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GIFtS

AGPAT6 Gene

protein-coding   GIFtS: 57
GCID: GC08P041435

1-Acylglycerol-3-Phosphate O-Acyltransferase 6

(Previous names: 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic...)
  Search for AGPAT6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
1-Acylglycerol-3-Phosphate O-Acyltransferase 61 2 3     Lysophosphatidic Acid Acyltransferase1
1-Acylglycerol-3-Phosphate O-Acyltransferase 6 (Lysophosphatidic Acid
Acyltransferase, Zeta)1 2
     zeta1
Lysophosphatidic Acid Acyltransferase Zeta2 3     1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Zeta2
1-AGP Acyltransferase 62 3     TSARG72
1-AGPAT 62 3     Glycerol-3-Phosphate Acyltransferase 62
LPAAT-zeta2 3     Testis Spermatogenesis Apoptosis-Related Protein 72
EC 2.3.1.153 8     GPAT43
LPAATZ2 5     Acyl-CoA:Glycerol-3-Phosphate Acyltransferase 43

External Ids:    HGNC: 208801   Entrez Gene: 1379642   Ensembl: ENSG000001586697   OMIM: 6081435   UniProtKB: Q86UL33   

Export aliases for AGPAT6 gene to outside databases

Previous GC identifers: GC08U900560 GC08P041555 GC08P039963


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AGPAT6 Gene:
Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to
phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.(supplied by OMIM,
Apr 2004)

GeneCards Summary for AGPAT6 Gene: 
AGPAT6 (1-acylglycerol-3-phosphate O-acyltransferase 6) is a protein-coding gene. Among its related super-pathways are Glycerophospholipid biosynthesis and Metabolic pathways. GO annotations related to this gene include glycerol-3-phosphate O-acyltransferase activity and 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT9.

UniProtKB/Swiss-Prot: GPAT4_HUMAN, Q86UL3
Function: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in
glycerolipid biosynthesis. Active against both saturated and unsaturated long-chain fatty acyl-CoAs




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AGPAT6 gene promoter:
         GCNF-1   GCNF   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAGPAT6 promoter sequence
   Search SABiosciences Chromatin IP Primers for AGPAT6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGPAT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.21   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p11.21

AGPAT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGPAT6 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P041435:  view genomic region     (about GC identifiers)

Start:
41,434,706 bp from pter      End:
41,482,520 bp from pter
Size:
47,815 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GPAT4_HUMAN, Q86UL3 (See protein sequence)
Recommended Name: Glycerol-3-phosphate acyltransferase 4 precursor  
Size: 456 amino acids; 52071 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: Q86V89

Explore the universe of human proteins at neXtProt for AGPAT6: NX_Q86UL3

Explore proteomics data for AGPAT6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86UL3

  • 4/10 DME Specific Peptides for AGPAT6 (Q86UL3) (see all 10)
     ILIFPEG  WDGGLKR  FKEEQQK  YSKMIVGN 

    AGPAT6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AGPAT6 Protein Expression
    REFSEQ proteins: NP_848934.1  
    ENSEMBL proteins: 
     ENSP00000380184   ENSP00000429477   ENSP00000428648   ENSP00000428630  
    Reactome Protein details: Q86UL3
    Human Recombinant Protein Products for AGPAT6: 
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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ISS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016020membrane IDA18238778
    GO:0016021integral to membrane NAS18238778

    AGPAT6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    AGPAT: 1-acylglycerol-3-phosphate O-acyltransferases

    1 InterPro protein domain:
     IPR002123 Plipid/glycerol_acylTrfase

    Graphical View of Domain Structure for InterPro Entry Q86UL3

    ProtoNet protein and cluster: Q86UL3

    1 Blocks protein domain: IPB002123 Phospholipid/glycerol acyltransferase

    UniProtKB/Swiss-Prot: GPAT4_HUMAN, Q86UL3
    Domain: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the
    phosphate moiety of the glycerol-3-phosphate (By similarity)
    Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


    AGPAT6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPAT4_HUMAN, Q86UL3
    Function: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in
    glycerolipid biosynthesis. Active against both saturated and unsaturated long-chain fatty acyl-CoAs
    Catalytic activity: Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate
    Enzyme regulation: Inhibited by N-ethylmaleimide (NEM)

         Enzyme Number (IUBMB): EC 2.3.1.151 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003841NOT 1-acylglycerol-3-phosphate O-acyltransferase activity IDA18238778
    GO:0004366glycerol-3-phosphate O-acyltransferase activity IDA18238778
    GO:0016746transferase activity, transferring acyl groups ----
         
    AGPAT6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for AGPAT6:
     Increased cell number in G1, s  Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Agpat6):
     endocrine/exocrine gland  integument 

    AGPAT6 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AGPAT6 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    3CDP-diacylglycerol biosynthesis I
    CDP-diacylglycerol biosynthesis I0.94
    triacylglycerol biosynthesis0.50
    phosphatidylglycerol biosynthesis II (non-plastidic)0.94
    4Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    5Fatty Acyl-CoA Biosynthesis
    Triglyceride Biosynthesis0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for AGPAT6
        CDP-diacylglycerol biosynthesis I
    triacylglycerol biosynthesis
    phosphatidylglycerol biosynthesis II (non-plastidic)


    5/7        Reactome Pathways for AGPAT6 (see all 7)
        Glycerophospholipid biosynthesis
    Synthesis of PA
    Metabolism
    Phospholipid metabolism
    Triglyceride Biosynthesis


    3         Kegg Pathways  (Kegg details for AGPAT6):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: GPAT4_HUMAN, Q86UL3
    Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol
    3-phosphate: step 1/3


    AGPAT6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AGPAT6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for AGPAT6 (Q86UL32, 3 ENSP000003801844) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2878767 I2D: score=2 STRING: ENSP00000344782
    CLN3Q132863I2D: score=1 
    WIPI2Q9Y4P83I2D: score=1 
    AGPAT2ENSP000003607614STRING: ENSP00000360761
    AGPAT3ENSP000002915724STRING: ENSP00000291572
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002071glandular epithelial cell maturation IEA--
    GO:0006631fatty acid metabolic process IEA--
    GO:0006637acyl-CoA metabolic process IDA18238778
    GO:0006641triglyceride metabolic process ----
    GO:0006644phospholipid metabolic process TAS--

    AGPAT6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for AGPAT6 (GPAT4)

    10/52 HMDB Compounds for AGPAT6 (see all 52)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    Search CenterWatch for drugs/clinical trials and news about AGPAT6 / GPAT4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for AGPAT6 gene: 
    NM_178819.3  

    Unigene Cluster for AGPAT6:

    1-acylglycerol-3-phosphate O-acyltransferase 6
    Hs.355753  [show with all ESTs]
    Unigene Representative Sequence: NM_178819
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521184 ENST00000520258 ENST00000396987(uc003xnz.2) ENST00000519853
    ENST00000520223 ENST00000521121 ENST00000521806 ENST00000519921 ENST00000523906
    ENST00000521349 ENST00000518628
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    Additional mRNA sequence: 

    AF317516.1 AF406612.1 AL834255.1 AY358670.1 AY513610.1 BC051377.1 BC061884.1 

    17 DOTS entries:

    DT.112557  DT.109594  DT.40236707  DT.92439515  DT.100821830  DT.100821824  DT.100821827  DT.203468 
    DT.100821826  DT.100821831  DT.120632030  DT.95318062  DT.100029723  DT.100821822  DT.95117631  DT.95318057 
    DT.99973307 

    24/292 AceView cDNA sequences (see all 292):

    BQ019288 AW778973 AW503240 CF125497 AI040580 CA454436 CF125333 BX417752 
    CR617473 BF222022 BM727017 F34639 BU859078 CA391179 AA481914 BE794126 
    BE740490 AY358670 BQ439643 BF724592 BF663445 BE732516 AI470921 AI621173 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT6 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^
    SP1:              -     -     -                                                                 -     -                       -                       -         
    SP2:                                                                                            -     -     -                 -                       -         
    SP3:                                                                                            -                                                               
    SP4:                                                                                                                                                  -         
    SP5:                                      -     -     -     -                                                                                                   

    ExUns: 17a · 17b ^ 18a · 18b
    SP1:        -               
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for AGPAT6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AGPAT6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATGCGCGC
    AGPAT6 Expression
    About this image


    See AGPAT6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AGPAT6

    SOURCE GeneReport for Unigene cluster: Hs.355753

    UniProtKB/Swiss-Prot: GPAT4_HUMAN, Q86UL3
    Tissue specificity: Ubiquitous. Relatively high level of expression in skeletal muscle, heart and testis.
    Relatively low level of expression in lung

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AGPAT6 gene from 9/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agpat61 , 5 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic more1, 5 88.6(n)1
    97.59(a)1
      8 (11.42 cM)5
    1022471  NM_018743.41  NP_061213.21 
     231729465 
    chicken
    (Gallus gallus)
    Aves AGPAT61 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic more 82.78(n)
    95.82(a)
      426788  XM_424400.3  XP_424400.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    94(a)
    91(a)
    1 ↔ many
    1 ↔ many
    GL343578.1(367692-382667)
    AAWZ02039369(341-8719)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX844245.12   -- 79.86(n)    BX844245.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi89e032 wufi89e03 76.04(n)   334492  57070545 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG32096
    CG154506
    --
    42(a)
    36(a)
    many ↔ many
    many ↔ many
    2R(19956433-19961075)
    X(20693173-20696668)
    worm
    (Caenorhabditis elegans)
    Secernentea acl-41 Protein ACL-4 55.86(n)
    51.49(a)
      180519  NM_075978.3  NP_508379.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GPAT91 glycerol-3-phosphate acyltransferase 9 49.81(n)
    39.94(a)
      836183  NM_125455.3  NP_568925.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g05316001 hypothetical protein 49.13(n)
    41.23(a)
      4343455  NM_001066388.1  NP_001059853.1 


    ENSEMBL Gene Tree for AGPAT6 (if available)
    TreeFam Gene Tree for AGPAT6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AGPAT6 gene
    AGPAT92  
    2 SIMAP similar genes for AGPAT6 using alignment to 5 protein entries:     GPAT4_HUMAN (see all proteins):
    DKFZp586M1819    AGPAT9

    AGPAT6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for AGPAT6
    PGOHUM00000247750


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1062 SNPs in AGPAT6 are shown (see all 1062)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1450652801,2
    --41433785(+) TATGAC/TGTCTG 1 -- us2k10--------
    rs58911581,2
    C,F--41433802(+) tttttT/-ttttt 1 -- us2k12Minor allele frequency- -:0.50NA 4
    rs1878266721,2
    --41433823(+) CTGAGA/GTGGAG 1 -- us2k10--------
    rs1479509921,2
    --41433864(+) TGGTGC/TGATCT 1 -- us2k10--------
    rs1419079451,2
    C--41433949(+) GGTGCA/C/GCACCA 1 -- us2k10--------
    rs1921532871,2
    --41433958(+) CACCAC/TGCCCG 1 -- us2k10--------
    rs1842370011,2
    --41433960(+) CCACGC/GCCGGC 1 -- us2k10--------
    rs101010211,2
    C--41434037(+) atgccC/Tgacct 1 -- us2k10--------
    rs762564701,2
    C,F--41434131(+) TTTAAT/CGTCGT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1126185581,2
    C,F--41434135(+) ATGTCG/ATTGAC 1 -- us2k12Minor allele frequency- A:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for AGPAT6 (41434706 - 41482520 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for AGPAT6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831299CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    AGPAT6 for disorders           About MalaCards
    OMIM gene information: 608143    OMIM disorders: --


    AGPAT6 for disorders           About GeneDecksing


    Export disorders for AGPAT6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AGPAT6 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with AGPAT6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family. (PubMed id 12938015)1, 2, 3 Li D.... Zhao S. (2003)
    2. AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. (PubMed id 18238778)1, 2, 9 Chen Y.Q.... Cao G. (2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. GPAT3 and GPAT4 are regulated by insulin-stimulated p hosphorylation and play distinct roles in adipogenesis. (PubMed id 20181984)1 Shan D....Cao J. (2010)
    8. Molecular cloning and preliminary function study of a novel human gene, TSARG7, related to spermatogenesis. (PubMed id 16625827)1 Tan X.-J....Lu G.-X. (2006)
    9. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 137964 HGNC: 20880 AceView: DKFZp586M1819 Ensembl:ENSG00000158669 euGenes: HUgn137964
    ECgene: AGPAT6 Kegg: 137964 H-InvDB: AGPAT6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AGPAT6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AGPAT6 gene:
    Search GeneIP for patents involving AGPAT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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