Aliases for AGR2 Gene
External Ids for AGR2 Gene
Previous GeneCards Identifiers for AGR2 Gene
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017]
GeneCards Summary for AGR2 Gene
AGR2 (Anterior Gradient 2, Protein Disulphide Isomerase Family Member) is a Protein Coding gene. Diseases associated with AGR2 include Pancreatic Ductal Adenocarcinoma and Inflammatory Bowel Disease. Among its related pathways are Tyrosine Kinases / Adaptors and Adhesion. Gene Ontology (GO) annotations related to this gene include dystroglycan binding. An important paralog of this gene is AGR3.
UniProtKB/Swiss-Prot for AGR2 Gene
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113).