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Aliases for AGR2 Gene

Aliases for AGR2 Gene

  • Anterior Gradient 2, Protein Disulphide Isomerase Family Member 2 3 5
  • Secreted Cement Gland Protein XAG-2 Homolog 3 4
  • HAG-2 3 4
  • AG-2 3 4
  • HPC8 3 4
  • AG2 3 4
  • Protein Disulfide Isomerase Family A, Member 17 3
  • Anterior Gradient 2 Homolog (Xenopus Laevis) 2
  • Protein Disulfide Isomerase Family A 2
  • Epididymis Secretory Protein Li 116 3
  • Secreted Cement Gland Homolog 3
  • Anterior Gradient Homolog 2 3
  • Member 17 2
  • HEL-S-116 3
  • PDIA17 3
  • GOB-4 3
  • XAG-2 3

External Ids for AGR2 Gene

Previous GeneCards Identifiers for AGR2 Gene

  • GC07M016476
  • GC07M016575
  • GC07M016605
  • GC07M016797
  • GC07M016719

Summaries for AGR2 Gene

GeneCards Summary for AGR2 Gene

AGR2 (Anterior Gradient 2, Protein Disulphide Isomerase Family Member) is a Protein Coding gene. Diseases associated with AGR2 include Pancreatic Ductal Adenocarcinoma. Among its related pathways are Adhesion and Tyrosine Kinases / Adaptors. GO annotations related to this gene include dystroglycan binding. An important paralog of this gene is TXNDC12.

UniProtKB/Swiss-Prot for AGR2 Gene

  • Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth.

Gene Wiki entry for AGR2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGR2 Gene

Genomics for AGR2 Gene

Regulatory Elements for AGR2 Gene

Enhancers for AGR2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AGR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for AGR2 Gene

Chromosome:
7
Start:
16,791,811 bp from pter
End:
16,833,433 bp from pter
Size:
41,623 bases
Orientation:
Minus strand

Genomic View for AGR2 Gene

Genes around AGR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGR2 Gene

Proteins for AGR2 Gene

  • Protein details for AGR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95994-AGR2_HUMAN
    Recommended name:
    Anterior gradient protein 2 homolog
    Protein Accession:
    O95994

    Protein attributes for AGR2 Gene

    Size:
    175 amino acids
    Molecular mass:
    19979 Da
    Quaternary structure:
    • Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for AGR2 Gene

neXtProt entry for AGR2 Gene

Proteomics data for AGR2 Gene at MOPED

Post-translational modifications for AGR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGR2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for AGR2 (AGR2)

No data available for DME Specific Peptides for AGR2 Gene

Domains & Families for AGR2 Gene

Gene Families for AGR2 Gene

Protein Domains for AGR2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O95994

UniProtKB/Swiss-Prot:

AGR2_HUMAN :
  • Belongs to the AGR family.
Family:
  • Belongs to the AGR family.
genes like me logo Genes that share domains with AGR2: view

Function for AGR2 Gene

Molecular function for AGR2 Gene

UniProtKB/Swiss-Prot Function:
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth.

Gene Ontology (GO) - Molecular Function for AGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002162 dystroglycan binding IDA 12592373
genes like me logo Genes that share ontologies with AGR2: view
genes like me logo Genes that share phenotypes with AGR2: view

Animal Models for AGR2 Gene

MGI Knock Outs for AGR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for AGR2

miRNA for AGR2 Gene

miRTarBase miRNAs that target AGR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AGR2 Gene

Localization for AGR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGR2 Gene

Secreted. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGR2 Gene COMPARTMENTS Subcellular localization image for AGR2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for AGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,ISS --
genes like me logo Genes that share ontologies with AGR2: view

Pathways & Interactions for AGR2 Gene

genes like me logo Genes that share pathways with AGR2: view

Pathways by source for AGR2 Gene

2 Cell Signaling Technology pathways for AGR2 Gene

Gene Ontology (GO) - Biological Process for AGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IMP 22184114
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IMP 25666625
GO:0060480 lung goblet cell differentiation IEA --
GO:0070254 mucus secretion IEA,ISS --
GO:0090004 positive regulation of establishment of protein localization to plasma membrane IMP 25666625
genes like me logo Genes that share ontologies with AGR2: view

No data available for SIGNOR curated interactions for AGR2 Gene

Drugs & Compounds for AGR2 Gene

(1) Drugs for AGR2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with AGR2: view

Transcripts for AGR2 Gene

Unigene Clusters for AGR2 Gene

Anterior gradient 2 homolog (Xenopus laevis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGR2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - -
SP5:
SP6: - - - -

Relevant External Links for AGR2 Gene

GeneLoc Exon Structure for
AGR2
ECgene alternative splicing isoforms for
AGR2

Expression for AGR2 Gene

mRNA expression in normal human tissues for AGR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGR2 Gene

This gene is overexpressed in Stomach (x15.9), Colon - Transverse (x13.8), and Small Intestine - Terminal Ileum (x6.3).

Protein differential expression in normal tissues from HIPED for AGR2 Gene

This gene is overexpressed in Oral epithelium (25.4) and Stomach (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AGR2 Gene



SOURCE GeneReport for Unigene cluster for AGR2 Gene Hs.530009

mRNA Expression by UniProt/SwissProt for AGR2 Gene

O95994-AGR2_HUMAN
Tissue specificity: Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines.
genes like me logo Genes that share expression patterns with AGR2: view

Protein tissue co-expression partners for AGR2 Gene

- Elite partner

Primer Products

Orthologs for AGR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for AGR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AGR2 35
  • 92.57 (n)
  • 95.43 (a)
AGR2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGR2 35
  • 90.29 (n)
  • 95.43 (a)
AGR2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agr2 35
  • 87.81 (n)
  • 91.43 (a)
Agr2 16
Agr2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AGR2 35
  • 99.81 (n)
  • 99.43 (a)
AGR2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agr2 35
  • 87.81 (n)
  • 91.43 (a)
oppossum
(Monodelphis domestica)
Mammalia AGR2 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGR2 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGR2 35
  • 75.49 (n)
  • 81.18 (a)
AGR2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGR2 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agr2 35
  • 68.7 (n)
  • 66.46 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53762 35
zebrafish
(Danio rerio)
Actinopterygii agr2 35
  • 68.89 (n)
  • 73.33 (a)
Dr.25277 35
agr2 36
  • 71 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8969 35
worm
(Caenorhabditis elegans)
Secernentea F49H12.5 36
  • 17 (a)
ManyToMany
Y57A10A.23 36
  • 26 (a)
ManyToMany
Species with no ortholog for AGR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGR2 Gene

ENSEMBL:
Gene Tree for AGR2 (if available)
TreeFam:
Gene Tree for AGR2 (if available)

Paralogs for AGR2 Gene

Paralogs for AGR2 Gene

(2) SIMAP similar genes for AGR2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with AGR2: view

Variants for AGR2 Gene

Sequence variations from dbSNP and Humsavar for AGR2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs818800 -- 16,806,897(-) TTTCC(C/T)GACAT upstream-variant-2KB
rs819005 -- 16,799,519(-) AAATT(A/C)TCTCC intron-variant
rs819006 -- 16,799,324(-) ACCAC(C/T)ACCAC intron-variant
rs819007 -- 16,798,591(-) cagag(A/T)agttg intron-variant
rs819008 -- 16,798,442(-) cttct(C/G/T)tcgcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGR2 Gene

Variant ID Type Subtype PubMed ID
dgv7217n71 CNV Gain 21882294
nsv887764 CNV Gain 21882294

Variation tolerance for AGR2 Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AGR2 Gene

Disorders for AGR2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AGR2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
- elite association - COSMIC cancer census association via MalaCards
Search AGR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AGR2

Genetic Association Database (GAD)
AGR2
Human Genome Epidemiology (HuGE) Navigator
AGR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGR2
genes like me logo Genes that share disorders with AGR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AGR2 Gene

Publications for AGR2 Gene

  1. hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines. (PMID: 9790916) Thompson D.A. … Weigel R.J. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23 67
  2. Prognostic relevance of AGR2 expression in breast cancer. (PMID: 16551856) Fritzsche F.R. … Kristiansen G. (Clin. Cancer Res. 2006) 3 23
  3. hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. (PMID: 12592373) Fletcher G.C. … Terrett J.A. (Br. J. Cancer 2003) 3 23
  4. Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition. (PMID: 25418581) Mizuuchi Y. … Oda Y. (Lab. Invest. 2015) 3
  5. Epidermal growth factor receptor (EGFR) signaling requires a specific endoplasmic reticulum thioredoxin for the post-translational control of receptor presentation to the cell surface. (PMID: 25666625) Dong A. … Lowe A.W. (J. Biol. Chem. 2015) 3

Products for AGR2 Gene

Sources for AGR2 Gene

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