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AGR2 Gene

protein-coding   GIFtS: 60
GCID: GC07M016831

Anterior Gradient 2

(Previous name: anterior gradient 2 homolog (Xenopus laevis))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Anterior Gradient 21 2     HEL-S-1162
AG22 3 5     PDIA172
Secreted Cement Gland Protein XAG-2 Homolog2 3     XAG-22
AG-22 3     Anterior Gradient Homolog 22
HPC82 3     Anterior Gradient Protein 2 Homolog2
Anterior Gradient 2 Homolog (Xenopus Laevis)1     Epididymis Secretory Protein Li 1162
Member 171     Protein Disulfide Isomerase Family A, Member 172
Protein Disulfide Isomerase Family A1     Secreted Cement Gland Homolog2
GOB-42     hAG-23
HAG-22     

External Ids:    HGNC: 3281   Entrez Gene: 105512   Ensembl: ENSG000001065417   OMIM: 6063585   UniProtKB: O959943   

Export aliases for AGR2 gene to outside databases

Previous GC identifers: GC07M016476 GC07M016575 GC07M016605 GC07M016797 GC07M016719


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AGR2 Gene:
AGR2 (anterior gradient 2) is a protein-coding gene. GO annotations related to this gene include dystroglycan binding. An important paralog of this gene is TXNDC12.

UniProtKB/Swiss-Prot: AGR2_HUMAN, O95994
Function: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of
mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell
differentiation and cell growth

Gene Wiki entry for AGR2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AGR2 gene promoter:
         HFH-3   Max1   Spz1   AML1a   CUTL1   GATA-1   FOXI1   Pax-3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AGR2 promoter sequence
   Search Chromatin IP Primers for AGR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.3   Ensembl cytogenetic band:  7p21.1   HGNC cytogenetic band: 7p21.3

AGR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGR2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M016831:  view genomic region     (about GC identifiers)

Start:
16,831,435 bp from pter      End:
16,873,057 bp from pter
Size:
41,623 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 16,885,921-16,898,395     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AGR2_HUMAN, O95994 (See protein sequence)
Recommended Name: Anterior gradient protein 2 homolog precursor  
Size: 175 amino acids; 19979 Da
Subunit: Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked
2 PDB 3D structures from and Proteopedia for AGR2:
2LNS (3D)        2LNT (3D)    

Explore the universe of human proteins at neXtProt for AGR2: NX_O95994

Explore proteomics data for AGR2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AGR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006399.1  
    ENSEMBL proteins: 
     ENSP00000391490   ENSP00000414806   ENSP00000386025   ENSP00000411969   ENSP00000388342  

    AGR2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for AGR2

     
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    antibodies-online proteins for AGR2 (34 products) 

     
    antibodies-online peptides for AGR2

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    antibodies-online kits for AGR2 (17 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PDI: Protein disulfide isomerases

    1 InterPro protein domain:
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry O95994

    ProtoNet protein and cluster: O95994

    UniProtKB/Swiss-Prot: AGR2_HUMAN, O95994
    Similarity: Belongs to the AGR family


    Find genes that share domains with AGR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AGR2_HUMAN, O95994
    Function: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of
    mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell
    differentiation and cell growth

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002162dystroglycan binding IDA12592373
    GO:0005515protein binding IPI12592373
         
    Find genes that share ontologies with AGR2           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Agr2):
     adipose tissue  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  reproductive system 

    Find genes that share phenotypes with AGR2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for AGR2: Agr2tm1.1Lex Agr2tm1.2Erle Agr2tm1.2Lpkn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AGR2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AGR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AGR2

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    hsa-mir-335-5p (MIRT018401), hsa-mir-197-3p (MIRT004183)

    Block miRNA regulation of human, mouse, rat AGR2 using miScript Target Protectors
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    Addgene plasmids for AGR2 

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    eBioscience FlowRNA Probe Sets ( VA1-13849) for AGR2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AGR2_HUMAN, O95994: Secreted. Endoplasmic reticulum (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum4
    mitochondrion2
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum ISS--

    Find genes that share ontologies with AGR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AGR2 About    
    See pathways by source

    SuperPathContained pathways About
    1Tyrosine Kinases / Adaptors
    Tyrosine Kinases / Adaptors
    2Adhesion
    Adhesion


    Find genes that share SuperPaths with AGR2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for AGR2
        Tyrosine Kinases / Adaptors
    Adhesion



        Pathway & Disease-focused RT2 Profiler PCR Array including AGR2: 
              Lung Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AGR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for AGR2 (O959942, 3 ENSP000003914904) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235068Q018603, ENSP000004050414I2D: score=1 STRING: ENSP00000405041
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    ENSG00000230336Q018603I2D: score=1 
    ENSG00000233911Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0060480lung goblet cell differentiation IEA--
    GO:0070254mucus secretion ISS--

    Find genes that share ontologies with AGR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AGR2

    1 Novoseek inferred chemical compound relationship for AGR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 25.6 4 16551856 (2), 9790916 (2)



    Find genes that share compounds with AGR2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AGR2 gene: 
    NM_006408.3  

    Unigene Cluster for AGR2:

    Anterior gradient 2 homolog (Xenopus laevis)
    Hs.530009  [show with all ESTs]
    Unigene Representative Sequence: BM924878
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419304(uc003str.3) ENST00000450569 ENST00000401412 ENST00000412973
    ENST00000489523 ENST00000468419(uc011jxy.2) ENST00000486219 ENST00000419572

    miRNA
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13849) for AGR2 

    Additional mRNA sequence: 

    AF007791.1 AF038451.1 AF038452.1 AF087879.1 AF088867.1 AF115926.1 AK124419.1 AK223067.1 
    AK296721.1 AK312942.1 AY359009.1 BC015503.1 BT007048.1 

    18 DOTS entries:

    DT.100810938  DT.75105686  DT.95279263  DT.95092567  DT.121112254  DT.121112258  DT.92007777  DT.97860996 
    DT.99960432  DT.121112240  DT.121112251  DT.91752704  DT.95253542  DT.95279319  DT.121112245  DT.95279313 
    DT.97804195  DT.121112242 

    Selected AceView cDNA sequences (see all 663):

    CB138141 BM834655 AI783818 BM790618 BQ084303 BM784772 BM768970 BM791366 
    AI249798 BM769244 BM795553 BQ083559 BM765629 AA558986 AA315629 AA639696 
    BM852529 BU686588 BM839242 BQ083902 BM791009 AW152169 BU688109 BM790631 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AGR2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                                                        -           -           -                     
    SP2:                    -                                   -           -           -                     
    SP3:                                                        -                                             
    SP4:                    -                                   -           -                                 
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for AGR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AGR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTCTAAA
    AGR2 Expression
    About this image


    AGR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Mucus-producing Cells Respiratory Bronchioles
             Alveolar type II cells
     
     Epithelial Cells
             Mucus-producing Cells Respiratory Bronchioles
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
    AGR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AGR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530009

    UniProtKB/Swiss-Prot: AGR2_HUMAN, O95994
    Tissue specificity: Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed
    weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas,
    kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell
    lines

        Pathway & Disease-focused RT2 Profiler PCR Array including AGR2: 
              Lung Cancer in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AGR2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agr21 , 5 anterior gradient 2 (Xenopus laevis)5
    anterior gradient 21
    87.81(n)1
    91.43(a)1
      12 (16.18 cM)5
    237951  NM_011783.21  NP_035913.11 
     359929075 
    chicken
    (Gallus gallus)
    Aves AGR21 anterior gradient homolog 2 (Xenopus laevis) 75.49(n)
    81.18(a)
      420596  XM_004939333.1  XP_004939390.1 
    lizard
    (Anolis carolinensis)
    Reptilia AGR26
    anterior gradient 2
    79(a)
    1 ↔ 1
    6(27579559-27592728)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC537622 similar to anterior gradient 2 homolog (Xenepus laevis) 73.75(n)    BC052102.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.252772 Transcribed sequence with moderate similarity to protein more 75.07(n)    BI705255.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y57A10A.236
    F49H12.56
    Protein F49H12.5 (F49H12.5) mRNA, complete cds
    26(a)
    17(a)
    many ↔ many
    many ↔ many
    II(12240388-12242090) WBGene00013263
    X(2074448-2075944) WBGene00018656


    ENSEMBL Gene Tree for AGR2 (if available)
    TreeFam Gene Tree for AGR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AGR2 gene
    TXNDC122  AGR32  
    2 SIMAP similar genes for AGR2 using alignment to 6 protein entries:     AGR2_HUMAN (see all proteins):
    AGR3    TXNDC12

    Find genes that share paralogs with AGR2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AGR2 (see all 429)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339753321,2
    C--16732250(+) TTGGC-/A/AA  
            
    AAAAA
    1 -- us2k11NA 2
    rs1882354731,2
    --16831808(+) GATTAC/TAAGGT 1 -- int10--------
    rs289450811,2
    C--16831874(-) TAGTAA/C/G/
            
    AAAGG
    1 -- int12EU CSA 95
    rs37352481,2
    C,F--16832096(+) TTAAGC/GTCGTG 1 -- int11Minor allele frequency- G:0.03EA 120
    rs37352491,2
    C,F--16832107(+) TCTACT/CTACAG 1 -- int1 ese34Minor allele frequency- C:0.10WA CSA EA 242
    rs289450801,2
    C,F--16832189(-) AGACAA/TAACCA 1 -- int17Minor allele frequency- T:0.06EU WA CSA NA 340
    rs773640301,2
    F--16832242(+) GTAAAC/TGAACC 1 -- int11Minor allele frequency- T:0.05NA 120
    rs1137239261,2
    F--16832282(+) AACACG/CCCCAA 1 -- ut311Minor allele frequency- C:0.50CSA 2
    rs80711,2
    C,F,A,H--16832382(-) AAACAA/TGTTTT 1 -- ut3110Minor allele frequency- T:0.14MN NS EA NA WA 958
    rs1484102361,2
    --16832420(+) AAACCA/GTAACC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for AGR2 (16831435 - 16873057 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AGR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv887764CNV Gain21882294
    dgv7217n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AGR2
    DNA2.0 Custom Variant and Variant Library Synthesis for AGR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606358    OMIM disorders: --


    Find genes that share disorders with AGR2           About GenesLikeMe

    2 Novoseek inferred disease relationships for AGR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 27.3 8 16551856 (4), 9790916 (3)
    tumors 0 7 16551856 (4), 9790916 (1)

    Genetic Association Database (GAD): AGR2
    Human Genome Epidemiology (HuGE) Navigator: AGR2 (2 documents)

    Export disorders for AGR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AGR2 gene, integrated from 10 sources (see all 72):
    (articles sorted by number of sources associating them with AGR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines. (PubMed id 9790916)1, 2, 3, 9 Thompson D.A. and Weigel R.J. (Biochem. Biophys. Res. Commun. 1998)
    2. hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. (PubMed id 12592373)1, 2, 9 Fletcher G.C....Terrett J.A. (Br. J. Cancer 2003)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. (PubMed id 19359471)1, 2 Park S.-W.... Erle D.J. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    5. Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease. (PubMed id 16222343)1, 4 Zheng W.... Hampe J. (Genes Immun. 2006)
    6. AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer. (PubMed id 15834940)1, 2 Zhang J.-S.... Young C.Y.F. (Genes Chromosomes Cancer 2005)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10551 HGNC: 328 AceView: AGR2 Ensembl:ENSG00000106541 euGenes: HUgn10551
    ECgene: AGR2 H-InvDB: AGR2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AGR2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AGR2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AGR2 gene:
    Search GeneIP for patents involving AGR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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