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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AGT Gene

protein-coding GIFtS: 68
GCID: GC01M230838

angiotensinogen (serpin peptidase inhibitor, clade A, member...

(Previous symbol: SERPINA8)

Explore 158 diseases affiliated with
AGT via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Angiotensinogen (Serpin Peptidase Inhibitor, Clade A, Member 8)¹ ²		Angiotensin I²
SERPINA8¹ ² ³ ⁵		Angiotensin II²
Serpin A8² ³		Angiotensinogen¹
ANHU²		Pre-Angiotensinogen¹
Alpha-1 Antiproteinase, Antitrypsin²		Serine (Or Cysteine) Proteinase Inhibitor²

External Ids:	HGNC: 333¹	Entrez Gene: 183²	Ensembl: ENSG00000135744⁷	OMIM: 106150⁵	UniProtKB: P01019³

Export aliases for AGT gene to outside databases

Previous GC identifers: GC01M229315 GC01M226566 GC01M227311 GC01M227873 GC01M227145 GC01M228904 GC01M201323

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AGT:

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is

cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then

cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The

protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia.

Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular

dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with

non-familial structural atrial fibrillation, and inflammatory bowel disease. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019

Function: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid

and electrolyte homeostasis

Function: Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac

contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water

absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete

aldosterone

Function: Angiotensin-3: stimulates aldosterone release

Function: Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and

antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide

from platelets (By similarity)

summary for AGT:

The angiotensin family of peptides is important in the regulation of blood volume, vascular resistance and

electrolyte balance. Angiotensin II, the main peptide of the renin-angiotensin system, produces a variety of

physiological effects. It is produced in a cascade whereby the precursor peptide angiotensinogen is cleaved

to produce renin and angiotensin I. Angiotensin-converting enzyme then acts on angiotensin I to yield the

octapeptide angiotensin II, and further processing generates angiotensins III and IV. These peptides act on

three angiotensin receptor subtypes, AT1, AT2 and AT4, the properties of which are summarized below. The

actions of angiotensin II are primarily mediated by AT1, whereas AT2 preferentially binds angiotensin III

and AT4 is selective for angiotensin IV.

Gene Wiki entry for AGT (Angiotensin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AGT gene promoter:
PPAR-gamma1 Sp1 STAT3 PPAR-gamma2 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): AGT promoter sequence

Search SABiosciences Chromatin IP Primers for AGT

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGT

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.2 Ensembl cytogenetic band: 1q42.2 HGNC cytogenetic band: 1q42.2

AGT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGT gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M230838: view genomic region (about GC identifiers)

Start:	230,838,269 bp from pter	End:	230,850,336 bp from pter
Size:	12,068 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019 (See protein sequence)

Recommended Name: Angiotensinogen precursor

Size: 485 amino acids; 53154 Da

Subunit: During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex

(probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg

Subcellular location: Secreted

Caution: It is uncertain whether Met-1 or Met-10 is the initiator

6/8 PDB 3D structures from and Proteopedia for AGT (see all 8):

1N9U (3D)

1N9V (3D)

2JP8 (3D)

2WXW (3D)

2X0B (3D)

4AA1 (3D)

Secondary accessions: Q16358 Q16359 Q96F91

Explore the universe of human proteins at neXtProt for AGT: NX_P01019

Post-translational modifications:

Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide

form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2

receptor¹

In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1

is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active

peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3,

angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce

angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from

angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin)¹

The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized

disulfide-bonded form, which preferentially interacts with receptor-bound renin¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P01019

AGT Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000020.1

ENSEMBL proteins:

ENSP00000355627

Reactome Protein details: P01019
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals AGT Proteins Novus Biologicals AGT Lysates
	Sino Biological Recombinant Protein for AGT
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for AGT

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	ISS	--
GO:0005625	soluble fraction	--	--
GO:0044444	cytoplasmic part	IEA	--

AGT for ontologies About GeneDecksing

AGT Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of AGT
	R&D Systems Antibodies for AGT (Serpin A8/Angiotensinogen)
	OriGene Antibodies (see all 5): AGT OriGene Custom Antibody Services for AGT
	GenScript Custom Superior Antibodies Services for AGT
	Novus Biologicals AGT Antibodies
	Abcam antibodies for AGT
	Uscn Antibodies for AGT
	ThermoFisher Antibody for AGT

Assay Products for AGT:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for AGT (Serpin A8/Angiotensinogen)
	GenScript Custom Assay Services for AGT
	Enzo Life Sciences assays for AGT
	Uscn ELISAs and CLIAs for AGT

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AGT for domains About GeneDecksing

4 InterPro domains/families:

IPR023795 Protease_inhib_I4_serpin_CS

IPR023796 Serpin_dom

IPR000227 Angiotensngn

IPR000215 Serpin_fam

Graphical View of Domain Structure for InterPro Entry P01019

ProtoNet protein and cluster: P01019

2 Blocks protein families:

IPB000215 Serpin

IPB000227 Angiotensinogen signature

UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019

Similarity: Belongs to the serpin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019

Function: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid

and electrolyte homeostasis

Function: Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac

contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water

absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete

aldosterone

Function: Angiotensin-3: stimulates aldosterone release

Function: Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and

antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide

from platelets (By similarity)

Genatlas biochemistry entry for AGT:

angiotensinogen,glycoprotein precursor of angiotensin II,expressed in the liver

Summary:

During embryonic development, AGT as signaling molecule

affects the following cells: Ureteric Bud Tip Cells in Ureteric Bud, Vascular Smooth Muscle Cells in Endocardium (see all 4).

miRNA Products:		OriGene 3'-UTR Clone: AGT Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AGT
		1 QIAGEN miScript miRNA Assays for microRNA that regulate AGT:
		hsa-miR-767-3p
		SwitchGear 3'UTR luciferase reporter plasmid: AGT 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AGT (see all 7) OriGene shRNA RFP: AGT OriGene siRNA: AGT
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGT

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for AGT

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGT (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGT (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: AGT (NM_000029)
		Sino Biological Human cDNA Clone for AGT
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGT

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for AGT
		Search LifeMap BioReagents cell lines for AGT

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGT

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004867	serine-type endopeptidase inhibitor activity	IBA	--
GO:0005179	hormone activity	ISS	--
GO:0008083	growth factor activity	TAS	10406457
GO:0010698	acetyltransferase activator activity	IDA	18971559
GO:0031701	angiotensin receptor binding	--	--

AGT for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for AGT: Agt^tm1Ii Agt^tm1Afu Agt^tm1Unc
     12 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Agt):

adipose tissue	behavior/neurological	cardiovascular system	growth/size	homeostasis/metabolism
immune system	liver/biliary system	mortality/aging	muscle	nervous system
renal/urinary system	reproductive system

AGT for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75			G alpha (i) signalling events	0.44

Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	1.00			Fatty acid, triacylglycerol, and ketone body metabolism	0.52
	PPARA Activates Gene Expression	0.74

Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics	1.00			ACE Inhibitor Pathway	0.85
	ACE Inhibitor Pathway, Pharmacodynamics	1.00

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AGT

	Renin-Angiotensin Pathway
	JAK-STAT Pathway
	NFAT and Cardiac Hypertrophy

4 GeneGo (Thomson Reuters) Pathways for AGT

	Development Angiotensin activation of ERK
	Development Angiotensin signaling via beta-Arrestin
	Cell adhesion Integrin inside-out signaling
	Development Angiotensin signaling via PYK2

5 BioSystems Pathways for AGT

	MicroRNAs in cardiomyocyte hypertrophy
	ACE Inhibitor Pathway
	Adipogenesis
	Monoamine Transport
	Signaling events mediated by PRL

5/18 Reactome Pathways for AGT (see all 18)

	Metabolism
	Fatty acid, triacylglycerol, and ketone body metabolism
	Metabolism of Angiotensinogen to Angiotensins
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Expression of AGT

2 PharmGKB Pathways for AGT

	ACE Inhibitor Pathway, Pharmacodynamics
	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for AGT):

Renin-angiotensin system

AGT for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for AGT

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/27 Interacting proteins for AGT (P01019^{2, 3} ENSP00000355627⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AGTR2	P50052³, ENSP00000360973⁴	I2D: score=2 STRING: ENSP00000360973
ACE2	Q9BYF1³, ENSP00000252519⁴	I2D: score=1 STRING: ENSP00000252519
AGTR1	P30556³, ENSP00000273430⁴	I2D: score=1 STRING: ENSP00000273430
DNPEP	Q9ULA0³, ENSP00000273075⁴	I2D: score=1 STRING: ENSP00000273075
ENPEP	Q07075³, ENSP00000265162⁴	I2D: score=1 STRING: ENSP00000265162

About this table

Gene Ontology (GO): 5/99 biological process terms (GO ID links to tree view) (see all 99): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001543	ovarian follicle rupture	IEA	--
GO:0001558	regulation of cell growth	NAS	17159080
GO:0001568	blood vessel development	IEA	--
GO:0001658	branching involved in ureteric bud morphogenesis	IEA	--
GO:0001819	positive regulation of cytokine production	TAS	17906677

AGT for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

AGT for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for AGT available from Tocris Bioscience About this table

Compound	Action	CAS #
EMD 66684	Potent, selective non-peptide AT1 antagonist	[187683-79-0]
Flupirtine maleate	K+ channel activator	[75507-68-5]
ZD 7155 hydrochloride	Selective non-peptide AT1 antagonist	[146709-78-6]
PD 123319 ditrifluoroacetate	Potent, selective non-peptide AT2 antagonist	[130663-39-7]
Y-27632 dihydrochloride	Selective p160ROCK inhibitor	[146986-50-7]

3 HMDB Compounds for AGT About this table

Compound	Synonyms	CAS #	PubMed Ids
Atorvastatin	Atorvastatin acid (see all 4)	134523-00-5	--
Lisinopril	Acerbon (see all 34)	83915-83-7	--
Simvastatin	(+)-Simvastatin (see all 28)	79902-63-9	--

10/128 Novoseek chemical compound relationships for AGT gene (see all 128) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
losartan	80.3	81	8160786 (6), 8491505 (4), 11256235 (4), 15194475 (3) (see all 47)
pd123319	78.1	22	17060512 (3), 9510088 (2), 10419063 (2), 11230289 (2) (see all 12)
chymostatin	67.8	7	8695029 (1), 12714330 (1), 9793075 (1), 8024040 (1)
cv 11974	60.7	5	17487826 (2), 11034947 (1), 11108152 (1)
o6-methylguanine	60.3	25	14615965 (3), 1423888 (3), 2328502 (2), 7519972 (2) (see all 9)
remikiren	59	5	7796503 (2), 9440700 (1)
aliskiren	57.8	2	11799102 (1)
ang ii	55.9	5	17504233 (3), 12194787 (1)
kn 93	55.9	3	8903426 (2), 14645496 (1)
sele	55.6	2	11341749 (1), 15076187 (1)

1 PharmGKB related drug/compound annotation for AGT gene

Drug/compound	PharmGKB Annotation
"Antiinflammatory agents, non-steroids"	CA

About this table

Search CenterWatch for drugs/clinical trials and news about AGT / ANGT

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AGT gene:

NM_000029.3

Unigene Cluster for AGT:

Angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

Hs.19383 [show with all ESTs]

Unigene Representative Sequence: NM_000029

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000366667(uc001hty.4 uc009xff.3)

miRNA Products:		OriGene 3'-UTR Clone: AGT Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AGT
		1 QIAGEN miScript miRNA Assays for microRNA that regulate AGT:
		hsa-miR-767-3p
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AGT (see all 7) OriGene shRNA RFP: AGT OriGene siRNA: AGT
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		GenScript: all cDNA clones in your preferred vector: AGT (NM_000029)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGT

Additional cDNA sequence:

AB209769.1 AK222798.1 AK222815.1 AK293507.1 AK303755.1 AK307978.1 AK312291.1 BC011519.1

BT006851.1 K02215.1 M69110.1

21 DOTS entries:

DT.95161596 DT.100882586 DT.320302 DT.100882604 DT.100882590 DT.100882596 DT.100882597 DT.100882601

DT.121461228 DT.95161591 DT.100882579 DT.121461231 DT.100841842 DT.121461248 DT.121461281 DT.121461293

DT.121461297 DT.100882584 DT.92449717 DT.121461261 DT.308052

24/619 AceView cDNA sequences (see all 619):

AV704206 F04774 BQ651034 BI962959 CR595628 F08756 CR607896 BF526579

CB113334 H66592 BM704182 AL531763 CR592799 CR625369 BI822282 BM718672

CB134887 AA300076 T67578 BX443943 BX449097 CB134246 CR591984 BQ648227

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for AGT About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6
SP1:
SP2:

ECgene alternative splicing isoforms for AGT

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AGT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTGAGCAG

About this image

AGT expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Visceral White Adipocytes

Adipose

Amacrine, Retina

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Human kidney epithelial cell spheroids (Kidney spheroids for...)

See AGT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AGT

SOURCE GeneReport for Unigene cluster: Hs.19383

UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019

Tissue specificity: Expressed by the liver and secreted in plasma

SABiosciences Expression via Pathway-Focused PCR Arrays including AGT (see all 11):

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

Fibrosis in human mouse rat

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Adipogenesis in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for AGT gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Agt^{1 , 5}	angiotensinogen (serpin peptidase inhibitor, clade more^{1, 5}	71.29(n)¹ 60.92(a)¹		8 (72.81 cM)⁵ 11606¹ NM_007428.3¹ NP_031454.3¹ 124556587⁵
chicken (Gallus gallus)	Aves	AGT¹	angiotensinogen (serpin peptidase inhibitor, clade more	52.77(n) 39.96(a)		421543 XM_419584.3 XP_419584.2
lizard (Anolis carolinensis)	Reptilia	AGT⁶	--	33(a)	1 ↔ 1	1(222829189-222834987)
zebrafish (Danio rerio)	Actinopterygii	agt¹	angiotensinogen	44.67(n) 29.66(a)		322485 NM_198063.1 NP_932329.1

ENSEMBL Gene Tree for AGT (if available)
TreeFam Gene Tree for AGT (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74315283^1,2	C	pathogenic	201326619(-)	`TCCCCG/AGTAGG`	2	/Q /R	mis¹		1	NA	4474
rs699^1,2	C,F,A,H,	other	230845794(-)	`CCTGAC/TGGGAG`	2	T M	mis¹		49	MN EA NS NA WA CSA EU	20877
rs61751090^1,2	F	--	201322726(-)	`CCCACG/AGCCGT`	1	--	ds500¹		3	NS	2200
rs61751089^1,2	F	--	201322727(-)	`GCCCAC/TGGCCG`	1	--	ds500¹		3	NS	2200
rs61751088^1,2	C,F,	--	201322797(-)	`CTCCTC/GGATGG`	1	--	ds500¹		6	NS WA NA	3000
rs61751087^1,2	C,F	--	201322833(-)	`AATTTT/CCCCCC`	1	--	ds500¹		4	NS	2762
rs61751086^1,2	C,F	--	201323002(-)	`GGGGCG/AGGAAG`	1	--	ds500¹		4	NS	2776
rs61751085^1,2	F	--	201323033(-)	`AAGCAG/ATGGTG`	1	--	ds500¹		3	NS	2240
rs61751084^1,2	F	--	201323084(-)	`GCAGTC/ACTTTG`	1	--	ds500¹		3	NS	2240
rs61751083^1,2	C,F,	--	201323204(-)	`ATTTTA/GTCTTT`	1	--	ds500¹		3	NS	2240

HapMap Linkage Disequilibrium report for AGT (230838269 - 230850336 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AGT: --
Human Gene Mutation Database (HGMD): AGT

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

AGT for disorders           About GeneDecksing

OMIM gene information: 106150
OMIM disorders: 145500  267430
UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019

Genetic variations in AGT are a cause of susceptibility to essential hypertension (EHT) [MIM:145500].

Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable

cause

Defects in AGT are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive

severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably

due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype)

20/158 diseases for AGT (see all 158): About MalaCards

renal tubular dysgenesis inflammatory bowel disease atrial fibrillation essential hypertension

hypertension high blood pressure open-angle glaucoma mitral valve prolapse

end stage renal failure posterior urethral valves vesicoureteral reflux proliferative diabetic retinopathy

focal segmental glomerulosclerosis aortic aneurysm thoracic aortic aneurysm sleep apnea

congenital diaphragmatic hernia diastolic heart failure systolic heart failure diabetic retinopathy

4 diseases from the University of Copenhagen DISEASES database for AGT:

Hypertension Kidney disease Heart disease Diabetes mellitus

10/77 Novoseek disease relationships for AGT gene (see all 77) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
essential hypertension	74.9	83	9403548 (5), 18250562 (3), 15630592 (3), 19770777 (3) (see all 51)
hypertrophy	57.3	41	11758242 (5), 18559349 (3), 8943498 (2), 10419063 (1) (see all 26)
diabetic nephropathies	54.1	17	10499884 (3), 12728975 (3), 11717948 (2), 10997697 (1) (see all 11)
renal disease	52.7	28	10699153 (3), 12728975 (2), 9452999 (1), 11399656 (1) (see all 21)
atherosclerosis	51.7	33	11033054 (3), 16908765 (2), 10532681 (2), 12743015 (2) (see all 24)
gitelman syndrome	51.3	10	11316245 (1), 19605975 (1), 12897089 (1), 15361768 (1)
cardiovascular diseases	50.4	24	11345362 (1), 16033904 (1), 16531750 (1), 16513650 (1) (see all 19)
cardiac hypertrophy	46.9	8	10342781 (2), 11120697 (1), 14717335 (1), 2386231 (1) (see all 6)
preeclampsia	46.5	27	9813426 (4), 18645251 (3), 16052407 (2), 12450315 (2) (see all 11)
renal fibrosis	45.3	4	17989112 (2), 12471481 (1), 9316214 (1)

Genatlas disease: AGT

hypertension associated with molecular variants of angiotensinogen,including pregnancy-induced hypertension

(preeclampsia),also increased risk of coronary heart disease (T174M and M235 variants),excluded at least in a

population of Australian Anglo-Celtic Caucasians

Genetic Association Database (GAD): AGT
Human Genome Epidemiology (HuGE) Navigator: AGT (629 documents)

Export disorders for AGT gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for AGT gene, integrated from 9 sources (see all 1367):
(articles sorted by number of sources associating them with AGT)

Utopia: connect your pdf to the dynamic
world of online information

Primary structure of human preangiotensinogen deduced from the cloned cDNA sequence. (PubMed id 6089875)^{1, 2, 3} Kageyama R.... Nakanishi S. (1984)
Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease: a case-control study. (PubMed id 11754397)^{1, 4, 9} Tang D.C....Rodgers G.P. (2001)
[Studies of the association between angiotensinogen gene regulation and cytokines in essential hypertension] (PubMed id 14669517)^{1, 4, 9} Wang A.L....Chen S. (2003)
Association between angiotensinogen gene M235T polymorphism and mitral valve prolapse syndrome in Taiwan Chinese. (PubMed id 12479284)^{1, 4, 9} Chou H.T....Tsai F.J. (2002)
[The AGT genotype affects the antihypertensive effects of benazepril] (PubMed id 16266458)^{1, 4, 9} Yu H.M....Liu G.Z. (2005)
Association of angiotensinogen M235T and A(-6)G gene polymorphisms with coronary heart disease with independence of essential hypertension: the PROCAGENE study. Prospective Cardiac Gene. (PubMed id 11345362)^{1, 4, 9} Rodriguez-Perez J.C....Ferrario C.M. (2001)
[Association of angiotensinogen gene M235T variant with essential hypertension] (PubMed id 15067738)^{1, 4, 9} Cai S.Y....Shi Y.P. (2004)
[Association between angiotensin system gene polymorphism and essential hypertension] (PubMed id 11484170)^{1, 4, 9} Li X....Han X. (2001)
[Pharmacogenetics of angiotensin system in non diabetic nephropathy] (PubMed id 16231503)^{1, 4, 9} Coto E....Campistol J.M. (2005)
The Glu298Asp variant of the endothelial nitric oxide synthase gene is associated with an increased risk for abruptio placentae in pre-eclampsia. (PubMed id 16059745)^{1, 4, 9} Hillermann R....Gebhardt G.S. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 183	HGNC: 333	AceView: AGT	Ensembl:ENSG00000135744	euGenes: HUgn183
ECgene: AGT	Kegg: 183	H-InvDB: AGT

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for AGT	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/AGT
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=AGT
Wikipedia	http://en.wikipedia.org/wiki/Angiotensin

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Patent Information for AGT gene:
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GeneCards and IP:
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AGT Gene

angiotensinogen (serpin peptidase inhibitor, clade A, member...

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