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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AGT Gene

protein-coding   GIFtS: 68
GCID: GC01M230838

Angiotensinogen (Serpin Peptidase Inhibitor, Clade A, Member...


(Previous symbol: SERPINA8)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Angiotensinogen (Serpin Peptidase Inhibitor, Clade A, Member 8)1 2     Alpha-1 Antiproteinase, Antitrypsin2
SERPINA81 2 3 5     Angiotensin I2
Serpin A82 3     Angiotensin II2
Alpha-1 Antiproteinase1     angiotensinogen2
antitrypsin1     pre-angiotensinogen2
ANHU2     Serine (Or Cysteine) Proteinase Inhibitor2

External Ids:    HGNC: 3331   Entrez Gene: 1832   Ensembl: ENSG000001357447   OMIM: 1061505   UniProtKB: P010193   

Export aliases for AGT gene to outside databases

Previous GC identifers: GC01M229315 GC01M226566 GC01M227311 GC01M227873 GC01M227145 GC01M228904 GC01M201323


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AGT Gene:
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and
is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is
then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II.
The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and
preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause
renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been
associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. (provided by RefSeq,
Jul 2008)

GeneCards Summary for AGT Gene: 
AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)) is a protein-coding gene. Diseases associated with AGT include essential hypertension, and renal tubular dysgenesis, and among its related super-pathways are ACE Inhibitor Pathway and Metabolism of Angiotensinogen to Angiotensins. GO annotations related to this gene include growth factor activity and hormone activity.

UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019
Function: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body
fluid and electrolyte homeostasis
Function: Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac
contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and
water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize
and secrete aldosterone
Function: Angiotensin-3: stimulates aldosterone release
Function: Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator
and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of
nitric oxide from platelets (By similarity)

Gene Wiki entry for AGT (Angiotensin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AGT gene promoter:
         PPAR-gamma1   Sp1   STAT3   PPAR-gamma2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): AGT promoter sequence
   Search SABiosciences Chromatin IP Primers for AGT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.2   Ensembl cytogenetic band:  1q42.2   HGNC cytogenetic band: 1q42.2

AGT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGT gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M230838:  view genomic region     (about GC identifiers)

Start:
230,838,269 bp from pter      End:
230,850,336 bp from pter
Size:
12,068 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019 (See protein sequence)
Recommended Name: Angiotensinogen precursor  
Size: 485 amino acids; 53154 Da
Subunit: During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a
complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg
Subcellular location: Secreted
Caution: It is uncertain whether Met-1 or Met-10 is the initiator
6/8 PDB 3D structures from and Proteopedia for AGT (see all 8):
1N9U (3D)        1N9V (3D)        2JP8 (3D)        2WXW (3D)        2X0B (3D)        4AA1 (3D)    
Secondary accessions: Q16358 Q16359 Q96F91

Explore the universe of human proteins at neXtProt for AGT: NX_P01019

Explore proteomics data for AGT at MOPED 

Post-translational modifications:

  • UniProtKB: Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide
    form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the
    AT2 receptor
  • UniProtKB: In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1.
    Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the
    physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to
    generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further
    processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been
    proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin)
  • UniProtKB: The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the
    oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P01019

  • AGT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AGT Protein Expression
    REFSEQ proteins: NP_000020.1  
    ENSEMBL proteins: 
     ENSP00000355627  
    Reactome Protein details: P01019
    Human Recombinant Protein Products for AGT: 
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    OriGene MassSpec for AGT 
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    GenScript Custom Purified and Recombinant Proteins Services for AGT
    Novus Biologicals AGT Proteins
    Novus Biologicals AGT Lysates
    Sino Biological Recombinant Protein for AGT
    Sino Biological Cell Lysate for AGT 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AGT 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space ISS--
    GO:0044444cytoplasmic part ----

    AGT for ontologies           About GeneDecksing



    AGT Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of AGT
    R&D Systems Antibodies for AGT (Serpin A8/Angiotensinogen)
    OriGene Antibodies for AGT
    OriGene Custom Antibody Services for AGT
    GenScript Custom Superior Antibodies Services for AGT
    Novus Biologicals AGT Antibodies
    Abcam antibodies for AGT
    Cloud-Clone Corp. Antibodies for AGT 
    ThermoFisher Antibody for AGT
    LSBio Antibodies in human, mouse, rat for AGT 

    Assay Products for AGT: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Proteome Profiler Antibody Arrays for AGT (Serpin A8/Angiotensinogen)
    GenScript Custom Assay Services for AGT
    Enzo Life Sciences assays for AGT
    Cloud-Clone Corp. ELISAs for AGT 
    Cloud-Clone Corp. CLIAs for AGT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    SERPIN: Serine (or cysteine) peptidase inhibitors

    4 InterPro protein domains:
     IPR023795 Protease_inhib_I4_serpin_CS
     IPR023796 Serpin_dom
     IPR000227 Angiotensngn
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry P01019

    ProtoNet protein and cluster: P01019

    2 Blocks protein domains:
    IPB000215 Serpin
    IPB000227 Angiotensinogen signature


    UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019
    Similarity: Belongs to the serpin family


    AGT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANGT_HUMAN, P01019
    Function: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body
    fluid and electrolyte homeostasis
    Function: Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac
    contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and
    water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize
    and secrete aldosterone
    Function: Angiotensin-3: stimulates aldosterone release
    Function: Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator
    and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of
    nitric oxide from platelets (By similarity)

         Genatlas biochemistry entry for AGT:
    angiotensinogen,glycoprotein precursor of angiotensin II,expressed in the liver

         Summary:
    During embryonic development, AGT as signaling molecule
    affects the following cells: Ureteric Bud Tip Cells in Ureteric Bud, Vascular Smooth Muscle Cells in Veins (see all 4).

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IBA--
    GO:0005179hormone activity ISS--
    GO:0005515protein binding IPI18202720
    GO:0008083growth factor activity TAS10406457
    GO:0010698acetyltransferase activator activity IDA18971559
         
    AGT for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Agt):
     adipose tissue  behavior/neurological  cardiovascular system  growth/size  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  muscle  nervous system 
     renal/urinary system  reproductive system 

    AGT for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for AGT: Agttm1Ii Agttm1Afu Agttm1Unc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AGT 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AGT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AGT 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AGT 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AGT
    1 QIAGEN miScript miRNA Assays for microRNA that regulate AGT:
    hsa-miR-767-3p
    SwitchGear 3'UTR luciferase reporter plasmidAGT 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AGT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AGT
    Sirion Biotech Customized adenovirus for overexpression of AGT

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for AGT (see all 8)
    OriGene ORF clones in mouse, rat for AGT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AGT (NM_000029)
    Sino Biological Human cDNA Clone for AGT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGT
    Sirion Biotech Customized lentivirus for stable overexpression of AGT 
                         Customized lentivirus expression plasmids for stable overexpression of AGT 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for AGT
    Search LifeMap BioReagents cell lines for AGT
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGT


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AGT About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    ACE Inhibitor Pathway0.85
    ACE Inhibitor Pathway, Pharmacodynamics0.85
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics0.85
    2Renin-angiotensin system
    Renin-angiotensin system0.43
    Metabolism of Angiotensinogen to Angiotensins0.43
    3Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    5Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.74
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    PPARA Activates Gene Expression0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AGT
        Renin-Angiotensin Pathway
    JAK-STAT Pathway
    NFAT and Cardiac Hypertrophy

    4 GeneGo (Thomson Reuters) Pathways for AGT
        Development Angiotensin activation of ERK
    Development Angiotensin signaling via beta-Arrestin
    Cell adhesion Integrin inside-out signaling
    Development Angiotensin signaling via PYK2

    5 BioSystems Pathways for AGT
        ACE Inhibitor Pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Adipogenesis
    Monoamine Transport
    Signaling events mediated by PRL


    5/17        Reactome Pathways for AGT (see all 17)
        Peptide ligand-binding receptors
    GPCR downstream signaling
    Gastrin-CREB signalling pathway via PKC and MAPK
    Metabolism
    Signaling by GPCR

    2 PharmGKB Pathways for AGT
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

    1         Kegg Pathway  (Kegg details for AGT):
        Renin-angiotensin system


    AGT for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AGT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/27 Interacting proteins for AGT (P010192, 3 ENSP000003556274) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGTR2P500523, ENSP000003609734I2D: score=2 STRING: ENSP00000360973
    ACE2Q9BYF13, ENSP000002525194I2D: score=1 STRING: ENSP00000252519
    AGTR1P305563, ENSP000002734304I2D: score=1 STRING: ENSP00000273430
    DNPEPQ9ULA03, ENSP000002730754I2D: score=1 STRING: ENSP00000273075
    ENPEPQ070753, ENSP000002651624I2D: score=1 STRING: ENSP00000265162
    About this table

    Gene Ontology (GO): 5/99 biological process terms (GO ID links to tree view) (see all 99):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001543ovarian follicle rupture IEA--
    GO:0001558regulation of cell growth NAS17159080
    GO:0001568blood vessel development IEA--
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0001819positive regulation of cytokine production TAS17906677

    AGT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AGT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AGT (ANGT)

    3 HMDB Compounds for AGT    About this table
    CompoundSynonyms CAS #PubMed Ids
    AtorvastatinAtorvastatin acid (see all 4)134523-00-5--
    LisinoprilAcerbon (see all 34)83915-83-7--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    10/128 Novoseek inferred chemical compound relationships for AGT gene (see all 128)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    losartan 80.3 81 8160786 (6), 8491505 (4), 11256235 (4), 15194475 (3) (see all 47)
    pd123319 78.1 22 17060512 (3), 9510088 (2), 10419063 (2), 11230289 (2) (see all 12)
    chymostatin 67.8 7 8695029 (1), 12714330 (1), 9793075 (1), 8024040 (1)
    cv 11974 60.7 5 17487826 (2), 11034947 (1), 11108152 (1)
    o6-methylguanine 60.3 25 14615965 (3), 1423888 (3), 2328502 (2), 7519972 (2) (see all 9)
    remikiren 59 5 7796503 (2), 9440700 (1)
    aliskiren 57.8 2 11799102 (1)
    ang ii 55.9 5 17504233 (3), 12194787 (1)
    kn 93 55.9 3 8903426 (2), 14645496 (1)
    sele 55.6 2 11341749 (1), 15076187 (1)

    2 PharmGKB related drug/compound annotations for AGT gene    About this table
    Drug/compound PharmGKB Annotation
    Antiinflammatory agents, non-steroidsCA  
    atenololCA  

    Search CenterWatch for drugs/clinical trials and news about AGT / ANGT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AGT gene: 
    NM_000029.3  

    Unigene Cluster for AGT:

    Angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
    Hs.19383  [show with all ESTs]
    Unigene Representative Sequence: NM_000029
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000366667(uc001hty.4 uc009xff.3)

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate AGT:
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    SwitchGear 3'UTR luciferase reporter plasmidAGT 3' UTR sequence
    Inhib. RNA
    Products:
         
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    GenScript: all cDNA clones in your preferred vector: AGT (NM_000029)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGT
    Sirion Biotech Customized lentivirus for stable overexpression of AGT 
                         Customized lentivirus expression plasmids for stable overexpression of AGT 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGT

    Additional mRNA sequence: 

    AB209769.1 AK222798.1 AK222815.1 AK293507.1 AK303755.1 AK307978.1 AK312291.1 BC011519.1 
    BT006851.1 K02215.1 M69110.1 

    21 DOTS entries:

    DT.95161596  DT.100882586  DT.320302  DT.100882604  DT.100882590  DT.100882596  DT.100882597  DT.100882601 
    DT.121461228  DT.95161591  DT.100882579  DT.121461231  DT.100841842  DT.121461248  DT.121461281  DT.121461293 
    DT.121461297  DT.100882584  DT.92449717  DT.121461261  DT.308052 

    24/619 AceView cDNA sequences (see all 619):

    CD678405 CR615499 H58506 CB152924 AL531646 CR606672 CR619790 BX449097 
    NM_000029 BX367012 F04660 CR618295 AA300076 CB141728 T16325 BQ651034 
    T91055 CR618811 CR591984 CB134246 BM704182 CR618903 F01793 CB144235 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for AGT    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
    SP1:                                          
    SP2:                                          


    ECgene alternative splicing isoforms for AGT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AGT expression in normal human tissues (normalized intensities)      AGT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTGAGCAG
    AGT Expression
    About this image


    AGT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Endothelial Cells Blood Brain Barrier
             Thalamus
             Olfactory Bulb   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
             Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Ventral Horn   
     
     Liver (Hepatobiliary System)
             Human Hepatocyte (HH)   
     
     Peripheral Nervous System (Nervous System)
             Dorsal root ganglia   

    See AGT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AGT

    SOURCE GeneReport for Unigene cluster: Hs.19383

    UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019
    Tissue specificity: Expressed by the liver and secreted in plasma

        SABiosciences Expression via Pathway-Focused PCR Arrays including AGT (see all 11): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Fibrosis in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Diabetes in human mouse rat
              Adipogenesis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for AGT gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agt1 , 5 angiotensinogen (serpin peptidase inhibitor, clade more1, 5 71.29(n)1
    60.92(a)1
      8 (72.81 cM)5
    116061  NM_007428.31  NP_031454.31 
     1245565875 
    chicken
    (Gallus gallus)
    Aves AGT1 angiotensinogen (serpin peptidase inhibitor, clade more 52.77(n)
    39.96(a)
      421543  XM_419584.3  XP_419584.2 
    lizard
    (Anolis carolinensis)
    Reptilia AGT6
    Uncharacterized protein
    34(a)
    1 ↔ 1
    1(222829189-222839682)
    zebrafish
    (Danio rerio)
    Actinopterygii agt1 angiotensinogen 44.67(n)
    29.66(a)
      322485  NM_198063.1  NP_932329.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spn43Ad6
    Spn31A6
    (see all 4)
    Serpin 31A
    (see all 4)
    17(a)
    17(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    2R(3041242-3042927)
    2L(10060871-10063925)


    ENSEMBL Gene Tree for AGT (if available)
    TreeFam Gene Tree for AGT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/531 SNPs in AGT are shown (see all 531)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354334
    Renal tubular dysgenesis (RTD)4--see VAR_0354332 R Q mis40--------
    rs743152831,2
    Cpathogenic1237625839(-) TCCCCG/AGTAGG 2 /Q /R mis11Minor allele frequency- A:0.00NA 4474
    rs6991,2,4
    C,F,A,Hother1237629954(-) CCTGAC/TGGGAG 2 T M mis149Minor allele frequency- G:0.00MN EA NS NA WA CSA EU 20877
    VAR_0070944
    ----see VAR_0070942 T I mis40--------
    rs557208041,2
    C,F--230838312(+) CACAAG/-GGAGA 1 -- ut314Minor allele frequency- -:0.01NS 2796
    rs560136571,2
    C--230845182(+) AAAAA-/ATCAAC 1 -- int10--------
    rs583593381,2
    C--230847563(+) CGTAT-/AAAAAAAA 1 -- int10--------
    rs115680471,2
    C,F--230852324(-) AAGAAC/GAGCAC 1 -- us2k15Minor allele frequency- G:0.00NS NA 706
    rs617510901,2
    F--237621946(-) CCCACG/AGCCGT 1 -- ds50013Minor allele frequency- A:0.00NS 2200
    rs617510891,2
    F--237621947(-) GCCCAC/TGGCCG 1 -- ds50013Minor allele frequency- T:0.00NS 2200

    HapMap Linkage Disequilibrium report for AGT (230838269 - 230850336 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AGT:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2657518CNV Deletion23128226
    nsv832836CNV Loss17160897


    Human Gene Mutation Database (HGMD): AGT
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for AGT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 106150   
    OMIM disorders: 145500  267430  
    UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019
  • Essential hypertension (EHT) [MIM:145500]: A condition in which blood pressure is consistently higher
    than normal with no identifiable cause. Note=Disease susceptibility is associated with variations affecting the
    gene represented in this entry
  • Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular
    development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia
    from early-onset oligohydramnios (the Potter phenotype). Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 20/147 diseases for AGT (see all 147):    About MalaCards
    essential hypertension    renal tubular dysgenesis    renal tubular dysgenesis, agt-related    familial hypertension
    posterior urethral valves    posterior urethral valve    primary hyperoxaluria type 1    hypertension
    fluid and electrolyte balance    primary hyperoxaluria    anuria    gitelman syndrome
    renovascular hypertension    mitral valve disease    sleep apnea    diastolic heart failure
    aortic coarctation    mitral valve prolapse    fibromuscular dysplasia    malignant hypertension

    4 diseases from the University of Copenhagen DISEASES database for AGT:
    Hypertension     Kidney disease     Heart disease     Diabetes mellitus

    AGT for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/77 Novoseek inferred disease relationships for AGT gene (see all 77)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    essential hypertension 74.9 83 9403548 (5), 18250562 (3), 15630592 (3), 19770777 (3) (see all 51)
    hypertrophy 57.3 41 11758242 (5), 18559349 (3), 8943498 (2), 10419063 (1) (see all 26)
    diabetic nephropathies 54.1 17 10499884 (3), 12728975 (3), 11717948 (2), 10997697 (1) (see all 11)
    renal disease 52.7 28 10699153 (3), 12728975 (2), 9452999 (1), 11399656 (1) (see all 21)
    atherosclerosis 51.7 33 11033054 (3), 16908765 (2), 10532681 (2), 12743015 (2) (see all 24)
    gitelman syndrome 51.3 10 11316245 (1), 19605975 (1), 12897089 (1), 15361768 (1)
    cardiovascular diseases 50.4 24 11345362 (1), 16033904 (1), 16531750 (1), 16513650 (1) (see all 19)
    cardiac hypertrophy 46.9 8 10342781 (2), 11120697 (1), 14717335 (1), 2386231 (1) (see all 6)
    preeclampsia 46.5 27 9813426 (4), 18645251 (3), 16052407 (2), 12450315 (2) (see all 11)
    renal fibrosis 45.3 4 17989112 (2), 12471481 (1), 9316214 (1)

    Genatlas disease: AGT
    hypertension associated with molecular variants of angiotensinogen,including pregnancy-induced hypertension
    (preeclampsia),also increased risk of coronary heart disease (T174M and M235 variants),excluded at least in a
    population of Australian Anglo-Celtic Caucasians

    Genetic Association Database (GAD): AGT
    Human Genome Epidemiology (HuGE) Navigator: AGT (629 documents)

    Export disorders for AGT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AGT gene, integrated from 9 sources (see all 1407):
    (articles sorted by number of sources associating them with AGT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of human preangiotensinogen deduced from the cloned cDNA sequence. (PubMed id 6089875)1, 2, 3 Kageyama R.... Nakanishi S. (1984)
    2. Genotype-phenotype analysis of angiotensinogen polymo rphisms and essential hypertension: the importance of haplotypes. (PubMed id 19770777)1, 4, 9 Watkins W.S....Jorde L.B. (2010)
    3. Angiotensinogen promoter variants influence gene expression in human kidney and visceral adipose tissue. (PubMed id 19536167)1, 4, 9 Sarzani R....Rappelli A. (2010)
    4. No evidence for association between the renin-angiote nsin-aldosterone system and otosclerosis in a large Belgian-Dutch population. (PubMed id 19503013)1, 4, 9 Schrauwen I....Van Camp G. (2009)
    5. Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease: a case-control study. (PubMed id 11754397)1, 4, 9 Tang D.C....Rodgers G.P. (2001)
    6. Nine polymorphisms of angiotensinogen gene in the susceptibility to essential hypertension. (PubMed id 11191642)1, 4, 9 Sato N....Ogihara T. (2000)
    7. [Studies of the association between angiotensinogen gene regulation and cytokines in essential hypertension] (PubMed id 14669517)1, 4, 9 Wang A.L....Chen S. (2003)
    8. An association study of angiotensinogen polymorphisms with serum level and hypertension in an African-American population. (PubMed id 14508190)1, 4, 9 Wu X....Cooper R.S. (2003)
    9. Association between angiotensinogen gene M235T polymorphism and mitral valve prolapse syndrome in Taiwan Chinese. (PubMed id 12479284)1, 4, 9 Chou H.T....Tsai F.J. (2002)
    10. Lack of association between renin-angiotensin system (RAS) polymorphisms and hypertension in Tunisian type 2 diabetics. (PubMed id 20415212)1, 4, 9 Arfa I....Abdelhak S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 183 HGNC: 333 AceView: AGT Ensembl:ENSG00000135744 euGenes: HUgn183
    ECgene: AGT Kegg: 183 H-InvDB: AGT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AGT Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/AGT
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=AGT
    Wikipedia http://en.wikipedia.org/wiki/Angiotensin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AGT gene:
    Search GeneIP for patents involving AGT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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