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Aliases for AGR3 Gene

Aliases for AGR3 Gene

  • Anterior Gradient 3 2 3
  • Breast Cancer Membrane Protein 11 2 3 4
  • BCMP11 3 4 6
  • HAG-3 3 4
  • AG-3 3 4
  • AG3 3 4
  • Protein Disulfide Isomerase Family A, Member 18 3
  • Anterior Gradient 3 Homolog (Xenopus Laevis) 2
  • Protein Disulfide Isomerase Family A 2
  • Anterior Gradient Protein 3 Homolog 3
  • Anterior Gradient Homolog 3 3
  • Member 18 2
  • PDIA18 3
  • HAG3 3

External Ids for AGR3 Gene

Previous GeneCards Identifiers for AGR3 Gene

  • GC07M016866
  • GC07M016899

Summaries for AGR3 Gene

GeneCards Summary for AGR3 Gene

AGR3 (Anterior Gradient 3) is a Protein Coding gene. Diseases associated with AGR3 include breast cancer. GO annotations related to this gene include dystroglycan binding. An important paralog of this gene is TXNDC12.

Gene Wiki entry for AGR3 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGR3 Gene

Genomics for AGR3 Gene

Regulatory Elements for AGR3 Gene

Genomic Location for AGR3 Gene

Start:
16,859,405 bp from pter
End:
16,881,989 bp from pter
Size:
22,585 bases
Orientation:
Minus strand

Genomic View for AGR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGR3 Gene

Proteins for AGR3 Gene

  • Protein details for AGR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD06-AGR3_HUMAN
    Recommended name:
    Anterior gradient protein 3 homolog
    Protein Accession:
    Q8TD06
    Secondary Accessions:
    • A4D120

    Protein attributes for AGR3 Gene

    Size:
    166 amino acids
    Molecular mass:
    19171 Da
    Quaternary structure:
    • Interacts with LYPD3 and DAG1 (alphaDAG1).

    Three dimensional structures from OCA and Proteopedia for AGR3 Gene

neXtProt entry for AGR3 Gene

Proteomics data for AGR3 Gene at MOPED

Post-translational modifications for AGR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AGR3 Gene

Domains for AGR3 Gene

Gene Families for AGR3 Gene

HGNC:
  • PDI :Protein disulfide isomerases

Protein Domains for AGR3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AGR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TD06

UniProtKB/Swiss-Prot:

AGR3_HUMAN :
  • Q8TD06
Family:
  • Belongs to the AGR family.
genes like me logo Genes that share domains with AGR3: view

Function for AGR3 Gene

Gene Ontology (GO) - Molecular Function for AGR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002162 dystroglycan binding IDA 12592373
GO:0005515 protein binding IPI 12592373
genes like me logo Genes that share ontologies with AGR3: view

Animal Model Products

CRISPR Products

miRNA for AGR3 Gene

miRTarBase miRNAs that target AGR3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGR3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AGR3 Gene

Localization for AGR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGR3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGR3 Gene COMPARTMENTS Subcellular localization image for AGR3 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for AGR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with AGR3: view

Pathways for AGR3 Gene

SuperPathways for AGR3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AGR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with AGR3: view

No data available for Pathways by source for AGR3 Gene

Transcripts for AGR3 Gene

Unigene Clusters for AGR3 Gene

Anterior gradient 3 homolog (Xenopus laevis):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGR3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGR3 Gene

No ASD Table

Relevant External Links for AGR3 Gene

GeneLoc Exon Structure for
AGR3
ECgene alternative splicing isoforms for
AGR3

Expression for AGR3 Gene

mRNA expression in normal human tissues for AGR3 Gene

mRNA differential expression in normal tissues according to GTEx for AGR3 Gene

This gene is overexpressed in Colon - Transverse (17.0), Small Intestine - Terminal Ileum (10.4), and Lung (7.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for AGR3 Gene

SOURCE GeneReport for Unigene cluster for AGR3 Gene Hs.100686

genes like me logo Genes that share expressions with AGR3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for AGR3 Gene

Orthologs for AGR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGR3 35
  • 98.8 (n)
  • 98.8 (a)
AGR3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AGR3 35
  • 88.96 (n)
  • 90.96 (a)
AGR3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agr3 35
  • 85.86 (n)
  • 91.52 (a)
Agr3 16
Agr3 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGR3 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agr3 35
  • 86.06 (n)
  • 92.12 (a)
chicken
(Gallus gallus)
Aves AGR3 35
  • 78.59 (n)
  • 86.06 (a)
AGR3 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGR3 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agr3 35
  • 74.25 (n)
  • 78.62 (a)
Str.8536 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9044 35
zebrafish
(Danio rerio)
Actinopterygii zgc:165571 36
  • 59 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F49H12.5 36
  • 16 (a)
ManyToMany
Y57A10A.23 36
  • 25 (a)
ManyToMany
Species with no ortholog for AGR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGR3 Gene

ENSEMBL:
Gene Tree for AGR3 (if available)
TreeFam:
Gene Tree for AGR3 (if available)

Paralogs for AGR3 Gene

Paralogs for AGR3 Gene

Selected SIMAP similar genes for AGR3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with AGR3: view

Variants for AGR3 Gene

Sequence variations from dbSNP and Humsavar for AGR3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs11798 -- 16,859,573(-) ATGAT(A/G)GAAAA utr-variant-3-prime
rs2254186 -- 16,869,544(+) gcaac(A/G)tgatg intron-variant
rs2286212 -- 16,878,365(-) TTTTT(A/T)AAAAC intron-variant
rs2389710 -- 16,879,934(+) ATACT(A/G)TTTTC intron-variant
rs2428947 -- 16,868,258(-) gaatc(A/C/T)cttga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGR3 Gene

Variant ID Type Subtype PubMed ID
dgv7217n71 CNV Gain 21882294
nsv887764 CNV Gain 21882294
esv2752152 CNV Loss 17911159
nsv887766 CNV Gain 21882294
nsv522109 CNV Gain 19592680
dgv7218n71 CNV Gain 21882294
nsv887768 CNV Gain 21882294
nsv464398 CNV Gain 19166990
nsv522500 CNV Loss 19592680

Relevant External Links for AGR3 Gene

HapMap Linkage Disequilibrium report
AGR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGR3 Gene

Disorders for AGR3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for AGR3 Gene including...

Search for AGR3 Gene in MalaCards »

(2) University of Copenhagen DISEASES for AGR3 Gene

genes like me logo Genes that share disorders with AGR3: view

No data available for UniProtKB/Swiss-Prot for AGR3 Gene

Publications for AGR3 Gene

  1. hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. (PMID: 12592373) Fletcher G.C. … Terrett J.A. (Br. J. Cancer 2003) 2 3 4 23
  2. Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer. (PMID: 12477722) Adam P.J. … Terrett J.A. (J. Biol. Chem. 2003) 2 3 4
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4

Products for AGR3 Gene

Sources for AGR3 Gene

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