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AGT Gene

protein-coding   GIFtS: 69
GCID: GC01M230838

Angiotensinogen (Serpin Peptidase Inhibitor, Clade A, Member...


(Previous symbol: SERPINA8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Angiotensinogen (Serpin Peptidase Inhibitor, Clade A, Member 8)1 2     Alpha-1 Antiproteinase, Antitrypsin2
SERPINA81 2 3 5     Angiotensin I2
Serpin A82 3     Angiotensin II2
Alpha-1 Antiproteinase1     angiotensinogen2
antitrypsin1     pre-angiotensinogen2
ANHU2     Serine (Or Cysteine) Proteinase Inhibitor2

External Ids:    HGNC: 3331   Entrez Gene: 1832   Ensembl: ENSG000001357447   OMIM: 1061505   UniProtKB: P010193   

Export aliases for AGT gene to outside databases

Previous GC identifers: GC01M229315 GC01M226566 GC01M227311 GC01M227873 GC01M227145 GC01M228904 GC01M201323


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AGT Gene:
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and
is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is
then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II.
The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and
preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause
renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been
associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. (provided by RefSeq,
Jul 2008)

GeneCards Summary for AGT Gene:
AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)) is a protein-coding gene. Diseases associated with AGT include essential hypertension, and renal tubular dysgenesis. GO annotations related to this gene include growth factor activity and hormone activity.

UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019
Function: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body
fluid and electrolyte homeostasis
Function: Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac
contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and
water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize
and secrete aldosterone
Function: Angiotensin-3: stimulates aldosterone release
Function: Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator
and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of
nitric oxide from platelets (By similarity)

Gene Wiki entry for AGT (Angiotensin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AGT gene promoter:
         PPAR-gamma1   Sp1   STAT3   PPAR-gamma2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): AGT promoter sequence
   Search Chromatin IP Primers for AGT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.2   Ensembl cytogenetic band:  1q42.2   HGNC cytogenetic band: 1q42.2

AGT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGT gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M230838:  view genomic region     (about GC identifiers)

Start:
230,838,269 bp from pter      End:
230,850,336 bp from pter
Size:
12,068 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019 (See protein sequence)
Recommended Name: Angiotensinogen precursor  
Size: 485 amino acids; 53154 Da
Subunit: During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a
complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg
Caution: It is uncertain whether Met-1 or Met-10 is the initiator
Selected PDB 3D structures from and Proteopedia for AGT (see all 8):
1N9U (3D)        1N9V (3D)        2JP8 (3D)        2WXW (3D)        2X0B (3D)        4AA1 (3D)    
Secondary accessions: Q16358 Q16359 Q96F91

Explore the universe of human proteins at neXtProt for AGT: NX_P01019

Explore proteomics data for AGT at MOPED

Post-translational modifications: 

  • Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide
    form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the
    AT2 receptor1
  • In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1.
    Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the
    physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to
    generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further
    processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been
    proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin)1
  • The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the
    oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin1
  • Glycosylation2 at Asn47, Asn170, Asn304, Asn328
  • Modification sites at PhosphoSitePlus

  • See AGT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000020.1  
    ENSEMBL proteins: 
     ENSP00000355627  
    Reactome Protein details: P01019

    AGT Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for AGT
    OriGene Protein Over-expression Lysate for AGT
    OriGene MassSpec for AGT
    OriGene Custom Protein Services for AGT
    GenScript Custom Purified and Recombinant Proteins Services for AGT
    Novus Biologicals AGT Proteins
    Novus Biologicals AGT Lysates
    Sino Biological Recombinant Protein for AGT
    Sino Biological Cell Lysate for AGT
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AGT

    AGT Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of AGT
    R&D Systems Antibodies for AGT (Serpin A8/Angiotensinogen)
    OriGene Antibodies for AGT
    OriGene Custom Antibody Services for AGT
    Novus Biologicals AGT Antibodies
    Abcam antibodies for AGT
    Cloud-Clone Corp. Antibodies for AGT
    ThermoFisher Antibody for AGT
    LSBio Antibodies in human, mouse, rat for AGT

    AGT Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AGT
    R&D Systems Proteome Profiler Antibody Arrays for AGT (Serpin A8/Angiotensinogen)
    GenScript Custom Assay Services for AGT
    Enzo Life Sciences assays for AGT
    Cloud-Clone Corp. ELISAs for AGT
    Cloud-Clone Corp. CLIAs for AGT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    SERPIN: Serine (or cysteine) peptidase inhibitors

    4 InterPro protein domains:
     IPR023795 Serpin_CS
     IPR000227 Angiotensinogen
     IPR000215 Serpin_fam
     IPR023796 Serpin_dom

    Graphical View of Domain Structure for InterPro Entry P01019

    ProtoNet protein and cluster: P01019

    2 Blocks protein domains:
    IPB000215 Serpin
    IPB000227 Angiotensinogen signature


    UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019
    Similarity: Belongs to the serpin family


    AGT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANGT_HUMAN, P01019
    Function: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body
    fluid and electrolyte homeostasis
    Function: Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac
    contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and
    water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize
    and secrete aldosterone
    Function: Angiotensin-3: stimulates aldosterone release
    Function: Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator
    and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of
    nitric oxide from platelets (By similarity)

         Genatlas biochemistry entry for AGT:
    angiotensinogen,glycoprotein precursor of angiotensin II,expressed in the liver

         Summary: 
    During embryonic development, AGT as signaling molecule affects the following cells:
          selected tissues (see all 4)
    Endothelium: Vascular Smooth Muscle Cells (Veins)
    Lateral Plate Mesoderm: Vascular Smooth Muscle Cells (Splanchnic Mesoderm)

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IBA--
    GO:0005179hormone activity ISS--
    GO:0005515protein binding IPI18202720
    GO:0008083growth factor activity TAS10406457
    GO:0010698acetyltransferase activator activity ----
         
    AGT for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Agt):
     adipose tissue  behavior/neurological  cardiovascular system  growth/size/body  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  muscle  nervous system 
     renal/urinary system  reproductive system 

    AGT for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for AGT: Agttm1Ii Agttm1Afu Agttm1Unc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AGT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AGT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AGT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AGT

    miRNA
    Products:
        
    miRTarBase miRNAs that target AGT:
    hsa-mir-26b-5p (MIRT028917)

    Block miRNA regulation of human, mouse, rat AGT using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate AGT:
    hsa-miR-767-3p
    SwitchGear 3'UTR luciferase reporter plasmidAGT 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AGT
    Predesigned siRNA for gene silencing in human, mouse, rat AGT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AGT

    Clone
    Products:
         
    OriGene clones in human, mouse for AGT (see all 8)
    OriGene ORF clones in mouse, rat for AGT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AGT (NM_000029)
    Sino Biological Human cDNA Clone for AGT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGT

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AGT
    Browse ESI BIO Cell Lines and PureStem Progenitors for AGT 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANGT_HUMAN, P01019: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    plasma membrane2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space ISS--
    GO:0072562blood microparticle IDA--

    AGT for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AGT About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics0.37
    ACE Inhibitor Pathway, Pharmacodynamics0.00
    Renin-angiotensin system0.37
    ACE Inhibitor Pathway0.00
    2Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    5Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for AGT
        Renin-Angiotensin Pathway
    JAK-STAT Pathway
    NFAT and Cardiac Hypertrophy

    4 GeneGo (Thomson Reuters) Pathways for AGT
        Development Angiotensin activation of ERK
    Development Angiotensin signaling via beta-Arrestin
    Cell adhesion Integrin inside-out signaling
    Development Angiotensin signaling via PYK2

    Selected BioSystems Pathways for AGT (see all 6)
        ACE Inhibitor Pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Adipogenesis
    Physiological and Pathological Hypertrophy of the Heart
    Monoamine Transport


    5 Reactome Pathways for AGT
        Peptide ligand-binding receptors
    Metabolism of Angiotensinogen to Angiotensins
    PPARA activates gene expression
    G alpha (q) signalling events
    G alpha (i) signalling events

    2 PharmGKB Pathways for AGT
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for AGT):
        Renin-angiotensin system


    AGT for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AGT (see all 11): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Fibrosis in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Diabetes in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AGT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for AGT (P010191, 2, 3 ENSP000003556274) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    Agtr1P250951, 2EBI-751728,EBI-764979 MINT-6177954 MINT-6177799 MINT-6177833 MINT-6177922 MINT-6177937 MINT-6177849 MINT-6177877 MINT-6177905 MINT-6177864 MINT-6177817
    AGTR2P500521, 3, ENSP000003609734EBI-2927577,EBI-1748067 I2D: score=2 STRING: ENSP00000360973
    AGTR1P305561, 3, ENSP000002734304EBI-6622938,EBI-6623016 I2D: score=1 STRING: ENSP00000273430
    ACE2Q9BYF13, ENSP000002525194I2D: score=1 STRING: ENSP00000252519
    DNPEPQ9ULA03, ENSP000002730754I2D: score=1 STRING: ENSP00000273075
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 102):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001543ovarian follicle rupture IEA--
    GO:0001558regulation of cell growth NAS17159080
    GO:0001568blood vessel development IEA--
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0001819positive regulation of cytokine production TAS17906677

    AGT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AGT (ANGT)

    3 HMDB Compounds for AGT    About this table
    CompoundSynonyms CAS #PubMed Ids
    AtorvastatinAtorvastatin acid (see all 4)134523-00-5--
    LisinoprilAcerbon (see all 34)83915-83-7--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    Selected Novoseek inferred chemical compound relationships for AGT gene (see all 128)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    losartan 80.3 81 8160786 (6), 8491505 (4), 11256235 (4), 15194475 (3) (see all 47)
    pd123319 78.1 22 17060512 (3), 9510088 (2), 10419063 (2), 11230289 (2) (see all 12)
    chymostatin 67.8 7 8695029 (1), 12714330 (1), 9793075 (1), 8024040 (1)
    cv 11974 60.7 5 17487826 (2), 11034947 (1), 11108152 (1)
    o6-methylguanine 60.3 25 14615965 (3), 1423888 (3), 2328502 (2), 7519972 (2) (see all 9)
    remikiren 59 5 7796503 (2), 9440700 (1)
    aliskiren 57.8 2 11799102 (1)
    ang ii 55.9 5 17504233 (3), 12194787 (1)
    kn 93 55.9 3 8903426 (2), 14645496 (1)
    sele 55.6 2 11341749 (1), 15076187 (1)

    2 PharmGKB related drug/compound annotations for AGT gene    About this table
    Drug/compound PharmGKB Annotation
    Antiinflammatory agents, non-steroidsCA  
    atenololCA  



    AGT for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AGT gene: 
    NM_000029.3  

    Unigene Cluster for AGT:

    Angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
    Hs.19383  [show with all ESTs]
    Unigene Representative Sequence: NM_000029
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000366667(uc001hty.4 uc009xff.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat AGT using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate AGT:
    hsa-miR-767-3p
    SwitchGear 3'UTR luciferase reporter plasmidAGT 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AGT
    Predesigned siRNA for gene silencing in human, mouse, rat AGT
    Clone
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    OriGene clones in human, mouse for AGT (see all 8)
    OriGene ORF clones in mouse, rat for AGT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AGT (NM_000029)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGT
    Primer
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    OriGene qPCR primer pairs and template standards for AGT
    OriGene qSTAR qPCR primer pairs in human, mouse for AGT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AGT
      QuantiTect SYBR Green Assays in human, mouse, rat AGT
      QuantiFast Probe-based Assays in human, mouse, rat AGT

    Additional mRNA sequence: 

    AB209769.1 AK222798.1 AK222815.1 AK293507.1 AK303755.1 AK307978.1 AK312291.1 BC011519.1 
    BT006851.1 K02215.1 M69110.1 

    21 DOTS entries:

    DT.95161596  DT.100882586  DT.320302  DT.100882604  DT.100882590  DT.100882596  DT.100882597  DT.100882601 
    DT.121461228  DT.95161591  DT.100882579  DT.121461231  DT.100841842  DT.121461248  DT.121461281  DT.121461293 
    DT.121461297  DT.100882584  DT.92449717  DT.121461261  DT.308052 

    Selected AceView cDNA sequences (see all 619):

    BI962959 H58506 T67578 NM_000029 BF526579 BE223055 CB141225 N58109 
    CB152924 AA865244 BF062608 F04660 AA305209 F04774 AV704206 CB106554 
    BP349827 CD607171 CB135627 BI517602 CR615499 BX422416 CB141728 AL531763 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for AGT    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
    SP1:                                          
    SP2:                                          


    ECgene alternative splicing isoforms for AGT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AGT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTGAGCAG
    AGT Expression
    About this image


    AGT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
             Cerebellum
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced embryoid bodies
     
     Eye (Sensory Organs)
             AII Amacrine Cells Inner Nuclear Layer
     
     Liver (Hepatobiliary System)
             Hepatocyte-like cells
    AGT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AGT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.19383

    UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019
    Tissue specificity: Expressed by the liver and secreted in plasma

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AGT (see all 11): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Fibrosis in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Diabetes in human mouse rat
              Adipogenesis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AGT gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agt1 , 5 angiotensinogen (serpin peptidase inhibitor, clade more1, 5 71.15(n)1
    61.13(a)1
      8 (72.81 cM)5
    116061  NM_007428.31  NP_031454.31 
     1245565875 
    chicken
    (Gallus gallus)
    Aves AGT1 angiotensinogen (serpin peptidase inhibitor, clade more 52.77(n)
    39.96(a)
      421543  XM_004935491.1  XP_004935548.1 
    lizard
    (Anolis carolinensis)
    Reptilia AGT6
    angiotensinogen (serpin peptidase inhibitor, clade...
    34(a)
    1 ↔ 1
    1(222829189-222839682)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia agt1 angiotensinogen (serpin peptidase inhibitor, clade more 48.08(n)
    34.39(a)
      100127178  XM_002931506.2  XP_002931552.2 
    zebrafish
    (Danio rerio)
    Actinopterygii agt1 angiotensinogen 44.8(n)
    30.05(a)
      322485  NM_198063.1  NP_932329.1 


    ENSEMBL Gene Tree for AGT (if available)
    TreeFam Gene Tree for AGT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AGT (see all 531)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354334
    Renal tubular dysgenesis (RTD)4--see VAR_0354332 R Q mis40--------
    rs743152831,2
    Cpathogenic1237625839(-) TCCCCG/AGTAGG 2 /Q /R mis11Minor allele frequency- A:0.00NA 4474
    rs6991,2,,4
    C,F,A,Hother1237629954(-) CCTGAC/TGGGAG 2 T M mis149Minor allele frequency- G:0.00MN EA NS NA WA CSA EU 20877
    rs557208041,2
    C,F--230838312(+) CACAAG/-GGAGA 1 -- ut314Minor allele frequency- -:0.01NS 2796
    rs560136571,2
    C--230845182(+) AAAAA-/ATCAAC 1 -- int10--------
    rs583593381,2
    C--230847563(+) CGTAT-/AAAAAAAA 1 -- int10--------
    rs115680471,2
    C,F--230852324(-) AAGAAC/GAGCAC 1 -- us2k15Minor allele frequency- G:0.00NS NA 706
    rs617510901,2
    F--237621946(-) CCCACG/AGCCGT 1 -- ds50013Minor allele frequency- A:0.00NS 2200
    rs617510891,2
    F--237621947(-) GCCCAC/TGGCCG 1 -- ds50013Minor allele frequency- T:0.00NS 2200
    rs111225741,2
    C,F,H--237621968(-) GAAGCG/AGTAGG 1 -- ds500132Minor allele frequency- A:0.10NS EA NA CSA WA 5888

    HapMap Linkage Disequilibrium report for AGT (230838269 - 230850336 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AGT:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657518CNV Deletion23128226
    nsv832836CNV Loss17160897

    Human Gene Mutation Database (HGMD): AGT
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AGT
    DNA2.0 Custom Variant and Variant Library Synthesis for AGT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 106150   
    OMIM disorders: 145500  267430  
    UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019
  • Essential hypertension (EHT) [MIM:145500]: A condition in which blood pressure is consistently higher
    than normal with no identifiable cause. Note=Disease susceptibility is associated with variations affecting the
    gene represented in this entry
  • Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular
    development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia
    from early-onset oligohydramnios (the Potter phenotype). Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • Selected diseases for AGT (see all 147):    
    About MalaCards
    essential hypertension    renal tubular dysgenesis    renal tubular dysgenesis, agt-related    pre-eclampsia
    familial hypertension    posterior urethral valves    posterior urethral valve    inflammatory bowel disease
    primary hyperoxaluria type 1    urethritis    anuria    hypertension
    primary hyperoxaluria    mitral valve disease    gitelman syndrome    renovascular hypertension
    sick sinus syndrome    sleep apnea    mitral valve prolapse    aortic coarctation

    4 diseases from the University of Copenhagen DISEASES database for AGT:
    Hypertension     Kidney disease     Heart disease     Diabetes mellitus

    AGT for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for AGT gene (see all 77)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    essential hypertension 74.9 83 9403548 (5), 18250562 (3), 15630592 (3), 19770777 (3) (see all 51)
    hypertrophy 57.3 41 11758242 (5), 18559349 (3), 8943498 (2), 10419063 (1) (see all 26)
    diabetic nephropathies 54.1 17 10499884 (3), 12728975 (3), 11717948 (2), 10997697 (1) (see all 11)
    renal disease 52.7 28 10699153 (3), 12728975 (2), 9452999 (1), 11399656 (1) (see all 21)
    atherosclerosis 51.7 33 11033054 (3), 16908765 (2), 10532681 (2), 12743015 (2) (see all 24)
    gitelman syndrome 51.3 10 11316245 (1), 19605975 (1), 12897089 (1), 15361768 (1)
    cardiovascular diseases 50.4 24 11345362 (1), 16033904 (1), 16531750 (1), 16513650 (1) (see all 19)
    cardiac hypertrophy 46.9 8 10342781 (2), 11120697 (1), 14717335 (1), 2386231 (1) (see all 6)
    preeclampsia 46.5 27 9813426 (4), 18645251 (3), 16052407 (2), 12450315 (2) (see all 11)
    renal fibrosis 45.3 4 17989112 (2), 12471481 (1), 9316214 (1)

    Genatlas disease: AGT
    hypertension associated with molecular variants of angiotensinogen,including pregnancy-induced hypertension
    (preeclampsia),also increased risk of coronary heart disease (T174M and M235 variants),excluded at least in a
    population of Australian Anglo-Celtic Caucasians

    Genetic Association Database (GAD): AGT
    Human Genome Epidemiology (HuGE) Navigator: AGT (629 documents)

    Export disorders for AGT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AGT gene, integrated from 10 sources (see all 1430):
    (articles sorted by number of sources associating them with AGT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of human preangiotensinogen deduced from the cloned cDNA sequence. (PubMed id 6089875)1, 2, 3 Kageyama R.... Nakanishi S. (Biochemistry 1984)
    2. Genotype-phenotype analysis of angiotensinogen polymorphisms and essential hypertension: the importance of haplotypes. (PubMed id 19770777)1, 4, 9 Watkins W.S....Jorde L.B. (J. Hypertens. 2010)
    3. Angiotensinogen promoter variants influence gene expression in human kidney and visceral adipose tissue. (PubMed id 19536167)1, 4, 9 Sarzani R....Rappelli A. (J Hum Hypertens 2010)
    4. No evidence for association between the renin-angiotensin-aldosterone system and otosclerosis in a large Belgian-Dutch population. (PubMed id 19503013)1, 4, 9 Schrauwen I....Van Camp G. (amp 2009)
    5. Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease: a case-control study. (PubMed id 11754397)1, 4, 9 Tang D.C....Rodgers G.P. (Am. J. Hematol. 2001)
    6. Nine polymorphisms of angiotensinogen gene in the susceptibility to essential hypertension. (PubMed id 11191642)1, 4, 9 Sato N....Ogihara T. (Life Sci. 2000)
    7. [Studies of the association between angiotensinogen gene regulation and cytokines in essential hypertension]. (PubMed id 14669517)1, 4, 9 Wang A.L....Chen S. (Yi Chuan Xue Bao 2003)
    8. An association study of angiotensinogen polymorphisms with serum level and hypertension in an African-American population. (PubMed id 14508190)1, 4, 9 Wu X....Cooper R.S. (J. Hypertens. 2003)
    9. Association between angiotensinogen gene M235T polymorphism and mitral valve prolapse syndrome in Taiwan Chinese. (PubMed id 12479284)1, 4, 9 Chou H.T....Tsai F.J. (J. Heart Valve Dis. 2002)
    10. Lack of association between renin-angiotensin system (RAS) polymorphisms and hypertension in Tunisian type 2 diabetics. (PubMed id 20415212)1, 4, 9 Arfa I....Abdelhak S. (Tunis Med 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 183 HGNC: 333 AceView: AGT Ensembl:ENSG00000135744 euGenes: HUgn183
    ECgene: AGT Kegg: 183 H-InvDB: AGT

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AGT Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=AGT[genesymbol]
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=AGT
    Wikipedia http://en.wikipedia.org/wiki/Angiotensin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AGT gene:
    Search GeneIP for patents involving AGT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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