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Aliases for AGT Gene

Aliases for AGT Gene

  • Angiotensinogen (Serpin Peptidase Inhibitor, Clade A, Member 8) 2 3
  • SERPINA8 3 4 6
  • Serpin A8 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor 3
  • Alpha-1 Antiproteinase, Antitrypsin 3
  • Alpha-1 Antiproteinase 2
  • Pre-Angiotensinogen 3
  • Angiotensinogen 3
  • Angiotensin II 3
  • Angiotensin I 3
  • Antitrypsin 2
  • ANHU 3

External Ids for AGT Gene

Previous HGNC Symbols for AGT Gene

  • SERPINA8

Previous GeneCards Identifiers for AGT Gene

  • GC01M229315
  • GC01M226566
  • GC01M227311
  • GC01M227873
  • GC01M227145
  • GC01M228904
  • GC01M230838
  • GC01M201323

Summaries for AGT Gene

Entrez Gene Summary for AGT Gene

  • The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGT Gene

AGT (Angiotensinogen (Serpin Peptidase Inhibitor, Clade A, Member 8)) is a Protein Coding gene. Diseases associated with AGT include renal tubular dysgenesis and renal tubular dysgenesis, agt-related. Among its related pathways are Signaling by GPCR and p70S6K Signaling. GO annotations related to this gene include growth factor activity and hormone activity.

UniProtKB/Swiss-Prot for AGT Gene

  • Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis

  • Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone

  • Angiotensin-3: stimulates aldosterone release

  • Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

Gene Wiki entry for AGT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGT Gene

Genomics for AGT Gene

Regulatory Elements for AGT Gene

Genomic Location for AGT Gene

Start:
230,702,523 bp from pter
End:
230,714,590 bp from pter
Size:
12,068 bases
Orientation:
Minus strand

Genomic View for AGT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGT Gene

Proteins for AGT Gene

  • Protein details for AGT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01019-ANGT_HUMAN
    Recommended name:
    Angiotensinogen
    Protein Accession:
    P01019
    Secondary Accessions:
    • Q16358
    • Q16359
    • Q96F91

    Protein attributes for AGT Gene

    Size:
    485 amino acids
    Molecular mass:
    53154 Da
    Quaternary structure:
    • During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg.

    Three dimensional structures from OCA and Proteopedia for AGT Gene

neXtProt entry for AGT Gene

Proteomics data for AGT Gene at MOPED

Post-translational modifications for AGT Gene

  • Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.
  • In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin).
  • The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin
  • Glycosylation at Asn47, Asn170, Asn304, and Asn328
  • Modification sites at PhosphoSitePlus

Other Protein References for AGT Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for AGT Gene

Domains for AGT Gene

Gene Families for AGT Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for AGT Gene

Graphical View of Domain Structure for InterPro Entry

P01019

UniProtKB/Swiss-Prot:

ANGT_HUMAN :
  • P01019
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with AGT: view

Function for AGT Gene

Molecular function for AGT Gene

GENATLAS Biochemistry: angiotensinogen,glycoprotein precursor of angiotensin II,expressed in the liver
UniProtKB/Swiss-Prot Function: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis
UniProtKB/Swiss-Prot Function: Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone
UniProtKB/Swiss-Prot Function: Angiotensin-3: stimulates aldosterone release
UniProtKB/Swiss-Prot Function: Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

LifeMap Function Summary for AGT Gene

Gene Ontology (GO) - Molecular Function for AGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity TAS 3397061
GO:0005179 hormone activity ISS --
GO:0005515 protein binding IPI 16237761
GO:0008083 growth factor activity TAS 10406457
GO:0016176 superoxide-generating NADPH oxidase activator activity TAS 19193863
genes like me logo Genes that share ontologies with AGT: view
genes like me logo Genes that share phenotypes with AGT: view

Animal Models for AGT Gene

MGI Knock Outs for AGT:

miRNA for AGT Gene

miRTarBase miRNAs that target AGT

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AGT Gene

Localization for AGT Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGT Gene COMPARTMENTS Subcellular localization image for AGT gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS --
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23376485
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with AGT: view

Pathways for AGT Gene

genes like me logo Genes that share pathways with AGT: view

Gene Ontology (GO) - Biological Process for AGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001543 ovarian follicle rupture IEA --
GO:0001558 regulation of cell growth NAS 17159080
GO:0001568 blood vessel development IEA --
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0001819 positive regulation of cytokine production TAS 17906677
genes like me logo Genes that share ontologies with AGT: view

Compounds for AGT Gene

(3) HMDB Compounds for AGT Gene

Compound Synonyms Cas Number PubMed IDs
Atorvastatin
  • Atorvastatin acid
134523-00-5
Lisinopril
  • Acerbon
83915-83-7
Simvastatin
  • (+)-Simvastatin
79902-63-9

(128) Novoseek inferred chemical compound relationships for AGT Gene

Compound -log(P) Hits PubMed IDs
losartan 80.3 71
pd123319 78.1 18
chymostatin 67.8 4
cv 11974 60.7 4
o6-methylguanine 60.3 15

(4) PharmGKB related drug/compound annotations for AGT Gene

genes like me logo Genes that share compounds with AGT: view

Transcripts for AGT Gene

mRNA/cDNA for AGT Gene

(619) Selected AceView cDNA sequences:
(11) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AGT Gene

Angiotensinogen (serpin peptidase inhibitor, clade A, member 8):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGT Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2:

Relevant External Links for AGT Gene

GeneLoc Exon Structure for
AGT
ECgene alternative splicing isoforms for
AGT

Expression for AGT Gene

mRNA expression in normal human tissues for AGT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGT Gene

This gene is overexpressed in Liver (23.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGT Gene

SOURCE GeneReport for Unigene cluster for AGT Gene Hs.19383

mRNA Expression by UniProt/SwissProt for AGT Gene

P01019-ANGT_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma
genes like me logo Genes that share expressions with AGT: view

Orthologs for AGT Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGT 35
  • 98.63 (n)
  • 98.97 (a)
REN 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AGT 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGT 35
  • 77.03 (n)
  • 67.44 (a)
AGT 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agt 35
  • 71.15 (n)
  • 61.13 (a)
Agt 16
Agt 36
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGT 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGT 36
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agt 35
  • 72.89 (n)
  • 64.54 (a)
chicken
(Gallus gallus)
Aves AGT 35
  • 52.77 (n)
  • 39.96 (a)
AGT 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGT 36
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agt 35
  • 48.08 (n)
  • 34.39 (a)
zebrafish
(Danio rerio)
Actinopterygii agt 35
  • 44.8 (n)
  • 30.05 (a)
agt 36
  • 26 (a)
OneToOne
Species with no ortholog for AGT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGT Gene

ENSEMBL:
Gene Tree for AGT (if available)
TreeFam:
Gene Tree for AGT (if available)

Paralogs for AGT Gene

No data available for Paralogs for AGT Gene

Variants for AGT Gene

Sequence variations from dbSNP and Humsavar for AGT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs699 other, - 230,710,048(-) CCTGA(C/T)GGGAG missense, reference
rs4753 -- 230,702,983(-) GCAGC(C/G)GTTTC utr-variant-3-prime
rs4762 - 230,710,231(-) GTCCA(C/T)GGTGG reference, missense
rs4932 -- 230,705,951(-) CTGGA(A/T)GAAGA missense, reference
rs5039 -- 230,710,694(-) GTGAG(C/T)AGCTG reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for AGT Gene

Variant ID Type Subtype PubMed ID
nsv832836 CNV Loss 17160897
esv2657518 CNV Deletion 23128226

Relevant External Links for AGT Gene

HapMap Linkage Disequilibrium report
AGT
Human Gene Mutation Database (HGMD)
AGT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGT Gene

Disorders for AGT Gene

(2) OMIM Diseases for AGT Gene (106150)

UniProtKB/Swiss-Prot

ANGT_HUMAN
  • Essential hypertension (EHT) [MIM:145500]: A condition in which blood pressure is consistently higher than normal with no identifiable cause. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269 PubMed:16116425}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) University of Copenhagen DISEASES for AGT Gene

(77) Novoseek inferred disease relationships for AGT Gene

Disease -log(P) Hits PubMed IDs
essential hypertension 74.9 72
hypertrophy 57.3 33
diabetic nephropathies 54.1 16
renal disease 52.7 24
atherosclerosis 51.7 29

Genatlas disease for AGT Gene

hypertension associated with molecular variants of angiotensinogen,including pregnancy-induced hypertension (preeclampsia),also increased risk of coronary heart disease (T174M and M235 variants),excluded at least in a population of Australian Anglo-Celtic Caucasians

Relevant External Links for AGT

Genetic Association Database (GAD)
AGT
Human Genome Epidemiology (HuGE) Navigator
AGT
genes like me logo Genes that share disorders with AGT: view

Publications for AGT Gene

  1. Molecular basis of human hypertension: role of angiotensinogen. (PMID: 1394429) Jeunemaitre X. … Corvol P. (Cell 1992) 3 4 23
  2. Detection and characterization of new mutations in the human angiotensinogen gene (AGT). (PMID: 7607642) Hixson J.E. … Powers P.K. (Hum. Genet. 1995) 3 4 23
  3. Nine polymorphisms of angiotensinogen gene in the susceptibility to essential hypertension. (PMID: 11191642) Sato N. … Ogihara T. (Life Sci. 2000) 3 23 48
  4. Polymorphisms of renin-angiotensin system genes in childhood IgA nephropathy. (PMID: 11354780) Maruyama K. … Yoshikawa N. (Pediatr. Nephrol. 2001) 3 23 48
  5. Candidate gene polymorphisms in cardiovascular disease: a comparative study of frequencies between a French and an Italian population. (PMID: 11341749) Pallaud C. … Visvikis S. (Clin. Chem. Lab. Med. 2001) 3 23 48

Products for AGT Gene

Sources for AGT Gene

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