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Aliases & Descriptions for AGR2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| AG-2 3 | | AG2 1, 2, 3, 5 | | GOB-4 2 | | HAG-2 1, 2 | | HPC8 3 | | PDIA17 1, 2 | | XAG-2 1, 2 | | hAG-2 3 |
| | | Descriptions |
|---|
| Secreted cement gland protein XAG-2 homolog 3 | | anterior gradient 2 homolog 2 | | anterior gradient 2 homolog (Xenopus laevis) 1 | | anterior gradient homolog 2 (Xenopus laevis) 2 | | protein disulfide isomerase family A, member 17 2 | | secreted cement gland homolog 2 |
|
| | Search outside databases for aliases for AGR2 genePrevious GC identifers: GC07M016476 GC07M016575 GC07M016605 |
Summaries for AGR2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for AGR2 |
Genomic Location for AGR2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the AGR2 gene 
Entrez Gene cytogenetic band: 7p21.3 Ensembl cytogenetic band: 7p21.1 HGNC cytogenetic band: 7p21.3AGR2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M016797:
(about GC identifiers)
Start:
|
16,797,960 bp from pter |
End:
|
16,811,136 bp from pter |
Size:
|
13,177 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 16,885,092-16,898,265 |
RefSeq DNA sequence:- NC_000007.12 NT_007819.16 NT_079592.2
| Proteins for AGR2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: AGR2_HUMAN, O95994 (See
protein sequence)Recommended Name: Anterior gradient protein 2 homolog precursor Size: 175 amino acids; 19979 Da
Subunit: Interacts with LYPD3 and alpha-dystroglycan
Subcellular location: Secreted (Probable)REFSEQ proteins: NP_006399.1
ENSEMBL proteins: ENSP00000386025 ENSP00000223274
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for AGR2: Assays for AGR2: | Protein
Domains/ Families for AGR2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O95994
ProtoNet protein and cluster: O95994 UniProtKB/Swiss-Prot: AGR2_HUMAN, O95994Similarity: Belongs to the AGR family | Gene Function for AGR2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006408
Applied Biosystems Silencer® siRNAs for AGR2
Sigma-Aldrich siRNA for AGR2  Sigma-Aldrich shRNA for AGR2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006408                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006408                                  untagged cDNA clone in CMV expression vector: NM_006408 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006408
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Agr2):
| Pathways & Interactions for AGR2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for AGR2 
5/8 Interacting proteins for AGR2 (ENSP000002232743 O959942) via UniProtKB, MINT, and/or STRING (see all 8
)About this table
|
Drugs & Compounds for AGR2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for AGR2
|
Transcripts for AGR2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006408
Sigma-Aldrich siRNA for AGR2  Sigma-Aldrich shRNA for AGR2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006408 REFSEQ mRNAs for AGR2 gene: NM_006408.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006408               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006408                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006408                                  untagged cDNA clone in CMV expression vector: NM_006408  Additional cDNA sequence: AF007791.1 AF038451.1 AF038452.1 AF087879.1 AF088867.1 AF115926.1 AK124419.1 AK223067.1 AK296721.1 AK312942.1 AY359009.1 BC015503.1 BT007048.1 CR610899.1 18 DOTS entries: DT.100810938 DT.75105686 DT.95279263 DT.95092567 DT.121112254 DT.92007777 DT.121112258 DT.97860996 DT.99960432 DT.121112240 DT.121112251 DT.91752704 DT.95253542 DT.95279319 DT.121112245 DT.95279313 DT.97804195 DT.121112242 24/663 AceView cDNA sequences (see all 663
):BQ084526 AI249798 BM768900 BI770277 AW192135 BQ084070 BM854269 BM769244 BM790204 BM795284 BQ083985 BM796390 BM789904 BM796396 CB144392 BM856780 AW196067 BM791184 BM790980 BM765629 BM852535 BM828131 BX387240 AI445127
highest scoring ESTs for AGR2:AF038451 AA055880 AA298527 AA307795 AA313235 AA314146 AA314206 AA314372 AA315408 AA315613 Unigene Cluster for AGR2: Anterior gradient homolog 2 (Xenopus laevis) Hs.530009 [show with all ESTs]Unigene Representative Sequence: BM924878
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for AGR2 (see all 6
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for AGR2
2 Ensembl transcripts including schematic representations: ENST00000401412
ENST00000223274
|
Expression for AGR2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| AGR2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for AGR2
1 / 2 / 3 6 probe-sets matching AGR2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ATTTTCTAAA
SOURCE GeneReport for Unigene cluster: Hs.530009
Expression variation in blood from EXPOLDB for AGR2 UniProtKB/Swiss-Prot: AGR2_HUMAN, O95994Tissue specificity: Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines |
Orthologs for AGR2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AGR2 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for AGR2
ENSEMBL Gene Tree for AGR2 | Paralogs for AGR2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for AGR2 gene
- TXNDC122 AGR32
|
SNPs/Variants for AGR2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for AGR2 (up to first 250kb)
|
Disorders & Mutations for AGR2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606358
2 Novoseek disease relationships for AGR2 gene
About this table
Genetic Association Database: AGR2 Human Genome Epidemiology Navigator: AGR2 (1 document)
|
Medical News for AGR2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for AGR2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/27 PubMed articles for AGR2 gene (see all 27
):- hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines. (PubMed id 9790916)1, 2, 3, 4 Thompson D.A. and Weigel R.J. (1998)
- hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. (PubMed id 12592373)1, 3, 4 Fletcher G.C....Terrett J.A. (2003)
- Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease. (PubMed id 16222343)3, 6 Zheng W.... Hampe J. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)3, 4 Zhang Z. and Henzel W.J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)3, 4 Hillier L.W.... Wilson R.K. (2003)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)3, 4 Clark H.F....Gray A. (2003)
- Prognostic relevance of AGR2 expression in breast cancer. (PubMed id 16551856)1, 3 Fritzsche F.R....Kristiansen G. (2006)
- Anterior gradient-2 is overexpressed by fibrolamellar carcinomas. (PubMed id 18973922)3 Vivekanandan P....Torbenson M. (2009)
- Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer. (PubMed id 18801625)3 Valladares-Ayerbes M....Anton-Aparicio L.M. (2008)
|
Search for AGR2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing AGR2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing AGR2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AGR2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for AGR2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for AGR2:

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Incremental update: 13 Oct 2009
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