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Aliases for AGTPBP1 Gene

Aliases for AGTPBP1 Gene

  • ATP/GTP Binding Protein 1 2 3
  • CCP1 3 4 6
  • NNA1 3 4 6
  • Nervous System Nuclear Protein Induced By Axotomy Protein 1 Homolog 3 4
  • Tubulinyl-Tyr Carboxypeptidase 2 3
  • Cytosolic Carboxypeptidase 1 2 3
  • Tyrosine Carboxypeptidase 2 3
  • ATP/GTP-Binding Protein 1 3 4
  • Carboxypeptidase-Tubulin 2 3
  • Soluble Carboxypeptidase 2 3
  • KIAA1035 4 6
  • EC 3.4.17.- 4
  • EC 3.4.17 63

External Ids for AGTPBP1 Gene

Previous GeneCards Identifiers for AGTPBP1 Gene

  • GC09M079205
  • GC09M080014
  • GC09M081716
  • GC09M083618
  • GC09M085391
  • GC09M087351
  • GC09M088161
  • GC09M057985

Summaries for AGTPBP1 Gene

Entrez Gene Summary for AGTPBP1 Gene

  • NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif that was initially cloned from regenerating spinal cord neurons of the mouse.[supplied by OMIM, Jul 2002]

GeneCards Summary for AGTPBP1 Gene

AGTPBP1 (ATP/GTP Binding Protein 1) is a Protein Coding gene. Among its related pathways are Neuroscience. GO annotations related to this gene include tubulin binding and metallocarboxypeptidase activity. An important paralog of this gene is AGBL2.

UniProtKB/Swiss-Prot for AGTPBP1 Gene

  • Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGTPBP1 Gene

Genomics for AGTPBP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AGTPBP1 Gene

Start:
85,546,539 bp from pter
End:
85,742,029 bp from pter
Size:
195,491 bases
Orientation:
Minus strand

Genomic View for AGTPBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGTPBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGTPBP1 Gene

Proteins for AGTPBP1 Gene

  • Protein details for AGTPBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPW5-CBPC1_HUMAN
    Recommended name:
    Cytosolic carboxypeptidase 1
    Protein Accession:
    Q9UPW5
    Secondary Accessions:
    • B4DIT6
    • B4DRZ8
    • Q5VV80
    • Q63HM7
    • Q658P5
    • Q6P9D6
    • Q9H8U6
    • Q9H9W8
    • Q9NVK1

    Protein attributes for AGTPBP1 Gene

    Size:
    1226 amino acids
    Molecular mass:
    138448 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with MYLK.
    SequenceCaution:
    • Sequence=BAA82987.2; Type=Frameshift; Positions=10; Evidence={ECO:0000305}; Sequence=BAB14100.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14505.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG61460.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH56222.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW62697.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for AGTPBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGTPBP1 Gene

Proteomics data for AGTPBP1 Gene at MOPED

Post-translational modifications for AGTPBP1 Gene

  • Ubiquitination at Lys44
  • Modification sites at PhosphoSitePlus

Other Protein References for AGTPBP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for AGTPBP1 (Nna1)

Domains for AGTPBP1 Gene

Protein Domains for AGTPBP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UPW5

UniProtKB/Swiss-Prot:

CBPC1_HUMAN :
  • Q9UPW5
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with AGTPBP1: view

No data available for Gene Families for AGTPBP1 Gene

Function for AGTPBP1 Gene

Molecular function for AGTPBP1 Gene

UniProtKB/Swiss-Prot Function: Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.

Enzyme Numbers (IUBMB) for AGTPBP1 Gene

Gene Ontology (GO) - Molecular Function for AGTPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity ISS --
GO:0005488 binding --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0015631 tubulin binding ISS --
genes like me logo Genes that share ontologies with AGTPBP1: view
genes like me logo Genes that share phenotypes with AGTPBP1: view

Animal Model Products

CRISPR Products

miRNA for AGTPBP1 Gene

miRTarBase miRNAs that target AGTPBP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGTPBP1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for AGTPBP1 Gene

Localization for AGTPBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGTPBP1 Gene

Cytoplasm. Cytoplasm, cytosol. Nucleus. Mitochondrion. Note=Localizes in both the cytoplasm and nuclei of interphase and dividing cells. {ECO:0000269 PubMed:23085998}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGTPBP1 Gene COMPARTMENTS Subcellular localization image for AGTPBP1 gene
Compartment Confidence
cytosol 4
mitochondrion 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for AGTPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23085998
GO:0005737 cytoplasm IDA 23085998
GO:0005739 mitochondrion ISS --
GO:0005829 cytosol ISS --
genes like me logo Genes that share ontologies with AGTPBP1: view

Pathways for AGTPBP1 Gene

SuperPathways for AGTPBP1 Gene

Superpath Contained pathways
1 Neuroscience
genes like me logo Genes that share pathways with AGTPBP1: view

Pathways by source for AGTPBP1 Gene

1 Cell Signaling Technology pathway for AGTPBP1 Gene

Gene Ontology (GO) - Biological Process for AGTPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001754 eye photoreceptor cell differentiation ISS --
GO:0006508 proteolysis IEA --
GO:0007005 mitochondrion organization ISS --
GO:0007628 adult walking behavior --
GO:0021549 cerebellum development --
genes like me logo Genes that share ontologies with AGTPBP1: view

Transcripts for AGTPBP1 Gene

Unigene Clusters for AGTPBP1 Gene

ATP/GTP binding protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGTPBP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGTPBP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2: - - -
SP3:
SP4: -
SP5:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for AGTPBP1 Gene

GeneLoc Exon Structure for
AGTPBP1
ECgene alternative splicing isoforms for
AGTPBP1

Expression for AGTPBP1 Gene

mRNA expression in normal human tissues for AGTPBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGTPBP1 Gene

This gene is overexpressed in Whole Blood (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for AGTPBP1 Gene

SOURCE GeneReport for Unigene cluster for AGTPBP1 Gene Hs.719980

genes like me logo Genes that share expressions with AGTPBP1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AGTPBP1 Gene

Orthologs for AGTPBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGTPBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGTPBP1 35
  • 99.91 (n)
  • 99.83 (a)
AGTPBP1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AGTPBP1 35
  • 92.46 (n)
  • 95.05 (a)
AGTPBP1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGTPBP1 35
  • 92.48 (n)
  • 95.39 (a)
AGTPBP1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agtpbp1 35
  • 85.22 (n)
  • 91.36 (a)
Agtpbp1 16
Agtpbp1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGTPBP1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGTPBP1 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agtpbp1 35
  • 84.9 (n)
  • 90.77 (a)
chicken
(Gallus gallus)
Aves AGTPBP1 35
  • 76.45 (n)
  • 79.16 (a)
AGTPBP1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGTPBP1 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19750 35
tropical clawed frog
(Silurana tropicalis)
Amphibia agtpbp1 35
  • 71.5 (n)
  • 74.35 (a)
zebrafish
(Danio rerio)
Actinopterygii agtpbp1 35
  • 65.75 (n)
  • 69.86 (a)
agtpbp1 36
  • 63 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ccpp-1 36
  • 28 (a)
OneToMany
EEED8.6 37
  • 40 (a)
F56H1.5 37
  • 42 (a)
Species with no ortholog for AGTPBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGTPBP1 Gene

ENSEMBL:
Gene Tree for AGTPBP1 (if available)
TreeFam:
Gene Tree for AGTPBP1 (if available)

Paralogs for AGTPBP1 Gene

Paralogs for AGTPBP1 Gene

Selected SIMAP similar genes for AGTPBP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AGTPBP1: view

Variants for AGTPBP1 Gene

Sequence variations from dbSNP and Humsavar for AGTPBP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs589350 -- 85,637,167(+) CTCCC(A/G)AACAG intron-variant
rs590506 -- 85,629,422(-) TATAC(A/G)TACTG intron-variant
rs591464 -- 85,629,673(-) CGTAG(A/G)TGTAT intron-variant
rs594587 -- 85,630,403(-) aataa(A/C)taaat intron-variant
rs597360 -- 85,624,419(+) TAGAG(C/G)TGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGTPBP1 Gene

Variant ID Type Subtype PubMed ID
nsv436717 OTHER Inversion 17901297
nsv893524 CNV Loss 21882294
dgv2395e1 CNV Complex 17122850
nsv893525 CNV Gain 21882294
nsv893526 CNV Gain 21882294
dgv8256n71 CNV Loss 21882294
nsv524134 CNV Loss 19592680
dgv8257n71 CNV Loss 21882294
nsv893532 CNV Loss 21882294
nsv893533 CNV Loss 21882294
nsv6593 CNV Insertion 18451855
nsv831645 CNV Loss 17160897
nsv893534 CNV Loss 21882294
nsv525362 CNV Loss 19592680
esv2738683 CNV Deletion 23290073
nsv893535 CNV Gain 21882294
esv6066 CNV Gain 19470904

Relevant External Links for AGTPBP1 Gene

HapMap Linkage Disequilibrium report
AGTPBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGTPBP1 Gene

Disorders for AGTPBP1 Gene

Relevant External Links for AGTPBP1

Genetic Association Database (GAD)
AGTPBP1
Human Genome Epidemiology (HuGE) Navigator
AGTPBP1
genes like me logo Genes that share disorders with AGTPBP1: view

No data available for UniProtKB/Swiss-Prot for AGTPBP1 Gene

Publications for AGTPBP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4
  2. Regenerating motor neurons express Nna1, a novel ATP/GTP-binding protein related to zinc carboxypeptidases. (PMID: 11083920) Harris A. … Soares H.D. (Mol. Cell. Neurosci. 2000) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs). (PMID: 23085998) Rodriguez de la Vega Otazo M. … Bautista J.M. (FASEB J. 2013) 3 4
  5. Identification of CRM1-dependent Nuclear Export Cargos Using Quantitative Mass Spectrometry. (PMID: 23242554) Thakar K. … Kehlenbach R.H. (Mol. Cell Proteomics 2013) 3

Products for AGTPBP1 Gene

Sources for AGTPBP1 Gene

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