AGR2 Gene

Aliases
for AGR2 gene

Previous GC identifers: GC07M016476 GC07M016575 GC07M016605 GC07M016719

Summaries
for AGR2 gene

Genomic Views
for AGR2 gene

RefSeq DNA sequence:

NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  

SwitchGear Promoter luciferase reporter plasmids (see all 2): AGR2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGR2

AGR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M016797:  view genomic region     (about GC identifiers)

Proteins
for AGR2 gene

2 PDB 3D structures from and Proteopedia for AGR2:

2LNS (3D)        2LNT (3D)    

Explore the universe of human proteins at neXtProt for AGR2: NX_O95994

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: AGR2 OriGene Protein Over-expression Lysate: AGR2 OriGene Custom Protein Services for AGR2
	GenScript Custom Purified and Recombinant Proteins Services for AGR2
	Novus Biologicals AGR2 Proteins Novus Biologicals AGR2 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for AGR2
	Uscn Proteins for AGR2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of AGR2
	R&D Systems Antibodies for AGR2 (AG-2)
	Cell Signaling Technology (CST) Antibodies for AGR2
	OriGene Antibodies (see all 3): AGR2 OriGene Custom Antibody Services for AGR2
	GenScript Custom Superior Antibodies Services for AGR2
	Novus Biologicals AGR2 Antibodies
	Abcam antibodies for AGR2
	Uscn Antibodies for AGR2
	ThermoFisher Antibody for AGR2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for AGR2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for AGR2

Protein Domains /
Families
for AGR2 gene

ProtoNet protein and cluster: O95994

Function
for AGR2 gene

miRNA Products:		miRTarBase miRNAs that target AGR2: hsa-mir-197 (MIRT004183)
		OriGene 3'-UTR Clone: AGR2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AGR2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AGR2
		SwitchGear 3'UTR luciferase reporter plasmid: AGR2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AGR2 (see all 7) OriGene shRNA RFP: AGR2 OriGene siRNA: AGR2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGR2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for AGR2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AGR2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AGR2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: AGR2 (NM_006408)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for AGR2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AGR2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for AGR2
		Search LifeMap BioReagents cell lines for AGR2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGR2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Agr2)

Pathways & Interactions
for AGR2 gene

	Super-pathway	contained gene-specific pathways
1	Tyrosine Kinases / Adaptors	Tyrosine Kinases / Adaptors 1.00
2	Adhesion	Adhesion 1.00

2 Cell Signaling Technology (CST) Pathways for AGR2

	Tyrosine Kinases / Adaptors
	Adhesion

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

Drugs & Compounds
for AGR2 gene

Transcripts
for AGR2 gene

Expression
for AGR2 gene

AGR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTTCTAAA

5 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	LungRespiratory BronchiolesMucus-producing Cells			Lung
	Gut TubeHindgutHindgut Endoderm Cells			Endoderm
	Gut TubeMidgutMidgut Endoderm Cells			Endoderm
	Gut TubeHindgut			Gut Tube
	Gut TubeMidgut			Gut Tube
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Alveolar type II cells (Derivation of mature...)			Lung

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AGR2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AGR2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AGR2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AGR2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGR2

Orthologs
for AGR2 gene

Paralogs
for AGR2 gene

Paralogs for AGR2 gene

TXNDC12²  AGR3²  

2 SIMAP similar genes for AGR2 using alignment to 6 protein entries:     AGR2_HUMAN (see all proteins):

AGR3    TXNDC12

AGR2 for paralogs           About GeneDecksing

Genomic Variants
for AGR2 gene

10/359 NCBI SNPs in AGR2 are shown (see all 359)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1882354731,2		--	16831808(+)	GATTAC/TAAGGT	1	--	int1		0	--	--	--	--
rs289450811,2	C	--	16831874(-)	TAGTAA/C/GAAAGG	1	--	int1		2		EU CSA	95
rs37352481,2	C,F,	--	16832096(+)	TTAAGC/GTCGTG	1	--	int1		1		EA	120
rs37352491,2	C,F,	--	16832107(+)	TCTACT/CTACAG	1	--	int1 ese3		4		WA CSA EA	242
rs289450801,2	C,F,	--	16832189(-)	AGACAA/TAACCA	1	--	int1		7		EU WA CSA NA	340
rs773640301,2	F,	--	16832242(+)	GTAAAC/TGAACC	1	--	int1		1		NA	120
rs1137239261,2		--	16832282(+)	AACACG/CCCCAA	1	--	ut31		1		CSA	2
rs80711,2	C,F,A,H,	--	16832382(-)	AAACAA/TGTTTT	1	--	ut31		10		MN NS EA NA WA	958
rs1484102361,2		--	16832420(+)	AAACCA/GTAACC	1	--	ut31		0	--	--	--	--
rs1425019771,2	C,	--	16832619(+)	ACCATC/TGTGCG	1	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for AGR2 (16831435 - 16873057 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for AGR2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AGR2

DNA2.0 Custom Variant and Variant Library Synthesis for AGR2

Disorders / Diseases
for AGR2 gene

16 diseases for AGR2

2 Novoseek disease relationships for AGR2 gene    About this table

Publications
for AGR2 gene

PubMed articles for AGR2 gene, integrated from 9 sources (see all 59): (articles sorted by number of sources associating them with AGR2)

Utopia: connect your pdf to the dynamic world of online information

1. hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines. (PubMed id 9790916)^{1, 2, 3, 9} Thompson D.A. and Weigel R.J. (1998)
2. hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. (PubMed id 12592373)^{1, 2, 9} Fletcher G.C....Terrett J.A. (2003)
3. The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. (PubMed id 19359471)^{1, 2} Park S.-W.... Erle D.J. (2009)
4. Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease. (PubMed id 16222343)^{1, 4} Zheng W.... Hampe J. (2006)
5. AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer. (PubMed id 15834940)^{1, 2} Zhang J.-S.... Young C.Y.F. (2005)
6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
8. The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
10. Prognostic relevance of AGR2 expression in breast cancer. (PubMed id 16551856)^{1, 9} Fritzsche F.R....Kristiansen G. (2006)

External Searches for AGR2 gene

Genome Databases showing AGR2 gene

Other Databases showing AGR2 gene

Specialized Databases showing AGR2 gene

Products
for AGR2 gene