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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AGTR1 Gene

protein-coding GIFtS: 72
GCID: GC03P148415

angiotensin II receptor, type 1

(Previous name: angiotensin receptor 1B )
(Previous symbol: AGTR1B)

Explore 189 diseases affiliated with
AGTR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Angiotensin II Receptor, Type 1¹ ²		HAT1R¹ ²
AGTR1A¹ ² ³ ⁵		AT1AR² ³
AT2R1¹ ² ³ ⁵		AT1BR² ³
AGTR1B¹ ² ³		Angiotensin Receptor 1B¹
AT1¹ ² ³		AT1R²
AT2R1B¹ ² ³		Type-1 Angiotensin II Receptor²
AG2S¹ ²		Type-1B Angiotensin II Receptor²
AT1B¹ ²		Angiotensin II Type-1 Receptor³
AT2R1A¹ ²

External Ids:	HGNC: 336¹	Entrez Gene: 185²	Ensembl: ENSG00000144891⁷	OMIM: 106165⁵	UniProtKB: P30556³

Export aliases for AGTR1 gene to outside databases

Previous GC identifers: GC03P145407 GC03P149300 GC03P149697 GC03P149736 GC03P149898 GC03P145788

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AGTR1:

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important

effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of

receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of

angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood

flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed;

however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced

transcript variants have been reported for this gene. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556

Function: Receptor for angiotensin II. Mediates its action by association with G proteins that activate a

phosphatidylinositol-calcium second messenger system

summary for AGTR1:

The angiotensin1 receptors (AT1) is a member of the angiotensin group of G-protein-coupled receptors that

also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung where

they play a role in vasoconstriction, aldosterone and vasopressin release, salt and water retention, cell

proliferation and migration and sympathetic stimulation. Most species express a single AT1 gene, but two

related genes AT1A and AT1B are found in rodents. The human AT1 receptor gene has been localized to

chromosome 3 (3q21-q25).

Gene Wiki entry for AGTR1 (Angiotensin II receptor type 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AGTR1 gene promoter:
AP-2alpha isoform 3 AP-2alpha isoform 2 AP-2alpha AP-2alphaA
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for AGTR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGTR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24 Ensembl cytogenetic band: 3q24 HGNC cytogenetic band: 3q24

AGTR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGTR1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P148415: view genomic region (about GC identifiers)

Start:	148,415,571 bp from pter	End:	148,460,795 bp from pter
Size:	45,225 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556 (See protein sequence)

Recommended Name: Type-1 angiotensin II receptor

Size: 359 amino acids; 41061 Da

Subunit: Interacts with MAS1 (Probable). Interacts with ARRB1 (By similarity)

Subcellular location: Cell membrane; Multi-pass membrane protein

1 PDB 3D structure from and Proteopedia for AGTR1:

1ZV0 (3D)

Secondary accessions: Q13725

Explore the universe of human proteins at neXtProt for AGTR1: NX_P30556

Post-translational modifications:

C-terminal Ser or Thr residues may be phosphorylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P30556

AGTR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_000676.1 NP_004826.5 NP_033611.1 NP_114038.4 NP_114438.2

ENSEMBL proteins:

ENSP00000419422 ENSP00000273430 ENSP00000385612 ENSP00000419783 ENSP00000418084

ENSP00000418851 ENSP00000443186 ENSP00000398832 ENSP00000385641

Reactome Protein details: P30556
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant AGTR1 Protein
	Browse R&D Systems for human recombinant proteins
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	Novus Biologicals AGTR1 Proteins Novus Biologicals AGTR1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for AGTR1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	IC	1378723
GO:0016021	integral to membrane	NAS	8135787

AGTR1 for ontologies About GeneDecksing

AGTR1 Antibody Products:

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	ThermoFisher Antibody for AGTR1

Assay Products for AGTR1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript AGTR1-overexpressing Cell Line for Assay
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for AGTR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AGTR1 for domains About GeneDecksing

4 InterPro domains/families:

IPR000190 ATII_AT1_rcpt

IPR017452 GPCR_Rhodpsn_7TM

IPR000276 GPCR_Rhodpsn

IPR000248 ATII_rcpt

Graphical View of Domain Structure for InterPro Entry P30556

ProtoNet protein and cluster: P30556

2 Blocks protein families:

IPB000190 AT1 angiotensin II receptor signature

IPB000248 Angiotensin II receptor signature

UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556

Function: Receptor for angiotensin II. Mediates its action by association with G proteins that activate a

phosphatidylinositol-calcium second messenger system

Genatlas biochemistry entry for AGTR1:

angiotensin II (type-1) receptor,G protein coupled receptor superfamily,including two subtypes AT1A and AT1B,major

blood pressure regulator (activation of vascular growth),inhibiting adenylate cyclase,activating phospholipase C and

A2,contributing in association with ACE to the risk of coronary disease,localized in the substantia nigra, the caudate

nucleus and putamen (neuromodulator),blood vessels ,heart (conduction system) and kidney (renal medullary interstitial

cells)

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		OriGene 3'-UTR Clone (see all 5): AGTR1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AGTR1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate AGTR1:
		hsa-miR-4330
		SwitchGear 3'UTR luciferase reporter plasmid: AGTR1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for AGTR1

Clone Products:		EMD Millipore Clones for the Expression of AGTR1
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		GenScript: all cDNA clones in your preferred vector (see all 5): AGTR1 (NM_000685)
		Sino Biological Human cDNA Clone for AGTR1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGTR1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGTR1

Cell Line Products:		GenScript AGTR1-overexpressing Cell Line for Assay
		Search LifeMap BioReagents cell lines for AGTR1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGTR1

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001596	angiotensin type I receptor activity	IPI	1378723
GO:0004945	angiotensin type II receptor activity	IDA	1567413
GO:0005515	protein binding	IPI	15611106
GO:0010698	acetyltransferase activator activity	IMP	18971559
GO:0031711	bradykinin receptor binding	IPI	10993080

AGTR1 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for AGTR1:

Decreased substrate adherent c

Increased gamma-H2AX phosphory

Synthetic lethal with Ras

Animal Models:
Mouse knock-out Agtr1b^tm1Cof for AGTR1
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Agtr1b):

cardiovascular system	growth/size	homeostasis/metabolism	immune system	mortality/aging
renal/urinary system

AGTR1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	GPCRs, Class A Rhodopsin-like	0.41
GPCR ligand binding	0.75	Neuroactive ligand-receptor interaction	0.38
Peptide ligand-binding receptors	0.61

Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics	1.00			ACE Inhibitor Pathway	0.85
	ACE Inhibitor Pathway, Pharmacodynamics	1.00

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Cell adhesion_Integrin inside-out signaling

Cell adhesion_Integrin inside-out signaling

1.00

Cell adhesion Integrin inside-out signaling

0.99

Development Angiotensin activation of ERK

Development Angiotensin activation of ERK

1.00

Development_Angiotensin activation of ERK

0.98

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for AGTR1

	Development Angiotensin signaling via PYK2
	Development Angiotensin signaling via beta-Arrestin
	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
	Cell adhesion Integrin inside-out signaling
	Development Angiotensin activation of ERK

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AGTR1

	Renin-Angiotensin Pathway
	JAK-STAT Pathway

4 GeneGo (Thomson Reuters) Pathways for AGTR1

	Development Angiotensin activation of ERK
	Development Angiotensin signaling via beta-Arrestin
	Cell adhesion Integrin inside-out signaling
	Development Angiotensin signaling via PYK2

5 BioSystems Pathways for AGTR1

	ACE Inhibitor Pathway
	GPCRs, Class A Rhodopsin-like
	Arf6 signaling events
	Angiopoietin receptor Tie2-mediated signaling
	Peptide GPCRs

5/8 Reactome Pathways for AGTR1 (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

3 PharmGKB Pathways for AGTR1

	ACE Inhibitor Pathway, Pharmacodynamics
	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
	Losartan Pathway, Pharmacokinetics

4 Kegg Pathways (Kegg details for AGTR1):

	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Renin-angiotensin system

AGTR1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for AGTR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/149 Interacting proteins for AGTR1 (P30556^{2, 3} ENSP00000273430⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 149)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PLCG1	P19174²^,³, ENSP00000244007⁴	MINT-8029402 I2D: score=2 STRING: ENSP00000244007
GNAQ	P50148²^,³, ENSP00000286548⁴	MINT-4791922 I2D: score=1 STRING: ENSP00000286548
ARRB1	P49407²^,³, ENSP00000377141⁴	MINT-4791905 I2D: score=2 STRING: ENSP00000377141
AGTRAP	Q6RW13³, ENSP00000319713⁴	I2D: score=4 STRING: ENSP00000319713
MAPK1	P28482³, ENSP00000215832⁴	I2D: score=2 STRING: ENSP00000215832

About this table

Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	NAS	17159080
GO:0001822	kidney development	IMP	16116425
GO:0002018	renin-angiotensin regulation of aldosterone production	NAS	17159080
GO:0002034	regulation of blood vessel size by renin-angiotensin	IC	10993080
GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	IC	1378723

AGTR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

AGTR1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for AGTR1 available from Tocris Bioscience About this table

Compound	Action	CAS #
Valsartan	High affinity, selective AT1 antagonist	[137862-53-4]
EMD 66684	Potent, selective non-peptide AT1 antagonist	[187683-79-0]
ZD 7155 hydrochloride	Selective non-peptide AT1 antagonist	[146709-78-6]
Angiotensin II	Potent vasoconstrictor peptide	[68521-88-0]
Losartan potassium	Selective, nonpeptide AT1 antagonist	[124750-99-8]

4 HMDB Compounds for AGTR1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Aldosterone	(+)-Aldosterone (see all 22)	52-39-1	18326554
Angiotensin II	Hypertensin (see all 11)	11128-99-7	--
Bradykinin	Callidin I (see all 5)	58-82-2	--
Calcium	Ca (see all 2)	7440-70-2	--

10 DrugBank Compounds for AGTR1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Telmisartan	BIBR 277 (see all 2)	144701-48-4	target	antagonist	20448797 17691961 18580862 15498586 11444497 15617852 11752352 19147680 11408526 9259062 16938288 10067800 11558835 9878991
Irbesartan	--	138402-11-6	target	antagonist	10822210 11486244 15101793 10082498 14716205 17408613 7843749 11752352 10069682 18627212 15030294 10075381 10373224
Candesartan	--	139481-59-7	target	antagonist	10826401 16601569 19563275 16901636 17588300 10805052 11752352 12504781 19436650 10968199 9892163
Eprosartan	--	133040-01-4	target	antagonist	12927226 10856732 12782193 12184062 12766389 11752352 12517247 11320369 9602957 12540520 18093407
Losartan	DUP 89 (see all 2)	114798-26-4	target	antagonist	15026875 15991937 12710529 11752352 15573751 12719755
Olmesartan	DE-092 (see all 3)	144689-63-4	target	antagonist	16220064 17163232 11451212 12076183 11752352 16775509
Valsartan	--	137862-53-4	target	antagonist	12460705 8242249 15579516 11752352 12023686 8577935
Forasartan	--	145216-43-9	target	antagonist	8981065 11752352 11569611 9156352
Tasosartan	--	145733-36-4	target	antagonist	11046101 11683476 12113820 11752352
Saprisartan	--	146623-69-0	target	antagonist	11752352 10579749

10/140 Novoseek chemical compound relationships for AGTR1 gene (see all 140) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
losartan	93.9	298	7556378 (3), 19487683 (3), 16601194 (2), 9211022 (2) (see all 99)
candesartan	91.9	94	19760950 (2), 16766543 (2), 18854846 (2), 11800413 (2) (see all 74)
valsartan	88.9	58	16206603 (2), 17395057 (2), 19307231 (2), 12688405 (2) (see all 50)
pd123319	88.7	37	9918526 (1), 10419063 (1), 15953595 (1), 8913541 (1) (see all 29)
telmisartan	87.9	48	18158351 (2), 18380932 (2), 20056982 (2), 17122147 (2) (see all 37)
olmesartan	87.1	36	17608670 (2), 11588406 (1), 16148612 (1), 19047580 (1) (see all 31)
irbesartan	86.9	63	14962486 (2), 11791028 (2), 12184030 (2), 11910301 (2) (see all 37)
ang ii	86.7	95	16112405 (4), 17630322 (4), 10467229 (3), 15905175 (3) (see all 56)
cgp42112a	83	16	8675601 (2), 8243303 (2), 10696069 (1), 9239679 (1) (see all 11)
eprosartan	82.7	16	11580885 (2), 12927226 (2), 12359982 (1), 15366789 (1) (see all 13)

1 PharmGKB related drug/compound annotation for AGTR1 gene

Drug/compound	PharmGKB Annotation
perindopril	CA

About this table

Search CenterWatch for drugs/clinical trials and news about AGTR1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AGTR1 gene (5 alternative transcripts):

NM_000685.4 NM_004835.4 NM_009585.3 NM_031850.3 NM_032049.3

Unigene Clusters for AGTR1:

Angiotensin II receptor, type 1

Hs.477887 [show with all ESTs], Hs.740357 [show with all ESTs]

Unigene Representative Sequences: NM_031850, M87290

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000497524(uc003ewj.3) ENST00000349243(uc003ewi.3) ENST00000404754

ENST00000475166 ENST00000475347 ENST00000474935 ENST00000461609 ENST00000542281(uc003ewg.3)

ENST00000418473(uc003ewh.3) ENST00000402260(uc003ewk.3)

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate AGTR1:
		hsa-miR-4330
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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AGTR1 (see all 7) OriGene shRNA RFP: AGTR1 OriGene siRNA: AGTR1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGTR1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGTR1 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGTR1 (see all 6) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): AGTR1 (NM_000685)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGTR1

Additional cDNA sequence: M87290.1

10 DOTS entries:

DT.91753556 DT.100793614 DT.100035887 DT.100035892 DT.100793608 DT.91753566 DT.95162616 DT.100793625

DT.99966243 DT.65284361

24/110 AceView cDNA sequences (see all 110):

CR600504 BU150328 AA470024 CR593142 CR601313 AU136693 BX502128 BX502129

CD013886 AU134810 AA442719 NM_031850 AI768584 AL542674 BX397197 CA436042

AV646533 BX417755 BX106176 AV646497 AL552790 CB989105 BG573153 AL547734

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for AGTR1 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c
SP1:							-		-		-		-
SP2:
SP3:													-
SP4:					-		-		-		-		-
SP5:													-

ECgene alternative splicing isoforms for AGTR1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AGTR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCGAAACCT

About this image

AGTR1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

HyStem+BMP4-induced E15 cells (HyStem+BMP4 inductio...)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See AGTR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AGTR1

SOURCE GeneReport for Unigene clusters: Hs.477887 Hs.740357

UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556

Tissue specificity: Liver, lung, adrenal and adrenocortical adenomas

SABiosciences Expression via Pathway-Focused PCR Arrays including AGTR1 (see all 6):

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Hypertension in human mouse rat

Endothelial Cell Biology in human mouse rat

Apoptosis 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AGTR1 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGTR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for AGTR1 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	AGTR1¹	angiotensin II receptor, type 1	73.91(n) 75.77(a)		396065 NM_205157.3 NP_990488.1
lizard (Anolis carolinensis)	Reptilia	AGTR1⁶	--	73(a)	1 ↔ 1	3(19290601-19291689)
African clawed frog (Xenopus laevis)	Amphibia	agtr1-A²	angiotensin II receptor, type 1	76.99(n)		U01155.1
zebrafish (Danio rerio)	Actinopterygii	agtr1a⁶ agtr1b⁶	angiotensin II receptor, type 1b	47(a) 45(a)	1 ↔ many 1 ↔ many	2(24701266-24702342) 24(4847526-4861772)

ENSEMBL Gene Tree for AGTR1 (if available)
TreeFam Gene Tree for AGTR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for AGTR1 gene

RXFP3² BDKRB1² AGTR2² GPR25² CXCR7² APLNR² GPR15² BDKRB2²

RXFP4² GPR182²

18/75 SIMAP similar genes for AGTR1 using alignment to 5 protein entries: AGTR1_HUMAN (see all proteins) (see all similar genes):

AT1 GPR18 AGTR2 CCR9 CXCR2 IL8RB

CCR7 CCR1 CCR4 CCR6 CXCR6 GPR1

CXCR1 CCBP2 CCR-5 GIR LPAR6 P2RY5

AGTR1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs104893677^1,2	C	pathogenic	237026020(+)	`GGACAC/TGGCCA`	10	T M	mis¹		0	--	--	--	--
rs12695863^1,2	C	--	145786111(+)	`TATCTT/ATGAAT`	4	--	us2k¹		4		NS NA	212
rs78066365^1,2	F,	--	145786121(+)	`TTTTTA/TAATTT`	4	--	us2k¹		1		WA	118
rs77577402^1,2		--	145786256(+)	`GCATCA/GAACTT`	4	--	us2k¹		1		NA	120
rs12721193^1,2	C,	--	145786588(+)	`AGATCA/GTGTCA`	4	--	us2k¹		4		NS NA	140
rs12721194^1,2	C	--	145786885(+)	`AAAAAT/ATTTTT`	4	--	us2k¹ tfbs³		4		NS NA	238
rs12721258^1,2	C,	--	145787142(+)	`GCATAT/CCCATC`	4	--	us2k¹		4		NS NA	146
rs422858^1,2	C,F,A,H,	--	145787857(-)	`TCACGCT/G /GG/TGGTCC`	4	--	us2k¹		9		NS EA WA NA	780
rs2307085^1,2	C,F,	--	145788235(+)	`AGACCC/AGCACC`	4	--	ut5¹ ese³		1		EA	1496
rs74662294^1,2	F,	--	145788451(+)	`GGCCAC/TACTTT`	4	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for AGTR1 (148415571 - 148460795 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AGTR1: --
Human Gene Mutation Database (HGMD): AGTR1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AGTR1

DNA2.0 Custom Variant and Variant Library Synthesis for AGTR1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

AGTR1 for disorders           About GeneDecksing

OMIM gene information: 106165
OMIM disorders: 145500  267430
UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556

Defects in AGTR1 are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive

severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably

due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype)

20/189 diseases for AGTR1 (see all 189): About MalaCards

aldosteronism mitral valve prolapse 21-hydroxylase deficiency cor pulmonale

renal tubular dysgenesis high blood pressure open-angle glaucoma subacute sclerosing panencephalitis

end stage renal failure posterior urethral valves vesicoureteral reflux focal segmental glomerulosclerosis

mesangial proliferative glomerulonephritis age related macular degeneration acute mountain sickness usual interstitial pneumonia

nephrogenic diabetes insipidus ureteral obstruction congenital diaphragmatic hernia diastolic heart failure

4 diseases from the University of Copenhagen DISEASES database for AGTR1:

Hypertension Heart disease Kidney disease Atherosclerosis

10/95 Novoseek disease relationships for AGTR1 gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
essential hypertension	76.6	62	8021009 (2), 9544872 (2), 10082497 (2), 11793845 (2) (see all 48)
diabetic nephropathies	73.2	43	12477969 (3), 19713965 (2), 10907125 (2), 8671962 (2) (see all 31)
renal disease	71	69	17506717 (4), 11996640 (3), 9741738 (3), 9818206 (3) (see all 50)
cardiovascular diseases	67.6	34	9449684 (2), 9702074 (2), 9740630 (1), 16519598 (1) (see all 31)
heart failure	66.4	102	9302352 (5), 8872858 (4), 11996651 (4), 10411851 (2) (see all 66)
ventricular hypertrophy	65.7	24	19997001 (2), 10351920 (2), 15612584 (2), 7498879 (2) (see all 18)
proteinuria	65	26	16923922 (2), 15446600 (2), 17665974 (1), 18497456 (1) (see all 21)
cardiac hypertrophy	62	26	9741738 (3), 10750587 (1), 10820928 (1), 11692158 (1) (see all 16)
hypertrophy	60.4	26	19588183 (2), 14985364 (2), 19074594 (1), 8987966 (1) (see all 23)
atherosclerosis	58.7	19	15998704 (1), 18475152 (1), 19275607 (1), 9702074 (1) (see all 17)

Genatlas disease: AGTR1

Bartter syndrome characterized by hypokalemic alkalosis,normal or hypercalciuria,normal magnesemia,early onset and

hyperreninemia,hyperaldosteronism,hyperplasia of the juxtaglomerular apparatus

Genetic Association Database (GAD): AGTR1
Human Genome Epidemiology (HuGE) Navigator: AGTR1 (433 documents)

Export disorders for AGTR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for AGTR1 gene, integrated from 9 sources (see all 1890):
(articles sorted by number of sources associating them with AGTR1)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor. (PubMed id 1550596)^{1, 2, 3} Takayanagi R.... Nawata H. (1992)
Type 1 angiotensin II receptors of adrenal tumors. (PubMed id 7792812)^{1, 2, 9} Nawata H.... Ohe K. (1995)
Multiple Polymorphisms in the renin- angiotensin-aldosterone system (ACE, CYP11B2, AGTR1) and their contribution to hypertension in African Americans and Latinos in the multiethnic cohort. (PubMed id 15545843)^{1, 4, 9} Henderson S.O....Mack W. (2004)
Novel subtype of human angiotensin II type 1 receptor: cDNA cloning and expression. (PubMed id 8135787)^{1, 2, 9} Konishi H.... Fujisawa Y. (1994)
1166C mutation of angiotensin II type 1 receptor gene is correlated with umbilical blood flow velocimetry in women with preeclampsia. (PubMed id 16076618)^{1, 4, 9} Seremak-Mrozikiewicz A....Mrozikiewicz P.M. (2005)
[ACE and AGTR1 genes polymorphisms in left ventricular hypertrophy pathogenesis in humans] (PubMed id 15612584)^{1, 4, 9} Makeeva O.A....Puzyrev V.P. (2004)
Endothelial nitric oxide synthase and angiotensin II type 1 receptor gene polymorphisms can influence chronic inflammatory state in renal transplant patients. (PubMed id 15848528)^{1, 4, 9} Sezer S....Haberal M. (2005)
[Polymorphic markers of GNB3 (C825T), AGTR1 (A1166C) and ACE (A2350G and I/D) genes in patients with arterial hypertension combined with diabetes mellitus type 2] (PubMed id 15332573)^{1, 4, 9} Karpov R.S....Atroshenkov A.V. (2004)
Polymorphisms in the angiotensinogen and angiotensin II type 1 receptor gene are related to change in left ventricular mass during antihypertensive treatment: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) trial. (PubMed id 11910301)^{1, 4, 9} Kurland L....Lind L. (2002)
Angiotensin II type 1 receptor gene adenine/cytosine1166 polymorphism is not associated with mitral valve prolapse syndrome in Taiwan Chinese. (PubMed id 11999641)^{1, 4, 9} Chou H.T....Tsai F.J. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 185	HGNC: 336	AceView: AGTR1	Ensembl:ENSG00000144891	euGenes: HUgn185
ECgene: AGTR1	Kegg: 185	H-InvDB: AGTR1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for AGTR1	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/AGTR1
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=AGTR1
Wikipedia	http://en.wikipedia.org/wiki/Angiotensin_receptor

Intellectual Property for AGTR1 gene
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Patent Information for AGTR1 gene:
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GeneCards and IP:
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AGTR1 Gene

angiotensin II receptor, type 1

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Microalbuminuria
Dementia
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Hyperinsulinemia
essential hypertension
Raynauds Phenomenon
Acute myocardial infarction
Hyperlipidemia
insulin sensitivity
Myocardial Ischemia
Atherosclerosis
Edema
Hypercholesterolemia
Adenocarcinoma
Vesicoureteral Reflux
Ureteral obstruction
MYOCARDIAL FIBROSIS
Obstruction
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PULMONARY HYPOPLASIA
Coronary Atherosclerosis
Cardiomyopathy
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Ovarian Cancer
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glomerulosclerosis
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prostate cancer
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Aldosteronism Primary
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INFARCT
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renal scleroderma
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Effects Cardiovascular
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Carcinoma Renal Cell
HEART FAILURE
Myocardial Infarction
Albuminuria
Carcinoma Adrenocortical
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Hyperaldosteronism
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restenosis
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ventricular hypertrophy
ADRENAL TUMOR
STROKE
Vascular Diseases
Hypertension Renovascular
CEREBROVASCULAR DISEASE
Glomerulonephritis
NIDDM
Renal Failure Chronic
angiotensin hypertension
Arthritis
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AGTR1 Gene

angiotensin II receptor, type 1

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