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AGTR1 Gene

protein-coding   GIFtS: 73
GCID: GC03P148415

Angiotensin II Receptor, Type 1

(Previous name: angiotensin receptor 1B)
(Previous symbol: AGTR1B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Angiotensin II Receptor, Type 11 2     AG2S2
AGTR1B1 2 3     AT1B2
AT2R12 3 5     AT1R2
AT12 3     HAT1R2
AT1AR2 3     Type-1 Angiotensin II Receptor2
AT1BR2 3     Type-1B Angiotensin II Receptor2
AGTR1A3 5     AT2R1B3
Angiotensin Receptor 1B1     Angiotensin II Type-1 Receptor3

External Ids:    HGNC: 3361   Entrez Gene: 1852   Ensembl: ENSG000001448917   OMIM: 1061655   UniProtKB: P305563   

Export aliases for AGTR1 gene to outside databases

Previous GC identifers: GC03P145407 GC03P149300 GC03P149697 GC03P149736 GC03P149898 GC03P145788


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AGTR1 Gene:
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an
important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least
two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major
cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias
following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related
gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in
humans. Multiple alternatively spliced transcript variants have been reported for this gene. (provided by RefSeq,
Jul 2012)

GeneCards Summary for AGTR1 Gene:
AGTR1 (angiotensin II receptor, type 1) is a protein-coding gene. Diseases associated with AGTR1 include posterior urethral valves, and posterior urethral valve. GO annotations related to this gene include acetyltransferase activator activity and protein heterodimerization activity. An important paralog of this gene is RXFP3.

UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556
Function: Receptor for angiotensin II. Mediates its action by association with G proteins that activate a
phosphatidylinositol-calcium second messenger system

summary for AGTR1 Gene:
The angiotensin1 receptors (AT1) are a member of the angiotensin group of G-protein-coupled receptors that
also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung where
they play a role in vasoconstriction, aldosterone and vasopressin release, salt and water retention, cell
proliferation and migration and sympathetic stimulation. Most species express a single AT1 gene, but two
related genes AT1A and AT1B are found in rodents. The human AT1 receptor gene has been localized to
chromosome 3 (3q21-q25).

Gene Wiki entry for AGTR1 (Angiotensin II receptor type 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the AGTR1 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for AGTR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGTR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24   Ensembl cytogenetic band:  3q24   HGNC cytogenetic band: 3q24

AGTR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGTR1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P148415:  view genomic region     (about GC identifiers)

Start:
148,415,571 bp from pter      End:
148,460,795 bp from pter
Size:
45,225 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556 (See protein sequence)
Recommended Name: Type-1 angiotensin II receptor  
Size: 359 amino acids; 41061 Da
Subunit: Interacts with MAS1 (Probable). Interacts with ARRB1 (By similarity)
1 PDB 3D structure from and Proteopedia for AGTR1:
1ZV0 (3D)    
Secondary accessions: Q13725 Q8TBK4

Explore the universe of human proteins at neXtProt for AGTR1: NX_P30556

Explore proteomics data for AGTR1 at MOPED

Post-translational modifications: 

  • C-terminal Ser or Thr residues may be phosphorylated1
  • Glycosylation2 at Asn4, Asn176, Asn188
  • Modification sites at PhosphoSitePlus

  • See AGTR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_000676.1  NP_004826.5  NP_033611.1  NP_114038.4  NP_114438.2  

    ENSEMBL proteins: 
     ENSP00000419422   ENSP00000273430   ENSP00000385612   ENSP00000419783   ENSP00000418084  
     ENSP00000418851   ENSP00000443186   ENSP00000398832   ENSP00000385641  
    Reactome Protein details: P30556

    AGTR1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant AGTR1 Protein
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for AGTR1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for AGTR1
    GenScript Custom Purified and Recombinant Proteins Services for AGTR1
    Novus Biologicals AGTR1 Proteins
    Novus Biologicals AGTR1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AGTR1

    AGTR1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of AGTR1
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    Novus Biologicals AGTR1 Antibodies
    Abcam antibodies for AGTR1
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    ThermoFisher Antibody for AGTR1
    LSBio Antibodies in human, mouse, rat for AGTR1

    AGTR1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript AGTR1-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AGTR1
    Cloud-Clone Corp. CLIAs for AGTR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AGTR: GPCR / Class A : Angiotensin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: AT1 receptor
    Angiotensin receptors

    4 InterPro protein domains:
     IPR000190 ATII_AT1_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000248 ATII_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P30556

    ProtoNet protein and cluster: P30556

    2 Blocks protein domains:
    IPB000190 AT1 angiotensin II receptor signature
    IPB000248 Angiotensin II receptor signature


    UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556
    Similarity: Belongs to the G-protein coupled receptor 1 family


    AGTR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AGTR1_HUMAN, P30556
    Function: Receptor for angiotensin II. Mediates its action by association with G proteins that activate a
    phosphatidylinositol-calcium second messenger system

         Genatlas biochemistry entry for AGTR1:
    angiotensin II (type-1) receptor,G protein coupled receptor superfamily,including two subtypes AT1A and AT1B,major
    blood pressure regulator (activation of vascular growth),inhibiting adenylate cyclase,activating phospholipase C
    and A2,contributing in association with ACE to the risk of coronary disease,localized in the substantia nigra,
    the caudate nucleus and putamen (neuromodulator),blood vessels ,heart (conduction system) and kidney (renal
    medullary interstitial cells)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001596angiotensin type I receptor activity IPI1378723
    GO:0004930G-protein coupled receptor activity ----
    GO:0004945angiotensin type II receptor activity IDA15611106
    GO:0005515protein binding IPI1378723
    GO:0010698acetyltransferase activator activity ----
         
    AGTR1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for AGTR1:
     Decreased substrate adherent c  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Agtr1b):
     cardiovascular system  growth/size/body  homeostasis/metabolism  immune system  mortality/aging 
     renal/urinary system 

    AGTR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Agtr1btm1Cof for AGTR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AGTR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AGTR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AGTR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AGTR1

    miRNA
    Products:
        
    miRTarBase miRNAs that target AGTR1:
    hsa-mir-155-5p (MIRT002006), hsa-mir-26b-5p (MIRT030131), hsa-mir-124-3p (MIRT023107)

    Block miRNA regulation of human, mouse, rat AGTR1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate AGTR1:
    hsa-miR-4330
    SwitchGear 3'UTR luciferase reporter plasmidAGTR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AGTR1
    Predesigned siRNA for gene silencing in human, mouse, rat AGTR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AGTR1

    Clone
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    OriGene clones in human, mouse for AGTR1 (see all 29)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): AGTR1 (NM_000685)
    Sino Biological Human cDNA Clone for AGTR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGTR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGTR1

    Cell Line
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    GenScript AGTR1-overexpressing Cell Line for Assay
    Browse ESI BIO Cell Lines and PureStem Progenitors for AGTR1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGTR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AGTR1_HUMAN, P30556: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    nucleus2
    cytoskeleton1
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IC1378723
    GO:0016021integral component of membrane NAS8135787

    AGTR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AGTR1 About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    2Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics0.37
    ACE Inhibitor Pathway, Pharmacodynamics0.00
    Renin-angiotensin system0.37
    ACE Inhibitor Pathway0.00
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Development Angiotensin activation of ERK
    Development Angiotensin activation of ERK0.74
    Cell adhesion Integrin inside out signaling0.44
    Development Angiotensin signaling via PYK20.67

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for AGTR1
        Renin-Angiotensin Pathway
    JAK-STAT Pathway

    4 GeneGo (Thomson Reuters) Pathways for AGTR1
        Development Angiotensin activation of ERK
    Development Angiotensin signaling via beta-Arrestin
    Cell adhesion Integrin inside-out signaling
    Development Angiotensin signaling via PYK2

    5 BioSystems Pathways for AGTR1
        ACE Inhibitor Pathway
    GPCRs, Class A Rhodopsin-like
    Arf6 signaling events
    Angiopoietin receptor Tie2-mediated signaling
    Peptide GPCRs


    2 Reactome Pathways for AGTR1
        Peptide ligand-binding receptors
    G alpha (q) signalling events

    3 PharmGKB Pathways for AGTR1
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Losartan Pathway, Pharmacokinetics

    5 Kegg Pathways  (Kegg details for AGTR1):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Adrenergic signaling in cardiomyocytes
    Vascular smooth muscle contraction
    Renin-angiotensin system


    AGTR1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AGTR1 (see all 6): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AGTR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AGTR1 (P305561, 2, 3 ENSP000002734304) via UniProtKB, MINT, STRING, and/or I2D (see all 151)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCG1P191742, 3, ENSP000002440074MINT-8029402 I2D: score=2 STRING: ENSP00000244007
    AGTP010191, 3, ENSP000003556274EBI-6623016,EBI-6622938 I2D: score=1 STRING: ENSP00000355627
    GNAQP501482, 3, ENSP000002865484MINT-4791922 I2D: score=1 STRING: ENSP00000286548
    ARRB1P494072, 3, ENSP000003771414MINT-4791905 I2D: score=2 STRING: ENSP00000377141
    AGTRAPQ6RW133, ENSP000003197134I2D: score=4 STRING: ENSP00000319713
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth NAS17159080
    GO:0001822kidney development IMP16116425
    GO:0002018renin-angiotensin regulation of aldosterone production NAS17159080
    GO:0002034regulation of blood vessel size by renin-angiotensin IC10993080
    GO:0003081regulation of systemic arterial blood pressure by renin-angiotensin IC1378723

    AGTR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for AGTR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Valsartan High affinity, selective AT1 antagonist [137862-53-4]
    EMD 66684 Potent, selective non-peptide AT1 antagonist [187683-79-0]
    AzilsartanPotent AT1 receptor inverse agonist; antihypertensive[147403-03-0]
    ZD 7155 hydrochlorideSelective non-peptide AT1 antagonist[146709-78-6]
    Losartan potassium Selective, non-peptide AT1 antagonist [124750-99-8]

    4 HMDB Compounds for AGTR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Aldosterone(+)-Aldosterone (see all 22)52-39-118326554
    Angiotensin IIHypertensin (see all 11)11128-99-7--
    BradykininCallidin I (see all 5)58-82-2--
    CalciumCa (see all 2)7440-70-2--

    Selected DrugBank Compounds for AGTR1 (see all 11)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    TelmisartanBIBR 277 (see all 2)144701-48-4targetantagonist20448797 17691961 18580862 15498586 11444497 15617852 11752352 19147680 11408526 9259062 16938288 10067800 11558835 9878991
    Irbesartan-- 138402-11-6targetantagonist10822210 11486244 15101793 10082498 14716205 17408613 7843749 11752352 10069682 18627212 15030294 10075381 10373224
    Candesartan-- 139481-59-7targetantagonist10826401 16601569 19563275 16901636 17588300 10805052 11752352 12504781 19436650 10968199 9892163
    Eprosartan-- 133040-01-4targetantagonist12927226 10856732 12782193 12184062 12766389 11752352 12517247 11320369 9602957 12540520 18093407
    LosartanDuP 89 (see all 2)114798-26-4targetantagonist15026875 15991937 12710529 11752352 15573751 12719755
    OlmesartanDE-092 (see all 3)144689-63-4targetantagonist16220064 17163232 11451212 12076183 11752352 16775509
    Valsartan-- 137862-53-4targetantagonist12460705 8242249 15579516 11752352 12023686 8577935
    Forasartan-- 145216-43-9targetantagonist8981065 11752352 11569611 9156352
    Tasosartan-- 145733-36-4targetantagonist11046101 11683476 12113820 11752352
    Azilsartan medoxomilAzilsartan (see all 6)147403-03-0targetantagonist11752352 23563275

    Selected IUPHAR Ligands for AGTR1 (AT1 receptor) (see all 15)    About this table
    LigandTypeActionAffinityPubmed IDs
    angiotensin I
    AgonistFull agonist9.6 - 10--
    candesartan
    AntagonistAntagonist9.5 - 9.710193788
    EXP3174
    AntagonistAntagonist7.4 - 9.510193788 8372104
    angiotensin-(1-7)
    AgonistFull agonist9.3 - 9.4--
    angiotensin II
    AgonistFull agonist9 - 9.310193788
    [3H]valsartan
    AntagonistAntagonist8.8 - 911206708
    eprosartan
    AntagonistAntagonist8.4 - 8.81309870
    irbesartan
    AntagonistAntagonist8.7 - 8.810193788
    losartan
    AntagonistAntagonist7.4 - 8.78372104
    valsartan
    AntagonistAntagonist8.618577935

    Selected Novoseek inferred chemical compound relationships for AGTR1 gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    losartan 93.9 298 7556378 (3), 19487683 (3), 16601194 (2), 9211022 (2) (see all 99)
    candesartan 91.9 94 19760950 (2), 16766543 (2), 18854846 (2), 11800413 (2) (see all 74)
    valsartan 88.9 58 16206603 (2), 17395057 (2), 19307231 (2), 12688405 (2) (see all 50)
    pd123319 88.7 37 9918526 (1), 10419063 (1), 15953595 (1), 8913541 (1) (see all 29)
    telmisartan 87.9 48 18158351 (2), 18380932 (2), 20056982 (2), 17122147 (2) (see all 37)
    olmesartan 87.1 36 17608670 (2), 11588406 (1), 16148612 (1), 19047580 (1) (see all 31)
    irbesartan 86.9 63 14962486 (2), 11791028 (2), 12184030 (2), 11910301 (2) (see all 37)
    ang ii 86.7 95 16112405 (4), 17630322 (4), 10467229 (3), 15905175 (3) (see all 56)
    cgp42112a 83 16 8675601 (2), 8243303 (2), 10696069 (1), 9239679 (1) (see all 11)
    eprosartan 82.7 16 11580885 (2), 12927226 (2), 12359982 (1), 15366789 (1) (see all 13)

    2 PharmGKB related drug/compound annotations for AGTR1 gene    About this table
    Drug/compound PharmGKB Annotation
    captoprilCA  
    perindoprilCA  



    AGTR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for AGTR1 gene (5 alternative transcripts): 
    NM_000685.4  NM_004835.4  NM_009585.3  NM_031850.3  NM_032049.3  

    Unigene Cluster for AGTR1:

    Angiotensin II receptor, type 1
    Hs.477887  [show with all ESTs]
    Unigene Representative Sequence: M87290
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497524(uc003ewj.3) ENST00000349243(uc003ewi.3) ENST00000404754
    ENST00000475166 ENST00000475347 ENST00000474935 ENST00000461609 ENST00000542281(uc003ewg.3)
    ENST00000418473(uc003ewh.3) ENST00000402260(uc003ewk.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AGTR1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate AGTR1:
    hsa-miR-4330
    SwitchGear 3'UTR luciferase reporter plasmidAGTR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AGTR1
    Predesigned siRNA for gene silencing in human, mouse, rat AGTR1
    Clone
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    OriGene clones in human, mouse for AGTR1 (see all 29)
    OriGene ORF clones in mouse, rat for AGTR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): AGTR1 (NM_000685)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGTR1
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    Additional mRNA sequence: 

    D13814.1 M87290.1 X65699.1 

    9 DOTS entries:

    DT.91753556  DT.100793614  DT.91753566  DT.100035887  DT.100035892  DT.100793608  DT.100793625  DT.95162616 
    DT.99966243 

    Selected AceView cDNA sequences (see all 110):

    AA470024 BU150328 CR601313 AU136693 CR600504 CR593142 BX106176 CB989105 
    AL542674 AI911517 AL547734 T28644 AI654811 CD013885 AU139387 BC022447 
    BC068494 BX089691 NM_009585 NM_032049 CF147788 BG573153 AI768584 NM_004835 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for AGTR1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                    -     -     -     -                     
    SP2:                                                            
    SP3:                                      -                     
    SP4:              -     -     -     -     -                     
    SP5:                                      -                     


    ECgene alternative splicing isoforms for AGTR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    AGTR1 expression in normal human tissues (normalized intensities)      AGTR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCGAAACCT
    AGTR1 Expression
    About this image


    AGTR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced embryoid bodies
     
     Bone (Muscoskeletal System)
             HyStem+BMP4-induced E15 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+BMP4-induced E15 cells
     
     Epidermis (Integumentary System)
             Detroit 551
     
     Fibroblasts
             Detroit 551
    AGTR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AGTR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.477887

    UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556
    Tissue specificity: Liver, lung, adrenal and adrenocortical adenomas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AGTR1 (see all 6): 
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              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Apoptosis 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AGTR1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agtr1b5
    Agtr1a1
    angiotensin II receptor, type 1b5
    angiotensin II receptor, type 1a1
    87(n)1
    94.43(a)1
      3 (6.37 cM)5
    116071  NM_177322.31  NP_796296.11 
     203144735 
    chicken
    (Gallus gallus)
    Aves AGTR11 angiotensin II receptor, type 1 73.91(n)
    75.77(a)
      396065  NM_205157.3  NP_990488.1 
    lizard
    (Anolis carolinensis)
    Reptilia AGTR16
    angiotensin II receptor, type 1
    73(a)
    1 ↔ 1
    3(19290601-19291689)
    African clawed frog
    (Xenopus laevis)
    Amphibia agtr1-A2 angiotensin II receptor, type 1 76.99(n)    U01155.1 
    zebrafish
    (Danio rerio)
    Actinopterygii agtr1a6
    agtr1b6
    angiotensin II receptor, type 1b
    47(a)
    45(a)
    1 ↔ many
    1 ↔ many
    2(24701260-24702342) ENSDARG00000018616
    24(4847526-4861772) ENSDARG00000045443


    ENSEMBL Gene Tree for AGTR1 (if available)
    TreeFam Gene Tree for AGTR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AGTR1 gene
    RXFP32  BDKRB12  AGTR22  GPR252  APLNR2  BDKRB22  ACKR32  GPR152  
    RXFP42  GPR1822  
    Selected SIMAP similar genes for AGTR1 using alignment to 4 protein entries:     AGTR1_HUMAN (see all proteins) (see all similar genes):
    AT1    GPR18    AGTR2    CCR9    CXCR2    IL8RB
    CCR1    CCR7    CCR4    CCR6    CXCR6    GPR1
    CMKLR1    CXCR1    ACKR2    CCBP2    CCR-5    GIR

    AGTR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AGTR1 (see all 1015)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0350864
    Renal tubular dysgenesis (RTD)4--see VAR_0350862 T M mis40--------
    rs1048936771,2
    Cpathogenic1148443149(+) GGACAC/TGGCCA 10 T M mis10--------
    rs3743797301,2
    C--145793994(+) TTTTT-/TAAAAA 4 -- int10--------
    rs113719121,2
    C--145810511(+) CAAATC/-TATTA 4 -- int15Minor allele frequency- -:0.08NS NA CSA 180
    rs1899581091,2
    --148397187(+) CTTTTC/GATCTA 4 -- us2k10--------
    rs126958631,2
    C--148397217(+) TATCTT/ATGAAT 4 -- us2k14Minor allele frequency- A:0.01NS NA 212
    rs780663651,2
    F--148397227(+) TTTTTA/TAATTT 4 -- us2k11Minor allele frequency- T:0.06WA 118
    rs775774021,2
    F--148397362(+) GCATCA/GAACTT 4 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1151778871,2
    F--148397404(+) CTTGAC/TAGATC 4 -- us2k11Minor allele frequency- T:0.01WA 118
    rs127211931,2
    C,F--148397694(+) AGATCA/GTGTCA 4 -- us2k14Minor allele frequency- G:0.01NS NA 140

    HapMap Linkage Disequilibrium report for AGTR1 (148415571 - 148460795 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for AGTR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv877636CNV Loss21882294
    nsv877638CNV Gain21882294
    nsv877637CNV Gain21882294

    Human Gene Mutation Database (HGMD): AGTR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AGTR1
    DNA2.0 Custom Variant and Variant Library Synthesis for AGTR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 106165   
    OMIM disorders: 145500  267430  
    UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556
  • Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular
    development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia
    from early-onset oligohydramnios (the Potter phenotype). Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • Selected diseases for AGTR1 (see all 179):    About MalaCards
    posterior urethral valves    posterior urethral valve    cardiovascular disease risk factor    renal tubular dysgenesis, agtr1-related
    left ventricular outflow tract obstruction    mitral valve prolapse    hypertensive heart disease    hypertensive encephalopathy
    nephrosclerosis    essential hypertension    urethritis    anuria
    mitral valve disease    ureteral obstruction    renal tubular dysgenesis    diastolic heart failure
    mesangial proliferative glomerulonephritis    in situ carcinoma    familial hyperaldosteronism    proliferative glomerulonephritis

    4 diseases from the University of Copenhagen DISEASES database for AGTR1:
    Hypertension     Heart disease     Kidney disease     Atherosclerosis

    AGTR1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for AGTR1 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    essential hypertension 76.6 62 8021009 (2), 9544872 (2), 10082497 (2), 11793845 (2) (see all 48)
    diabetic nephropathies 73.2 43 12477969 (3), 19713965 (2), 10907125 (2), 8671962 (2) (see all 31)
    renal disease 71 69 17506717 (4), 11996640 (3), 9741738 (3), 9818206 (3) (see all 50)
    cardiovascular diseases 67.6 34 9449684 (2), 9702074 (2), 9740630 (1), 16519598 (1) (see all 31)
    heart failure 66.4 102 9302352 (5), 8872858 (4), 11996651 (4), 10411851 (2) (see all 66)
    ventricular hypertrophy 65.7 24 19997001 (2), 10351920 (2), 15612584 (2), 7498879 (2) (see all 18)
    proteinuria 65 26 16923922 (2), 15446600 (2), 17665974 (1), 18497456 (1) (see all 21)
    cardiac hypertrophy 62 26 9741738 (3), 10750587 (1), 10820928 (1), 11692158 (1) (see all 16)
    hypertrophy 60.4 26 19588183 (2), 14985364 (2), 19074594 (1), 8987966 (1) (see all 23)
    atherosclerosis 58.7 19 15998704 (1), 18475152 (1), 19275607 (1), 9702074 (1) (see all 17)

    Genatlas disease: AGTR1
    Bartter syndrome characterized by hypokalemic alkalosis,normal or hypercalciuria,normal magnesemia,early onset
    and hyperreninemia,hyperaldosteronism,hyperplasia of the juxtaglomerular apparatus

    Genetic Association Database (GAD): AGTR1
    Human Genome Epidemiology (HuGE) Navigator: AGTR1 (433 documents)

    Export disorders for AGTR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AGTR1 gene, integrated from 10 sources (see all 1944):
    (articles sorted by number of sources associating them with AGTR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor. (PubMed id 1550596)1, 2, 3 Takayanagi R.... Nawata H. (Biochem. Biophys. Res. Commun. 1992)
    2. Polymorphisms in angiotensin II type 1 receptor and angiotensin I-converting enzyme genes and breast cancer risk among Chinese women in Singapore. (PubMed id 15498791)1, 4, 9 Koh W.P....Yu M.C. (Carcinogenesis 2005)
    3. Polymorphism in the angiotensin II type 1 receptor (AGTR1) is associated with age at diagnosis in pulmonary arterial hypertension. (PubMed id 19332265)1, 4, 9 Chung W.K....Morse J.H. (J. Heart Lung Transplant. 2009)
    4. Association between the AGTR1 polymorphism +1166A&gt;C and serum levels of high-sensitivity C-reactive protein. (PubMed id 19026696)1, 4, 9 Suchankova P....Ekman A. (Regul. Pept. 2009)
    5. Type 1 angiotensin II receptors of adrenal tumors. (PubMed id 7792812)1, 2, 9 Nawata H.... Ohe K. (Steroids 1995)
    6. Genetic polymorphisms of the angiotensin II type 1 receptor gene and diastolic heart failure. (PubMed id 19330904)1, 4, 9 Wu C.K....Chiang F.T. (J. Hypertens. 2009)
    7. Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: a HuGE review. (PubMed id 18641512)1, 4, 9 Mottl A.K....North K.E. (Genet. Med. 2008)
    8. Differential roles of Angiotensinogen and Angiotensin Receptor type 1 polymorphisms in breast cancer risk. (PubMed id 16823505)1, 4, 9 GonzA!lez-Zuloeta Ladd A.M....van Duijn C.M. (Breast Cancer Res. Treat. 2007)
    9. [Mutation screening in Angiotensin II receptors, AGTR1 and AGTR2, and evaluation of AGTR1 polymorphisms C573T and A1166C in patients with premature adrenarche]. (PubMed id 17160213)1, 4, 9 Moura M.S....Monte O. (Arq Bras Endocrinol Metabol 2006)
    10. Multiple Polymorphisms in the renin- angiotensin-aldosterone system (ACE, CYP11B2, AGTR1) and their contribution to hypertension in African Americans and Latinos in the multiethnic cohort. (PubMed id 15545843)1, 4, 9 Henderson S.O....Mack W. (Am. J. Med. Sci. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 185 HGNC: 336 AceView: AGTR1 Ensembl:ENSG00000144891 euGenes: HUgn185
    ECgene: AGTR1 Kegg: 185 H-InvDB: AGTR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AGTR1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=AGTR1[genesymbol]
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=AGTR1
    Wikipedia http://en.wikipedia.org/wiki/Angiotensin_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AGTR1 gene:
    Search GeneIP for patents involving AGTR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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