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Aliases for AGTR1 Gene

Aliases for AGTR1 Gene

  • Angiotensin II Receptor Type 1 2 3
  • Angiotensin II Receptor, Type 1 3 5
  • AGTR1B 3 4
  • AT1AR 3 4
  • AT1BR 3 4
  • AT2R1 3 4
  • AT1 3 4
  • Type-1B Angiotensin II Receptor 3
  • Angiotensin II Type-1 Receptor 4
  • Angiotensin Receptor 1B 2
  • AGTR1A 4
  • AT2R1B 4
  • HAT1R 3
  • AG2S 3
  • AT1B 3
  • AT1R 3

External Ids for AGTR1 Gene

Previous HGNC Symbols for AGTR1 Gene

  • AGTR1B

Previous GeneCards Identifiers for AGTR1 Gene

  • GC03P145407
  • GC03P149300
  • GC03P149697
  • GC03P149736
  • GC03P149898
  • GC03P148415
  • GC03P145788

Summaries for AGTR1 Gene

Entrez Gene Summary for AGTR1 Gene

  • Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for AGTR1 Gene

AGTR1 (Angiotensin II Receptor Type 1) is a Protein Coding gene. Diseases associated with AGTR1 include Renal Tubular Dysgenesis and Ataxia-Telangiectasia. Among its related pathways are Peptide ligand-binding receptors and Development Angiotensin activation of ERK. GO annotations related to this gene include G-protein coupled receptor activity and angiotensin type II receptor activity. An important paralog of this gene is ACKR3.

UniProtKB/Swiss-Prot for AGTR1 Gene

  • Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for AGTR1 Gene

  • The angiotensin1 receptor (AT1) is a member of the angiotensin group of G-protein-coupled receptors that also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung. AT1 receptors preferentially bind angiotensin II.

Gene Wiki entry for AGTR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGTR1 Gene

Genomics for AGTR1 Gene

Regulatory Elements for AGTR1 Gene

Enhancers for AGTR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AGTR1 on UCSC Golden Path with GeneCards custom track

Promoters for AGTR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AGTR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for AGTR1 Gene

Chromosome:
3
Start:
148,697,784 bp from pter
End:
148,743,008 bp from pter
Size:
45,225 bases
Orientation:
Plus strand

Genomic View for AGTR1 Gene

Genes around AGTR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGTR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGTR1 Gene

Proteins for AGTR1 Gene

  • Protein details for AGTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30556-AGTR1_HUMAN
    Recommended name:
    Type-1 angiotensin II receptor
    Protein Accession:
    P30556
    Secondary Accessions:
    • Q13725
    • Q8TBK4

    Protein attributes for AGTR1 Gene

    Size:
    359 amino acids
    Molecular mass:
    41061 Da
    Quaternary structure:
    • Interacts with MAS1 (Probable) (PubMed:15809376). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).

    Three dimensional structures from OCA and Proteopedia for AGTR1 Gene

neXtProt entry for AGTR1 Gene

Proteomics data for AGTR1 Gene at MOPED

Post-translational modifications for AGTR1 Gene

  • C-terminal Ser or Thr residues may be phosphorylated.
  • Glycosylation at Asn 4, Asn 176, and Asn 188
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for AGTR1 Gene

Domains & Families for AGTR1 Gene

Gene Families for AGTR1 Gene

Graphical View of Domain Structure for InterPro Entry

P30556

UniProtKB/Swiss-Prot:

AGTR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with AGTR1: view

Function for AGTR1 Gene

Molecular function for AGTR1 Gene

GENATLAS Biochemistry:
angiotensin II (type-1) receptor,G protein coupled receptor superfamily,including two subtypes AT1A and AT1B,major blood pressure regulator (activation of vascular growth),inhibiting adenylate cyclase,activating phospholipase C and A2,contributing in association with ACE to the risk of coronary disease,localized in the substantia nigra, the caudate nucleus and putamen (neuromodulator),blood vessels ,heart (conduction system) and kidney (renal medullary interstitial cells)
UniProtKB/Swiss-Prot Function:
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
genes like me logo Genes that share phenotypes with AGTR1: view

Human Phenotype Ontology for AGTR1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for AGTR1 Gene

MGI Knock Outs for AGTR1:

Animal Model Products

CRISPR Products

miRNA for AGTR1 Gene

miRTarBase miRNAs that target AGTR1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for AGTR1 Gene

Localization for AGTR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGTR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGTR1 Gene COMPARTMENTS Subcellular localization image for AGTR1 gene
Compartment Confidence
cytosol 5
plasma membrane 5
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
nucleus 2
endosome 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for AGTR1 Gene

Pathways & Interactions for AGTR1 Gene

genes like me logo Genes that share pathways with AGTR1: view

SIGNOR curated interactions for AGTR1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for AGTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002034 regulation of blood vessel size by renin-angiotensin IC 10993080
GO:0007186 G-protein coupled receptor signaling pathway IEA,IDA 1378723
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway NAS 17159080
GO:0007204 positive regulation of cytosolic calcium ion concentration IDA 1567413
GO:0007266 Rho protein signal transduction IDA 15611106
genes like me logo Genes that share ontologies with AGTR1: view

Drugs & Compounds for AGTR1 Gene

(133) Drugs for AGTR1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Candesartan Approved Pharma Antagonist, antagonist, Target Angiotensin II receptor 1 (AT1) antagonist 152
Irbesartan Approved, Investigational Pharma Antagonist, antagonist, Target Angiotensin II inhibitor 99
Losartan Approved Pharma Antagonist, antagonist, Target 277
Eprosartan Approved Pharma Antagonist, antagonist, Target 10
Olmesartan Approved, Investigational Pharma Antagonist, antagonist, Target 119

(59) Additional Compounds for AGTR1 Gene - From: Novoseek, IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]eprosartan
Antagonist
angiotensin I
Full agonist, Agonist
angiotensin-(1-7)
Full agonist, Agonist
L-162313
Full agonist, Agonist
4-Hydroxyvalsartan

(5) Tocris Compounds for AGTR1 Gene

Compound Action Cas Number
Azilsartan Potent AT1 receptor inverse agonist; antihypertensive 147403-03-0
EMD 66684 Potent, selective non-peptide AT1 antagonist 1216884-39-7
Losartan potassium Selective, non-peptide AT1 antagonist 124750-99-8
Valsartan High affinity, selective AT1 antagonist 137862-53-4
ZD 7155 hydrochloride Selective non-peptide AT1 antagonist 146709-78-6

(17) ApexBio Compounds for AGTR1 Gene

Compound Action Cas Number
Angiotensin (1-7) Vasoconstriction peptide hormone 51833-78-4
Angiotensin 1/2 (1-5) Vasoconstrictor 58442-64-1
Angiotensin 1/2 (1-6) Vasoconstrictor 47896-63-9
Angiotensin 1/2 + A (2 - 8) 51833-76-2
Angiotensin II Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. 68521-88-0
Angiotensin III (human, mouse) Aldosterone stimulator 13602-53-4
AVE 0991 Agonist of angiotensin-(1-7) receptor 304462-19-9
Azilsartan 147403-03-0
Azilsartan Medoxomil Angiotensin II receptor type 1 antagonist 863031-21-4
Candesartan Angiotensin II receptor 1 (AT1) antagonist 139481-59-7
Eprosartan Mesylate 144143-96-4
Irbesartan Angiotensin II inhibitor 138402-11-6
LCZ696 936623-90-4
Losartan Potassium (DuP 753) Angiotensin AT1 receptor antagonist 124750-99-8
Olmesartan medoxomil AT1 receptor antagonist 144689-63-4
Telmisattan Angiotensin II receptor antagonist 144701-48-4
Tranilast Angiogenesis inhibitor 53902-12-8
genes like me logo Genes that share compounds with AGTR1: view

Transcripts for AGTR1 Gene

Unigene Clusters for AGTR1 Gene

Angiotensin II receptor, type 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGTR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - - -
SP2:
SP3: -
SP4: - - - - -
SP5: -

Relevant External Links for AGTR1 Gene

GeneLoc Exon Structure for
AGTR1
ECgene alternative splicing isoforms for
AGTR1

Expression for AGTR1 Gene

mRNA expression in normal human tissues for AGTR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGTR1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x7.4), Liver (x7.0), Adipose - Visceral (Omentum) (x4.5), and Adrenal Gland (x4.1).

Protein differential expression in normal tissues from HIPED for AGTR1 Gene

This gene is overexpressed in Cerebrospinal fluid (61.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AGTR1 Gene



SOURCE GeneReport for Unigene cluster for AGTR1 Gene Hs.477887

mRNA Expression by UniProt/SwissProt for AGTR1 Gene

P30556-AGTR1_HUMAN
Tissue specificity: Liver, lung, adrenal and adrenocortical adenomas.
genes like me logo Genes that share expression patterns with AGTR1: view

Protein tissue co-expression partners for AGTR1 Gene

Orthologs for AGTR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGTR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AGTR1 35
  • 91.18 (n)
  • 95.26 (a)
AGTR1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGTR1 35
  • 92.57 (n)
  • 95.26 (a)
AGTR1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agtr1a 35
  • 87 (n)
  • 94.43 (a)
Agtr1a 16
Agtr1a 36
  • 94 (a)
OneToMany
Agtr1b 36
  • 93 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia AGTR1 35
  • 99.72 (n)
  • 99.72 (a)
AGTR1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agtr1a 35
  • 86.35 (n)
  • 94.71 (a)
oppossum
(Monodelphis domestica)
Mammalia AGTR1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGTR1 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGTR1 35
  • 73.91 (n)
  • 75.77 (a)
AGTR1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGTR1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agtr1 35
  • 65.66 (n)
  • 66.16 (a)
African clawed frog
(Xenopus laevis)
Amphibia agtr1-A 35
zebrafish
(Danio rerio)
Actinopterygii agtr1a 36
  • 47 (a)
OneToMany
agtr1b 36
  • 45 (a)
OneToMany
Species with no ortholog for AGTR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGTR1 Gene

ENSEMBL:
Gene Tree for AGTR1 (if available)
TreeFam:
Gene Tree for AGTR1 (if available)

Paralogs for AGTR1 Gene

Paralogs for AGTR1 Gene

genes like me logo Genes that share paralogs with AGTR1: view

Variants for AGTR1 Gene

Sequence variations from dbSNP and Humsavar for AGTR1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_011846 -
rs1064533 - 148,741,902(+) ATTTG(C/G/T)ATAGC reference, synonymous-codon, missense
rs1801021 - 148,742,041(+) TGAGC(A/C)CGCTT reference, missense
rs12721226 - 148,741,522(+) TGCCA(A/G)CTATA reference, missense
rs12721225 - 148,741,765(+) TTATG(G/T)CAATT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for AGTR1 Gene

Variant ID Type Subtype PubMed ID
nsv877636 CNV Loss 21882294
nsv877637 CNV Gain 21882294
nsv877638 CNV Gain 21882294

Variation tolerance for AGTR1 Gene

Residual Variation Intolerance Score: 45.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGTR1 Gene

Human Gene Mutation Database (HGMD)
AGTR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGTR1 Gene

Disorders for AGTR1 Gene

MalaCards: The human disease database

(55) MalaCards diseases for AGTR1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
renal tubular dysgenesis
  • primitive renal tubule syndrome
ataxia-telangiectasia
  • ataxia telangiectasia
spastic paraplegia 42, autosomal dominant
  • spg42
congenital cataracts, hearing loss, and neurodegeneration
  • cchlnd
hypertension, essential
  • hypertension, essential 3
- elite association - COSMIC cancer census association via MalaCards
Search AGTR1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

AGTR1_HUMAN
  • Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269 PubMed:16116425}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for AGTR1 Gene

Bartter syndrome characterized by hypokalemic alkalosis,normal or hypercalciuria,normal magnesemia,early onset and hyperreninemia,hyperaldosteronism,hyperplasia of the juxtaglomerular apparatus

Relevant External Links for AGTR1

Genetic Association Database (GAD)
AGTR1
Human Genome Epidemiology (HuGE) Navigator
AGTR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGTR1
genes like me logo Genes that share disorders with AGTR1: view

Publications for AGTR1 Gene

  1. Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor. (PMID: 1550596) Takayanagi R. … Nawata H. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 67
  2. A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones. (PMID: 19147680) Tagami T. … Naruse M. (Endocrinology 2009) 23 25 26
  3. Candesartan cilexetil in the treatment of chronic heart failure. (PMID: 19436650) Baguet J.P. … Neuder Y. (Vasc Health Risk Manag 2009) 23 25 26
  4. Candesartan: widening indications for this angiotensin II receptor blocker? (PMID: 19563275) Mendis B. … Page S.R. (Expert Opin Pharmacother 2009) 23 25 26
  5. Beyond the classic angiotensin-receptor-blocker profile. (PMID: 18580862) Kurtz T.W. (Nat Clin Pract Cardiovasc Med 2008) 23 25 26

Products for AGTR1 Gene

Sources for AGTR1 Gene

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