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AGPAT4 Gene

protein-coding   GIFtS: 56
GCID: GC06M161471

1-Acylglycerol-3-Phosphate O-Acyltransferase 4

(Previous names: 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic...)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
1-Acylglycerol-3-Phosphate O-Acyltransferase 41 2 3     delta1
1-Acylglycerol-3-Phosphate O-Acyltransferase 4 (Lysophosphatidic Acid
Acyltransferase, Delta)1 2
     Lysophosphatidic Acid Acyltransferase1
Lysophosphatidic Acid Acyltransferase Delta2 3     1-AGPAT42
1-AGP Acyltransferase 42 3     1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Delta2
1-AGPAT 42 3     dJ473J16.22
LPAAT-delta2 3     Lysophosphatidic Acid Acyltransferase-Delta (LPAAT-Delta)2
EC 2.3.1.513 8     

External Ids:    HGNC: 208851   Entrez Gene: 568952   Ensembl: ENSG000000266527   OMIM: 6147955   UniProtKB: Q9NRZ53   

Export aliases for AGPAT4 gene to outside databases

Previous GC identifers: GC06M161466 GC06M161527 GC06M159006


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AGPAT4 Gene:
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane
protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid
biosynthesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for AGPAT4 Gene:
AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4) is a protein-coding gene. Diseases associated with AGPAT4 include prostatitis. GO annotations related to this gene include 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT5.

UniProtKB/Swiss-Prot: PLCD_HUMAN, Q9NRZ5
Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2
position of the glycerol backbone (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AGPAT4 gene promoter:
         TBP   AML1a   ATF-2   IRF-1   Gfi-1   AREB6   IRF-2   c-Jun   LyF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAGPAT4 promoter sequence
   Search Chromatin IP Primers for AGPAT4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGPAT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q26   Ensembl cytogenetic band:  6q26   HGNC cytogenetic band: 6q25.3

AGPAT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGPAT4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M161471:  view genomic region     (about GC identifiers)

Start:
161,551,011 bp from pter      End:
161,695,107 bp from pter
Size:
144,097 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PLCD_HUMAN, Q9NRZ5 (See protein sequence)
Recommended Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta  
Size: 378 amino acids; 44021 Da
Secondary accessions: Q5TEF0

Explore the universe of human proteins at neXtProt for AGPAT4: NX_Q9NRZ5

Explore proteomics data for AGPAT4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for AGPAT4 (Q9NRZ5) (see all 12)
     VPPRRPW  FEIDFLCGW  RTGTFPETP  SKVLAKKEL 


    See AGPAT4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_064518.1  
    ENSEMBL proteins: 
     ENSP00000314036   ENSP00000400211   ENSP00000413901   ENSP00000355872   ENSP00000407007  
     ENSP00000355878   ENSP00000355873   ENSP00000355875  
    Reactome Protein details: Q9NRZ5

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    Novus Biologicals AGPAT4 Lysates
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    Cloud-Clone Corp. CLIAs for AGPAT4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AGPAT: 1-acylglycerol-3-phosphate O-acyltransferases

    1 InterPro protein domain:
     IPR002123 Plipid/glycerol_acylTrfase

    Graphical View of Domain Structure for InterPro Entry Q9NRZ5

    ProtoNet protein and cluster: Q9NRZ5

    1 Blocks protein domain: IPB002123 Phospholipid/glycerol acyltransferase

    UniProtKB/Swiss-Prot: PLCD_HUMAN, Q9NRZ5
    Domain: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the
    phosphate moiety of the glycerol-3-phosphate (By similarity)
    Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


    AGPAT4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLCD_HUMAN, Q9NRZ5
    Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2
    position of the glycerol backbone (By similarity)
    Catalytic activity: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate

         Enzyme Number (IUBMB): EC 2.3.1.511 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity NAS15367102
    GO:0016746transferase activity, transferring acyl groups ----
         
    AGPAT4 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Agpat4 (no phenotypes)

    AGPAT4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Agpat4tm1Lex for AGPAT4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AGPAT4
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    hsa-mir-335-5p (MIRT018200), hsa-mir-877-3p (MIRT036864)

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    Selected qRT-PCR Assays for microRNAs that regulate AGPAT4 (see all 22):
    hsa-miR-3128 hsa-miR-623 hsa-miR-29a hsa-miR-29c hsa-miR-650 hsa-miR-204 hsa-miR-651 hsa-miR-3612
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLCD_HUMAN, Q9NRZ5: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    plasma membrane2
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--

    AGPAT4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AGPAT4 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    Synthesis of PA0.33
    2triacylglycerol biosynthesis
    triacylglycerol biosynthesis0.48
    Triacylglyceride Synthesis0.36
    phosphatidylglycerol biosynthesis II (non-plastidic)0.48
    CDP-diacylglycerol biosynthesis I0.00
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    4Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    5Triglyceride Biosynthesis
    Triglyceride Biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for AGPAT4
        CDP-diacylglycerol biosynthesis I
    Triacylglyceride Synthesis
    triacylglycerol biosynthesis
    phosphatidylglycerol biosynthesis II (non-plastidic)


    2 Reactome Pathways for AGPAT4
        Synthesis of PA
    Triglyceride Biosynthesis


    3 Kegg Pathways  (Kegg details for AGPAT4):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: PLCD_HUMAN, Q9NRZ5
    Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol
    3-phosphate: step 2/3


    AGPAT4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AGPAT4
    Interactions:

        Search GeneGlobe Interaction Network for AGPAT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AGPAT4 (Q9NRZ51, 3 ENSP000003140364) via UniProtKB, MINT, STRING, and/or I2D (see all 81)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461081, 3, ENSP000003005744EBI-1754287,EBI-886 I2D: score=1 STRING: ENSP00000300574
    CDS1Q929033, ENSP000002958874I2D: score=1 STRING: ENSP00000295887
    PHGDHO431753I2D: score=6 
    AP1S2P563773I2D: score=3 
    CSNK1G2P783683I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006654phosphatidic acid biosynthetic process TAS--
    GO:0008152metabolic process ----
    GO:0008654phospholipid biosynthetic process NAS15367102
    GO:0016024CDP-diacylglycerol biosynthetic process IEA--

    AGPAT4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AGPAT4 (PLCD)

    Selected HMDB Compounds for AGPAT4 (see all 55)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AGPAT4 gene (3 alternative transcripts): 
    NM_020133.2  NM_001012733.1  NM_001012734.1  

    Unigene Cluster for AGPAT4:

    1-acylglycerol-3-phosphate O-acyltransferase 4
    Hs.353175  [show with all ESTs]
    Unigene Representative Sequence: NM_020133
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000320285(uc003qtr.1 uc003qts.1 uc011egb.1) ENST00000437165
    ENST00000436279 ENST00000366905 ENST00000457520 ENST00000366911 ENST00000366906
    ENST00000366908(uc003qtt.1 uc011egc.1 uc011egd.1 uc011ege.1)

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    Selected qRT-PCR Assays for microRNAs that regulate AGPAT4 (see all 22):
    hsa-miR-3128 hsa-miR-623 hsa-miR-29a hsa-miR-29c hsa-miR-650 hsa-miR-204 hsa-miR-651 hsa-miR-3612
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    Additional mRNA sequence: 

    AF156776.1 AJ227890.1 AJ227891.1 AJ420473.1 AK074208.1 AK295025.1 AK295548.1 AK295826.1 
    AK297636.1 AK299721.1 AL122123.1 AY358506.1 BC013410.2 BC020209.1 

    15 DOTS entries:

    DT.441014  DT.40127164  DT.121395464  DT.95074563  DT.121395405  DT.70105317  DT.121395417  DT.95321105 
    DT.92419839  DT.100000566  DT.100683167  DT.100837161  DT.100814100  DT.121395439  DT.40123388 

    Selected AceView cDNA sequences (see all 153):

    AW081591 BX339407 BX952150 CR615061 BQ712742 BG681392 NM_020133 AI805207 
    CR615644 CR623504 NM_024929 AL537272 BC020209 CR609642 BP346854 AL122123 
    BP371275 BP349254 CR590247 AI921468 AK026765 CD364427 BM873830 AA588764 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT4 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
    SP1:                    -           -     -           -                                       
    SP2:                                                  -                                       
    SP3:                    -     -     -     -                                                   
    SP4:                    -                                                                     
    SP5:                    -           -     -                                                   


    ECgene alternative splicing isoforms for AGPAT4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AGPAT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTTAGTG
    AGPAT4 Expression
    About this image

    AGPAT4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AGPAT4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.353175

    UniProtKB/Swiss-Prot: PLCD_HUMAN, Q9NRZ5
    Tissue specificity: Widely expressed with highest levels in skeletal muscle, followed by heart, liver, prostate
    and thymus

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGPAT4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for AGPAT4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agpat41 , 5 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic more1, 5 83.69(n)1
    85.71(a)1
      17 (8.33 cM)5
    682621  NM_026644.21  NP_080920.21 
     121187045 
    chicken
    (Gallus gallus)
    Aves AGPAT41 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic more 75.64(n)
    78.4(a)
      421578  XM_004935560.1  XP_004935617.1 
    lizard
    (Anolis carolinensis)
    Reptilia AGPAT46
    1-acylglycerol-3-phosphate O-acyltransferase 4
    77(a)
    1 ↔ 1
    1(211611475-211663709)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.56952 Xenopus laevis transcribed sequence with moderate similarity more 78.39(n)    CA983176.1 
    zebrafish
    (Danio rerio)
    Actinopterygii map3k42 Danio rerio cDNA clone MGC63605 IMAGE5600467, complete more 74.59(n)    BC056788.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG47296
    CG47536
    --
    36(a)
    34(a)
    many ↔ many
    many ↔ many
    3L(16374872-16379057)
    3L(16372074-16374670)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CST26(YBR042C)4 Protein required for incorporation of stearic acid more   --   2(321609-320416) 852330  NP_009598.1 


    ENSEMBL Gene Tree for AGPAT4 (if available)
    TreeFam Gene Tree for AGPAT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AGPAT4 gene
    AGPAT52  LCLAT12  AGPAT32  
    2 SIMAP similar genes for AGPAT4 using alignment to 8 protein entries:     PLCD_HUMAN (see all proteins):
    DKFZp686G10113    AGPAT3

    AGPAT4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AGPAT4 (see all 3052)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs674058661,2
    C--159080104(+) TTTTT-/T/TTT 
            
    GAGAC
    1 -- int11NA 2
    rs1807077941,2
    --161550594(+) TACACC/TAATCT 1 -- ds50010--------
    rs1852813321,2
    --161550598(+) CTAATA/CTTCAT 1 -- ds50010--------
    rs1904329011,2
    --161550662(+) GACAGA/GCAGAT 1 -- ds50010--------
    rs1435151111,2
    C--161550709(+) CCTGGC/TCCCAC 1 -- ds50010--------
    rs1383973901,2
    --161550722(+) CCAGCA/GTTTTC 1 -- ds50010--------
    rs767065861,2
    C--161550740(+) CTGGTA/GAGAGA 1 -- ds50010--------
    rs1825983671,2
    --161550778(+) GTTCAA/GGCAAA 1 -- ds50010--------
    rs1470415421,2
    C--161550817(+) GAGAA-/AGAGAAT 1 -- ds50010--------
    rs790250531,2
    C,F--161550879(+) AGAGGC/TGGGGC 1 -- ds50011Minor allele frequency- T:0.08NA 120

    HapMap Linkage Disequilibrium report for AGPAT4 (161551011 - 161695107 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AGPAT4 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2733076CNV Deletion23290073
    esv2733074CNV Deletion23290073
    esv2659009CNV Deletion23128226
    esv2733075CNV Deletion23290073
    esv2311013CNV Deletion18987734
    esv1221310CNV Deletion17803354
    esv2733072CNV Deletion23290073
    nsv5574CNV Insertion18451855
    nsv507371CNV Insertion20534489
    nsv349803CNV Insertion16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AGPAT4
    DNA2.0 Custom Variant and Variant Library Synthesis for AGPAT4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614795    OMIM disorders: --

    1 disease for AGPAT4:    
    About MalaCards
    prostatitis


    AGPAT4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AGPAT4
    Human Genome Epidemiology (HuGE) Navigator: AGPAT4 (1 document)

    Export disorders for AGPAT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AGPAT4 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with AGPAT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. The structure and functions of human lysophosphatidic acid acyltransferases. (PubMed id 11487472)1, 2 Leung D.W. (Front. Biosci. 2001)
    6. Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria. (PubMed id 21173190)2 Prasad S.S.... Agarwal A.K. (J. Lipid Res. 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    9. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
    10. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (Proteomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56895 HGNC: 20885 AceView: AGPAT4 Ensembl:ENSG00000026652 euGenes: HUgn56895
    ECgene: AGPAT4 Kegg: 56895 H-InvDB: AGPAT4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AGPAT4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AGPAT4 gene:
    Search GeneIP for patents involving AGPAT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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