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Aliases for AGPAT9 Gene

Aliases for AGPAT9 Gene

  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 9 2 3
  • GPAT3 3 4 6
  • MAG1 3 4 6
  • 1-Acyl-Sn-Glycerol-3-Phosphate O-Acyltransferase 10 3 4
  • 1-Acyl-Sn-Glycerol-3-Phosphate O-Acyltransferase 9 3 4
  • Acyl-CoA:Glycerol-3-Phosphate Acyltransferase 3 3 4
  • Lung Cancer Metastasis-Associated Protein 1 3 4
  • Lysophosphatidic Acid Acyltransferase Theta 3 4
  • 1-AGP Acyltransferase 9 3 4
  • LPAAT-Theta 3 4
  • EC 2.3.1.15 4 63
  • 1-AGPAT 9 3 4
  • AGPAT 10 3 4
  • GPAT-3 3 4
  • HGPAT3 3 4
  • MAG-1 3 4
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 9 (Lysophosphatidic Acid Acyltransferase, Theta) 2
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 8 3
  • Lysophosphatidic Acid Acyltransferase, Theta 3
  • Glycerol-3-Phosphate Acyltransferase 3 3
  • Lysophosphatidic Acid Acyltransferase 2
  • Endoplasmic Reticulum Associated GPAT 3
  • EC 2.3.1.51 4
  • HMFN0839 3
  • AGPAT8 3
  • Theta 2

External Ids for AGPAT9 Gene

Previous GeneCards Identifiers for AGPAT9 Gene

  • GC04P084678
  • GC04P084457
  • GC04P080200

Summaries for AGPAT9 Gene

Entrez Gene Summary for AGPAT9 Gene

  • This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]

GeneCards Summary for AGPAT9 Gene

AGPAT9 (1-Acylglycerol-3-Phosphate O-Acyltransferase 9) is a Protein Coding gene. Diseases associated with AGPAT9 include lung cancer. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include 1-acylglycerol-3-phosphate O-acyltransferase activity and glycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT6.

UniProtKB/Swiss-Prot for AGPAT9 Gene

  • May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid, or PA).

Gene Wiki entry for AGPAT9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGPAT9 Gene

Genomics for AGPAT9 Gene

Regulatory Elements for AGPAT9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AGPAT9 Gene

Start:
83,535,733 bp from pter
End:
83,605,875 bp from pter
Size:
70,143 bases
Orientation:
Plus strand

Genomic View for AGPAT9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGPAT9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGPAT9 Gene

Proteins for AGPAT9 Gene

  • Protein details for AGPAT9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53EU6-GPAT3_HUMAN
    Recommended name:
    Glycerol-3-phosphate acyltransferase 3
    Protein Accession:
    Q53EU6
    Secondary Accessions:
    • Q68CJ4
    • Q6GPI6
    • Q96NA3

    Protein attributes for AGPAT9 Gene

    Size:
    434 amino acids
    Molecular mass:
    48705 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AGPAT9 Gene

Proteomics data for AGPAT9 Gene at MOPED

Post-translational modifications for AGPAT9 Gene

  • Ubiquitination at Lys64
  • Modification sites at PhosphoSitePlus

Other Protein References for AGPAT9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for AGPAT9 Gene

Gene Families for AGPAT9 Gene

HGNC:
  • AGPAT :1-acylglycerol-3-phosphate O-acyltransferases

Protein Domains for AGPAT9 Gene

Suggested Antigen Peptide Sequences for AGPAT9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53EU6

UniProtKB/Swiss-Prot:

GPAT3_HUMAN :
  • Q53EU6
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with AGPAT9: view

Function for AGPAT9 Gene

Molecular function for AGPAT9 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethylmaleimide (NEM).
UniProtKB/Swiss-Prot Function:
May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid, or PA).

Enzyme Numbers (IUBMB) for AGPAT9 Gene

Gene Ontology (GO) - Molecular Function for AGPAT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity IEA --
GO:0004366 glycerol-3-phosphate O-acyltransferase activity IDA 17170135
GO:0016746 transferase activity, transferring acyl groups --
genes like me logo Genes that share ontologies with AGPAT9: view

Phenotypes for AGPAT9 Gene

GenomeRNAi human phenotypes for AGPAT9:
genes like me logo Genes that share phenotypes with AGPAT9: view

Animal Model Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AGPAT9 Gene

Localization for AGPAT9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGPAT9 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGPAT9 Gene COMPARTMENTS Subcellular localization image for AGPAT9 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for AGPAT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 17170135
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AGPAT9: view

Pathways for AGPAT9 Gene

genes like me logo Genes that share pathways with AGPAT9: view

UniProtKB/Swiss-Prot Q53EU6-GPAT3_HUMAN

  • Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis
  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3

Gene Ontology (GO) - Biological Process for AGPAT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0008152 metabolic process --
GO:0016024 CDP-diacylglycerol biosynthetic process IEA --
GO:0019432 triglyceride biosynthetic process TAS --
genes like me logo Genes that share ontologies with AGPAT9: view

Compounds for AGPAT9 Gene

(331) HMDB Compounds for AGPAT9 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with AGPAT9: view

Transcripts for AGPAT9 Gene

Unigene Clusters for AGPAT9 Gene

1-acylglycerol-3-phosphate O-acyltransferase 9:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGPAT9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - -
SP2:
SP3: - -
SP4: - - -

Relevant External Links for AGPAT9 Gene

GeneLoc Exon Structure for
AGPAT9
ECgene alternative splicing isoforms for
AGPAT9

Expression for AGPAT9 Gene

mRNA expression in normal human tissues for AGPAT9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGPAT9 Gene

This gene is overexpressed in Whole Blood (6.5) and Muscle - Skeletal (5.5).

Protein differential expression in normal tissues for AGPAT9 Gene

This gene is overexpressed in Breast (29.2), Cervix (22.1), and Adrenal (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGPAT9 Gene

SOURCE GeneReport for Unigene cluster for AGPAT9 Gene Hs.99196

mRNA Expression by UniProt/SwissProt for AGPAT9 Gene

Q53EU6-GPAT3_HUMAN
Tissue specificity: Widely expressed. Expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid, prostate, thymus and placenta. Also expressed lung and adipose tissue.
genes like me logo Genes that share expressions with AGPAT9: view

In Situ Assay Products

No data available for Expression partners for AGPAT9 Gene

Orthologs for AGPAT9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AGPAT9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AGPAT9 35
  • 90.76 (n)
  • 91.92 (a)
AGPAT9 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGPAT9 35
  • 94.07 (n)
  • 97.92 (a)
AGPAT9 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agpat9 35
  • 88.27 (n)
  • 94.68 (a)
Agpat9 16
Agpat9 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AGPAT9 35
  • 99.69 (n)
  • 99.77 (a)
AGPAT9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agpat9 35
  • 87.33 (n)
  • 92.4 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia AGPAT9 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGPAT9 35
  • 76.02 (n)
  • 80.05 (a)
AGPAT9 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGPAT9 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485787 35
  • 74 (n)
  • 78.69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11126 35
zebrafish
(Danio rerio)
Actinopterygii agpat9 36
  • 69 (a)
OneToMany
agpat9l 36
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG15450 36
  • 38 (a)
ManyToMany
CG3209 36
  • 44 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acl-4 36
  • 35 (a)
ManyToMany
acl-5 36
  • 37 (a)
ManyToMany
M79.2 36
  • 25 (a)
ManyToMany
corn
(Zea mays)
Liliopsida Zm.35 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1550 36
  • 43 (a)
OneToMany
Species with no ortholog for AGPAT9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGPAT9 Gene

ENSEMBL:
Gene Tree for AGPAT9 (if available)
TreeFam:
Gene Tree for AGPAT9 (if available)

Paralogs for AGPAT9 Gene

Paralogs for AGPAT9 Gene

Selected SIMAP similar genes for AGPAT9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AGPAT9: view

Variants for AGPAT9 Gene

Sequence variations from dbSNP and Humsavar for AGPAT9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs483676 -- 83,564,463(+) ggagg(A/C)tgagg intron-variant
rs501368 -- 83,547,538(+) tgagc(C/T)actgc intron-variant
rs501522 -- 83,547,479(+) GATCT(C/T)CTGAC intron-variant
rs502384 -- 83,547,397(-) cgggc(A/G)cctgt intron-variant
rs536293 -- 83,541,584(-) TAGCT(C/T)TAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGPAT9 Gene

Variant ID Type Subtype PubMed ID
nsv829994 CNV Loss 17160897
nsv879512 CNV Gain 21882294
nsv829995 CNV Loss 17160897
esv2727904 CNV Deletion 23290073
esv2676861 CNV Deletion 23128226

Relevant External Links for AGPAT9 Gene

HapMap Linkage Disequilibrium report
AGPAT9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGPAT9 Gene

Disorders for AGPAT9 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for AGPAT9 Gene in MalaCards »

(1) Diseases for AGPAT9 Gene including...

(1) University of Copenhagen DISEASES for AGPAT9 Gene

Relevant External Links for AGPAT9

Genetic Association Database (GAD)
AGPAT9
genes like me logo Genes that share disorders with AGPAT9: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for AGPAT9 Gene

Publications for AGPAT9 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S. … Nakagawara A. (Oncogene 2004) 3 4
  4. Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway. (PMID: 17002884) Tang W. … Yu L. (J. Biochem. Mol. Biol. 2006) 3 4
  5. Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis. (PMID: 17170135) Cao J. … Gimeno R.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4

Products for AGPAT9 Gene

Sources for AGPAT9 Gene

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