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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AGPAT4 Gene

protein-coding   GIFtS: 54
GCID: GC06M161471

1-acylglycerol-3-phosphate O-acyltransferase 4

(Previous names: 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic...)
  Search for AGPAT4
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Aliases
for AGPAT4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
1-Acylglycerol-3-Phosphate O-Acyltransferase 41 2 3     1-AGPAT 42 3
LPAAT-Delta1     EC 2.3.1.513 8
1-Acylglycerol-3-Phosphate O-Acyltransferase 4 (Lysophosphatidic Acid
Acyltransferase, Delta)1 2
     1-AGPAT42
DJ473J16.21     1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Delta2
Lysophosphatidic Acid Acyltransferase Delta2 3     Lysophosphatidic Acid Acyltransferase-Delta (LPAAT-Delta)2
1-AGP Acyltransferase 42 3     

External Ids:    HGNC: 208851   Entrez Gene: 568952   Ensembl: ENSG000000266527   OMIM: 6147955   UniProtKB: Q9NRZ53   

Export aliases for AGPAT4 gene to outside databases

Previous GC identifers: GC06M161466 GC06M161527 GC06M159006


Summaries
for AGPAT4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AGPAT4:
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein
converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. (provided
by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PLCD_HUMAN, Q9NRZ5
Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2
position of the glycerol backbone (By similarity)




Genomic Views
for AGPAT4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AGPAT4 gene promoter:
         TBP   AML1a   ATF-2   IRF-1   Gfi-1   AREB6   IRF-2   c-Jun   LyF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AGPAT4 promoter sequence
   Search SABiosciences Chromatin IP Primers for AGPAT4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGPAT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q26   Ensembl cytogenetic band:  6q26   HGNC cytogenetic band: 6q25.3

AGPAT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGPAT4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M161471:  view genomic region     (about GC identifiers)

Start:
 161,551,011 bp from pter      End:
 161,695,107 bp from pter
Size:
 144,097 bases      Orientation:
 minus strand

Proteins
for AGPAT4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PLCD_HUMAN, Q9NRZ5 (See protein sequence)
Recommended Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta  
Size: 378 amino acids; 44021 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q5TEF0

Explore the universe of human proteins at neXtProt for AGPAT4: NX_Q9NRZ5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NRZ5

    • 4/12 DME Specific Peptides for AGPAT4 (Q9NRZ5) (see all 12)
     VPPRRPW  FEIDFLCGW  RTGTFPETP  SKVLAKKEL 

    AGPAT4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_064518.1  
    ENSEMBL proteins: 
     ENSP00000314036   ENSP00000400211   ENSP00000413901   ENSP00000355872   ENSP00000407007  
     ENSP00000355878   ENSP00000355873   ENSP00000355875  
    Reactome Protein details: Q9NRZ5
    Human Recombinant Protein Products: 
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    Uscn Proteins for AGPAT4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--


    AGPAT4 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for AGPAT4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AGPAT4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002123 Plipid/glycerol_acylTrfase

    Graphical View of Domain Structure for InterPro Entry Q9NRZ5

    ProtoNet protein and cluster: Q9NRZ5

    1 Blocks protein family: IPB002123 Phospholipid/glycerol acyltransferase

    UniProtKB/Swiss-Prot: PLCD_HUMAN, Q9NRZ5
    Domain: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the
    phosphate moiety of the glycerol-3-phosphate (By similarity)
    Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


    Function
    for AGPAT4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PLCD_HUMAN, Q9NRZ5
    Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2
    position of the glycerol backbone (By similarity)
    Catalytic activity: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate

    Enzyme Number (IUBMB): EC 2.3.1.511 2

    miRNA
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate AGPAT4 (see all 22):
    hsa-miR-3128 hsa-miR-623 hsa-miR-29a hsa-miR-29c hsa-miR-650 hsa-miR-204 hsa-miR-651 hsa-miR-3612
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    OriGene shRNA RFP: AGPAT4
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity NAS15367102
    GO:0016746transferase activity, transferring acyl groups ----


    AGPAT4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Agpat4tm1Lex for AGPAT4
         1 MGI phenotypic allele for Agpat4 (no phenotypes)

    AGPAT4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for AGPAT4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1CDP-diacylglycerol biosynthesis I
    		CDP-diacylglycerol biosynthesis I1.00
    		triacylglycerol biosynthesis0.50
    		phosphatidylglycerol biosynthesis II (non-plastidic)0.94
    		Triacylglyceride Synthesis0.17
    2Glycerophospholipid biosynthesis
    		Glycerophospholipid biosynthesis1.00
    		Glycerophospholipid metabolism0.54
    		Phospholipid metabolism0.64
    3Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    		Metabolic pathways0.38
    4Glycerolipid metabolism
    		Glycerolipid metabolism1.00
    5Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4 BioSystems Pathways for AGPAT4 
        Triacylglyceride Synthesis
    CDP-diacylglycerol biosynthesis I
    phosphatidylglycerol biosynthesis II (non-plastidic)
    triacylglycerol biosynthesis

    5/7        Reactome Pathways for AGPAT4 (see all 7)
        Glycerophospholipid biosynthesis
    Synthesis of PA
    Metabolism
    Phospholipid metabolism
    Triglyceride Biosynthesis


    3         Kegg Pathways  (Kegg details for AGPAT4):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: PLCD_HUMAN, Q9NRZ5
    Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate:
    step 2/3


    AGPAT4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AGPAT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/55 Interacting proteins for AGPAT4 (Q9NRZ51, 3 ENSP000003140364) via UniProtKB, MINT, STRING, and/or I2D (see all 55)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461081, 3, ENSP000003005744EBI-1754287,EBI-886 I2D: score=1 STRING: ENSP00000300574
    CDS1Q929033, ENSP000002958874I2D: score=1 STRING: ENSP00000295887
    PHGDHO431753I2D: score=6 
    AP1S2P563773I2D: score=3 
    CSNK1G2P783683I2D: score=2 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006654phosphatidic acid biosynthetic process TAS--
    GO:0008654phospholipid biosynthetic process NAS15367102
    GO:0016024CDP-diacylglycerol biosynthetic process IEA--
    GO:0019432triglyceride biosynthetic process TAS--


    AGPAT4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AGPAT4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for AGPAT4

    10/55 HMDB Compounds for AGPAT4 (see all 55)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--
    Search CenterWatch for drugs/clinical trials and news about AGPAT4 / PLCD 

    Transcripts
    for AGPAT4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AGPAT4 gene (3 alternative transcripts): 
    NM_020133.2  NM_001012733.1  NM_001012734.1  

    Unigene Cluster for AGPAT4:

    1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
    Hs.353175  [show with all ESTs]
    Unigene Representative Sequence: NM_020133
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000320285(uc003qtr.1 uc003qts.1 uc011egb.1) ENST00000437165
    ENST00000436279 ENST00000366905 ENST00000457520 ENST00000366911 ENST00000366906
    ENST00000366908(uc003qtt.1 uc011egc.1 uc011egd.1 uc011ege.1)


    miRNA
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    Additional cDNA sequence: 

    AF156776.1 AJ227890.1 AJ227891.1 AJ420473.1 AK074208.1 AK295025.1 AK295548.1 AK295826.1 
    AK297636.1 AK299721.1 AL122123.1 AY358506.1 BC013410.2 BC020209.1 

    15 DOTS entries:

    DT.441014  DT.40127164  DT.121395464  DT.95074563  DT.121395405  DT.70105317  DT.121395417  DT.95321105 
    DT.92419839  DT.100000566  DT.100683167  DT.100837161  DT.100814100  DT.121395439  DT.40123388 

    24/153 AceView cDNA sequences (see all 153):

    BU623450 AL122123 AF156776 AI003974 CD364427 BM873830 AI805207 CR590247 
    BX339407 AA668688 AA588764 AI972548 BX333726 CR621965 AI537927 AL537272 
    AI928947 AU279996 AI652814 AK026765 BP346854 AI921468 BP371275 BQ072907 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT4 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
    SP1:                    -           -     -           -                                       
    SP2:                                                  -                                       
    SP3:                    -     -     -     -                                                   
    SP4:                    -                                                                     
    SP5:                    -           -     -                                                   


    ECgene alternative splicing isoforms for AGPAT4

    Expression
    for AGPAT4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AGPAT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCTTTAGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See AGPAT4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AGPAT4

    SOURCE GeneReport for Unigene cluster: Hs.353175

    UniProtKB/Swiss-Prot: PLCD_HUMAN, Q9NRZ5
    Tissue specificity: Widely expressed with highest levels in skeletal muscle, followed by heart, liver, prostate and
    thymus

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    In Situ
    Assay Products:     
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    Orthologs
    for AGPAT4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AGPAT4 gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves AGPAT41 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic more 76(n)
    79.2(a)    		   421578  XM_419616.3  XP_419616.2 
    lizard
    (Anolis carolinensis)    		 Reptilia AGPAT46
    		 --
    		 77(a)
    		 1 ↔ 1
    		 1(211611482-211663709)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.56952 Xenopus laevis transcribed sequence with moderate similarity more 78.39(n)    CA983176.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii map3k42 Danio rerio cDNA clone MGC63605 IMAGE5600467, complete more 74.59(n)    BC056788.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG47296
    CG47536
    		 --
    		 36(a)
    34(a)
    		 many ↔ many
    many ↔ many
    		 3L(16374872-16379057)
    3L(16372074-16374670)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes CST26(YBR042C)4
    YDR018C1    		 Protein required for incorporation of stearic acid more4
    hypothetical protein1    		 41.34(n)1
    31.18(a)1    		   2(321609-320416)4
    8515811  NP_010301.11  8523304 
     NP_009598.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons LPAT36
    LPAT26
    		 lysophosphatidyl acyltransferase 2
    		 31(a)
    28(a)
    		 many ↔ many
    many ↔ many
    		 1(19003376-19005641)
    3(21349507-21353174)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 acyltransferase, putative, expressed
    		 32(a)
    		 1 → many
    		 11(24733671-24739878)


    ENSEMBL Gene Tree for AGPAT4 (if available)
    TreeFam Gene Tree for AGPAT4 (if available) 

    Paralogs
    for AGPAT4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AGPAT4 gene
    AGPAT52  LCLAT12  AGPAT32  
    2 SIMAP similar genes for AGPAT4 using alignment to 8 protein entries:     PLCD_HUMAN (see all proteins):
    DKFZp686G10113    AGPAT3

    AGPAT4 for paralogs           About GeneDecksing



    Genomic Variants
    for AGPAT4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2576 NCBI SNPs in AGPAT4 are shown (see all 2576)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1807077941,2
    		--161550594(+) TACACC/TAATCT 1 -- ds50010--------
    rs1852813321,2
    		--161550598(+) CTAATA/CTTCAT 1 -- ds50010--------
    rs1904329011,2
    		--161550662(+) GACAGA/GCAGAT 1 -- ds50010--------
    rs1435151111,2
    		--161550709(+) CCTGGC/TCCCAC 1 -- ds50010--------
    rs1383973901,2
    		--161550722(+) CCAGCA/GTTTTC 1 -- ds50010--------
    rs767065861,2
    		C,--161550740(+) CTGGTA/GAGAGA 1 -- ds50010--------
    rs1825983671,2
    		--161550778(+) GTTCAA/GGCAAA 1 -- ds50010--------
    rs1470415421,2
    		C,--161550817(+) GAGAA-/AGAGAAT 1 -- ds50010--------
    rs790250531,2
    		C,F,--161550879(+) AGAGGC/TGGGGC 1 -- ds50011Minor allele frequency- T:0.08NA 120
    rs1868126971,2
    		--161550880(+) GAGGCA/GGGGCA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for AGPAT4 (161551011 - 161695107 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for AGPAT4
         3 CNVs: 7543 8531 64699
         6 Indels: 81690 28149 47039 94153 81689 40943

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    Disorders / Diseases
    for AGPAT4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AGPAT4 for disorders           About MalaCards

    AGPAT4 for disorders           About GeneDecksing

    OMIM gene information: 614795    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: AGPAT4 (1 document)

    Export disorders for AGPAT4 gene to outside databases

    Publications
    for AGPAT4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AGPAT4 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with AGPAT4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. The structure and functions of human lysophosphatidic acid acyltransferases. (PubMed id 11487472)1, 2 Leung D.W. (2001)
    5. Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria. (PubMed id 21173190)2 Prasad S.S....Agarwal A.K. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
    10. Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart. (PubMed id 15367102)1 Lu B....Choy P.C. (2005)

    External Searches for AGPAT4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing AGPAT4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56895 HGNC: 20885 AceView: AGPAT4 Ensembl:ENSG00000026652 euGenes: HUgn56895
    ECgene: AGPAT4 Kegg: 56895 H-InvDB: AGPAT4

    Other Databases showing AGPAT4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AGPAT4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AGPAT4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for AGPAT4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AGPAT4 gene:
    Search GeneIP for patents involving AGPAT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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