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Aliases for AGPAT3 Gene

Aliases for AGPAT3 Gene

  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 3 2 3 4
  • LPAAT3 3 4 6
  • Lysophosphatidic Acid Acyltransferase Gamma 3 4
  • 1-AGP Acyltransferase 3 3 4
  • EC 2.3.1.51 4 63
  • 1-AGPAT 3 3 4
  • 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Gamma 3
  • Lysophosphatidic Acid Acyltransferase-Gamma1 3
  • LPAAT-GAMMA1 3
  • LPAAT-Gamma 4

External Ids for AGPAT3 Gene

Previous GeneCards Identifiers for AGPAT3 Gene

  • GC21P041812
  • GC21M041877
  • GC21P044141
  • GC21P044109
  • GC21P045285
  • GC21P030692

Summaries for AGPAT3 Gene

Entrez Gene Summary for AGPAT3 Gene

  • The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGPAT3 Gene

AGPAT3 (1-Acylglycerol-3-Phosphate O-Acyltransferase 3) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is LCLAT1.

UniProtKB/Swiss-Prot for AGPAT3 Gene

  • Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity).

Gene Wiki entry for AGPAT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGPAT3 Gene

Genomics for AGPAT3 Gene

Regulatory Elements for AGPAT3 Gene

Genomic Location for AGPAT3 Gene

Start:
43,865,149 bp from pter
End:
43,987,594 bp from pter
Size:
122,446 bases
Orientation:
Plus strand

Genomic View for AGPAT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGPAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGPAT3 Gene

Proteins for AGPAT3 Gene

  • Protein details for AGPAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRZ7-PLCC_HUMAN
    Recommended name:
    1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
    Protein Accession:
    Q9NRZ7
    Secondary Accessions:
    • D3DSL2
    • Q3ZCU2
    • Q6UWP6
    • Q6ZUC6
    • Q8N3Q7
    • Q9NRZ6

    Protein attributes for AGPAT3 Gene

    Size:
    376 amino acids
    Molecular mass:
    43381 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AGPAT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGPAT3 Gene

Proteomics data for AGPAT3 Gene at MOPED

Selected DME Specific Peptides for AGPAT3 Gene

Post-translational modifications for AGPAT3 Gene

  • Ubiquitination at Lys119, Lys201, and Lys236
  • Modification sites at PhosphoSitePlus

Domains for AGPAT3 Gene

Gene Families for AGPAT3 Gene

HGNC:
  • AGPAT :1-acylglycerol-3-phosphate O-acyltransferases

Protein Domains for AGPAT3 Gene

Suggested Antigen Peptide Sequences for AGPAT3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NRZ7

UniProtKB/Swiss-Prot:

PLCC_HUMAN :
  • Q9NRZ7
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with AGPAT3: view

Function for AGPAT3 Gene

Molecular function for AGPAT3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=4.78 uM for LPA sn-1 C18:1 {ECO:0000269 PubMed:21173190}; KM=21.53 uM for C18:1-CoA {ECO:0000269 PubMed:21173190}; Vmax=6.35 nmol/min/mg enzyme toward LPA sn-1 C18:1 {ECO:0000269 PubMed:21173190}; Vmax=0.74 nmol/min/mg enzyme toward C18:1-CoA {ECO:0000269 PubMed:21173190};
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
UniProtKB/Swiss-Prot Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity).

Enzyme Numbers (IUBMB) for AGPAT3 Gene

Gene Ontology (GO) - Molecular Function for AGPAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity NAS 15367102
GO:0016746 transferase activity, transferring acyl groups --
genes like me logo Genes that share ontologies with AGPAT3: view

Phenotypes for AGPAT3 Gene

genes like me logo Genes that share phenotypes with AGPAT3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGPAT3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for AGPAT3 Gene

Localization for AGPAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGPAT3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGPAT3 Gene COMPARTMENTS Subcellular localization image for AGPAT3 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
plasma membrane 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for AGPAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005635 nuclear envelope IEA --
GO:0005783 endoplasmic reticulum IDA 16780588
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane IDA 16780588
genes like me logo Genes that share ontologies with AGPAT3: view

Pathways for AGPAT3 Gene

genes like me logo Genes that share pathways with AGPAT3: view

UniProtKB/Swiss-Prot Q9NRZ7-PLCC_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3

Interacting Proteins for AGPAT3 Gene

Gene Ontology (GO) - Biological Process for AGPAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0008152 metabolic process --
GO:0008654 phospholipid biosynthetic process NAS 15367102
GO:0016024 CDP-diacylglycerol biosynthetic process IEA --
genes like me logo Genes that share ontologies with AGPAT3: view

Compounds for AGPAT3 Gene

(55) HMDB Compounds for AGPAT3 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with AGPAT3: view

Transcripts for AGPAT3 Gene

Unigene Clusters for AGPAT3 Gene

1-acylglycerol-3-phosphate O-acyltransferase 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AGPAT3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT3 Gene

No ASD Table

Relevant External Links for AGPAT3 Gene

GeneLoc Exon Structure for
AGPAT3
ECgene alternative splicing isoforms for
AGPAT3

Expression for AGPAT3 Gene

mRNA expression in normal human tissues for AGPAT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGPAT3 Gene

SOURCE GeneReport for Unigene cluster for AGPAT3 Gene Hs.248785

mRNA Expression by UniProt/SwissProt for AGPAT3 Gene

Q9NRZ7-PLCC_HUMAN
Tissue specificity: Widely expressed with highest levels in testis, pancreas and kidney, followed by spleen, lung, adipose tissue and liver.
genes like me logo Genes that share expressions with AGPAT3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for AGPAT3 Gene

Orthologs for AGPAT3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AGPAT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGPAT3 35
  • 98.76 (n)
  • 99.47 (a)
AGPAT3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AGPAT3 35
  • 88.21 (n)
  • 93.09 (a)
AGPAT3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGPAT3 35
  • 87.77 (n)
  • 92.53 (a)
AGPAT3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agpat3 35
  • 86.08 (n)
  • 92.29 (a)
Agpat3 16
Agpat3 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AGPAT3 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGPAT3 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agpat3 35
  • 85.64 (n)
  • 91.76 (a)
chicken
(Gallus gallus)
Aves AGPAT3 35
  • 78.19 (n)
  • 88.56 (a)
AGPAT3 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGPAT3 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia agpat3-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia agpat3 35
  • 75.2 (n)
  • 81.33 (a)
Str.11652 35
zebrafish
(Danio rerio)
Actinopterygii agpat3 35
  • 71.54 (n)
  • 75.53 (a)
agpat3 36
  • 75 (a)
OneToOne
Dr.24850 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007113 35
  • 52.46 (n)
  • 41.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4729 35
  • 54.18 (n)
  • 41.24 (a)
CG4729 36
  • 38 (a)
ManyToMany
CG4753 36
  • 36 (a)
ManyToMany
CG4753 37
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 18 (a)
ManyToMany
CST26 36
  • 18 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons LPAT2 35
  • 47.35 (n)
  • 38.41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
Species with no ortholog for AGPAT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGPAT3 Gene

ENSEMBL:
Gene Tree for AGPAT3 (if available)
TreeFam:
Gene Tree for AGPAT3 (if available)

Paralogs for AGPAT3 Gene

Paralogs for AGPAT3 Gene

Selected SIMAP similar genes for AGPAT3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with AGPAT3: view

Variants for AGPAT3 Gene

Sequence variations from dbSNP and Humsavar for AGPAT3 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs7435 -- 43,984,457(+) TAATT(A/G)TTATT utr-variant-3-prime
rs12425 -- 43,985,177(+) TGGGG(A/T)CTCCT utr-variant-3-prime
rs13847 -- 43,982,939(+) CGAAC(A/G)TCAGG utr-variant-3-prime
rs14151 -- 43,986,214(-) CCAGT(C/G)GCGAG utr-variant-3-prime
rs14749 -- 43,986,920(-) GACAA(G/T)CTTCT utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for AGPAT3 Gene

Variant ID Type Subtype PubMed ID
nsv913882 CNV Loss 21882294
nsv834107 CNV Loss 17160897
esv33817 CNV Loss 17666407
nsv834108 CNV Loss 17160897
nsv3538 CNV Loss 18451855
esv29710 CNV Loss 19812545
esv2723623 CNV Deletion 23290073
esv2723624 CNV Deletion 23290073
nsv913887 CNV Loss 21882294
nsv913888 CNV Loss 21882294
esv2723625 CNV Deletion 23290073
nsv913889 CNV Loss 21882294
esv2723626 CNV Deletion 23290073

Relevant External Links for AGPAT3 Gene

HapMap Linkage Disequilibrium report
AGPAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGPAT3 Gene

Disorders for AGPAT3 Gene

Relevant External Links for AGPAT3

Genetic Association Database (GAD)
AGPAT3
Human Genome Epidemiology (HuGE) Navigator
AGPAT3
genes like me logo Genes that share disorders with AGPAT3: view

No data available for UniProtKB/Swiss-Prot for AGPAT3 Gene

Publications for AGPAT3 Gene

  1. The structure and functions of human lysophosphatidic acid acyltransferases. (PMID: 11487472) Leung D.W. (Front. Biosci. 2001) 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for AGPAT3 Gene

Sources for AGPAT3 Gene

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