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Aliases for AGT Gene

Aliases for AGT Gene

  • Angiotensinogen 2 3 3 5
  • Serpin Peptidase Inhibitor, Clade A, Member 8 2 3
  • Alpha-1 Antiproteinase, Antitrypsin 2 3
  • Serpin A8 3 4
  • SERPINA8 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor 3
  • Pre-Angiotensinogen 3
  • Angiotensin II 3
  • Angiotensin I 3
  • ANHU 3

External Ids for AGT Gene

Previous HGNC Symbols for AGT Gene

  • SERPINA8

Previous GeneCards Identifiers for AGT Gene

  • GC01M229315
  • GC01M226566
  • GC01M227311
  • GC01M227873
  • GC01M227145
  • GC01M228904
  • GC01M230838
  • GC01M201323

Summaries for AGT Gene

Entrez Gene Summary for AGT Gene

  • The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGT Gene

AGT (Angiotensinogen) is a Protein Coding gene. Diseases associated with AGT include Renal Tubular Dysgenesis and Hypertension, Essential. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include growth factor activity and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINH1.

UniProtKB/Swiss-Prot for AGT Gene

  • Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.

  • Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.

  • Angiotensin-3: stimulates aldosterone release.

  • Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

Gene Wiki entry for AGT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGT Gene

Genomics for AGT Gene

Regulatory Elements for AGT Gene

Enhancers for AGT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F230712 1.3 Ensembl ENCODE 57.3 +0.8 759 3.4 ATF1 MLX ZFP64 ARID4B FEZF1 DMAP1 ZNF48 YY1 SLC30A9 FOS AGT GC01P230666
GH01F230750 1.7 VISTA Ensembl ENCODE 16.3 -38.2 -38247 5.2 ELF3 PKNOX1 ZNF76 KLF17 ARID4B SIN3A ZSCAN9 RAD21 RARA GLIS2 CAPN9 AGT COG2 GC01P230769
GH01F230707 1 ENCODE 18 +5.5 5541 2.2 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 ZNF121 SP5 NFYC ZHX2 AGT GC01P230666
GH01F230728 1.3 Ensembl ENCODE 7.3 -14.7 -14688 1.6 MLX ARID4B DMAP1 ZNF48 YY1 SP5 ZHX2 MXD4 PPARG KAT8 COG2 AGT GC01P230729
GH01F230758 0.8 ENCODE 11.4 -45.0 -45017 2.5 CTCF ESRRA SAP130 TAL1 ARID4B EBF1 ZNF48 RAD21 TEAD3 ZKSCAN1 CAPN9 AGT COG2 LOC101927604 GC01P230769
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AGT on UCSC Golden Path with GeneCards custom track

Genomic Location for AGT Gene

Chromosome:
1
Start:
230,702,523 bp from pter
End:
230,714,590 bp from pter
Size:
12,068 bases
Orientation:
Minus strand

Genomic View for AGT Gene

Genes around AGT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGT Gene

Proteins for AGT Gene

  • Protein details for AGT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01019-ANGT_HUMAN
    Recommended name:
    Angiotensinogen
    Protein Accession:
    P01019
    Secondary Accessions:
    • Q16358
    • Q16359
    • Q96F91

    Protein attributes for AGT Gene

    Size:
    485 amino acids
    Molecular mass:
    53154 Da
    Quaternary structure:
    • During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg.

    Three dimensional structures from OCA and Proteopedia for AGT Gene

neXtProt entry for AGT Gene

Post-translational modifications for AGT Gene

  • Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.
  • In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin).
  • The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.
  • Glycosylation at Asn 47, Asn 170, Asn 304, and Asn 328
  • Modification sites at PhosphoSitePlus

Other Protein References for AGT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AGT Gene

Domains & Families for AGT Gene

Graphical View of Domain Structure for InterPro Entry

P01019

UniProtKB/Swiss-Prot:

ANGT_HUMAN :
  • Belongs to the serpin family.
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with AGT: view

Function for AGT Gene

Molecular function for AGT Gene

GENATLAS Biochemistry:
angiotensinogen,glycoprotein precursor of angiotensin II,expressed in the liver
UniProtKB/Swiss-Prot Function:
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
UniProtKB/Swiss-Prot Function:
Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
UniProtKB/Swiss-Prot Function:
Angiotensin-3: stimulates aldosterone release.
UniProtKB/Swiss-Prot Function:
Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

Gene Ontology (GO) - Molecular Function for AGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity TAS 3397061
GO:0005179 hormone activity IEA,ISS --
GO:0005515 protein binding IPI 16237761
GO:0008083 growth factor activity TAS 10406457
GO:0031701 angiotensin receptor binding IEA --
genes like me logo Genes that share ontologies with AGT: view
genes like me logo Genes that share phenotypes with AGT: view

Human Phenotype Ontology for AGT Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for AGT Gene

MGI Knock Outs for AGT:

Animal Model Products

miRNA for AGT Gene

miRTarBase miRNAs that target AGT

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for AGT Gene

Localization for AGT Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGT gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
lysosome 2

Gene Ontology (GO) - Cellular Components for AGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS,TAS --
GO:0005615 extracellular space IEA,ISS --
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23376485
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with AGT: view

Pathways & Interactions for AGT Gene

genes like me logo Genes that share pathways with AGT: view

SIGNOR curated interactions for AGT Gene

Activates:

Gene Ontology (GO) - Biological Process for AGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 17159080
GO:0001819 positive regulation of cytokine production TAS 17906677
GO:0001822 kidney development IMP 16116425
GO:0001974 blood vessel remodeling TAS 10406457
GO:0002003 angiotensin maturation TAS --
genes like me logo Genes that share ontologies with AGT: view

Drugs & Compounds for AGT Gene

(89) Drugs for AGT Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lisinopril Approved, Investigational Pharma ACE inhibitor 118
Amlodipine Approved Pharma Calcium channel blocker 486
Atenolol Approved Pharma Antagonist 99
Benazepril Approved, Investigational Pharma 45
Irbesartan Approved, Investigational Pharma Antagonist Angiotensin II inhibitor 101

(54) Additional Compounds for AGT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for AGT Gene

Compound Action Cas Number
Acetyl Angiotensinogen (1-14), porcine Angiotensinogen precursor 66641-26-7
Angiotensin 1/2 (1-9) Vasoconstrictor 34273-12-6
genes like me logo Genes that share compounds with AGT: view

Transcripts for AGT Gene

mRNA/cDNA for AGT Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(619) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AGT Gene

Angiotensinogen (serpin peptidase inhibitor, clade A, member 8):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGT Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2:

Relevant External Links for AGT Gene

GeneLoc Exon Structure for
AGT
ECgene alternative splicing isoforms for
AGT

Expression for AGT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AGT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGT Gene

This gene is overexpressed in Liver (x23.4).

Protein differential expression in normal tissues from HIPED for AGT Gene

This gene is overexpressed in Serum (18.0), Synovial fluid (9.7), Plasma (7.8), Cerebrospinal fluid (7.0), and Monocytes (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AGT Gene



Protein tissue co-expression partners for AGT Gene

NURSA nuclear receptor signaling pathways regulating expression of AGT Gene:

AGT

SOURCE GeneReport for Unigene cluster for AGT Gene:

Hs.19383

mRNA Expression by UniProt/SwissProt for AGT Gene:

P01019-ANGT_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.
genes like me logo Genes that share expression patterns with AGT: view

Orthologs for AGT Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGT 34
  • 98.63 (n)
REN 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGT 34 35
  • 77.03 (n)
rat
(Rattus norvegicus)
Mammalia Agt 34
  • 72.89 (n)
mouse
(Mus musculus)
Mammalia Agt 34 16 35
  • 71.15 (n)
cow
(Bos Taurus)
Mammalia AGT 35
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGT 35
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGT 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGT 34 35
  • 52.77 (n)
lizard
(Anolis carolinensis)
Reptilia AGT 35
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agt 34
  • 48.08 (n)
zebrafish
(Danio rerio)
Actinopterygii agt 34 35
  • 44.8 (n)
Species where no ortholog for AGT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGT Gene

ENSEMBL:
Gene Tree for AGT (if available)
TreeFam:
Gene Tree for AGT (if available)

Paralogs for AGT Gene

Paralogs for AGT Gene

genes like me logo Genes that share paralogs with AGT: view

Variants for AGT Gene

Sequence variations from dbSNP and Humsavar for AGT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs74315283 Renal tubular dysgenesis (RTD) [MIM:267430], Pathogenic 230,705,933(-) TCCCC(A/G)GTAGG reference, missense
rs121912702 Pathogenic 230,710,247(-) AGGCC(C/T)AGCTG reference, stop-gained
rs387906578 Pathogenic 230,703,309(-) TTTTT(-/T)GAGCT reference, frameshift-variant
rs7080 Benign 230,705,941(-) AAACT(A/G)TCTCC reference, synonymous-codon
rs699 other 230,710,048(-) CCTGA(C/T)GGGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for AGT Gene

Variant ID Type Subtype PubMed ID
esv2657518 CNV deletion 23128226
esv3578466 CNV loss 25503493
esv3589093 CNV gain 21293372
esv3589098 CNV loss 21293372
nsv832836 CNV loss 17160897

Variation tolerance for AGT Gene

Residual Variation Intolerance Score: 90.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGT Gene

Human Gene Mutation Database (HGMD)
AGT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGT Gene

Disorders for AGT Gene

MalaCards: The human disease database

(42) MalaCards diseases for AGT Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
renal tubular dysgenesis
  • primitive renal tubule syndrome
hypertension, essential
  • hypertension, essential 3
renal tubular dysgenesis, agt-related
  • agt-related primitive renal tubule syndrome
cardiovascular disease risk factor )
  • coronary artery disease risk factor )
microvascular complications of diabetes 3
  • diabetic nephropathy
- elite association - COSMIC cancer census association via MalaCards
Search AGT in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ANGT_HUMAN
  • Essential hypertension (EHT) [MIM:145500]: A condition in which blood pressure is consistently higher than normal with no identifiable cause. {ECO:0000269 PubMed:1394429, ECO:0000269 PubMed:8513325}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269 PubMed:16116425}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for AGT Gene

hypertension associated with molecular variants of angiotensinogen,including pregnancy-induced hypertension (preeclampsia),also increased risk of coronary heart disease (T174M and M235 variants),excluded at least in a population of Australian Anglo-Celtic Caucasians

Relevant External Links for AGT

Genetic Association Database (GAD)
AGT
Human Genome Epidemiology (HuGE) Navigator
AGT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGT
genes like me logo Genes that share disorders with AGT: view

Publications for AGT Gene

  1. Genotype-phenotype analysis of angiotensinogen polymorphisms and essential hypertension: the importance of haplotypes. (PMID: 19770777) Watkins W.S. … Jorde L.B. (J. Hypertens. 2010) 3 22 46 64
  2. Angiotensinogen promoter variants influence gene expression in human kidney and visceral adipose tissue. (PMID: 19536167) Sarzani R. … Rappelli A. (J Hum Hypertens 2010) 3 22 46 64
  3. 4G/5G variant of plasminogen activator inhibitor-1 gene and severe pregnancy-induced hypertension: subgroup analyses of variants of angiotensinogen and endothelial nitric oxide synthase. (PMID: 19838007) Kobashi G. … Fujimoto S. (J Epidemiol 2009) 3 22 46 64
  4. Renin-angiotensin system and alpha-adducin gene polymorphisms and their relation to responses to antihypertensive drugs: results from the GENRES study. (PMID: 19057513) SuonsyrjAo T. … Hiltunen T.P. (Am. J. Hypertens. 2009) 3 22 46 64
  5. Angiotensinogen gene G-6A polymorphism influences idiopathic pulmonary fibrosis disease progression. (PMID: 18508830) Molina-Molina M. … Uhal B.D. (Eur. Respir. J. 2008) 3 22 46 64

Products for AGT Gene

Sources for AGT Gene

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