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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AGPAT9 Gene

protein-coding   GIFtS: 58
GCID: GC04P084457

1-Acylglycerol-3-Phosphate O-Acyltransferase 9

(Previous names: 1-acylglycerol-3-phosphate O-acyltransferase 9 (lysophosphatidic...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
1-Acylglycerol-3-Phosphate O-Acyltransferase 91 2 3     hGPAT32 3
MAG12 3 5     EC 2.3.1.153 8
Acyl-CoA:Glycerol-3-Phosphate Acyltransferase 32 3     AGPAT82 5
Lung Cancer Metastasis-Associated Protein 12 3     1-Acylglycerol-3-Phosphate O-Acyltransferase 9 (Lysophosphatidic Acid
Acyltransferase, Theta)1
Lysophosphatidic Acid Acyltransferase Theta2 3     Lysophosphatidic Acid Acyltransferase1
1-AGP Acyltransferase 92 3     theta1
1-AGPAT 92 3     1-Acylglycerol-3-Phosphate O-Acyltransferase 82
GPAT-32 3     Endoplasmic Reticulum Associated GPAT2
GPAT32 3     Glycerol-3-Phosphate Acyltransferase 32
LPAAT-theta2 3     Lysophosphatidic Acid Acyltransferase, Theta2
MAG-12 3     

External Ids:    HGNC: 281571   Entrez Gene: 848032   Ensembl: ENSG000001386787   OMIM: 6109585   UniProtKB: Q53EU63   

Export aliases for AGPAT9 gene to outside databases

Previous GC identifers: GC04P084678 GC04P080200


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AGPAT9 Gene:
This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an
enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of
triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified.
(provided by RefSeq, Jan 2012)

GeneCards Summary for AGPAT9 Gene: 
AGPAT9 (1-acylglycerol-3-phosphate O-acyltransferase 9) is a protein-coding gene. Diseases associated with AGPAT9 include lung cancer, and toxoplasmosis, and among its related super-pathways are Glycerophospholipid biosynthesis and Metabolic pathways. GO annotations related to this gene include glycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT6.

UniProtKB/Swiss-Prot: GPAT3_HUMAN, Q53EU6
Function: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in
glycerolipid biosynthesis. Overexpression activates the mTOR pathway

Gene Wiki entry for AGPAT9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AGPAT9 gene promoter:
         COUP-TF1   RFX1   p53   Brachyury   MyoD   COUP   HNF-4alpha2   XBP-1   HNF-4alpha1   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAGPAT9 promoter sequence
   Search SABiosciences Chromatin IP Primers for AGPAT9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGPAT9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.23   Ensembl cytogenetic band:  4q21.23   HGNC cytogenetic band: 4q21.23

AGPAT9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGPAT9 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P084457:  view genomic region     (about GC identifiers)

Start:
84,457,067 bp from pter      End:
84,527,028 bp from pter
Size:
69,962 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GPAT3_HUMAN, Q53EU6 (See protein sequence)
Recommended Name: Glycerol-3-phosphate acyltransferase 3  
Size: 434 amino acids; 48705 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: Q68CJ4 Q6GPI6 Q96NA3

Explore the universe of human proteins at neXtProt for AGPAT9: NX_Q53EU6

Explore proteomics data for AGPAT9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q53EU6

  • 4/11 DME Specific Peptides for AGPAT9 (Q53EU6) (see all 11)
     YMKILVK  ILIFPEG  WDGGLKR  VWYMPPM 

    AGPAT9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AGPAT9 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001243350.1  NP_001243351.1  NP_116106.2  

    ENSEMBL proteins: 
     ENSP00000378651   ENSP00000264409  
    Reactome Protein details: Q53EU6
    Human Recombinant Protein Products for AGPAT9: 
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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA17170135
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--

    AGPAT9 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    AGPAT: 1-acylglycerol-3-phosphate O-acyltransferases

    1 InterPro protein domain:
     IPR002123 Plipid/glycerol_acylTrfase

    Graphical View of Domain Structure for InterPro Entry Q53EU6

    ProtoNet protein and cluster: Q53EU6

    1 Blocks protein domain: IPB002123 Phospholipid/glycerol acyltransferase

    UniProtKB/Swiss-Prot: GPAT3_HUMAN, Q53EU6
    Domain: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the
    phosphate moiety of the glycerol-3-phosphate (By similarity)
    Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


    AGPAT9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPAT3_HUMAN, Q53EU6
    Function: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in
    glycerolipid biosynthesis. Overexpression activates the mTOR pathway
    Catalytic activity: Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate
    Enzyme regulation: Inhibited by N-ethylmaleimide (NEM)

         Enzyme Number (IUBMB): EC 2.3.1.151 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity IEA--
    GO:0004366glycerol-3-phosphate O-acyltransferase activity IDA17170135
    GO:0016746transferase activity, transferring acyl groups ----
         
    AGPAT9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AGPAT9:
     Synthetic lethal with Ras 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidAGPAT9 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AGPAT9 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    3CDP-diacylglycerol biosynthesis I
    CDP-diacylglycerol biosynthesis I0.94
    triacylglycerol biosynthesis0.50
    phosphatidylglycerol biosynthesis II (non-plastidic)0.94
    4Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    5Fatty Acyl-CoA Biosynthesis
    Triglyceride Biosynthesis0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for AGPAT9
        CDP-diacylglycerol biosynthesis I
    triacylglycerol biosynthesis
    phosphatidylglycerol biosynthesis II (non-plastidic)

    5/7        Reactome Pathways for AGPAT9 (see all 7)
        Glycerophospholipid biosynthesis
    Synthesis of PA
    Metabolism
    Phospholipid metabolism
    Triglyceride Biosynthesis


    3         Kegg Pathways  (Kegg details for AGPAT9):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: GPAT3_HUMAN, Q53EU6
    Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis
    Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol
    3-phosphate: step 1/3


    AGPAT9 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AGPAT9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/28 Interacting proteins for AGPAT9 (Q53EU63 ENSP000002644094) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLN3Q132863I2D: score=1 
    EEF2KO004183I2D: score=1 
    AGPAT2ENSP000003607614STRING: ENSP00000360761
    AGPAT3ENSP000002915724STRING: ENSP00000291572
    AGPAT4ENSP000003140364STRING: ENSP00000314036
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006654phosphatidic acid biosynthetic process TAS--
    GO:0008152metabolic process ----
    GO:0016024CDP-diacylglycerol biosynthetic process IEA--
    GO:0019432triglyceride biosynthetic process TAS--

    AGPAT9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for AGPAT9 (GPAT3)

    10/331 HMDB Compounds for AGPAT9 (see all 331)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    Search CenterWatch for drugs/clinical trials and news about AGPAT9 / GPAT3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AGPAT9 gene (3 alternative transcripts): 
    NM_001256421.1  NM_001256422.1  NM_032717.4  

    Unigene Cluster for AGPAT9:

    1-acylglycerol-3-phosphate O-acyltransferase 9
    Hs.99196  [show with all ESTs]
    Unigene Representative Sequence: DQ345298
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514309 ENST00000506766 ENST00000395226(uc003how.3) ENST00000509412
    ENST00000264409(uc003hox.3 uc003hoy.3) ENST00000513683 ENST00000509044

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    Additional mRNA sequence: 

    AB075872.1 AK055749.1 AK223543.1 AY358100.1 BC006236.2 BC073136.1 BC090956.1 DQ324782.1 
    DQ345298.1 

    6 DOTS entries:

    DT.100718610  DT.111613  DT.100659709  DT.121274509  DT.121274576  DT.121274577 

    24/63 AceView cDNA sequences (see all 63):

    AA449236 BQ889869 CB119636 NM_032717 AA476677 AA449292 AI239607 CB122096 
    BP357230 BC073136 AK055749 BX098764 BM841009 AY358100 AW772099 BM795376 
    AB075872 BG171293 BP353081 BM271871 AA843870 AA887321 BM452132 CD557431 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT9    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:              -     -                                                                                             
    SP2:                                                                                                                  
    SP3:                    -                 -                                                                           
    SP4:        -     -     -                                                                                             


    ECgene alternative splicing isoforms for AGPAT9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AGPAT9 expression in normal human tissues (normalized intensities)      AGPAT9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGAATGT
    AGPAT9 Expression
    About this image


    AGPAT9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor ES-139
     
     Mesoderm (Gastrulation Derivatives)
             PureStem Z11, Meso Progenitor
     
     Cartilage (Muscoskeletal System)
             Intervertebral disc (IVD) annulus fibrosus (AF) cells
     
     Umbilical Cord (Extraembryonic Tissues)
             Human Umbilical Vein Smooth Muscle Cells (HUVSMC)   
     
     Adipose (Muscoskeletal System)
             Human Preadipocyte-subcutaneous (HPA-s)   

    See AGPAT9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AGPAT9

    SOURCE GeneReport for Unigene cluster: Hs.99196

    UniProtKB/Swiss-Prot: GPAT3_HUMAN, Q53EU6
    Tissue specificity: Widely expressed. Expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid,
    prostate, thymus and placenta. Also expressed lung and adipose tissue

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AGPAT9 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agpat91 , 5 1-acylglycerol-3-phosphate O-acyltransferase 91, 5 88.27(n)1
    94.68(a)1
      5 (48.52 cM)5
    2315101  NM_172715.31  NP_766303.11 
     1008457135 
    chicken
    (Gallus gallus)
    Aves AGPAT91 1-acylglycerol-3-phosphate O-acyltransferase 9 76.02(n)
    80.05(a)
      422610  NM_001031145.1  NP_001026316.1 
    lizard
    (Anolis carolinensis)
    Reptilia AGPAT96
    Uncharacterized protein
    78(a)
    1 ↔ 1
    5(43399150-43416058)
    zebrafish
    (Danio rerio)
    Actinopterygii agpat9l6
    agpat96
    1-acylglycerol-3-phosphate O-acyltransferase 9
    72(a)
    69(a)
    many → 1
    many → 1
    5(9317662-9349597)
    21(18116674-18132097)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG32096
    CG154506
    --
    44(a)
    40(a)
    many ↔ many
    many ↔ many
    2R(19956433-19961075)
    X(20693173-20696668)
    worm
    (Caenorhabditis elegans)
    Secernentea acl-56
    acl-46
    (see all 3)
    Protein ACL-4, isoform a
    (see all 3)
    37(a)
    34(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(10324183-10327456)
    X(2066556-2070460)
    corn
    (Zea mays)
    Liliopsida Zm.352 Maize 19 kDa zein mRNA, clone cZ19C1, complete cds 71.41(n)    AY104024.1 


    ENSEMBL Gene Tree for AGPAT9 (if available)
    TreeFam Gene Tree for AGPAT9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AGPAT9 gene
    AGPAT62  
    2 SIMAP similar genes for AGPAT9 using alignment to 1 protein entry:     GPAT3_HUMAN:
    DKFZp586M1819    AGPAT6

    AGPAT9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1599 SNPs in AGPAT9 are shown (see all 1599)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131542721,2
    C,F--84455123(+) ACCAAC/TTTTCC 1 -- us2k12Minor allele frequency- T:0.10CSA WA 119
    rs65354801,2
    C,F,A,H--84455200(+) AAAGAT/CGAGCC 1 -- us2k118Minor allele frequency- C:0.15NS EA NA WA CSA 1782
    rs1472900021,2
    --84455254(+) GCAAGA/GAAAAG 1 -- us2k10--------
    rs1399061581,2
    --84455299(+) CTGATC/GTCTGC 2 -- us2k10--------
    rs1498407241,2
    C--84455322(+) CATTTA/TCCATG 2 -- us2k10--------
    rs1458870121,2
    --84455381(+) CTGATA/GAGAAA 2 -- us2k10--------
    rs1149787761,2
    C,F--84455449(+) AGACTC/TCAAAT 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1925060391,2
    --84455503(+) TCTTCC/TGTAAC 3 -- us2k10--------
    rs1155751931,2
    F--84455542(+) TTTGTG/CGAGTT 3 -- us2k11Minor allele frequency- C:0.02WA 118
    rs65354811,2
    C,F,A,H--84455601(+) GCAAAG/ATTGTG 3 -- us2k124Minor allele frequency- A:0.30NA NS EA CSA WA 2488

    HapMap Linkage Disequilibrium report for AGPAT9 (84457067 - 84527028 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for AGPAT9:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676861CNV Deletion23128226
    esv2727904CNV Deletion23290073
    nsv829994CNV Loss17160897
    nsv829995CNV Loss17160897
    nsv879512CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610958    OMIM disorders: --

    6 diseases for AGPAT9:    About MalaCards
    lung cancer    toxoplasmosis    hepatoblastoma    thyroiditis
    gastric cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for AGPAT9:
    Toxoplasmosis

    AGPAT9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AGPAT9

    Export disorders for AGPAT9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AGPAT9 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with AGPAT9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    2. Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis. (PubMed id 17170135)1, 2 Cao J.... Gimeno R.E. (2006)
    3. Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway. (PubMed id 17002884)1, 2 Tang W....Yu L. (2006)
    4. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)1, 2 Yamada S....Nakagawara A. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. GPAT3 and GPAT4 are regulated by insulin-stimulated p hosphorylation and play distinct roles in adipogenesis. (PubMed id 20181984)1 Shan D....Cao J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84803 HGNC: 28157 AceView: MGC11324 Ensembl:ENSG00000138678 euGenes: HUgn84803
    ECgene: AGPAT9 Kegg: 84803 H-InvDB: AGPAT9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AGPAT9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AGPAT9 gene:
    Search GeneIP for patents involving AGPAT9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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