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Aliases for AGTR1 Gene

Aliases for AGTR1 Gene

  • Angiotensin II Receptor Type 1 2 3 5
  • AGTR1B 3 4
  • AT1AR 3 4
  • AT1BR 3 4
  • AT2R1 3 4
  • AT1 3 4
  • Type-1B Angiotensin II Receptor 3
  • Type-1 Angiotensin II Receptor 3
  • Angiotensin II Type-1 Receptor 4
  • Angiotensin Receptor 1B 2
  • AGTR1A 4
  • AT2R1B 4
  • HAT1R 3
  • AG2S 3
  • AT1B 3
  • AT1R 3

External Ids for AGTR1 Gene

Previous HGNC Symbols for AGTR1 Gene

  • AGTR1B

Previous GeneCards Identifiers for AGTR1 Gene

  • GC03P145407
  • GC03P149300
  • GC03P149697
  • GC03P149736
  • GC03P149898
  • GC03P148415
  • GC03P145788

Summaries for AGTR1 Gene

Entrez Gene Summary for AGTR1 Gene

  • Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for AGTR1 Gene

AGTR1 (Angiotensin II Receptor Type 1) is a Protein Coding gene. Diseases associated with AGTR1 include Renal Tubular Dysgenesis and Hypertension, Essential. Among its related pathways are Signaling by GPCR and AGE-RAGE signaling pathway in diabetic complications. GO annotations related to this gene include G-protein coupled receptor activity and angiotensin type II receptor activity. An important paralog of this gene is AGTR2.

UniProtKB/Swiss-Prot for AGTR1 Gene

  • Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for AGTR1 Gene

  • The angiotensin1 receptor (AT1) is a member of the angiotensin group of G-protein-coupled receptors that also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung. AT1 receptors preferentially bind angiotensin II.

Gene Wiki entry for AGTR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGTR1 Gene

Genomics for AGTR1 Gene

Regulatory Elements for AGTR1 Gene

Enhancers for AGTR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F148648 1.1 Ensembl ENCODE 19.3 -48.8 -48799 1.4 CTCF JUND ZNF654 SMC3 FOS RAD21 MAFK AGTR1 GC03M148696 LOC105374150
GH03F148697 1 ENCODE 14.9 +0.1 52 1.1 ZNF263 DRAP1 PKNOX1 SP3 L3MBTL2 MAX ARID4B ZNF48 RAD21 YY1 AGTR1 CPB1
GH03F148699 0.2 Ensembl 13.9 +2.2 2217 1.2 AGTR1 CPB1
GH03F148723 0.8 Ensembl ENCODE 11.5 +26.0 26046 1.0 HLF SIN3A CEBPB CEBPG RARA NFIL3 JUND CEBPA SMAD4 FOS AGTR1 RPL38P1 CPB1
GH03F148642 1.1 Ensembl ENCODE 8.5 -54.3 -54284 1.8 BHLHE40 TEAD4 CEBPB NFE2 MAFK NR2F2 NFE2L2 AGTR1 GC03M148696 LOC105374150
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around AGTR1 on UCSC Golden Path with GeneCards custom track

Promoters for AGTR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001376239 516 1800 DRAP1 PKNOX1 MAX ARID4B ZNF48 RAD21 YY1 POLR2A HOMEZ EZH2

Genomic Location for AGTR1 Gene

Chromosome:
3
Start:
148,697,784 bp from pter
End:
148,743,008 bp from pter
Size:
45,225 bases
Orientation:
Plus strand

Genomic View for AGTR1 Gene

Genes around AGTR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGTR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGTR1 Gene

Proteins for AGTR1 Gene

  • Protein details for AGTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30556-AGTR1_HUMAN
    Recommended name:
    Type-1 angiotensin II receptor
    Protein Accession:
    P30556
    Secondary Accessions:
    • Q13725
    • Q8TBK4

    Protein attributes for AGTR1 Gene

    Size:
    359 amino acids
    Molecular mass:
    41061 Da
    Quaternary structure:
    • Interacts with MAS1 (Probable) (PubMed:15809376). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).

    Three dimensional structures from OCA and Proteopedia for AGTR1 Gene

neXtProt entry for AGTR1 Gene

Post-translational modifications for AGTR1 Gene

  • C-terminal Ser or Thr residues may be phosphorylated.
  • Glycosylation at Asn 4, Asn 176, and Asn 188
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for AGTR1 Gene

Domains & Families for AGTR1 Gene

Gene Families for AGTR1 Gene

Graphical View of Domain Structure for InterPro Entry

P30556

UniProtKB/Swiss-Prot:

AGTR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with AGTR1: view

Function for AGTR1 Gene

Molecular function for AGTR1 Gene

GENATLAS Biochemistry:
angiotensin II (type-1) receptor,G protein coupled receptor superfamily,including two subtypes AT1A and AT1B,major blood pressure regulator (activation of vascular growth),inhibiting adenylate cyclase,activating phospholipase C and A2,contributing in association with ACE to the risk of coronary disease,localized in the substantia nigra, the caudate nucleus and putamen (neuromodulator),blood vessels ,heart (conduction system) and kidney (renal medullary interstitial cells)
UniProtKB/Swiss-Prot Function:
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Gene Ontology (GO) - Molecular Function for AGTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001596 angiotensin type I receptor activity IPI 1378723
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004945 angiotensin type II receptor activity IEA,IDA 1567413
GO:0005515 protein binding IPI 1378723
genes like me logo Genes that share ontologies with AGTR1: view
genes like me logo Genes that share phenotypes with AGTR1: view

Human Phenotype Ontology for AGTR1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for AGTR1 Gene

MGI Knock Outs for AGTR1:

Animal Model Products

miRNA for AGTR1 Gene

miRTarBase miRNAs that target AGTR1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for AGTR1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for AGTR1 Gene

Localization for AGTR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGTR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGTR1 Gene COMPARTMENTS Subcellular localization image for AGTR1 gene
Compartment Confidence
cytosol 5
plasma membrane 5
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
nucleus 2
endosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AGTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IC 1378723
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 8135787
genes like me logo Genes that share ontologies with AGTR1: view

Pathways & Interactions for AGTR1 Gene

genes like me logo Genes that share pathways with AGTR1: view

SIGNOR curated interactions for AGTR1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for AGTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 17159080
GO:0001822 kidney development IMP 16116425
GO:0002018 renin-angiotensin regulation of aldosterone production NAS 17159080
GO:0002034 regulation of blood vessel diameter by renin-angiotensin IC 10993080
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin IC 1378723
genes like me logo Genes that share ontologies with AGTR1: view

Drugs & Compounds for AGTR1 Gene

(151) Drugs for AGTR1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Olmesartan Approved, Investigational Pharma Antagonist, antagonist, Target Potent AT1 antagonist; metabolite of Olmesartan medoxomil (Cat. No. 4620) 126
Candesartan Approved Pharma Antagonist, antagonist, Target Angiotensin II receptor 1 (AT1) antagonist 156
Losartan Approved Pharma Antagonist, antagonist, Target 282
Valsartan Approved, Investigational Pharma Antagonist, antagonist, Target Angiotensin II AT1 receptor antagonist, High affinity, selective AT1 antagonist 291
Telmisartan Approved, Investigational Pharma Antagonist, antagonist, Target AT1 antagonist; PPARgamma partial agonist 264

(52) Additional Compounds for AGTR1 Gene - From: IUPHAR, Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]eprosartan
Antagonist
angiotensin I
Full agonist, Agonist
angiotensin-(1-7)
Full agonist, Agonist
L-162313
Full agonist, Agonist
4-Hydroxyvalsartan

(5) Tocris Compounds for AGTR1 Gene

Compound Action Cas Number
Losartan potassium Selective, non-peptide AT1 antagonist 124750-99-8
Olmesartan Potent AT1 antagonist; metabolite of Olmesartan medoxomil (Cat. No. 4620) 144689-24-7
Telmisartan AT1 antagonist; PPARgamma partial agonist 144701-48-4
Valsartan High affinity, selective AT1 antagonist 137862-53-4
ZD 7155 hydrochloride Selective non-peptide AT1 antagonist 146709-78-6

(34) ApexBio Compounds for AGTR1 Gene

Compound Action Cas Number
Acetyl Angiotensinogen (1-14), porcine Angiotensinogen precursor 66641-26-7
Angiotensin (1-7) Vasoconstriction peptide hormone 51833-78-4
Angiotensin 1/2 (1-5) Vasoconstrictor 58442-64-1
Angiotensin 1/2 (1-6) Vasoconstrictor 47896-63-9
Angiotensin 1/2 (1-9) Vasoconstrictor 34273-12-6
Angiotensin 1/2 + A (2 - 8) 51833-76-2
Angiotensin I (human, mouse, rat) Precursor of angiotensin II 484-42-4
Angiotensin II Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. 68521-88-0
Angiotensin II human 4474-91-3
Angiotensin III (human, mouse) Aldosterone stimulator 13602-53-4
AVE 0991 Agonist of angiotensin-(1-7) receptor 304462-19-9
AVE 0991 sodium salt Ang-(1-7) receptor Mas agonist 306288-04-0
Azilsartan 147403-03-0
Azilsartan Medoxomil Angiotensin II receptor type 1 antagonist 863031-21-4
Azilsartan medoxomil monopotassium Angiotensin II receptor type 1 antagonist 863031-24-7
Biapenem 120410-24-4
Candesartan Angiotensin II receptor 1 (AT1) antagonist 139481-59-7
CGP 42112 127060-75-7
EMD 66684 1216884-39-7
Eprosartan Mesylate 144143-96-4
Fimasartan 247257-48-3
Irbesartan Angiotensin II inhibitor 138402-11-6
LCZ696 936623-90-4
Losartan 114798-26-4
Losartan Potassium (DuP 753) Angiotensin AT1 receptor antagonist 124750-99-8
Novokinin 358738-77-9
Olmesartan 144689-24-7
Olmesartan medoxomil AT1 receptor antagonist 144689-63-4
Saralasin 34273-10-4
Telmisattan Angiotensin II receptor antagonist 144701-48-4
Tranilast Angiogenesis inhibitor 53902-12-8
Tranilast Sodium Antiallergic agent 104931-56-8
Valsartan Angiotensin II AT1 receptor antagonist 137862-53-4
ZD 7155 hydrochloride 146709-78-6
genes like me logo Genes that share compounds with AGTR1: view

Transcripts for AGTR1 Gene

Unigene Clusters for AGTR1 Gene

Angiotensin II receptor, type 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for AGTR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGTR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - - -
SP2:
SP3: -
SP4: - - - - -
SP5: -

Relevant External Links for AGTR1 Gene

GeneLoc Exon Structure for
AGTR1
ECgene alternative splicing isoforms for
AGTR1

Expression for AGTR1 Gene

mRNA expression in normal human tissues for AGTR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGTR1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x7.4), Liver (x7.0), Adipose - Visceral (Omentum) (x4.5), and Adrenal Gland (x4.1).

Protein differential expression in normal tissues from HIPED for AGTR1 Gene

This gene is overexpressed in Cerebrospinal fluid (61.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AGTR1 Gene



Protein tissue co-expression partners for AGTR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of AGTR1 Gene:

AGTR1

SOURCE GeneReport for Unigene cluster for AGTR1 Gene:

Hs.477887

mRNA Expression by UniProt/SwissProt for AGTR1 Gene:

P30556-AGTR1_HUMAN
Tissue specificity: Liver, lung, adrenal and adrenocortical adenomas.
genes like me logo Genes that share expression patterns with AGTR1: view

Primer Products

Orthologs for AGTR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGTR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGTR1 34 35
  • 99.72 (n)
mouse
(Mus musculus)
Mammalia Agtr1b 35
  • 93 (a)
OneToMany
Agtr1a 34 16 35
  • 87 (n)
dog
(Canis familiaris)
Mammalia AGTR1 34 35
  • 92.57 (n)
cow
(Bos Taurus)
Mammalia AGTR1 34 35
  • 91.18 (n)
oppossum
(Monodelphis domestica)
Mammalia AGTR1 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agtr1a 34
  • 86.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AGTR1 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGTR1 34 35
  • 73.91 (n)
lizard
(Anolis carolinensis)
Reptilia AGTR1 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agtr1 34
  • 65.66 (n)
African clawed frog
(Xenopus laevis)
Amphibia agtr1-A 34
zebrafish
(Danio rerio)
Actinopterygii agtr1a 35
  • 47 (a)
OneToMany
agtr1b 35
  • 45 (a)
OneToMany
Species where no ortholog for AGTR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGTR1 Gene

ENSEMBL:
Gene Tree for AGTR1 (if available)
TreeFam:
Gene Tree for AGTR1 (if available)

Paralogs for AGTR1 Gene

Variants for AGTR1 Gene

Sequence variations from dbSNP and Humsavar for AGTR1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs104893677 Renal tubular dysgenesis (RTD) [MIM:267430], Pathogenic 148,741,880(+) GGACA(C/T)GGCCA reference, missense
rs387906577 Pathogenic 148,741,145(+) AGTAT(-/T)CATCT reference, frameshift-variant
rs397514687 Pathogenic 148,741,411(+) TTGAT(C/T)GATAC reference, stop-gained
rs398122935 Pathogenic 148,741,286(+) ACTAT(A/G)GGCTG reference, stop-gained
rs5182 Benign 148,741,608(+) ACCCT(C/T)CCGAT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for AGTR1 Gene

Variant ID Type Subtype PubMed ID
dgv1417e212 CNV loss 25503493

Variation tolerance for AGTR1 Gene

Residual Variation Intolerance Score: 45.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGTR1 Gene

Human Gene Mutation Database (HGMD)
AGTR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGTR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGTR1 Gene

Disorders for AGTR1 Gene

MalaCards: The human disease database

(51) MalaCards diseases for AGTR1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
renal tubular dysgenesis
  • primitive renal tubule syndrome
hypertension, essential
  • hypertension, essential 3
renal tubular dysgenesis, agtr1-related
  • agtr1-related primitive renal tubule syndrome
cardiovascular disease risk factor )
  • coronary artery disease risk factor )
nephrosclerosis
  • renal sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search AGTR1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

AGTR1_HUMAN
  • Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269 PubMed:16116425}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for AGTR1 Gene

Bartter syndrome characterized by hypokalemic alkalosis,normal or hypercalciuria,normal magnesemia,early onset and hyperreninemia,hyperaldosteronism,hyperplasia of the juxtaglomerular apparatus

Relevant External Links for AGTR1

Genetic Association Database (GAD)
AGTR1
Human Genome Epidemiology (HuGE) Navigator
AGTR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGTR1
genes like me logo Genes that share disorders with AGTR1: view

Publications for AGTR1 Gene

  1. Association between the AGTR1 polymorphism +1166A&amp;gt;C and serum levels of high-sensitivity C-reactive protein. (PMID: 19026696) Suchankova P. … Ekman A. (Regul. Pept. 2009) 3 22 46 64
  2. Polymorphism in the angiotensin II type 1 receptor (AGTR1) is associated with age at diagnosis in pulmonary arterial hypertension. (PMID: 19332265) Chung W.K. … Morse J.H. (J. Heart Lung Transplant. 2009) 3 22 46 64
  3. The influence of six cardiovascular polymorphisms on a first event of ischemic heart disease is modified by sex and age. (PMID: 19779330) Plat A.W. … Kroon A.A. (Coron. Artery Dis. 2009) 3 22 46 64
  4. Screening the single nucleotide polymorphisms in patients with internal carotid artery stenosis by oligonucleotide-based custom DNA array. (PMID: 20066125) Nakai K. … Ogawa A. (Bioinform Biol Insights 2009) 3 22 46 64
  5. Genetic polymorphisms of the angiotensin II type 1 receptor gene and diastolic heart failure. (PMID: 19330904) Wu C.K. … Chiang F.T. (J. Hypertens. 2009) 3 22 46 64

Products for AGTR1 Gene

Sources for AGTR1 Gene

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