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Aliases for AGPAT5 Gene

Aliases for AGPAT5 Gene

  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 5 2 3 4 5
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 5 (Lysophosphatidic Acid Acyltransferase, Epsilon) 2 3
  • Lysophosphatidic Acid Acyltransferase Epsilon 3 4
  • 1-AGP Acyltransferase 5 3 4
  • 1-AGPAT 5 3 4
  • 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Epsilon 3
  • Lysophosphatidic Acid Acyltransferase, Epsilon 2
  • Testicular Tissue Protein Li 144 3
  • LPAAT-Epsilon 4
  • EC 2.3.1.51 4
  • 1AGPAT5 3
  • LPAATE 3

External Ids for AGPAT5 Gene

Previous GeneCards Identifiers for AGPAT5 Gene

  • GC08P006554
  • GC08P006346

Summaries for AGPAT5 Gene

Entrez Gene Summary for AGPAT5 Gene

  • This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014]

GeneCards Summary for AGPAT5 Gene

AGPAT5 (1-Acylglycerol-3-Phosphate O-Acyltransferase 5) is a Protein Coding gene. Among its related pathways are Metabolism and Acyl chain remodelling of PE. GO annotations related to this gene include transferase activity, transferring acyl groups and 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT3.

UniProtKB/Swiss-Prot for AGPAT5 Gene

  • Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable.

Gene Wiki entry for AGPAT5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGPAT5 Gene

Genomics for AGPAT5 Gene

Regulatory Elements for AGPAT5 Gene

Enhancers for AGPAT5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F006744 1.6 FANTOM5 Ensembl ENCODE 24.4 +39.5 39483 7.2 HDGF YBX1 ZNF48 GATA2 CBX5 ZNF143 ZNF207 JUNB TBX21 CREB3 AGPAT5 MCPH1-AS1 MCPH1 ANGPT2 OR7E154P MIR4659B PIR35931
GH08F006731 1.1 Ensembl ENCODE 20.9 +25.0 25045 3.5 HDGF WRNIP1 ZNF133 SIN3A ZBTB40 GATA2 SCRT2 ZNF362 SMARCA4 KLF16 AGPAT5 MCPH1-AS1 MIR4659A LOC100422495
GH08F006777 1.2 FANTOM5 Ensembl ENCODE 18.9 +70.4 70354 2.3 CTCF MAZ ZNF654 TBL1XR1 WRNIP1 TRIM22 REST RAD21 RFX5 ZFP3 AGPAT5 MCPH1-AS1 ANGPT2 PIR35931 MIR4659B
GH08F006735 0.9 ENCODE 22.9 +28.0 28012 2.1 HDGF ELF3 TBP CBX3 TBL1XR1 WRNIP1 ARID4B DMAP1 THRB ZSCAN9 AGPAT5 MCPH1-AS1 MIR4659A LOC100422495
GH08F006727 0.9 Ensembl ENCODE 21.2 +20.4 20387 3.1 JUND MTA2 IKZF1 JUN NBN JUNB PRDM1 ZBTB40 SPI1 AGPAT5 MCPH1-AS1 ANGPT2 LOC100422495 MIR4659A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AGPAT5 on UCSC Golden Path with GeneCards custom track

Promoters for AGPAT5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001384970 743 3800 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for AGPAT5 Gene

Chromosome:
8
Start:
6,708,357 bp from pter
End:
6,761,503 bp from pter
Size:
53,147 bases
Orientation:
Plus strand

Genomic View for AGPAT5 Gene

Genes around AGPAT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGPAT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGPAT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGPAT5 Gene

Proteins for AGPAT5 Gene

  • Protein details for AGPAT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUQ2-PLCE_HUMAN
    Recommended name:
    1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon
    Protein Accession:
    Q9NUQ2
    Secondary Accessions:
    • Q8IZ47
    • Q9BQG4

    Protein attributes for AGPAT5 Gene

    Size:
    364 amino acids
    Molecular mass:
    42072 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92069.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for AGPAT5 Gene

Post-translational modifications for AGPAT5 Gene

  • Ubiquitination at Lys 183
  • Modification sites at PhosphoSitePlus

Other Protein References for AGPAT5 Gene

No data available for DME Specific Peptides for AGPAT5 Gene

Domains & Families for AGPAT5 Gene

Gene Families for AGPAT5 Gene

Protein Domains for AGPAT5 Gene

Suggested Antigen Peptide Sequences for AGPAT5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NUQ2

UniProtKB/Swiss-Prot:

PLCE_HUMAN :
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with AGPAT5: view

Function for AGPAT5 Gene

Molecular function for AGPAT5 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=5.52 uM for LPA sn-1 C18:1; KM=16.30 uM for C18:1-CoA; Vmax=2.42 nmol/min/mg enzyme toward LPA sn-1 C18:1; Vmax=1.22 nmol/min/mg enzyme toward C18:1-CoA;
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot Function:
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable.

Enzyme Numbers (IUBMB) for AGPAT5 Gene

Gene Ontology (GO) - Molecular Function for AGPAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with AGPAT5: view
genes like me logo Genes that share phenotypes with AGPAT5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AGPAT5

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGPAT5 Gene

Localization for AGPAT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGPAT5 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGPAT5 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 5
nucleus 4
cytosol 2
golgi apparatus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AGPAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA --
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with AGPAT5: view

Pathways & Interactions for AGPAT5 Gene

genes like me logo Genes that share pathways with AGPAT5: view

UniProtKB/Swiss-Prot Q9NUQ2-PLCE_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.

Gene Ontology (GO) - Biological Process for AGPAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006639 acylglycerol metabolic process IEA --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with AGPAT5: view

No data available for SIGNOR curated interactions for AGPAT5 Gene

Drugs & Compounds for AGPAT5 Gene

(2) Drugs for AGPAT5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0
Coenzyme A Nutra 0

(53) Additional Compounds for AGPAT5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with AGPAT5: view

Transcripts for AGPAT5 Gene

Unigene Clusters for AGPAT5 Gene

1-acylglycerol-3-phosphate O-acyltransferase 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4:
SP5: - - - - - -
SP6: - - - - - - - - - - - - -
SP7:
SP8:

Relevant External Links for AGPAT5 Gene

GeneLoc Exon Structure for
AGPAT5
ECgene alternative splicing isoforms for
AGPAT5

Expression for AGPAT5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AGPAT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AGPAT5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.7), Breast (11.3), and Blymphocyte (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AGPAT5 Gene



Protein tissue co-expression partners for AGPAT5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AGPAT5 Gene:

AGPAT5

SOURCE GeneReport for Unigene cluster for AGPAT5 Gene:

Hs.624002

mRNA Expression by UniProt/SwissProt for AGPAT5 Gene:

Q9NUQ2-PLCE_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with AGPAT5: view

Primer Products

No data available for mRNA differential expression in normal tissues for AGPAT5 Gene

Orthologs for AGPAT5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AGPAT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGPAT5 34 35
  • 98.9 (n)
dog
(Canis familiaris)
Mammalia AGPAT5 34 35
  • 87.61 (n)
cow
(Bos Taurus)
Mammalia AGPAT5 34 35
  • 87.01 (n)
mouse
(Mus musculus)
Mammalia Agpat5 34 16 35
  • 84.98 (n)
rat
(Rattus norvegicus)
Mammalia Agpat5 34
  • 83.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 78 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
-- 35
  • 36 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia AGPAT5 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGPAT5 34 35
  • 78.05 (n)
lizard
(Anolis carolinensis)
Reptilia AGPAT5 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agpat5 34
  • 70.71 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23241 34
zebrafish
(Danio rerio)
Actinopterygii agpat5 34 35
  • 65.38 (n)
worm
(Caenorhabditis elegans)
Secernentea acl-11 34 35
  • 47.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 18 (a)
ManyToMany
CST26 35
  • 16 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons LPAT4 34
  • 44.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4157 35
  • 40 (a)
OneToOne
Species where no ortholog for AGPAT5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGPAT5 Gene

ENSEMBL:
Gene Tree for AGPAT5 (if available)
TreeFam:
Gene Tree for AGPAT5 (if available)

Paralogs for AGPAT5 Gene

Paralogs for AGPAT5 Gene

Pseudogenes.org Pseudogenes for AGPAT5 Gene

genes like me logo Genes that share paralogs with AGPAT5: view

Variants for AGPAT5 Gene

Sequence variations from dbSNP and Humsavar for AGPAT5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10086543 -- 6,725,177(+) TTCTT(A/T)CTTGC intron-variant
rs10088817 -- 6,729,901(+) TATAT(C/T)TACCC intron-variant
rs10090110 -- 6,724,974(+) TTTTT(C/T)TACAG intron-variant
rs10091758 -- 6,721,230(+) CTGGT(A/G)ATATA intron-variant
rs10091854 -- 6,721,327(+) TTTAT(A/G)GCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGPAT5 Gene

Variant ID Type Subtype PubMed ID
nsv956055 CNV deletion 24416366
nsv831220 CNV gain 17160897
nsv819007 CNV gain 19587683
nsv610006 CNV gain 21841781
nsv610004 CNV gain 21841781
nsv6059 CNV insertion 18451855
nsv465436 CNV gain 19166990
nsv1073767 CNV deletion 25765185
nsv1031577 CNV gain 25217958
nsv1028963 CNV gain 25217958
nsv1025976 CNV loss 25217958
nsv1021684 CNV loss 25217958
esv992826 CNV deletion 20482838
esv7258 CNV loss 19470904
esv4888 CNV loss 18987735
esv3543004 CNV deletion 23714750
esv2736536 CNV deletion 23290073
esv2584030 CNV deletion 19546169
esv2546871 CNV deletion 19546169
esv2422383 CNV duplication 17116639
esv2145090 CNV deletion 18987734
dgv6878n100 CNV gain 25217958
dgv6877n100 CNV gain 25217958
dgv6876n100 CNV loss 25217958
dgv3757n106 CNV deletion 24896259

Variation tolerance for AGPAT5 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGPAT5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGPAT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGPAT5 Gene

Disorders for AGPAT5 Gene

Relevant External Links for AGPAT5

Genetic Association Database (GAD)
AGPAT5
Human Genome Epidemiology (HuGE) Navigator
AGPAT5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGPAT5

No disorders were found for AGPAT5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGPAT5 Gene

Publications for AGPAT5 Gene

  1. Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria. (PMID: 21173190) Prasad S.S. … Agarwal A.K. (J. Lipid Res. 2011) 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity. (PMID: 16620771) Agarwal A.K. … Garg A. (Arch. Biochem. Biophys. 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for AGPAT5 Gene

Sources for AGPAT5 Gene

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