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AGT Gene

protein-coding   GIFtS: 69

GC01M228904
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SERPINA8)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
ANHU 2
FLJ92595 2
FLJ97926 2
OTTHUMP00000035878 2
SERPINA8 2, 3, 5
angiotensinogen 2
pre-angiotensinogen 2
Descriptions
Serpin A8 3
alpha-1 antiproteinase, antitrypsin 2
angiotensin I 2
angiotensin II 2
angiotensinogen (serpin peptidase inhibitor, clade A,
member 8) 2
serine (or cysteine) proteinase inhibitor 2
External Ids
HGNC: 3331
Entrez Gene: 1832
UniProtKB: P010193
Ensembl: ENSG000001357447
Search outside databases for aliases for AGT gene

Previous GC identifers: GC01M229315 GC01M226566 GC01M227311 GC01M227873 GC01M227145

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for AGT:
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in
the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting
product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the
physiologically active enzyme angiotensin II. The protein is involved in maintaining blood
pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this
gene are associated with susceptibility to essential hypertension, and can cause renal tubular
dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been
associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
[provided by RefSeq]

UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019
Function: Angiotensin-3 stimulates aldosterone release

Gene Wiki entry for AGT (Angiotensin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the AGT gene  

Entrez Gene cytogenetic band: 1q42-q43   Ensembl cytogenetic band:  1q42.2   HGNC cytogenetic band: 1q41-qter

AGT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M228904:     (about GC identifiers)

Start:
228,904,892 bp from pter
End:
228,916,564 bp from pter
Size:
11,673 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004559.13  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019 (See protein sequence)
Recommended Name: Angiotensinogen precursor  
Size: 485 amino acids; 53154 Da
Subunit: During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2
and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg
Subcellular location: Secreted
Caution: It is uncertain whether Met-1 or Met-10 is the initiator
PDB structures from and Proteopedia :
1N9U (3D)    1N9V (3D)    2JP8 (3D)    
Secondary accessions: Q16358 Q16359 Q96F91

Post-translational modifications:

  • Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The
    resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as
    angiotensin-2, but a higher affinity for the AT2 receptor1


  • REFSEQ proteins: NP_000020.1  

    ENSEMBL proteins: 
    ENSP00000355627 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for AGT  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Angiotensin III, Angiotensin II, Angiotensin I)
    Human Recombinant Proteins from Abnova (AGT)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region NAS14718574
    GO:0005615 extracellular space IEA--
    GO:0005625 soluble fraction TAS6089875
    GO:0005737 cytoplasm IDA18029348
    About this table

    Antibodies for AGT: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for AGT
    R&D Systems Antibodies for AGT (Serpin A8/Angiotensinogen)
    Antibodies from Abcam (Angiotensin III, Angiotensin II, Angiotensin I), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (AGT)
    Novus Biologicals Antibodies for AGT

    Assays for AGT: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR000227 Angiotensngn
     IPR000215 Protease_inhib_I4_serpin


       GeneDecks  AGT for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P01019

    ProtoNet protein and cluster: P01019

    2 Blocks protein families:
    IPB000215 Serpin
    IPB000227 Angiotensinogen signature


    UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019
    Similarity: Belongs to the serpin family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (AGT)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (AGT)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000029

                  Applied Biosystems Silencer® siRNAs for AGT

                  Sigma-Aldrich siRNA and siRNA Panels for AGT  
                         Sigma-Aldrich shRNA Panels and shRNA for AGT  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for AGT
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_000029
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_000029
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_000029 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_000029

    UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019
    Function: In response to lowered blood pressure, the enzyme renin cleaves angiotensin-1, from
    angiotensinogen. ACE (angiotensin converting enzyme) then removes a dipeptide to yield the
    physiologically active peptide angiotensin-2, the most potent pressor substance known, which helps
    regulate volume and mineral balance of body fluids
    Function: Angiotensin-3 stimulates aldosterone release

    Genatlas biochemistry entry for AGT:
    angiotensinogen,glycoprotein precursor of angiotensin II,expressed in the liver

    11 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Agt):

    adipose tissuebehavior/neurologicalgrowth/sizehomeostasis/metabolism
    lethality-postnatalliver/biliary systemmusclenervous systemrenal/urinary system
    reproductive system

    5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867 serine-type endopeptidase inhibitor activity TAS3397061
    GO:0005179 hormone activity ISS--
    GO:0008083 growth factor activity TAS10406457
    GO:0010698 acetyltransferase activator activity IDA18971559
    GO:0031702 type 1 angiotensin receptor binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    1 Invitrogen iPath™ Online BioAtlas - Pathway for AGT (Maps provided by GeneGo):
     gp130-cytokines signaling via JAK-STAT pathway

       GeneDecks  AGT for the pathways selected above  
    About GeneDecksing

    4 Sigma-Aldrich "Your Favorite Gene" Pathways for  AGT  (Your Favorite Gene powered by Ingenuity) 
     Acute Phase Response Signaling
     Renin-Angiotensin Signaling
     Glucocorticoid Receptor Signaling
     Hepatic Fibrosis / Hepatic Stellate Cell Activation

       GeneDecks  AGT for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for AGT):
     hsa04614 Renin-angiotensin system

       GeneDecks  AGT for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  AGT 


    5/99 Interacting proteins for AGT (ENSP000003556273 P010192) via UniProtKB, MINT, and/or STRING (see all 99 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGTR1ENSP000002734303STRING (score=.999)
    AGTR2ENSP000003609733STRING (score=.998)
    ACEENSP000002908663STRING (score=.993)
    RENENSP000002721903STRING (score=.966)
    ACE2ENSP000002525193STRING (score=.962)
    About this table

    5/54 Gene Ontology (GO) biological process terms (links to tree view) (see all 54 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001543 ovarian follicle rupture IEA--
    GO:0001558 regulation of cell growth NAS17159080
    GO:0001568 blood vessel development IEA--
    GO:0001658 ureteric bud branching IEA--
    GO:0001819 positive regulation of cytokine production TAS17906677
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Compounds for AGT available from Tocris Bioscience
    CompoundAction CAS number
    Flupirtine maleateK+ channel activator[75507-68-5]
    ZD 7155 hydrochlorideSelective non-peptide AT1 antagonist[146709-78-6]
    PD 123319 ditrifluoroacetatePotent, selective non-peptide AT2 antagonist[130663-39-7]
    Y-27632 dihydrochlorideSelective p160ROCK inhibitor[146986-50-7]
    About this table


    10/62 Novoseek chemical compound relationships for AGT gene (see all 62 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    o6-methylguanine 59.41 24 14615965 (3), 1423888 (3), 2328502 (2), 7519972 (2) (see all 8)
    aliskiren 58.50 2 11799102 (1)
    sele 57.68 2 11341749 (1), 15076187 (1)
    nadph 49.96 38 17553505 (3), 15894894 (3), 14652666 (3), 19059306 (2) (see all 20)
    wortmannin 46.34 8 15652490 (1), 17404186 (1), 15317677 (1), 12763754 (1) (see all 8)
    4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine 44.90 1 17329403 (1)
    cgp42112a 41.99 2 11692164 (1), 16286564 (1)
    sodium 40.86 41 15138635 (5), 8864421 (5), 9468457 (3), 17428839 (2) (see all 18)
    phosphatidylinositol 39.69 11 17404186 (2), 18401528 (2), 12624428 (1), 15138635 (1) (see all 8)
    tyrosine 38.47 43 9774361 (3), 17510240 (3), 9648724 (2), 9486662 (2) (see all 28)
    About this table

    1 PharmGKB drug compound relationship for AGT gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    glucocorticoidsFA  8613188
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (AGT)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (AGT)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000029

                  Sigma-Aldrich siRNA and siRNA Panels for AGT  
                         Sigma-Aldrich shRNA Panels and shRNA for AGT  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_000029  

    REFSEQ mRNAs for AGT gene: 

    NM_000029.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_000029  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_000029
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_000029
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_000029 

    Additional cDNA sequence: 

    AB209769.1 AK222798.1 AK222815.1 AK293507.1 AK303755.1 AK307978.1 AK312291.1 BC011519.1 
    BT006851.1 CR591984.1 CR592799.1 CR595628.1 CR601683.1 CR606672.1 CR607896.1 CR607898.1 
    CR615493.1 CR615499.1 CR618295.1 CR618811.1 CR618903.1 CR619790.1 CR625369.1 CR625415.1 
    K02215.1 M69110.1 

    20 DOTS entries:

    DT.95161596  DT.100882586  DT.320302  DT.100882604  DT.100882590  DT.100882596  DT.100882597  DT.100882601 
    DT.121461228  DT.95161591  DT.100882579  DT.121461231  DT.100841842  DT.121461248  DT.121461281  DT.121461293 
    DT.121461297  DT.100882584  DT.308052  DT.92449717 

    24/619 AceView cDNA sequences (see all 619 ):

    AA300076 AL531991 T17343 CR601683 CB138245 NM_000029 AL531926 CR625369 
    CR595628 CR607898 AV704206 BX367012 CB152924 AL532256 BM704182 CR619790 
    T91055 BI760360 CR615493 BX448662 BG059946 CR615499 CR607896 BX443943 

    highest scoring ESTs for AGT:

    K02215 AA324741 AU116883 AU120430 AU279890 AW950905 BC011519 BG699056 BG700285 BG700639 

    Unigene Cluster for AGT:

    Angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
    Hs.19383  [show with all ESTs]
    Unigene Representative Sequence: NM_000029


    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for AGT

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
    SP1:                                          
    SP2:                                          

    About this scheme

    ECgene alternative splicing isoforms for AGT

    1 Ensembl transcript including schematic representation:
    ENST00000366667  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    AGT expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for AGT

    1 / 2 / 3

    3 probe-sets matching AGT gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    684_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 K02215 1.00 1.00 1.00 1

    202834_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000029 0.60 1.00 0.82 1

    202834_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  AGT for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GAGTGAGCAG

    SOURCE GeneReport for Unigene cluster: Hs.19383

    Expression variation in blood from EXPOLDB for AGT

    UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019
    Tissue specificity: Expressed by the liver and secreted in plasma

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for AGT gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    AGT1   -- angiotensinogen (serpin peptidase inhibitor, clade more 77.2(n)
    67.78(a)
    403783  XM_536348.2  XP_536348.2 
    chimpanzee
    (Pan troglodytes)
    AGT1   -- angiotensinogen (serpin peptidase inhibitor, clade more 98.63(n)
    98.97(a)
    450104  NM_001009032.1  NP_001009032.1 
    rat
    (Rattus norvegicus)
    Agt1   -- angiotensinogen (serpin peptidase inhibitor, clade more 72.89(n)
    64.33(a)
    24179  NM_134432.2  NP_602308.1 
    mouse
    (Mus musculus)
    Agt1, 5 8 (68.00 cM)5
    angiotensinogen (serpin peptidase inhibitor, clade more1, 5 71.29(n)1
    60.92(a)1
    116061  NM_007428.31  NP_031454.31 
     AF0458835  AF0458845  (see all 22)
    chicken
    (Gallus gallus)
    AGT1   -- angiotensinogen (serpin peptidase inhibitor, clade more 52.85(n)
    40.13(a)
    421543  XM_419584.2  XP_419584.1 
    About this table        Species with no ortholog for AGT

    ENSEMBL Gene Tree for AGT
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for AGT gene
    SERPINA102  SERPIND12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/245 NCBI SNPs in AGT are shown (see all 245 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 140)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs50461,2
    A,C,F,H,O228917021(-) GTTTTC/TCCCAG 1 -- ng31 tfbs313Minor allele frequency- T:0.15MN EA NS EU WA NA 2576
    rs20714061,2
    A,C,F,H228917264(-) TATAAT/CGACTA 1 -- ng3110Minor allele frequency- C:0.17NS EU EA WA 926
    rs20714051,2
    A,C,F,H228917281(-) TCTCTG/ATCATG 1 -- ng3113Minor allele frequency- A:0.17NS EU EA WA NA 1076
    rs50511,2
    A,C,F,H228916495(+) TCCCCT/CGGCCG 1 -- ut51 ese3 trp313Minor allele frequency- C:0.33MN NS EA NA WA 1434
    rs50491,2
    A,C,F,O228916706(-) GCACCG/AGCTCA 1 -- ut5111Minor allele frequency- A:0.16MN NS EA NA 1066
    rs6991,2
    A,C,F,H228912417(-) CCTGAC/TGGGAG 1 M/T mis117Minor allele frequency- T:0.29MN EA NS NA EU WA 4864
    --
    rs50501,2
    A,C,F,H228916509(+) CACGAT/GGCCCT 1 -- ut51 ese315Minor allele frequency- G:0.15MN EA NA NS EU WA 1418
    rs20714041,2
    A,C,F,H228917563(-) TTGTTG/TATTGT 1 -- ng3111Minor allele frequency- T:0.17EA NS EU WA 2410
    rs115680481,2
    C,F,H228918538(-) GCCTTA/CCGTAG 1 -- ng315Minor allele frequency- C:0.00NS EU EA WA 458
    rs111225801,2
    C,F,H228917667(-) aaagtA/Gattaa 1 -- ng319Minor allele frequency- G:0.15NS EU EA WA NA 624
    About this table

    HapMap Linkage Disequilibrium images for AGT (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 106150

    UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019

  • Defects in AGT are associated with susceptibility to essential hypertension [MIM:145500].
    Hypertension also occurs in 5-7% of all pregnancies where it is a leading cause of maternal, fetal
    and neonatal morbidity and mortality. Among pregnancy-induced hypertension cases, severe
    pre-eclampsia [MIM:189800] is characterized by the development of hypertension and proteinuria
    after the 20th week of pregnancy and is the most distinctive, life-threatening form
  • Defects in AGT are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an
    autosomal recessive severe disorder of renal tubular development characterized by persistent fetal
    anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios
    (the Potter phenotype)
  • 10/77 Novoseek disease relationships for AGT gene (see all 77 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    essential hypertension 74.97 75 9403548 (5), 18250562 (3), 15630592 (3), 11345362 (2) (see all 49)
    hypertrophy 56.58 37 11758242 (5), 18559349 (3), 8943498 (2), 10419063 (1) (see all 24)
    renal disease 52.70 28 10699153 (3), 12728975 (2), 9452999 (1), 11399656 (1) (see all 21)
    atherosclerosis 51.97 32 11033054 (3), 16908765 (2), 10532681 (2), 12743015 (2) (see all 23)
    diabetic nephropathies 50.67 15 10499884 (3), 12728975 (3), 11717948 (2), 10997697 (1) (see all 10)
    cardiovascular diseases 49.89 23 11345362 (1), 16033904 (1), 16531750 (1), 16513650 (1) (see all 18)
    renal fibrosis 48.03 4 17989112 (2), 12471481 (1), 9316214 (1)
    gitelman syndrome 47.04 3 11316245 (1), 12897089 (1), 15361768 (1)
    preeclampsia 46.27 27 9813426 (4), 18645251 (3), 16052407 (2), 12450315 (2) (see all 11)
    cardiac hypertrophy 44.45 7 10342781 (2), 11120697 (1), 14717335 (1), 2386231 (1) (see all 5)
    About this table

    Genatlas disease: AGT
    hypertension associated with molecular variants of angiotensinogen,including pregnancy-induced
    hypertension (preeclampsia),also increased risk of coronary heart disease (T174M and M235
    variants),excluded at least in a population of Australian Anglo-Celtic Caucasians

    Human Gene Mutation Database: AGT
    Genetic Association Database: AGT
    Human Genome Epidemiology Navigator: AGT (494 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/1097 PubMed articles for AGT gene (see all 1097 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 183 HGNC: 333 AceView: AGT Ensembl:ENSG00000135744 euGenes: HUgn183
    ECgene: AGT H-InvDB: AGT
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    GeneReviewshttp://www.genetests.org/query?gene=AGT
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=AGT
    Wikipedia http://en.wikipedia.org/wiki/Angiotensin
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for AGT:
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      Free SNP selection tool



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     Search OriGene for AGT
     Tocris compounds for AGT




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for AGT

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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