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AGT Gene

protein-coding GIFtS: 69

GC01M228904

angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SERPINA8)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ANHU ^²
FLJ92595 ^²
FLJ97926 ^²
OTTHUMP00000035878 ^²
SERPINA8 ^², ³, ⁵
angiotensinogen ^²
pre-angiotensinogen ^²

Descriptions
Serpin A8 ^³
alpha-1 antiproteinase, antitrypsin ^²
angiotensin I ^²
angiotensin II ^²
angiotensinogen (serpin peptidase inhibitor, clade A, member 8) ^²
serine (or cysteine) proteinase inhibitor ^²

External Ids
HGNC: 333¹
Entrez Gene: 183²
UniProtKB: P01019³
Ensembl: ENSG00000135744⁷

Search outside databases for aliases for AGT gene

Previous GC identifers: GC01M229315 GC01M226566 GC01M227311 GC01M227873 GC01M227145

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AGT:

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in

the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting

product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the

physiologically active enzyme angiotensin II. The protein is involved in maintaining blood

pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this

gene are associated with susceptibility to essential hypertension, and can cause renal tubular

dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been

associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

[provided by RefSeq]

UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019

Function: Angiotensin-3 stimulates aldosterone release

Gene Wiki entry for AGT (Angiotensin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AGT gene

Entrez Gene cytogenetic band: 1q42-q43 Ensembl cytogenetic band: 1q42.2 HGNC cytogenetic band: 1q41-qter

AGT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M228904: (about GC identifiers)

Start:	228,904,892 bp from pter
End:	228,916,564 bp from pter
Size:	11,673 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004559.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019 (See protein sequence)

Recommended Name: Angiotensinogen precursor

Size: 485 amino acids; 53154 Da

Subunit: During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2

and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg

Subcellular location: Secreted

Caution: It is uncertain whether Met-1 or Met-10 is the initiator

PDB structures from and Proteopedia :

1N9U (3D)

1N9V (3D)

2JP8 (3D)

Secondary accessions: Q16358 Q16359 Q96F91

Post-translational modifications:

Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The

resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as

angiotensin-2, but a higher affinity for the AT2 receptor¹

REFSEQ proteins: NP_000020.1

ENSEMBL proteins:

ENSP00000355627

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for AGT
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Angiotensin III, Angiotensin II, Angiotensin I)
	Human Recombinant Proteins from Abnova (AGT)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005615	extracellular space	IEA	--
GO:0005625	soluble fraction	TAS	6089875
GO:0005737	cytoplasm	IDA	18029348

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Antibodies for AGT:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for AGT
	R&D Systems Antibodies for AGT (Serpin A8/Angiotensinogen)
	Antibodies from Abcam (Angiotensin III, Angiotensin II, Angiotensin I), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AGT)
	Novus Biologicals Antibodies for AGT

Assays for AGT:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P01019

ProtoNet protein and cluster: P01019

2 Blocks protein families:

IPB000215 Serpin

IPB000227 Angiotensinogen signature

UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019

Similarity: Belongs to the serpin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AGT)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AGT)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000029

Applied Biosystems Silencer® siRNAs for AGT

Sigma-Aldrich siRNA and siRNA Panels for AGT

Sigma-Aldrich shRNA Panels and shRNA for AGT

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AGT
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000029
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000029
untagged cDNA clones in CMV expression vector (see all 2): NM_000029

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000029

UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019

Function: In response to lowered blood pressure, the enzyme renin cleaves angiotensin-1, from

angiotensinogen. ACE (angiotensin converting enzyme) then removes a dipeptide to yield the

physiologically active peptide angiotensin-2, the most potent pressor substance known, which helps

regulate volume and mineral balance of body fluids

Function: Angiotensin-3 stimulates aldosterone release

Genatlas biochemistry entry for AGT:

angiotensinogen,glycoprotein precursor of angiotensin II,expressed in the liver

11 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Agt):

	adipose tissue	behavior/neurological	growth/size	homeostasis/metabolism
lethality-postnatal	liver/biliary system	muscle	nervous system	renal/urinary system
reproductive system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004867	serine-type endopeptidase inhibitor activity	TAS	3397061
GO:0005179	hormone activity	ISS	--
GO:0008083	growth factor activity	TAS	10406457
GO:0010698	acetyltransferase activator activity	IDA	18971559
GO:0031702	type 1 angiotensin receptor binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for AGT (Your Favorite Gene powered by Ingenuity)

Acute Phase Response Signaling
Renin-Angiotensin Signaling
Glucocorticoid Receptor Signaling
Hepatic Fibrosis / Hepatic Stellate Cell Activation

GeneDecks AGT for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for AGT

5/99 Interacting proteins for AGT (ENSP00000355627³ P01019²) via UniProtKB, MINT, and/or STRING (see all 99 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AGTR1	ENSP00000273430³	STRING (score=.999)
AGTR2	ENSP00000360973³	STRING (score=.998)
ACE	ENSP00000290866³	STRING (score=.993)
REN	ENSP00000272190³	STRING (score=.966)
ACE2	ENSP00000252519³	STRING (score=.962)

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5/54 Gene Ontology (GO) biological process terms (links to tree view) (see all 54 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001543	ovarian follicle rupture	IEA	--
GO:0001558	regulation of cell growth	NAS	17159080
GO:0001568	blood vessel development	IEA	--
GO:0001658	ureteric bud branching	IEA	--
GO:0001819	positive regulation of cytokine production	TAS	17906677

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for AGT available from Tocris Bioscience

Compound	Action	CAS number
Flupirtine maleate	K+ channel activator	[75507-68-5]
ZD 7155 hydrochloride	Selective non-peptide AT1 antagonist	[146709-78-6]
PD 123319 ditrifluoroacetate	Potent, selective non-peptide AT2 antagonist	[130663-39-7]
Y-27632 dihydrochloride	Selective p160ROCK inhibitor	[146986-50-7]

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10/62 Novoseek chemical compound relationships for AGT gene (see all 62 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
o6-methylguanine	59.41	24	14615965 (3), 1423888 (3), 2328502 (2), 7519972 (2) (see all 8)
aliskiren	58.50	2	11799102 (1)
sele	57.68	2	11341749 (1), 15076187 (1)
nadph	49.96	38	17553505 (3), 15894894 (3), 14652666 (3), 19059306 (2) (see all 20)
wortmannin	46.34	8	15652490 (1), 17404186 (1), 15317677 (1), 12763754 (1) (see all 8)
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine	44.90	1	17329403 (1)
cgp42112a	41.99	2	11692164 (1), 16286564 (1)
sodium	40.86	41	15138635 (5), 8864421 (5), 9468457 (3), 17428839 (2) (see all 18)
phosphatidylinositol	39.69	11	17404186 (2), 18401528 (2), 12624428 (1), 15138635 (1) (see all 8)
tyrosine	38.47	43	9774361 (3), 17510240 (3), 9648724 (2), 9486662 (2) (see all 28)

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1 PharmGKB drug compound relationship for AGT gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
glucocorticoids	FA	8613188

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AGT)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AGT)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000029

Sigma-Aldrich siRNA and siRNA Panels for AGT

Sigma-Aldrich shRNA Panels and shRNA for AGT

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000029

REFSEQ mRNAs for AGT gene:

NM_000029.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000029

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000029
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000029
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000029

Additional cDNA sequence:

AB209769.1 AK222798.1 AK222815.1 AK293507.1 AK303755.1 AK307978.1 AK312291.1 BC011519.1

BT006851.1 CR591984.1 CR592799.1 CR595628.1 CR601683.1 CR606672.1 CR607896.1 CR607898.1

CR615493.1 CR615499.1 CR618295.1 CR618811.1 CR618903.1 CR619790.1 CR625369.1 CR625415.1

K02215.1 M69110.1

20 DOTS entries:

DT.95161596 DT.100882586 DT.320302 DT.100882604 DT.100882590 DT.100882596 DT.100882597 DT.100882601

DT.121461228 DT.95161591 DT.100882579 DT.121461231 DT.100841842 DT.121461248 DT.121461281 DT.121461293

DT.121461297 DT.100882584 DT.308052 DT.92449717

24/619 AceView cDNA sequences (see all 619 ):

AA300076 AL531991 T17343 CR601683 CB138245 NM_000029 AL531926 CR625369

CR595628 CR607898 AV704206 BX367012 CB152924 AL532256 BM704182 CR619790

T91055 BI760360 CR615493 BX448662 BG059946 CR615499 CR607896 BX443943

highest scoring ESTs for AGT:

K02215 AA324741 AU116883 AU120430 AU279890 AW950905 BC011519 BG699056 BG700285 BG700639

Unigene Cluster for AGT:

Angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

Hs.19383 [show with all ESTs]

Unigene Representative Sequence: NM_000029

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for AGT

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6
SP1:
SP2:

About this scheme

ECgene alternative splicing isoforms for AGT

1 Ensembl transcript including schematic representation:

ENST00000366667

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AGT expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AGT

¹ / ² / ³

3 probe-sets matching AGT gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
684_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	K02215	1.00	1.00	1.00	1
202834_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000029	0.60	1.00	0.82	1
202834_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks AGT for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAGTGAGCAG

SOURCE GeneReport for Unigene cluster: Hs.19383
Expression variation in blood from EXPOLDB for AGT
UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019
Tissue specificity: Expressed by the liver and secreted in plasma

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AGT gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AGT¹	--	angiotensinogen (serpin peptidase inhibitor, clade more	77.2(n) 67.78(a)	403783 XM_536348.2 XP_536348.2
chimpanzee (Pan troglodytes)	AGT¹	--	angiotensinogen (serpin peptidase inhibitor, clade more	98.63(n) 98.97(a)	450104 NM_001009032.1 NP_001009032.1
rat (Rattus norvegicus)	Agt¹	--	angiotensinogen (serpin peptidase inhibitor, clade more	72.89(n) 64.33(a)	24179 NM_134432.2 NP_602308.1
mouse (Mus musculus)	Agt^{1, 5}	8 (68.00 cM)⁵	angiotensinogen (serpin peptidase inhibitor, clade more^{1, 5}	71.29(n)¹ 60.92(a)¹	11606¹ NM_007428.3¹ NP_031454.3¹ AF045883⁵ AF045884⁵ (see all 22)
chicken (Gallus gallus)	AGT¹	--	angiotensinogen (serpin peptidase inhibitor, clade more	52.85(n) 40.13(a)	421543 XM_419584.2 XP_419584.1

About this table Species with no ortholog for AGT

ENSEMBL Gene Tree for AGT

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AGT gene

SERPINA10² SERPIND1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/245 NCBI SNPs in AGT are shown (see all 245 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 140)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs5046^1,2	A,C,F,H,O	228917021(-)	`GTTTTC/TCCCAG`	1	--	ng3¹ tfbs³		13	MN EA NS EU WA NA	2576
	rs2071406^1,2	A,C,F,H	228917264(-)	`TATAAT/CGACTA`	1	--	ng3¹		10	NS EU EA WA	926
	rs2071405^1,2	A,C,F,H	228917281(-)	`TCTCTG/ATCATG`	1	--	ng3¹		13	NS EU EA WA NA	1076
	rs5051^1,2	A,C,F,H	228916495(+)	`TCCCCT/CGGCCG`	1	--	ut5¹ ese³ trp³		13	MN NS EA NA WA	1434
	rs5049^1,2	A,C,F,O	228916706(-)	`GCACCG/AGCTCA`	1	--	ut5¹		11	MN NS EA NA	1066
	rs699^1,2	A,C,F,H	228912417(-)	`CCTGAC/TGGGAG`	1	M/T	mis¹		17	MN EA NS NA EU WA	4864
--	rs5050^1,2	A,C,F,H	228916509(+)	`CACGAT/GGCCCT`	1	--	ut5¹ ese³		15	MN EA NA NS EU WA	1418
	rs2071404^1,2	A,C,F,H	228917563(-)	`TTGTTG/TATTGT`	1	--	ng3¹		11	EA NS EU WA	2410
	rs11568048^1,2	C,F,H	228918538(-)	`GCCTTA/CCGTAG`	1	--	ng3¹		5	NS EU EA WA	458
	rs11122580^1,2	C,F,H	228917667(-)	`aaagtA/Gattaa`	1	--	ng3¹		9	NS EU EA WA NA	624

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HapMap Linkage Disequilibrium images for AGT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 106150

UniProtKB/Swiss-Prot: ANGT_HUMAN, P01019

Defects in AGT are associated with susceptibility to essential hypertension [MIM:145500].

Hypertension also occurs in 5-7% of all pregnancies where it is a leading cause of maternal, fetal

and neonatal morbidity and mortality. Among pregnancy-induced hypertension cases, severe

pre-eclampsia [MIM:189800] is characterized by the development of hypertension and proteinuria

after the 20th week of pregnancy and is the most distinctive, life-threatening form

Defects in AGT are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an

autosomal recessive severe disorder of renal tubular development characterized by persistent fetal

anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios

(the Potter phenotype)

10/77 Novoseek disease relationships for AGT gene (see all 77 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
essential hypertension	74.97	75	9403548 (5), 18250562 (3), 15630592 (3), 11345362 (2) (see all 49)
hypertrophy	56.58	37	11758242 (5), 18559349 (3), 8943498 (2), 10419063 (1) (see all 24)
renal disease	52.70	28	10699153 (3), 12728975 (2), 9452999 (1), 11399656 (1) (see all 21)
atherosclerosis	51.97	32	11033054 (3), 16908765 (2), 10532681 (2), 12743015 (2) (see all 23)
diabetic nephropathies	50.67	15	10499884 (3), 12728975 (3), 11717948 (2), 10997697 (1) (see all 10)
cardiovascular diseases	49.89	23	11345362 (1), 16033904 (1), 16531750 (1), 16513650 (1) (see all 18)
renal fibrosis	48.03	4	17989112 (2), 12471481 (1), 9316214 (1)
gitelman syndrome	47.04	3	11316245 (1), 12897089 (1), 15361768 (1)
preeclampsia	46.27	27	9813426 (4), 18645251 (3), 16052407 (2), 12450315 (2) (see all 11)
cardiac hypertrophy	44.45	7	10342781 (2), 11120697 (1), 14717335 (1), 2386231 (1) (see all 5)

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Genatlas disease: AGT

hypertension associated with molecular variants of angiotensinogen,including pregnancy-induced

hypertension (preeclampsia),also increased risk of coronary heart disease (T174M and M235

variants),excluded at least in a population of Australian Anglo-Celtic Caucasians

Human Gene Mutation Database: AGT
Genetic Association Database: AGT
Human Genome Epidemiology Navigator: AGT (494 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1097 PubMed articles for AGT gene (see all 1097 ):

Primary structure of human preangiotensinogen deduced from the cloned cDNA sequence. (PubMed id 6089875)^{2, 3, 4} Kageyama R.... Nakanishi S. (1984)
Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease: a case-control study. (PubMed id 11754397)^{1, 3, 6} Tang D.C....Rodgers G.P. (2001)
[Studies of the association between angiotensinogen gene regulation and cytokines in essential hypertension] (PubMed id 14669517)^{1, 3, 6} Wang A.L....Chen S. (2003)
Association between angiotensinogen gene M235T polymorphism and mitral valve prolapse syndrome in Taiwan Chinese. (PubMed id 12479284)^{1, 3, 6} Chou H.T....Tsai F.J. (2002)
Association of angiotensinogen M235T and A(-6)G gene polymorphisms with coronary heart disease with independence of essential hypertension: the PROCAGENE study. Prospective Cardiac Gene. (PubMed id 11345362)^{1, 3, 6} Rodriguez-Perez J.C....Ferrario C.M. (2001)
The association study of DRD2, ACE and AGT gene polymorphisms and metamphetamine dependence. (PubMed id 11300226)^{1, 3, 6} Sery O....Zvolsky P. (2001)
[Association of angiotensinogen gene M235T variant with essential hypertension] (PubMed id 15067738)^{1, 3, 6} Cai S.Y....Shi Y.P. (2004)
[Association between angiotensin system gene polymorphism and essential hypertension] (PubMed id 11484170)^{1, 3, 6} Li X....Han X. (2001)
[Pharmacogenetics of angiotensin system in non diabetic nephropathy] (PubMed id 16231503)^{1, 3, 6} Coto E....Campistol J.M. (2005)
The Glu298Asp variant of the endothelial nitric oxide synthase gene is associated with an increased risk for abruptio placentae in pre-eclampsia. (PubMed id 16059745)^{1, 3, 6} Hillermann R....Gebhardt G.S. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 183	HGNC: 333	AceView: AGT	Ensembl:ENSG00000135744	euGenes: HUgn183
ECgene: AGT	H-InvDB: AGT

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=AGT
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=AGT
Wikipedia	http://en.wikipedia.org/wiki/Angiotensin

Licensable Technologies for AGT
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AGT:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AGT-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AGT		Antibodies for AGT
	Explore super-pooled esiRNAs		Proteins for AGT
	Lentivirus-delivered shRNAs for AGT		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (AGT)
	Antibodies (AGT)
	Chimera RNAi (AGT)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Angiotensin III, Angiotensin II, Angiotensin I)
	Antibodies (Angiotensin III, Angiotensin II, Angiotensin I)

Search OriGene for AGT

Tocris compounds for AGT

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for AGT

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
AGT Gene at Home site.
Version 2.41.1
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AGT Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for AGT

Summaries
for AGT

Genomic Location
for AGT

Proteins
for AGT

Protein Domains/
Families
for AGT

Gene Function
for AGT

Pathways & Interactions
for AGT

Drugs & Compounds
for AGT

Transcripts
for AGT

Expression
for AGT

Orthologs
for AGT

Paralogs
for AGT

SNPs/Variants
for AGT

Disorders & Mutations
for AGT

Medical News
for AGT

Publications
for AGT

Search for AGT

Genome Databases showing AGT

Other Databases showing AGT

Specialized Databases showing AGT

Licensable Technologies
for AGT

Services
for AGT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AGT Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor AGT

Summariesfor AGT

Genomic Locationfor AGT

Proteinsfor AGT

Protein Domains/Familiesfor AGT

Gene Functionfor AGT

Pathways & Interactionsfor AGT

Drugs & Compoundsfor AGT

Transcriptsfor AGT

Expression for AGT

Orthologsfor AGT

Paralogsfor AGT

SNPs/Variantsfor AGT

Disorders & Mutationsfor AGT

Medical Newsfor AGT

Publicationsfor AGT

Search for AGT

Genome Databases showing AGT

Other Databases showing AGT

Specialized Databases showing AGT

Licensable Technologiesfor AGT

Servicesfor AGT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AGT

Summaries
for AGT

Genomic Location
for AGT

Proteins
for AGT

Protein Domains/
Families
for AGT

Gene Function
for AGT

Pathways & Interactions
for AGT

Drugs & Compounds
for AGT

Transcripts
for AGT

Expression
for AGT

Orthologs
for AGT

Paralogs
for AGT

SNPs/Variants
for AGT

Disorders & Mutations
for AGT

Medical News
for AGT

Publications
for AGT

Licensable Technologies
for AGT

Services
for AGT