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Aliases for AGPAT4 Gene

Aliases for AGPAT4 Gene

  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 4 2 3 4
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 4 (Lysophosphatidic Acid Acyltransferase, Delta) 2 3
  • Lysophosphatidic Acid Acyltransferase Delta 3 4
  • 1-AGP Acyltransferase 4 3 4
  • LPAAT-Delta 3 4
  • EC 2.3.1.51 4 64
  • 1-AGPAT 4 3 4
  • Lysophosphatidic Acid Acyltransferase-Delta (LPAAT-Delta) 3
  • 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Delta 3
  • Lysophosphatidic Acid Acyltransferase 2
  • DJ473J16.2 3
  • 1-AGPAT4 3
  • Delta 2

External Ids for AGPAT4 Gene

Summaries for AGPAT4 Gene

Entrez Gene Summary for AGPAT4 Gene

  • This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGPAT4 Gene

AGPAT4 (1-Acylglycerol-3-Phosphate O-Acyltransferase 4) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT3.

UniProtKB/Swiss-Prot for AGPAT4 Gene

  • Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGPAT4 Gene

Genomics for AGPAT4 Gene

Genomic Location for AGPAT4 Gene

Start:
161,129,979 bp from pter
End:
161,274,075 bp from pter
Size:
144,097 bases
Orientation:
Minus strand

Genomic View for AGPAT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGPAT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGPAT4 Gene

Regulatory Elements for AGPAT4 Gene

Proteins for AGPAT4 Gene

  • Protein details for AGPAT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRZ5-PLCD_HUMAN
    Recommended name:
    1-acyl-sn-glycerol-3-phosphate acyltransferase delta
    Protein Accession:
    Q9NRZ5
    Secondary Accessions:
    • B4DSF9
    • Q5TEF0

    Protein attributes for AGPAT4 Gene

    Size:
    378 amino acids
    Molecular mass:
    44021 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AGPAT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGPAT4 Gene

Proteomics data for AGPAT4 Gene at MOPED

Post-translational modifications for AGPAT4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGPAT4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for AGPAT4 Gene

Gene Families for AGPAT4 Gene

HGNC:
  • AGPAT :1-acylglycerol-3-phosphate O-acyltransferases

Protein Domains for AGPAT4 Gene

UniProtKB/Swiss-Prot:

PLCD_HUMAN
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.:
    • Q9NRZ5
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.:
    • Q9NRZ5
genes like me logo Genes that share domains with AGPAT4: view

Function for AGPAT4 Gene

Molecular function for AGPAT4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
UniProtKB/Swiss-Prot Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.

Enzyme Numbers (IUBMB) for AGPAT4 Gene

Gene Ontology (GO) - Molecular Function for AGPAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity NAS 15367102
GO:0005515 protein binding IPI 25416956
GO:0016746 transferase activity, transferring acyl groups --
genes like me logo Genes that share ontologies with AGPAT4: view

miRNA for AGPAT4 Gene

miRTarBase miRNAs that target AGPAT4

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AGPAT4 Gene

Localization for AGPAT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGPAT4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGPAT4 Gene COMPARTMENTS Subcellular localization image for AGPAT4 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 2
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AGPAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AGPAT4: view

Pathways for AGPAT4 Gene

genes like me logo Genes that share pathways with AGPAT4: view

UniProtKB/Swiss-Prot Q9NRZ5-PLCD_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3

Gene Ontology (GO) - Biological Process for AGPAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0008152 metabolic process --
GO:0008654 phospholipid biosynthetic process NAS 15367102
GO:0016024 CDP-diacylglycerol biosynthetic process IEA --
genes like me logo Genes that share ontologies with AGPAT4: view

Compounds for AGPAT4 Gene

(55) HMDB Compounds for AGPAT4 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with AGPAT4: view

Transcripts for AGPAT4 Gene

Unigene Clusters for AGPAT4 Gene

1-acylglycerol-3-phosphate O-acyltransferase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - - - -
SP2: -
SP3: - - - -
SP4: -
SP5: - - -
SP6:
SP7:

Relevant External Links for AGPAT4 Gene

GeneLoc Exon Structure for
AGPAT4
ECgene alternative splicing isoforms for
AGPAT4

Expression for AGPAT4 Gene

mRNA expression in normal human tissues for AGPAT4 Gene

mRNA differential expression in normal tissues according to GTEx for AGPAT4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGPAT4 Gene

SOURCE GeneReport for Unigene cluster for AGPAT4 Gene Hs.353175

mRNA Expression by UniProt/SwissProt for AGPAT4 Gene

Q9NRZ5-PLCD_HUMAN
Tissue specificity: Widely expressed with highest levels in skeletal muscle, followed by heart, liver, prostate and thymus.
genes like me logo Genes that share expressions with AGPAT4: view

Orthologs for AGPAT4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AGPAT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGPAT4 36
  • 98.32 (n)
  • 98.42 (a)
AGPAT4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AGPAT4 36
  • 86.6 (n)
  • 89.15 (a)
AGPAT4 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGPAT4 36
  • 88.18 (n)
  • 92.06 (a)
AGPAT4 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agpat4 36
  • 83.69 (n)
  • 85.71 (a)
Agpat4 16
Agpat4 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGPAT4 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGPAT4 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agpat4 36
  • 84.13 (n)
  • 85.71 (a)
chicken
(Gallus gallus)
Aves AGPAT4 36
  • 75.64 (n)
  • 78.4 (a)
AGPAT4 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGPAT4 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5695 36
tropical clawed frog
(Silurana tropicalis)
Amphibia agpat4 36
  • 71.38 (n)
  • 76.53 (a)
zebrafish
(Danio rerio)
Actinopterygii agpat4 36
  • 66.76 (n)
  • 67.9 (a)
agpat4 37
  • 68 (a)
OneToOne
map3k4 36
fruit fly
(Drosophila melanogaster)
Insecta CG4729 37
  • 36 (a)
ManyToMany
CG4753 37
  • 34 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 18 (a)
ManyToMany
CST26 37
  • 19 (a)
ManyToMany
CST26 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 26 (a)
ManyToMany
-- 37
  • 33 (a)
ManyToMany
Species with no ortholog for AGPAT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGPAT4 Gene

ENSEMBL:
Gene Tree for AGPAT4 (if available)
TreeFam:
Gene Tree for AGPAT4 (if available)

Paralogs for AGPAT4 Gene

Paralogs for AGPAT4 Gene

Selected SIMAP similar genes for AGPAT4 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with AGPAT4: view

Variants for AGPAT4 Gene

Sequence variations from dbSNP and Humsavar for AGPAT4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs453493 -- 161,256,649(+) AGAGA(C/T)GGCGT intron-variant
rs729986 -- 161,165,808(-) TGATC(A/G)TTGAA intron-variant, upstream-variant-2KB
rs733766 -- 161,209,931(-) AAAAC(A/G)AAACG intron-variant
rs746731 -- 161,188,757(-) CTCCC(C/T)AAGCT intron-variant
rs747866 -- 161,271,254(-) GTGTC(C/T)TAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGPAT4 Gene

Variant ID Type Subtype PubMed ID
nsv886817 CNV Gain 21882294
nsv526643 CNV Loss 19592680
nsv527098 CNV Loss 19592680
esv2659009 CNV Deletion 23128226
esv27949 CNV Loss 19812545
esv2733072 CNV Deletion 23290073
nsv528938 CNV Loss 19592680
esv2752091 CNV Gain 17911159
nsv5574 CNV Insertion 18451855
esv33824 CNV Gain+Loss 17666407
nsv5575 CNV Loss 18451855
nsv886818 CNV Gain 21882294
nsv520807 CNV Loss 19592680
esv272350 CNV Insertion 20981092
esv2733074 CNV Deletion 23290073
esv2311013 CNV Deletion 18987734
esv2733075 CNV Deletion 23290073
esv1221310 CNV Deletion 17803354
nsv349803 CNV Insertion 16902084
esv2733076 CNV Deletion 23290073
nsv507371 CNV Insertion 20534489

Relevant External Links for AGPAT4 Gene

HapMap Linkage Disequilibrium report
AGPAT4

Disorders for AGPAT4 Gene

Relevant External Links for AGPAT4

Genetic Association Database (GAD)
AGPAT4
Human Genome Epidemiology (HuGE) Navigator
AGPAT4
genes like me logo Genes that share disorders with AGPAT4: view

No data available for UniProtKB/Swiss-Prot for AGPAT4 Gene

Publications for AGPAT4 Gene

  1. The structure and functions of human lysophosphatidic acid acyltransferases. (PMID: 11487472) Leung D.W. (Front. Biosci. 2001) 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for AGPAT4 Gene

Sources for AGPAT4 Gene

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