Aliases for AGPS Gene
External Ids for AGPS Gene
Previous GeneCards Identifiers for AGPS Gene
This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for AGPS Gene
AGPS (Alkylglycerone Phosphate Synthase) is a Protein Coding gene. Diseases associated with AGPS include Chondrodysplasia Punctata, Rhizomelic, Type 3 and Rhizomelic Chondrodysplasia Punctata. Among its related pathways are Metabolism and Peroxisome. GO annotations related to this gene include oxidoreductase activity and FAD binding. An important paralog of this gene is LDHD.
UniProtKB/Swiss-Prot for AGPS Gene
Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.