receptor: cDNA cloning and expression. (PubMed id 8135787)^{1, 3, 4} Konishi H.... Fujisawa Y. (1994)
1166C mutation of angiotensin II type 1 receptor gene is correlated with umbilical blood flow velocimetry in women with preeclampsia. (PubMed id 16076618)^{1, 3, 6} Seremak-Mrozikiewicz A....Mrozikiewicz P.M. (2005)
[ACE and AGTR1 genes polymorphisms in left ventricular hypertrophy pathogenesis in humans] (PubMed id 15612584)^{1, 3, 6} Makeeva O.A....Puzyrev V.P. (2004)
Endothelial nitric oxide synthase and angiotensin II type 1 receptor gene polymorphisms can influence chronic inflammatory state in renal transplant patients. (PubMed id 15848528)^{1, 3, 6} Sezer S....Haberal M. (2005)
[Polymorphic markers of GNB3 (C825T), AGTR1 (A1166C) and ACE (A2350G and I/D) genes in patients with arterial hypertension combined with diabetes mellitus type 2] (PubMed id 15332573)^{1, 3, 6} Karpov R.S....Atroshenkov A.V. (2004)
A chymase gene variant is associated with atherosclerosis in venous coronary artery bypass grafts. (PubMed id 11696688)^{1, 3, 6} Ortlepp J.R....Hoffmann R. (2001)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 185	HGNC: 336	AceView: AGTR1	Ensembl:ENSG00000144891	euGenes: HUgn185
ECgene: AGTR1	H-InvDB: AGTR1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.genetests.org/query?gene=AGTR1
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=AGTR1
Wikipedia	http://en.wikipedia.org/wiki/Angiotensin_receptor

Licensable Technologies for AGTR1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for AGTR1:

TaqMan ® Gene Expression Assays

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Antibodies for AGTR1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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AGTR1 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for AGTR1

Summaries
for AGTR1

Genomic Location
for AGTR1

Proteins
for AGTR1

Protein Domains/
Families
for AGTR1

Gene Function
for AGTR1

Pathways & Interactions
for AGTR1

Drugs & Compounds
for AGTR1

Transcripts
for AGTR1

Expression
for AGTR1

Orthologs
for AGTR1

Paralogs
for AGTR1

SNPs/Variants
for AGTR1

Disorders & Mutations
for AGTR1

Medical News
for AGTR1

Publications
for AGTR1

Search for AGTR1

Genome Databases showing AGTR1

Other Databases showing AGTR1

Specialized Databases showing AGTR1

Licensable Technologies
for AGTR1

Services
for AGTR1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AGTR1 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor AGTR1

Summariesfor AGTR1

Genomic Locationfor AGTR1

Proteinsfor AGTR1

Protein Domains/Familiesfor AGTR1

Gene Functionfor AGTR1

Pathways & Interactionsfor AGTR1

Drugs & Compoundsfor AGTR1

Transcriptsfor AGTR1

Expression for AGTR1

Orthologsfor AGTR1

Paralogsfor AGTR1

SNPs/Variantsfor AGTR1

Disorders & Mutationsfor AGTR1

Medical Newsfor AGTR1

Publicationsfor AGTR1

Search for AGTR1

Genome Databases showing AGTR1

Other Databases showing AGTR1

Specialized Databases showing AGTR1

Licensable Technologiesfor AGTR1

Servicesfor AGTR1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AGTR1

Summaries
for AGTR1

Genomic Location
for AGTR1

Proteins
for AGTR1

Protein Domains/
Families
for AGTR1

Gene Function
for AGTR1

Pathways & Interactions
for AGTR1

Drugs & Compounds
for AGTR1

Transcripts
for AGTR1

Expression
for AGTR1

Orthologs
for AGTR1

Paralogs
for AGTR1

SNPs/Variants
for AGTR1

Disorders & Mutations
for AGTR1

Medical News
for AGTR1

Publications
for AGTR1

Licensable Technologies
for AGTR1

Services
for AGTR1