Aliases for AGTR1 Gene
External Ids for AGTR1 Gene
Previous HGNC Symbols for AGTR1 Gene
Previous GeneCards Identifiers for AGTR1 Gene
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for AGTR1 Gene
AGTR1 (Angiotensin II Receptor, Type 1) is a Protein Coding gene. Diseases associated with AGTR1 include hypertension, essential and cardiovascular disease risk factor. Among its related pathways are Signaling by GPCR and p70S6K Signaling. GO annotations related to this gene include protein heterodimerization activity and acetyltransferase activator activity. An important paralog of this gene is ACKR3.
UniProtKB/Swiss-Prot for AGTR1 Gene
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
The angiotensin1 receptors (AT1) are a member of the angiotensin group of G-protein-coupled receptors that also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung where they play a role in vasoconstriction, aldosterone and vasopressin release, salt and water retention, cell proliferation and migration and sympathetic stimulation. Most species express a single AT1 gene, but two related genes AT1A and AT1B are found in rodents. The human AT1 receptor gene has been localized to chromosome 3 (3q21-q25).