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AGPAT5 Gene

protein-coding   GIFtS: 56
GCID: GC08P006554

1-Acylglycerol-3-Phosphate O-Acyltransferase 5

(Previous names: 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic...)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
1-Acylglycerol-3-Phosphate O-Acyltransferase 51 2 3     Lysophosphatidic Acid Acyltransferase1
1-Acylglycerol-3-Phosphate O-Acyltransferase 5 (Lysophosphatidic Acid
Acyltransferase, Epsilon)1 2
     1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Epsilon2
Lysophosphatidic Acid Acyltransferase Epsilon2 3     1AGPAT52
1-AGP Acyltransferase 52 3     LPAATE2
1-AGPAT 52 3     EC 2.3.1.513
epsilon1     LPAAT-epsilon3

External Ids:    HGNC: 208861   Entrez Gene: 553262   Ensembl: ENSG000001551897   OMIM: 6147965   UniProtKB: Q9NUQ23   

Export aliases for AGPAT5 gene to outside databases

Previous GC identifer: GC08P006346


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AGPAT5 Gene:
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane
protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid
biosynthesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for AGPAT5 Gene:
AGPAT5 (1-acylglycerol-3-phosphate O-acyltransferase 5) is a protein-coding gene. Diseases associated with AGPAT5 include melanoma. GO annotations related to this gene include 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is LCLAT1.

UniProtKB/Swiss-Prot: PLCE_HUMAN, Q9NUQ2
Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2
position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the
sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but
not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward
lysophosphatidylglycerol not detectable

Gene Wiki entry for AGPAT5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_023736.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the AGPAT5 gene promoter:
         NF-1   NF-1/L   CBF-C   PPAR-gamma1   CBF-B   CBF-A   HFH-1   CP1A   PPAR-gamma2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAGPAT5 promoter sequence
   Search Chromatin IP Primers for AGPAT5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGPAT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

AGPAT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGPAT5 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P006554:  view genomic region     (about GC identifiers)

Start:
6,565,878 bp from pter      End:
6,619,024 bp from pter
Size:
53,147 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PLCE_HUMAN, Q9NUQ2 (See protein sequence)
Recommended Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon  
Size: 364 amino acids; 42072 Da
Caution: It is uncertain whether Met-1 or Met-12 is the initiator
Sequence caution: Sequence=BAA92069.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q8IZ47 Q9BQG4

Explore the universe of human proteins at neXtProt for AGPAT5: NX_Q9NUQ2

Explore proteomics data for AGPAT5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys183
  • Modification sites at PhosphoSitePlus

  • See AGPAT5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060831.2  
    ENSEMBL proteins: 
     ENSP00000285518   ENSP00000430016   ENSP00000430751   ENSP00000428152  
    Reactome Protein details: Q9NUQ2

    AGPAT5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AGPAT: 1-acylglycerol-3-phosphate O-acyltransferases

    1 InterPro protein domain:
     IPR002123 Plipid/glycerol_acylTrfase

    Graphical View of Domain Structure for InterPro Entry Q9NUQ2

    ProtoNet protein and cluster: Q9NUQ2

    1 Blocks protein domain: IPB002123 Phospholipid/glycerol acyltransferase

    UniProtKB/Swiss-Prot: PLCE_HUMAN, Q9NUQ2
    Domain: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the
    phosphate moiety of the glycerol-3-phosphate (By similarity)
    Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


    AGPAT5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLCE_HUMAN, Q9NUQ2
    Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2
    position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the
    sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but
    not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward
    lysophosphatidylglycerol not detectable
    Catalytic activity: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
    Biophysicochemical properties: Kinetic parameters: KM=5.52 uM for LPA sn-1 C18:1; KM=16.30 uM for C18:1-CoA;
    Vmax=2.42 nmol/min/mg enzyme toward LPA sn-1 C18:1; Vmax=1.22 nmol/min/mg enzyme toward C18:1-CoA;

         Enzyme Number (IUBMB): EC 2.3.1.511

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity NAS15367102
    GO:0016746transferase activity, transferring acyl groups ----
         
    AGPAT5 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Agpat5):
     liver/biliary system 

    AGPAT5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AGPAT5
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    Block miRNA regulation of human, mouse, rat AGPAT5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AGPAT5 (see all 35):
    hsa-miR-3607-3p hsa-miR-507 hsa-miR-124 hsa-miR-186 hsa-miR-506 hsa-miR-2113 hsa-miR-433 hsa-miR-3065-3p
    SwitchGear 3'UTR luciferase reporter plasmidAGPAT5 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLCE_HUMAN, Q9NUQ2: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion5
    nucleus5
    cytosol2
    golgi apparatus2
    extracellular1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IEA--
    GO:0005739mitochondrion IDA--
    GO:0005741mitochondrial outer membrane TAS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--

    AGPAT5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AGPAT5 About    
    See pathways by source

    SuperPathContained pathways About
    1triacylglycerol biosynthesis
    triacylglycerol biosynthesis0.48
    Triacylglyceride Synthesis0.36
    phosphatidylglycerol biosynthesis II (non-plastidic)0.48
    CDP-diacylglycerol biosynthesis I0.00
    2Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Synthesis of PA0.33
    Phospholipid metabolism0.64
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    4Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    5Triglyceride Biosynthesis
    Triglyceride Biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for AGPAT5
        CDP-diacylglycerol biosynthesis I
    Triacylglyceride Synthesis
    triacylglycerol biosynthesis
    phosphatidylglycerol biosynthesis II (non-plastidic)

    2 Reactome Pathways for AGPAT5
        Synthesis of PA
    Triglyceride Biosynthesis


    UniProtKB/Swiss-Prot: PLCE_HUMAN, Q9NUQ2
    Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol
    3-phosphate: step 2/3


    AGPAT5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AGPAT5
    Interactions:

        Search GeneGlobe Interaction Network for AGPAT5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AGPAT5 (Q9NUQ23 ENSP000002855184) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    YWHABP319463I2D: score=1 
    AGPAT6ENSP000003801844STRING: ENSP00000380184
    AGPAT9ENSP000002644094STRING: ENSP00000264409
    CDS2ENSP000004198794STRING: ENSP00000419879
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006639acylglycerol metabolic process ----
    GO:0006644phospholipid metabolic process TAS--
    GO:0006654phosphatidic acid biosynthetic process TAS--
    GO:0008152metabolic process ----
    GO:0008654phospholipid biosynthetic process NAS15367102

    AGPAT5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AGPAT5 (PLCE)

    Selected HMDB Compounds for AGPAT5 (see all 54)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AGPAT5 gene: 
    NM_018361.3  

    Unigene Cluster for AGPAT5:

    1-acylglycerol-3-phosphate O-acyltransferase 5
    Hs.624002  [show with all ESTs]
    Unigene Representative Sequence: BX640918
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285518(uc003wqo.3 uc011kwm.2) ENST00000523234 ENST00000518327
    ENST00000523586 ENST00000530716 ENST00000533648 ENST00000533159
    miRNA
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    hsa-miR-3607-3p hsa-miR-507 hsa-miR-124 hsa-miR-186 hsa-miR-506 hsa-miR-2113 hsa-miR-433 hsa-miR-3065-3p
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      QuantiTect SYBR Green Assays in human, mouse, rat AGPAT5
      QuantiFast Probe-based Assays in human, mouse, rat AGPAT5

    Additional mRNA sequence: 

    AF375789.1 AK002072.1 AK021722.1 AK310545.1 AL136587.1 BC023550.2 BC068519.1 BC080537.1 
    BX640918.1 

    14 DOTS entries:

    DT.95349851  DT.316041  DT.306525  DT.100811041  DT.40244974  DT.121490401  DT.92435308  DT.203159 
    DT.100711717  DT.100790389  DT.100790395  DT.92435309  DT.99971749  DT.99956327 

    Selected AceView cDNA sequences (see all 290):

    BQ000072 AA872805 BQ722875 CA431980 T32566 BU430723 Z40999 BQ013823 
    AA280082 CR611576 AU125154 CB306609 BX491999 BQ012904 CR608096 CD171783 
    AA234064 AA281331 CB157910 BU663418 AI920978 AA912691 AI300019 CR621552 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT5 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c
    SP1:                          -     -           -                                   -                                                   
    SP2:                          -     -           -                       -     -     -     -     -     -                                 
    SP3:                          -     -     -     -                                   -                                                   
    SP4:                                                                                                                                    
    SP5:                                                                    -     -     -     -     -     -                                 


    ECgene alternative splicing isoforms for AGPAT5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    AGPAT5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTTATGTT
    AGPAT5 Expression
    About this image


    AGPAT5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
    AGPAT5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AGPAT5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.624002

    UniProtKB/Swiss-Prot: PLCE_HUMAN, Q9NUQ2
    Tissue specificity: Widely expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AGPAT5 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agpat51 , 5 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic more1, 5 84.98(n)1
    82.14(a)1
      8 (10.30 cM)5
    521231  NM_026792.31  NP_081068.11 
     188462775 
    chicken
    (Gallus gallus)
    Aves AGPAT51 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic more 78.05(n)
    77.69(a)
      421898  XM_419916.4  XP_419916.1 
    lizard
    (Anolis carolinensis)
    Reptilia AGPAT56
    1-acylglycerol-3-phosphate O-acyltransferase 5
    71(a)
    1 ↔ 1
    1(151919229-151953742)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.232412 Xenopus laevis transcribed sequence with moderate similarity more 75.69(n)    BX842842.1 
    zebrafish
    (Danio rerio)
    Actinopterygii agpat51 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic more 65.38(n)
    69.06(a)
      767778  NM_001076745.2  NP_001070213.2 
    worm
    (Caenorhabditis elegans)
    Secernentea acl-111 acl-11 47.83(n)
    34.18(a)
      185044  NM_059078.3  NP_491479.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    CST266
    Probable membrane protein with three predicted tra...
    Protein required for incorporation of stearic acid...
    18(a)
    16(a)
    many ↔ many
    many ↔ many
    IV(482670-483860) YDR018C
    II(320416-321609) YBR042C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons LPAT41 LPAT4 44.23(n)
    30.07(a)
      843840  NM_106159.2  NP_565098.1 


    ENSEMBL Gene Tree for AGPAT5 (if available)
    TreeFam Gene Tree for AGPAT5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AGPAT5 gene
    LCLAT12  AGPAT42  AGPAT32  

    AGPAT5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for AGPAT5
    PGOHUM00000233891


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AGPAT5 (see all 1779)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1905500111,2
    --6769963(+) TCACTG/TTTCCA 1 -- us2k10--------
    rs1402153531,2
    --6770092(+) AGGAGA/GCAGAG 1 -- us2k10--------
    rs761141291,2
    F--6770131(+) TTGCAC/TGGAAA 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs344270991,2
    C--6770140(+) AAAGG-/AGAAAA 1 -- us2k10--------
    rs341358961,2
    C--6770141(+) AAGGG-/A/A   
       A
    /AGA
    AAAAA
    2 -- us2k1 cds10--------
    rs2010994361,2
    C--6770141(+) AAAGGA/GAAAAA 1 -- us2k10--------
    rs2002390041,2
    --6770143(+) GGGAA-/TAAAAA 1 -- us2k10--------
    rs1822276791,2
    --6770202(+) CTGTGA/GCTGTT 1 -- us2k10--------
    rs1836359171,2
    --6770215(+) CAGGAA/GGAGAG 1 -- us2k10--------
    rs1425144891,2
    --6770256(+) GTCAGA/GAGCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AGPAT5 (6565878 - 6619024 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AGPAT5 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv4888CNV Deletion18987735
    esv2736536CNV Deletion23290073
    esv2145090CNV Deletion18987734
    esv2584030CNV Deletion19546169
    esv992826CNV Deletion20482838
    esv2546871CNV Deletion19546169
    esv2422383CNV Duplication17116639
    nsv6059CNV Insertion18451855
    esv7258CNV Loss19470904
    nsv465436CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AGPAT5
    DNA2.0 Custom Variant and Variant Library Synthesis for AGPAT5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614796    OMIM disorders: --

    1 disease for AGPAT5:    
    About MalaCards
    melanoma


    AGPAT5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AGPAT5
    Human Genome Epidemiology (HuGE) Navigator: AGPAT5 (2 documents)

    Export disorders for AGPAT5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AGPAT5 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with AGPAT5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria. (PubMed id 21173190)1, 2 Prasad S.S.... Agarwal A.K. (J. Lipid Res. 2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity. (PubMed id 16620771)1, 2 Agarwal A.K.... Garg A. (Arch. Biochem. Biophys. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55326 HGNC: 20886 AceView: LPAAT-e Ensembl:ENSG00000155189 euGenes: HUgn55326
    ECgene: AGPAT5 H-InvDB: AGPAT5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AGPAT5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AGPAT5 gene:
    Search GeneIP for patents involving AGPAT5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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