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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AGPAT3 Gene

protein-coding   GIFtS: 56
GCID: GC21P045285

1-acylglycerol-3-phosphate O-acyltransferase 3
 Explore 1 disease affiliated with
AGPAT3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AGPAT3    

Aliases
for AGPAT3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
Aliases
1-Acylglycerol-3-Phosphate O-Acyltransferase 31 2 3     EC 2.3.1.513 8
LPAAT-Gamma1     Gene Similar To Plant Lysophosphatidic Acid Acyltransferase11
Lysophosphatidic Acid Acyltransferase Gamma2 3     1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Gamma2
1-AGP Acyltransferase 32 3     LPAAT-GAMMA12
1-AGPAT 32 3     Lysophosphatidic Acid Acyltransferase-Gamma12
LPAAT32 3     

External Ids:    HGNC: 3261   Entrez Gene: 568942   Ensembl: ENSG000001602167   OMIM: 6147945   UniProtKB: Q9NRZ73   

Export aliases for AGPAT3 gene to outside databases

Previous GC identifers: GC21P041812 GC21M041877 GC21P044141 GC21P044109 GC21P030692


Summaries
for AGPAT3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AGPAT3:
The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid,
which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral
membrane protein. Two transcript variants encoding the same protein have been found for this gene. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PLCC_HUMAN, Q9NRZ7
Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2
position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1
position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine,
lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA

Gene Wiki entry for AGPAT3


Genomic Views
for AGPAT3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011515.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AGPAT3 gene promoter:
         COUP-TF1   Pax-5   ATF-2   COUP   Lmo2   CUTL1   CRE-BP1   COUP-TF   Sox9   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AGPAT3 promoter sequence

   Search SABiosciences Chromatin IP Primers for AGPAT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AGPAT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
AGPAT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AGPAT3 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P045285:   GeneLoc Nature:405,311-319
Start:
 45,285,067 bp from pter       30,833,164 bp from centromere
End:
 45,407,475 bp from pter 30,911,690 bp from centromere
Size:
 122,409 bases 78,527 bases
Orientation:
 plus strand plus strand

genomic clones: P24J14 to KB218C10

Proteins
for AGPAT3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PLCC_HUMAN, Q9NRZ7 (See protein sequence)
Recommended Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma  
Size: 376 amino acids; 43381 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope
Secondary accessions: D3DSL2 Q3ZCU2 Q6UWP6 Q6ZUC6 Q8N3Q7 Q9NRZ6
Alternative splicing: 3 isoforms:  Q9NRZ7-1   Q9NRZ7-2   Q9NRZ7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AGPAT3: NX_Q9NRZ7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NRZ7

    • 4 DME Specific Peptides for AGPAT3 (Q9NRZ7)
     SKVLAKKEL  FEIDFLCGW  SQLVMLLEWWS  WLHKLYQEKDA 

    AGPAT3 Protein expression data from MOPED and PaxDb:    About this image 
    AGPAT3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001032642.1  NP_064517.1  

    ENSEMBL proteins: 
     ENSP00000291572   ENSP00000389318   ENSP00000381138   ENSP00000332989   ENSP00000412079  
     ENSP00000381140   ENSP00000381135   ENSP00000413906   ENSP00000394102   ENSP00000414440  
     ENSP00000443510  
    Reactome Protein details: Q9NRZ7
    Human Recombinant Protein Products for AGPAT3: 
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    Novus Biologicals AGPAT3 Proteins
    Novus Biologicals AGPAT3 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for AGPAT3

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IEA--
    GO:0005783endoplasmic reticulum IDA16780588
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005886plasma membrane IDA16780588
    GO:0016021integral to membrane IEA--

    AGPAT3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for AGPAT3

    Protein Domains /
    Families
    for AGPAT3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AGPAT3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002123 Plipid/glycerol_acylTrfase

    Graphical View of Domain Structure for InterPro Entry Q9NRZ7

    ProtoNet protein and cluster: Q9NRZ7

    1 Blocks protein family: IPB002123 Phospholipid/glycerol acyltransferase

    UniProtKB/Swiss-Prot: PLCC_HUMAN, Q9NRZ7
    Domain: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the
    phosphate moiety of the glycerol-3-phosphate (By similarity)
    Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


    Function
    for AGPAT3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLCC_HUMAN, Q9NRZ7
    Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2
    position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1
    position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine,
    lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA
    Catalytic activity: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
    Biophysicochemical properties: Kinetic parameters: KM=4.78 uM for LPA sn-1 C18:1; KM=21.53 uM for C18:1-CoA; Vmax=6.35
    nmol/min/mg enzyme toward LPA sn-1 C18:1; Vmax=0.74 nmol/min/mg enzyme toward C18:1-CoA;

         Enzyme Number (IUBMB): EC 2.3.1.511 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity NAS15367102
    GO:0016746transferase activity, transferring acyl groups ----
         
    AGPAT3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AGPAT3:
     Decreased number of cells in m 

         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Agpat3):
     mortality/aging 

    AGPAT3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for AGPAT3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AGPAT3
    8/66 QIAGEN miScript miRNA Assays for microRNAs that regulate AGPAT3 (see all 66):
    hsa-miR-100* hsa-miR-193a-3p hsa-miR-300 hsa-miR-15a hsa-miR-128 hsa-miR-219-5p hsa-miR-3613-3p hsa-miR-508-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AGPAT3 (see all 7)
    OriGene shRNA RFP: AGPAT3
    OriGene siRNA: AGPAT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AGPAT3
    Sirion Biotech Custom design and validation of potent shRNA sequences against AGPAT3 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of AGPAT3 
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AGPAT3


    Pathways & Interactions
    for AGPAT3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1CDP-diacylglycerol biosynthesis I
    		CDP-diacylglycerol biosynthesis I1.00
    		triacylglycerol biosynthesis0.50
    		phosphatidylglycerol biosynthesis II (non-plastidic)0.94
    		Triacylglyceride Synthesis0.17
    2Glycerophospholipid biosynthesis
    		Glycerophospholipid biosynthesis1.00
    		Glycerophospholipid metabolism0.54
    		Phospholipid metabolism0.64
    3Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    		Metabolic pathways0.38
    4Glycerolipid metabolism
    		Glycerolipid metabolism1.00
    5Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4 BioSystems Pathways for AGPAT3 
        CDP-diacylglycerol biosynthesis I
    Triacylglyceride Synthesis
    triacylglycerol biosynthesis
    phosphatidylglycerol biosynthesis II (non-plastidic)

    5/7        Reactome Pathways for AGPAT3 (see all 7)
        Glycerophospholipid biosynthesis
    Synthesis of PA
    Metabolism
    Phospholipid metabolism
    Triglyceride Biosynthesis


    3         Kegg Pathways  (Kegg details for AGPAT3):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: PLCC_HUMAN, Q9NRZ7
    Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate:
    step 2/3


    AGPAT3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AGPAT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for AGPAT3 (Q9NRZ73 ENSP000002915724) via UniProtKB, MINT, STRING, and/or I2D (see all 33)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    AGPAT6ENSP000003801844STRING: ENSP00000380184
    AGPAT9ENSP000002644094STRING: ENSP00000264409
    GPAMENSP000002652764STRING: ENSP00000265276
    GPAT2ENSP000003525474STRING: ENSP00000352547
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006654phosphatidic acid biosynthetic process TAS--
    GO:0008654phospholipid biosynthetic process NAS15367102
    GO:0016024CDP-diacylglycerol biosynthetic process IEA--
    GO:0019432triglyceride biosynthetic process TAS--

    AGPAT3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AGPAT3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AGPAT3

    10/55 HMDB Compounds for AGPAT3 (see all 55)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--
    Search CenterWatch for drugs/clinical trials and news about AGPAT3 / PLCC 

    Transcripts
    for AGPAT3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AGPAT3 gene (2 alternative transcripts): 
    NM_001037553.1  NM_020132.4  

    Unigene Cluster for AGPAT3:

    1-acylglycerol-3-phosphate O-acyltransferase 3
    Hs.248785  [show with all ESTs]
    Unigene Representative Sequence: NM_020132
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000291572(uc002zdv.3 uc002zdx.3 uc002zdy.3) ENST00000474735
    ENST00000448287 ENST00000398061 ENST00000327505 ENST00000445582 ENST00000547109
    ENST00000398063(uc002zdw.3) ENST00000398058 ENST00000457068 ENST00000448845
    ENST00000498670 ENST00000422850 ENST00000497909 ENST00000479117 ENST00000481319
    ENST00000467358 ENST00000484865

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    hsa-miR-100* hsa-miR-193a-3p hsa-miR-300 hsa-miR-15a hsa-miR-128 hsa-miR-219-5p hsa-miR-3613-3p hsa-miR-508-5p
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB040138.1 AF156774.1 AF156775.1 AK026135.1 AK074300.1 AK300562.1 AL109795.1 AL355720.1 
    AL355721.1 AL832919.1 AY358704.1 BC004219.2 BC004413.1 BC011971.1 BC013167.1 BC026047.1 
    BC040603.1 BC063552.1 

    19 DOTS entries:

    DT.214160  DT.95246787  DT.95077931  DT.75166854  DT.101976234  DT.95246774  DT.100785922  DT.91972317 
    DT.121134668  DT.91981388  DT.92447777  DT.100704498  DT.92447772  DT.92447773  DT.95246750  DT.121134673 
    DT.91898473  DT.92447775  DT.100799335 

    24/442 AceView cDNA sequences (see all 442):

    BF590062 BM683605 AI091751 CD364521 AB040138 BM455810 BM459459 AI961857 
    F30855 AA369745 AA777475 BU429278 Z39755 BQ027200 BU619923 AA595222 
    CA950032 BM771979 AW614447 AI565184 BF447596 AL109795 BQ640134 BQ638021 

    GeneLoc Exon Structure


    Expression
    for AGPAT3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AGPAT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    AGPAT3 Expression
    About this image

    AGPAT3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See AGPAT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AGPAT3

    SOURCE GeneReport for Unigene cluster: Hs.248785

    UniProtKB/Swiss-Prot: PLCC_HUMAN, Q9NRZ7
    Tissue specificity: Widely expressed with highest levels in testis, pancreas and kidney, followed by spleen, lung,
    adipose tissue and liver

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    Orthologs
    for AGPAT3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AGPAT3 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves AGPAT31 1-acylglycerol-3-phosphate O-acyltransferase 3 78.19(n)
    88.56(a)    		   418550  XM_416756.3  XP_416756.2 
    lizard
    (Anolis carolinensis)    		 Reptilia AGPAT36
    		 --
    		 87(a)
    		 1 ↔ 1
    		 3(136471240-136494885)
    African clawed frog
    (Xenopus laevis)    		 Amphibia agpat3-prov2 1-acylglycerol-3-phosphate O-acyltransferase 3 75.5(n)    BC043776.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.248502 Danio rerio mRNA similar to 1-acylglycerol-3-phosphate more 75.18(n)    BC049474.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG47533
    CG47291    		 1-acylglycerol-3-phosphate
    O-acyltransferase3
    CG47291    		 37(a)3
    54.18(n)1
    41.24(a)1    		   72E43
    398201  NM_168662.21  NP_730161.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons LPAT21 lysophosphatidyl acyltransferase 2 46.71(n)
    38.27(a)    		   824934  NM_115625.3  NP_567052.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    		 acyltransferase, putative, expressed
    		 34(a)
    		 1 → many
    		 11(24733671-24739878)


    ENSEMBL Gene Tree for AGPAT3 (if available)
    TreeFam Gene Tree for AGPAT3 (if available) 

    Paralogs
    for AGPAT3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AGPAT3 gene
    AGPAT52  LCLAT12  AGPAT42  
    2 SIMAP similar genes for AGPAT3 using alignment to 6 protein entries:     PLCC_HUMAN (see all proteins):
    AGPAT4    DKFZp686G10113

    AGPAT3 for paralogs           About GeneDecksing



    Genomic Variants
    for AGPAT3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2247 NCBI SNPs in AGPAT3 are shown (see all 2247)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs20140851,2
    		C,F,A--45283214(+) CACCGC/TGCCTG 1 -- us2k112Minor allele frequency- T:0.48NA WA CSA EA 374
    rs1439832991,2
    		--45283227(+) CATTT-/TTT   
       GTTTG    TTTGT     		1 -- us2k10--------
    rs787221541,2
    		--45283437(+) CAGGCC/TTCCTG 1 -- us2k10--------
    rs1874167271,2
    		--45283551(+) GGTGAA/GAGGTT 1 -- us2k10--------
    rs1395093471,2
    		--45283577(+) TCCACA/GAGCTT 1 -- us2k10--------
    rs100846231,2
    		C,F,H--45283670(+) GTATTT/CTCTGA 1 -- us2k1 tfbs35Minor allele frequency- C:0.05NS WA 908
    rs1451540491,2
    		--45283806(+) AACACC/TGTGAG 1 -- us2k10--------
    rs559394431,2
    		C,F--45283832(+) AAAAAA/TTTTTT 1 -- us2k13Minor allele frequency- T:0.24WA NA EA 358
    rs356698511,2
    		C--45283833(+) AAAAAT/ATTTTT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1909567481,2
    		--45283834(+) AAAATA/TTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AGPAT3 (45285067 - 45407475 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 12 variations for AGPAT3
         7 CNVs: 90821 67803 90819 90822 5162 79382 7327
         5 Indels: 90824 79381 79383 90823 90820

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    Disorders / Diseases
    for AGPAT3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AGPAT3 for disorders           About GeneDecksing

    OMIM gene information: 614794    OMIM disorders: --

    1 disease for AGPAT3:    About MalaCards
    retinitis

    Human Genome Epidemiology (HuGE) Navigator: AGPAT3 (1 document)

    Export disorders for AGPAT3 gene to outside databases

    Publications
    for AGPAT3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AGPAT3 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with AGPAT3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria. (PubMed id 21173190)1, 2 Prasad S.S....Agarwal A.K. (2011)
    2. Membrane topology of human AGPAT3 (LPAAT3). (PubMed id 20537980)1, 2 Schmidt J.A....Brown W.J. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. The structure and functions of human lysophosphatidic acid acyltransferases. (PubMed id 11487472)1, 2 Leung D.W. (2001)
    7. Genetic loci associated with plasma phospholipid n-3 f atty acids: a meta-analysis of genome-wide association studies from the CHARGE C onsortium. (PubMed id 21829377)1 Lemaitre R.N....Steffen L.M. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    External Searches for AGPAT3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing AGPAT3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56894 HGNC: 326 AceView: AGPAT3 Ensembl:ENSG00000160216 euGenes: HUgn56894
    ECgene: AGPAT3 Kegg: 56894 H-InvDB: AGPAT3

    Other Databases showing AGPAT3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AGPAT3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AGPAT3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for AGPAT3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AGPAT3 gene:
    Search GeneIP for patents involving AGPAT3

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