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AGPAT3 Gene

protein-coding   GIFtS: 60
GCID: GC21P045285

1-Acylglycerol-3-Phosphate O-Acyltransferase 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
1-Acylglycerol-3-Phosphate O-Acyltransferase 31 2 3     Gene Similar To Plant Lysophosphatidic Acid Acyltransferase11
LPAAT32 3 5     1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Gamma2
Lysophosphatidic Acid Acyltransferase Gamma2 3     LPAAT-GAMMA12
1-AGP Acyltransferase 32 3     Lysophosphatidic Acid Acyltransferase-Gamma12
1-AGPAT 32 3     LPAAT-gamma3
EC 2.3.1.513 8     

External Ids:    HGNC: 3261   Entrez Gene: 568942   Ensembl: ENSG000001602167   OMIM: 6147945   UniProtKB: Q9NRZ73   

Export aliases for AGPAT3 gene to outside databases

Previous GC identifers: GC21P041812 GC21M041877 GC21P044141 GC21P044109 GC21P030692


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AGPAT3 Gene:
The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid,
which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral
membrane protein. Two transcript variants encoding the same protein have been found for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for AGPAT3 Gene:
AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3) is a protein-coding gene. GO annotations related to this gene include 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT5.

UniProtKB/Swiss-Prot: PLCC_HUMAN, Q9NRZ7
Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2
position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the
sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine,
lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA

Gene Wiki entry for AGPAT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AGPAT3 gene promoter:
         COUP-TF1   Pax-5   ATF-2   COUP   Lmo2   CUTL1   CRE-BP1   COUP-TF   Sox9   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAGPAT3 promoter sequence

   Search Chromatin IP Primers for AGPAT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AGPAT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
AGPAT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGPAT3 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P045285:   GeneLoc Nature:405,311-319
Start:
45,285,067 bp from pter       30,833,164 bp from centromere
End:
45,407,475 bp from pter 30,911,690 bp from centromere
Size:
122,409 bases 78,527 bases
Orientation:
plus strand plus strand

genomic clones: P24J14 to KB218C10


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PLCC_HUMAN, Q9NRZ7 (See protein sequence)
Recommended Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma  
Size: 376 amino acids; 43381 Da
Secondary accessions: D3DSL2 Q3ZCU2 Q6UWP6 Q6ZUC6 Q8N3Q7 Q9NRZ6
Alternative splicing: 3 isoforms:  Q9NRZ7-1   Q9NRZ7-2   Q9NRZ7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AGPAT3: NX_Q9NRZ7

Explore proteomics data for AGPAT3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys119, Lys201, Lys236
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for AGPAT3 (Q9NRZ7)
     SKVLAKKEL  FEIDFLCGW  SQLVMLLEWWS  WLHKLYQEKDA 


    See AGPAT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001032642.1  NP_064517.1  

    ENSEMBL proteins: 
     ENSP00000291572   ENSP00000389318   ENSP00000381138   ENSP00000332989   ENSP00000412079  
     ENSP00000381140   ENSP00000381135   ENSP00000413906   ENSP00000394102   ENSP00000414440  
     ENSP00000443510  
    Reactome Protein details: Q9NRZ7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AGPAT: 1-acylglycerol-3-phosphate O-acyltransferases

    1 InterPro protein domain:
     IPR002123 Plipid/glycerol_acylTrfase

    Graphical View of Domain Structure for InterPro Entry Q9NRZ7

    ProtoNet protein and cluster: Q9NRZ7

    1 Blocks protein domain: IPB002123 Phospholipid/glycerol acyltransferase

    UniProtKB/Swiss-Prot: PLCC_HUMAN, Q9NRZ7
    Domain: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the
    phosphate moiety of the glycerol-3-phosphate (By similarity)
    Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


    Find genes that share domains with AGPAT3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLCC_HUMAN, Q9NRZ7
    Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2
    position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the
    sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine,
    lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA
    Catalytic activity: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
    Biophysicochemical properties: Kinetic parameters: KM=4.78 uM for LPA sn-1 C18:1; KM=21.53 uM for C18:1-CoA;
    Vmax=6.35 nmol/min/mg enzyme toward LPA sn-1 C18:1; Vmax=0.74 nmol/min/mg enzyme toward C18:1-CoA;

         Enzyme Number (IUBMB): EC 2.3.1.511 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity NAS15367102
    GO:0016746transferase activity, transferring acyl groups ----
         
    Find genes that share ontologies with AGPAT3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for AGPAT3:
     Decreased number of cells in m 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Agpat3):
     mortality/aging 

    Find genes that share phenotypes with AGPAT3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for AGPAT3

    miRNA
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    miRTarBase miRNAs that target AGPAT3:
    hsa-mir-744-5p (MIRT016086), hsa-mir-24-3p (MIRT030467), hsa-mir-26b-5p (MIRT029038), hsa-mir-149-5p (MIRT045627), hsa-mir-18a-3p (MIRT040936), hsa-mir-100-5p (MIRT048576), hsa-mir-335-5p (MIRT017029)

    Block miRNA regulation of human, mouse, rat AGPAT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AGPAT3 (see all 66):
    hsa-miR-100* hsa-miR-193a-3p hsa-miR-300 hsa-miR-15a hsa-miR-128 hsa-miR-219-5p hsa-miR-3613-3p hsa-miR-508-5p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLCC_HUMAN, Q9NRZ7: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    plasma membrane5
    golgi apparatus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IEA--
    GO:0005783endoplasmic reticulum IDA16780588
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005886plasma membrane IDA16780588
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with AGPAT3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AGPAT3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    Synthesis of PA0.33
    2triacylglycerol biosynthesis
    triacylglycerol biosynthesis0.48
    Triacylglyceride Synthesis0.36
    phosphatidylglycerol biosynthesis II (non-plastidic)0.48
    CDP-diacylglycerol biosynthesis I0.00
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    4Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    5Triglyceride Biosynthesis
    Triglyceride Biosynthesis


    Find genes that share SuperPaths with AGPAT3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for AGPAT3
        CDP-diacylglycerol biosynthesis I
    Triacylglyceride Synthesis
    triacylglycerol biosynthesis
    phosphatidylglycerol biosynthesis II (non-plastidic)


    2 Reactome Pathways for AGPAT3
        Synthesis of PA
    Triglyceride Biosynthesis


    3 Kegg Pathways  (Kegg details for AGPAT3):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: PLCC_HUMAN, Q9NRZ7
    Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol
    3-phosphate: step 2/3

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AGPAT3
    Interactions:

        Search GeneGlobe Interaction Network for AGPAT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AGPAT3 (Q9NRZ73 ENSP000002915724) via UniProtKB, MINT, STRING, and/or I2D (see all 59)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    AGPAT6ENSP000003801844STRING: ENSP00000380184
    AGPAT9ENSP000002644094STRING: ENSP00000264409
    CDS1ENSP000002958874STRING: ENSP00000295887
    CDS2ENSP000004198794STRING: ENSP00000419879
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    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006654phosphatidic acid biosynthetic process TAS--
    GO:0008152metabolic process ----
    GO:0008654phospholipid biosynthetic process NAS15367102
    GO:0016024CDP-diacylglycerol biosynthetic process IEA--

    Find genes that share ontologies with AGPAT3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for AGPAT3 (PLCC)

    Selected HMDB Compounds for AGPAT3 (see all 55)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AGPAT3 gene (2 alternative transcripts): 
    NM_001037553.1  NM_020132.4  

    Unigene Cluster for AGPAT3:

    1-acylglycerol-3-phosphate O-acyltransferase 3
    Hs.248785  [show with all ESTs]
    Unigene Representative Sequence: NM_020132
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291572(uc002zdv.3 uc002zdx.3 uc002zdy.3) ENST00000474735
    ENST00000448287 ENST00000398061 ENST00000327505 ENST00000445582 ENST00000398063(uc002zdw.3)
    ENST00000398058 ENST00000457068 ENST00000448845 ENST00000498670 ENST00000422850
    ENST00000497909 ENST00000479117 ENST00000481319 ENST00000467358 ENST00000484865
    ENST00000546158
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    Additional mRNA sequence: 

    AB040138.1 AF156774.1 AF156775.1 AK026135.1 AK074300.1 AK300562.1 AL109795.1 AL355720.1 
    AL355721.1 AL832919.1 AY358704.1 BC004219.2 BC004413.1 BC011971.1 BC013167.1 BC026047.1 
    BC040603.1 BC063552.1 

    19 DOTS entries:

    DT.214160  DT.95246787  DT.95077931  DT.75166854  DT.101976234  DT.95246774  DT.100785922  DT.91972317 
    DT.121134668  DT.91981388  DT.92447777  DT.100704498  DT.92447772  DT.92447773  DT.95246750  DT.121134673 
    DT.91898473  DT.92447775  DT.100799335 

    Selected AceView cDNA sequences (see all 442):

    AL109795 BQ707673 BU622423 AI640829 AA777475 BM683605 NM_020132 BU196613 
    AV659333 AW016215 BE218362 AA595222 BX325280 H05200 BC040603 BM783941 
    BU733106 BQ231526 AI985491 BC063552 BQ640134 AA369745 AI823782 BM666454 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AGPAT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AGPAT3 Expression
    About this image


    AGPAT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Kidney (Urinary System)
             Metanephros
     
     Thymus (Hematopoietic System)
             Thymus
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Bone (Muscoskeletal System)
             Zeugopod Epiphyseal End
     
     Neural Tube (Nervous System)
             Metencephalon
    AGPAT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AGPAT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248785

    UniProtKB/Swiss-Prot: PLCC_HUMAN, Q9NRZ7
    Tissue specificity: Widely expressed with highest levels in testis, pancreas and kidney, followed by spleen, lung,
    adipose tissue and liver

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AGPAT3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Agpat31 , 5 1-acylglycerol-3-phosphate O-acyltransferase 31, 5 86.08(n)1
    92.29(a)1
      10 (39.72 cM)5
    281691  NM_053014.31  NP_443747.21 
     782691785 
    chicken
    (Gallus gallus)
    Aves AGPAT31 1-acylglycerol-3-phosphate O-acyltransferase 3 78.19(n)
    88.56(a)
      418550  XM_004934599.1  XP_004934656.1 
    lizard
    (Anolis carolinensis)
    Reptilia AGPAT36
    1-acylglycerol-3-phosphate O-acyltransferase 3
    88(a)
    1 ↔ 1
    3(136471240-136591481)
    African clawed frog
    (Xenopus laevis)
    Amphibia agpat3-prov2 1-acylglycerol-3-phosphate O-acyltransferase 3 75.5(n)    BC043776.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.248502 Danio rerio mRNA similar to 1-acylglycerol-3-phosphate more 75.18(n)    BC049474.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG47533
    CG47291
    1-acylglycerol-3-phosphate
    O-acyltransferase3
    CG47291
    37(a)3
    54.18(n)1
    41.24(a)1
      72E43
    398201  NM_001259864.11  NP_001246793.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    CST266
    Probable membrane protein with three predicted tra...
    Protein required for incorporation of stearic acid...
    18(a)
    18(a)
    many ↔ many
    many ↔ many
    IV(482670-483860) YDR018C
    II(320416-321609) YBR042C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons LPAT21 LPAT2 47.35(n)
    38.41(a)
      824934  NM_115625.3  NP_567052.1 


    ENSEMBL Gene Tree for AGPAT3 (if available)
    TreeFam Gene Tree for AGPAT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AGPAT3 gene
    AGPAT52  LCLAT12  AGPAT42  
    2 SIMAP similar genes for AGPAT3 using alignment to 6 protein entries:     PLCC_HUMAN (see all proteins):
    AGPAT4    DKFZp686G10113

    Find genes that share paralogs with AGPAT3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AGPAT3 (see all 2755)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs713340191,2
    C--30693282(+) AAAAATATT/-  
            
    TATTT
    1 -- int11Minor allele frequency- -:0.50NA 2
    rs20140851,2
    C,F,A--45283214(+) caccgC/Tgcctg 1 -- us2k112Minor allele frequency- T:0.48NA WA CSA EA 374
    rs1439832991,2
    C--45283227(+) CATTT-/TTT   
       GTTTG
    TTTGT
    1 -- us2k10--------
    rs787221541,2
    F--45283437(+) CAGGCC/TTCCTG 1 -- us2k10--------
    rs1874167271,2
    --45283551(+) GGTGAA/GAGGTT 1 -- us2k10--------
    rs1395093471,2
    --45283577(+) TCCACA/GAGCTT 1 -- us2k10--------
    rs100846231,2
    C,F,H--45283670(+) GTATTT/CTCTGA 1 -- us2k1 tfbs35Minor allele frequency- C:0.05NS WA 908
    rs1451540491,2
    C--45283806(+) AACACC/TGTGAG 1 -- us2k10--------
    rs559394431,2
    C,F--45283832(+) AAAAAA/TTTTTT 1 -- us2k13Minor allele frequency- T:0.24WA NA EA 358
    rs356698511,2
    C--45283833(+) AAAAAT/ATTTTT 1 -- us2k11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for AGPAT3 (45285067 - 45407475 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AGPAT3 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2723626CNV Deletion23290073
    esv2723625CNV Deletion23290073
    esv2723623CNV Deletion23290073
    esv2723624CNV Deletion23290073
    nsv913889CNV Loss21882294
    nsv913887CNV Loss21882294
    nsv834108CNV Loss17160897
    esv29710CNV Loss19812545
    nsv834107CNV Loss17160897
    nsv3538CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AGPAT3
    DNA2.0 Custom Variant and Variant Library Synthesis for AGPAT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614794    OMIM disorders: --


    Find genes that share disorders with AGPAT3           About GenesLikeMe

    Genetic Association Database (GAD): AGPAT3
    Human Genome Epidemiology (HuGE) Navigator: AGPAT3 (1 document)

    Export disorders for AGPAT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AGPAT3 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with AGPAT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria. (PubMed id 21173190)1, 2 Prasad S.S.... Agarwal A.K. (J. Lipid Res. 2011)
    2. Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. (PubMed id 21829377)1, 4 Lemaitre R.N....Steffen L.M. (PLoS Genet. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Membrane topology of human AGPAT3 (LPAAT3). (PubMed id 20537980)1, 2 Schmidt J.A.... Brown W.J. (Biochem. Biophys. Res. Commun. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. The structure and functions of human lysophosphatidic acid acyltransferases. (PubMed id 11487472)1, 2 Leung D.W. (Front. Biosci. 2001)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56894 HGNC: 326 AceView: AGPAT3 Ensembl:ENSG00000160216 euGenes: HUgn56894
    ECgene: AGPAT3 Kegg: 56894 H-InvDB: AGPAT3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AGPAT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AGPAT3 gene:
    Search GeneIP for patents involving AGPAT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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