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Aliases for AGTPBP1 Gene

Aliases for AGTPBP1 Gene

  • ATP/GTP Binding Protein 1 2 3 5
  • Nervous System Nuclear Protein Induced By Axotomy Protein 1 Homolog 3 4
  • Tubulinyl-Tyr Carboxypeptidase 2 3
  • Cytosolic Carboxypeptidase 1 2 3
  • Tyrosine Carboxypeptidase 2 3
  • ATP/GTP-Binding Protein 1 3 4
  • Carboxypeptidase-Tubulin 2 3
  • Soluble Carboxypeptidase 2 3
  • CCP1 3 4
  • NNA1 3 4
  • EC 3.4.17.- 4
  • EC 3.4.17 61
  • KIAA1035 4

External Ids for AGTPBP1 Gene

Previous GeneCards Identifiers for AGTPBP1 Gene

  • GC09M079205
  • GC09M080014
  • GC09M081716
  • GC09M083618
  • GC09M085391
  • GC09M087351
  • GC09M088161
  • GC09M057985

Summaries for AGTPBP1 Gene

Entrez Gene Summary for AGTPBP1 Gene

  • NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif that was initially cloned from regenerating spinal cord neurons of the mouse.[supplied by OMIM, Jul 2002]

GeneCards Summary for AGTPBP1 Gene

AGTPBP1 (ATP/GTP Binding Protein 1) is a Protein Coding gene. Among its related pathways are Neuroscience. GO annotations related to this gene include binding and metallocarboxypeptidase activity. An important paralog of this gene is ENSG00000273540.

UniProtKB/Swiss-Prot for AGTPBP1 Gene

  • Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGTPBP1 Gene

Genomics for AGTPBP1 Gene

Regulatory Elements for AGTPBP1 Gene

Enhancers for AGTPBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around AGTPBP1 on UCSC Golden Path with GeneCards custom track

Promoters for AGTPBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for AGTPBP1 Gene

Chromosome:
9
Start:
85,546,539 bp from pter
End:
85,742,029 bp from pter
Size:
195,491 bases
Orientation:
Minus strand

Genomic View for AGTPBP1 Gene

Genes around AGTPBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGTPBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGTPBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGTPBP1 Gene

Proteins for AGTPBP1 Gene

  • Protein details for AGTPBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPW5-CBPC1_HUMAN
    Recommended name:
    Cytosolic carboxypeptidase 1
    Protein Accession:
    Q9UPW5
    Secondary Accessions:
    • B4DIT6
    • B4DRZ8
    • Q5VV80
    • Q63HM7
    • Q658P5
    • Q6P9D6
    • Q9H8U6
    • Q9H9W8
    • Q9NVK1

    Protein attributes for AGTPBP1 Gene

    Size:
    1226 amino acids
    Molecular mass:
    138448 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with MYLK.
    SequenceCaution:
    • Sequence=BAA82987.2; Type=Frameshift; Positions=10; Evidence={ECO:0000305}; Sequence=BAB14100.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14505.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG61460.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH56222.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW62697.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for AGTPBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGTPBP1 Gene

Post-translational modifications for AGTPBP1 Gene

  • Ubiquitination at Lys 44
  • Modification sites at PhosphoSitePlus

Other Protein References for AGTPBP1 Gene

Domains & Families for AGTPBP1 Gene

Protein Domains for AGTPBP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UPW5

UniProtKB/Swiss-Prot:

CBPC1_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with AGTPBP1: view

No data available for Gene Families for AGTPBP1 Gene

Function for AGTPBP1 Gene

Molecular function for AGTPBP1 Gene

UniProtKB/Swiss-Prot Function:
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.

Enzyme Numbers (IUBMB) for AGTPBP1 Gene

Gene Ontology (GO) - Molecular Function for AGTPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity IEA,ISS --
GO:0005515 protein binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0015631 tubulin binding IEA,ISS --
genes like me logo Genes that share ontologies with AGTPBP1: view
genes like me logo Genes that share phenotypes with AGTPBP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AGTPBP1

CRISPR Products

miRNA for AGTPBP1 Gene

miRTarBase miRNAs that target AGTPBP1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGTPBP1 Gene

Localization for AGTPBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGTPBP1 Gene

Cytoplasm. Cytoplasm, cytosol. Nucleus. Mitochondrion. Note=Localizes in both the cytoplasm and nuclei of interphase and dividing cells. {ECO:0000269 PubMed:23085998}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGTPBP1 Gene COMPARTMENTS Subcellular localization image for AGTPBP1 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 4
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for AGTPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 23085998
GO:0005737 cytoplasm IEA,IDA 23085998
GO:0005739 mitochondrion IEA,ISS --
GO:0005829 cytosol IEA,ISS --
genes like me logo Genes that share ontologies with AGTPBP1: view

Pathways & Interactions for AGTPBP1 Gene

SuperPathways for AGTPBP1 Gene

Superpath Contained pathways
1 Neuroscience
genes like me logo Genes that share pathways with AGTPBP1: view

Pathways by source for AGTPBP1 Gene

1 Cell Signaling Technology pathway for AGTPBP1 Gene

Gene Ontology (GO) - Biological Process for AGTPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001754 eye photoreceptor cell differentiation ISS --
GO:0006508 proteolysis IEA --
GO:0007005 mitochondrion organization IEA,ISS --
GO:0007628 adult walking behavior IEA --
GO:0021549 cerebellum development IEA --
genes like me logo Genes that share ontologies with AGTPBP1: view

No data available for SIGNOR curated interactions for AGTPBP1 Gene

Drugs & Compounds for AGTPBP1 Gene

No Compound Related Data Available

Transcripts for AGTPBP1 Gene

Unigene Clusters for AGTPBP1 Gene

ATP/GTP binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGTPBP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2: - - -
SP3:
SP4: -
SP5:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for AGTPBP1 Gene

GeneLoc Exon Structure for
AGTPBP1
ECgene alternative splicing isoforms for
AGTPBP1

Expression for AGTPBP1 Gene

mRNA expression in normal human tissues for AGTPBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGTPBP1 Gene

This gene is overexpressed in Whole Blood (x7.4).

Protein differential expression in normal tissues from HIPED for AGTPBP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.7), Monocytes (13.4), Fetal Brain (12.5), Platelet (10.0), and Retina (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AGTPBP1 Gene



Protein tissue co-expression partners for AGTPBP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of AGTPBP1 Gene:

AGTPBP1

SOURCE GeneReport for Unigene cluster for AGTPBP1 Gene:

Hs.719980
genes like me logo Genes that share expression patterns with AGTPBP1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for AGTPBP1 Gene

Orthologs for AGTPBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGTPBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AGTPBP1 34
  • 92.46 (n)
  • 95.05 (a)
AGTPBP1 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGTPBP1 34
  • 92.48 (n)
  • 95.39 (a)
AGTPBP1 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agtpbp1 34
  • 85.22 (n)
  • 91.36 (a)
Agtpbp1 16
Agtpbp1 35
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AGTPBP1 34
  • 99.91 (n)
  • 99.83 (a)
AGTPBP1 35
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agtpbp1 34
  • 84.9 (n)
  • 90.77 (a)
oppossum
(Monodelphis domestica)
Mammalia AGTPBP1 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGTPBP1 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGTPBP1 34
  • 76.45 (n)
  • 79.16 (a)
AGTPBP1 35
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGTPBP1 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agtpbp1 34
  • 71.5 (n)
  • 74.35 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19750 34
zebrafish
(Danio rerio)
Actinopterygii agtpbp1 34
  • 65.75 (n)
  • 69.86 (a)
agtpbp1 35
  • 63 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea EEED8.6 36
  • 40 (a)
F56H1.5 36
  • 42 (a)
ccpp-1 35
  • 28 (a)
OneToMany
Species where no ortholog for AGTPBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGTPBP1 Gene

ENSEMBL:
Gene Tree for AGTPBP1 (if available)
TreeFam:
Gene Tree for AGTPBP1 (if available)

Paralogs for AGTPBP1 Gene

Paralogs for AGTPBP1 Gene

(2) SIMAP similar genes for AGTPBP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AGTPBP1: view

Variants for AGTPBP1 Gene

Sequence variations from dbSNP and Humsavar for AGTPBP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_036884 A colorectal cancer sample
rs7853892 -- 85,599,315(+) ACGGA(C/T)ATACA intron-variant
rs7856214 -- 85,648,673(+) tgggc(A/G)tggtg intron-variant
rs7856595 -- 85,561,436(+) aagac(A/G)aatag intron-variant
rs7857819 -- 85,579,267(+) ATTTT(A/G)AATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGTPBP1 Gene

Variant ID Type Subtype PubMed ID
esv2738683 CNV deletion 23290073
esv2759702 CNV loss 17122850
esv3620941 CNV loss 21293372
esv6066 CNV gain 19470904
nsv1051546 CNV gain 25217958
nsv436717 OTHER inversion 17901297
nsv476058 CNV novel sequence insertion 20440878
nsv477830 CNV novel sequence insertion 20440878
nsv524134 CNV loss 19592680
nsv525362 CNV loss 19592680
nsv614774 CNV gain 21841781
nsv6593 CNV insertion 18451855
nsv831645 CNV loss 17160897

Variation tolerance for AGTPBP1 Gene

Residual Variation Intolerance Score: 7.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.93; 74.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGTPBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGTPBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGTPBP1 Gene

Disorders for AGTPBP1 Gene

Relevant External Links for AGTPBP1

Genetic Association Database (GAD)
AGTPBP1
Human Genome Epidemiology (HuGE) Navigator
AGTPBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGTPBP1

No disorders were found for AGTPBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGTPBP1 Gene

Publications for AGTPBP1 Gene

  1. Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs). (PMID: 23085998) Rodriguez de la Vega Otazo M. … Bautista J.M. (FASEB J. 2013) 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. Regenerating motor neurons express Nna1, a novel ATP/GTP-binding protein related to zinc carboxypeptidases. (PMID: 11083920) Harris A. … Soares H.D. (Mol. Cell. Neurosci. 2000) 2 3 65
  4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4 65
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 65

Products for AGTPBP1 Gene

Sources for AGTPBP1 Gene

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