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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AGR2 Gene

protein-coding   GIFtS: 61
GCID: GC07M016797

Anterior Gradient 2

(Previous name: anterior gradient 2 homolog (Xenopus laevis))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Anterior Gradient 21 2     HAG-22
AG22 3 5     PDIA172
Secreted Cement Gland Protein XAG-2 Homolog2 3     XAG-22
AG-22 3     Anterior Gradient Homolog 22
HPC82 3     Anterior Gradient Protein 2 Homolog2
Anterior Gradient 2 Homolog (Xenopus Laevis)1     Protein Disulfide Isomerase Family A, Member 172
Member 171     Secreted Cement Gland Homolog2
Protein Disulfide Isomerase Family A1     hAG-23
GOB-42     

External Ids:    HGNC: 3281   Entrez Gene: 105512   Ensembl: ENSG000001065417   OMIM: 6063585   UniProtKB: O959943   

Export aliases for AGR2 gene to outside databases

Previous GC identifers: GC07M016476 GC07M016575 GC07M016605 GC07M016719


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AGR2 Gene: 
AGR2 (anterior gradient 2) is a protein-coding gene. Diseases associated with AGR2 include dubowitz syndrome, and coccidioidomycosis. GO annotations related to this gene include dystroglycan binding and protein binding. An important paralog of this gene is TXNDC12.

UniProtKB/Swiss-Prot: AGR2_HUMAN, O95994
Function: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of
mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell
differentiation and cell growth

Gene Wiki entry for AGR2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AGR2 gene promoter:
         HFH-3   Max1   Spz1   AML1a   CUTL1   GATA-1   FOXI1   Pax-3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AGR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for AGR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.3   Ensembl cytogenetic band:  7p21.1   HGNC cytogenetic band: 7p21.3

AGR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGR2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M016797:  view genomic region     (about GC identifiers)

Start:
16,831,435 bp from pter      End:
16,873,057 bp from pter
Size:
41,623 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 16,885,921-16,898,395     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AGR2_HUMAN, O95994 (See protein sequence)
Recommended Name: Anterior gradient protein 2 homolog precursor  
Size: 175 amino acids; 19979 Da
Subunit: Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked
Subcellular location: Secreted. Endoplasmic reticulum (By similarity)
2 PDB 3D structures from and Proteopedia for AGR2:
2LNS (3D)        2LNT (3D)    

Explore the universe of human proteins at neXtProt for AGR2: NX_O95994

Explore proteomics data for AGR2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95994

  • AGR2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AGR2 Protein Expression
    REFSEQ proteins: NP_006399.1  
    ENSEMBL proteins: 
     ENSP00000391490   ENSP00000414806   ENSP00000386025   ENSP00000411969   ENSP00000388342  

    Human Recombinant Protein Products for AGR2: 
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    OriGene MassSpec for AGR2 
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    Novus Biologicals AGR2 Proteins
    Novus Biologicals AGR2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for AGR2
    Cloud-Clone Corp. Proteins for AGR2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum ISS--

    AGR2 for ontologies           About GeneDecksing



    AGR2 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for AGR2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PDI: Protein disulfide isomerases

    1 InterPro protein domain:
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry O95994

    ProtoNet protein and cluster: O95994

    UniProtKB/Swiss-Prot: AGR2_HUMAN, O95994
    Similarity: Belongs to the AGR family


    AGR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AGR2_HUMAN, O95994
    Function: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of
    mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell
    differentiation and cell growth

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002162dystroglycan binding IDA12592373
    GO:0005515protein binding IPI12592373
         
    AGR2 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Agr2):
     adipose tissue  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  reproductive system 

    AGR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for AGR2: Agr2tm1.1Lex Agr2tm1.2Erle Agr2tm1.2Lpkn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AGR2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AGR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AGR2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AGR2 

    miRNA
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    miRTarBase miRNAs that target AGR2:
    hsa-mir-197 (MIRT004183)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AGR2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AGR2
    SwitchGear 3'UTR luciferase reporter plasmidAGR2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: AGR2 (NM_006408)
    Sino Biological Human cDNA Clone for AGR2
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                         Customized lentivirus expression plasmids for stable overexpression of AGR2 

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    Search LifeMap BioReagents cell lines for AGR2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGR2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AGR2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Tyrosine Kinases / Adaptors
    Tyrosine Kinases / Adaptors
    2Adhesion
    Adhesion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for AGR2
        Tyrosine Kinases / Adaptors
    Adhesion




    AGR2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AGR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/20 Interacting proteins for AGR2 (O959942, 3 ENSP000003914904) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235068Q018603, ENSP000004050414I2D: score=1 STRING: ENSP00000405041
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    ENSG00000230336Q018603I2D: score=1 
    ENSG00000233911Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070254mucus secretion ISS--

    AGR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AGR2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AGR2

    1 Novoseek inferred chemical compound relationship for AGR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 25.6 4 16551856 (2), 9790916 (2)

    Search CenterWatch for drugs/clinical trials and news about AGR2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AGR2 gene: 
    NM_006408.3  

    Unigene Cluster for AGR2:

    Anterior gradient 2 homolog (Xenopus laevis)
    Hs.530009  [show with all ESTs]
    Unigene Representative Sequence: BM924878
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419304(uc003str.3) ENST00000450569 ENST00000401412 ENST00000412973
    ENST00000489523 ENST00000468419(uc011jxy.2) ENST00000486219 ENST00000419572

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AGR2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AGR2
    SwitchGear 3'UTR luciferase reporter plasmidAGR2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AGR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGR2
    Clone
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    OriGene clones in human, mouse for AGR2 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: AGR2 (NM_006408)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGR2
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                         Customized lentivirus expression plasmids for stable overexpression of AGR2 
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    OriGene qPCR primer pairs and template standards for AGR2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGR2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGR2

    Additional mRNA sequence: 

    AF007791.1 AF038451.1 AF038452.1 AF087879.1 AF088867.1 AF115926.1 AK124419.1 AK223067.1 
    AK296721.1 AK312942.1 AY359009.1 BC015503.1 BT007048.1 

    18 DOTS entries:

    DT.100810938  DT.75105686  DT.95279263  DT.95092567  DT.121112254  DT.121112258  DT.92007777  DT.97860996 
    DT.99960432  DT.121112240  DT.121112251  DT.91752704  DT.95253542  DT.95279319  DT.121112245  DT.95279313 
    DT.97804195  DT.121112242 

    24/663 AceView cDNA sequences (see all 663):

    BQ084526 BM790980 BM790631 BM785127 AA425142 CA310629 AA442829 BM817591 
    BM789904 AI623264 CB159944 CB144392 BM784772 BM788914 BM789541 BM790640 
    BM769028 BM856787 AA573742 AA314146 BM795553 BM794575 AA470471 CB138141 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for AGR2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                                                        -           -           -                     
    SP2:                    -                                   -           -           -                     
    SP3:                                                        -                                             
    SP4:                    -                                   -           -                                 
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for AGR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AGR2 expression in normal human tissues (normalized intensities)      AGR2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTCTAAA
    AGR2 Expression
    About this image


    AGR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/19 selected tissues (see all 19) fully expand
     
     Lung (Respiratory System)    fully expand to see all 7 entries
             Mucus-producing Cells Respiratory Bronchioles
             lung ; pneumocytes   
             Trachea   
     
     Epithelium (Uncategorized)    fully expand to see all 5 entries
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Intestine
             small intestine ; glandular cells   
             small intestine   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
             rectum   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut

    See AGR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AGR2

    SOURCE GeneReport for Unigene cluster: Hs.530009

    UniProtKB/Swiss-Prot: AGR2_HUMAN, O95994
    Tissue specificity: Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed
    weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas,
    kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell
    lines

        SABiosciences Expression via Pathway-Focused PCR Array including AGR2: 
              Lung Cancer in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for AGR2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agr21 , 5 anterior gradient 2 (Xenopus laevis)1, 5 87.81(n)1
    91.43(a)1
      12 (16.18 cM)5
    237951  NM_011783.21  NP_035913.11 
     359929075 
    chicken
    (Gallus gallus)
    Aves AGR21 anterior gradient homolog 2 (Xenopus laevis) 75.49(n)
    81.18(a)
      420596  XM_418698.3  XP_418698.1 
    lizard
    (Anolis carolinensis)
    Reptilia AGR26
    Uncharacterized protein
    80(a)
    1 ↔ 1
    6(27579559-27592728)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC537622 similar to anterior gradient 2 homolog (Xenepus laevis) 73.75(n)    BC052102.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.252772 Transcribed sequence with moderate similarity to protein more 75.07(n)    BI705255.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y57A10A.236
    F49H12.56
    Protein F49H12.5
    23(a)
    15(a)
    many ↔ many
    many ↔ many
    II(12240388-12242090)
    X(2074448-2075944)


    ENSEMBL Gene Tree for AGR2 (if available)
    TreeFam Gene Tree for AGR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AGR2 gene
    TXNDC122  AGR32  
    2 SIMAP similar genes for AGR2 using alignment to 6 protein entries:     AGR2_HUMAN (see all proteins):
    AGR3    TXNDC12

    AGR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/429 SNPs in AGR2 are shown (see all 429)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339753321,2
    C--16732250(+) TTGGC-/A/AA  
            
    AAAAA
    1 -- us2k11NA 2
    rs1882354731,2
    --16831808(+) GATTAC/TAAGGT 1 -- int10--------
    rs289450811,2
    C--16831874(-) TAGTAA/C/G/
            
    AAAGG
    1 -- int12EU CSA 95
    rs37352481,2
    C,F--16832096(+) TTAAGC/GTCGTG 1 -- int11Minor allele frequency- G:0.03EA 120
    rs37352491,2
    C,F--16832107(+) TCTACT/CTACAG 1 -- int1 ese34Minor allele frequency- C:0.10WA CSA EA 242
    rs289450801,2
    C,F--16832189(-) AGACAA/TAACCA 1 -- int17Minor allele frequency- T:0.06EU WA CSA NA 340
    rs773640301,2
    F--16832242(+) GTAAAC/TGAACC 1 -- int11Minor allele frequency- T:0.05NA 120
    rs1137239261,2
    F--16832282(+) AACACG/CCCCAA 1 -- ut311Minor allele frequency- C:0.50CSA 2
    rs80711,2
    C,F,A,H--16832382(-) AAACAA/TGTTTT 1 -- ut3110Minor allele frequency- T:0.14MN NS EA NA WA 958
    rs1484102361,2
    --16832420(+) AAACCA/GTAACC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for AGR2 (16831435 - 16873057 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AGR2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv887764CNV Gain21882294
    dgv7217n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606358    OMIM disorders: --

    18 diseases for AGR2:    About MalaCards
    dubowitz syndrome    coccidioidomycosis    cysticercosis    pancreatic ductal adenocarcinoma
    inflammatory bowel disease    pancreatitis    endometriosis    pancreatic cancer
    lung adenocarcinoma    breast cancer    adenocarcinoma    ovarian cancer
    colorectal cancer    prostate cancer    prostatitis    thyroiditis
    squamous cell carcinoma    lung cancer


    AGR2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for AGR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 27.3 8 16551856 (4), 9790916 (3)
    tumors 0 7 16551856 (4), 9790916 (1)

    Genetic Association Database (GAD): AGR2
    Human Genome Epidemiology (HuGE) Navigator: AGR2 (2 documents)

    Export disorders for AGR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AGR2 gene, integrated from 9 sources (see all 67):
    (articles sorted by number of sources associating them with AGR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines. (PubMed id 9790916)1, 2, 3, 9 Thompson D.A. and Weigel R.J. (1998)
    2. hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. (PubMed id 12592373)1, 2, 9 Fletcher G.C....Terrett J.A. (2003)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. (PubMed id 19359471)1, 2 Park S.-W.... Erle D.J. (2009)
    5. Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease. (PubMed id 16222343)1, 4 Zheng W.... Hampe J. (2006)
    6. AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer. (PubMed id 15834940)1, 2 Zhang J.-S.... Young C.Y.F. (2005)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10551 HGNC: 328 AceView: AGR2 Ensembl:ENSG00000106541 euGenes: HUgn10551
    ECgene: AGR2 H-InvDB: AGR2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AGR2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AGR2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AGR2 gene:
    Search GeneIP for patents involving AGR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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