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Aliases for AGPAT3 Gene

Aliases for AGPAT3 Gene

  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 3 2 3 4 5
  • Lysophosphatidic Acid Acyltransferase Gamma 3 4
  • 1-AGP Acyltransferase 3 3 4
  • EC 2.3.1.51 4 56
  • 1-AGPAT 3 3 4
  • LPAAT3 3 4
  • 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Gamma 3
  • Lysophosphatidic Acid Acyltransferase-Gamma1 3
  • LPAAT-GAMMA1 3
  • LPAAT-Gamma 4

External Ids for AGPAT3 Gene

Previous GeneCards Identifiers for AGPAT3 Gene

  • GC21P041812
  • GC21M041877
  • GC21P044141
  • GC21P044109
  • GC21P045285
  • GC21P030692

Summaries for AGPAT3 Gene

Entrez Gene Summary for AGPAT3 Gene

  • The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGPAT3 Gene

AGPAT3 (1-Acylglycerol-3-Phosphate O-Acyltransferase 3) is a Protein Coding gene. Among its related pathways are COPI-independent Golgi-to-ER retrograde traffic and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT4.

UniProtKB/Swiss-Prot for AGPAT3 Gene

  • Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity).

Gene Wiki entry for AGPAT3 Gene

Additional gene information for AGPAT3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGPAT3 Gene

Genomics for AGPAT3 Gene

GeneHancer (GH) Regulatory Elements for AGPAT3 Gene

Promoters and enhancers for AGPAT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I043863 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.3 1283 5.4 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 YY1 AGPAT3 RNU6-859P UBE2G2 RRP1B HSF2BP WDR4 PWP2 AATBC GC21M043897
GH21I043938 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.3 +74.0 73986 1.6 HDGF PKNOX1 SMAD1 ARNT ARID4B IRF4 ZNF143 DEK MXD4 REST AGPAT3 ICOSLG TRAPPC10 C21orf2 LOC105372826 GC21M043920 RNU6-859P
GH21I044020 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11 +156.2 156193 1.7 PKNOX1 FOXA2 ARID4B TCF12 ATF7 SP3 NCOA1 ZNF592 NFIL3 ZNF184 PWP2 RNU6-859P AGPAT3 TRAPPC10 C21orf2 H2AFZP1
GH21I043933 Enhancer 0.9 dbSUPER 18.8 +70.5 70488 4.1 HDGF HDAC1 GLI4 THRB RARA TCF12 GATA2 EGR1 ZNF207 ATF7 AGPAT3 AATBC LOC105372826 GC21M043920 RNU6-859P
GH21I043974 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.7 +110.3 110319 1 HDGF ATF1 ARNT SIN3A YBX1 GLI4 TCF12 ZNF280A POLR2B CBX5 RRP1B PWP2 U2AF1 TRAPPC10 AATBC SIK1 UBE2G2 RNU6-859P AGPAT3 RRP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AGPAT3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AGPAT3 gene promoter:

Genomic Locations for AGPAT3 Gene

Genomic Locations for AGPAT3 Gene
chr21:43,865,160-43,987,594
(GRCh38/hg38)
Size:
122,435 bases
Orientation:
Plus strand
chr21:45,285,067-45,407,475
(GRCh37/hg19)

Genomic View for AGPAT3 Gene

Genes around AGPAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGPAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGPAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGPAT3 Gene

Proteins for AGPAT3 Gene

  • Protein details for AGPAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRZ7-PLCC_HUMAN
    Recommended name:
    1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
    Protein Accession:
    Q9NRZ7
    Secondary Accessions:
    • D3DSL2
    • Q3ZCU2
    • Q6UWP6
    • Q6ZUC6
    • Q8N3Q7
    • Q9NRZ6

    Protein attributes for AGPAT3 Gene

    Size:
    376 amino acids
    Molecular mass:
    43381 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AGPAT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGPAT3 Gene

Selected DME Specific Peptides for AGPAT3 Gene

Q9NRZ7:
  • WLHKLYQEKDA
  • SQLVMLLEWWS
  • SKVLAKKEL
  • FEIDFLCGW

Post-translational modifications for AGPAT3 Gene

  • Ubiquitination at posLast=119119, Lys201, and Lys236

Domains & Families for AGPAT3 Gene

Gene Families for AGPAT3 Gene

Protein Domains for AGPAT3 Gene

Suggested Antigen Peptide Sequences for AGPAT3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NRZ7

UniProtKB/Swiss-Prot:

PLCC_HUMAN :
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with AGPAT3: view

Function for AGPAT3 Gene

Molecular function for AGPAT3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=4.78 uM for LPA sn-1 C18:1 {ECO:0000269 PubMed:21173190}; KM=21.53 uM for C18:1-CoA {ECO:0000269 PubMed:21173190}; Vmax=6.35 nmol/min/mg enzyme toward LPA sn-1 C18:1 {ECO:0000269 PubMed:21173190}; Vmax=0.74 nmol/min/mg enzyme toward C18:1-CoA {ECO:0000269 PubMed:21173190};
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot Function:
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity).

Enzyme Numbers (IUBMB) for AGPAT3 Gene

Phenotypes From GWAS Catalog for AGPAT3 Gene

Gene Ontology (GO) - Molecular Function for AGPAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0042171 lysophosphatidic acid acyltransferase activity IEA --
genes like me logo Genes that share ontologies with AGPAT3: view
genes like me logo Genes that share phenotypes with AGPAT3: view

Animal Models for AGPAT3 Gene

MGI Knock Outs for AGPAT3:

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AGPAT3 Gene

Localization for AGPAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGPAT3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGPAT3 gene
Compartment Confidence
plasma membrane 5
nucleus 5
endoplasmic reticulum 5
golgi apparatus 5

Gene Ontology (GO) - Cellular Components for AGPAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA --
GO:0005783 endoplasmic reticulum IEA,HDA 16780588
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with AGPAT3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AGPAT3 Gene

Pathways & Interactions for AGPAT3 Gene

genes like me logo Genes that share pathways with AGPAT3: view

UniProtKB/Swiss-Prot Q9NRZ7-PLCC_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.

Gene Ontology (GO) - Biological Process for AGPAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0008152 metabolic process IEA --
GO:0008654 phospholipid biosynthetic process NAS 15367102
GO:0016024 CDP-diacylglycerol biosynthetic process IEA --
genes like me logo Genes that share ontologies with AGPAT3: view

No data available for SIGNOR curated interactions for AGPAT3 Gene

Drugs & Compounds for AGPAT3 Gene

(3) Drugs for AGPAT3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0
Coenzyme A Investigational Nutra 0

(52) Additional Compounds for AGPAT3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with AGPAT3: view

Transcripts for AGPAT3 Gene

Unigene Clusters for AGPAT3 Gene

1-acylglycerol-3-phosphate O-acyltransferase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGPAT3 Gene

No ASD Table

Relevant External Links for AGPAT3 Gene

GeneLoc Exon Structure for
AGPAT3
ECgene alternative splicing isoforms for
AGPAT3

Expression for AGPAT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AGPAT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AGPAT3 Gene

This gene is overexpressed in Nasal epithelium (30.4), Testis (8.6), and Retina (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AGPAT3 Gene



Protein tissue co-expression partners for AGPAT3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AGPAT3 Gene:

AGPAT3

SOURCE GeneReport for Unigene cluster for AGPAT3 Gene:

Hs.248785

mRNA Expression by UniProt/SwissProt for AGPAT3 Gene:

Q9NRZ7-PLCC_HUMAN
Tissue specificity: Widely expressed with highest levels in testis, pancreas and kidney, followed by spleen, lung, adipose tissue and liver.

Evidence on tissue expression from TISSUES for AGPAT3 Gene

  • Nervous system(4.8)
  • Skin(4.4)
  • Kidney(3.3)
  • Eye(3)
genes like me logo Genes that share expression patterns with AGPAT3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGPAT3 Gene

Orthologs for AGPAT3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AGPAT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGPAT3 33 34
  • 98.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AGPAT3 34
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AGPAT3 33 34
  • 88.21 (n)
oppossum
(Monodelphis domestica)
Mammalia AGPAT3 34
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGPAT3 33 34
  • 87.77 (n)
mouse
(Mus musculus)
Mammalia Agpat3 33 16 34
  • 86.08 (n)
rat
(Rattus norvegicus)
Mammalia Agpat3 33
  • 85.64 (n)
chicken
(Gallus gallus)
Aves AGPAT3 33 34
  • 78.19 (n)
lizard
(Anolis carolinensis)
Reptilia AGPAT3 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agpat3 33
  • 75.2 (n)
Str.11652 33
African clawed frog
(Xenopus laevis)
Amphibia agpat3-prov 33
zebrafish
(Danio rerio)
Actinopterygii agpat3 33 34
  • 71.54 (n)
Dr.24850 33
fruit fly
(Drosophila melanogaster)
Insecta CG4729 33 34
  • 54.18 (n)
CG4753 35 34
  • 37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007113 33
  • 52.46 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 18 (a)
ManyToMany
CST26 34
  • 18 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons LPAT2 33
  • 47.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
Species where no ortholog for AGPAT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGPAT3 Gene

ENSEMBL:
Gene Tree for AGPAT3 (if available)
TreeFam:
Gene Tree for AGPAT3 (if available)

Paralogs for AGPAT3 Gene

Paralogs for AGPAT3 Gene

(2) SIMAP similar genes for AGPAT3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with AGPAT3: view

Variants for AGPAT3 Gene

Sequence variations from dbSNP and Humsavar for AGPAT3 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000029972 -- 43,940,598(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000043612 -- 43,870,248(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000071521 -- 43,976,496(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000080198 -- 43,940,860(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000080223 -- 43,903,898(+) C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AGPAT3 Gene

Variant ID Type Subtype PubMed ID
dgv2504e59 CNV duplication 20981092
esv2723623 CNV deletion 23290073
esv2723624 CNV deletion 23290073
esv2723625 CNV deletion 23290073
esv2723626 CNV deletion 23290073
esv29710 CNV loss 19812545
esv33817 CNV loss 17666407
esv3397810 CNV duplication 20981092
esv3647117 CNV loss 21293372
nsv1055772 CNV loss 25217958
nsv1063752 CNV gain 25217958
nsv1073136 CNV deletion 25765185
nsv1116930 CNV deletion 24896259
nsv1122045 CNV deletion 24896259
nsv1126612 CNV deletion 24896259
nsv1127900 CNV deletion 24896259
nsv1151323 CNV duplication 26484159
nsv3538 CNV deletion 18451855
nsv472902 CNV novel sequence insertion 20440878
nsv834107 CNV loss 17160897
nsv834108 CNV loss 17160897
nsv953643 CNV deletion 24416366

Variation tolerance for AGPAT3 Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AGPAT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGPAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGPAT3 Gene

Disorders for AGPAT3 Gene

Additional Disease Information for AGPAT3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for AGPAT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGPAT3 Gene

Publications for AGPAT3 Gene

  1. Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. (PMID: 21829377) Lemaitre RN … Steffen LM (PLoS genetics 2011) 3 44 58
  2. Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria. (PMID: 21173190) Prasad SS … Agarwal AK (Journal of lipid research 2011) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Membrane topology of human AGPAT3 (LPAAT3). (PMID: 20537980) Schmidt JA … Brown WJ (Biochemical and biophysical research communications 2010) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for AGPAT3 Gene

Sources for AGPAT3 Gene

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