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GIFtS

AGPAT5 Gene

protein-coding   GIFtS: 50
GCID: GC08P006554

1-acylglycerol-3-phosphate O-acyltransferase 5

(Previous names: 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic...)
  Search for AGPAT5
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Biological research products
for AGPAT5    

Aliases
for AGPAT5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
1-Acylglycerol-3-Phosphate O-Acyltransferase 51 2 3     FLJ112101
1-Acylglycerol-3-Phosphate O-Acyltransferase 5 (Lysophosphatidic Acid
Acyltransferase, Epsilon)1 2
     LPAAT-E1
LPAAT-Epsilon1     1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Epsilon2
Lysophosphatidic Acid Acyltransferase Epsilon2 3     1AGPAT52
1-AGP Acyltransferase 52 3     LPAATE2
1-AGPAT 52 3     EC 2.3.1.513

External Ids:    HGNC: 208861   Entrez Gene: 553262   Ensembl: ENSG000001551897   OMIM: 6147965   UniProtKB: Q9NUQ23   

Export aliases for AGPAT5 gene to outside databases

Previous GC identifer: GC08P006346


Summaries
for AGPAT5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AGPAT5:
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein
converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. (provided
by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PLCE_HUMAN, Q9NUQ2
Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2
position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1
position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not
arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward
lysophosphatidylglycerol not detectable

Gene Wiki entry for AGPAT5


Genomic Views
for AGPAT5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_023736.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AGPAT5 gene promoter:
         NF-1   NF-1/L   CBF-C   PPAR-gamma1   CBF-B   CBF-A   HFH-1   CP1A   PPAR-gamma2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AGPAT5 promoter sequence
   Search SABiosciences Chromatin IP Primers for AGPAT5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGPAT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

AGPAT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGPAT5 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P006554:  view genomic region     (about GC identifiers)

Start:
 6,565,878 bp from pter      End:
 6,619,024 bp from pter
Size:
 53,147 bases      Orientation:
 plus strand

Proteins
for AGPAT5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PLCE_HUMAN, Q9NUQ2 (See protein sequence)
Recommended Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon  
Size: 364 amino acids; 42072 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. Mitochondrion
Caution: It is uncertain whether Met-1 or Met-12 is the initiator
Sequence caution: Sequence=BAA92069.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q8IZ47 Q9BQG4

Explore the universe of human proteins at neXtProt for AGPAT5: NX_Q9NUQ2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NUQ2

    • AGPAT5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060831.2  
    ENSEMBL proteins: 
     ENSP00000285518   ENSP00000430016   ENSP00000430751   ENSP00000428152  
    Reactome Protein details: Q9NUQ2
    Human Recombinant Protein Products: 
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    Uscn Proteins for AGPAT5

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IEA--
    GO:0005739mitochondrion IDA--
    GO:0005741mitochondrial outer membrane TAS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--


    AGPAT5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for AGPAT5

    Protein Domains /
    Families
    for AGPAT5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AGPAT5 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002123 Plipid/glycerol_acylTrfase

    Graphical View of Domain Structure for InterPro Entry Q9NUQ2

    ProtoNet protein and cluster: Q9NUQ2

    1 Blocks protein family: IPB002123 Phospholipid/glycerol acyltransferase

    UniProtKB/Swiss-Prot: PLCE_HUMAN, Q9NUQ2
    Domain: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the
    phosphate moiety of the glycerol-3-phosphate (By similarity)
    Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


    Function
    for AGPAT5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PLCE_HUMAN, Q9NUQ2
    Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2
    position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1
    position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not
    arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward
    lysophosphatidylglycerol not detectable
    Catalytic activity: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
    Biophysicochemical properties: Kinetic parameters: KM=5.52 uM for LPA sn-1 C18:1; KM=16.30 uM for C18:1-CoA; Vmax=2.42
    nmol/min/mg enzyme toward LPA sn-1 C18:1; Vmax=1.22 nmol/min/mg enzyme toward C18:1-CoA;

    Enzyme Number (IUBMB): EC 2.3.1.511

    miRNA
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    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate AGPAT5 (see all 35):
    hsa-miR-3607-3p hsa-miR-507 hsa-miR-124 hsa-miR-186 hsa-miR-506 hsa-miR-2113 hsa-miR-433 hsa-miR-3065-3p
    SwitchGear 3'UTR luciferase reporter plasmid: AGPAT5 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: AGPAT5
    OriGene siRNA: AGPAT5
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity NAS15367102


    AGPAT5 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Agpat5):
     liver/biliary system 

    AGPAT5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for AGPAT5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1CDP-diacylglycerol biosynthesis I
    		CDP-diacylglycerol biosynthesis I1.00
    		triacylglycerol biosynthesis0.50
    		phosphatidylglycerol biosynthesis II (non-plastidic)0.94
    		Triacylglyceride Synthesis0.17
    2Glycerophospholipid biosynthesis
    		Glycerophospholipid biosynthesis1.00
    		Phospholipid metabolism0.64
    3Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    4Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52
    5Fatty Acyl-CoA Biosynthesis
    		Triglyceride Biosynthesis0.47

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4 BioSystems Pathways for AGPAT5 
        Triacylglyceride Synthesis
    CDP-diacylglycerol biosynthesis I
    triacylglycerol biosynthesis
    phosphatidylglycerol biosynthesis II (non-plastidic)

    5/7        Reactome Pathways for AGPAT5 (see all 7)
        Glycerophospholipid biosynthesis
    Synthesis of PA
    Metabolism
    Phospholipid metabolism
    Triglyceride Biosynthesis


    UniProtKB/Swiss-Prot: PLCE_HUMAN, Q9NUQ2
    Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate:
    step 2/3


    AGPAT5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AGPAT5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/21 Interacting proteins for AGPAT5 (Q9NUQ23 ENSP000002855184) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    YWHABP319463I2D: score=1 
    AGPAT6ENSP000003801844STRING: ENSP00000380184
    AGPAT9ENSP000002644094STRING: ENSP00000264409
    GPAMENSP000002652764STRING: ENSP00000265276
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006639acylglycerol metabolic process ----
    GO:0006644phospholipid metabolic process TAS--
    GO:0006654phosphatidic acid biosynthetic process TAS--
    GO:0008654phospholipid biosynthetic process NAS15367102
    GO:0016024CDP-diacylglycerol biosynthetic process IEA--


    AGPAT5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AGPAT5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AGPAT5

    10/54 HMDB Compounds for AGPAT5 (see all 54)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--
    Search CenterWatch for drugs/clinical trials and news about AGPAT5 / PLCE 

    Transcripts
    for AGPAT5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AGPAT5 gene: 
    NM_018361.3  

    Unigene Cluster for AGPAT5:

    1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
    Hs.624002  [show with all ESTs]
    Unigene Representative Sequence: BX640918
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285518(uc003wqo.3 uc011kwm.2) ENST00000523234 ENST00000518327
    ENST00000523586 ENST00000530716 ENST00000533648 ENST00000533159

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    hsa-miR-3607-3p hsa-miR-507 hsa-miR-124 hsa-miR-186 hsa-miR-506 hsa-miR-2113 hsa-miR-433 hsa-miR-3065-3p
    SwitchGear 3'UTR luciferase reporter plasmid: AGPAT5 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF375789.1 AK002072.1 AK021722.1 AK310545.1 AL136587.1 BC023550.2 BC068519.1 BC080537.1 
    BX640918.1 

    14 DOTS entries:

    DT.95349851  DT.316041  DT.306525  DT.100811041  DT.40244974  DT.121490401  DT.92435308  DT.203159 
    DT.100711717  DT.100790389  DT.100790395  DT.92435309  DT.99971749  DT.99956327 

    24/290 AceView cDNA sequences (see all 290):

    CB266566 AW573205 BP369569 CB306609 CA414711 BQ000072 BX491999 BI062995 
    BQ722875 CR624453 AA280082 BE502708 AA872805 BI062977 CB045740 BU429366 
    CF993793 AL546290 BX116466 BC068519 AI699310 AW518021 AA516130 BC023550 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT5 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c
    SP1:                          -     -           -                                   -                                                   
    SP2:                          -     -           -                       -     -     -     -     -     -                                 
    SP3:                          -     -     -     -                                   -                                                   
    SP4:                                                                                                                                    
    SP5:                                                                    -     -     -     -     -     -                                 


    ECgene alternative splicing isoforms for AGPAT5

    Expression
    for AGPAT5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AGPAT5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTTTATGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See AGPAT5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AGPAT5

    SOURCE GeneReport for Unigene cluster: Hs.624002

    UniProtKB/Swiss-Prot: PLCE_HUMAN, Q9NUQ2
    Tissue specificity: Widely expressed

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    In Situ
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    Orthologs
    for AGPAT5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for AGPAT5 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Agpat51 , 5 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic more1, 5 84.98(n)1
    82.14(a)1    		   8 (10.30 cM)5
    521231  NM_026792.31  NP_081068.11 
     188462775 
    chicken
    (Gallus gallus)    		 Aves AGPAT51 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic more 78.05(n)
    77.69(a)    		   421898  XM_419916.3  XP_419916.1 
    lizard
    (Anolis carolinensis)    		 Reptilia AGPAT56
    		 --
    		 72(a)
    		 1 ↔ 1
    		 1(151922767-151953742)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.232412 Xenopus laevis transcribed sequence with moderate similarity more 75.69(n)    BX842842.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii agpat51 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic more 65.37(n)
    69.17(a)    		   767778  NM_001076745.1  NP_001070213.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea acl-111 Protein ACL-11 48.31(n)
    34.75(a)    		   185044  NM_059078.2  NP_491479.2 


    ENSEMBL Gene Tree for AGPAT5 (if available)
    TreeFam Gene Tree for AGPAT5 (if available) 

    Paralogs
    for AGPAT5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AGPAT5 gene
    LCLAT12  AGPAT42  AGPAT32  

    AGPAT5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for AGPAT5
    PGOHUM00000233891


    Genomic Variants
    for AGPAT5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/148 NCBI SNPs in AGPAT5 are shown (see all 148)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs15597431,2
    		F,O,--6356991(+) TGCAAG/CCATCC 1 -- int12Minor allele frequency- C:0.04WA NA 238
    rs15597451,2
    		C,F,A,H,--6357309(+) TAATTA/GCCTAA 1 -- int120Minor allele frequency- G:0.07NS EA NA WA 2144
    rs134394951,2
    		C,F,A,H,--6357352(+) GAATTG/CCACTA 1 -- int114Minor allele frequency- C:0.04NS EA NA WA 1672
    rs20191881,2
    		H--6357539(+) TATCAG/TGATTT 1 -- int14Minor allele frequency- T:0.00NS EA 420
    rs757457111,2
    		--6357664(+) TTTACA/TTTAGG 1 -- int12Minor allele frequency- T:0.09CSA WA 120
    rs735249381,2
    		C,F,--6357709(+) GTTCAG/ATTAGT 1 -- int13Minor allele frequency- A:0.12WA 122
    rs735249391,2
    		C,F,--6357809(+) TAGTAG/AGCAGG 1 -- int13Minor allele frequency- A:0.12WA 122
    rs778138101,2
    		--6358261(+) TGACGA/TAAATG 1 -- int11Minor allele frequency- T:0.01EA 120
    rs780421531,2
    		F,--6358282(+) AGTCAA/GTGCAA 1 -- int11Minor allele frequency- G:0.03EA 120
    rs175738201,2
    		C,F,--6358398(+) CAGTGG/CTTGGG 1 -- int14Minor allele frequency- C:0.03NA 262

    HapMap Linkage Disequilibrium report for AGPAT5 (6565878 - 6619024 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for AGPAT5
         2 CNVs: 5250 95190
         5 Indels: 100260 42201 59486 47569 62774

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    Disorders / Diseases
    for AGPAT5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AGPAT5 for disorders           About MalaCards

    AGPAT5 for disorders           About GeneDecksing

    OMIM gene information: 614796    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: AGPAT5 (2 documents)

    Export disorders for AGPAT5 gene to outside databases

    Publications
    for AGPAT5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AGPAT5 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with AGPAT5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria. (PubMed id 21173190)1, 2 Prasad S.S....Agarwal A.K. (2011)
    2. Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity. (PubMed id 16620771)1, 2 Agarwal A.K....Garg A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)

    External Searches for AGPAT5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing AGPAT5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55326 HGNC: 20886 AceView: LPAAT-e Ensembl:ENSG00000155189 euGenes: HUgn55326
    ECgene: AGPAT5 H-InvDB: AGPAT5

    Other Databases showing AGPAT5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AGPAT5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AGPAT5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for AGPAT5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AGPAT5 gene:
    Search GeneIP for patents involving AGPAT5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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