AGR3 Gene
protein-coding GIFtS: 49
GCID: GC07M016899
|
|
anterior gradient 3 homolog (Xenopus laevis)
| |
Aliases
for AGR3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Anterior Gradient 3 Homolog (Xenopus Laevis)1 2 | | AG-32 3 | | BCMP111 2 3 5 | | AG32 3 | | HAG-31 | | Anterior Gradient Homolog 32 | | HAG31 2 | | Anterior Gradient Protein 3 Homolog2 | | PDIA181 2 | | Protein Disulfide Isomerase Family A, Member 182 | | Breast Cancer Membrane Protein 112 3 | | |
Export aliases for AGR3 gene to outside databasesPrevious GC identifer: GC07M016866 |
Summaries
for AGR3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for AGR3
|
Genomic Views
for AGR3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AGR3 gene promoter:
TBP AML1a GATA-3 Brachyury GATA-1 GATA-2 AREB6 FOXJ2 (long isoform) Hand1 FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for AGR3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGR3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p21.1 Ensembl cytogenetic band: 7p21.1 HGNC cytogenetic band: 7p21.1AGR3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M016899: view genomic region
(about GC identifiers)
Start:
|
16,899,029 bp from pter |
End:
|
16,921,613 bp from pter |
Size:
|
22,585 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 16,952,702-16,975,263 |
|
Proteins
for AGR3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AGR3_HUMAN, Q8TD06 (See
protein sequence)Recommended Name: Anterior gradient protein 3 homolog precursor Size: 166 amino acids; 19171 Da
Subunit: Interacts with LYPD3 and DAG1 (alphaDAG1)
Subcellular location: Secreted (Probable)
1 PDB 3D structure from  and Proteopedia  for AGR3:3PH9 (3D)
Secondary accessions: A4D120Explore the universe of human proteins at neXtProt for AGR3: NX_Q8TD06
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TD06
AGR3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_789783.1
ENSEMBL proteins: ENSP00000308606 ENSP00000386016 ENSP00000392818
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
AGR3 for ontologies About GeneDecksing
AGR3 Antibody Products:
Assay Products for AGR3: |
Protein
Domains /
Families
for AGR3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AGR3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TD06ProtoNet protein and cluster: Q8TD06 UniProtKB/Swiss-Prot: AGR3_HUMAN, Q8TD06Similarity: Belongs to the AGR family |
Function
for AGR3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGR3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGR3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: AGR3 (NM_176813) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AGR3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGR3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
AGR3 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Agr3tm1Lex for AGR3
1 MGI phenotypic allele  for Agr3 (no phenotypes)
AGR3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for AGR3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AGR3
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for AGR3 (Q8TD063 ENSP000003086064) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for AGR3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AGR3
Search CenterWatch for drugs/clinical trials and news about AGR3
|
Transcripts
for AGR3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AGR3 gene: NM_176813.3 Unigene Cluster for AGR3: Anterior gradient 3 homolog (Xenopus laevis) Hs.100686 [show with all ESTs]Unigene Representative Sequence: BG5406174 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000310398(uc003sts.3) ENST00000402239 ENST00000414935 ENST00000486448
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGR3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGR3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AGR3 (NM_176813) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AGR3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGR3 |
Additional cDNA sequence: AY069977.1 AY359065.1 BC058284.1 3 DOTS entries: DT.307225 DT.102820496 DT.97781108 24/58 AceView cDNA sequences (see all 58): BM853449 CB136298 CB159832 CB147956 CB135039 AY359065 AA487468 BU682778 BM750389 CA444272 NM_176813 BX101706 BQ084302 BM848919 AW270969 AY069977 BE645984 AI432306 BF591295 AA487683 BM771587 AW015443 AI734150 AI906910
GeneLoc Exon Structure
|
Expression
for AGR3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AGR3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAAAACCT
About this image
See AGR3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AGR3
SOURCE GeneReport for Unigene cluster: Hs.100686
SABiosciences Custom PCR Arrays for AGR3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AGR3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AGR3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGR3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGR3 |
Orthologs
for AGR3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for AGR3 gene from 5/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
AGR31 |
anterior gradient homolog 3 (Xenopus laevis) |
78.59(n)
86.06(a) |
|
420597 NM_001199613.1 NP_001186542.1 |
lizard
(Anolis carolinensis) |
Reptilia |
AGR36 |
-- |
85(a) |
1 ↔ 1 |
6(27607196-27616686) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.85362 |
Transcribed sequence with weak similarity to protein more |
76.11(n) |
|
CF375204.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1655716 |
zgc:165571 |
60(a) |
possible ortholog |
9(46659480-46671250) |
worm
(Caenorhabditis elegans) |
Secernentea |
Y57A10A.236F49H12.56 |
Protein F49H12.5 |
23(a)15(a) |
many ↔ manymany ↔ many |
II(12240323-12242025) X(2074442-2075938) |
ENSEMBL Gene Tree for AGR3 (if available)
TreeFam Gene Tree for AGR3 (if available) |
Paralogs
for AGR3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AGR3 gene
- TXNDC122 AGR22
2 SIMAP similar genes for AGR3 using alignment to 3 protein entries: AGR3_HUMAN (see all proteins):AGR2 TXNDC12
AGR3 for paralogs About GeneDecksing
|
Genomic Variants
for AGR3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AGR3 (16899029 - 16921613 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for AGR3
2 CNVs: 34496 9051 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AGR3 |
|
Disorders
/ Diseases
for AGR3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AGR3 for disorders About GeneDecksing
OMIM gene information: 609482
OMIM disorders: --
4  diseases for AGR3: About MalaCardsbreast cancer ritter's disease impetigo ovarian cancer
1 disease from the University of Copenhagen DISEASES database for AGR3:Ritter's disease Export disorders for AGR3 gene to outside databases
|
Publications
for AGR3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AGR3 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with AGR3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. (PubMed id 12592373)1, 2, 3, 9 Fletcher G.C....Terrett J.A. (2003)
- Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer. (PubMed id 12477722)1, 2, 3 Adam P.J....Terrett J.A. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Anterior Gradient-3: a novel biomarker for ovarian can cer that mediates cisplatin resistance in xenograft models. (PubMed id 22361111)1 Gray T.A....Hupp T.R. (2012)
- The anterior gradient homolog 3 (AGR3) gene is associ ated with differentiation and survival in ovarian cancer. (PubMed id 21451362)1 King E.R....Wong K.K. (2011)
- 5' to 3' mRNA decay factors colocalize with Ty1 gag a nd human APOBEC3G and promote Ty1 retrotransposition. (PubMed id 20219921)1 Dutko J.A....Curcio M.J. (2010)
- Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family. (PubMed id 15935701)1 Persson S....Michalak M. (2005)
|
External Searches for AGR3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AGR3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AGR3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AGR3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AGR3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for AGR3 gene:
Search GeneIP for patents involving AGR3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AGR3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for AGR3 | | OriGene shRNA RFP for AGR3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AGR3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AGR3 | | | OriGene Protein Over-expression Lysate for AGR3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AGR3 | | OriGene 3'-UTR Clone for AGR3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGR3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGR3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for AGR3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for AGR3 | | OriGene Custom Protein Services for AGR3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AGR3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AGR3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGR3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGR3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGR3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGR3 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for AGR3 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | AGR3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibody for AGR3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGR3 |
|
|
|
|
