Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AGTR1 Gene

Aliases for AGTR1 Gene

  • Angiotensin II Receptor, Type 1 2 3
  • AT2R1 3 4 6
  • AGTR1B 3 4
  • AGTR1A 4 6
  • AT1AR 3 4
  • AT1BR 3 4
  • AT1 3 4
  • Type-1B Angiotensin II Receptor 3
  • Type-1 Angiotensin II Receptor 3
  • Angiotensin II Type-1 Receptor 4
  • Angiotensin Receptor 1B 2
  • AT2R1B 4
  • HAT1R 3
  • AG2S 3
  • AT1B 3
  • AT1R 3

External Ids for AGTR1 Gene

Previous HGNC Symbols for AGTR1 Gene

  • AGTR1B

Previous GeneCards Identifiers for AGTR1 Gene

  • GC03P145407
  • GC03P149300
  • GC03P149697
  • GC03P149736
  • GC03P149898
  • GC03P148415
  • GC03P145788

Summaries for AGTR1 Gene

Entrez Gene Summary for AGTR1 Gene

  • Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for AGTR1 Gene

AGTR1 (Angiotensin II Receptor, Type 1) is a Protein Coding gene. Diseases associated with AGTR1 include hypertension, essential and cardiovascular disease risk factor. Among its related pathways are Signaling by GPCR and p70S6K Signaling. GO annotations related to this gene include protein heterodimerization activity and acetyltransferase activator activity. An important paralog of this gene is ACKR3.

UniProtKB/Swiss-Prot for AGTR1 Gene

  • Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

Tocris Summary for AGTR1 Gene

  • The angiotensin1 receptors (AT1) are a member of the angiotensin group of G-protein-coupled receptors that also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung where they play a role in vasoconstriction, aldosterone and vasopressin release, salt and water retention, cell proliferation and migration and sympathetic stimulation. Most species express a single AT1 gene, but two related genes AT1A and AT1B are found in rodents. The human AT1 receptor gene has been localized to chromosome 3 (3q21-q25).

Gene Wiki entry for AGTR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGTR1 Gene

Genomics for AGTR1 Gene

Regulatory Elements for AGTR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AGTR1 Gene

148,697,784 bp from pter
148,743,008 bp from pter
45,225 bases
Plus strand

Genomic View for AGTR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGTR1 Gene

Proteins for AGTR1 Gene

  • Protein details for AGTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Type-1 angiotensin II receptor
    Protein Accession:
    Secondary Accessions:
    • Q13725
    • Q8TBK4

    Protein attributes for AGTR1 Gene

    359 amino acids
    Molecular mass:
    41061 Da
    Quaternary structure:
    • Interacts with MAS1 (Probable). Interacts with ARRB1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for AGTR1 Gene

neXtProt entry for AGTR1 Gene

Proteomics data for AGTR1 Gene at MOPED

Post-translational modifications for AGTR1 Gene

  • C-terminal Ser or Thr residues may be phosphorylated
  • Glycosylation at Asn4, Asn176, and Asn188
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for AGTR1 Gene

Domains for AGTR1 Gene

Gene Families for AGTR1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with AGTR1: view

Function for AGTR1 Gene

Molecular function for AGTR1 Gene

GENATLAS Biochemistry:
angiotensin II (type-1) receptor,G protein coupled receptor superfamily,including two subtypes AT1A and AT1B,major blood pressure regulator (activation of vascular growth),inhibiting adenylate cyclase,activating phospholipase C and A2,contributing in association with ACE to the risk of coronary disease,localized in the substantia nigra, the caudate nucleus and putamen (neuromodulator),blood vessels ,heart (conduction system) and kidney (renal medullary interstitial cells)
UniProtKB/Swiss-Prot Function:
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

Gene Ontology (GO) - Molecular Function for AGTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001596 angiotensin type I receptor activity IPI 1378723
GO:0004930 G-protein coupled receptor activity --
GO:0004945 angiotensin type II receptor activity IDA 15611106
GO:0005515 protein binding IPI 1378723
GO:0031711 bradykinin receptor binding IPI 10993080
genes like me logo Genes that share ontologies with AGTR1: view
genes like me logo Genes that share phenotypes with AGTR1: view

Animal Models for AGTR1 Gene

MGI Knock Outs for AGTR1:

Animal Model Products

CRISPR Products

miRNA for AGTR1 Gene

miRTarBase miRNAs that target AGTR1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGTR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for AGTR1 Gene

Localization for AGTR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGTR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for AGTR1 Gene COMPARTMENTS Subcellular localization image for AGTR1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for AGTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IC 1378723
GO:0016021 integral component of membrane NAS 8135787
genes like me logo Genes that share ontologies with AGTR1: view

Pathways for AGTR1 Gene

genes like me logo Genes that share pathways with AGTR1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for AGTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 17159080
GO:0001822 kidney development IMP 16116425
GO:0002018 renin-angiotensin regulation of aldosterone production NAS 17159080
GO:0002034 regulation of blood vessel size by renin-angiotensin IC 10993080
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin IC 1378723
genes like me logo Genes that share ontologies with AGTR1: view

Drugs for AGTR1 Gene

(12) Drugbank Compounds for AGTR1 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • 2-Butyl-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6 3749 Target antagonist approved, investigational
  • 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid
144689-63-4 Target antagonist approved, investigational
  • 4'-((1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid
144701-48-4 65999 Target antagonist approved, investigational
  • (S)-N-Valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl}-valine
137862-53-4 60846 Target antagonist approved, investigational
Azilsartan medoxomil
  • Azilsartan
147403-03-0 Target antagonist approved

(5) Tocris Compounds for AGTR1 Gene

Compound Action Cas Number
Candesartan AT1 receptor antagonist [139481-59-7]
EMD 66684 Potent, selective non-peptide AT1 antagonist [1216884-39-7]
Losartan potassium Selective, non-peptide AT1 antagonist [124750-99-8]
Olmesartan Potent AT1 antagonist; metabolite of Olmesartan medoxomil (Cat. No. 4620) [144689-24-7]
ZD 7155 hydrochloride Selective non-peptide AT1 antagonist [146709-78-6]

(17) ApexBio Compounds for AGTR1 Gene

Compound Action Cas Number
Angiotensin (1-7) Vasoconstriction peptide hormone [51833-78-4]
Angiotensin 1/2 (1-5) Vasoconstrictor [58442-64-1]
Angiotensin 1/2 (1-6) Vasoconstrictor [47896-63-9]
Angiotensin 1/2 + A (2 - 8) [51833-76-2]
Angiotensin II Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. [68521-88-0]
Angiotensin III (human, mouse) Aldosterone stimulator [13602-53-4]
AVE 0991 Agonist of angiotensin-(1-7) receptor [304462-19-9]
Azilsartan [147403-03-0]
Azilsartan Medoxomil Angiotensin II receptor type 1 antagonist [863031-21-4]
Candesartan Angiotensin II receptor 1 (AT1) antagonist [139481-59-7]
Eprosartan Mesylate [144143-96-4]
Irbesartan Angiotensin II inhibitor [138402-11-6]
LCZ696 [936623-90-4]
Losartan Potassium (DuP 753) Angiotensin AT1 receptor antagonist [124750-99-8]
Olmesartan medoxomil AT1 receptor antagonist [144689-63-4]
Telmisattan Angiotensin II receptor antagonist [144701-48-4]
Tranilast Angiogenesis inhibitor [53902-12-8]

(14) HMDB Compounds for AGTR1 Gene

(15) IUPHAR Ligand for AGTR1 Gene

Ligand Type Action Affinity Pubmed IDs
angiotensin I Agonist Full agonist 10
candesartan Antagonist Antagonist 9.7
EXP3174 Antagonist Antagonist 9.5
angiotensin-(1-7) Agonist Full agonist 9.4
angiotensin II Agonist Full agonist 9.3
[3H]valsartan Antagonist Antagonist 9
eprosartan Antagonist Antagonist 8.8
irbesartan Antagonist Antagonist 8.8
losartan Antagonist Antagonist 8.7
valsartan Antagonist Antagonist 8.61
angiotensin III Agonist Full agonist 8.5
telmisartan Antagonist Antagonist 8.4
olmesartan Antagonist Antagonist 8.1
L-162313 Agonist Full agonist 7.92
[3H]eprosartan Antagonist Antagonist

(140) Novoseek inferred chemical compound relationships for AGTR1 Gene

Compound -log(P) Hits PubMed IDs
losartan 93.9 118
candesartan 91.9 80
valsartan 88.9 54
pd123319 88.7 29
telmisartan 87.9 41

(5) PharmGKB related drug/compound annotations for AGTR1 Gene

Drug/compound Annotation
Ace Inhibitors, Plain Clinical Annotation
candesartan Clinical Annotation
captopril Clinical Annotation
losartan Clinical Annotation
perindopril Clinical Annotation
genes like me logo Genes that share compounds with AGTR1: view

Transcripts for AGTR1 Gene

Unigene Clusters for AGTR1 Gene

Angiotensin II receptor, type 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGTR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGTR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - - -
SP3: -
SP4: - - - - -
SP5: -

Relevant External Links for AGTR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AGTR1 Gene

mRNA expression in normal human tissues for AGTR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGTR1 Gene

This gene is overexpressed in Adipose - Subcutaneous (7.4), Liver (7.0), Adipose - Visceral (Omentum) (4.5), and Adrenal Gland (4.1).

Protein differential expression in normal tissues for AGTR1 Gene

This gene is overexpressed in Cerebrospinal fluid (61.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AGTR1 Gene

SOURCE GeneReport for Unigene cluster for AGTR1 Gene Hs.477887

mRNA Expression by UniProt/SwissProt for AGTR1 Gene

Tissue specificity: Liver, lung, adrenal and adrenocortical adenomas
genes like me logo Genes that share expressions with AGTR1: view

Expression partners for AGTR1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for AGTR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGTR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AGTR1 35
  • 91.18 (n)
  • 95.26 (a)
AGTR1 36
  • 95 (a)
(Canis familiaris)
Mammalia AGTR1 35
  • 92.57 (n)
  • 95.26 (a)
AGTR1 36
  • 95 (a)
(Mus musculus)
Mammalia Agtr1a 35
  • 87 (n)
  • 94.43 (a)
Agtr1b 16
Agtr1a 36
  • 94 (a)
Agtr1b 36
  • 93 (a)
(Pan troglodytes)
Mammalia AGTR1 35
  • 99.72 (n)
  • 99.72 (a)
AGTR1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Agtr1a 35
  • 86.35 (n)
  • 94.71 (a)
(Monodelphis domestica)
Mammalia AGTR1 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia AGTR1 36
  • 71 (a)
(Gallus gallus)
Aves AGTR1 35
  • 73.91 (n)
  • 75.77 (a)
AGTR1 36
  • 76 (a)
(Anolis carolinensis)
Reptilia AGTR1 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia agtr1 35
  • 65.66 (n)
  • 66.16 (a)
African clawed frog
(Xenopus laevis)
Amphibia agtr1-A 35
(Danio rerio)
Actinopterygii agtr1a 36
  • 47 (a)
agtr1b 36
  • 45 (a)
Species with no ortholog for AGTR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGTR1 Gene

Gene Tree for AGTR1 (if available)
Gene Tree for AGTR1 (if available)

Paralogs for AGTR1 Gene

Paralogs for AGTR1 Gene

genes like me logo Genes that share paralogs with AGTR1: view

Variants for AGTR1 Gene

Sequence variations from dbSNP and Humsavar for AGTR1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs5182 -- 148,741,608(+) ACCCT(C/T)CCGAT reference, synonymous-codon
rs5183 -- 148,742,097(+) GCACC(A/G)TGTTT reference, synonymous-codon
rs5184 -- 148,742,117(+) GTGAC(A/G)TGTTC utr-variant-3-prime
rs5185 -- 148,742,185(+) GCACT(G/T)CACTA utr-variant-3-prime
rs5186 other 148,742,201(+) TGAGC(A/C)TTAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for AGTR1 Gene

Variant ID Type Subtype PubMed ID
nsv877636 CNV Loss 21882294
nsv877637 CNV Gain 21882294
nsv877638 CNV Gain 21882294

Relevant External Links for AGTR1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGTR1 Gene

Disorders for AGTR1 Gene

(2) OMIM Diseases for AGTR1 Gene (106165)


  • Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269 PubMed:16116425}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) University of Copenhagen DISEASES for AGTR1 Gene

(95) Novoseek inferred disease relationships for AGTR1 Gene

Disease -log(P) Hits PubMed IDs
essential hypertension 76.6 56
diabetic nephropathies 73.2 36
renal disease 71 60
cardiovascular diseases 67.6 33
heart failure 66.4 84

Genatlas disease for AGTR1 Gene

Bartter syndrome characterized by hypokalemic alkalosis,normal or hypercalciuria,normal magnesemia,early onset and hyperreninemia,hyperaldosteronism,hyperplasia of the juxtaglomerular apparatus

Relevant External Links for AGTR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with AGTR1: view

Publications for AGTR1 Gene

  1. Novel subtype of human angiotensin II type 1 receptor: cDNA cloning and expression. (PMID: 8135787) Konishi H. … Fujisawa Y. (Biochem. Biophys. Res. Commun. 1994) 3 4 23
  2. Analysis of the postulated interaction between the angiotensin II sub-type 1 receptor gene A1166C polymorphism and the insertion/deletion polymorphism of the angiotensin converting enzyme gene on risk of myocardial infarction. (PMID: 11137090) Steeds R.P. … Samani N.J. (Atherosclerosis 2001) 3 23 48
  3. Type 1 angiotensin II receptors of adrenal tumors. (PMID: 7792812) Nawata H. … Ohe K. (Steroids 1995) 3 4 23
  4. Synergistic effect between apolipoprotein E and angiotensinogen gene polymorphisms in the risk for early myocardial infarction. (PMID: 11106322) Batalla A. … Coto E. (Clin. Chem. 2000) 3 23 48
  5. Polymorphisms of renin-angiotensin system genes in childhood IgA nephropathy. (PMID: 11354780) Maruyama K. … Yoshikawa N. (Pediatr. Nephrol. 2001) 3 23 48

Products for AGTR1 Gene

Sources for AGTR1 Gene

Back to Top