Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AGPS Gene

Aliases for AGPS Gene

  • Alkylglycerone Phosphate Synthase 2 3
  • Alkylglycerone-Phosphate Synthase 3 4
  • Aging-Associated Gene 5 Protein 3 4
  • Alkyl-DHAP Synthase 3 4
  • EC 2.5.1.26 4 63
  • ADHAPS 3 6
  • Alkyldihydroxyacetonephosphate Synthase, Peroxisomal 3
  • Aging-Associated Protein 5 3
  • ALDHPSY 3
  • ADAP-S 3
  • ADAS 3
  • ADPS 3

External Ids for AGPS Gene

Previous GeneCards Identifiers for AGPS Gene

  • GC02P176320
  • GC02P176928
  • GC02P178221
  • GC02P178460
  • GC02P178083
  • GC02P177965
  • GC02P170128

Summaries for AGPS Gene

Entrez Gene Summary for AGPS Gene

  • This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGPS Gene

AGPS (Alkylglycerone Phosphate Synthase) is a Protein Coding gene. Diseases associated with AGPS include rhizomelic chondrodysplasia punctata, type 3 and rhizomelic chondrodysplasia punctata. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include FAD binding and alkylglycerone-phosphate synthase activity. An important paralog of this gene is LDHD.

UniProtKB/Swiss-Prot for AGPS Gene

  • Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGPS Gene

Genomics for AGPS Gene

Regulatory Elements for AGPS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AGPS Gene

Start:
177,392,644 bp from pter
End:
177,543,836 bp from pter
Size:
151,193 bases
Orientation:
Plus strand

Genomic View for AGPS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGPS Gene

Proteins for AGPS Gene

  • Protein details for AGPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00116-ADAS_HUMAN
    Recommended name:
    Alkyldihydroxyacetonephosphate synthase, peroxisomal
    Protein Accession:
    O00116
    Secondary Accessions:
    • A5D8U9
    • Q2TU35

    Protein attributes for AGPS Gene

    Size:
    658 amino acids
    Molecular mass:
    72912 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Homodimer.

neXtProt entry for AGPS Gene

Proteomics data for AGPS Gene at MOPED

Selected DME Specific Peptides for AGPS Gene

Post-translational modifications for AGPS Gene

  • Ubiquitination at Lys92, Lys102, Lys108, Lys456, and Lys490
  • Modification sites at PhosphoSitePlus

Other Protein References for AGPS Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for AGPS Gene

Suggested Antigen Peptide Sequences for AGPS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00116

UniProtKB/Swiss-Prot:

ADAS_HUMAN :
  • O00116
Domain:
  • Contains 1 FAD-binding PCMH-type domain.
Family:
  • Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
genes like me logo Genes that share domains with AGPS: view

No data available for Gene Families for AGPS Gene

Function for AGPS Gene

Molecular function for AGPS Gene

UniProtKB/Swiss-Prot CatalyticActivity: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion
UniProtKB/Swiss-Prot Function: Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.

Enzyme Numbers (IUBMB) for AGPS Gene

Gene Ontology (GO) - Molecular Function for AGPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0005515 protein binding IPI 25416956
GO:0008609 alkylglycerone-phosphate synthase activity IDA 10415121
GO:0008762 UDP-N-acetylmuramate dehydrogenase activity IEA --
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with AGPS: view
genes like me logo Genes that share phenotypes with AGPS: view

Animal Model Products

CRISPR Products

miRNA for AGPS Gene

miRTarBase miRNAs that target AGPS

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGPS

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for AGPS Gene

Localization for AGPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGPS Gene

Peroxisome membrane. Note=Localized to the inner aspect of the peroxisomal membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGPS Gene COMPARTMENTS Subcellular localization image for AGPS gene
Compartment Confidence
peroxisome 5
plasma membrane 3
cytosol 2
mitochondrion 2
extracellular 1
golgi apparatus 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for AGPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IDA 20833797
GO:0005777 peroxisome IDA 10415121
GO:0005778 peroxisomal membrane IDA 21525035
GO:0005782 peroxisomal matrix TAS --
genes like me logo Genes that share ontologies with AGPS: view

Pathways for AGPS Gene

genes like me logo Genes that share pathways with AGPS: view

Pathways by source for AGPS Gene

UniProtKB/Swiss-Prot O00116-ADAS_HUMAN

  • Pathway: Glycerolipid metabolism; ether lipid biosynthesis

Gene Ontology (GO) - Biological Process for AGPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008610 lipid biosynthetic process IDA 9553082
GO:0008611 ether lipid biosynthetic process TAS --
GO:0044255 cellular lipid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with AGPS: view

Compounds for AGPS Gene

(10) HMDB Compounds for AGPS Gene

Compound Synonyms Cas Number PubMed IDs
1-Hexadecanol
  • 1-Cetanol
36653-82-4
1-Undecanol
  • 1-Hendecanol
112-42-5
Arachidyl alcohol
  • n-1-Eicosanol
629-96-9
Decyl alcohol
  • Royaltac-85
112-30-1
DHAP(18:0)
  • 1-Octadecanoyl-glycerone-3-phosphate
Not Available

(9) Novoseek inferred chemical compound relationships for AGPS Gene

Compound -log(P) Hits PubMed IDs
arabinogalactan 94 21
dhap 66 3
hydroxyproline 27.3 2
polysaccharide 15.3 2
threonine 8.27 2
genes like me logo Genes that share compounds with AGPS: view

Transcripts for AGPS Gene

Unigene Clusters for AGPS Gene

Alkylglycerone phosphate synthase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGPS

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for AGPS
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGPS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
SP1: -
SP2: - - - - - - - - - - - - - - - - -
SP3:

Relevant External Links for AGPS Gene

GeneLoc Exon Structure for
AGPS
ECgene alternative splicing isoforms for
AGPS

Expression for AGPS Gene

mRNA expression in normal human tissues for AGPS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for AGPS Gene

SOURCE GeneReport for Unigene cluster for AGPS Gene Hs.516543

genes like me logo Genes that share expressions with AGPS: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AGPS Gene

Orthologs for AGPS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AGPS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGPS 35
  • 99.65 (n)
  • 99.85 (a)
AGPS 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AGPS 35
  • 94.99 (n)
  • 97.28 (a)
AGPS 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGPS 35
  • 93.53 (n)
  • 94.01 (a)
AGPS 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agps 35
  • 90.96 (n)
  • 93.1 (a)
Agps 16
Agps 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGPS 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGPS 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agps 35
  • 91.49 (n)
  • 92.3 (a)
chicken
(Gallus gallus)
Aves AGPS 35
  • 80.5 (n)
  • 82.52 (a)
AGPS 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGPS 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agps 35
  • 76.6 (n)
  • 81.18 (a)
zebrafish
(Danio rerio)
Actinopterygii agps 35
  • 70.04 (n)
  • 75.65 (a)
agps 36
  • 74 (a)
OneToOne
wufd16e06 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004358 35
  • 53.73 (n)
  • 53.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10253 35
  • 55.89 (n)
  • 55.24 (a)
CG10253 36
  • 50 (a)
OneToOne
CG10253 37
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea ads-1 35
  • 57.13 (n)
  • 54.21 (a)
ads-1 36
  • 51 (a)
OneToOne
ads-1 37
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DLD1 36
  • 17 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13977 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToOne
Species with no ortholog for AGPS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGPS Gene

ENSEMBL:
Gene Tree for AGPS (if available)
TreeFam:
Gene Tree for AGPS (if available)

Paralogs for AGPS Gene

Paralogs for AGPS Gene

genes like me logo Genes that share paralogs with AGPS: view

Variants for AGPS Gene

Sequence variations from dbSNP and Humsavar for AGPS Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs8941 -- 177,541,753(+) CTAGG(C/T)TTCAT utr-variant-3-prime
rs752320 -- 177,504,634(+) TGTAG(C/T)GTTTA intron-variant
rs935426 -- 177,504,705(+) TGAGG(C/T)GATAA intron-variant
rs952745 -- 177,441,624(+) TGAAC(C/T)TTACA intron-variant
rs952746 -- 177,441,856(+) TCTAT(A/G)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGPS Gene

Variant ID Type Subtype PubMed ID
esv2433824 CNV Deletion 19546169
esv2084314 CNV Deletion 18987734
esv2721181 CNV Deletion 23290073
esv8338 CNV Loss 19470904
esv2665427 CNV Deletion 23128226
esv1528872 CNV Insertion 17803354
nsv507053 CNV Insertion 20534489
esv267553 CNV Insertion 20981092
esv272459 CNV Insertion 20981092
esv1690590 CNV Insertion 17803354
esv2660495 CNV Deletion 23128226

Relevant External Links for AGPS Gene

HapMap Linkage Disequilibrium report
AGPS
Human Gene Mutation Database (HGMD)
AGPS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGPS Gene

Disorders for AGPS Gene

(1) OMIM Diseases for AGPS Gene (603051)

UniProtKB/Swiss-Prot

ADAS_HUMAN
  • Rhizomelic chondrodysplasia punctata 3 (RCDP3) [MIM:600121]: A disease characterized by rhizomelic shortening of femur and humerus, vertebral disorders, cataract, cutaneous lesions and severe mental retardation. {ECO:0000269 PubMed:11152660, ECO:0000269 PubMed:21990100, ECO:0000269 PubMed:9553082}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) Novoseek inferred disease relationships for AGPS Gene

Disease -log(P) Hits PubMed IDs
chondrodysplasia punctata rhizomelic 86.1 1
peroxisomal disorders 68.4 2
zellweger syndrome 68.3 1

Relevant External Links for AGPS

Genetic Association Database (GAD)
AGPS
Human Genome Epidemiology (HuGE) Navigator
AGPS
genes like me logo Genes that share disorders with AGPS: view

Publications for AGPS Gene

  1. Nucleotide sequence of human alkyl-dihydroxyacetonephosphate synthase cDNA reveals the presence of a peroxisomal targeting signal 2. (PMID: 9187299) de Vet E.C.J.M. … van den Bosch H. (Biochim. Biophys. Acta 1997) 2 3 4
  2. Alkyl-dihydroxyacetonephosphate synthase. Fate in peroxisome biogenesis disorders and identification of the point mutation underlying a single enzyme deficiency. (PMID: 9553082) de Vet E.C.J.M. … van den Bosch H. (J. Biol. Chem. 1998) 2 3 4
  3. Immunological localization and tissue distribution of alkyldihydroxyacetonephosphate synthase and deficiency of the enzyme in peroxisomal disorders. (PMID: 9266692) de Vet E.C. … van den Bosch H. (Eur. J. Biochem. 1997) 3 23
  4. Impaired membrane traffic in defective ether lipid biosynthesis. (PMID: 11152660) Thai T.P. … Just W.W. (Hum. Mol. Genet. 2001) 3 4
  5. Immunological analyses of alkyl-dihydroxyacetone-phosphate synthase in human peroxisomal disorders. (PMID: 10384985) Biermann J. … van den Bosch H. (Eur. J. Cell Biol. 1999) 3 23

Products for AGPS Gene

Sources for AGPS Gene

Back to Top

Content