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Aliases for AGPAT6 Gene

Aliases for AGPAT6 Gene

  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 6 2 3 4
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 6 (Lysophosphatidic Acid Acyltransferase, Zeta) 2 3
  • Lysophosphatidic Acid Acyltransferase Zeta 3 4
  • 1-AGP Acyltransferase 6 3 4
  • EC 4 63
  • LPAAT-Zeta 3 4
  • 1-AGPAT 6 3 4
  • LPAATZ 3 6
  • 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Zeta 3
  • Testis Spermatogenesis Apoptosis-Related Protein 7 3
  • Acyl-CoA:Glycerol-3-Phosphate Acyltransferase 4 4
  • Glycerol-3-Phosphate Acyltransferase 6 3
  • Lysophosphatidic Acid Acyltransferase 2
  • TSARG7 3
  • GPAT4 4
  • Zeta 2

External Ids for AGPAT6 Gene

Previous GeneCards Identifiers for AGPAT6 Gene

  • GC08U900560
  • GC08P041435
  • GC08P039963

Summaries for AGPAT6 Gene

Entrez Gene Summary for AGPAT6 Gene

  • Lysophosphatidic acid acyltransferases (EC catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]

GeneCards Summary for AGPAT6 Gene

AGPAT6 (1-Acylglycerol-3-Phosphate O-Acyltransferase 6) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include 1-acylglycerol-3-phosphate O-acyltransferase activity and glycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT9.

UniProtKB/Swiss-Prot for AGPAT6 Gene

  • Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long-chain fatty acyl-CoAs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGPAT6 Gene

Genomics for AGPAT6 Gene

Regulatory Elements for AGPAT6 Gene

Transcription factor binding sites by QIAGEN in the AGPAT6 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AGPAT6 Gene

41,577,187 bp from pter
41,625,001 bp from pter
47,815 bases
Plus strand

Genomic View for AGPAT6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGPAT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGPAT6 Gene

Proteins for AGPAT6 Gene

  • Protein details for AGPAT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycerol-3-phosphate acyltransferase 4
    Protein Accession:
    Secondary Accessions:
    • Q86V89

    Protein attributes for AGPAT6 Gene

    456 amino acids
    Molecular mass:
    52071 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AGPAT6 Gene

Proteomics data for AGPAT6 Gene at MOPED

Post-translational modifications for AGPAT6 Gene

  • Ubiquitination at Lys426
  • Glycosylation at Asn247, Asn327, Asn328, and Asn362
  • Modification sites at PhosphoSitePlus

Other Protein References for AGPAT6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for AGPAT6 Gene

Gene Families for AGPAT6 Gene

  • AGPAT :1-acylglycerol-3-phosphate O-acyltransferases

Protein Domains for AGPAT6 Gene

Suggested Antigen Peptide Sequences for AGPAT6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q86UL3
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with AGPAT6: view

Function for AGPAT6 Gene

Molecular function for AGPAT6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethylmaleimide (NEM).
UniProtKB/Swiss-Prot Function:
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long-chain fatty acyl-CoAs.

Enzyme Numbers (IUBMB) for AGPAT6 Gene

Gene Ontology (GO) - Molecular Function for AGPAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 NOT 1-acylglycerol-3-phosphate O-acyltransferase activity IDA 18238778
GO:0004366 glycerol-3-phosphate O-acyltransferase activity IDA 18238778
GO:0016746 transferase activity, transferring acyl groups --
genes like me logo Genes that share ontologies with AGPAT6: view

Phenotypes for AGPAT6 Gene

genes like me logo Genes that share phenotypes with AGPAT6: view

Animal Model Products

miRNA for AGPAT6 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGPAT6

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for AGPAT6 Gene

Localization for AGPAT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGPAT6 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for AGPAT6 Gene COMPARTMENTS Subcellular localization image for AGPAT6 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for AGPAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 18238778
GO:0016021 integral component of membrane NAS 18238778
genes like me logo Genes that share ontologies with AGPAT6: view

Pathways for AGPAT6 Gene

genes like me logo Genes that share pathways with AGPAT6: view

UniProtKB/Swiss-Prot Q86UL3-GPAT4_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3

Gene Ontology (GO) - Biological Process for AGPAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002071 glandular epithelial cell maturation IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006637 acyl-CoA metabolic process IDA 18238778
GO:0006641 triglyceride metabolic process --
GO:0006644 phospholipid metabolic process TAS --
genes like me logo Genes that share ontologies with AGPAT6: view

Compounds for AGPAT6 Gene

(52) HMDB Compounds for AGPAT6 Gene

Compound Synonyms Cas Number PubMed IDs
  • (E)-S-2-decenoate Coenzyme A
  • 2-trans-Dodecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
  • (2E)-Tetradecenoyl-Coenzyme A
genes like me logo Genes that share compounds with AGPAT6: view

Transcripts for AGPAT6 Gene

Unigene Clusters for AGPAT6 Gene

1-acylglycerol-3-phosphate O-acyltransferase 6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGPAT6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^
SP1: - - - - - - -
SP2: - - - - -
SP3: -
SP4: -
SP5: - - - -
SP6: -
SP7: - -
SP8: - -
SP10: - -

ExUns: 17a · 17b ^ 18a · 18b
SP1: -
SP9: -

Relevant External Links for AGPAT6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AGPAT6 Gene

mRNA expression in normal human tissues for AGPAT6 Gene

Protein differential expression in normal tissues for AGPAT6 Gene

This gene is overexpressed in Adrenal (43.6) and Breast (11.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGPAT6 Gene

SOURCE GeneReport for Unigene cluster for AGPAT6 Gene Hs.355753

mRNA Expression by UniProt/SwissProt for AGPAT6 Gene

Tissue specificity: Ubiquitous. Relatively high level of expression in skeletal muscle, heart and testis. Relatively low level of expression in lung.
genes like me logo Genes that share expressions with AGPAT6: view

Expression partners for AGPAT6 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AGPAT6 Gene

Orthologs for AGPAT6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AGPAT6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AGPAT6 35
  • 88.45 (n)
  • 97.37 (a)
  • 98 (a)
(Canis familiaris)
Mammalia AGPAT6 35
  • 92.76 (n)
  • 98.9 (a)
  • 99 (a)
(Mus musculus)
Mammalia Agpat6 35
  • 88.6 (n)
  • 97.59 (a)
Agpat6 16
Agpat6 36
  • 98 (a)
(Pan troglodytes)
Mammalia AGPAT6 35
  • 99.63 (n)
  • 99.78 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Agpat6 35
  • 89.18 (n)
  • 97.15 (a)
(Monodelphis domestica)
Mammalia AGPAT6 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia AGPAT6 36
  • 49 (a)
(Gallus gallus)
Aves AGPAT6 35
  • 82.78 (n)
  • 95.82 (a)
  • 96 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 91 (a)
-- 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia agpat6 35
  • 75.79 (n)
  • 85.65 (a)
(Danio rerio)
Actinopterygii agpat6 35
  • 73.9 (n)
  • 81.21 (a)
wufi89e03 35
agpat6 36
  • 80 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002084 35
  • 59.28 (n)
  • 55.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3209 35
  • 57.81 (n)
  • 54.64 (a)
CG15450 36
  • 36 (a)
CG3209 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea acl-4 35
  • 57.61 (n)
  • 56.42 (a)
acl-4 36
  • 35 (a)
acl-5 36
  • 39 (a)
M79.2 36
  • 25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons GPAT9 35
  • 49.81 (n)
  • 39.94 (a)
(Oryza sativa)
Liliopsida Os07g0531600 35
  • 49.13 (n)
  • 41.23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1550 36
  • 46 (a)
Species with no ortholog for AGPAT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGPAT6 Gene

Gene Tree for AGPAT6 (if available)
Gene Tree for AGPAT6 (if available)

Paralogs for AGPAT6 Gene

Paralogs for AGPAT6 Gene

Selected SIMAP similar genes for AGPAT6 Gene using alignment to 5 proteins: Pseudogenes for AGPAT6 Gene

genes like me logo Genes that share paralogs with AGPAT6: view

Variants for AGPAT6 Gene

Sequence variations from dbSNP and Humsavar for AGPAT6 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs9559 -- 41,624,749(+) TTGAT(C/T)ATTTC utr-variant-3-prime
rs543743 -- 41,620,273(+) TGTAA(C/T)GAAAC intron-variant
rs749540 -- 41,623,577(+) TCTCT(A/G)TTTTT utr-variant-3-prime
rs749541 -- 41,623,705(+) CTTGA(A/G)GGTGA utr-variant-3-prime
rs755552 -- 41,605,119(+) AAATA(C/T)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGPAT6 Gene

Variant ID Type Subtype PubMed ID
nsv831299 CNV Loss 17160897

Relevant External Links for AGPAT6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGPAT6 Gene

Disorders for AGPAT6 Gene

No disorders were found for AGPAT6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for AGPAT6 Gene

Publications for AGPAT6 Gene

  1. Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family. (PMID: 12938015) Li D. … Zhao S. (J. Hum. Genet. 2003) 2 3 4
  2. AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. (PMID: 18238778) Chen Y.Q. … Cao G. (J. Biol. Chem. 2008) 3 4 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Molecular cloning and preliminary function study of a novel human gene, TSARG7, related to spermatogenesis. (PMID: 16625827) Tan X.-J. … Lu G.-X. (Yi Chuan Xue Bao 2006) 3

Products for AGPAT6 Gene

Sources for AGPAT6 Gene

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