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AGRP Gene

protein-coding   GIFtS: 61
GCID: GC16M067516

Agouti Related Protein Homolog (Mouse)

(Previous name: agouti (mouse) related protein)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Agouti Related Protein Homolog (Mouse)1 2
AGRT2 3 5
ART2 3 5
Agouti (Mouse) Related Protein1
ASIP22
Agouti-Related Protein2

External Ids:    HGNC: 3301   Entrez Gene: 1812   Ensembl: ENSG000001597237   OMIM: 6023115   UniProtKB: O002533   

Export aliases for AGRP gene to outside databases

Previous GC identifers: GC16M058210 GC16M067894 GC16M067251 GC16M067292 GC16M066073 GC16M053389


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AGRP Gene:
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate
hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and
thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.
(provided by RefSeq, Dec 2009)

GeneCards Summary for AGRP Gene:
AGRP (agouti related protein homolog (mouse)) is a protein-coding gene. Diseases associated with AGRP include obesity, late-onset, and overnutrition. GO annotations related to this gene include neuropeptide hormone activity and receptor binding.

UniProtKB/Swiss-Prot: AGRP_HUMAN, O00253
Function: Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central
melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production
mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low
activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their
constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner

Gene Wiki entry for AGRP (Agouti-related peptide) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the AGRP gene promoter:
         CREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAGRP promoter sequence
   Search Chromatin IP Primers for AGRP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGRP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22

AGRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGRP gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M067516:  view genomic region     (about GC identifiers)

Start:
67,516,474 bp from pter      End:
67,517,716 bp from pter
Size:
1,243 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AGRP_HUMAN, O00253 (See protein sequence)
Recommended Name: Agouti-related protein precursor  
Size: 132 amino acids; 14440 Da
Subunit: Interacts with melanocortin receptors MC3R, MC4R and MC5R
3 PDB 3D structures from and Proteopedia for AGRP:
1HYK (3D)        1MR0 (3D)        2IQV (3D)    
Secondary accessions: O15459 Q2TBD9

Explore the universe of human proteins at neXtProt for AGRP: NX_O00253

Explore proteomics data for AGRP at MOPED


See AGRP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001129.1  
ENSEMBL proteins: 
 ENSP00000290953  

AGRP Human Recombinant Protein Products:

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OriGene Purified Protein for AGRP
OriGene Protein Over-expression Lysate for AGRP
OriGene MassSpec for AGRP
OriGene Custom Protein Services for AGRP
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Novus Biologicals AGRP Lysates
Sino Biological Recombinant Protein for AGRP
Sino Biological Cell Lysate for AGRP
ProSpec Recombinant Protein for AGRP
Cloud-Clone Corp. Proteins for AGRP

AGRP Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of AGRP
R&D Systems Antibodies for AGRP (AgRP/ART)
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OriGene Custom Antibody Services for AGRP
Novus Biologicals AGRP Antibodies
Abcam antibodies for AGRP
Cloud-Clone Corp. Antibodies for AGRP
Search ThermoFisher Antibodies for AGRP
LSBio Antibodies in human, mouse, rat for AGRP

AGRP Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for AGRP
R&D Systems ELISAs for AGRP (AgRP/ART)
GenScript Custom Assay Services for AGRP
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for AGRP
Cloud-Clone Corp. CLIAs for AGRP


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands

2 InterPro protein domains:
 IPR027300 Agouti_dom
 IPR007733 Agouti

Graphical View of Domain Structure for InterPro Entry O00253

ProtoNet protein and cluster: O00253

1 Blocks protein domain: IPB007733 Agouti

UniProtKB/Swiss-Prot: AGRP_HUMAN, O00253
Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin
Similarity: Contains 1 agouti domain


AGRP for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: AGRP_HUMAN, O00253
Function: Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central
melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production
mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low
activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their
constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner

     Genatlas biochemistry entry for AGRP:
mouse agouti related protein,primarily expressed in adrenal gland,subthalamic mucleus,hypothalamus,potent
antagonist of melanocortin receptor MICR3,MICR4, implicated in body weight regulation

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005102receptor binding TAS10318826
GO:0005184neuropeptide hormone activity IDA15927146
     
AGRP for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for AGRP:
 Increased gamma-H2AX phosphory 

     10 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Agrp):
 adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  liver/biliary system 
 mortality/aging  nervous system  no phenotypic analysis  normal  reproductive system 

AGRP for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for AGRP: Agrp/Atp6v0d1Agrp/tm1Rpa Agrptm1Sqn

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AGRP
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AGRP

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AGRP
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AGRP

miRNA
Products:
    
miRTarBase miRNAs that target AGRP:
hsa-mir-335-5p (MIRT018298)

Block miRNA regulation of human, mouse, rat AGRP using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate AGRP:
hsa-miR-133a hsa-miR-133b
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for AGRP
Predesigned siRNA for gene silencing in human, mouse, rat AGRP

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for AGRP

Clone
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OriGene clones in human, mouse for AGRP (see all 10)
OriGene ORF clones in mouse, rat for AGRP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: AGRP (NM_001138)
Sino Biological Human cDNA Clone for AGRP
DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGRP
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGRP

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for AGRP
Browse ESI BIO Cell Lines and PureStem Progenitors for AGRP 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGRP


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
AGRP_HUMAN, O00253: Secreted. Golgi apparatus lumen
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
golgi apparatus5
nucleus3

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IDA15927146
GO:0005796Golgi lumen IDA15927146
GO:0043025neuronal cell body IEA--

AGRP for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for AGRP About    
See pathways by source

SuperPathContained pathways About
1Syndecan-3-mediated signaling events
Syndecan-3-mediated signaling events
2Adipocytokine signaling pathway
Adipocytokine signaling pathway
3Adenylate cyclase activating neuropeptides
Adenylate cyclase activating neuropeptides

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for AGRP
    Syndecan-3-mediated signaling events



1 Kegg Pathway  (Kegg details for AGRP):
    Adipocytokine signaling pathway


AGRP for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Array including AGRP: 
          Obesity in human mouse rat

Interactions:

    GeneGlobe Interaction Network for AGRP

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

Selected Interacting proteins for AGRP (O002533 ENSP000002909534) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
InteractantInteraction Details
GeneCardExternal ID(s)
MC4RP322453, ENSP000002997664I2D: score=2 STRING: ENSP00000299766
MC3RP419683, ENSP000002439114I2D: score=1 STRING: ENSP00000243911
MC5RP330323, ENSP000003180774I2D: score=1 STRING: ENSP00000318077
GHRLQ9UBU33, ENSP000003350744I2D: score=1 STRING: ENSP00000335074
POMCENSP000002647084STRING: ENSP00000264708
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Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007218neuropeptide signaling pathway IDA15927146
GO:0007631feeding behavior TAS9751529
GO:0008343adult feeding behavior IEA--
GO:0009648photoperiodism IEA--
GO:0009755hormone-mediated signaling pathway IEA--

AGRP for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for AGRP

Selected Novoseek inferred chemical compound relationships for AGRP gene (see all 14)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
alpha msh 82.9 7 10902813 (2), 10657511 (1), 9751529 (1), 15481810 (1) (see all 6)
oxyntomodulin 69.6 2 15082874 (1)
cocaine 57.5 19 16210367 (2), 18061414 (1), 18971258 (1), 10657511 (1) (see all 18)
tcep 53.3 1 9724530 (1)
cystine 50.7 2 16009463 (1), 15509165 (1)
acth 36.7 11 12697678 (5), 16914082 (1), 14694081 (1), 17208361 (1)
glucose 24.7 46 17974626 (5), 19770186 (3), 20404050 (3), 15375032 (3) (see all 12)
amphetamine 13.6 3 10657511 (1), 15777192 (1), 16935329 (1)
n-ethylmaleimide 12.2 1 9724530 (1)
2-deoxyglucose 10.2 13 15375032 (3), 16978589 (1)



AGRP for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for AGRP gene: 
NM_001138.1  

Unigene Cluster for AGRP:

Agouti related protein homolog (mouse)
Hs.104633  [show with all ESTs]
Unigene Representative Sequence: BG460788
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000290953(uc002etg.1)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat AGRP using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate AGRP:
hsa-miR-133a hsa-miR-133b
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for AGRP
Predesigned siRNA for gene silencing in human, mouse, rat AGRP
Clone
Products:
     
OriGene clones in human, mouse for AGRP (see all 10)
OriGene ORF clones in mouse, rat for AGRP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: AGRP (NM_001138)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGRP
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGRP
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for AGRP
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AGRP
  QuantiTect SYBR Green Assays in human, mouse, rat AGRP
  QuantiFast Probe-based Assays in human, mouse, rat AGRP

Additional mRNA sequence: 

BC110443.2 U88063.1 U89485.1 

2 DOTS entries:

DT.307995  DT.95152059 

11 AceView cDNA sequences:

NM_001138 AI572835 NM_007316 CD369732 AW135422 U89485 AI823322 H63735 
H63298 AI572816 BU428489 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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AGRP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATCCCTGCA
AGRP Expression
About this image


AGRP expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Brain (Nervous System)    fully expand to see all 10 entries
         Thalamus
         Septum   
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Bone marrow-derived mesenchymal stem cells
 
 Mesenchymal Stem Cells
         Bone marrow-derived mesenchymal stem cells
 
 Eye (Sensory Organs)
         Retina
AGRP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

AGRP Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.104633

UniProtKB/Swiss-Prot: AGRP_HUMAN, O00253
Tissue specificity: Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower
level of expression occurring in testis, lung, and kidney

    Pathway & Disease-focused RT2 Profiler PCR Array including AGRP: 
          Obesity in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for AGRP
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AGRP
QuantiTect SYBR Green Assays in human, mouse, rat AGRP
QuantiFast Probe-based Assays in human, mouse, rat AGRP
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGRP

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for AGRP gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Agrp1 , 5 agouti related protein1, 5 82.44(n)1
80.92(a)1
  8 (53.04 cM)5
116041  NM_001271806.11  NP_001258735.11 
 1055667005 
chicken
(Gallus gallus)
Aves LOC1008596221 agouti-related protein-like 59.54(n)
50.38(a)
  100859622  XM_004950992.1  XP_004951049.1 
zebrafish
(Danio rerio)
Actinopterygii agrp6
agouti related protein homolog
33(a)
1 ↔ 1
7(36535830-36537982) ENSDARG00000069089


ENSEMBL Gene Tree for AGRP (if available)
TreeFam Gene Tree for AGRP (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for AGRP gene
1 SIMAP similar gene for AGRP using alignment to 1 protein entry:     AGRP_HUMAN:
AgRP

AGRP for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for AGRP (see all 54)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1437040821,2
C--67517173(+) TGACCT/CGGGAG 2 /P syn11Minor allele frequency- C:0.00NA 2796
rs341235231,2
C,F,H--67517179(-) CCAGAG/ACTCCC 2 /E syn121Minor allele frequency- A:0.14NS EA NA CSA WA 5038
rs1876269001,2
C--67517308(+) GCCTGA/GCTCAG 1 -- int10--------
rs350796051,2
C,F,H--67517538(-) GGAAGG/AGTCCT 1 -- ut5112Minor allele frequency- A:0.01NS EA NA 1530
rs340188971,2
C,F--67517638(-) TCCTGG/AAAACC 1 -- ut515Minor allele frequency- A:0.01MN 404
rs1892490821,2
--67517712(+) CCTAGG/TAGCTG 1 -- ut510--------
rs1817998511,2
C--67517713(+) CTAGGA/TGCTGA 1 -- ut510--------
rs50309811,2
C,F--67517754(-) AGGGCC/TGCCTG 1 -- us2k113Minor allele frequency- T:0.18MN NS NA WA 687
rs347315561,2
F--67517759(-) CTTTCA/GGGGCY 1 -- us2k15Minor allele frequency- G:0.01MN 404
rs1485841011,2
--67517791(+) AGAGAA/TGCTTA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for AGRP (67516474 - 67517716 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for AGRP:    About this table    
Variant IDTypeSubtypePubMed ID
nsv524363CNV Loss19592680
nsv833266CNV Loss17160897
nsv471092CNV Gain18288195
nsv522852CNV Gain19592680

Human Gene Mutation Database (HGMD): AGRP
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing AGRP
DNA2.0 Custom Variant and Variant Library Synthesis for AGRP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 602311   
OMIM disorders: 601665  
UniProtKB/Swiss-Prot: AGRP_HUMAN, O00253
  • Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the
    limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
    Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

  • 20 diseases for AGRP:    
    About MalaCards
    obesity, late-onset    overnutrition    leanness, inherited    eating disorder
    anorexia nervosa    fatty liver disease    prader-willi syndrome    morbid obesity
    obesity    autism spectrum disorder    hypothyroidism    cushing's syndrome
    liver disease    hyperglycemia    thyroiditis    multiple myeloma
    myeloma    neuronitis    retinitis    pancreatitis


    AGRP for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for AGRP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 68 34 11344185 (3), 10371151 (2), 19602223 (2), 11487744 (2) (see all 19)
    anorexia nervosa 55.1 6 12536362 (1), 16904835 (1), 16314751 (1), 17197106 (1) (see all 6)
    prader-willi syndrome 37 1 11836343 (1)
    eating disorders 27.8 1 16904835 (1)
    chronic disease 5.26 1 18583425 (1)
    tumors 0.815 1 20124048 (1)
    hypothyroidism 0 1 12239096 (1)
    inflammation 0 3 12697678 (1), 18583425 (1)

    Genetic Association Database (GAD): AGRP
    Human Genome Epidemiology (HuGE) Navigator: AGRP (14 documents)

    Export disorders for AGRP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AGRP gene, integrated from 10 sources (see all 210):
    (articles sorted by number of sources associating them with AGRP)
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    1. Association between an agouti-related protein gene polymorphism and anorexia nervosa. (PubMed id 11326303)1, 2, 4, 9 Vink T.... Adan R.A. (Mol. Psychiatry 2001)
    2. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. (PubMed id 9311920)1, 2, 3, 9 Ollmann M.M....Barsh G.S. (Science 1997)
    3. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. (PubMed id 9119224)1, 2, 3 Shutter J.R....Stark K.L. (Genes Dev. 1997)
    4. NMR structure of a minimized human agouti related protein prepared by total chemical synthesis. (PubMed id 10371151)1, 2, 9 Bolin K.A.... Millhauser G.L. (FEBS Lett. 1999)
    5. Characterization of Agouti-related protein binding to melanocortin receptors. (PubMed id 9892020)1, 2, 9 Yang Y.K.... Gantz I. (Mol. Endocrinol. 1999)
    6. Determination of disulfide structure in agouti-related protein (AGRP) by stepwise reduction and alkylation. (PubMed id 9724530)1, 2, 9 Bures E.J.... Haniu M. (Biochemistry 1998)
    7. Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: association with subtype, body-mass index, severity and age of onset. (PubMed id 17197106)1, 4, 9 Dardennes R.M....Epelbaum J. (Psychoneuroendocrinology 2007)
    8. Two ethnic-specific polymorphisms in the human Agouti-related protein gene are associated with macronutrient intake. (PubMed id 16280444)1, 4, 9 Loos R.J....Argyropoulos G. (Am. J. Clin. Nutr. 2005)
    9. Association between a rare SNP in the second intron of human Agouti related protein gene and increased BMI. (PubMed id 19602223)1, 4, 9 Kalnina I....Klovins J. (BMC Med. Genet. 2009)
    10. Polymorphisms in the NPY and AGRP genes and body fatness in Dutch adults. (PubMed id 16568137)1, 4, 9 van Rossum C.T....Seidell J.C. (Int J Obes (Lond) 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 181 HGNC: 330 AceView: AGRP Ensembl:ENSG00000159723 euGenes: HUgn181
    ECgene: AGRP Kegg: 181 H-InvDB: AGRP

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AGRP Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/agrp/

    (Patent information from GeneIP,
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    Patent Information for AGRP gene:
    Search GeneIP for patents involving AGRP

    GeneCards and IP:
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