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AGPAT9 Gene

protein-coding   GIFtS: 58
GCID: GC04P084457

1-Acylglycerol-3-Phosphate O-Acyltransferase 9

(Previous names: 1-acylglycerol-3-phosphate O-acyltransferase 9 (lysophosphatidic...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
1-Acylglycerol-3-Phosphate O-Acyltransferase 91 2     AGPAT 102 3
GPAT32 3 5     hGPAT32 3
MAG12 3 5     EC 2.3.1.153 8
Acyl-CoA:Glycerol-3-Phosphate Acyltransferase 32 3     1-Acylglycerol-3-Phosphate O-Acyltransferase 9 (Lysophosphatidic Acid
Acyltransferase, Theta)1
Lung Cancer Metastasis-Associated Protein 12 3     Lysophosphatidic Acid Acyltransferase1
Lysophosphatidic Acid Acyltransferase Theta2 3     theta1
1-Acyl-Sn-Glycerol-3-Phosphate O-Acyltransferase 102 3     1-Acylglycerol-3-Phosphate O-Acyltransferase 82
1-Acyl-Sn-Glycerol-3-Phosphate O-Acyltransferase 92 3     AGPAT82
1-AGP Acyltransferase 92 3     Endoplasmic Reticulum Associated GPAT2
1-AGPAT 92 3     Glycerol-3-Phosphate Acyltransferase 32
GPAT-32 3     Lysophosphatidic Acid Acyltransferase, Theta2
LPAAT-theta2 3     EC 2.3.1.513
MAG-12 3     

External Ids:    HGNC: 281571   Entrez Gene: 848032   Ensembl: ENSG000001386787   OMIM: 6109585   UniProtKB: Q53EU63   

Export aliases for AGPAT9 gene to outside databases

Previous GC identifers: GC04P084678 GC04P080200


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AGPAT9 Gene:
This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an
enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of
triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified.
(provided by RefSeq, Jan 2012)

GeneCards Summary for AGPAT9 Gene:
AGPAT9 (1-acylglycerol-3-phosphate O-acyltransferase 9) is a protein-coding gene. Diseases associated with AGPAT9 include lung cancer, and toxoplasmosis. GO annotations related to this gene include glycerol-3-phosphate O-acyltransferase activity and 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT6.

UniProtKB/Swiss-Prot: GPAT3_HUMAN, Q53EU6
Function: May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential
step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of
1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3-phosphate
(phosphatidic acid, or PA)

Gene Wiki entry for AGPAT9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AGPAT9 gene promoter:
         COUP-TF1   RFX1   p53   Brachyury   MyoD   COUP   HNF-4alpha2   XBP-1   HNF-4alpha1   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAGPAT9 promoter sequence
   Search Chromatin IP Primers for AGPAT9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGPAT9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.23   Ensembl cytogenetic band:  4q21.23   HGNC cytogenetic band: 4q21.23

AGPAT9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGPAT9 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P084457:  view genomic region     (about GC identifiers)

Start:
84,457,067 bp from pter      End:
84,527,028 bp from pter
Size:
69,962 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GPAT3_HUMAN, Q53EU6 (See protein sequence)
Recommended Name: Glycerol-3-phosphate acyltransferase 3  
Size: 434 amino acids; 48705 Da
Caution: Despite its name, this protein appears to lack measurable glycerol-3-phosphate acyltransferase activity
under some conditions (PMID:19318427)
Secondary accessions: Q68CJ4 Q6GPI6 Q96NA3

Explore the universe of human proteins at neXtProt for AGPAT9: NX_Q53EU6

Explore proteomics data for AGPAT9 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys64
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for AGPAT9 (Q53EU6) (see all 11)
     YMKILVK  ILIFPEG  WDGGLKR  VWYMPPM 


    See AGPAT9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243350.1  NP_001243351.1  NP_116106.2  

    ENSEMBL proteins: 
     ENSP00000378651   ENSP00000264409  
    Reactome Protein details: Q53EU6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AGPAT: 1-acylglycerol-3-phosphate O-acyltransferases

    1 InterPro protein domain:
     IPR002123 Plipid/glycerol_acylTrfase

    Graphical View of Domain Structure for InterPro Entry Q53EU6

    ProtoNet protein and cluster: Q53EU6

    1 Blocks protein domain: IPB002123 Phospholipid/glycerol acyltransferase

    UniProtKB/Swiss-Prot: GPAT3_HUMAN, Q53EU6
    Domain: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the
    phosphate moiety of the glycerol-3-phosphate (By similarity)
    Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


    AGPAT9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPAT3_HUMAN, Q53EU6
    Function: May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential
    step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of
    1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3-phosphate
    (phosphatidic acid, or PA)
    Catalytic activity: Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate
    Catalytic activity: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
    Enzyme regulation: Inhibited by N-ethylmaleimide (NEM)

         Enzyme Numbers (IUBMB): EC 2.3.1.151 2 EC 2.3.1.511

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity IEA--
    GO:0004366glycerol-3-phosphate O-acyltransferase activity IDA17170135
    GO:0016746transferase activity, transferring acyl groups ----
         
    AGPAT9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AGPAT9:
     Synthetic lethal with Ras 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidAGPAT9 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPAT3_HUMAN, Q53EU6: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA17170135
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--

    AGPAT9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AGPAT9 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    Synthesis of PA0.33
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3triacylglycerol biosynthesis
    triacylglycerol biosynthesis0.48
    CDP-diacylglycerol biosynthesis I0.00
    phosphatidylglycerol biosynthesis II (non-plastidic)0.48
    4Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    5Triglyceride Biosynthesis
    Triglyceride Biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for AGPAT9
        CDP-diacylglycerol biosynthesis I
    triacylglycerol biosynthesis
    phosphatidylglycerol biosynthesis II (non-plastidic)

    2 Reactome Pathways for AGPAT9
        Synthesis of PA
    Triglyceride Biosynthesis


    3 Kegg Pathways  (Kegg details for AGPAT9):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: GPAT3_HUMAN, Q53EU6
    Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis
    Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol
    3-phosphate: step 1/3


    AGPAT9 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AGPAT9
    Interactions:

        Search GeneGlobe Interaction Network for AGPAT9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AGPAT9 (Q53EU63 ENSP000002644094) via UniProtKB, MINT, STRING, and/or I2D (see all 34)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF2KO004183, ENSP000002630264I2D: score=1 STRING: ENSP00000263026
    CLN3Q132863I2D: score=1 
    AGPAT2ENSP000003607614STRING: ENSP00000360761
    AGPAT3ENSP000002915724STRING: ENSP00000291572
    AGPAT4ENSP000003140364STRING: ENSP00000314036
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006654phosphatidic acid biosynthetic process TAS--
    GO:0008152metabolic process ----
    GO:0016024CDP-diacylglycerol biosynthetic process IEA--
    GO:0019432triglyceride biosynthetic process TAS--

    AGPAT9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AGPAT9 (GPAT3)

    Selected HMDB Compounds for AGPAT9 (see all 331)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AGPAT9 gene (3 alternative transcripts): 
    NM_001256421.1  NM_001256422.1  NM_032717.4  

    Unigene Cluster for AGPAT9:

    1-acylglycerol-3-phosphate O-acyltransferase 9
    Hs.99196  [show with all ESTs]
    Unigene Representative Sequence: DQ345298
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514309 ENST00000506766 ENST00000395226(uc003how.3) ENST00000509412
    ENST00000264409(uc003hox.3 uc003hoy.3) ENST00000513683 ENST00000509044

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    Additional mRNA sequence: 

    AB075872.1 AK055749.1 AK223543.1 AY358100.1 BC006236.2 BC073136.1 BC090956.1 DQ324782.1 
    DQ345298.1 

    6 DOTS entries:

    DT.100718610  DT.111613  DT.100659709  DT.121274509  DT.121274576  DT.121274577 

    Selected AceView cDNA sequences (see all 63):

    AA449236 BP357230 NM_032717 AW772099 BX098764 BQ889869 CB122096 AA476677 
    CB119636 AA449292 BC073136 AK055749 AY358100 BM841009 AI239607 AA887296 
    AA843870 AA514936 BV196781 CB115554 BM551856 BG171293 CD557431 AA398819 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT9    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:              -     -                                                                                             
    SP2:                                                                                                                  
    SP3:                    -                 -                                                                           
    SP4:        -     -     -                                                                                             


    ECgene alternative splicing isoforms for AGPAT9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AGPAT9 expression in normal human tissues (normalized intensities)      AGPAT9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGAATGT
    AGPAT9 Expression
    About this image


    AGPAT9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Cartilage (Muscoskeletal System)
             Intervertebral disc (IVD) annulus fibrosus (AF) cells
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    AGPAT9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AGPAT9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.99196

    UniProtKB/Swiss-Prot: GPAT3_HUMAN, Q53EU6
    Tissue specificity: Widely expressed. Expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid,
    prostate, thymus and placenta. Also expressed lung and adipose tissue

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AGPAT9 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agpat91 , 5 1-acylglycerol-3-phosphate O-acyltransferase 91, 5 88.27(n)1
    94.68(a)1
      5 (48.52 cM)5
    2315101  NM_172715.31  NP_766303.11 
     1008457135 
    chicken
    (Gallus gallus)
    Aves AGPAT91 1-acylglycerol-3-phosphate O-acyltransferase 9 76.02(n)
    80.05(a)
      422610  NM_001031145.1  NP_001026316.1 
    lizard
    (Anolis carolinensis)
    Reptilia AGPAT96
    1-acylglycerol-3-phosphate O-acyltransferase 9
    78(a)
    1 ↔ 1
    5(43399150-43416058)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004857871 glycerol-3-phosphate acyltransferase 3-like 74(n)
    78.69(a)
      100485787  XM_002939586.2  XP_002939632.2 
    zebrafish
    (Danio rerio)
    Actinopterygii agpat9l6
    agpat96
    1-acylglycerol-3-phosphate O-acyltransferase 9
    71(a)
    69(a)
    many → 1
    many → 1
    5(9317662-9349597) ENSDARG00000006491
    21(18116674-18132097) ENSDARG00000016048
    fruit fly
    (Drosophila melanogaster)
    Insecta CG32096
    CG154506
    --
    44(a)
    38(a)
    many ↔ many
    many ↔ many
    2R(19956433-19961075)
    X(20693173-20696668)
    worm
    (Caenorhabditis elegans)
    Secernentea acl-56
    acl-46
    (see all 3)
    Protein ACL-5, isoform a
    Protein ACL-4, isoform b (acl-4) mRNA, complete cd...
    (see all 3)
    37(a)
    35(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(10324183-10327456) WBGene00011106
    X(2066556-2070460) WBGene00018657
    corn
    (Zea mays)
    Liliopsida Zm.352 Maize 19 kDa zein mRNA, clone cZ19C1, complete cds 71.41(n)    AY104024.1 


    ENSEMBL Gene Tree for AGPAT9 (if available)
    TreeFam Gene Tree for AGPAT9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AGPAT9 gene
    AGPAT62  
    2 SIMAP similar genes for AGPAT9 using alignment to 1 protein entry:     GPAT3_HUMAN:
    DKFZp586M1819    AGPAT6

    AGPAT9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AGPAT9 (see all 1599)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131542721,2
    C,F--84455123(+) ACCAAC/TTTTCC 1 -- us2k12Minor allele frequency- T:0.10CSA WA 119
    rs65354801,2
    C,F,A,H--84455200(+) AAAGAT/CGAGCC 1 -- us2k118Minor allele frequency- C:0.15NS EA NA WA CSA 1782
    rs1472900021,2
    --84455254(+) GCAAGA/GAAAAG 1 -- us2k10--------
    rs1399061581,2
    --84455299(+) CTGATC/GTCTGC 2 -- us2k10--------
    rs1498407241,2
    C--84455322(+) CATTTA/TCCATG 2 -- us2k10--------
    rs1458870121,2
    --84455381(+) CTGATA/GAGAAA 2 -- us2k10--------
    rs1149787761,2
    C,F--84455449(+) AGACTC/TCAAAT 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1925060391,2
    --84455503(+) TCTTCC/TGTAAC 3 -- us2k10--------
    rs1155751931,2
    F--84455542(+) TTTGTG/CGAGTT 3 -- us2k11Minor allele frequency- C:0.02WA 118
    rs65354811,2
    C,F,A,H--84455601(+) GCAAAG/ATTGTG 3 -- us2k124Minor allele frequency- A:0.30NA NS EA CSA WA 2488

    HapMap Linkage Disequilibrium report for AGPAT9 (84457067 - 84527028 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for AGPAT9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676861CNV Deletion23128226
    esv2727904CNV Deletion23290073
    nsv829994CNV Loss17160897
    nsv829995CNV Loss17160897
    nsv879512CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AGPAT9
    DNA2.0 Custom Variant and Variant Library Synthesis for AGPAT9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610958    OMIM disorders: --

    6 diseases for AGPAT9:    About MalaCards
    lung cancer    toxoplasmosis    hepatoblastoma    obesity
    thyroiditis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for AGPAT9:
    Toxoplasmosis

    AGPAT9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AGPAT9

    Export disorders for AGPAT9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AGPAT9 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with AGPAT9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis. (PubMed id 17170135)1, 2 Cao J.... Gimeno R.E. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    3. Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway. (PubMed id 17002884)1, 2 Tang W....Yu L. (J. Biochem. Mol. Biol. 2006)
    4. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)1, 2 Yamada S....Nakagawara A. (Oncogene 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Metastasis-associated gene, mag-1 improves tumour microenvironmental adaptation and potentiates tumour metastasis. (PubMed id 22985252)1 Wang Y....Lu Y. (J. Cell. Mol. Med. 2012)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84803 HGNC: 28157 AceView: MGC11324 Ensembl:ENSG00000138678 euGenes: HUgn84803
    ECgene: AGPAT9 Kegg: 84803 H-InvDB: AGPAT9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AGPAT9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AGPAT9 gene:
    Search GeneIP for patents involving AGPAT9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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