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Aliases for AGT Gene

Aliases for AGT Gene

  • Angiotensinogen 2 3
  • Angiotensinogen (Serpin Peptidase Inhibitor, Clade A, Member 8) 3 5
  • Serpin Peptidase Inhibitor, Clade A, Member 8 2 3
  • Serpin A8 3 4
  • SERPINA8 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor 3
  • Alpha-1 Antiproteinase, Antitrypsin 3
  • Alpha-1 Antiproteinase 2
  • Pre-Angiotensinogen 3
  • Angiotensin II 3
  • Angiotensin I 3
  • Antitrypsin 2
  • ANHU 3

External Ids for AGT Gene

Previous HGNC Symbols for AGT Gene

  • SERPINA8

Previous GeneCards Identifiers for AGT Gene

  • GC01M229315
  • GC01M226566
  • GC01M227311
  • GC01M227873
  • GC01M227145
  • GC01M228904
  • GC01M230838
  • GC01M201323

Summaries for AGT Gene

Entrez Gene Summary for AGT Gene

  • The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGT Gene

AGT (Angiotensinogen) is a Protein Coding gene. Diseases associated with AGT include renal tubular dysgenesis and hypertension, essential. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include growth factor activity and serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for AGT Gene

  • Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.

  • Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.

  • Angiotensin-3: stimulates aldosterone release.

  • Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

Gene Wiki entry for AGT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGT Gene

Genomics for AGT Gene

Regulatory Elements for AGT Gene

Promoters for AGT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AGT on UCSC Golden Path with GeneCards custom track

Genomic Location for AGT Gene

Chromosome:
1
Start:
230,702,523 bp from pter
End:
230,714,590 bp from pter
Size:
12,068 bases
Orientation:
Minus strand

Genomic View for AGT Gene

Genes around AGT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGT Gene

Proteins for AGT Gene

  • Protein details for AGT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01019-ANGT_HUMAN
    Recommended name:
    Angiotensinogen
    Protein Accession:
    P01019
    Secondary Accessions:
    • Q16358
    • Q16359
    • Q96F91

    Protein attributes for AGT Gene

    Size:
    485 amino acids
    Molecular mass:
    53154 Da
    Quaternary structure:
    • During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg.

    Three dimensional structures from OCA and Proteopedia for AGT Gene

neXtProt entry for AGT Gene

Proteomics data for AGT Gene at MOPED

Post-translational modifications for AGT Gene

  • Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.
  • In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin).
  • The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.
  • Glycosylation at Asn 47, Asn 170, Asn 304, and Asn 328
  • Modification sites at PhosphoSitePlus

Other Protein References for AGT Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for AGT (Serpin A8/Angiotensinogen)

No data available for DME Specific Peptides for AGT Gene

Domains & Families for AGT Gene

Protein Domains for AGT Gene

Graphical View of Domain Structure for InterPro Entry

P01019

UniProtKB/Swiss-Prot:

ANGT_HUMAN :
  • Belongs to the serpin family.
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with AGT: view

Function for AGT Gene

Molecular function for AGT Gene

GENATLAS Biochemistry:
angiotensinogen,glycoprotein precursor of angiotensin II,expressed in the liver
UniProtKB/Swiss-Prot Function:
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
UniProtKB/Swiss-Prot Function:
Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
UniProtKB/Swiss-Prot Function:
Angiotensin-3: stimulates aldosterone release.
UniProtKB/Swiss-Prot Function:
Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

Gene Ontology (GO) - Molecular Function for AGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16237761
GO:0031703 type 2 angiotensin receptor binding IEA,IPI 10406457
genes like me logo Genes that share ontologies with AGT: view
genes like me logo Genes that share phenotypes with AGT: view

Human Phenotype Ontology for AGT Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for AGT Gene

MGI Knock Outs for AGT:

Animal Model Products

miRNA for AGT Gene

miRTarBase miRNAs that target AGT

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for AGT Gene

Localization for AGT Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGT Gene COMPARTMENTS Subcellular localization image for AGT gene
Compartment Confidence
extracellular 5
cytosol 2
endoplasmic reticulum 2
lysosome 2
mitochondrion 2
nucleus 2
plasma membrane 2
vacuole 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for AGT Gene

Pathways & Interactions for AGT Gene

genes like me logo Genes that share pathways with AGT: view

SIGNOR curated interactions for AGT Gene

Activates:

Gene Ontology (GO) - Biological Process for AGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production TAS 17906677
GO:0001822 kidney development IMP 16116425
GO:0001974 blood vessel remodeling TAS 10406457
GO:0002016 regulation of blood volume by renin-angiotensin NAS 17159080
GO:0002018 renin-angiotensin regulation of aldosterone production IEA,NAS 17159080
genes like me logo Genes that share ontologies with AGT: view

Drugs & Compounds for AGT Gene

(82) Drugs for AGT Gene - From: Novoseek, PharmGKB, ApexBio, HMDB, DrugBank, DGIdb, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lisinopril Approved, Investigational Pharma ACE inhibitor 116
Amlodipine Approved Pharma Calcium channel blocker 449
Atenolol Approved Pharma Antagonist 99
Benazepril Approved, Investigational Pharma 45
Irbesartan Approved, Investigational Pharma Antagonist Angiotensin II inhibitor 97

(59) Additional Compounds for AGT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with AGT: view

Transcripts for AGT Gene

mRNA/cDNA for AGT Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(619) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AGT Gene

Angiotensinogen (serpin peptidase inhibitor, clade A, member 8):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGT Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2:

Relevant External Links for AGT Gene

GeneLoc Exon Structure for
AGT
ECgene alternative splicing isoforms for
AGT

Expression for AGT Gene

mRNA expression in normal human tissues for AGT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGT Gene

This gene is overexpressed in Liver (x23.4).

Protein differential expression in normal tissues from HIPED for AGT Gene

This gene is overexpressed in Serum (18.0), Synovial fluid (9.7), Plasma (7.8), Cerebrospinal fluid (7.0), and Monocytes (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGT Gene



SOURCE GeneReport for Unigene cluster for AGT Gene Hs.19383

mRNA Expression by UniProt/SwissProt for AGT Gene

P01019-ANGT_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.
genes like me logo Genes that share expression patterns with AGT: view

Protein tissue co-expression partners for AGT Gene

Primer Products

In Situ Assay Products

Orthologs for AGT Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGT 35
  • 98.63 (n)
  • 98.97 (a)
REN 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AGT 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGT 36
  • 67 (a)
OneToOne
AGT 35
  • 77.03 (n)
  • 67.44 (a)
mouse
(Mus musculus)
Mammalia Agt 16
Agt 36
  • 60 (a)
OneToOne
Agt 35
  • 71.15 (n)
  • 61.13 (a)
oppossum
(Monodelphis domestica)
Mammalia AGT 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGT 36
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agt 35
  • 72.89 (n)
  • 64.54 (a)
chicken
(Gallus gallus)
Aves AGT 35
  • 52.77 (n)
  • 39.96 (a)
AGT 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGT 36
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agt 35
  • 48.08 (n)
  • 34.39 (a)
zebrafish
(Danio rerio)
Actinopterygii agt 36
  • 26 (a)
OneToOne
agt 35
  • 44.8 (n)
  • 30.05 (a)
Species with no ortholog for AGT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGT Gene

ENSEMBL:
Gene Tree for AGT (if available)
TreeFam:
Gene Tree for AGT (if available)

Paralogs for AGT Gene

No data available for Paralogs for AGT Gene

Variants for AGT Gene

Sequence variations from dbSNP and Humsavar for AGT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4762 - 230,710,231(-) GTCCA(C/T)GGTGG reference, missense
VAR_007094 -
rs5041 - 230,710,120(-) AGAAC(G/T)GGATG reference, missense
rs699 - 230,710,048(-) CCTGA(C/T)GGGAG reference, missense
rs56073403 - 230,710,009(+) GGACG(C/T)AGGTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for AGT Gene

Variant ID Type Subtype PubMed ID
nsv832836 CNV Loss 17160897
esv2657518 CNV Deletion 23128226

Variation tolerance for AGT Gene

Residual Variation Intolerance Score: 90.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGT Gene

HapMap Linkage Disequilibrium report
AGT
Human Gene Mutation Database (HGMD)
AGT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGT Gene

Disorders for AGT Gene

MalaCards: The human disease database

(47) MalaCards diseases for AGT Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
renal tubular dysgenesis
  • primitive renal tubule syndrome
hypertension, essential
  • hypertension, essential 3
renal tubular dysgenesis of genetic origin
renal tubular dysgenesis, agt-related
  • agt-related primitive renal tubule syndrome
fibromuscular dysplasia
  • frontometaphyseal dysplasia
- elite association - COSMIC cancer census association via MalaCards
Search AGT in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ANGT_HUMAN
  • Essential hypertension (EHT) [MIM:145500]: A condition in which blood pressure is consistently higher than normal with no identifiable cause. {ECO:0000269 PubMed:1394429, ECO:0000269 PubMed:8513325}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269 PubMed:16116425}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for AGT Gene

hypertension associated with molecular variants of angiotensinogen,including pregnancy-induced hypertension (preeclampsia),also increased risk of coronary heart disease (T174M and M235 variants),excluded at least in a population of Australian Anglo-Celtic Caucasians

Relevant External Links for AGT

Genetic Association Database (GAD)
AGT
Human Genome Epidemiology (HuGE) Navigator
AGT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGT
genes like me logo Genes that share disorders with AGT: view

Publications for AGT Gene

  1. Primary structure of human preangiotensinogen deduced from the cloned cDNA sequence. (PMID: 6089875) Kageyama R. … Nakanishi S. (Biochemistry 1984) 2 3 4 67
  2. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3
  3. Angiotensinogen promoter variants influence gene expression in human kidney and visceral adipose tissue. (PMID: 19536167) Sarzani R. … Rappelli A. (J Hum Hypertens 2010) 3 23
  4. Genotype-phenotype analysis of angiotensinogen polymorphisms and essential hypertension: the importance of haplotypes. (PMID: 19770777) Watkins W.S. … Jorde L.B. (J. Hypertens. 2010) 3 23
  5. JunD and HIF-1alpha mediate transcriptional activation of angiotensinogen by TGF-beta1 in human lung fibroblasts. (PMID: 19211927) Abdul-Hafez A. … Uhal B.D. (FASEB J. 2009) 3 23

Products for AGT Gene

Sources for AGT Gene

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