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Aliases for AGR3 Gene

Aliases for AGR3 Gene

  • Anterior Gradient 3, Protein Disulphide Isomerase Family Member 2 3 5
  • Breast Cancer Membrane Protein 11 2 3 4
  • Protein Disulfide Isomerase Family A, Member 18 3 4
  • BCMP11 3 4
  • PDIA18 3 4
  • HAG-3 3 4
  • AG-3 3 4
  • AG3 3 4
  • Anterior Gradient 3 Homolog (Xenopus Laevis) 2
  • Protein Disulfide Isomerase Family A 2
  • Anterior Gradient Protein 3 Homolog 3
  • Anterior Gradient Homolog 3 3
  • Anterior Gradient 3 Homolog 4
  • Member 18 2
  • HAG3 3

External Ids for AGR3 Gene

Previous GeneCards Identifiers for AGR3 Gene

  • GC07M016866
  • GC07M016899

Summaries for AGR3 Gene

GeneCards Summary for AGR3 Gene

AGR3 (Anterior Gradient 3, Protein Disulphide Isomerase Family Member) is a Protein Coding gene. Diseases associated with AGR3 include Breast Abscess and Ritter's Disease. GO annotations related to this gene include dystroglycan binding. An important paralog of this gene is TXNDC12.

UniProtKB/Swiss-Prot for AGR3 Gene

  • Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.

Gene Wiki entry for AGR3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGR3 Gene

Genomics for AGR3 Gene

Regulatory Elements for AGR3 Gene

Enhancers for AGR3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AGR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for AGR3 Gene

16,854,728 bp from pter
16,881,989 bp from pter
27,262 bases
Minus strand

Genomic View for AGR3 Gene

Genes around AGR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGR3 Gene

Proteins for AGR3 Gene

  • Protein details for AGR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Anterior gradient protein 3
    Protein Accession:
    Secondary Accessions:
    • A4D120

    Protein attributes for AGR3 Gene

    166 amino acids
    Molecular mass:
    19171 Da
    Quaternary structure:
    • Interacts with LYPD3 and DAG1 (alphaDAG1).

    Three dimensional structures from OCA and Proteopedia for AGR3 Gene

neXtProt entry for AGR3 Gene

Proteomics data for AGR3 Gene at MOPED

Post-translational modifications for AGR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for AGR3 Gene

Domains & Families for AGR3 Gene

Gene Families for AGR3 Gene

Protein Domains for AGR3 Gene


Suggested Antigen Peptide Sequences for AGR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AGR family.
  • Belongs to the AGR family.
genes like me logo Genes that share domains with AGR3: view

Function for AGR3 Gene

Molecular function for AGR3 Gene

UniProtKB/Swiss-Prot Function:
Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.
UniProtKB/Swiss-Prot Induction:
Not induced as part of the cellular response to endoplasmic reticulum stress (PubMed:25751668). Up-regulated by androgens and by estrogens in prostate cancer cells (PubMed:23294566) Up-regulated by a hormone (estrogen-receptor alpha) independent mechanism in ovarian cancer (PubMed:22361111).

Gene Ontology (GO) - Molecular Function for AGR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002162 dystroglycan binding IDA 12592373
genes like me logo Genes that share ontologies with AGR3: view

Phenotypes for AGR3 Gene

GenomeRNAi human phenotypes for AGR3:
genes like me logo Genes that share phenotypes with AGR3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AGR3

miRNA for AGR3 Gene

miRTarBase miRNAs that target AGR3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGR3 Gene

Localization for AGR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGR3 Gene

Endoplasmic reticulum. Note=Found in the cytoplasm, which could include the endoplasmic reticulum. {ECO:0000305 PubMed:26170690}.

Subcellular locations from

Jensen Localization Image for AGR3 Gene COMPARTMENTS Subcellular localization image for AGR3 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 2

Gene Ontology (GO) - Cellular Components for AGR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with AGR3: view

Pathways & Interactions for AGR3 Gene

SuperPathways for AGR3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AGR3 Gene


No data available for Pathways by source and SIGNOR curated interactions for AGR3 Gene

Drugs & Compounds for AGR3 Gene

No Compound Related Data Available

Transcripts for AGR3 Gene

Unigene Clusters for AGR3 Gene

Anterior gradient 3 homolog (Xenopus laevis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGR3 Gene

No ASD Table

Relevant External Links for AGR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AGR3 Gene

mRNA expression in normal human tissues for AGR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGR3 Gene

This gene is overexpressed in Colon - Transverse (x17.0), Small Intestine - Terminal Ileum (x10.4), and Lung (x7.7).

Protein differential expression in normal tissues from HIPED for AGR3 Gene

This gene is overexpressed in Nasal epithelium (23.4), Oral epithelium (20.2), and Breast (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AGR3 Gene

SOURCE GeneReport for Unigene cluster for AGR3 Gene Hs.100686

mRNA Expression by UniProt/SwissProt for AGR3 Gene

Tissue specificity: Expressed in the lung, in the ciliated cells of the airway epithelium (PubMed:25751668). Expression increased with differentiation of airway epithelial cells (PubMed:25751668). Not detected in the mucous cells (PubMed:25751668). Expressed in ciliated cells in the oviduct (PubMed:26170690). Also detected in stomach, colon, prostate and liver (PubMed:25751668). Expressed in breast, ovary, prostate and liver cancer (PubMed:26170690). Expression is associated with the level of differentiation of breast cancer (at protein level) (PubMed:26170690).
genes like me logo Genes that share expression patterns with AGR3: view

Protein tissue co-expression partners for AGR3 Gene

- Elite partner

Primer Products

Orthologs for AGR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AGR3 35
  • 88.96 (n)
  • 90.96 (a)
AGR3 36
  • 91 (a)
(Mus musculus)
Mammalia Agr3 35
  • 85.86 (n)
  • 91.52 (a)
Agr3 16
Agr3 36
  • 92 (a)
(Pan troglodytes)
Mammalia AGR3 35
  • 98.8 (n)
  • 98.8 (a)
AGR3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Agr3 35
  • 86.06 (n)
  • 92.12 (a)
(Monodelphis domestica)
Mammalia AGR3 36
  • 60 (a)
(Gallus gallus)
Aves AGR3 35
  • 78.59 (n)
  • 86.06 (a)
AGR3 36
  • 86 (a)
(Anolis carolinensis)
Reptilia AGR3 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia agr3 35
  • 74.25 (n)
  • 78.62 (a)
Str.8536 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9044 35
(Danio rerio)
Actinopterygii zgc:165571 36
  • 59 (a)
(Caenorhabditis elegans)
Secernentea F49H12.5 36
  • 16 (a)
Y57A10A.23 36
  • 25 (a)
Species with no ortholog for AGR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGR3 Gene

Gene Tree for AGR3 (if available)
Gene Tree for AGR3 (if available)

Paralogs for AGR3 Gene

Paralogs for AGR3 Gene

(2) SIMAP similar genes for AGR3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with AGR3: view

Variants for AGR3 Gene

Sequence variations from dbSNP and Humsavar for AGR3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs940826 -- 16,854,692(-) ATTGA(C/T)TGTTT downstream-variant-500B
rs6949436 -- 16,871,815(+) ccagc(A/C)tggtg intron-variant
rs6950372 -- 16,872,348(+) acatg(A/C)attgg intron-variant
rs6951775 -- 16,855,274(+) tactg(A/G)gggat intron-variant
rs6957631 -- 16,874,942(+) tgtaa(C/T)ctgtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGR3 Gene

Variant ID Type Subtype PubMed ID
dgv7217n71 CNV Gain 21882294
nsv887764 CNV Gain 21882294
esv2752152 CNV Loss 17911159
nsv887766 CNV Gain 21882294
nsv522109 CNV Gain 19592680
dgv7218n71 CNV Gain 21882294
nsv887768 CNV Gain 21882294
nsv464398 CNV Gain 19166990
nsv522500 CNV Loss 19592680

Variation tolerance for AGR3 Gene

Residual Variation Intolerance Score: 54.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AGR3 Gene

Disorders for AGR3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for AGR3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
breast abscess
  • abscess of breast
ritter's disease
  • dermatitis exfoliativa neonatorum
- elite association - COSMIC cancer census association via MalaCards
Search AGR3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AGR3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with AGR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AGR3 Gene

Publications for AGR3 Gene

  1. hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. (PMID: 12592373) Fletcher G.C. … Terrett J.A. (Br. J. Cancer 2003) 2 3 4 23 67
  2. Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer. (PMID: 12477722) Adam P.J. … Terrett J.A. (J. Biol. Chem. 2003) 2 3
  3. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3
  4. The role of AGR2 and AGR3 in cancer: similar but not identical. (PMID: 25666661) Obacz J. … Hrstka R. (Eur. J. Cell Biol. 2015) 3
  5. The ER resident protein AGR3 is required for regulation of ciliary beat frequency in the airway. (PMID: 25751668) Bonser L.R. … Erle D.J. (Am. J. Respir. Cell Mol. Biol. 2015) 3

Products for AGR3 Gene

Sources for AGR3 Gene